Calamine composition as well as preparation method and application thereof

Abstract

The invention discloses a calamine composition and a preparation method and application thereof.According to the calamine composition, xanthan gum and sodium polyacryloyldimethyl taurate serve as a composite thickening agent, cetearyl glucoside / sorbitan olivate / cetostearyl alcohol and sorbitan stearate serve as emulsifiers, and the calamine composition is prepared through the steps that the composite thickening agent is added, practice shows that the calamine composition can be improved in the aspect of comprehensive performance, high-content calamine can be stabilized in a water-based emulsion system, the calamine composition can be stored for a long time in a wide temperature range, and the calamine composition can be used for preparing cosmetics and the like capable of calming, relieving and repairing damaged skin.

Description

Technical Field

[0001] The invention relates to the field of daily chemical products, in particular to a calamine composition and a preparation method and application thereof. Background Art

[0002] Calamine is a carbonate mineral, mainly containing zinc carbonate. It is a block aggregate in irregular blocks with a powdery, dull, uneven, porous, honeycomb-like surface. It is mostly used in medicine to treat red eyes, cataracts, ulcers and skin eczema. At the same time, it can help calm, soothe and repair damaged skin when applied to the skin. At present, in the field of cosmetics, calamine is mainly used in oil-in-water formulation products. Water-in-oil formulation products generally disperse calamine evenly in their systems, but the stability of the emulsion is difficult to control. The emulsion system is unstable, especially when stored for a long time, in a low-temperature environment or a high-temperature environment, it is easy to stratify or leak water, which is not conducive to consumer experience. Summary of the invention

[0003] The object of the present invention is to overcome one or more deficiencies in the prior art and to provide a new calamine composition which can stabilize a high content of calamine in an aqueous emulsion system and can be stored for a long time within a wide temperature range.

[0004] The invention also provides a preparation method of the calamine composition and application of the calamine composition in preparing cosmetics.

[0005] To achieve the above object, a technical solution adopted by the present invention is: a calamine composition, the calamine composition comprising:

[0006] (i) 9.0 wt % or less of calamine, based on the total weight of the calamine composition;

[0007] (ii) 0.01 wt % to 2.0 wt % of a thickener based on the total weight of the calamine composition, wherein the thickener comprises a complex of xanthan gum and sodium polyacryloyldimethyl taurate, and the mass ratio of the xanthan gum to the sodium polyacryloyldimethyl taurate is 1:2-15;

[0008] (iii) 0.1 wt % to 5.0 wt % of an emulsifier based on the total weight of the calamine composition, wherein the emulsifier comprises cetearyl glucoside / sorbitan olivate / cetearyl alcohol and sorbitan stearate, and the mass ratio of cetearyl glucoside / sorbitan olivate / cetearyl alcohol to sorbitan stearate is 4-10:1; and

[0009] (iv) Water.

[0010] According to some preferred aspects of the present invention, the calamine is present in the calamine composition at 0.5% to 8.5% by weight relative to the total weight of the calamine composition. In some embodiments of the present invention, the calamine is present in the calamine composition at 2% to 8% by weight relative to the total weight of the calamine composition. Further, in a specific case, the content of calamine relative to the total weight of the calamine composition includes but is not limited to: 0.5% by weight, 0.6% by weight, 0.7% by weight, 0.8% by weight, 0.9% by weight, 1% by weight, 1.2% by weight, 1.5% by weight, 1.8% by weight, 2% by weight, 2.2% by weight, 2.5% by weight, 2.8% by weight, 3% by weight, 3.3% by weight, 3.5% by weight, 3.8% by weight, 4% by weight , 4.5 weight%, 5 weight%, 5.5 weight%, 5.8 weight%, 5.9 weight%, 6.0 weight%, 6.2 weight%, 6.4 weight%, 6.5 weight%, 6.6 weight%, 6.8 weight%, 7.0 weight%, 7.2 weight%, 7.3 weight%, 7.5 weight%, 7.6 weight%, 7.7 weight%, 7.8 weight%, 7.9 weight%, 8.0 weight%, 8.2 weight%, 8.4 weight%, 8.5 weight%, etc.

[0011] According to some preferred aspects of the present invention, the thickener is present in the calamine composition at 0.1% to 1.0% by weight relative to the total weight of the calamine composition. In some embodiments of the present invention, the thickener is present in the calamine composition at 0.15% to 0.55% by weight relative to the total weight of the calamine composition. Further, in a specific case, the thickener includes, but is not limited to, 0.1 weight%, 0.12 weight%, 0.15 weight%, 0.2 weight%, 0.25 weight%, 0.28 weight%, 0.3 weight%, 0.31 weight%, 0.32 weight%, 0.33 weight%, 0.34 weight%, 0.35 weight%, 0.36 weight%, 0.37 weight%, 0.38 weight%, 0.39 weight%, 0.4 weight%, 0.41 weight%, 0.42 weight%, 0.45 weight%, 0.48 weight%, 0.5 weight%, 0.52 weight%, 0.55 weight%, 0.6 weight%, 0.7 weight%, etc. relative to the total weight of the calamine composition.

[0012] According to some preferred aspects of the present invention, the emulsifier is present in the calamine composition at 1.5% to 4.0% by weight relative to the total weight of the calamine composition. In some embodiments of the present invention, the emulsifier is present in the calamine composition at 1.8% to 3.5% by weight relative to the total weight of the calamine composition. Further, in a specific case, the emulsifier includes but is not limited to 1.5% by weight, 1.6% by weight, 1.7% by weight, 1.8% by weight, 1.9% by weight, 2% by weight, 2.1% by weight, 2.2% by weight, 2.3% by weight, 2.4% by weight, 2.5% by weight, 2.8% by weight, 2.9% by weight, 3% by weight, 3.2% by weight, 3.3% by weight, 3.4% by weight, 3.5% by weight, 3.8% by weight, 4.0% by weight, etc.

[0013] According to some preferred aspects of the present invention, the mass ratio of the xanthan gum to the sodium polyacryloyldimethyl taurate is 1:5-8, for example, it can be 1:5.2, 1:5.3, 1:5.4, 1:5.5, 1:5.6, 1:5.7, 1:5.8, 1:5.9, 1:6, 1:6.2, 1:6.4, 1:6.5, 1:6.6, 1:6.7, 1:6.8, 1:6.9, 1:7, etc.

[0014] According to some preferred aspects of the present invention, the feeding mass ratio of the cetearyl glucoside / sorbitan olivate / cetearyl alcohol to the sorbitan stearate is 5-8.5:1, for example, it can be 5.2:1, 5.4:1, 5.5:1, 5.6:1, 5.7:1, 5.8:1, 6:1, 6.2:1, 6.3:1, 6.4:1, 6.5:1, 6.6:1, 6.7:1, 6.8:1, 6.9:1, 7:1, 7.1:1, 7.2:1, 7.5:1, 8:1 and the like.

[0015] In some embodiments of the present invention, the average particle size of the calamine is less than or equal to 30 μm.

[0016] According to some preferred aspects of the present invention, the mass ratio of the calamine, the thickener and the emulsifier is 1: 0.04-0.2: 0.25-0.9, further 1: 0.04-0.15: 0.25-0.65. According to a specific aspect of the present invention, the mass ratio of the calamine, the thickener and the emulsifier is 1: 0.06-0.1: 0.5-0.65.

[0017] In some embodiments of the present invention, the calamine composition further comprises a combination of one or more selected from polyols, chelating agents, oil wax components, and skin conditioners.

[0018] Further, the polyol comprises a combination of one or more selected from glycerol, 1,2-hexanediol, and methylpropanediol. In the present invention, the composition can have moisturizing effects and the like through the synergistic combination of polyols, thickeners, etc. The chelating agent comprises disodium EDTA, which can be complexed with metal ions introduced into the formula, reduce the influence of metal ions on the formula system, and has a stabilizing effect. The oil wax component comprises a combination of one or more selected from cetearyl alcohol, ethylhexyl stearate, and methyl polytrimethylsiloxane, and further, the oil wax component has a feed mass ratio of 1:3-5:1.5-2.5. In the present invention, the oil wax component can play a certain stabilizing role, help stabilize the stability of the emulsion cosmetics, and help make it easier to apply and absorb. The skin conditioner comprises a combination of one or more selected from p-hydroxyacetophenone, ethylhexylglycerin, trehalose, niacinamide, and adenosine.

[0019] In some embodiments of the present invention, the calamine composition comprises an aqueous phase, a thickener, an oil phase and calamine, and the oil phase comprises an emulsifier. Further, the aqueous phase comprises water, glycerol, 1,2-hexanediol, methylpropanediol, a chelating agent, p-hydroxyacetophenone, trehalose, nicotinamide, and adenosine. In some embodiments of the present invention, the water is deionized water.

[0020] Further, the oil phase comprises an oil wax component and an emulsifier. In some embodiments of the present invention, the oil wax component may be a liquid oil wax and / or a solid oil wax, wherein the liquid oil wax may include but is not limited to ethylhexyl stearate, methyl trimethicone, etc., and the solid oil wax may include but is not limited to cetearyl alcohol.

[0021] According to some specific aspects of the present invention, the calamine composition comprises, by weight percentage: 1 to 5% by weight of glycerol, 1 to 3% by weight of 1,2-hexanediol, 1 to 3% by weight of methylpropanediol, 0.005 to 0.5% by weight of a chelating agent, 1 to 3% by weight of trehalose, 1 to 3% by weight of nicotinamide, 0.001 to 0.2% by weight of adenosine, 0.05 to 0.5% by weight of p-hydroxyacetophenone, 0.02 to 0.2% by weight of xanthan gum, 0.1 to 0.5% by weight of stearic acid, and 0.1 to 0.5% by weight of succinic acid. % sodium polyacryloyldimethyl taurate, 0.1 wt % to 1 wt % cetearyl alcohol, 0.5 wt % to 4 wt % cetearyl glucoside / sorbitan olivate / cetearyl alcohol, 0.1 wt % to 1 wt % sorbitan stearate, 1 wt % to 3 wt % ethylhexyl stearate, 0.5 wt % to 1.5 wt % methyl trimethicone, 0.01 wt % to 0.3 wt % ethylhexylglycerin, 0.1 wt % to 9.0 wt % calamine, and the amount of water is adjusted so that the weight of the calamine composition meets 100 wt %.

[0022] Another technical solution provided by the present invention is a method for preparing the calamine composition described above, the method comprising: dispersing water-soluble components in water to prepare an aqueous phase, and then adding a thickener to prepare a first phase; mixing an emulsifier and an oil wax component to prepare an oil phase as a second phase; adding the second phase to the first phase, homogenizing, and adding calamine after homogenization, and mixing.

[0023] Furthermore, in the process of preparing the water phase, after the raw materials in the water phase are evenly mixed, the thickener is slowly added under stirring conditions and heated to 75-80°C.

[0024] Further, the emulsifier and the oil wax component are mixed to form an oil phase as the second phase, and heated to 75-80°C; then the second phase is slowly added to the first phase under homogenization; further, the homogenization temperature is 75-80°C, the homogenization speed is 5500-6500rpm, and the homogenization time is 5-10min.

[0025] Further, after homogenization is completed, the temperature is lowered to 40-45° C., and then calamine is added, and homogenization is continued, the homogenization speed is 5500-6500rpm, and the homogenization time is 1-5min. After calamine is added and homogenization is completed, the temperature is lowered to 30-35° C., and deaeration treatment is performed to obtain the calamine composition.

[0026] Another technical solution provided by the present invention is: use of the calamine composition described above in the preparation of cosmetics, wherein the cosmetics can calm, soothe and repair damaged skin.

[0027] Due to the application of the above technical scheme, the present invention has the following advantages compared with the prior art: the present invention is based on the problems in the prior art that calamine has poor stability, limited calamine addition, poor long-term storage performance, etc. when it is applied to an aqueous emulsion system such as an oil-in-water dosage form. During a large number of experimental studies, it was unexpectedly found that by using xanthan gum and sodium polyacryloyldimethyl taurate as a composite thickener, and using cetearyl glucoside / sorbitan olivate / cetearyl alcohol and sorbitan stearate as emulsifiers, the above comprehensive performance can be improved, not only can a high content of calamine be stabilized in the aqueous emulsion system, but it can also be stored for a long time within a wider temperature range. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 The material photos of Example 1 and Comparative Examples 1-3 of the present invention on the day of the experiment;

[0029] Figure 2 To use a scraper Figure 1 A photo of the material body obtained after the material body of Example 1 is scraped out;

[0030] Figure 3 The material photos of Examples 2-3 and Comparative Examples 4-6 of the present invention on the day of the experiment;

[0031] Figure 4 To use a scraper Figure 3 Photos of the materials obtained after scraping out the materials of Comparative Examples 4 and 6;

[0032] Figure 5 The material photos of comparative examples 7-8, embodiments 4-5 and comparative example 11 of the present invention on the day of the experiment;

[0033] Figure 6 To use a scraper Figure 5 Photos of the materials obtained after scraping out the materials of Comparative Examples 7-8;

[0034] Figure 7 This is a photo of the material body on the day of the experiment of Comparative Examples 9-10 of the present invention;

[0035] Figure 8 To use a scraper Figure 7 The photo of the material obtained after the material of Comparative Examples 9-10 was scraped out;

[0036] Fig. 9 The material bodies of Example 1 and Comparative Examples 1-3 of the present invention after being placed for 2 weeks;

[0037] Fig.10 The material bodies of Examples 2-3 and Comparative Examples 4-6 of the present invention after being placed for one week;

[0038] Fig.11 To use a scraper Fig.10 Photos of the materials obtained after scraping out the materials of Comparative Examples 4 and 6;

[0039] Fig.12 The material bodies of Comparative Examples 7-8, Examples 4-5 and Comparative Example 11 of the present invention after being placed for one week;

[0040] Fig.13 To use a scraper Fig.12 Photos of the materials obtained after scraping out the materials of Comparative Examples 7-8;

[0041] Fig.14 This is a photo of the material body of Comparative Examples 9-10 of the present invention after being placed for one week;

[0042] Fig.15 The material bodies of Example 1 and Comparative Examples 1-3 of the present invention after being placed in a freezing condition of -18°C for 2 weeks;

[0043] Fig.16 The material bodies of Examples 2-3 and Comparative Examples 4-6 of the present invention after being placed in a freezing condition of -18°C for one week;

[0044] Fig.17 To use a scraper Fig.16 Photos of the materials obtained after scraping out the materials of Examples 2-3 and Comparative Example 4;

[0045] Fig.18 To use a scraper Fig.16 Photos of the materials obtained after scraping out the materials of Comparative Examples 5-6;

[0046] Fig.19 The material bodies of Comparative Examples 7-8, Examples 4-5 and Comparative Example 11 of the present invention after being placed under a freezing condition of -18°C for one week;

[0047] Fig. 20 To use a scraper Fig.19 Photos of the materials obtained after scraping out the materials of Comparative Examples 7-8;

[0048] Fig.21 To use a scraper Fig.19 A photo of the material obtained after the material of Comparative Example 11 is scraped out;

[0049] Fig. 22 This is a photo of the material of Comparative Example 9-10 of the present invention after being placed in a freezing condition of -18°C for one week;

[0050] Fig.23 The material bodies of Example 1 and Comparative Examples 1-3 of the present invention after being placed at 50° C. for 2 weeks;

[0051] Fig.24The material photos of Examples 2-3 and Comparative Examples 4-6 after being placed at 50°C for one week;

[0052] Fig.25 To use a scraper Fig.24 A photo of the material body obtained after the material body of Example 3 is scraped out;

[0053] Fig.26 The material bodies of Comparative Examples 7-8, Examples 4-5 and Comparative Example 11 of the present invention after being placed at 50° C. for one week;

[0054] Fig. 27 This is a separate comparison diagram of the material body photos of Comparative Examples 7-8 and Comparative Example 11 of the present invention after being placed at 50° C. for one week;

[0055] Fig.28 This is a photo of the material of Comparative Examples 9-10 of the present invention after being placed at 50° C. for one week;

[0056] Fig.29 To use a scraper Fig.28 Photograph of the material obtained after scraping out the material of Comparative Examples 9-10. DETAILED DESCRIPTION

[0057] The above scheme is further described below in conjunction with specific embodiments; it should be understood that these embodiments are used to illustrate the basic principles, main features and advantages of the present invention, and the present invention is not limited to the scope of the following embodiments; the implementation conditions adopted in the embodiments can be further adjusted according to specific requirements, and the implementation conditions not specified are usually the conditions in conventional experiments.

[0058] Unless otherwise specified in the following examples, all raw materials are commercially available or prepared by conventional methods in the art.

[0059] Methylpropanediol (isobutylene glycol) was purchased from Kunshan Shenliu Trading Co., Ltd.; adenosine was purchased from Henan Dingxin Pharmaceutical Technology Co., Ltd.; trehalose was purchased from NAGASE VIITA CO., LTD., brand TREHALOSE 100; niacinamide was purchased from DSM, brand Niacinamide PC; xanthan gum was purchased from CP KELCO, brand F XANTHAN GUM; sodium polyacryloyldimethyl taurate, purchased from CLARIANT, brand Aristoflex Silk; carbomer 980, purchased from Lubrizol, brand 980; carbomer 981, purchased from Lubrizol, brand 981; ammonium acryloyldimethyl taurate / VP copolymer, purchased from Shanghai Changyun Industrial Co., Ltd., brand SY VIS-A90; sodium polyacrylate, purchased from BASF, brand SP; cetearyl alcohol, purchased from BASF, brand O; Cetearyl Glucoside / Sorbitan Olivate / Cetearyl Alcohol, purchased from SHARONPERSONAL CARE, brand EMULPHARMA K10 RSPO MB; Sorbitan Stearate, purchased from Shanghai Changyun Industrial Co., Ltd., brand SY EMU-S001; Polyglyceryl-3 Methyl Glucose Distearate, purchased from EVONIK, brand Care450MB; Glyceryl Stearate / PEG-100 Stearate, purchased from Shanghai Changyun Industrial Co., Ltd., brand SY EMU-A1118; Polyglyceryl-3 Distearate / Glyceryl Stearate Citrate, purchased from EVONIK, brand NC MB; cetearyl olivate / sorbitan olivate, purchased from Shanghai Ronghai Biotechnology Co., Ltd., brand name Olivem 1000; ethylhexyl stearate, purchased from NFC CORPORATION, brand name NF-Ester EHS; methyl trimethicone, purchased from SHIN-ETSU CHEMICAL CO., LTD, brand name TMF-1.5; calamine, purchased from JUHWAN BIO CELL, brand name JH-Calamine.

[0060] Examples 1-3

[0061] This example provides a calamine composition and a preparation method thereof. The formula of the calamine composition is shown in Table 1.

[0062] Table 1

[0063]

[0064] The preparation method of the calamine composition comprises:

[0065] Mix all ingredients in the water phase to make the water phase, then add the thickener and heat to 75-80°C to make the first phase;

[0066] Mix all ingredients in the oil phase and heat to 75-80°C to prepare the oil phase as the second phase;

[0067] Add the second phase to the first phase and homogenize at a temperature of 75-80°C, a homogenization speed of 6000 rpm, and a homogenization time of 10 min. After homogenization, cool to about 45°C, add calamine, mix, and continue homogenizing at a homogenization speed of 6000 rpm for 5 min.

[0068] After homogenization, the temperature is lowered to about 35° C., and a material body is obtained after degassing, namely, the calamine composition of the present invention.

[0069] Embodiment 4-5

[0070] This example provides a calamine composition and a preparation method thereof. The formula of the calamine composition is shown in Table 2.

[0071] Table 2

[0072]

[0073] The preparation method is the same as that of Example 1.

[0074] Comparative Examples 1-3

[0075] This example provides a calamine composition and a preparation method thereof. The formula of the calamine composition is shown in Table 3.

[0076] Table 3

[0077]

[0078] The preparation method is the same as that of Example 1.

[0079] Comparative Examples 4-8

[0080] This example provides a calamine composition and a preparation method thereof. The formula of the calamine composition is shown in Table 4.

[0081] Table 4

[0082]

[0083]

[0084] The preparation method is the same as that of Example 1.

[0085] Comparative Examples 9-11

[0086] This example provides a calamine composition and a preparation method thereof. The formula of the calamine composition is shown in Table 5.

[0087] Table 5

[0088]

[0089]

[0090] The preparation method is the same as that of Example 1.

[0091] Performance Testing

[0092] In the stability test, the material condition was observed on the day (25℃), 1 week later (25℃), 2 weeks later (25℃), 1 week later (frozen, -18℃), 2 weeks later (frozen, -18℃), 1 week later (50℃), and 2 weeks later (50℃).

[0093] (1) Material stability on the day of the experiment of Example 1 and Comparative Examples 1-3 (25°C)

[0094] For detailed results, see Figure 1 As shown, it can be clearly seen that the material body of Example 1 has no abnormality, the material body of Comparative Example 1 has slight stratification (the bottom is white), and the material bodies of Comparative Examples 2-3 have basically no abnormality; at the same time, see Figure 2 As shown, the material of Example 1 is scraped out with a scraper and the material is observed. Figure 2 It shows that the surface of the material of Example 1 is smooth and free of particles, and the material is uniform and free of agglomerates. Figure 2 In the photo on the middle left, the material body is scraped very thinly, but still no particles are seen, indicating that the material body of Example 1 of the present invention has excellent stability.

[0095] (2) Material stability of Examples 2-3 and Comparative Examples 4-6 on the day of the experiment (25°C)

[0096] For detailed results, see Figure 3 As shown, it can be clearly seen that the materials of Examples 2-3 have no abnormalities, particles are precipitated on the surface of the materials of Comparative Examples 4 and 6, and the material of Comparative Example 5 has no abnormalities; the materials of Comparative Examples 4 and 6 can be further seen in the photos after the materials are scraped out with a scraper ( Figure 4 ), it can be clearly seen that the scraped material contains a lot of particles, and the particle precipitation is obvious, indicating that its stability is poor.

[0097] (3) Material stability (25°C) on the day of the experiment of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11

[0098] For detailed results, see Figure 5 As shown, particles are precipitated on the surface of the materials of Comparative Examples 7-8, and there is no abnormality in the materials of Examples 4-5 and Comparative Example 11; the materials of Comparative Examples 7-8 can be further seen in the photos after the materials are scraped out with a scraper ( Figure 6 ), it can be clearly seen that the scraped material contains a lot of particles, and the particle precipitation is very obvious (more obvious in Comparative Example 7), indicating that its stability is poor.

[0099] (4) Material stability on the day of the experiment of comparative example 9-10 (25°C)

[0100] For detailed results, see Figure 7 As shown, particles are precipitated on the surface of the material bodies of Comparative Examples 9-10, and further reference can be made to the photo of the material bodies being scraped out with a scraper ( Figure 8 ), there are obvious particles on the surface of the scraped material.

[0101] (5) Material stability of Example 1 and Comparative Examples 1-3 after 2 weeks of storage (25°C)

[0102] For detailed results, see Fig. 9 As shown, it can be clearly seen that the material body of Example 1 has no abnormality, the material body of Comparative Example 1 has water discharge and stratification, and a large amount of water appears on the top, the material body of Comparative Example 2 begins to discharge water, and a small amount of water begins to precipitate on the top, and the material body of Comparative Example 3 also discharges water and stratifies, and the underwater material body begins to agglomerate.

[0103] (6) Material stability of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage (25°C)

[0104] For detailed results, see Fig.10 As shown, it can be seen that the materials of Examples 2-3 have no abnormalities, particles are precipitated on the surface of the materials of Comparative Examples 4 and 6, and the material of Comparative Example 5 has basically no abnormalities; the materials of Comparative Examples 4 and 6 can be further seen in the photos after the materials are scraped out with a scraper ( Fig.11 ), it can be clearly seen that the scraped material contains a lot of particles, and the particle precipitation is obvious, indicating that its stability is poor.

[0105] (7) Material stability of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage (25°C)

[0106] For detailed results, see Fig.12 As shown, the materials of Comparative Examples 7-8 all have particles precipitated, while the materials of Examples 4-5 and Comparative Example 11 are basically normal. The materials of Comparative Examples 7-8 can be further seen in the photos after the materials are scraped out with a scraper ( Fig.13 ), among which, the amount of particle precipitation in Comparative Example 7 is very large, and a small amount of particle precipitation is also present in Comparative Example 8.

[0107] (8) Material stability of comparative examples 9-10 after 1 week of storage (25°C)

[0108] For detailed results, see Fig.14 As shown, after the material body is scraped out from the lower side with a scraper, obvious particles appear on the surface of the scraped material body.

[0109] (9) Material stability of Example 1 and Comparative Examples 1-3 after 2 weeks of storage (frozen at -18°C)

[0110] For detailed results, see Fig.15 As shown, it can be seen that the material body of Example 1 has no abnormality, the material body of Comparative Example 1 has water discharge and stratification, a large amount of water appears on the top, and obvious material body agglomeration occurs; Comparative Example 2 has basically no abnormality, the material body of Comparative Example 3 also has water discharge and stratification, and the underwater material body has serious agglomeration.

[0111] (10) Material stability of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage (frozen at -18°C)

[0112] For detailed results, see Fig.16 As shown, it can be seen that the surface of the material body of Examples 2-3 is rough, particles are precipitated on the surface of the material body of Comparative Examples 4 and 6, and the surface of the material body of Comparative Example 5 is rough; further, the material body scraped out by their scrapers can be seen, see Fig.17 and Fig.18 As shown, Fig.17 In the embodiment 2, the material body has obvious pits, showing a roughening phenomenon, and the material body of the embodiment 3 is uneven, and the roughening phenomenon begins to appear; the surface granularity of the comparative example 4 is very serious, and a large number of particles appear. Fig.18 The material of Comparative Example 5 is uneven and begins to become coarse. The material of Comparative Example 6 has a very obvious granular feel and a large amount of granular precipitation.

[0113] (11) Material stability of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage (frozen at -18°C)

[0114] For detailed results, see Fig.19 As shown, it can be seen that the materials of Examples 4-5 are basically normal, the surfaces of the materials of Comparative Examples 8 and 11 are rough, and particles are precipitated on the surface of the material of Comparative Example 7; further, the materials scraped out by their scrapers can be seen. Fig. 20 and Fig.21 As shown, Fig. 20 Compared with the material of Example 1, it can be clearly seen that a large amount of particles are precipitated in the material of Comparative Example 7, and the surface of the material of Comparative Example 8 is seriously roughened; Fig.21 Compared with the material of Example 1, it can be clearly seen that the material of Comparative Example 11 has a very serious coarsening phenomenon.

[0115] (12) Material stability of comparative examples 9-10 after 1 week of storage (frozen at -18°C)

[0116] For detailed results, see Fig. 22 As shown, after the material body is scraped out from the lower side with a scraper, particles appear on the surface of the scraped material body.

[0117] (13) Material stability of Example 1 and Comparative Examples 1-3 after 2 weeks of storage (50°C)

[0118] For detailed results, see Fig.23 As shown, it can be seen that the material body of Example 1 is normal, while the material bodies of Comparative Examples 1-3 all begin to release water, stratify and change color.

[0119] (14) Material stability of Examples 2-3 and Comparative Examples 4-6 after 1 week of storage (50°C)

[0120] For detailed results, see Fig.24As shown, it can be seen that Example 2 has no abnormality, Example 3 has signs of stratification, Comparative Examples 4 and 6 have stratification, and Comparative Example 5 has basically no abnormality; the material body of Example 3 can be further referred to the material body scraped out by a scraper Fig.25 , obvious color bands can be seen in the material.

[0121] (15) Material stability of Comparative Examples 7-8, Examples 4-5, and Comparative Example 11 after 1 week of storage (50°C)

[0122] For detailed results, see Fig.26 As shown, Comparative Examples 7-8 and Comparative Example 11 all had water stratification, and the material bodies of Examples 4-5 had no abnormalities;

[0123] The materials of Comparative Examples 7-8 and Comparative Example 11 can be further seen in the separate comparison diagrams - Fig. 27 , the water stratification phenomenon is very obvious.

[0124] (16) Material stability of comparative examples 9-10 after 1 week of storage (50°C)

[0125] For detailed results, see Fig.28 and 29 As shown, in the photo after the material is scraped out with a scraper, it can be clearly seen that particles appear on the surface of the scraped material.

[0126] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

[0127] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

Claims

1. A calamine composition, characterized in that, The calamine composition comprises: (i) 9.0 wt % or less of calamine, based on the total weight of the calamine composition; (ii) 0.01 wt % to 2.0 wt % of a thickener based on the total weight of the calamine composition, wherein the thickener comprises a complex of xanthan gum and sodium polyacryloyldimethyl taurate, and the mass ratio of the xanthan gum to the sodium polyacryloyldimethyl taurate is 1:2-15; (iii) 0.1 wt % to 5.0 wt % of an emulsifier based on the total weight of the calamine composition, wherein the emulsifier comprises cetearyl glucoside / sorbitan olivate / cetearyl alcohol and sorbitan stearate, and the mass ratio of cetearyl glucoside / sorbitan olivate / cetearyl alcohol to sorbitan stearate is 4-10:1; and (iv) Water.

2. The calamine composition according to claim 1, characterized in that The calamine is present in the calamine composition at 0.5% to 8.5% by weight relative to the total weight of the calamine composition; and / or, The thickener is present in the calamine composition at 0.1 wt % to 1.0 wt % relative to the total weight of the calamine composition; and / or, The emulsifier is present in the calamine composition at 1.5% to 4.0% by weight relative to the total weight of the calamine composition.

3. The calamine composition according to claim 2, characterized in that The calamine is present in the calamine composition at 2% to 8% by weight relative to the total weight of the calamine composition; and / or, The thickener is present in the calamine composition at 0.15% to 0.55% by weight relative to the total weight of the calamine composition; and / or, The emulsifier is present in the calamine composition at 1.8% to 3.5% by weight relative to the total weight of the calamine composition.

4. The calamine composition according to claim 1, characterized in that The mass ratio of the xanthan gum to the sodium polyacryloyldimethyl taurate is 1:5-8.

5. The calamine composition according to claim 1, characterized in that The mass ratio of the cetearyl glucoside / sorbitan olivate / cetearyl alcohol to the sorbitan stearate is 5-8.5:

1.

6. The calamine composition according to claim 1, characterized in that The average particle size of the calamine is less than or equal to 30 μm.

7. The calamine composition according to claim 1, characterized in that The mass ratio of the calamine, the thickener and the emulsifier is 1:0.04-0.2:0.25-0.9, and further 1:0.04-0.15:0.25-0.

65.

8. The calamine composition according to claim 1, characterized in that The calamine composition further comprises a combination of one or more selected from polyols, chelating agents, oil wax components, and skin conditioning agents; Further, the polyol comprises a combination of one or more selected from glycerol, 1,2-hexanediol, and methylpropylene glycol; The chelating agent comprises disodium EDTA; The oil wax component comprises a combination of one or more selected from cetearyl alcohol, ethylhexyl stearate, and methyl trimethicone, and further, the oil wax component is fed in a mass ratio of 1:3-5:1.5-2.5; The skin conditioning agent comprises a combination of one or more selected from p-hydroxyacetophenone, ethylhexylglycerin, trehalose, niacinamide, and adenosine.

9. A method for preparing the calamine composition according to any one of claims 1 to 8, characterized in that: The preparation method comprises: Dispersing water-soluble ingredients in water to prepare an aqueous phase, and then adding a thickener to prepare a first phase; The emulsifier and the oil wax component are mixed to prepare an oil phase as the second phase; Add the second phase to the first phase and mix. After homogenization, add calamine and mix.

10. Use of the calamine composition according to any one of claims 1 to 8 in preparing cosmetics, wherein the cosmetics can calm, soothe and repair damaged skin.

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