Chest sealing patch dressing and preparation method thereof

Abstract

The invention relates to the technical field of medical treatment, in particular to a chest sealing paste dressing and a preparation method thereof.The chest sealing paste dressing is prepared by mixing a monomer, a cross-linking agent, a photoinitiator, a neutralizer and a thickening agent according to the proportion and conducting mixing through magnetic stirring or mechanical stirring, and due to the fact that the preparation process is simple, and relatively harsh production equipment is not needed, the chest sealing paste dressing is prepared. Not only can the energy consumption in the production process be reduced, but also the requirements of industrial large-scale production can be met; the hydrogel solution obtained after cooling can be directly coated on a base material and can be rapidly formed through ultraviolet irradiation, tedious drying and curing steps are omitted, so that the production efficiency is greatly improved, and the hydrogel formed through illumination not only has good biocompatibility, but also has relatively large viscosity.

Description

Technical Field

[0001] The invention relates to the field of medical technology, and in particular to a chest sealing dressing and a preparation method thereof. Background Art

[0002] In the medical field, trauma treatment has always occupied a core position. In particular, chest trauma, such as open wounds, abrasions, contusions and postoperative wounds, occurs frequently, which puts higher demands on treatment methods. Although traditional dressings can meet basic coverage and protection needs, they still have many limitations. With the rapid development of materials science, hydrogels have successfully entered the field of trauma dressings with their unique properties, giving birth to trauma hydrogel chest seals. The chest seal uses the strong water absorption and water locking ability of hydrogels to create a warm and humid healing environment for the wound, which is very different from the traditional dry healing concept. The moist environment is like a natural hotbed, which greatly promotes cell migration and proliferation and accelerates wound healing.

[0003] However, the preparation of hydrogels can adopt the freeze-drying method mentioned in the prior art patent (CN118384319A). Although it can produce high-quality hydrogels, its manufacturing process is relatively complicated. The freeze-drying process requires strict control of key parameters such as temperature, pressure and drying time to ensure product quality. In addition, the freeze-drying method has a long production cycle, usually taking several hours or even days to complete a batch, which greatly limits the production efficiency of chest sealing dressings.

[0004] In addition, due to the extremely complex structure of the chest, the chest wall rises and falls, and the muscles are in dynamic activities all the time. The current trauma hydrogel chest seals are not yet able to accurately adapt to these complex characteristics in terms of design. Taking the side of the chest and the armpit as an example, the chest seals are often loosely fitted, and tiny gaps can be seen everywhere. External bacteria and pollutants take advantage of the opportunity to enter, causing the risk of wound infection to soar.

[0005] In summary, the chest sealing dressing in the prior art has the problems of complex production process, low production efficiency and poor adhesion. Summary of the invention

[0006] The object of the present invention is to provide a chest sealing dressing and a preparation method thereof, aiming to solve the technical problems of the chest sealing dressing in the prior art, such as complex production process, low production efficiency and poor viscosity.

[0007] To achieve the above object, the present invention adopts a chest sealing dressing, which includes 20%-80% of a monomer, 0.01%-1% of a cross-linking agent, 0.01%-2% of a photoinitiator, 10%-30% of a neutralizer and 10%-50% of a thickener.

[0008] The monomer is any one or more combinations of acrylic acid, methacrylic acid, 2-acrylamide-2-methylpropanesulfonic acid, (3-acrylamidepropyl)trimethylammonium chloride, methacrylate, N-vinylacetamide, N-vinylpyrrolidone, and N,N-dimethylacrylamide that can undergo cross-linking reaction.

[0009] The crosslinking agent is an ester that can undergo a crosslinking reaction with the monomer and contains an unsaturated double bond, such as one or more combinations of polyethylene glycol diacrylate, tripropylene glycol diacrylate, and dimethyl diacrylate.

[0010] Wherein, the photoinitiator is one of 1173, 1184, 1127, and 2959.

[0011] Wherein, the neutralizing agent is one or more combinations of sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and aminoacetic acid.

[0012] Wherein, the thickener is one or more combinations of propylene glycol, glycerol, sorbitol and polyethylene glycol.

[0013] The present invention also provides a method for preparing a chest sealing dressing, which is used to prepare the chest sealing dressing as described above. The steps include: First, prepare a hydrogel solution for later use; The hydrogel solution is coated on a substrate and shaped by ultraviolet light to obtain a hydrogel coil; The hydrogel roll is cut and packaged and then sterilized to obtain the chest sealing dressing.

[0014] Wherein, the method for preparing the hydrogel solution is as follows: Monomers, crosslinking agents, photoinitiators, neutralizers and thickeners are taken in proportion and put into a stirring device, and mixed by magnetic stirring or mechanical stirring, and then cooled to obtain a hydrogel solution.

[0015] Wherein, when magnetic stirring or mechanical stirring is adopted, the solution is continuously cooled.

[0016] The specific method of coating the hydrogel solution on the substrate and forming it by ultraviolet light to obtain the hydrogel coil is as follows: The cooled hydrogel solution was coated on a non-woven fabric at a light wavelength of 365 nm and a coating speed of 6 m / min to obtain a hydrogel coil.

[0017] The present invention discloses a chest sealing patch dressing and a preparation method thereof. The present invention firstly takes a monomer, a cross-linking agent, a photoinitiator, a neutralizing agent and a thickener according to a proportion, puts them into a stirring device, and mixes them by magnetic stirring or mechanical stirring. After cooling, a hydrogel solution is obtained. Then, the hydrogel solution is coated on a substrate and shaped by ultraviolet light to obtain a hydrogel coil. The hydrogel coil is cut and packaged, and then sterilized to obtain a chest sealing patch dressing. The present invention mixes monomers, crosslinking agents, photoinitiators, neutralizers and thickeners in proportion and mixes them by magnetic stirring or mechanical stirring. Since the preparation process is simple and relatively strict production equipment is not required, the energy consumption of the production process can be reduced and the requirements of industrialized scale-up production can be met. The hydrogel solution obtained after cooling can be directly coated on a substrate and quickly formed through ultraviolet light, eliminating the tedious drying and curing steps, thereby greatly improving production efficiency. The hydrogel formed by light not only has good biocompatibility, but also has greater viscosity. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a step flow chart of Example 1 of the present invention.

[0020] Figure 2 It is a step flow chart of Example 2 of the present invention.

[0021] Figure 3 It is a step flow chart of Example 3 of the present invention.

[0022] Figure 4 It is a step flow chart of Example 4 of the present invention.

[0023] Figure 5 It is a step flow chart of Example 5 of the present invention. DETAILED DESCRIPTION

[0024] Embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be construed as limiting the present invention.

[0025] The invention provides a chest sealing dressing, comprising 20%-80% of a monomer, 0.01%-1% of a cross-linking agent, 0.01%-2% of a photoinitiator, 10%-30% of a neutralizer and 10%-50% of a thickener.

[0026] The monomer is any one or more combinations of acrylic acid, methacrylic acid, 2-acrylamide-2-methylpropanesulfonic acid, (3-acrylamidepropyl)trimethylammonium chloride, methacrylate, N-vinyl acetamide, N-vinyl pyrrolidone, and N,N-dimethylacrylamide that can undergo cross-linking reaction.

[0027] The cross-linking agent is an ester that can undergo a cross-linking reaction with the monomer and contains an unsaturated double bond, such as one or more combinations of polyethylene glycol diacrylate, tripropylene glycol diacrylate, and dimethyl diacrylate.

[0028] The photoinitiator is one of 1173, 1184, 1127 and 2959.

[0029] The neutralizing agent is one or more combinations of sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and aminoacetic acid.

[0030] The thickener is one or more combinations of propylene glycol, glycerol, sorbitol and polyethylene glycol. The present invention also provides a method for preparing a chest sealing dressing, which is used to prepare the chest sealing dressing as described above. The steps include: First, prepare a hydrogel solution for later use; The hydrogel solution is coated on a substrate and shaped by ultraviolet light to obtain a hydrogel coil; The hydrogel roll is cut and packaged and then sterilized to obtain the chest sealing dressing.

[0031] Wherein, the method for preparing the hydrogel solution is as follows: Monomers, crosslinking agents, photoinitiators, neutralizers and thickeners are taken in proportion and put into a stirring device, and mixed by magnetic stirring or mechanical stirring, and then cooled to obtain a hydrogel solution.

[0032] Wherein, when magnetic stirring or mechanical stirring is adopted, the solution is continuously cooled.

[0033] The specific method of coating the hydrogel solution on the substrate and forming it by ultraviolet light to obtain the hydrogel coil is as follows: The cooled hydrogel solution was coated on a non-woven fabric at a light wavelength of 365 nm and a coating speed of 6 m / min to obtain a hydrogel coil. Example

[0034] See also Figure 1 , Figure 1 It is a step flow chart of Example 1 of the present invention.

[0035] In this embodiment, the preparation method of the chest sealing dressing is as follows: S1. First, 40% of 2-acrylamide-2-methylpropane sulfonic acid, 9% of ethylene glycol dimethacrylate, 0.5% of polyethylene glycol diacrylate, 0.5% of photoinitiator 2959, 10% of triethanolamine, 20% of glycerol, and 20% of propylene glycol are weighed in proportion and put into a stirring device and stirred until uniform; when the solution temperature is cooled to room temperature, a hydrogel solution is obtained; S2, coating the cooled hydrogel solution on the non-woven fabric, with the wavelength of light being 365 nm and the coating speed being 6 m / min, to obtain a hydrogel coil; S3, placing the hydrogel coil on a slitting machine for slitting, and packaging and sterilizing after slitting to obtain a hydrogel dressing.

[0036] The solution is continuously cooled during the stirring process. Example

[0037] See also Figure 2 , Figure 2 It is a step flow chart of Example 2 of the present invention.

[0038] In this embodiment, the preparation method of the chest sealing dressing is as follows: S1. First, weigh 20% of 2-acrylamide-2-methylpropanesulfonic acid, 28.5% of methacrylic acid, 0.5% of ethylene glycol dimethacrylate, 0.5% of polyethylene glycol diacrylate, 0.5% of photoinitiator I184, 10% of sodium hydroxide, and 40% of glycerol in proportion, put them into a stirring device and stir until uniform; wait for the solution temperature to cool to room temperature to obtain a hydrogel solution; S2, coating the cooled hydrogel solution on the non-woven fabric, with the light wavelength of 335nm and the coating speed of 4.5m / min to obtain a hydrogel coil; S3, placing the hydrogel coil on a slitting machine for slitting, and packaging and sterilizing after slitting to obtain a hydrogel dressing.

[0039] The solution is continuously cooled during the stirring process. Example

[0040] See also Figure 3 , Figure 3 It is a step flow chart of Example 3 of the present invention.

[0041] In this embodiment, the preparation method of the chest sealing dressing is as follows: S1. First, 38% of 2-acrylamide-2-methylpropanesulfonic acid, 10% of N-vinyl pyrrolidone, 1% of ethylene glycol dimethacrylate, 0.5% of photoinitiator 1173, 10.5% of potassium hydroxide, and 40% of glycerol are weighed in proportion and put into a stirring device and stirred until uniform; when the solution temperature is cooled to room temperature, a hydrogel solution is obtained; S2, coating the cooled hydrogel solution on the non-woven fabric, with the light wavelength of 385nm and the coating speed of 2m / min to obtain a hydrogel coil; S3, placing the hydrogel coil on a slitting machine for slitting, and packaging and sterilizing after slitting to obtain a hydrogel dressing.

[0042] The solution is continuously cooled during the stirring process. Example

[0043] See also Figure 4 , Figure 4 It is a step flow chart of Example 4 of the present invention.

[0044] In this embodiment, the preparation method of the chest sealing dressing is as follows: S1. First, weigh 29% of 2-acrylamide-2-methylpropanesulfonic acid, 10% of N-vinyl pyrrolidone, 0.5% of ethylene glycol dimethacrylate, 1.5% of photoinitiator 1173, 9% of potassium hydroxide, and 50% of glycerol according to proportion, put them into a stirring device and stir until uniform; wait for the solution temperature to cool to room temperature, and then obtain a hydrogel solution; S2, coating the cooled hydrogel solution on the non-woven fabric, with the light wavelength of 355nm and the coating speed of 3m / min to obtain a hydrogel coil; S3, placing the hydrogel coil on a slitting machine for slitting, and packaging and sterilizing after slitting to obtain a hydrogel dressing.

[0045] The solution is continuously cooled during the stirring process. Example

[0046] See also Figure 5 , Figure 5 It is a step flow chart of Example 5 of the present invention.

[0047] In this embodiment, the preparation method of the chest sealing dressing is as follows: S1. First, 40% of 2-acrylamide-2-methylpropanesulfonic acid, 20% of N-vinyl pyrrolidone, 0.5% of ethylene glycol dimethacrylate, 1.5% of photoinitiator 1173, 9% of potassium hydroxide, and 29% of glycerol are weighed in proportion and put into a stirring device and stirred until uniform; when the solution temperature is cooled to room temperature, a hydrogel solution is obtained; S2, coating the cooled hydrogel solution on the non-woven fabric, with the light wavelength of 355nm and the coating speed of 4m / min to obtain a hydrogel coil; S3, placing the hydrogel coil on a slitting machine for slitting, and packaging and sterilizing after slitting to obtain a hydrogel dressing.

[0048] The solution is continuously cooled during the stirring process.

[0049] The chest sealing patch dressing and the preparation method thereof of the present invention are as follows: firstly, monomers, crosslinking agents, photoinitiators, neutralizers and thickeners are taken in proportion and put into a stirring device for mixing by magnetic stirring or mechanical stirring, and then a hydrogel solution is obtained after cooling; then, the hydrogel solution is coated on a substrate and shaped by ultraviolet light to obtain a hydrogel coil; the hydrogel coil is cut and packaged and sterilized to obtain the chest sealing patch dressing; The present invention mixes monomers, crosslinking agents, photoinitiators, neutralizers and thickeners in proportion and mixes them by magnetic stirring or mechanical stirring. Since the preparation process is simple and relatively strict production equipment is not required, the energy consumption of the production process can be reduced and the requirements of industrialized scale-up production can be met. The hydrogel solution obtained after cooling can be directly coated on a substrate and quickly formed through ultraviolet light, eliminating the tedious drying and curing steps, thereby greatly improving production efficiency. The hydrogel formed by light not only has good biocompatibility, but also has greater viscosity.

[0050] What is disclosed above is only a preferred embodiment of the present invention, and it certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.

Claims

1. A chest sealing dressing, characterized in that: It includes 20%-80% monomer, 0.01%-1% cross-linking agent, 0.01%-2% photoinitiator, 10%-30% neutralizer and 10%-50% thickener.

2. The chest sealing dressing according to claim 1, characterized in that: The monomer is any one or more combinations of acrylic acid, methacrylic acid, 2-acrylamide-2-methylpropanesulfonic acid, (3-acrylamidepropyl)trimethylammonium chloride, methacrylate, N-vinyl acetamide, N-vinyl pyrrolidone, and N,N-dimethylacrylamide.

3. The chest sealing dressing according to claim 2, characterized in that: The cross-linking agent is one or more combinations of polyethylene glycol diacrylate, tripropylene glycol diacrylate, and dimethyl diacrylate.

4. The chest sealing dressing according to claim 3, characterized in that: The photoinitiator is one of 1173, 1184, 1127 and 2959.

5. The chest sealing dressing according to claim 4, characterized in that: The neutralizing agent is one or more combinations of sodium hydroxide, potassium hydroxide, sodium bicarbonate, hydrochloric acid, acetic acid, diethanolamine, triethanolamine, and aminoacetic acid.

6. The chest sealing dressing according to claim 5, characterized in that: The thickener is one or more combinations of propylene glycol, glycerol, sorbitol and polyethylene glycol.

7. A method for preparing a chest sealing dressing, used for preparing the chest sealing dressing as claimed in claim 6, characterized in that: The steps include: First, prepare a hydrogel solution for later use; The hydrogel solution is coated on a substrate and shaped by ultraviolet light to obtain a hydrogel coil; The hydrogel roll is cut and packaged and then sterilized to obtain the chest sealing dressing.

8. The method for preparing the chest sealing dressing according to claim 7, characterized in that: The hydrogel solution was prepared as follows: Monomers, crosslinking agents, photoinitiators, neutralizers and thickeners are taken in proportion and put into a stirring device, and mixed by magnetic stirring or mechanical stirring, and then cooled to obtain a hydrogel solution.

9. The method for preparing the chest sealing dressing according to claim 8, characterized in that: When using magnetic stirring or mechanical stirring, the solution is cooled continuously.

10. The method for preparing the chest sealing dressing according to claim 9, characterized in that: The specific method of coating the hydrogel solution on the substrate and forming it through ultraviolet light to obtain the hydrogel coil is as follows: The cooled hydrogel solution was coated on a non-woven fabric at a light wavelength of 365 nm and a coating speed of 6 m / min to obtain a hydrogel coil.

Images