Traditional Chinese medicine composition and granule for preventing or treating plateau gastrointestinal stress syndrome and preparation method of traditional Chinese medicine composition and granule

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and granules for preventing or treating plateau gastrointestinal stress syndrome and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of ginger processed pinellia, 6-15 parts of scutellaria baicalensis, 10-15 parts of poria cocos, 10-15 parts of roasted rhizoma atractylodis macrocephalae, 6-15 parts of red ginseng, 3-6 parts of coptis chinensis, 3-6 parts of honey-fried licorice root, 3-6 parts of safflower carthamus, 6-9 parts of dried ginger, 3-6 parts of Chinese dates, 6-15 parts of radix ophiopogonis, 3-6 parts of fresh ginger and 10-15 parts of red halloysite. According to the technical scheme, the raw materials of the original traditional Chinese medicine composition are improved, the fermentation culture solution is used for fermentation treatment in the preparation process, and the probiotics are added, so that the problems that the absorption rate of the original traditional Chinese medicine composition for gastrointestinal stress patients is not high, the required dosage is large, and the burden of intestines and stomach is also increased due to the excessive dosage are solved.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and granules for preventing or treating high altitude gastrointestinal stress syndrome and a preparation method thereof. Background Art

[0002] The incidence of plateau gastrointestinal stress is higher in altitude sickness, which is often manifested by symptoms such as abdominal distension, abdominal pain, decreased appetite, nausea, acid reflux, heartburn, vomiting, diarrhea, constipation, bloody or black stools, pharyngitis, etc. The main pathological changes in electronic gastroenteroscopy are gastrointestinal mucosal congestion, edema, erosion, congestion, bile reflux and even ulcers. The final result is a plateau pathological change characterized by inflammatory erosion, exudation, bleeding and ulcers of gastrointestinal mucosal tissue.

[0003] Long-term exposure to high-altitude gastrointestinal stress and damaged gastrointestinal mucosal barrier can affect the body's nutrient intake and promote the release of intestinal toxins into the blood, or cause the occurrence of plateau-related metabolic syndrome, such as hyperuricemia, nutritional mineral deficiency, impaired liver cell function, hyperbilirubinemia, etc. In more serious cases, it can cause systemic multiple organ dysfunction. The principle is that the characteristics of plateau such as hypoxia, dryness and coldness can lead to changes in the transmission of the local sympathetic nervous system and vagus nervous system of the gastrointestinal mucosa, resulting in the release of neurotransmitters and inflammatory cytokines, causing vasoconstriction and leading to gastrointestinal mucosal ischemia and hypoxia, increased microvascular permeability, and obstructed blood rheology, stasis and damaged mucosal barrier; in addition, the body's secondary polycythemia in the hypoxic environment of high altitude areas causes increased blood viscosity in blood vessels, which can make the microcirculation of gastrointestinal mucosal tissue unable to effectively exchange nutrients and gases, thereby leading to increased anaerobic metabolism and a large accumulation of hydrogen ions and harmful substances, causing the weakening of mucosal microcirculation and mucosal barrier function and further aggravated damage to the gastrointestinal mucosa, ultimately leading to the body's gastrointestinal mucosa losing its ability to resist various damaging factors, causing the occurrence of acute and chronic gastrointestinal mucosal injury lesions in the plateau.

[0004] CN110638984B discloses a Chinese medicine composition, granules and preparation method thereof for preventing or treating high altitude gastrointestinal stress syndrome, wherein the Chinese medicine composition is composed of 10-15 parts by weight of ginger pinellia, 6-15 parts by weight of scutellaria, 10-15 parts by weight of tuckahoe, 10-15 parts by weight of stir-fried atractylodes, 6-15 parts by weight of red ginseng, 3-6 parts by weight of coptis root, 3-6 parts by weight of roasted licorice root, 3-6 parts by weight of safflower, 6-9 parts by weight of dried ginger, 3-6 parts by weight of jujube, and 6-15 parts by weight of ophiopogon, and can achieve good therapeutic effects of improving high altitude gastrointestinal stress symptoms, such as nausea, pantothenic acid, belching, diarrhea, etc. However, after testing, the Chinese medicine composition has the problem of low absorption rate for patients with gastrointestinal stress, and a large dosage is required to achieve the therapeutic effect, and too large a dosage will also increase the burden on the stomach. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition, granules and preparation method thereof for preventing or treating high altitude gastrointestinal stress syndrome, which is improved on the basis of the Chinese medicine composition of the background technology to solve the problems existing in the background technology.

[0006] To achieve the above objectives, this application is implemented through the following technical solutions:

[0007] A Chinese medicine composition for preventing or treating high altitude gastrointestinal stress syndrome, the Chinese medicine composition is made from the following raw materials:

[0008] 10-15 weight parts of Pinellia ternata, 6-15 weight parts of Scutellaria baicalensis, 10-15 weight parts of Poria cocos, 10-15 weight parts of stir-fried Atractylodes macrocephala, 6-15 weight parts of red ginseng, 3-6 weight parts of Coptis chinensis, 3-6 weight parts of roasted Licorice root, 3-6 weight parts of Carthamus tinctorius, 6-9 weight parts of dried ginger, 3-6 weight parts of jujube, 6-15 weight parts of Ophiopogon japonicus, 3-6 weight parts of ginger, and 10-15 weight parts of red ochre.

[0009] Furthermore, the Chinese medicine composition is made from the following raw materials:

[0010] 12 parts by weight of Pinellia ternata, 10 parts by weight of Scutellaria baicalensis, 10 parts by weight of Poria cocos, 10 parts by weight of stir-fried Atractylodes macrocephala, 10 parts by weight of red ginseng, 3 parts by weight of Coptis chinensis, 5 parts by weight of roasted Licorice root, 6 parts by weight of Safflower, 6 parts by weight of dried ginger, 4 parts by weight of jujube, 10 parts by weight of Ophiopogon japonicus, 5 parts by weight of ginger, and 12 parts by weight of red ochre.

[0011] A Chinese medicine composition granule for preventing or treating high altitude gastrointestinal stress syndrome comprises any one of the above Chinese medicine compositions and probiotics.

[0012] Furthermore, the probiotics are Lactobacillus gasseri LG-084 and / or Lactobacillus ttyS-839.

[0013] Furthermore, the weight ratio of the Chinese medicine composition to the probiotics is 8-9:1.

[0014] Furthermore, it also includes inulin, and the weight ratio of inulin to probiotics is 1:1.

[0015] Furthermore, the number of viable probiotic bacteria per 10 g of the Chinese medicine composition granules is greater than 10 9 .

[0016] A method for preparing any of the above-mentioned Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome comprises the following steps:

[0017] S1. Crush the raw materials of the above-mentioned Chinese medicine composition, decoct twice, filter, discard the residue, and combine the decoctions of the two decoctions;

[0018] S2, cooling the soup to 35-39°C, adjusting the pH value to 7±0.5, and inoculating the fermentation culture medium;

[0019] S3, the fermentation time is 72-96 hours, and after the fermentation is completed, the Chinese medicine composition is obtained by inactivation, drying and crushing;

[0020] S4. Add probiotics to the Chinese medicine composition and mix well to obtain granules of the Chinese medicine composition.

[0021] Furthermore, the bacterial species in the fermentation culture medium in step S2 are bifidobacteria and lactobacilli.

[0022] Furthermore, the bacterial species number ratio of bifidobacterium and lactobacillus is 2:1-1:1.

[0023] The beneficial effects of the present invention are:

[0024] The technical solution improves the raw materials of the original Chinese medicine composition, and uses fermentation culture medium for fermentation treatment and adds probiotics during the preparation process, thereby solving the problem that the original Chinese medicine composition has a low absorption rate for patients with gastrointestinal stress, requires a large dosage, and excessive dosage will also increase the burden on the stomach and intestines. DETAILED DESCRIPTION

[0025] The technical solution of the present invention is described in detail below through examples. The following examples are merely exemplary and can only be used to explain and illustrate the technical solution of the present invention, but cannot be construed as limiting the technical solution of the present invention.

[0026] For the effects of the various raw materials of the Chinese medicine composition involved in this application, please refer to the contents disclosed in CN110638984B.

[0027] In the technical scheme of the present application, although the dried ginger component is used to warm the stomach, the effect of dried ginger on warming the lungs is higher than that on warming the stomach, because the effect of dried ginger is internal cold, and dried ginger is mainly used for internal cold of the internal organs. Therefore, Sini Decoction uses dried ginger but not fresh ginger. In "Shennong's Herbal Classic", the effect of fresh ginger is to warm the stomach. Therefore, dried ginger is not used in the traditional Chinese medicine components for warming the stomach. In the present technical scheme, taking into account the acute and chronic gastrointestinal mucosal damage caused by altitude sickness, it belongs to the injury of the spleen and stomach. According to the theory of traditional Chinese medicine, the mother's disease should be supplemented by its son, and the lung is the son of the spleen. Therefore, in the present technical scheme, dried ginger and fresh ginger are used at the same time.

[0028] In this technical solution, the Chinese medicinal material red ochre is added at the same time, which is borrowed from Peach Blossom Soup. In this technical solution, red ochre is not used raw, and it works together with Poria cocos and stir-fried Atractylodes macrocephala to nourish the spleen and stomach.

[0029] Example 1

[0030] A Chinese medicine composition granule for preventing or treating high altitude gastrointestinal stress syndrome, wherein the Chinese medicine composition is made of the following raw materials:

[0031] 10 parts by weight of Pinellia ternata, 6 parts by weight of Scutellaria baicalensis, 10 parts by weight of Poria cocos, 10 parts by weight of stir-fried Atractylodes macrocephala, 6 parts by weight of red ginseng, 3 parts by weight of Coptis chinensis, 3 parts by weight of roasted Licorice root, 3 parts by weight of Safflower, 6 parts by weight of dried ginger, 3 parts by weight of jujube, 6 parts by weight of Ophiopogon japonicus, 3 parts by weight of ginger, and 10 parts by weight of red ochre.

[0032] The method for preparing the above-mentioned Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome adopts the following steps:

[0033] S1. Crush the raw materials of the above-mentioned Chinese medicine composition, decoct them twice, filter them, discard the residues, and combine the decoctions from the two decoctions.

[0034] S2. Cool the soup to 35-39°C, adjust the pH to 7±0.5, and the humidity to 60%±5%. Inoculate the fermentation culture medium with a ratio of 1:1 between Bifidobacterium and Lactobacillus.

[0035] S3. The fermentation time is 72 hours. After the fermentation is completed, the Chinese medicine composition is obtained by inactivation, freeze-drying and pulverization.

[0036] S4. Add probiotics to the Chinese medicine composition and mix well to obtain granules of the Chinese medicine composition.

[0037] Specifically, the above-mentioned Chinese medicine composition granules are packaged in 10g bags, which are composed of 8g of the Chinese medicine composition, 1g of Lactobacillus gasseri LG-084 and 1g of inulin, and the number of viable probiotic bacteria in each bag of the Chinese medicine composition granules is greater than 10 9 .

[0038] Example 2

[0039] A Chinese medicine composition granule for preventing or treating high altitude gastrointestinal stress syndrome, wherein the Chinese medicine composition is made of the following raw materials:

[0040] 10-15 weight parts of Pinellia ternata, 6-15 weight parts of Scutellaria baicalensis, 10-15 weight parts of Poria cocos, 10-15 weight parts of stir-fried Atractylodes macrocephala, 6-15 weight parts of red ginseng, 3-6 weight parts of Coptis chinensis, 3-6 weight parts of roasted Licorice root, 3-6 weight parts of Carthamus tinctorius, 6-9 weight parts of dried ginger, 3-6 weight parts of jujube, 6-15 weight parts of Ophiopogon japonicus, 3-6 weight parts of ginger, and 10-15 weight parts of red ochre.

[0041] The method for preparing the above-mentioned Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome adopts the following steps:

[0042] S1. Crush the raw materials of the above-mentioned Chinese medicine composition, decoct them twice, filter them, discard the residues, and combine the decoctions from the two decoctions.

[0043] S2. Cool the soup to 35-39°C, adjust the pH to 7±0.5, and the humidity to 60%±5%. Inoculate the fermentation culture medium with a ratio of 2:1 between Bifidobacterium and Lactobacillus.

[0044] S3. The fermentation time is 84 hours. After the fermentation is completed, the Chinese medicine composition is obtained by inactivation, freeze-drying and pulverization.

[0045] S4. Add probiotics to the Chinese medicine composition and mix well to obtain granules of the Chinese medicine composition.

[0046] Specifically, the above-mentioned Chinese medicine composition granules are packaged in 10g bags, which are composed of 8g of the Chinese medicine composition, 0.5g of Lactobacillus gasseri LG-084, 0.5g of Lactobacillus ttyS-839 and 1g of inulin, and the number of viable probiotics in each bag of the Chinese medicine composition granules is greater than 10 9 .

[0047] Example 3

[0048] A Chinese medicine composition granule for preventing or treating high altitude gastrointestinal stress syndrome, wherein the Chinese medicine composition is made of the following raw materials:

[0049] 15 parts by weight of Pinellia ternata, 15 parts by weight of Scutellaria baicalensis, 15 parts by weight of Poria cocos, 15 parts by weight of stir-fried Atractylodes macrocephala, 15 parts by weight of red ginseng, 6 parts by weight of Coptis chinensis, 6 parts by weight of roasted Licorice root, 6 parts by weight of Safflower, 9 parts by weight of dried ginger, 6 parts by weight of jujube, 15 parts by weight of Ophiopogon japonicus, 6 parts by weight of ginger, and 15 parts by weight of red ochre.

[0050] The method for preparing the above-mentioned Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome adopts the following steps:

[0051] S1. Crush the raw materials of the above-mentioned Chinese medicine composition, decoct them twice, filter them, discard the residues, and combine the decoctions from the two decoctions.

[0052] S2. Cool the soup to 35-39°C, adjust the pH to 7±0.5, and the humidity to 60%±5%. Inoculate the fermentation culture medium with a ratio of 1:1 between Bifidobacterium and Lactobacillus.

[0053] S3. The fermentation time is 96 hours. After the fermentation is completed, the Chinese medicine composition is obtained by inactivation, freeze-drying and pulverization.

[0054] S4. Add probiotics to the Chinese medicine composition and mix well to obtain granules of the Chinese medicine composition.

[0055] Specifically, the above-mentioned Chinese medicine composition granules are packaged in 10g bags, which are composed of 8g of Chinese medicine composition, 1g of lactobacillus ttyS-839 and 1g of inulin, and the number of viable probiotics in each bag of Chinese medicine composition granules is greater than 10 9 .

[0056] The above are only preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for preventing or treating high altitude gastrointestinal stress syndrome, characterized in that: The Chinese medicine composition is made from the following raw materials: 10-15 weight parts of Pinellia ternata, 6-15 weight parts of Scutellaria baicalensis, 10-15 weight parts of Poria cocos, 10-15 weight parts of stir-fried Atractylodes macrocephala, 6-15 weight parts of red ginseng, 3-6 weight parts of Coptis chinensis, 3-6 weight parts of roasted Licorice root, 3-6 weight parts of Carthamus tinctorius, 6-9 weight parts of dried ginger, 3-6 weight parts of jujube, 6-15 weight parts of Ophiopogon japonicus, 3-6 weight parts of ginger, and 10-15 weight parts of red ochre.

2. The Chinese medicine composition for preventing or treating high altitude gastrointestinal stress syndrome according to claim 1, characterized in that: The Chinese medicine composition is made from the following raw materials: 12 parts by weight of Pinellia ternata, 10 parts by weight of Scutellaria baicalensis, 10 parts by weight of Poria cocos, 10 parts by weight of stir-fried Atractylodes macrocephala, 10 parts by weight of red ginseng, 3 parts by weight of Coptis chinensis, 5 parts by weight of roasted Licorice root, 6 parts by weight of Safflower, 6 parts by weight of dried ginger, 4 parts by weight of jujube, 10 parts by weight of Ophiopogon japonicus, 5 parts by weight of ginger, and 12 parts by weight of red ochre.

3. A Chinese medicine composition granule for preventing or treating high altitude gastrointestinal stress syndrome, characterized in that: The Chinese medicine composition comprising any one of claims 1 or 2 and probiotics.

4. The Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 3, characterized in that: The probiotics are Lactobacillus gasseri LG-084 and / or Lactobacillus ttyS-839.

5. The Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 3, characterized in that: The weight ratio of the Chinese medicine composition to the probiotics is 8-9:

1.

6. The Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 3, characterized in that: The invention also comprises inulin, wherein the weight ratio of the inulin to the probiotics is 1:

1.

7. The Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 3, characterized in that: The number of viable probiotic bacteria per 10g of Chinese medicine composition granules is greater than 10 9 .

8. A method for preparing the Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to any one of claims 3 to 7, characterized in that: Use the following steps: S1. Crush the raw materials of the above-mentioned Chinese medicine composition, decoct twice, filter, discard the residue, and combine the decoctions of the two decoctions; S2, cooling the soup to 35-39°C, adjusting the pH value to 7±0.5, and inoculating the fermentation culture medium; S3, the fermentation time is 72-96 hours, and after the fermentation is completed, the Chinese medicine composition is obtained by inactivation, drying and crushing; S4. Add probiotics to the Chinese medicine composition and mix well to obtain granules of the Chinese medicine composition.

9. The method for preparing the Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 8, characterized in that: The bacterial species in the fermentation culture medium in step S2 are bifidobacteria and lactobacilli.

10. The method for preparing the Chinese medicine composition granules for preventing or treating high altitude gastrointestinal stress syndrome according to claim 9, characterized in that: The bacterial species count ratio of bifidobacterium and lactobacillus is 2:1-1:1.