Traditional Chinese medicine composition for treating metabolic syndrome complicated with atherosclerosis

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, which is characterized in that the traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 2-6 parts of raw rhubarb, 8-18 parts of coptis chinensis, 8-18 parts of rhizoma pinelliae preparata, 8-18 parts of trichosanthes kirilowii maxim, 2-6 parts of prepared leech, 8-18 parts of salvia miltiorrhiza and 8-18 parts of curcuma zedoary. According to the traditional Chinese medicine composition provided by the invention, under the guidance of a state target theory, through the compatibility of seven traditional Chinese medicines including raw rhubarb, coptis chinensis, rhizoma pinelliae preparata, trichosanthes kirilowii maxim, prepared leech, salvia miltiorrhiza and curcuma zedoary, MetS and AS can be prevented and treated; meanwhile, tests show that the traditional Chinese medicine composition can improve general conditions of high-glucose, high-fat and high-cholesterol diet induced ApoE <- / -> mice, reduce weight and blood pressure of the mice, improve lipid metabolism disorder of the mice and reduce AS plaque area; and the pharmaceutical composition also has the advantages of anti-atherosclerosis effect and good safety.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and more particularly to a traditional Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis. Background Art

[0002] Metabolic syndrome (MetS) is a pathological state that occurs under the combined effects of genetic, immune and environmental factors, with insulin resistance as the basis of disease onset, obesity (especially central obesity) as the initiating factor, and metabolic disorders of substances such as proteins, fats and carbohydrates. The multiple metabolic disorders of MetS are closely related to vascular lesions. Studies have shown that the risk factors of each link interact with each other, jointly leading to vascular endothelial damage and destruction of vascular homeostasis, and then participating in target organ damage. For example, excessive fat accumulation can induce oxidative stress, insulin resistance and inflammation, and damage vascular endothelial function; high uric acid causes vascular endothelial damage through various pathways such as oxidative stress, inflammatory response and smooth muscle proliferation; the expression of inflammatory genes increases under hyperglycemia, accelerates the generation of advanced glycation end products, directly induces endothelial cell apoptosis, damages vascular endothelial structure, and increases vascular permeability. In addition, metabolic disorders can also reduce plaque stability, and insulin levels are associated with vulnerable components of carotid plaques, especially intraplaque hemorrhage.

[0003] Metabolic cardiovascular disease refers to a clinical syndrome in which there is a causal relationship between metabolic abnormalities and cardiovascular damage, excluding other cardiovascular causes, with atherosclerotic cardiovascular disease as the main pathophysiological change, cardiovascular and cerebrovascular events as the main outcome, and intervention in metabolic disorders helps improve prognosis. It is mainly manifested as atherosclerotic cardiovascular disease, such as coronary heart disease, sudden cardiac death and heart failure, and intervention in metabolic disorders can improve prognosis.

[0004] Atherosclerosis (AS) is a systemic disease, especially common in the elderly. Its characteristic is that the lesions of the affected arteries start from the intima, generally with the accumulation of lipids and complex carbohydrates, bleeding and thrombosis, followed by fibrosis and calcification, and the gradual degeneration and calcification of the middle layer of the artery, leading to thickening and hardening of the arterial wall and narrowing of the blood vessel lumen. The lesions often involve large and medium arteries. Once they develop to the point where the arterial lumen is blocked, the tissues or organs supplied by the artery will be ischemic or necrotic. AS accounts for a large proportion of cardiovascular diseases. Studies have shown that cardiovascular and cerebrovascular events caused by AS have become an important killer that seriously threatens human health.

[0005] At present, Western medicine has made great progress in the study of atherosclerosis. The treatment of atherosclerosis is mainly through lowering blood lipids, anti-platelet aggregation, etc., but the long-term efficacy is still not ideal, and conventional Western medicines for the treatment of atherosclerosis have certain toxic and side effects. Traditional Chinese medicine has natural advantages in multi-target intervention, improving metabolic and inflammatory states, and personalized treatment, providing valuable treatment options for the comprehensive management of MetS combined with AS. The development process of MetS from obesity to multiple metabolic disorders to final cardiovascular and cerebrovascular complications is basically consistent with "spleen deficiency". Therefore, modern Chinese medicine proposes that MetS can be classified as a spleen deficiency, and proposes a "state target" treatment theory to construct a metabolic syndrome state target treatment system characterized by classification and staging. Based on this theory, the present invention studies a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis to solve the above-mentioned problems. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis under the guidance of the "state-target" theory.

[0007] In order to achieve the above-mentioned object, the present invention provides a traditional Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, wherein the traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 2 to 6 parts of raw rhubarb, 8 to 18 parts of coptis chinensis, 8 to 18 parts of pinellia ternata, 8 to 18 parts of trichosanthes, 2 to 6 parts of processed leech, 8 to 18 parts of salvia miltiorrhiza, and 8 to 18 parts of zedoaria.

[0008] Preferably, the Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 3-4 parts of raw rhubarb, 12-15 parts of coptis chinensis, 12-15 parts of pinellia ternata, 12-15 parts of trichosanthes, 3-4 parts of processed leech, 12-15 parts of salvia miltiorrhiza, and 12-15 parts of curcuma.

[0009] Preferably, the Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 3 parts of raw rhubarb, 15 parts of coptis chinensis, 15 parts of pinellia ternata, 15 parts of trichosanthes, 3 parts of processed leech, 15 parts of salvia miltiorrhiza, and 15 parts of curcuma.

[0010] Preferably, the extraction and preparation method is: weigh raw rhubarb, coptis chinensis, pinellia ternata, trichosanthes kirilowii, processed leech, salvia miltiorrhiza and curcuma, a total of 7 raw medicinal materials by weight, add 8 to 12 times the total weight of the raw medicinal materials of water and decoct twice, filter, combine the filtrates of the two decoctions, concentrate the filtrate, and add auxiliary materials to prepare a pharmaceutical preparation.

[0011] Preferably, the decoction is performed by soaking for 0.5 to 1 hour before the first decoction, and the second decoction time is 1 to 2 hours.

[0012] Preferably, the decoction is specifically to add 12 times the amount of water for the first time and decoct for 2 hours, soak for 1 hour before decoction, and add 8 times the amount of water for the second time and decoct for 1 hour.

[0013] It should be noted that the above-mentioned extraction and preparation method can also be at least one of immersion method, percolation method, modified gelatin method, reflux method, solvent extraction method, steam distillation method, sublimation method, supercritical fluid extraction method, membrane separation technology, ultrafine grinding technology, traditional Chinese medicine flocculation separation technology, semi-bionic extraction method, ultrasonic extraction method, cyclone extraction method, pressurized countercurrent extraction method, enzyme method, macroporous resin adsorption method, ultrafiltration method and molecular distillation method.

[0014] Preferably, the excipient is a medically acceptable excipient.

[0015] Preferably, the pharmaceutical preparation is one of a decoction, a pill, a granule, a capsule, a tablet, a powder, an ointment, an oral liquid, or a powder.

[0016] The present invention also provides an application of the above-mentioned traditional Chinese medicine composition in preparing a medicine for treating metabolic syndrome combined with atherosclerosis.

[0017] It should be noted that the pharmacological effects of the raw medicinal materials in the Chinese medicine composition of the present invention are as follows:

[0018] Raw rhubarb: The dried roots and rhizomes of Rheum palmatum L., Rheum tanguticum Maxim. ex Balf. or medicinal rhubarb Rheum officinale Baill. of the Polygonaceae family. Raw rhubarb, also known as raw rhubarb, is made by removing impurities from the original medicine, sorting by size, stewing until the internal and external moisture is uniform, slicing or cutting into small pieces, and drying in the sun. Nature and flavor and meridians: bitter, cold. It enters the spleen, stomach, large intestine, liver, and pericardium meridians. Functions and indications: purging and attacking accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredges the menstruation, and removing dampness and jaundice. It is used for constipation caused by excess heat accumulation, vomiting and bleeding caused by blood heat, red eyes and swollen throat, carbuncle, abdominal pain caused by intestinal carbuncle, amenorrhea caused by blood stasis, postpartum blood stasis, traumatic injury, damp-heat dysentery, jaundice and red urine, stranguria, edema; external treatment for burns and scalds.

[0019] Coptis chinensis: the dried rhizome of Coptis chinensis Franch., Coptis deltoidea C.Y. Chenget Hsiao or Coptis teeta Wall. of the Ranunculaceae family. Nature and flavor and meridians: bitter, cold. It enters the heart, spleen, stomach, liver, gallbladder and large intestine meridians. Functions and indications: clearing away heat and dampness, purging fire and detoxifying. It is used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, palpitations, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle, furuncle; external treatment of eczema, wet sores and pus in the ear canal.

[0020] Qing Banxia: a processed product of Banxia (the dried tuber of Pinellia ternata (Thunb.) Breit., a plant of the Araceae family). Nature and flavor and meridians: pungent, warm. It enters the spleen, stomach, and lung meridians. Functions and indications: drying dampness and resolving phlegm. It is used for cough with damp phlegm, fullness in the stomach, condensed phlegm, and inability to cough it out.

[0021] Trichosanthes kirilowii Maxim. or Trichosanthes rosthornii Harms, a plant of the Cucurbitaceae family, is a dried and mature fruit. Nature and flavor and meridians: sweet, slightly bitter, cold. It enters the lung, stomach, and large intestine meridians. Functions and indications: clearing away heat and removing phlegm, relieving chest congestion and dispersing stagnation, moistening dryness and lubricating intestines. It is used for cough due to lung heat, turbid yellow and thick phlegm, chest obstruction and heart pain, chest congestion and fullness, breast abscess, lung abscess, intestinal abscess, and constipation.

[0022] Processed leech: the dried whole body of Whitmaniapigra Whitman, Hirudo nipponicaWhitman or Whitmania acranulata Whitman, which are animals of the Hirudinidae family. Processed leech is also scalded leech. Take clean leech segments and scald them with talcum powder until they swell slightly according to the stir-frying method (General Rule 0213). Nature and flavor and meridians: salty, bitter, flat; slightly toxic. It enters the liver meridian. Functions and indications: It can break blood and promote menstruation, remove blood stasis and eliminate symptoms. It is used for blood stasis, amenorrhea, lumps and masses, hemiplegia caused by stroke, and injuries caused by falls.

[0023] Danshen: The dried root and rhizome of Salvia miltiorrhiza Bge., a plant of the Labiatae family. Nature and flavor and meridians: bitter, slightly cold. It enters the heart and liver meridians. Functions and indications: It can activate blood circulation and remove blood stasis, relieve pain by promoting menstruation, clear the heart and relieve restlessness, cool blood and eliminate carbuncle. It is used for chest pain, pain in the abdomen and flanks, accumulation of masses, pain due to heat arthralgia, restlessness and insomnia, irregular menstruation, dysmenorrhea and amenorrhea, and swelling and pain in sores.

[0024] Curcuma: The dried rhizome of Curcumaphaeocaulis Val., Curcuma wangsiensis SGLee et CFLiang or Curcuma wenyujin YHChenetC.Ling. Nature and flavor: pungent, bitter, warm. Enters the liver and spleen meridians. Functions and indications: promotes qi and resolves blood, eliminates stagnation and relieves pain. Used for lumps and masses, blood stasis and amenorrhea, chest pain and heartache, and bloating and pain caused by food stagnation.

[0025] Modern pharmacology studies have found that raw rhubarb has anti-tumor, anti-inflammatory, diarrhea, oxygen free radical scavenging, lipid-lowering, immune regulation and other effects; Coptidis has antiarrhythmic, hypoglycemic, anti-inflammatory, anti-tumor, antibacterial and other effects; Pinellia ternata has antitussive, expectorant, antiemetic, anti-tumor, antibacterial and other effects; Fructus Trichosanthis has expectorant, antibacterial, hypotensive, diarrhea, coronary artery dilatation, improves myocardial blood supply and other effects; Processed leech has anticoagulant, antithrombotic, anti-tumor, anti-atherosclerosis, anti-fibrosis and other effects; Salvia miltiorrhiza has increased coronary flow, anti-oxidation, cardiovascular protection, improves renal function, anti-bacterial anti-inflammatory, anti-tumor and other effects; Curcuma has antitumor, anti-platelet aggregation, anti-thrombotic, blood lipid regulating, anti-atherosclerosis and other effects. Therefore, the present invention selects Chinese medicine raw rhubarb, Coptidis, Pinellia ternata, Fructus Trichosanthis, Processed leech, Salvia miltiorrhiza, Curcuma as active ingredients.

[0026] The present invention has the following beneficial effects:

[0027] 1. In the Chinese medicine prescription of the present invention, raw rhubarb has the functions of purging and attacking accumulation, clearing away heat and purging fire, while coptis root clears heat and dries dampness, clears away fire and detoxifies. Raw rhubarb and coptis root are used together as the main medicine; pinellia tuber is used to dry dampness and resolve phlegm, descends adverse and stops vomiting, and trichosanthes root clears heat and resolves phlegm, relieves chest tightness and resolves stagnation. Pinellia tuber and trichosanthes root are used together as the ministerial medicine. Processed leech can break blood and dredge menstruation, remove blood stasis and eliminate symptoms, salvia root can promote blood circulation and remove blood stasis, cool blood and eliminate carbuncle, and zedoaria root can break blood and promote qi circulation, eliminate accumulation and relieve pain. Processed leech, salvia root and zedoaria root are used together as adjuvant medicine. All the medicines are used together to play the effects of purging heat and removing blood stasis, resolving phlegm and resolving stagnation.

[0028] 2. The Chinese medicine composition of the present invention, under the guidance of the "state target" theory, can prevent and treat MetS combined with AS through the compatibility of seven Chinese medicines: raw rhubarb, coptis root, pinellia tuber, trichosanthes, processed leech, salvia miltiorrhiza and zedoaria. At the same time, experiments show that ApoE- / - mice induced by a high-sugar, high-fat, and high-cholesterol diet can significantly reduce serum cholesterol levels and plaque area after being treated with the Chinese medicine composition of the present invention for 12 weeks. In other words, the Chinese medicine composition provided by the present invention has an anti-atherosclerotic effect, and it also has the advantage of good safety and is suitable for long-term use. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is the HE and Oil Red O staining result of the aortic sinus in the present invention;

[0030] Figure 2 This is the Oil Red O staining result of the aorta in the present invention. DETAILED DESCRIPTION

[0031] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0032] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0033] Embodiment 1:

[0034] A preparation method for a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis comprises the following steps: weighing 3g of raw rhubarb, 15g of coptis root, 15g of pinellia tuber, 15g of trichosanthes root, 3g of processed leech, 15g of salvia miltiorrhiza and 15g of zedoaria by weight, adding 12 times the total weight of raw medicinal materials of water, soaking for 1 hour, then decocting for 2 hours, filtering; then adding 8 times the amount of water, decocting for 1 hour, filtering; combining the filtrates of the two decoctions, decompressing and concentrating the filtrates into dry extract, and crushing.

[0035] Embodiment 2:

[0036] The invention discloses a preparation method of a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, comprising the following steps: weighing 2g of raw rhubarb, 18g of coptis root, 8g of pinellia tuber, 8g of trichosanthes root, 6g of processed leech, 18g of salvia miltiorrhiza and 18g of zedoaria by weight, adding water in an amount 10 times the total weight of the raw medicinal materials, soaking for 0.5h, then decocting for 1.5h, filtering; adding 10 times the amount of water, decocting for 1.5h, filtering; combining the filtrates of the two decoctions, decompressing and concentrating the filtrates into dry extract, crushing and preparing powder.

[0037] Embodiment three:

[0038] The invention discloses a preparation method of a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, comprising the following steps: weighing 6g of raw rhubarb, 8g of coptis root, 18g of pinellia tuber, 18g of trichosanthes root, 2g of processed leech, 8g of salvia miltiorrhiza and 8g of zedoaria by weight, adding water in an amount 8 times the total weight of the raw medicinal materials, soaking for 1 hour, then decocting for 1.5 hours, filtering; then adding 10 times the amount of water, decocting for 1 hour, filtering; combining the filtrates of the two decoctions, decompressing and concentrating the filtrates into dry extract, crushing and preparing powder.

[0039] Embodiment 4:

[0040] The invention discloses a preparation method of a Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, comprising the following steps: weighing 4g of raw rhubarb, 12g of coptis root, 12g of pinellia tuber, 12g of trichosanthes root, 4g of processed leech, 12g of salvia miltiorrhiza and 12g of zedoaria by weight, adding water in an amount 8 times the total weight of the raw medicinal materials, soaking for 1 hour, then decocting for 1.5 hours, filtering; then adding 10 times the amount of water, decocting for 1 hour, filtering; combining the filtrates of the two decoctions, decompressing and concentrating the filtrates into dry extract, crushing and preparing powder.

[0041] Test example:

[0042] 1. Experimental Methods

[0043] 1. Experimental animals, grouping and model preparation

[0044] 20 male 8-week-old ApoE- / - mice and 10 male 8-week-old C57BL / 6 mice. C57BL / 6 mice were used as a blank control group. ApoE- / - mice were randomly divided into a model group and a Chinese medicine composition group (powder prepared in Example 1), with 10 mice in each group. After 1 week of adaptive feeding, the blank control group was fed with ordinary maintenance feed for 12 weeks, and the remaining groups were fed with high-sugar, high-fat, high-cholesterol feed (TP26304) for 12 weeks.

[0045] 2. Experimental groups and drug administration

[0046] The Chinese medicine composition group (powder prepared in Example 1) was given an intragastric administration of a clinical equivalent dose, while the blank control group and the model group were given an intragastric administration of corresponding sterile drinking water, and both were given preventive medication for 12 weeks.

[0047] The blank control group was group A: normal feed, and an equal volume of sterile drinking water was gavaged once a day.

[0048] The model group was group B: the mice were fed with a high-sugar, high-fat, and high-cholesterol diet and intragastrically administered with an equal volume of sterile drinking water once a day.

[0049] The Chinese medicine combination group was Group C: high-sugar, high-fat, high-cholesterol feed, 2.13 g / kg / d (calculated based on the amount of original medicinal materials contained) was gavaged once a day.

[0050] 3. Data and sample collection

[0051] After 12 weeks of administration, the mice were tested for body weight and non-invasive blood pressure. Before sampling, all mice were fasted but not watered for 4-8 hours, and the mice were anesthetized using isoflurane aerosol anesthesia. After complete anesthesia, the eyeballs were removed to collect blood, about 1 mL / mouse, and placed in a low-temperature high-speed centrifuge at room temperature for 30 minutes, centrifuged at 4°C for 15 minutes at a centrifugal speed of 3000 rpm per minute, and the supernatant was divided (100uL / tube, operated on ice), and frozen in a -80°C refrigerator for subsequent lipid four tests. After blood collection, PBS was used for cardiac perfusion quickly: the skin and ribs of the chest cavity were cut open to expose the heart; the injection needle was inserted into the left ventricle of the mouse, fixed with hemostatic forceps, and the right auricle was cut to allow blood to flow out, and the perfusion rate was 1mL / min. After perfusion, the heart and aorta were taken out in turn, fixed in 4% paraformaldehyde fixative for 48 hours, and then the aortic sinus HE and Oil Red O staining were performed.

[0052] 2. Experimental Results

[0053] 2.1 Effects on body weight, blood pressure and blood lipids

[0054] Table 1 shows the results of the body weight and blood pressure measurements of mice. As can be seen from the data in Table 1, compared with the control group, the body weight and blood pressure of the model group were significantly increased. The Chinese medicine composition group significantly reduced the body weight and blood pressure levels. This shows that the Chinese medicine composition provided by the present invention can significantly improve the body weight and blood pressure of MetS combined with AS mice.

[0055] Table 1 Comparison of body weight and blood pressure test results of each group (mmol / L, )

[0056]

[0057] Note: Compared with the normal group, *P<0.05, **P<0.01; compared with the model group, #P<0.05, ##P<0.01.

[0058] Table 2 shows the results of blood lipid measurement in mice. As can be seen from the results in Table 1, compared with the control group, the serum total cholesterol (TC), triglycerides (TG) and protein cholesterol (LDL) in the model group were significantly increased. The Chinese medicine composition group significantly reduced serum TC, TG and LDL levels. This shows that the Chinese medicine composition provided by the present invention can significantly improve the cholesterol metabolism disorder in MetS combined with AS mice. The MetS model was successful, and after 12 weeks of preventive treatment with the Chinese medicine composition prepared by the present invention, body weight, blood pressure and blood lipids were improved.

[0059] Table 2 Comparison of serum lipid levels in each group (mmol / L, )

[0060]

[0061] Note: Compared with the normal group, *P<0.05, **P<0.01; compared with the model group, #P<0.05, ##P<0.01.

[0062] 2.2 Effect on aortic plaque area

[0063] Figure 1 The results of HE and Oil Red O staining of mouse aortic sinus. Figure 2 Table 3 is the statistical table of the plaque area of ​​HE and Oil Red O staining of the mouse aorta. Figure 1 , Figure 2 As shown in the results of Table 3, compared with C57BL / 6J mice, ApoE- / - mice fed with a high-fat diet for 12 weeks had obvious aortic plaques and a successful AS model. After 12 weeks of preventive treatment with the Chinese medicine composition prepared by the present invention, the aortic plaque area of ​​mice in the Chinese medicine composition group was significantly reduced compared with that in the model group.

[0064] Table 3 shows the statistical data of the plaque area of ​​the mouse aortic sinus stained with HE and Oil Red O

[0065]

[0066] Note: Compared with the normal group, *P<0.05, **P<0.01; compared with the model group, #P<0.05, ##P<0.01.

[0067] In summary, the Chinese medicine composition of the present invention can improve the general condition of ApoE- / - mice induced by a high-sugar, high-fat, and high-cholesterol diet, reduce the weight and blood pressure of mice, improve lipid metabolism disorders in mice, and reduce the area of ​​AS plaques, thereby playing an effective role in intervening in the treatment of MetS combined with AS.

[0068] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating metabolic syndrome combined with atherosclerosis, characterized in that: The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 2-6 parts of raw rhubarb, 8-18 parts of coptis chinensis, 8-18 parts of pinellia ternata, 8-18 parts of trichosanthes, 2-6 parts of processed leech, 8-18 parts of salvia miltiorrhiza, and 8-18 parts of zedoaria.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 3-4 parts of raw rhubarb, 12-15 parts of coptis chinensis, 12-15 parts of pinellia ternata, 12-15 parts of trichosanthes, 3-4 parts of processed leech, 12-15 parts of salvia miltiorrhiza, and 12-15 parts of zedoaria.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 3 parts of raw rhubarb, 15 parts of coptis chinensis, 15 parts of pinellia ternata, 15 parts of trichosanthes, 3 parts of processed leech, 15 parts of salvia miltiorrhiza, and 15 parts of zedoaria.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The extraction and preparation method comprises the following steps: weighing raw rhubarb, coptis root, pinellia tuber, trichosanthes root, processed leech, salvia miltiorrhiza and zedoaria, a total of 7 raw medicinal materials by weight, adding water in an amount of 8 to 12 times the total weight of the raw medicinal materials, decocting twice, filtering, combining the filtrates of the two decoctions, concentrating the filtrates, and adding auxiliary materials to prepare a pharmaceutical preparation.

5. The Chinese medicine composition according to claim 4, characterized in that: The decoction is performed by soaking for 0.5 to 1 hour before the first decoction, and the second decoction takes 1 to 2 hours.

6. The Chinese medicine composition according to claim 4, characterized in that: The decoction is specifically as follows: adding 12 times the amount of water for the first time and decoct for 2 hours, soaking for 1 hour before decoction, and adding 8 times the amount of water for the second time and decoct for 1 hour.

7. The Chinese medicine composition according to claim 4, characterized in that: The auxiliary materials are medically acceptable auxiliary materials.

8. The Chinese medicine composition according to claim 4, characterized in that: The pharmaceutical preparation is one of decoction, pill, granule, capsule, tablet, powder, paste, oral liquid, or powder.

9. Use of the Chinese medicine composition according to any one of claims 5 to 8 in the preparation of a medicament for treating metabolic syndrome combined with atherosclerosis.

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