Medicine mixing device

Abstract

The invention discloses a medicine mixing device, and belongs to the technical field of medicine mixing. The medicine mixing device comprises a medicine mixing tank and a stirring mechanism arranged in the medicine mixing tank, the stirring mechanism does circular motion around the longitudinal axis of the medicine mixing tank, and the stirring mechanism comprises a stirring rod which is obliquely arranged so that the bottom end of the stirring rod can be close to the inner wall of the medicine mixing tank; the supporting rods are arranged in the length direction of the stirring rod and are horizontally arranged, the stirring paddle comprises a spiral blade, a first spiral belt and a second spiral belt, the spiral blade is fixedly arranged on the stirring rod in a winding mode, the first spiral belt and the second spiral belt are evenly distributed on the periphery of the stirring rod, the rotating directions of the first spiral belt and the second spiral belt are opposite, and the first spiral belt and the second spiral belt are parallel to each other. The radiuses of the spiral lines are gradually reduced from bottom to top. According to the medicine mixing device, three-dimensional flow of mixed medicine can be generated, flow of the medicine in the axial direction, the radial direction and the tangential direction is improved, rotating force of a central area is balanced, and vortex and high shear force of the central area are reduced.

Description

Technical Field

[0001] The invention relates to the technical field of drug mixing, and in particular to a drug mixing device. Background Art

[0002] In clinical treatment, precise mixing and efficient preparation of drugs are key links to ensure that patients receive accurate treatment. With the continuous advancement of medical technology and the increasing number of drug types, higher requirements are placed on the performance and functions of drug mixing devices. Their quality and efficiency directly affect the quality and efficacy of the final drug.

[0003] In the traditional hospital drug mixing process, the diversity and complexity of drug ingredients make mixing uniformity a huge challenge. Different drug ingredients may have different physical properties, such as density, particle size, viscosity, etc., which may lead to stratification and agglomeration during mixing, affecting the consistency and efficacy of the drug. In the operation of existing mixing devices, common manual stirring or simple mechanical stirring devices may generate vortices during the stirring process. The vortices not only cause excessive mixing of drugs in local areas, destroying the overall uniformity, but also generate excessive shear force to damage the active ingredients of certain sensitive drugs, especially for complex drug formulations and high-demand preparations, such as the mixing of multiple drugs in intravenous infusion, the preparation of nutrient solutions, certain vitamins and protein drugs, peptide drugs and gene therapy drugs and other macromolecular bioactive substances. The molecular structure of these drugs plays a decisive role in their biological activity and efficacy. Once damaged by shear force, the targeting and controlled release effects of the drugs may be reduced, seriously reducing the quality of the drugs. Summary of the invention

[0004] The purpose of the present invention is to overcome the problems in the prior art and provide a drug mixing device that can finely control the stirring process, reduce drug damage, and improve drug mixing efficiency and uniformity.

[0005] The technical solution of the present invention is:

[0006] A medicine mixing device comprises a medicine mixing tank and a stirring mechanism arranged in the medicine mixing tank, the stirring mechanism making a circular motion around the longitudinal axis of the medicine mixing tank, the stirring mechanism comprising: a stirring rod arranged obliquely so that the bottom end of the stirring rod approaches the inner wall of the medicine mixing tank; a plurality of support rods arranged along the length direction of the stirring rod, the plurality of support rods are arranged horizontally, and the lengths of the plurality of support rods decrease from bottom to top along the length direction of the stirring rod; a stirring paddle comprising a spiral blade, a first spiral belt and a second spiral belt, the spiral blade is wound and fixed on the stirring rod, the first spiral belt and the second spiral belt are distributed around the stirring rod, the first spiral belt and the second spiral belt have opposite rotation directions, the spiral line radius of the first spiral belt and the second spiral belt gradually decreases from bottom to top, the tops of the first spiral belt and the second spiral belt are respectively fixedly connected to the stirring rod, and the bottoms of the first spiral belt and the second spiral belt are respectively fixedly connected to the two ends of the support rod at the bottom.

[0007] Furthermore, a plurality of guide plates are provided on the upper surfaces of the first spiral belt and the second spiral belt, and the plurality of guide plates have an inclination angle with the upper surfaces of the first spiral belt and the second spiral belt.

[0008] Furthermore, the width of the guide plate is smaller than the width of the first spiral belt and the second spiral belt at the location.

[0009] Furthermore, the angle between the stirring rod and the longitudinal axis is 5-20°.

[0010] Furthermore, the inclination angles of the guide plate and the upper surfaces of the first spiral belt and the second spiral belt are 10-45°.

[0011] Furthermore, the first spiral ribbon and the second spiral ribbon are symmetrically distributed on the stirring rod.

[0012] Furthermore, the number of the support rods is 3-5, the number of spiral turns of the first spiral belt and the second spiral belt is 3-5, and the connection between the rotation diameters of two adjacent spiral belts is connected to the end of the support rod.

[0013] Furthermore, a driving mechanism is provided above the stirring rod for driving the stirring rod to perform circular motion around the longitudinal axis, the driving mechanism includes a driving member and a gear transmission assembly, the gear transmission assembly includes a driving gear and a driven gear, the output end of the driving member is connected to the driving gear through a coupling, the radius of the driving gear is larger than the radius of the driven gear, the driving gear and the driven gear are meshed and connected to form a speed change gear assembly, and the driven gear is fixedly connected to the stirring rod.

[0014] Furthermore, it also includes a support frame, which is fixed on the medicine mixing tank in an inverted U shape, and the support frame is located below the driving member. A horizontal beam is provided below the support frame, and the horizontal beam is fixedly connected to both ends below the support frame. A hole is opened on the horizontal beam, and a universal joint is provided inside the hole. The universal joint supports and connects the stirring rod to enable the stirring rod to rotate.

[0015] Furthermore, the spiral blades, the first spiral belt and the second spiral belt are all made of stainless steel.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The present invention adopts an inclined stirring rod, so that the drug flow around the stirring rod is no longer a simple radial flow, but includes a flow component along the inclined direction of the stirring rod, which changes the direction of the force of the stirring rod during the mixing process, so that the bottom end of the stirring rod is close to the inner wall of the mixing tank. The drug not only flows in the axial direction, but also forms a complex flow path in the radial direction, which improves the flow path of the drug, reduces the formation of local high-concentration areas, reduces the formation of central vortices, and makes the mixing of the drug in the tank more uniform.

[0018] The stirring paddle adopts a spiral blade and a double spiral belt design with opposite rotation directions. The spiral blade can cause the material to move along the stirring axis to form a strong axial flow. The double spiral belt design with opposite rotation directions can make the upper and lower parts of the medicine collide and cross-flow in the central area, so that the material not only moves along the stirring axis, but also diffuses in the radial direction; and the spiral line radius of the first spiral belt and the second spiral belt gradually decreases from bottom to top, so that the flow speed of the material in the axial direction gradually increases, and the material in the central area is more easily pushed to the edge of the tank body, reducing the formation of the central vortex; the setting of the guide plate on the upper surface of the spiral belt guides the flow of the material. The setting of the above-mentioned stirring paddle blades produces a three-dimensional flow of the drug, improves the flow of the drug in the axial, radial and tangential directions, balances the rotational force in the central area, reduces the formation of vortices and high shear forces in the central area, and greatly enhances the mixing effect of the material. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic structural diagram of an embodiment of the present invention.

[0020] Figure 2 For the embodiment of the present invention Figure 1 Cross-sectional view of .

[0021] Figure 3 Schematic diagram of the stirring paddle structure of an embodiment of the present invention.

[0022] Figure 4 Schematic diagram of a guide plate according to an embodiment of the present invention.

[0023] Figure 5 For the embodiment of the present invention Figure 1 Enlarged schematic diagram at point A in the middle.

[0024] Description of reference numerals:

[0025] 1. Medicine mixing tank; 2. Support frame; 3. Stirring mechanism; 301. Stirring rod; 302. Spiral blade; 303. First spiral belt; 304. Second spiral belt; 305. Support rod; 306. Guide plate; 4. Driving mechanism; 401. Driving member; 402. Driving gear; 403. Driven gear; 404. Coupling; 5. Support leg; 6. Connecting piece; 7. Universal joint; 8. Horizontal beam. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the embodiments of the present disclosure clearer, the technical solution of the embodiments of the present disclosure will be clearly and completely described below in conjunction with the drawings of the embodiments of the present disclosure. Obviously, the described embodiments are part of the embodiments of the present disclosure, not all of the embodiments. Based on the described embodiments of the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0027] Unless otherwise defined, the technical terms or scientific terms used herein should be understood by people with ordinary skills in the field to which the present disclosure belongs. "First", "second" and similar words used in the present disclosure do not indicate any order, quantity or importance, but are only used to distinguish different components. "Including" or "comprising" and similar words mean that the elements or objects appearing in front of "including" or "comprising" cover the elements or objects listed after "including" or "comprising" and their equivalents, and do not exclude other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0028] Example

[0029] A medicine mixing device of the present invention is mainly used in the field of medicine mixing, comprising a medicine mixing tank 1, such as Figure 1-Figure 5As shown, the medicine mixing tank 1 has a longitudinal axis and is centrally symmetrically arranged. For example, the medicine mixing tank 1 can be cylindrical, conical or square; three or four evenly distributed legs 5 are arranged at the bottom of the medicine mixing tank 1 for supporting the medicine mixing tank 1 so that the medicine mixing tank 1 can be placed vertically and stably on the ground. A stirring mechanism 3 is arranged inside the medicine mixing tank 1, and the stirring mechanism 3 makes a circular motion around the longitudinal axis of the medicine mixing tank 1. The stirring mechanism 3 includes a stirring rod 301, a plurality of support rods 305 and a stirring paddle, and the stirring paddle includes a spiral blade 302, a first spiral belt 303 and a second spiral belt 304.

[0030] In this embodiment, the stirring rod 301 is tilted, and the drug flow around the stirring rod 301 is no longer a simple radial flow, but includes a flow component along the tilt direction of the stirring rod 301, so that the bottom end of the stirring rod 301 is close to the inner wall of the mixing tank 1, thereby improving the circulation flow path of the material. The support rods 305 are multiple, arranged along the length direction of the stirring rod 301, and the stirring rod 301 is horizontally arranged to ensure that the first spiral belt 303 and the second spiral belt 304 are evenly supported at all positions, thereby improving the overall structural stability of the stirring paddle, and the length of the multiple support rods 305 decreases from bottom to top along the length direction of the stirring rod 301. As a preferred embodiment, the three support rods 305 are fixed on the stirring rod 301 in a decreasing length from bottom to top, supporting the first spiral belt 303 and the second spiral belt 304, so that the first spiral belt 303 and the second spiral belt 304 will not loosen or fall off during the stirring process, and the support rods 305 also have a certain stirring effect.

[0031] In this embodiment, the stirring paddle includes a spiral blade 302, a first spiral ribbon 303 and a second spiral ribbon 304. The spiral blade 302 is wound and welded on the stirring rod 301 to ensure that it will not loosen or fall off during the stirring process. The spiral blade 302 is used to guide the drug to move axially. The first spiral ribbon 303 and the second spiral ribbon 304 simultaneously promote radial and tangential mixing of the drug to improve the mixing effect. The first spiral ribbon 303 and the second spiral ribbon 304 are distributed on both sides of the stirring rod 301. The first spiral ribbon 303 and the second spiral ribbon 304 rotate in opposite directions. The spiral radius of the first spiral ribbon 303 and the second spiral ribbon 304 gradually decreases from bottom to top. During the stirring process, the material at the bottom is usually thicker or more accumulated. The spiral ribbon with a larger bottom radius can provide a stronger stirring force, effectively push and stir the bottom material, generate a strong radial and axial flow, and fully mix it. As the height increases, the drug may gradually become thinner or more dispersed. The spiral ribbon with a smaller radius can not only meet the stirring requirements, but also avoid vortexes caused by excessive stirring. The influence of flow and excessive shear force on the quality of the drug is reduced, and since the first spiral ribbon 303 and the second spiral ribbon 304 rotate in opposite directions, the first spiral ribbon 303 rotates in the clockwise direction, which will push the drug upward in the clockwise direction, and the second spiral ribbon 304 rotates in the counterclockwise direction, which will push the drug downward in the counterclockwise direction. In the central area of ​​the container, the material pushed upward by the first spiral ribbon 303 will meet the material pushed downward by the second spiral ribbon 304, thereby forming a cross-flow area of ​​mixed drugs. In the area near the container wall, due to the opposite pushing action of the two spiral ribbons, the drug will form a flow path of up and down circulation near the container wall. Therefore, the drug forms a complex three-dimensional flow in the container, with both up and down circulation and cross-flow in the central area, which greatly enhances the mixing effect of the material and enables the material to reach a uniformly mixed state in a shorter time.

[0032] The tops of the first screw belt 303 and the second screw belt 304 are respectively fixedly connected to the stirring rod 301, and the bottoms of the first screw belt 303 and the second screw belt 304 are respectively fixedly connected to the two ends of the bottom support rod 305, providing stable support for the screw belts to ensure that the screw belts will not deform or shift during the stirring process, thereby ensuring the stability and reliability of the stirring. At the same time, the collision between the support rod 305 and the drug also plays a role in assisting the stirring.

[0033] A driving mechanism 4 for driving the stirring rod 301 to perform circular motion around the longitudinal axis is provided above the stirring rod 301. The driving mechanism 4 includes a driving member 401 and a gear transmission assembly. The driving member 401 is preferably any one of a motor, an electrical driving member, a hydraulic driving member, a pneumatic driving member or an electromagnetic driving member in the prior art. The gear transmission assembly includes a driving gear 402 and a driven gear 403. The output shaft of the driving member 401 is connected to the driving gear 402 through a coupling 404, and is used to drive the driving gear 402 to rotate. The radius of the driving gear 402 is greater than the radius of the driven gear 403. The driving gear 402 is meshed and connected with the driven gear 403 to form a speed change gear assembly, which is used to make the stirring rod 301 perform circular motion around the longitudinal axis. The driven gear 403 is fixedly connected to the stirring rod 301. In the same time, the number of teeth rotated by the driving gear 402 is the same as the number of teeth rotated by the driven gear 403. Since the driving gear 402 has a large radius and a long circumference, the driven gear 403 needs to rotate more times for each rotation of the driving gear 402, thereby achieving a speed-increasing effect. A connecting member 6 is also provided below the driving gear 402 and the driven gear 403. One end of the connecting member 6 is connected to the driving gear 402, and the other end is connected to the stirring rod 301, which is used to ensure that the driving gear 402 and the driven gear 403 always maintain the correct meshing position during the rotation process to prevent the occurrence of gear disengagement.

[0034] Furthermore, the upper surfaces of the first spiral belt 303 and the second spiral belt 304 are also provided with a plurality of guide plates 306, and the plurality of guide plates 306 have an inclination angle with the upper surfaces of the plurality of first spiral belts 303 and the second spiral belt 304. The guide plates 306 are used to change the flow path of the drug on the spiral belt, so that the drug obtains a component force in another direction while being pushed by the spiral belt, so that the drug that is originally easy to form a vortex is dispersed and redirected when flowing through the guide plates 306. The inclination angle between the guide plates 306 and the upper surfaces of the plurality of first spiral belts 303 and the second spiral belt 304 is 10-45°. When the inclination angle is below 10°, the effect of the guide plates 306 on changing the flow path of the drug is small. When the inclination angle is greater than 45°, the guide plates 306 will cause the drug to undergo a drastic change in direction under the action of the guide plates 306, resulting in the formation of a turbulent vortex in a local area of ​​the drug, thereby destroying the stability of the drug. Preferably, when the inclination angle is 25 degrees, the material can be effectively guided to flow in the radial and axial directions, thereby increasing the mixing effect of the material.

[0035] Furthermore, the width of the guide plate 306 is smaller than the width of the first spiral belt 303 and the second spiral belt 304 at their respective positions, so as to ensure a smooth transition of the flow path of the drug fluid without causing sudden interruption or change to the overall flow of the drug fluid, thereby ensuring a certain stirring effect while avoiding excessive stirring of the drug fluid.

[0036] Furthermore, the stirring rod 301 is tilted, and when the bottom end of the stirring rod 301 is close to the tank wall, the fluid flow path generated by stirring is longer and more complex. The fluid rises from the bottom of the stirring rod 301 along the tank wall, and then flows to the central area of ​​the stirring rod 301, forming a large circulation flow. This circulation can make the drugs in different positions more fully mixed. In the case of mixing multiple drug components with large differences in density of each component, this overall circulation helps to overcome the stratification phenomenon caused by density differences and improve the mixing efficiency, but the larger the angle, the greater the shear force generated. The angle between the stirring rod 301 and the longitudinal axis is 5-20°. Preferably, when the angle is 15°, the flow of the material in the central area is more complex, reducing the formation of the central vortex.

[0037] Furthermore, the first spiral belt 303 and the second spiral belt 304 are symmetrically distributed on the stirring rod 301 to ensure that the entire drug fluid is evenly stirred in the mixing tank 1, avoiding the phenomenon of excessive stirring in some areas and insufficient stirring in other areas, thereby improving the uniformity of mixing.

[0038] Further, preferably, the number of the support rods 305 is 3-5, and the number of spiral turns of the first spiral ribbon 303 and the second spiral ribbon 304 is 3-5, so that the energy transfer will not be insufficient due to too few spiral ribbon turns, so that the drug fluid cannot be effectively stirred, and the energy loss will not be caused due to too many spiral ribbon turns, reducing the stirring efficiency. The connection point of the rotation diameters of two adjacent spiral ribbons is connected to the end of the support rod 305, so that the spiral ribbon and the support rod 305 form an organic whole, effectively preventing the spiral ribbon from being deformed or displaced due to the impact force of the fluid.

[0039] Furthermore, it also includes a support frame 2, which is welded on the mixing tank 1 in an inverted U shape, and the support frame 2 is located below the driving member 401. A horizontal beam 8 is arranged below the support frame 2, and the horizontal beam 8 is fixedly connected to the two ends below the support frame 2. A hole is opened on the horizontal beam 8, and a universal joint 7 is installed inside the hole. The universal joint 7 supports and connects the stirring rod 301. Preferably, the universal joint 7 is a spherical universal joint, and a hole is opened in the middle of the spherical universal joint. The stirring rod 301 passes through the hole. The spherical universal joint 7 can freely rotate in all directions at a certain angle to adapt to the circular motion of the stirring rod 301, ensuring that the stirring rod 301 is always effectively supported and rotated during the movement.

[0040] Furthermore, the spiral blade 302, the first spiral ribbon 303 and the second spiral ribbon 304 are all made of stainless steel to ensure that the blades are not corroded by the drug ingredients and can withstand various mechanical stresses generated during the stirring process.

[0041] Furthermore, a discharge port is provided at the bottom end of the inner wall of the medicine mixing tank 1, and the outer wall of the discharge port is connected to the inner wall of the box body for discharging the mixed medicine.

[0042] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug mixing device, characterized in that: The invention comprises a medicine mixing tank (1) and a stirring mechanism (3) arranged in the medicine mixing tank (1), wherein the stirring mechanism (3) performs a circular motion around the longitudinal axis of the medicine mixing tank (1), and the stirring mechanism (3) comprises: The stirring rod (301) is arranged at an angle so that the bottom end of the stirring rod (301) is close to the inner wall of the medicine mixing tank (1); A plurality of support rods (305) are arranged along the length direction of the stirring rod (301), the plurality of support rods (305) are all arranged horizontally, and the lengths of the plurality of support rods (305) decrease from bottom to top along the length direction of the stirring rod (301); The stirring paddle comprises a spiral blade (302), a first spiral ribbon (303) and a second spiral ribbon (304), wherein the spiral blade (302) is wound and fixed on the stirring rod (301), the first spiral ribbon (303) and the second spiral ribbon (304) are both distributed around the stirring rod (301), the first spiral ribbon (303) and the second spiral ribbon (304) have opposite rotation directions, the spiral line radius of the first spiral ribbon (303) and the second spiral ribbon (304) gradually decreases from bottom to top, the tops of the first spiral ribbon (303) and the second spiral ribbon (304) are respectively fixedly connected to the stirring rod (301), and the bottoms of the first spiral ribbon (303) and the second spiral ribbon (304) are respectively fixedly connected to the two ends of the bottommost support rod (305).

2. The drug mixing device according to claim 1, characterized in that: A plurality of guide plates (306) are also provided on the upper surfaces of the first spiral belt (303) and the second spiral belt (304), and the plurality of guide plates (306) are all inclined with respect to the upper surfaces of the first spiral belt (303) and the second spiral belt (304).

3. The drug mixing device according to claim 2, characterized in that: The width of the guide plate (306) is smaller than the width of the first spiral belt (303) and the second spiral belt (304) at the location.

4. The drug mixing device according to claim 1, characterized in that: The angle between the stirring rod (301) and the longitudinal axis is 5-20°.

5. The drug mixing device according to claim 3, characterized in that: The inclination angles of the guide plate (306) and the upper surfaces of the first spiral belt (303) and the second spiral belt (304) are 10-45°.

6. The drug mixing device according to claim 1, characterized in that: The first spiral ribbon (303) and the second spiral ribbon (304) are symmetrically distributed on the stirring rod (301).

7. The drug mixing device according to claim 1, characterized in that: The number of the support rods (305) is 3-5, the number of spiral turns of the first spiral belt (303) and the second spiral belt (304) is 3-5, and the connection point of the rotation diameters of two adjacent spiral belts is connected to the end of the support rod (305).

8. The drug mixing device according to claim 1, characterized in that: A driving mechanism (4) is provided above the stirring rod (301) for driving the stirring rod (301) to perform circular motion around a longitudinal axis. The driving mechanism (4) comprises a driving member (401) and a gear transmission assembly. The gear transmission assembly comprises a driving gear (402) and a driven gear (403). The output end of the driving member (401) is connected to the driving gear (402) via a coupling (404). The radius of the driving gear (402) is greater than the radius of the driven gear (403). The driving gear (402) and the driven gear (403) are meshed and connected to form a speed change gear assembly. The driven gear (403) is fixedly connected to the stirring rod (301).

9. The drug mixing device according to claim 1, characterized in that: The invention also comprises a support frame (2), wherein the support frame (2) is fixed on the medicine mixing tank (1) in an inverted U shape, and the support frame (2) is located below the driving member (401). A horizontal beam (8) is arranged below the support frame (2), and the horizontal beam (8) is fixedly connected to two ends below the support frame (2). A hole is opened on the horizontal beam (8), and a universal joint (7) is arranged inside the hole. The universal joint (7) supports and connects the stirring rod (301) so that the stirring rod (301) can rotate.

10. The drug mixing device according to claim 1, characterized in that: The spiral blade (302), the first spiral belt (303) and the second spiral belt (304) are all made of stainless steel.

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