A vibration stimulation therapy system

Abstract

A vibration stimulation therapy system includes: a first acquisition unit for acquiring a first set of electrical signals from the hand of the target object during stimulation therapy using initial vibration stimulation parameters; a second acquisition unit for acquiring a second set of electrical signals from the legs of the target object; a first analysis unit for quantitatively analyzing the signals in the first and second sets of electrical signals to obtain analysis results; a first adjustment unit for adjusting the initial vibration stimulation parameters based on the analysis results to obtain target vibration stimulation parameters; and a first control unit for performing vibration stimulation therapy on the target object using the target vibration stimulation parameters. This invention improves the therapeutic effect of vibration stimulation therapy by quantitatively evaluating and analyzing the electrical signal sets acquired during the stimulation therapy of the target object and dynamically adjusting the vibration stimulation parameters based on the analysis results.

Description

Technical Field

[0001] This invention relates to a non-invasive treatment system, and more particularly to a vibration stimulation treatment system. Background Technology

[0002] Coordinate reset (CR) stimulation is a pattern of stimulation that disrupts abnormal synchronization, inducing persistent desynchronization by modifying the structure and function of connections between neurons. Research has applied this pattern to vibration stimulation devices, resulting in the Coordinate Reset Vibration Stimulation (CR) system. This non-invasive treatment system uses weak, painless vibrational pulses delivered to the fingertips instead of electrical pulses delivered via implanted electrodes. Because the vibrational pulse input applied to the fingertips can be fed into the motor basal ganglia-thalamic cortex circuit through different projections, such as via the thalamus (Vc)-cortex (SI)-striatum, the system can specifically stimulate neurons, causing them to readjust and restore normal activity patterns, thereby alleviating motor impairments and improving quality of life.

[0003] Currently, clinical trials targeting coordinated repositioning vibration stimulation utilize a glove-like vibratory tactile stimulation device. This device has vibratory tactile stimulators (piezoelectric motors) fixed at the contact points with each fingertip (excluding the thumb). The glove is connected to a controller, which sends control signals to the vibratory tactile stimulators at each fingertip according to a pre-set CR stimulation pattern to achieve coordinated repositioning vibration stimulation. Patent application CN117481944A discloses a hand function rehabilitation system and control method, achieving finger function rehabilitation and brain function reshaping by combining multi-sensory stimulation with hand movements to implement mirror steps, emergency stop steps, electrical stimulation steps, vibration stimulation steps, and light stimulation steps. However, existing technologies use fixed vibration stimulation parameters for all target subjects, which cannot be adjusted. This may lead to significant individual differences in treatment effects among different target subjects, with some showing significant effects while others show little to no effect. Furthermore, existing products cannot provide objective and timely evaluation of treatment effects, preventing doctors, target subjects, and follow-up personnel from promptly understanding the efficacy and compliance, thus affecting treatment efficiency and accuracy.

[0004] Therefore, no effective solution has yet been proposed to address the problem of poor therapeutic effects of the aforementioned vibration stimulation therapy. Summary of the Invention

[0005] In order to overcome the shortcomings of the prior art, the present invention aims to provide a vibration stimulation therapy system that quantitatively evaluates and analyzes the electrical signal set collected during the stimulation therapy of the target object, and dynamically adjusts the vibration stimulation parameters in the vibration stimulation therapy system based on the analysis results, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target object.

[0006] To achieve the above objectives, the technical solution of the present invention is as follows:

[0007] A vibration stimulation therapy system, comprising:

[0008] The first acquisition unit 10 is used to acquire a first set of electrical signals of the hand of the target object during vibration stimulation therapy, when the target object is stimulated with initial vibration stimulation parameters. The first set of electrical signals includes at least: hand acceleration, hand angular velocity, hand posture signal, and hand electromyographic signal. The initial vibration stimulation parameters include at least an initial vibration frequency.

[0009] The second acquisition unit 20 is used to acquire a second set of electrical signals from the legs of the target object. The second set of electrical signals includes at least: the acceleration of the legs, the angular velocity of the gyroscope, and the attitude signal of the legs.

[0010] The first analysis unit 30 is used to perform quantization analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results;

[0011] The first adjustment unit 40 is used to adjust the initial vibration stimulation parameters according to the analysis results to obtain the target vibration stimulation parameters;

[0012] The first control unit 50 is used to perform vibration stimulation therapy on the target object using the target vibration stimulation parameters.

[0013] The first analysis unit 30 includes:

[0014] The first calculation module is used to monitor the movement symptoms of the target object based on the first set of electrical signals and the second set of electrical signals, and to calculate the score set of the target object, wherein the score set includes at least: tremor score, bradykinesia score, dyskinesia score and frozen gait score;

[0015] The first acquisition module is used to obtain the first motion score of the target object based on the tremor score, bradykinesia score, dyskinesia score, and frozen gait score.

[0016] The first adjustment unit 40 includes:

[0017] The first adjustment module is used to adjust the first vibration frequency based on the first motion score to obtain a second vibration frequency;

[0018] A first control module is used to stimulate the target object with the second vibration frequency and calculate the second motion score of the target object.

[0019] The second control module is used to repeatedly perform the operation of adjusting the second vibration frequency through the first adjustment module based on the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment. The target motion score of the target object is a minimum value, the vibration frequency corresponding to the target motion score is taken as the target vibration frequency, and the target object is stimulated and treated with the target vibration frequency until the vibration stimulation treatment cycle of the target object ends.

[0020] The first adjustment module includes a second acquisition module, used to add a preset frequency value to the first vibration frequency to obtain the second vibration frequency.

[0021] The second control module includes:

[0022] The first adjustment submodule is used to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is negative.

[0023] The second adjustment submodule is used to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is zero or positive.

[0024] The second control module also includes:

[0025] The third adjustment submodule is used to increase the second vibration frequency by a preset frequency value when the difference between the second motion score and the first motion score is negative.

[0026] The fourth adjustment submodule is used to reduce the second vibration frequency by a preset frequency value when the difference between the second motion score and the first motion score is zero or positive.

[0027] The system also includes:

[0028] The hand vibration stimulation module 60, controlled by the first control unit 50, provides vibration stimulation to the hand; it includes: a controller, a sensor unit, an amplifier unit, and a motor array unit;

[0029] The leg vibration stimulation module 70, controlled by the first control unit 50, provides vibration stimulation to the legs; it includes: a controller, a sensor unit, an amplifier unit, and a motor array unit.

[0030] The hand vibration stimulation module 60 or the leg vibration stimulation module 70 specifically includes:

[0031] The receiving unit is configured to receive a set of vibration stimulation parameters before stimulating the target object with the initial vibration stimulation parameters, wherein the set of vibration stimulation parameters includes at least the following vibration stimulation parameters: single sequence stimulation frequency, motor vibration stimulation frequency, duration of vibration stimulation of a single finger within each stimulation cycle, number of consecutive stimulation open cycles, and number of consecutive stimulation close cycles.

[0032] The determining unit is used to determine the initial vibration stimulation parameters based on the set of vibration stimulation parameters;

[0033] A generation unit is used to generate an initial vibration control signal based on the initial vibration stimulation parameters;

[0034] The first transmission unit is used to transmit the initial vibration control signal to the controller of each vibration stimulation module via Bluetooth;

[0035] The second transmission unit is used to transmit the initial vibration control signal to the amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

[0036] Furthermore, the system also includes:

[0037] The first calculation unit is used to calculate the difference between the motion score of the target object after the second treatment and the motion score before the first treatment within each day during the vibration stimulation therapy, and obtain N score differences, where N is the number of treatment days during the vibration stimulation therapy.

[0038] The acquisition unit is used to acquire the initial motion score of the target object before the vibration stimulation treatment period and the final motion score of the target object after the vibration stimulation treatment period.

[0039] The second calculation unit is used to calculate the benefit value of the target object during vibration stimulation therapy based on the preset weight value, the N score differences, the initial motion score and the final motion score.

[0040] The second analysis unit is used to analyze the therapeutic effect of vibration stimulation on the target object based on the benefit value.

[0041] The vibration stimulation therapy system is used for the non-invasive treatment of Parkinson's disease and / or essential tremor.

[0042] Compared with the prior art, the advantages of the present invention are:

[0043] (1) The present invention is based on the acceleration of the hand, the angular velocity of the hand, the posture signal of the hand, and the electromyographic signal of the hand in the first set of electrical signals, and the acceleration of the leg, the angular velocity of the gyroscope, and the posture signal of the leg in the second set of electrical signals; the signals of the two sets of electrical signals are quantified and analyzed to obtain the analysis results, and the initial vibration stimulation parameters are adjusted to obtain the target vibration stimulation parameters; vibration stimulation therapy is performed, which solves the problem of poor treatment effect of vibration stimulation therapy in related technologies.

[0044] (2) The first adjustment unit of the present invention realizes the dynamic adjustment of the vibration stimulation parameters in the vibration stimulation therapy system, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target object.

[0045] In summary, this invention quantifies and analyzes the electrical signals collected during the stimulation treatment of the target object, and dynamically adjusts the vibration stimulation parameters in the vibration stimulation treatment system based on the analysis results, thereby improving the therapeutic effect of vibration stimulation treatment and achieving the best therapeutic effect for the target object. Attached Figure Description

[0046] Figure 1 This is a schematic diagram of the vibration stimulation therapy system of the present invention.

[0047] Figure 2 This is a schematic diagram of the vibration stimulation parameter adjustment of the present invention.

[0048] Figure 3 This is a schematic diagram showing how the target subject wears the hand vibration stimulation module and the leg vibration stimulation module.

[0049] Figure 4 This is a schematic diagram of an optional vibration stimulation therapy system provided according to an embodiment of the present invention. Detailed Implementation

[0050] The present invention will now be described in detail with reference to the accompanying drawings.

[0051] Figure 1 This is a flowchart of a vibration stimulation therapy system provided according to an embodiment of the present invention, such as... Figure 1 As shown, a vibration stimulation therapy system includes:

[0052] The first acquisition unit 10 is used to acquire a first set of electrical signals of the hand of the target object during vibration stimulation therapy, when the target object is stimulated with initial vibration stimulation parameters. The first set of electrical signals includes at least: hand acceleration, hand angular velocity, hand posture signal, and hand electromyographic signal. The initial vibration stimulation parameters include at least an initial vibration frequency.

[0053] The second acquisition unit 20 is used to acquire a second set of electrical signals from the legs of the target object. The first set of electrical signals includes at least: the acceleration of the legs, the angular velocity of the gyroscope, and the posture signal of the legs.

[0054] The first analysis unit 30 is used to perform quantization analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results;

[0055] The first adjustment unit 40 is used to adjust the initial vibration stimulation parameters according to the analysis results to obtain the target vibration stimulation parameters;

[0056] The first control unit 50 is used to perform vibration stimulation therapy on the target object using the target vibration stimulation parameters.

[0057] The aforementioned vibration stimulation therapy system quantifies and analyzes the electrical signals collected during the stimulation therapy of the target object, and dynamically adjusts the vibration stimulation parameters in the system based on the analysis results, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target object.

[0058] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the first analysis unit 30 further includes:

[0059] The first calculation module is used to monitor the movement symptoms of the target object based on the first set of electrical signals and the second set of electrical signals, and to calculate the score set of the target object, wherein the score set includes at least: tremor score, bradykinesia score, dyskinesia score and frozen gait score;

[0060] The first acquisition module is used to obtain the first motion score of the target object based on the tremor score, bradykinesia score, dyskinesia score, and frozen gait score.

[0061] In the above scheme, a first set of electrical signals from the target subject's hands and a second set of electrical signals from his / her legs are collected. These signals are then fused and analyzed to monitor the target subject's motor symptoms in daily life (e.g., a target subject with Parkinson's disease). Several indicators, including tremor, bradykinesia, dissociative symptoms, and freezing of gait, are quantitatively assessed. The resulting analysis of the target subject is the first motor score.

[0062] The above method allows for accurate and rapid analysis of the first motion score based on the electrical signal set of the target object, enabling more accurate subsequent adjustments to the vibration stimulation parameters of the target object.

[0063] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the first adjustment unit 40 includes:

[0064] The first adjustment module is used to adjust the first vibration frequency based on the first motion score to obtain a second vibration frequency;

[0065] A first control module is used to stimulate the target object with the second vibration frequency and calculate the second motion score of the target object.

[0066] The second control module is used to repeatedly perform the operation of adjusting the second vibration frequency through the first adjustment module based on the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment. The target motion score of the target object is a minimum value, the vibration frequency corresponding to the target motion score is taken as the target vibration frequency, and the target object is stimulated and treated with the target vibration frequency until the vibration stimulation treatment cycle of the target object ends.

[0067] like Figure 2 As shown, for example, fburst_t-1 is the first vibration frequency mentioned above, and the first motion score at the first vibration frequency is Sdt-1. The first vibration frequency is adjusted based on the first motion score to obtain the second vibration frequency (fburst_t). It should be noted that adjusting the first vibration frequency can be done by increasing or decreasing fburst_t-1 by 20Hz. The second vibration frequency is then used to stimulate the target object, and the second motion score of the target object (corresponding to...) is calculated. Figure 2If Sdt - Sdt-1 > 0, the first vibration frequency is adjusted by increasing it by 20Hz from fburst_t-1, and the second vibration frequency is adjusted by decreasing it by 20Hz from fburst_t-1. If Sdt - Sdt-1 > 0, the first vibration frequency is adjusted by decreasing it by 20Hz from fburst_t-1, and the second vibration frequency is adjusted by increasing it by 20Hz from fburst_t-1. If Sdt - Sdt-1 ≤ 0, the first vibration frequency is adjusted by increasing it by 20Hz from fburst_t-1, and the second vibration frequency is adjusted by increasing it by 20Hz from fburst_t-1. If Sdt - Sdt-1 ≤ 0, the first vibration frequency is adjusted by decreasing it by 20Hz from fburst_t-1, and the second vibration frequency is adjusted by decreasing it by 20Hz from fburst_t-1. The target object is stimulated and treated using an adjusted second vibration frequency. The third motion score of the target object is calculated. The operation of adjusting the vibration frequency is repeated until the target motion score of the target object is minimized (i.e., Sdmin = Sdt). The vibration frequency corresponding to the target motion score (Sdt) is taken as the target vibration frequency (fburst_t), and the target object is stimulated and treated using the target vibration frequency until the vibration stimulation treatment cycle of the target object ends.

[0068] The above scheme enables dynamic adjustment of vibration stimulation parameters in the vibration stimulation therapy system, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target subject.

[0069] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the second control module includes:

[0070] The first adjustment submodule is used to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is negative.

[0071] The second adjustment submodule is used to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is zero or positive.

[0072] For example, if the difference between the second motion score and the first motion score is negative, the second vibration frequency is adjusted in the same direction as the first vibration frequency. For example, if Sdt-Sdt-1 < 0, the first vibration frequency is adjusted by increasing it by 20Hz based on fburst_t-1, and the second vibration frequency is adjusted by increasing it by 20Hz based on fburst_t-1; if the first vibration frequency is adjusted by decreasing it by 20Hz based on fburst_t-1, the second vibration frequency is adjusted by decreasing it by 20Hz based on fburst_t-1.

[0073] If the difference between the second motion score and the first motion score is zero or positive, the second vibration frequency is adjusted in the opposite direction to the adjustment direction of the first vibration frequency. For example, if Sdt-Sdt-1≥0, the first vibration frequency is adjusted by increasing the first vibration frequency by 20Hz based on fburst_t-1, and the second vibration frequency is adjusted by decreasing the second vibration frequency by 20Hz based on fburst_t-1; if the first vibration frequency is adjusted by decreasing the second vibration frequency by 20Hz based on fburst_t-1, the second vibration frequency is adjusted by increasing the second vibration frequency by 20Hz based on fburst_t-1.

[0074] The above scheme ensures that the vibration stimulation parameters in the vibration stimulation therapy system are dynamically adjusted in a timely manner based on the difference between the second motion score and the first motion score, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target subject.

[0075] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the first adjustment module includes: a second acquisition module, used to add a preset frequency value to the first vibration frequency to obtain the second vibration frequency.

[0076] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the second control module includes: a third adjustment submodule, used to increase the second vibration frequency by the preset frequency value when the difference between the second motion score and the first motion score is negative; and a fourth adjustment submodule, used to decrease the second vibration frequency by the preset frequency value when the difference between the second motion score and the first motion score is zero or positive.

[0077] If a preset frequency value is added to the first vibration frequency (fburst_t-1) to obtain the second vibration frequency (fburst_t), and if Sdt-Sdt-1 < 0, then the adjustment of the second vibration frequency is to increase it by 20Hz based on fburst_t-1; if Sdt-Sdt-1 ≥ 0, then the adjustment of the second vibration frequency is to decrease it by 20Hz based on fburst_t-1.

[0078] The above scheme ensures that the vibration stimulation parameters in the vibration stimulation therapy system are dynamically adjusted in a timely manner based on the difference between the second motion score and the first motion score, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target subject.

[0079] Optionally, in the vibration stimulation therapy system provided in the embodiments of the present invention, the vibration stimulation therapy system further includes: a hand vibration stimulation module 60 and a leg vibration stimulation module 70, wherein each vibration stimulation module includes at least: a power management unit, a controller, a sensor unit, an amplifier unit and a motor array unit.

[0080] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the system further includes: a receiving unit, configured to receive a set of vibration stimulation parameters before stimulating the target object with the initial vibration stimulation parameters, wherein the set of vibration stimulation parameters includes at least the following vibration stimulation parameters: single sequence stimulation frequency, motor vibration stimulation frequency, duration of vibration stimulation of a single finger within each stimulation cycle, number of consecutive stimulation on cycles, and number of consecutive stimulation off cycles; a determining unit, configured to determine the initial vibration stimulation parameters based on the set of vibration stimulation parameters; a generating unit, configured to generate an initial vibration control signal based on the initial vibration stimulation parameters; a first transmission unit, configured to transmit the initial vibration control signal to the controller of each vibration stimulation module via Bluetooth; and a second transmission unit, configured to transmit the initial vibration control signal to an amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

[0081] Optionally, the vibration stimulation therapy system provided in this embodiment of the invention consists of a motion symptom analysis subsystem and a vibration stimulation subsystem, such as... Figure 4 As shown.

[0082] The motor symptom analysis subsystem collects acceleration, angular velocity, posture, and electromyography signals from the wrist of the target subject, as well as acceleration, gyroscope, and posture signals from the leg. After fusion analysis, it monitors the motor symptoms of Parkinson's disease target subjects in their daily lives and quantifies and assesses several indicators such as tremor, bradykinesia, dissociative symptoms, and freezing of gait.

[0083] The vibration stimulation subsystem consists of a hand vibration stimulation module and a leg vibration stimulation module. Each vibration stimulation module comprises a power management unit, a controller, an amplifier unit, and a motor array unit. The hand vibration stimulation modules are worn on the left and right hands, with a piezoelectric vibration motor fixed at the contact point with each finger. The leg vibration stimulation modules are worn on the left and right ankles, and multiple piezoelectric vibration motors are fixed around them. The switching mode of each vibration motor is independently controlled by the controller in its respective vibration stimulation module.

[0084] The motor symptom analysis subsystem dynamically adjusts stimulation parameters based on assessments of the wearer's improvement in motor symptoms during treatment and transmits these parameters via Bluetooth to the controller of each vibration stimulation module. These stimulation parameters are used to control the vibration signals generated by the vibration stimulation modules and include the single-sequence stimulation frequency f. sequence Motor vibration stimulation frequency f burst And the duration t of vibration stimulation of a single finger within each stimulation cycle. cont Number of consecutive stimulation cycles n on and the number of consecutive stimulation cycles n off The controller generates vibration control signals based on these received parameters, which are then applied to each amplifier in the amplifier unit. This drives the motors in each part to vibrate according to the control signals, achieving coordinated repositioning vibration stimulation of the peripheral nerves. The motor symptom quantitative evaluation system continuously and dynamically adjusts the stimulation parameters in the vibration stimulation system based on the wearer's motor function evaluation results to achieve the best therapeutic effect for individualized target subjects.

[0085] The above approach achieves precise control of vibration stimulation on the target object, thereby improving the therapeutic effect of vibration stimulation therapy and achieving the best therapeutic effect for the target object.

[0086] Additionally, it should be noted that, for ease of wear, each system and module is powered independently and transmits data wirelessly. The motor symptom analysis subsystem, serving as the host of the entire closed-loop coordinated resetting vibration stimulation system, communicates with the left and right hand vibration stimulation modules and the left and right leg vibration stimulation modules via Bluetooth.

[0087] Optionally, in the vibration stimulation therapy system provided in this embodiment of the invention, the system further includes: a first calculation unit, used to calculate the difference between the movement score of the target object after the second treatment and the movement score before the first treatment within each day during the vibration stimulation therapy period, to obtain N score differences, where N is the number of treatment days during the vibration stimulation therapy period; an acquisition unit, used to acquire the initial movement score of the target object before the vibration stimulation therapy period and the final movement score of the target object after the vibration stimulation therapy period; a second calculation unit, used to calculate the benefit value of the target object during the vibration stimulation therapy period based on a preset weight value, the N score differences, the initial movement score and the final movement score; and a second analysis unit, used to analyze the therapeutic effect of the vibration stimulation therapy on the target object based on the benefit value.

[0088] On the initial treatment day of the target subject, treatment is performed using preset vibration stimulation parameters. Subsequently, the stimulation parameters in the vibration stimulation system are dynamically adjusted daily based on the analysis results of the symptom evaluation system, and the improvement of the target subject's motor state is continuously evaluated. Then, based on multiple sets of motor state evaluation results, the date with the best therapeutic effect and the corresponding combination of stimulation parameters are found. This combination of stimulation parameters is used as the treatment parameters in the subsequent formal treatment period, and the efficacy evaluation of the treatment period is given after the treatment ends.

[0089] Specifically, the target subjects receive VCR treatment twice daily via a vibration stimulation system, while a symptom evaluation system continuously monitors their motor symptoms and calculates their daily motor scores. The sum of the scores for tremor, bradykinesia, dyskinesia, and frozen gait after the second vCR treatment on the same day is calculated as shown in Formula 1. A record is generated daily as a short-term / acute evaluation score for the treatment.

[0090]

[0091] One month later, n records are obtained, and the scores (s) for these n sports are calculated. d Summing and averaging, as shown in Formula 3, yields s. m and s m_ave Two values ​​serve as scores for the phased evaluation of treatment.

[0092]

[0093] Vibration frequency f burst Parameter adjustment

[0094] The daily exercise score is obtained based on Formula 1. As a result, the vibration frequency f was adjusted daily. burst Adjustments were made to find the vibration frequency f that would achieve the best therapeutic effect for VCR treatment. burstThe specific implementation steps are as follows:

[0095] (1) Obtain the athletic score for the first day. and the initial vibration frequency f burst_1 (250Hz)

[0096] (2) During the second day of VCR treatment, the vibration frequency f burst_2 If the frequency decreases or increases by 20Hz compared to the initial vibration frequency, calculate the frequency at the current vibration frequency f. burst_2 The second day's sports score

[0097] (3) If This indicates that the VCR treatment on that day had a certain therapeutic effect. Therefore, using the same method as the previous adjustment of the vibration frequency, continue to decrease or increase it by 20Hz, and calculate the current vibration frequency f. burst_3 Third day of exercise score like This indicates that the target's motor symptoms did not improve to any extent on that day, meaning the current vibration frequency f... burst_2 This is not the optimal vibration frequency, therefore, the method used to adjust the vibration frequency is reversed from the previous adjustment, starting at the initial vibration frequency f. burst_1 Based on the above, increase or decrease by 20Hz, and calculate the frequency at the current vibration frequency f. burst_3 Third day of exercise score The parameter adjustment process in this step can be summarized as Formula 4.

[0098]

[0099] (4) Repeat step three until the exercise score on day m drops to its lowest value. The vibration frequency f obtained at this time burst_m As the optimal vibration frequency, calculate the vibration frequency f at the current vibration frequency. burst_m Exercise score on day m Stop adjusting the vibration frequency parameters and use the optimal vibration frequency for subsequent vCR treatments until this stage of treatment is completed.

[0100] During the treatment period, the time after the second VCR treatment each day is calculated. Compared to the first VCR treatment on that day The score difference Δd i After the treatment period ends, the overall benefit GI of the target subject during the treatment period (corresponding to the benefit value mentioned above) is calculated according to formula (4) to achieve an objective evaluation index of the therapeutic effect of the target subject during the treatment period, where w is the benefit weight index and n is the number of days in the treatment period.

[0101]

[0102] During the treatment cycle, the vibration stimulation system is controlled by the symptom evaluation system. The vibration stimulation system records each on / off cycle and sends the data to the symptom evaluation system to generate treatment compliance statistics.

[0103] The above approach enables a more accurate analysis and evaluation of the therapeutic effect of vibration stimulation on the target object.

[0104] The vibration stimulation therapy system provided in this embodiment of the invention is essentially a closed-loop coordinated repositioning vibration stimulation therapy system, which can be used for non-invasive treatment of Parkinson's disease and / or essential tremor.

[0105] The vibration stimulation therapy system includes a processor and a memory. The first acquisition unit, the second acquisition unit, the first analysis unit, the first adjustment unit, and the first control unit mentioned above are all stored in the memory as program units. The processor executes the program units stored in the memory to realize the corresponding functions.

[0106] The processor contains a kernel, which retrieves the corresponding program unit from memory. One or more kernels can be configured, and adjusting kernel parameters can enhance the therapeutic effect of vibration stimulation therapy.

[0107] The memory may include non-permanent memory in computer-readable media, such as random access memory (RAM) and / or non-volatile memory, such as read-only memory (ROM) or flash RAM, and the memory includes at least one memory chip.

[0108] This invention provides a computer-readable storage medium storing a program thereon, which, when executed by a processor, implements the vibration stimulation therapy system.

[0109] This invention provides a processor for running a program, wherein the program executes the vibration stimulation therapy system during operation.

[0110] It will be understood by those skilled in the art that embodiments of the present invention may be provided as methods, systems, or computer program products. Thus, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware. Furthermore, the present invention may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to magnetic disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0111] This invention is described in accordance with flowcharts and / or block diagrams of methods, apparatus (systems), and computer program products. It will be understood that each block of the flowcharts and / or block diagrams, and combinations of blocks in the flowcharts and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, special-purpose computer, embedded processor, or other programmable data processing device to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing device, generate instructions for implementing the flowcharts and / or block diagrams. Figure 1 a process or multiple processes and / or boxes Figure 1 A device that provides the functions specified in one or more boxes.

[0112] These computer program instructions may also be stored in a computer readable memory that can direct a computer or other programmable data processing device to work in a specific manner, so that the instructions stored in the computer readable memory produce an article of manufacture comprising an instruction device, which implements the process Figure 1 a process or multiple processes and / or boxes Figure 1 The function specified in one or more boxes.

[0113] These computer program instructions can also be loaded onto a computer or other programmable data processing device so that a series of operational steps are executed on the computer or other programmable device to produce a computer-implemented process, thereby providing the instructions executed on the computer or other programmable device for implementing the process. Figure 1 a process or multiple processes and / or boxes Figure 1 A step that specifies a function in one or more boxes.

[0114] In a typical configuration, a computing device includes one or more processors (CPU), input / output interfaces, network interfaces, and memory.

[0115] Memory may include non-persistent memory in computer-readable media, such as random access memory (RAM) and / or non-volatile memory, such as read-only memory (ROM) or flash RAM. Memory is an example of computer-readable media.

[0116] Computer-readable media includes permanent and non-permanent, removable and non-removable media that can be implemented by any method or technology to store information. The information can be computer-readable instructions, data structures, program modules or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disc read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or any other non-transmission media that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include transitory computer-readable media (transitory media), such as modulated data signals and carrier waves.

[0117] It should also be noted that the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0118] Those skilled in the art will understand that embodiments of the present invention can be provided as methods, systems, or computer program products. Therefore, the present invention can take the form of a completely hardware embodiment, a completely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention can take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0119] The above are merely embodiments of the present invention and are not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principle of the present invention should be included within the scope of the claims of the present invention.

Claims

1. A vibration stimulation therapy system, characterized in that, include: The first acquisition unit (10) is used to acquire a first set of electrical signals of the hand of the target object during the vibration stimulation therapy process of stimulating the target object with initial vibration stimulation parameters. The first set of electrical signals includes at least: hand acceleration, hand angular velocity, hand posture signal, and hand electromyographic signal. The initial vibration stimulation parameters include at least a first vibration frequency. The second acquisition unit (20) is used to acquire a second set of electrical signals of the target object's legs. The second set of electrical signals includes at least: the acceleration of the legs, the angular velocity of the gyroscope, and the attitude signal of the legs. The first analysis unit (30) is used to perform quantization analysis on the signals in the first electrical signal set and the second electrical signal set to obtain analysis results; The first adjustment unit (40) is used to adjust the initial vibration stimulation parameters according to the analysis results to obtain the target vibration stimulation parameters; The first control unit (50) is used to perform vibration stimulation therapy on the target object using the target vibration stimulation parameters; The first analysis unit (30) includes: The first calculation module is used to monitor the movement symptoms of the target object based on the first set of electrical signals and the second set of electrical signals, and to calculate the score set of the target object, wherein the score set includes at least: tremor score, bradykinesia score, dyskinesia score and frozen gait score; The first acquisition module is used to obtain the first motion score of the target object based on the tremor score, bradykinesia score, dyskinesia score, and frozen gait score.

2. The vibration stimulation therapy system according to claim 1, characterized in that, The first adjustment unit (40) includes: The first adjustment module is used to adjust the first vibration frequency based on the first motion score to obtain a second vibration frequency; A first control module is used to stimulate the target object with the second vibration frequency and calculate the second motion score of the target object. The second control module is used to repeatedly perform the operation of adjusting the second vibration frequency through the first adjustment module based on the difference between the second motion score and the first motion score, until the adjusted vibration frequency is used for treatment. The target motion score of the target object is a minimum value, the vibration frequency corresponding to the target motion score is taken as the target vibration frequency, and the target object is stimulated and treated with the target vibration frequency until the vibration stimulation treatment cycle of the target object ends.

3. The vibration stimulation therapy system according to claim 2, characterized in that, The first adjustment module includes a second acquisition module, used to add a preset frequency value to the first vibration frequency to obtain the second vibration frequency.

4. The vibration stimulation therapy system according to claim 3, characterized in that, The second control module includes: The first adjustment submodule is used to adjust the second vibration frequency in the same direction as the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is negative. The second adjustment submodule is used to adjust the second vibration frequency in a direction opposite to the adjustment direction of the first vibration frequency when the difference between the second motion score and the first motion score is zero or positive.

5. The vibration stimulation therapy system according to claim 4, characterized in that, The second control module also includes: The third adjustment submodule is used to increase the second vibration frequency by a preset frequency value when the difference between the second motion score and the first motion score is negative. The fourth adjustment submodule is used to reduce the second vibration frequency by a preset frequency value when the difference between the second motion score and the first motion score is zero or positive.

6. The vibration stimulation therapy system according to claim 5, characterized in that, The system also includes: The hand vibration stimulation module (60) and the controlled first control unit (50) provide vibration stimulation to the hand; include: controller, sensor unit, amplifier unit and motor array unit; The leg vibration stimulation module (70) and the controlled first control unit (50) provide vibration stimulation to the legs; including: controller, sensor unit, amplifier unit and motor array unit.

7. The system according to claim 6, characterized in that, The hand vibration stimulation module (60) or leg vibration stimulation module (70) specifically includes: The receiving unit is configured to receive a set of vibration stimulation parameters before stimulating the target object with the initial vibration stimulation parameters, wherein the set of vibration stimulation parameters includes at least the following vibration stimulation parameters: single sequence stimulation frequency, motor vibration stimulation frequency, duration of vibration stimulation of a single finger within each stimulation cycle, number of consecutive stimulation open cycles, and number of consecutive stimulation close cycles. The determining unit is used to determine the initial vibration stimulation parameters based on the set of vibration stimulation parameters; A generation unit is used to generate an initial vibration control signal based on the initial vibration stimulation parameters; The first transmission unit is used to transmit the initial vibration control signal to the controller of each vibration stimulation module via Bluetooth; The second transmission unit is used to transmit the initial vibration control signal to the amplifier unit in each vibration stimulation module through the controller of each vibration stimulation module, so as to drive the motor array unit in each vibration stimulation module to vibrate through the initial vibration control signal of the amplifier unit.

8. The vibration stimulation therapy system according to claim 7, characterized in that, Place The system also includes: The first calculation unit is used to calculate the difference between the motion score of the target object after the second treatment and the motion score before the first treatment within each day during the vibration stimulation therapy, and obtain N score differences, where N is the number of treatment days during the vibration stimulation therapy. The acquisition unit is used to acquire the initial motion score of the target object before the vibration stimulation treatment period and the final motion score of the target object after the vibration stimulation treatment period. The second calculation unit is used to calculate the benefit value of the target object during vibration stimulation therapy based on the preset weight value, the N score differences, the initial motion score and the final motion score. The second analysis unit is used to analyze the therapeutic effect of vibration stimulation on the target object based on the benefit value.

9. The system according to claim 1, characterized in that, The vibration stimulation therapy system is used for the non-invasive treatment of Parkinson's disease and / or essential tremor.

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