Gel composition and oil-in-water composition

Abstract

The gel composition contains a first compound represented by polyoxyethylene phytosterol, a second compound represented by polyethylene glycol distearate, a third compound represented by polyoxyethylene alkyl ether, and a fourth compound which is a double-chain amphiphilic substance having a nitrogen atom. The first compound is 49-88 mass% with respect to the total mass of the first compound, the second compound, and the third compound. The amount of the second compound is 6-23 mass% relative to the total mass. Relative to the total mass, the third compound is 6-28 mass%. The fourth compound is contained in an amount of 0.04-0.22 parts by mass per 1 part by mass of the total mass.

Description

[0001] Related Applications

[0002] The present invention is based on the priority claim of Japanese patent application: Japanese Patent Application No. 2022-162092 (filed on October 7, 2022), and all the contents of the application are incorporated herein by reference. Technical Field

[0003] The present disclosure relates to a gel composition. In addition, the present disclosure relates to an oil-in-water composition comprising a gel composition. Background Art

[0004] Alpha gel compositions that can be used as skin external preparations and emulsifiers are known (see, for example, Patent Document 1).

[0005] The α-gel composition described in Patent Document 1 is composed of polyoxyethylene (6 mol) distearate, polyoxyethylene (10 mol) behenyl ether, and polyoxyethylene (10 mol) phytosterol.

[0006] Prior art literature

[0007] Patent Literature

[0008] Patent Document 1: Japanese Patent Application Publication No. 2017-132765 Summary of the invention

[0009] Problems to be solved by the invention

[0010] The following analysis is given from the perspective of the present disclosure.

[0011] The stratum corneum is composed of stratum corneum cells and intercellular lipids present between stratum corneum cells. Intercellular lipids have a layered structure composed of ceramide, fatty acids, cholesterol, etc. It is believed that intercellular lipids have the function of adjusting the arrangement of stratum corneum cells, protecting the skin from external stimuli, and inhibiting the evaporation of water from the skin (barrier function).

[0012] If a skin external preparation such as a cosmetic contains a component having a barrier function such as intercellular lipids, the skin external preparation can exert a strong barrier function. For example, the α gel composition described in Patent Document 1 does not contain a component related to intercellular lipids and therefore cannot exert a strong barrier function.

[0013] Therefore, a composition having a strong barrier function is required.

[0014] Means for solving problems

[0015] According to a first aspect of the present disclosure, a gel composition is provided, comprising: a first compound represented by the formula shown in the following chemical formula 1, a second compound represented by the formula shown in the following chemical formula 2, a third compound represented by the formula shown in the following chemical formula 3, and a fourth compound which is a double-chain amphiphilic substance having a nitrogen atom. The first compound is 49% to 88% by mass relative to the total mass of the first compound, the second compound, and the third compound. The second compound is 6% to 23% by mass relative to the total mass of the first compound, the second compound, and the third compound. The third compound is 6% to 28% by mass relative to the total mass of the first compound, the second compound, and the third compound. The fourth compound is 0.04% to 0.22% by mass relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound.

[0016] [Chemistry 1]

[0017]

[0018] (In the formula shown in Chemical 1, R 1 It is at least one selected from a steroid skeleton and a cholesterol skeleton. 2 is an alkylene group having 2 to 4 carbon atoms. m represents an integer of 5 to 30.

[0019] [Chemistry 2]

[0020]

[0021] (In the formula shown in Chemical 2, R 3 It is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. 4 It is an alkylene group having 2 to 4 carbon atoms. 5 is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. n represents an integer of 4 to 8.

[0022] [Chemistry 3]

[0023]

[0024] (In the formula shown in Chemical 3, R 6 It is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. 7 is an alkylene group having 2 to 4 carbon atoms. p represents an integer of 5 to 30. )

[0025] According to a second aspect of the present disclosure, there is provided an oil-in-water composition comprising the gel composition according to the first aspect and an oily component. At least a part of the oily component is contained in the gel composition.

[0026] Effects of the Invention

[0027] The gel composition of the present disclosure has a similar structure due to a component group similar to human intercellular lipids. Therefore, when the gel composition of the present disclosure is applied to the skin, a strong barrier function similar to that of human intercellular lipids can be obtained.

[0028] The gel composition of the present disclosure comprises oil droplets and can be stably dispersed in water. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 1.

[0030] Figure 2 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 2.

[0031] Figure 3 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 3.

[0032] Figure 4 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 4.

[0033] Figure 5 This is a differential calorimetry diagram in Experimental Example 4.

[0034] Figure 6 This is a polarizing microscope photograph in Experimental Example 4.

[0035] Figure 7 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 5.

[0036] Figure 8 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 6.

[0037] Fig. 9 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 7.

[0038] Fig.10 These are differential calorimetry diagrams in Test Examples 4 and 8 to 10.

[0039] Fig.11 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 11.

[0040] Fig.12 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 12.

[0041] Fig.13 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 13.

[0042] Fig.14 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 14.

[0043] Fig.15This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 15.

[0044] Fig.16 This is a differential calorimetry diagram in Test Example 15.

[0045] Fig.17 This is a polarizing microscope photograph in Experimental Example 15.

[0046] Fig.18 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 16.

[0047] Fig.19 This is a differential calorimetry diagram in Test Example 16.

[0048] Fig. 20 This is a polarizing microscope photograph in Experimental Example 16.

[0049] Fig.21 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 17.

[0050] Fig. 22 This is a differential calorimetry diagram in Test Example 17.

[0051] Fig.23 This is a polarizing microscope photograph in Experimental Example 17.

[0052] Fig.24 This is the small-angle and wide-angle X-ray scattering diagram in Experimental Example 18.

[0053] Fig.25 This is a differential calorimetry diagram in Test Example 18.

[0054] Fig.26 This is a polarizing microscope photograph in Experimental Example 18.

[0055] Fig. 27 This is a polarizing microscope photograph in Experimental Example 19.

[0056] Fig.28 for Fig. 27 A magnified portion of a polarizing microscope photograph.

[0057] Fig.29 This is a schematic diagram of the emulsified state in Test Example 19.

[0058] Fig.30 Schematic diagram of the test setup for barrier function testing.

[0059] Fig.31 The results of the barrier function test.

[0060] Fig.32 The results of the barrier function test. DETAILED DESCRIPTION

[0061] Preferred aspects of the above-mentioned viewpoints are described below.

[0062] According to a preferred embodiment of the first aspect, the first compound, the second compound, the third compound, and the fourth compound form a lamellar gel phase.

[0063] According to a preferred embodiment of the first aspect, the gel composition further comprises a fifth compound having a steroid skeleton. The fifth compound is present in an amount of 0.04 to 0.22 parts by mass based on 1 part by mass of the total mass of the first, second and third compounds.

[0064] According to a preferred embodiment of the first aspect, the first compound, the second compound, the third compound, the fourth compound, and the fifth compound form a lamellar gel phase.

[0065] According to a preferred embodiment of the first aspect, the gel composition further comprises a sixth compound comprising at least one selected from higher fatty acids having carbon numbers of 14 to 22. The sixth compound is present in an amount of 0.04 to 0.22 parts by mass based on 1 part by mass of the total mass of the first, second and third compounds.

[0066] According to a preferred embodiment of the first aspect, the first compound, the second compound, the third compound, the fourth compound, and the sixth compound form a lamellar gel phase.

[0067] According to a preferred embodiment of the first aspect, the gel composition further comprises: a fifth compound having a steroid skeleton, and a sixth compound comprising at least one selected from higher fatty acids having carbon atoms of 14 to 22. The fifth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound. The sixth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound.

[0068] According to a preferred embodiment of the first aspect, the first compound, the second compound, the third compound, the fourth compound, the fifth compound, and the sixth compound form a lamellar gel phase.

[0069] According to a preferred embodiment of the first aspect, the fifth compound is at least one selected from the group consisting of phytosterols, cholesterol, and oryzanol.

[0070] According to a preferred embodiment of the first aspect, the total mass of the first compound, the second compound, and the third compound is 29% by mass to 66% by mass relative to the mass of the gel composition.

[0071] According to a preferred embodiment of the first aspect, the fourth compound is at least one selected from the group consisting of ceramide and lecithin.

[0072] According to a preferred embodiment of the first aspect, the ceramide is at least one selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 5, and ceramide 6.

[0073] According to a preferred embodiment of the first aspect, the gel composition has a peak indicating a hexagonal structure in an X-ray scattering pattern.

[0074] According to a preferred embodiment of the first aspect, the gel composition further contains water.

[0075] According to a preferred embodiment of the second aspect, the oil-in-water composition further contains water.

[0076] According to a preferred embodiment of the second aspect, the oily component is contained in an amount of 1 to 50 parts by mass based on 1 part by mass of the gel composition.

[0077] According to a preferred embodiment of the second aspect, the oily component includes at least one selected from the group consisting of di(phytosteryl / octyldodecyl) lauroyl glutamate, polybutylene glycol, castor oil, and macadamia oil fatty acid phytosteryl ester.

[0078] In the following description, PEG is the abbreviation of polyethylene glycol, POE is the abbreviation of polyoxyethylene, POP is the abbreviation of polyoxypropylene, and the number in brackets after PEG, POE or POP represents the average added molar number of PEG, POE or POP group in the compound.

[0079] In the present disclosure, the term "effective mass" refers to an amount that can produce an effect brought about by the addition of the compound.

[0080] [First embodiment]

[0081] The gel composition involved in the first embodiment of the present disclosure is described. The gel composition of the present disclosure is a composition containing a component group that is partially or entirely different from the component group contained in the intercellular lipids present in the skin, and preferably a composition in which the component group forms a lamellar structure (lamellar gel phase) similar to the intercellular lipids. The gel composition of the present disclosure can also be referred to as "simulated intercellular lipids". In the gel composition of the present disclosure, the lamellar gel phase more preferably has an α-type structure (hexagonal crystal structure).

[0082] In the present disclosure, the so-called "lamellar gel phase" is a gel-like substance formed by an association composed of lamellar bimolecular membranes formed by the constituent components of the gel composition in the coexistence with water. In the present disclosure, the so-called "α gel" refers to a substance having a lamellar gel phase having an α-type structure (hexagonal crystal structure) in at least a part. However, in general, a gel that adopts an α-type structure ("Physical Chemistry of Cetyl Alcohol" by Shoji Fukushima, Fluglans Jahr) in an association formed by a higher aliphatic alcohol and a hydrophilic surfactant in water is called a lamellar gel.

[0083] The formation of a lamellar gel phase can be confirmed by analyzing an X-ray scattering pattern. For example, when a plurality of peaks corresponding to the long face spacing are obtained in a small angle region, it can be determined that a lamellar gel phase has been formed.

[0084] The formation of the α-type structure (hexagonal structure) can be confirmed by analyzing the X-ray scattering pattern. For example, in addition to the presence of the lamellar gel phase, in the wide-angle region (scattering vector q = 1.5 nm -1 When the presence of a peak can be confirmed even in the vicinity of α-type structure (hexagonal structure), it can be determined that an α-type structure (hexagonal structure) is formed.

[0085] The gel composition according to the first embodiment of the present disclosure comprises a first compound represented by the formula shown in the following Chemical Formula 4, a second compound represented by the formula shown in the following Chemical Formula 5, a third compound represented by the formula shown in the following Chemical Formula 6, and a fourth compound comprising at least one selected from ceramide and lecithin.

[0086] [First compound]

[0087] The first compound may be a compound represented by the formula shown in Chemical Formula 4. In the formula shown in Chemical Formula 4, R 1 is at least one selected from a steroid skeleton and a cholesterol skeleton. 1 , may be a portion other than the hydroxyl group of at least one selected from the group consisting of phytosterol, cholesterol and ergosterol. 2 is an alkylene group having 2 to 4 carbon atoms. m represents an integer of 5 or more or 10 or more. In addition, m represents an integer of 30 or less or 20 or less.

[0088] [Chemistry 4]

[0089]

[0090] Examples of the first compound include polyoxyethylene (5 mol) phytosterols (e.g., Nikkol BPS-5, manufactured by Nikko Chemichemicals Co., Ltd.), polyoxyethylene (10 mol) phytosterols (e.g., Nikkol BPS-10, manufactured by Nikko Chemichemicals Co., Ltd.), polyoxyethylene (20 mol) phytosterols (e.g., Nikkol BPS-20, manufactured by Nikko Chemichemicals Co., Ltd.), polyoxyethylene (30 mol) phytosterols (e.g., Nikkol BPS-30, manufactured by Nikko Chemichemicals Co., Ltd.), and polyoxyethylene (10 mol) cholesterol (e.g., Emalex CS-10, manufactured by Nippon Emal Dioxide Co., Ltd.).

[0091] The first compound is preferably 49% by mass or more, more preferably 55% by mass or more, more preferably 60% by mass or more, and further preferably 62% by mass or more relative to the total mass of the first compound, the second compound, and the third compound. The first compound is preferably 88% by mass or less, more preferably 82% by mass or less, more preferably 76% by mass or less, and further preferably 73% by mass or less relative to the total mass of the first compound, the second compound, and the third compound.

[0092] The first compound may be, for example, 2% by mass or more, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, or 30% by mass or more relative to the mass of the gel composition. The first compound may be, for example, 50% by mass or less, 45% by mass or less, 35% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less relative to the mass of the gel composition.

[0093] [Second compound]

[0094] The second compound may be a compound represented by the formula shown in Chemical 5. In the formula shown in Chemical 5, R 3 It is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. 4 It is an alkylene group having 2 to 4 carbon atoms. 5 It is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. n represents an integer of 4 to 8.

[0095] [Chemistry 5]

[0096]

[0097] Examples of the second compound include polyoxyethylene (4 mol) distearate (e.g., Emalex 200DIS, manufactured by Japan Emaldion Co., Ltd.), polyoxyethylene (6 mol) distearate (e.g., Emalex 300DIS, manufactured by Japan Emaldion Co., Ltd.), polyoxyethylene (8 mol) distearate (e.g., Emalex 400DIS, manufactured by Japan Emaldion Co., Ltd.), steareth-4 stearate (e.g., Emalex SWS-4, manufactured by Japan Emaldion Co., Ltd.), steareth-6 stearate (e.g., Emalex SWS-6, manufactured by Japan Emaldion Co., Ltd.), and polyoxyethylene (8 mol) dibehenyl ether. The bonding form of the polyoxyethylene chain and the alkyl group may be an ester or an ether, and may include both.

[0098] The second compound is preferably 6% by mass or more, more preferably 8% by mass or more, more preferably 10% by mass or more, and further preferably 11% by mass or more relative to the total mass of the first, second and third compounds. The second compound is preferably 23% by mass or less, more preferably 21% by mass or less, more preferably 19% by mass or less, and further preferably 18% by mass or less relative to the total mass of the first, second and third compounds.

[0099] The amount of the second compound relative to the mass of the gel composition may be, for example, 0.1 mass % or more, 0.5 mass % or more, 1 mass % or more, 2 mass % or more, 3 mass % or more, or 4 mass % or more. The amount of the second compound relative to the mass of the gel composition may be, for example, 20 mass % or less, 16 mass % or less, 12 mass % or less, 10 mass % or less, 8 mass % or less, or 6 mass % or less.

[0100] [Third Compound]

[0101] The third compound may be a compound represented by the formula shown in Chemical 6. In the formula shown in Chemical 6, R 6 It is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms. 7 is an alkylene group having 2 to 4 carbon atoms. p represents an integer of 5 or more or 10 or more. In addition, p represents an integer of 30 or less or 20 or less.

[0102] [Chemistry 6]

[0103]

[0104] Examples of the third compound include polyoxyethylene (10 mol) behenyl ether (e.g., Nikkol BB-10, manufactured by Nikko Chemikals Co., Ltd.), polyoxyethylene (20 mol) behenyl ether (e.g., Nikkol BB-20, manufactured by Nikko Chemikals Co., Ltd.), polyoxyethylene (30 mol) behenyl ether (e.g., Nikkol BB30, manufactured by Nikko Chemikals Co., Ltd.), polyoxyethylene (7 mol) cetyl ether (e.g., Emalex 107, manufactured by Nippon Emaldion Co., Ltd.), and polyoxyethylene (10 mol) stearyl ether (e.g., Emalex 610, manufactured by Nippon Emaldion Co., Ltd.).

[0105] The third compound is preferably 6% by mass or more, more preferably 8% by mass or more, more preferably 10% by mass or more, and further preferably 11% by mass or more relative to the total mass of the first, second and third compounds. The third compound is preferably 28% by mass or less, more preferably 26% by mass or less, more preferably 24% by mass or less, and further preferably 23% by mass or less relative to the total mass of the first, second and third compounds.

[0106] The third compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, or 4% by mass or more relative to the mass of the gel composition. The third compound may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less relative to the mass of the gel composition.

[0107] The total mass of the first compound, the second compound, and the third compound is preferably 29% by mass or more, more preferably 33% by mass or more, more preferably 37% by mass or more, and further preferably 41% by mass or more, relative to the mass of the gel composition. The total mass of the first compound, the second compound, and the third compound is preferably 66% by mass or less, more preferably 61% by mass or less, more preferably 59% by mass or less, and further preferably 54% by mass or less, relative to the mass of the gel composition.

[0108] [Fourth Compound]

[0109] The fourth compound is a double-chain amphiphilic substance having a nitrogen atom. The so-called "double-chain" means that the amphiphilic substance has two carbon chains, preferably hydrocarbon chains with 5 to 24 carbon atoms. The hydrocarbon chain can be saturated or unsaturated. The hydrocarbon chain is preferably a straight chain. The amphiphilic substance is a substance having a hydrophilic part and a hydrophobic part. The fourth compound can contain, for example, at least one selected from ceramide and lecithin.

[0110] Ceramide may be natural ceramide or synthetic ceramide. Synthetic ceramide may have the same structure as natural ceramide or may have a similar structure. Ceramide is preferably capable of forming a lamellar gel structure with at least the first compound, the second compound and the third compound. Ceramide is preferably human ceramide. Ceramide is more preferably at least one selected from ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 5 and ceramide 6.

[0111] The lecithin may be, for example, at least one selected from soybean lecithin, egg yolk lecithin, and hydrogenated lecithin. The lecithin may be phosphatidylcholine.

[0112] The fourth compound is preferably 0.04 parts by mass or more, more preferably 0.06 parts by mass or more, and further preferably 0.08 parts by mass or more, relative to 1 part by mass of the total amount (total mass) of the first compound, the second compound, and the third compound in the gel composition. The fourth compound is preferably 0.22 parts by mass or less, more preferably 0.20 parts by mass or less, more preferably 0.17 parts by mass or less, and further preferably 0.14 parts by mass or less, relative to 1 part by mass of the total amount of the first compound, the second compound, and the third compound in the gel composition.

[0113] The fourth compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, or 4% by mass or more relative to the mass of the gel composition. The fourth compound may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less relative to the mass of the gel composition.

[0114] When the gel composition does not contain the fifth compound and the sixth compound described below, it is preferred that the first compound, the second compound, the third compound, and the fourth compound form a lamellar gel phase in the gel composition.

[0115] The gel composition may further contain water. The amount of water relative to the mass of the gel composition may be, for example, 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, or 35% by mass or more. The amount of water relative to the mass of the gel composition may be, for example, 60% by mass or less, 55% by mass or less, 50% by mass or less, 45% by mass or less, 40% by mass or less, or 35% by mass or less.

[0116] According to the gel composition according to the first embodiment, when the gel composition is applied to the skin, the skin barrier function can be exerted, for example, the evaporation of water from the inside of the skin can be suppressed (sealed).

[0117] The gel composition according to the first embodiment has a high barrier function.

[0118] The gel composition according to the first embodiment contains oil droplets and can be stably dispersed in water.

[0119] [Second embodiment]

[0120] The gel composition according to the second embodiment of the present disclosure will be described. The gel composition according to the second embodiment of the present disclosure further includes a fifth compound in addition to the components in the gel composition according to the first embodiment.

[0121] [Fifth Compound]

[0122] The fifth compound is a compound having a steroid skeleton (cyclopentanepolyhydrophenanthrene ring). The fifth compound may be, for example, at least one selected from the group consisting of phytosterols, cholesterol, and oryzanol (γ-oryzanol).

[0123] When the gel composition does not contain the sixth compound, it is preferred that the first compound, the second compound, the third compound, the fourth compound, and the fifth compound form a lamellar gel phase in the gel composition.

[0124] The fifth compound is preferably 0.04 parts by mass or more, more preferably 0.06 parts by mass or more, and further preferably 0.08 parts by mass or more, relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound in the gel composition. The fifth compound is preferably 0.22 parts by mass or less, more preferably 0.20 parts by mass or less, more preferably 0.17 parts by mass or less, and further preferably 0.14 parts by mass or less, relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound in the gel composition.

[0125] The fifth compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, or 4% by mass or more relative to the mass of the gel composition. The fifth compound may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less relative to the mass of the gel composition.

[0126] Regarding components other than the fifth compound, the description in the first embodiment is cited.

[0127] The gel composition according to the second embodiment can obtain the same effects as those of the first embodiment. According to the second embodiment, the stability of the gel composition can be improved compared to the first embodiment.

[0128] [Third embodiment]

[0129] The gel composition according to the third embodiment of the present disclosure will be described. The gel composition according to the third embodiment of the present disclosure further includes a sixth compound in addition to the components in the gel composition according to the first embodiment.

[0130] [Sixth Compound]

[0131] The sixth compound may be at least one selected from higher fatty acids having carbon atoms of 14 to 22. Examples of the sixth compound include stearic acid.

[0132] When the gel composition does not contain the fifth compound, it is preferred that the first compound, the second compound, the third compound, the fourth compound, and the sixth compound form a lamellar gel phase in the gel composition.

[0133] The sixth compound is preferably 0.04 parts by mass or more, more preferably 0.06 parts by mass or more, and further preferably 0.08 parts by mass or more, relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound in the gel composition. The sixth compound is preferably 0.22 parts by mass or less, more preferably 0.20 parts by mass or less, more preferably 0.17 parts by mass or less, and further preferably 0.14 parts by mass or less, relative to 1 part by mass of the total mass of the first compound, the second compound, and the third compound in the gel composition.

[0134] The sixth compound may be, for example, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 2% by mass or more, 3% by mass or more, or 4% by mass or more relative to the mass of the gel composition. The sixth compound may be, for example, 20% by mass or less, 16% by mass or less, 12% by mass or less, 10% by mass or less, 8% by mass or less, or 6% by mass or less relative to the mass of the gel composition.

[0135] Regarding components other than the sixth compound, the description in the first embodiment is cited.

[0136] The gel composition according to the third embodiment can obtain the same effects as those of the first embodiment. According to the third embodiment, the stability of the gel composition can be improved compared to the first embodiment.

[0137] [Fourth embodiment]

[0138] The gel composition according to the fourth embodiment of the present disclosure will be described. The gel composition according to the fourth embodiment of the present disclosure further includes a fifth compound and a sixth compound in addition to the components in the gel composition according to the first embodiment.

[0139] Regarding the fifth compound, the description of the second embodiment is cited. Regarding the sixth compound, the description of the third embodiment is cited. Regarding components other than the fifth compound and the sixth compound, the description of the first embodiment is cited.

[0140] It is preferred that the first compound, the second compound, the third compound, the fourth compound, the fifth compound and the sixth compound form a lamellar gel phase in the gel composition.

[0141] The gel composition according to the fourth embodiment can obtain the same effects as those of the first embodiment. According to the fourth embodiment, the stability of the gel composition can be improved compared with the first to third embodiments.

[0142] [Fifth embodiment]

[0143] The oil-in-water composition according to the fifth embodiment of the present disclosure is described. The oil-in-water composition according to the fifth embodiment of the present disclosure comprises at least one of the gel compositions according to the first to fourth embodiments and an oily component. The oily component in the fifth embodiment does not contain the first to sixth compounds.

[0144] At least a part of the oily component is contained in the gel composition. The oily component exists as oil droplets and can be in an emulsified state by the gel composition.

[0145] The average particle size of the oily component may be, for example, 0.5 μm or more. The average particle size of the oily component may be, for example, 10 μm or less.

[0146] The oily component is not particularly limited, and may be appropriately blended with, for example, liquid oils, solid oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, etc. The oily component is preferably liquid at 25° C. under atmospheric pressure.

[0147] The oily component preferably contains a component that softens the stratum corneum (stratum corneum softening component). Examples of the stratum corneum softening component include at least one selected from di(phytosteryl / octyldodecyl) lauroyl glutamate, polybutylene glycol, castor oil, and macadamia nut oil fatty acid phytosteryl ester.

[0148] Examples of the liquid oil include avocado oil, camellia oil, turtle oil, macadamia oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, peach kernel oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, ginkgo oil, rice bran oil, tung oil (sinagi oil), Japanese tung oil, jojoba oil, germ oil, and triglycerol.

[0149] Examples of the solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, wood wax kernel oil, hardened oil, beef stub fat, wood wax, and hardened castor oil.

[0150] Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, insect wax, spermaceti wax, montan wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl ester, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol ester, and POE hydrogenated lanolin alcohol ether.

[0151] Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, and microcrystalline wax.

[0152] Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall oil acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0153] As higher alcohols, for example, straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, a mixture of cetostearyl alcohol and the like); branched-chain alcohols (e.g., monostearyl glyceryl ether (baty alcohol), 2-decyltetradecynyl alcohol, lanolin alcohol, cholesterol, phytosterols, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) and the like can be used.

[0154] Examples of the synthetic ester oil include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, acetylated lanolin, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, di-2-heptylundecanoic acid glyceryl, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate Esters, tri-2-ethylhexanoin, tricaprylin, triisopalmitin, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristin, tri-2-heptylundecanoic acid glyceryl, castor oil fatty acid methyl ester, oleyl oleate, acetylated glyceryl, 2-heptylundecyl palmitate, diisobutyl adipate, 2-octyldodecyl N-lauroyl-L-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, etc.

[0155] Examples of the silicone oil include dimethylpolysiloxane, methyl hydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicic acid, silicone RTV rubber, and silicone compounds such as cyclic pentasiloxane.

[0156] The stratum corneum softening component preferably contains 0.5 mass % or more relative to the mass of the oil-in-water composition. The stratum corneum softening component may be, for example, 1 mass % or more, 2 mass % or more, or 3 mass % or more relative to the mass of the oil-in-water composition. The stratum corneum softening component may be, for example, 15 mass % or less, 12 mass % or less, 10 mass % or less, 8 mass % or less, or 5 mass % or less relative to the mass of the oil-in-water composition.

[0157] The oily component may include an oily component with a molecular weight of 400 or less. By including an oily component with a molecular weight of 400 or less, the cleaning property for oily objects to be cleaned, such as makeup, can be improved. As the oily component with a molecular weight of 400 or less, for example, at least one selected from tripropylene glycol dineopentanoate, isodecane, isononyl isononanoate, cetyl ethylhexanoate, ethyl isostearate, isobutyl isostearate, isodecyl neopentanoate, octyldodecyl neopentanoate, myristyl neopentanoate, and isostearyl neopentanoate can be cited.

[0158] The oily component having a molecular weight of 400 or less may account for 50 mass % or more, 60 mass % or more, 70 mass % or more, 80 mass % or more, 90 mass % or more, or 100 mass % based on the mass of the oily component.

[0159] The oily component is preferably 1 part by mass or more relative to 1 part by mass of the total mass of the first compound, the second compound, the third compound, the fourth compound, the fifth compound and the sixth compound (i.e., the mass of the gel composition excluding water). For example, the oily component may be 5 parts by mass or more, 10 parts by mass or more, 15 parts by mass or more, 20 parts by mass or more, 25 parts by mass or more, 30 parts by mass or more, 35 parts by mass or more, or 40 parts by mass or more relative to 1 part by mass of the total mass of the first to sixth compounds. If the oily component is less than 1 part by mass, the effect of the oily component cannot be fully exerted. The oily component is preferably 50 parts by mass or less relative to 1 part by mass of the total mass of the first to sixth compounds. For example, the oily component may be 45 parts by mass or less, 40 parts by mass or less, 35 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, 20 parts by mass or less, 15 parts by mass or less, or 10 parts by mass or less relative to 1 part by mass of the total mass of the first to sixth compounds. If the oily component exceeds 50 parts by mass, inclusion in the gel composition becomes difficult.

[0160] The content of the oily component may be, for example, 1% or more or 5% or more by mass relative to the mass of the oil-in-water composition, or 50% or less or 25% or less by mass relative to the mass of the oil-in-water composition.

[0161] The oil-in-water composition of the present disclosure may further contain water other than the water contained in the gel composition. The content of water may be 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 35% by mass or more, or 40% by mass or more relative to the mass of the composition. The content of water may be 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less relative to the mass of the composition. The water content mentioned here includes not only the water in the aqueous phase but also the water contained in the gel composition.

[0162] The oil-in-water composition of the present disclosure may further include powder. The powder may also be a powder whose particle surface is hydrophobic. The hydrophobic powder may also include a powder whose particle surface has been hydrophobized. It is believed that at least a portion of the hydrophobic powder is encapsulated in the oil droplet particles (oil phase) in the oil-in-water composition.

[0163] A portion of the hydrophobic powder may be present in the aqueous phase. It is believed that the gel composition of the present disclosure adheres to at least a portion of the surface of the hydrophobic powder in the aqueous phase. Therefore, the dispersibility of the hydrophobic powder is improved even in the aqueous phase.

[0164] The method for the hydrophobization treatment of powder can include, for example, using silicone resins such as methyl hydrogenated polysiloxane, dimethylpolysiloxane, dextrin fatty acid esters, higher fatty acids, higher alcohols, fatty acid esters, metal soaps, alkyl phosphate ethers, fluorinated compounds or squalane, hydrocarbons such as paraffin, by using a wet method, a vapor phase method, a mechanochemical method, etc. of a solvent to carry out hydrophobization treatment. Hydrophobic powder can be, for example, a powder of a metal oxide that has been hydrophobized. Metal oxide can be, for example, a powder that works as an ultraviolet scattering agent. As metal oxide, for example, zinc oxide, titanium oxide, iron oxide, cerium oxide, etc. can be mentioned.

[0165] The hydrophobic powder may have a primary particle having an average particle size of 10 nm or more. The hydrophobic powder may have a primary particle having an average particle size of, for example, 500 nm or less, 200 nm or less, 100 nm or less, 50 nm or less, or 40 nm or less. The average particle size of the primary particles of the hydrophobic powder may be determined using a dynamic light scattering method.

[0166] When there are multiple types of hydrophobic powders, the average particle size of the primary particles of the hydrophobic powder can be calculated by considering the abundance ratio of each powder, that is, it can be the sum of the mass ratio of each powder to the total amount of the hydrophobic powder multiplied by the particle size (catalog value) of each powder.

[0167] The powder is not particularly limited as long as it is a substance that can be generally used in cosmetic applications. As the powder, for example, inorganic powder (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, lithium mica, calcined mica, calcined talc, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silicon dioxide, zeolite, glass, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powder (for example, polyamide Amine resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone resin powder, silk powder, wool powder, urethane powder, etc.); inorganic white pigment (for example, titanium dioxide, zinc oxide, etc.); inorganic red pigment (for example, iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigment (γ-iron oxide, etc.), inorganic yellow pigment (yellow iron oxide, loess, etc.), inorganic black pigment (black iron oxide, carbon black, low-cost oxide titanium, etc.), inorganic purple pigments (e.g., manganese violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, navy, etc.); pearlescent pigments (e.g., titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lakes (e.g., Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 2 28, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, and Blue 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.); wax powders (e.g., carnauba wax powder, etc.); starch powders (e.g., corn starch powder, rice starch powder, etc.), etc.

[0168] The hydrophobic powder is preferably 0.5% by mass or more relative to the mass of the oil-in-water composition. The hydrophobic powder, for example, can be 1% by mass or more, 3% by mass or more, 5% by mass or more, 8% by mass or more, 10% by mass or more, 15% by mass or more, or 20% by mass or more relative to the mass of the oil-in-water composition. If the hydrophobic powder is less than 0.5% by mass, the effect brought by the hydrophobic powder cannot be obtained. The hydrophobic powder is preferably 30% by mass or less relative to the mass of the oil-in-water composition. The hydrophobic powder, for example, can be 25% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, 8% by mass or less, 5% by mass or less, or 3% by mass or less relative to the mass of the oil-in-water composition. If the hydrophobic powder exceeds 30% by mass, the hydrophobic powder cannot be completely enclosed in the oil phase.

[0169] According to the oil-in-water composition of the present disclosure, the oily component can be stably dispersed. In addition, when the oil-in-water composition of the present disclosure is applied to the skin, the high barrier function of the gel composition of the present disclosure can be exerted.

[0170] In the gel composition and oil-in-water composition of the present disclosure, sometimes the phase structure and the like cannot be directly specified by the composition, or it is almost impractical. In such a case, the gel composition and oil-in-water composition of the present disclosure should be allowed to be specified by its production method.

[0171] [Manufacturing method]

[0172] The method for producing the gel composition according to the first to fourth embodiments of the present disclosure is described. The method for producing the gel composition may include, for example, a step of heating and melting the above-mentioned first to sixth compounds (at least the first to fourth compounds), and a step of mixing the molten mixture with water and stirring. The first to sixth compounds may be melted at, for example, 70°C to 110°C. The water is preferably heated to the same degree as the mixture (for example, 70°C to 80°C; for example, ±15°C). The lamellar gel phase can be obtained by cooling after mixing with water.

[0173] The method for producing an oil-in-water composition according to the fifth embodiment of the present disclosure is described. As a first embodiment, the method for producing an oil-in-water composition may include, for example, a step of emulsifying an oily component with a gel composition (lamellar gel phase), and a step of adding an aqueous component after emulsification. The step of emulsifying the oily component may include, for example, a step of preparing a solution in which the first to sixth compounds (at least the first to fourth compounds) are dissolved in a polyol (e.g., dipropylene glycol, 1,3-butylene glycol), and a step of emulsifying while adding the oily component to the solution. For example, the oil-in-water composition of the present disclosure may be produced using a non-aqueous emulsification method (D-phase emulsification method). By using a non-aqueous emulsification method, the emulsified particles can be made finer. In addition, the lamellar gel phase can be adsorbed on the oil-water interface.

[0174] The oil-in-water composition of the present invention may contain other ingredients as needed, for example, amphoteric surfactants, hydrophilic nonionic surfactants, lipophilic nonionic surfactants, water-soluble polymers, thickeners, moisturizers, film-forming agents, oil-soluble ultraviolet absorbers, water-soluble ultraviolet absorbers, metal ion blocking agents, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, etc., within the range that does not impair the effects of the present invention.

[0175] Examples of the amphoteric surfactant include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazolinium sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethoxy di-sodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecanyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine, sulfobetaine, etc.); and the like.

[0176] Examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters (e.g., POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-sorbitan fatty acid esters (e.g., POE-sorbitan monolaurate, POE-sorbitan monooleate, POE-sorbitan pentaoleate, POE-sorbitan monostearate, etc.); POE-glycerol fatty acid esters (e.g., POE-sorbitan monolaurate, POE-sorbitan monooleate, POE-sorbitan pentaoleate, POE-sorbitan monostearate, etc.); POE-esters (e.g., POE-glyceryl monostearate, POE-glyceryl monoisostearate, POE-glyceryl triisostearate, POE-monooleate, etc.); POE-fatty acid esters (e.g., POE-distearate, POE-monodioleate, ethylene glycol distearate, etc.); POE-alkyl ethers (e.g., POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (e.g., プルPOE / POP-alkyl ethers (e.g., POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerol ether, etc.); tetra-POE / tetra-POP-ethylenediamine condensates (e.g., Tetronic, etc.); POE-castor oil hardened castor oil derivatives (e.g., POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate , POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate diester, POE-hardened castor oil maleic acid, etc.); POE-beeswax / lanolin derivatives (for example, POE-sorbitol beeswax, etc.); alkanolamides (for example, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid esters; POE-alkylamines; POE-fatty acid amides; sucrose fatty acid esters; alkyl ethoxydimethylamine oxide; trioleyl phosphoric acid, etc.

[0177] Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan penta-2-ethylhexyl diglycerol sorbitan ester, tetra-2-ethylhexyl diglycerol sorbitan ester, etc.); glycerol polyglycerol fatty acid esters (e.g., cottonseed oil fatty acid glyceryl, monoerucyl glyceryl, sesquioleyl glyceryl, monostearic glyceryl, α,α'-oleyl pyroglutamic acid glyceryl, monostearic glyceryl malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); hardened castor oil derivatives; glycerol alkyl ethers, etc.

[0178] As natural water-soluble polymers, for example, plant polymers (for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seeds (quince), alginate (brown algae extract), starch (rice, corn, potato, wheat), glycyrrhizic acid); microbial polymers (for example, xanthan gum, dextran, succinoglycan, pullulan, etc.); animal polymers (for example, collagen, casein, albumin, gelatin, etc.), etc. can be mentioned.

[0179] As the semi-synthetic water-soluble polymer, for example, starch-based polymers (for example, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); alginic acid-based polymers (for example, sodium alginate, propylene glycol alginate, etc.), etc.

[0180] Examples of synthetic water-soluble polymers include vinyl polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymers, etc.); polyoxyethylene polymers (e.g., polyoxyethylene-polyoxypropylene copolymers of polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic polymers (e.g., sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethylene imine; cationic polymers, etc.

[0181] Examples of the thickener include gum arabic, carrageenan, karaya gum, tragacanth gum, carob bean gum, quince seeds (quinces), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinyl pyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tatar seed gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, magnesium aluminum silicate (ビーガム), LAPONITE, silicic anhydride, taurate-based synthetic polymers, and acrylate-based synthetic polymers.

[0182] Examples of the moisturizing agent include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucin sulfate, caloninic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile acid salts, dl-pyrrolidonecarboxylate, oxyalkylene derivatives, short-chain soluble collagen, diglycerol (EO) PO adducts, smilax glabra extract, Achillea millefolium extract, and sweet clover extract.

[0183] Examples of the coating agent include anionic coating agents (e.g., (meth)acrylic acid / (meth)acrylate copolymers, methyl vinyl ether / maleic anhydride polymers, etc.), cationic coating agents (e.g., cationized cellulose, dimethyldiallyl ammonium chloride polymers, dimethyldiallyl ammonium chloride / acrylamide copolymers, etc.), and nonionic coating agents (e.g., polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetate, polyacrylate copolymers, (meth)acrylamide, polymer silicone, silicone resins, trimethylsiloxysilicic acid, etc.).

[0184] Examples of the oil-soluble ultraviolet absorber include benzoic acid-based ultraviolet absorbers (e.g., para-aminobenzoic acid (hereinafter, abbreviated as PABA), PABA monoglyceride, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl benzoic acid hexyl ester, etc.); anthranilic acid-based ultraviolet absorbers (e.g., high salicylic acid-based ultraviolet light absorbers (e.g., ethylhexyl salicylate, amyl salicylate, salicylic acid Base ester, high salicylic acid esters, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropyl phenyl salicylate, homosalate, etc.); cinnamic acid-based ultraviolet absorbers (for example, octyl methoxycinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isopentyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate, methyl 2-(2-(4-(2-ethylhexyl)-2-(2-methyl-2-thiazolyl)-1,2-dimethoxycinnamate); 2-(2-(2-(2-hydroxy-5-methyl-2-thiazolyl)-1,2-dimethoxycinnamate); 2-(2-(2-hydroxy-5-methyl-2-thiazolyl)-1,2-dimethoxycinnamate; 2-(2-(2-hydroxy-5-tert-octylphenyl)-1,2-dimethoxycinnamate); ... ; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzyl azide; anisyl methane; 4-methoxy-4'-tert-butyl dibenzoyl methane; 5-(3,3-dimethyl-2-nitro-norbornyl)-3-pentane-2-one, dimorpholinopyridazinone; 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene); 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-(1,3,5)-triazine, benzophenone-based ultraviolet absorbers (e.g., 2,4 benzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4-methylbenzophenone, 2-hydroxy-4-methoxy-benzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.

[0185] Examples of the water-soluble ultraviolet absorber include benzophenone ultraviolet absorbers (e.g., 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), benzylidene camphor ultraviolet absorbers (benzylidene camphor sulfonic acid, terephthalylidene dicamphor sulfonic acid, etc.), and phenylbenzimidazole ultraviolet absorbers (phenylbenzimidazole sulfonic acid, etc.).

[0186] Examples of the metal ion blocking agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium ethylenediaminetetraacetate, trisodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0187] Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.), basic amino acids (e.g., hydroxylysine, etc.), etc. In addition, examples of amino acid derivatives include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0188] Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0189] Examples of the polymer emulsion include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin liquid, polyacrylic acid alkyl ester emulsion, polyvinyl acetate resin emulsion, and natural rubber latex.

[0190] Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.

[0191] Examples of the vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

[0192] Examples of the antioxidant include tocopherols, butylated hydroxytoluene, butylated hydroxyanisole, and gallic acid esters.

[0193] Examples of the antioxidant aid include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

[0194] As other ingredients that can be mixed, for example, preservatives (ethyl paraben, butyl paraben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (for example, glycyrrhizic acid derivatives, glycyrrhizic acid derivatives, salicylic acid derivatives, cyperiol, zinc oxide, allantoin, etc.); whitening agents (for example, placenta extract, saxifrage extract, arbutin, etc.); various extracts (for example, phellodendron, coptis root, lithospermum, peony, Japanese swertia, birch, sage, loquat, carrot, aloe, mallow, iris, grape, coix seed, loofah, lily, saffron, ligusticum chuanxiong, ginger, small coptis root); forsythia, red onion flower, garlic, pepper, tangerine peel, angelica, seaweed, etc.), activators (for example, royal jelly, photosensitizers, cholesterol derivatives, etc.); blood circulation promoters (for example, nonanoic acid vanillamide, benzyl nicotinate, nicotinic acid β-butoxyethyl ester, capsaicin, ginger ketone, blister beetle tincture, ichthyol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cycloamycin, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); anti-seborrheic agents (for example, sulfur, dimethylthianthrene, etc.); anti-inflammatory agents (for example, tranexamic acid, thiotaurine, hypotaurine, etc.), etc.

[0195] Example

[0196] The following examples illustrate the gel composition and oil-in-water composition of the present disclosure. However, the gel composition and oil-in-water composition of the present disclosure are not limited to the following examples. The unit of the content rate of each component shown in each table is mass %.

[0197] [Test Examples 1 to 4]

[0198] The components shown in Table 1 except ion exchange water were melted at 100°C to prepare a uniform mixture. After adding ion exchange water at 70-80°C to the mixture and mixing, it was cooled. Next, degassing was performed by centrifugal separation to prepare a gel. The gel of each test example was subjected to small-angle and wide-angle X-ray scattering measurement and differential scanning calorimetry (DSC measurement). The gel composition of Test Example 4 was observed using a polarizing microscope. Figure 1 to Figure 4 The small-angle and wide-angle X-ray scattering patterns of the compositions of Test Examples 1 to 4 are shown in FIG. Figure 5 The differential scanning calorimetry diagram of the composition of Test Example 4 is shown in FIG. Figure 6 Polarizing microscope images are shown in .

[0199] [Small-angle and wide-angle X-ray scattering measurement]

[0200] Small-angle and wide-angle X-ray scattering of the composition of each Test Example was measured at 20°C using a SWAXS measuring apparatus SAXSees mc2 (manufactured by Antoon Pal GmbH, Graz, Austria).

[0201] [Differential Scanning Calorimetry]

[0202] A differential scanning calorimeter DSC1 (METTLER TOLEDO, Lake Griffin, Switzerland) was used. About 7 mg of the composition of each test example was put into an aluminum pan and the temperature was raised to 25 to 115° C. at 2° C. per minute for measurement.

[0203] [Image taken with a polarizing microscope]

[0204] The polarizing microscope image was captured using a polarizing microscope BX53 manufactured by Orionpass Corporation at a magnification of 400 times and using crossed Nicol prisms for polarizing plates.

[0205] In any of the X-ray graphs of Test Examples 1 to 4, a peak corresponding to the long face spacing of the lamellar gel is present on the small angle side, indicating that the compositions of Test Examples 1 to 4 have a lamellar structure. In addition, the scattering vector q = 1.5 nm -1 The peaks near α-type structure are shown, indicating that there is a hexagonal crystal lattice of α-type structure, and the regularity of the sublattice plane becomes higher. Therefore, it is confirmed that the obtained composition is α-gel. By having an α-gel structure, the precipitation of hydrated crystals can be suppressed, and a high barrier function can be exerted.

[0206] Based on the similarity between the constituent components of human intercellular lipids and those of Test Examples 1 to 4, it is considered that the compositions of Test Examples 1 to 4 have components and structures similar to those of human intercellular lipids and constitute simulated intercellular lipids.

[0207] In the composition of Test Example 4, there was no peak derived from ceramide 3. From this, it is considered that the stability of the gel composition can be improved by adding a sterol compound and a higher fatty acid.

[0208] according to Figure 5 The differential scanning calorimetry chart shown shows that the composition of at least Test Example 4 has a eutectic point due to the presence of an endothermic peak. The presence of a eutectic point can suppress the precipitation of a part of crystals.

[0209] pass Figure 6 The polarizing microscopy images shown also confirm the formation of lamellar gels.

[0210] Table 1

[0211]

[0212] [Test Examples 5 to 7]

[0213] In Test Examples 1 to 4, the types of ceramide were changed, and the gel compositions were prepared in the same manner as in Test Examples 1 to 4. The compositions are shown in Table 2. Figures 7 to 9The small-angle and wide-angle X-ray scattering patterns of the compositions of Test Examples 5 to 7 are shown in FIG.

[0214] The presence of a lamellar gel phase having a hexagonal crystal structure was confirmed in all compositions. Therefore, it is considered that any type of ceramide can produce a gel composition.

[0215] Table 2

[0216]

[0217] [Test Examples 8 to 14]

[0218] The amount of each component blended in Test Examples 1 to 4 was changed, and the gel compositions were prepared in the same manner as in Test Examples 1 to 4. The compositions are shown in Tables 3 and 4. Fig.10 The differential scanning calorimetry diagrams of Test Examples 4 and 8 to 10 are shown in FIG. Figure 11 to Figure 14 The small-angle and wide-angle X-ray scattering patterns of the compositions of Test Examples 11 to 14 are shown in FIG.

[0219] In the compositions of Test Examples 8 to 10, unlike the composition of Test Example 4, a peak due to the eutectic point was confirmed at around 80° C. The presence of the eutectic point can suppress the precipitation of a part of crystals.

[0220] In the compositions of Test Examples 11 to 14, the presence of a lamellar gel phase having a hexagonal crystal structure was also confirmed.

[0221] Table 3

[0222]

[0223] Table 4

[0224]

[0225] [Test Examples 15 to 18]

[0226] The ceramide and phytosterol in Test Examples 1 to 4 were replaced with other compounds, and gel compositions were prepared in the same manner as in Test Examples 1 to 4. The compositions are shown in Table 5. Fig.15 , Fig.18 , Fig.21 and Fig.24 The small-angle and wide-angle X-ray scattering patterns of the compositions of Test Examples 15 to 18 are shown in FIG. Fig.16 , Fig.19 , Fig. 22 and Fig.25 The differential scanning calorimetry diagrams of the compositions of Test Examples 15 to 18 are shown in FIG. Fig.17 , Fig. 20 , Fig.23 and Fig.26Polarizing microscope photographs of the compositions of Test Examples 15 to 18 are shown in FIG.

[0227] It was confirmed that a gel composition can be prepared even if lecithin is used instead of ceramide. In addition, it was confirmed that a gel composition can be prepared even if cholesterol and oryzanol are used instead of phytosterol. In addition, in Test Examples 15 to 18, the same operation as the above Test Examples was performed to confirm that there was a eutectic point.

[0228] Table 5

[0229]

[0230] [Test Example 19]

[0231] An oil-in-water composition is prepared using the gel composition disclosed in the present invention. First, after PEG-10 phytosterol, PEG-6 distearate, beheneth-10, ceramide 3, phytosterol and stearic acid are mixed at 80°C, a portion of 80°C ion exchange water is added to prepare a gel composition. Next, an oily component at 80°C is added to the gel composition and mixed. Then, other components are added and mixed. A polarizing microscope photograph is taken of the resulting composition. Fig. 27 A polarizing microscope photograph of the composition is shown in FIG. Fig.28 Display Fig. 27 A partial enlargement of a microscope photograph. Fig.29 Schematic diagram showing the emulsified state in the composition.

[0232] Through the microscope photos, Fig.29 As shown, it was confirmed that the oil phase (oil droplets) 2 was contained in the gel composition 1 in the water phase 3. Thus, it was confirmed that an oil-in-water composition stably emulsified by the gel composition could be prepared. The particle size of the oil droplets was in the range of 1 to 2 μm. The oil-in-water composition can be used as a composition for external use on the skin.

[0233] Table 6

[0234]

[0235] [Barrier function test]

[0236] The barrier function of the prepared gel composition was tested. As a comparative test, a composition having a lamellar gel phase prepared without adding ceramide, phytosterol and higher fatty acid (Test Example 20) was also tested. Fig.30 A schematic diagram of the experimental setup is shown in FIG.

[0237] On filter paper 5 at 0.1 g / cm 3Apply the composition 1 in the amount of 100 μl and sandwich it with other filter paper 5. Allow it to dry overnight at room temperature of 50°C. Add degassed phosphate buffer to the receiver 7 side of the Franz-type diffusion cell 4, and place the filter paper 5 sandwiching the composition 1 to hydrate it for 1 hour. Next, add a sample 6 of a 0.2% fluorescein (manufactured by TCI) ethanol solution to the 0.5 mL provider side, and collect 200 μL of the solution in the receiver 7 after 23 hours. After collecting, add the same amount of phosphate buffer to the receiver 7. The sampled receiver was transferred to a 96-well plate, and the fluorescence intensity was measured at 485 nm / 535 nm using an ELISA reader (ARVO X3, manufactured by PerkinElmer). The measurement results are shown in Tables 7 and 8. The measurement results shown in Tables 7 and 8 are the average values ​​of the three measurement values. Fig.31 The fluorescence intensity comparison of the gel compositions shown in Table 7 is shown. Fig.32 The fluorescence intensity comparison of the gel compositions shown in Table 8 is shown.

[0238] The compositions of Test Examples 1 and 4 showed higher barrier function than the composition of Test Example 20 not containing ceramide, phytosterol and higher fatty acid. In addition, the composition of Test Example 4 containing phytosterol and higher fatty acid showed higher barrier function.

[0239] Test Example 21 in which hydrogenated lecithin was used instead of ceramide and Test Example 22 in which γ-oryzanol was used instead of phytosterol also showed high barrier function.

[0240] From this, it is considered that the gel composition of the present disclosure can exhibit a high barrier function when applied to the skin.

[0241] Table 7

[0242]

[0243] Table 8

[0244]

[0245] The gel composition and the oil-in-water composition of the present invention have been described based on the above-mentioned embodiments and examples, but are not limited to the above-mentioned embodiments and examples, and may include various deformations, changes and improvements of each disclosed element (including the elements described in the claims, the specification and the drawings) within the scope of the present invention and based on the basic technical concept of the present invention. In addition, various combinations / replacements or selections of each disclosed element are possible within the scope of the claims of the present invention.

[0246] Further problems, objects, and aspects (including modified aspects) of the present invention will become apparent from the entire disclosure of the present invention including the claims.

[0247] Regarding the numerical range described herein, even if there is no special description, it should be construed that any numerical value or range included in the range is specifically described herein.

[0248] Each claim in the patent claims and the following notes can realize any combination and reference relationship.

[0249] A part or all of the above-mentioned embodiments can also be described as the following supplementary notes, but are not limited to the following descriptions. Each supplementary note can also be combined with each claim described in the patent claims.

[0250] [Note 1]

[0251] A method for producing an oil-in-water composition comprises the following steps:

[0252] A mixing step of melting a first compound represented by the formula shown in Chemical 1, a second compound represented by the formula shown in Chemical 2, a third compound represented by the formula shown in Chemical 3, and a fourth compound comprising at least one selected from ceramide and lecithin to prepare a mixture;

[0253] A step of adding water to the mixture to prepare a lamellar gel phase; and

[0254] A step of including an oily component in the lamellar gel phase.

[0255] [Note 2]

[0256] The production method according to the supplementary note, wherein in the mixing step, a fifth compound including at least one selected from the group consisting of phytosterols, cholesterol and oryzanol is further added.

[0257] [Note 3]

[0258] The production method according to the supplementary note, wherein in the mixing step, a sixth compound including at least one selected from higher fatty acids having 14 to 22 carbon atoms is further added.

[0259] [Note 4]

[0260] According to the production method described in the supplementary note, in the step of adding water, the mixture is heated to a temperature within a range of ±15° C. with respect to the heating temperature before the addition.

[0261] [Note 5]

[0262] A method for using the gel composition and / or oil-in-water composition of the present disclosure in an external preparation for skin.

[0263] Industrial Availability

[0264] The gel composition and oil-in-water composition of the present disclosure can be applied to the body, such as skin, hair, etc. For example, the oil-in-water composition of the present disclosure can be applied to cosmetics (such as foundation, sunscreen cosmetics, base makeup, BB cream, etc.), hair styling materials, cleaning materials (such as cleansing milk, shampoo, etc.), etc.

[0265] Explanation of symbols

[0266] 1. Gel composition

[0267] 2 oil phase

[0268] 3. Water phase

[0269] 4Franz type diffusion cell

[0270] 5. Filter paper

[0271] 6. Sample

[0272] 7 Receivers.

Claims

1. A gel composition comprising: A first compound represented by the formula shown in the following chemical formula 1, A second compound represented by the formula shown in the following chemical formula 2, A third compound represented by the formula shown in the following chemical formula 3, and The fourth compound as a double-chain amphiphilic substance having a nitrogen atom, With respect to the total mass of the first compound, the second compound and the third compound, the first compound accounts for 49% to 88% by mass, the second compound accounts for 6% to 23% by mass, and the third compound accounts for 6% to 28% by mass. The fourth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass. [Chemistry 1] In the formula shown in Chemical 1, R 1 is at least one selected from a steroid skeleton and a cholesterol skeleton, R 2 is an alkylene group having 2 to 4 carbon atoms, and m represents an integer of 5 to 30; [Chemistry 2] In the formula shown in Chemical 2, R 3 is a straight-chain acyl or alkyl group having 16 to 24 carbon atoms, R 4 is an alkylene group having 2 to 4 carbon atoms, R 5 is a straight-chain acyl group or a straight-chain alkyl group having 16 to 24 carbon atoms, and n represents an integer of 4 to 8; [Chemistry 3] In the formula shown in Chemical 3, R 6 is a straight-chain acyl or alkyl group having 16 to 24 carbon atoms, R 7 is an alkylene group having 2 to 4 carbon atoms, and p is an integer of 5 to 30. 2 . The gel composition according to claim 1 , wherein the first compound, the second compound, the third compound and the fourth compound form a lamellar gel phase.

3. The gel composition according to claim 1, further comprising a fifth compound having a steroid skeleton, The fifth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass. 4 . The gel composition according to claim 3 , wherein the first compound, the second compound, the third compound, the fourth compound and the fifth compound form a lamellar gel phase.

5. The gel composition according to claim 1, further comprising: a sixth compound comprising at least one selected from higher fatty acids having 14 to 22 carbon atoms, The sixth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass. 6 . The gel composition according to claim 5 , wherein the first compound, the second compound, the third compound, the fourth compound and the sixth compound form a lamellar gel phase.

7. The gel composition according to claim 1, further comprising: The fifth compound having a steroid skeleton, and a sixth compound comprising at least one selected from higher fatty acids having 14 to 22 carbon atoms, The fifth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass. The sixth compound is present in an amount of 0.04 to 0.22 parts by mass relative to 1 part by mass of the total mass. 8 . The gel composition according to claim 7 , wherein the first compound, the second compound, the third compound, the fourth compound, the fifth compound and the sixth compound form a lamellar gel phase. 9 . The gel composition according to claim 3 , wherein the fifth compound is at least one selected from the group consisting of phytosterols, cholesterol and oryzanol. 10 . The gel composition according to claim 1 , wherein the total mass is 29% by mass to 66% by mass relative to the mass of the gel composition. 11 . The gel composition according to claim 1 , wherein the fourth compound is at least one selected from the group consisting of ceramide and lecithin. 12 . The gel composition according to claim 11 , wherein the ceramide is at least one selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 5, and ceramide 6. 13 . The gel composition according to claim 1 , which has a peak indicating a hexagonal crystal structure in an X-ray scattering pattern. 14 . The gel composition according to claim 1 , further comprising water.

15. An oil-in-water composition comprising: The gel composition according to any one of claims 1 to 14, and oily ingredients, At least a part of the oily component is contained in the gel composition.

16. The oil-in-water composition according to claim 15, further comprising water. 17 . The oil-in-water composition according to claim 15 , wherein the amount of the oil component is 1 to 50 parts by mass based on 1 part by mass of the gel composition.

18. The oil-in-water composition according to any one of claims 15 to 17, wherein the oil component comprises at least one selected from di(phytosteryl / octyldodecyl) lauroyl glutamate, polybutylene glycol, castor oil, and macadamia nut oil fatty acid phytosteryl ester.

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