Preparation method and application of nicotinamide whitening powder

Abstract

The invention relates to the technical field of whitening powder, in particular to a preparation method and application of nicotinamide whitening powder, and the preparation method comprises the following steps: dropwise adding a nicotinamide-ellagic acid whitening agent mixed solution into a pea protein solution, and carrying out spray drying to form pea protein microcapsules; carbomer and hydroxyethyl cellulose are added into water to form a colloidal solution; sequentially adding butanediol, glycerol, trehalose, panthenol, 1, 2-hexanediol and a polyol humectant, and stirring to obtain a mixed solution; adding p-hydroxyacetophenone, sodium pyrosulfite, pea protein microcapsules, 4D bio-enzyme, a soothing and repairing agent, sodium thiosulfate, arginine and allantoin into the mixed solution, and stirring; and drying the mixed solution through a spray dryer to obtain the nicotinamide whitening powder. The nicotinamide whitening powder disclosed by the invention is wrapped by the pea protein microcapsules, so that light, heat and oxygen are effectively blocked, the decomposition and oxidation risks of nicotinamide and ellagic acid are reduced, and the shelf life is prolonged.

Description

Technical Field

[0001] The invention relates to the technical field of whitening powder, and in particular to a preparation method and application of nicotinamide whitening powder. Background Art

[0002] As people pay more and more attention to skin whitening, the market for whitening products shows a sustained growth trend; niacinamide, as a widely recognized whitening ingredient, is widely used in various whitening products because it can effectively inhibit the transfer of melanin from melanocytes to keratinocytes, thereby reducing skin pigmentation and brightening skin tone; ellagic acid also has excellent whitening effects. It can not only inhibit the activity of tyrosinase and reduce melanin production, but also has antioxidant ability, which can scavenge free radicals and protect the skin from oxidative damage, further contributing to the whitening effect.

[0003] However, the existing niacinamide whitening powder still has some urgent problems to be solved in terms of preparation and product performance: niacinamide and ellagic acid are sensitive to light, heat and oxygen. In the traditional preparation process, such as high-temperature drying, as well as product storage and use, long-term exposure to light and oxygen environment can easily lead to niacinamide decomposition and ellagic acid oxidation, thereby reducing the whitening effect. This not only affects the quality stability of the product, but also makes it difficult for consumers to obtain a continuous and reliable whitening effect. In view of this, we propose a preparation method of niacinamide whitening powder and its application. Summary of the invention

[0004] The object of the present invention is to provide a method for preparing niacinamide whitening powder and its application, so as to solve the problem that niacinamide and ellagic acid are sensitive to light, heat and oxygen as mentioned in the above background technology. In the traditional preparation process, such as high-temperature drying, as well as product storage and use, long-term exposure to light and oxygen environment can easily lead to decomposition of niacinamide and oxidation of ellagic acid, thereby reducing the whitening effect. This not only affects the quality stability of the product, but also makes it difficult for consumers to obtain a continuous and reliable whitening effect.

[0005] The present invention provides a method for preparing nicotinamide whitening powder, comprising the following steps: S1.1, adding the nicotinamide-ellagic acid whitening agent mixed solution dropwise to the pea protein solution, and forming pea protein microcapsules by spray drying; The microcapsule shell formed by pea protein can serve as a physical barrier to effectively block the exposure to ultraviolet rays and other light. Nicotinamide and ellagic acid whitening agents are wrapped inside, reducing direct contact with light and reducing oxidation and decomposition reactions caused by light, thereby better maintaining their chemical structure and whitening activity; during the preparation process, such as spray drying or other heating steps, and the temperature changes that may occur during the storage of the product, the pea protein microcapsules can isolate the internal niacinamide and ellagic acid whitening agents from external heat to a certain extent, preventing them from decomposing or inactivating in high temperature environments. Because pea protein has a certain degree of thermal stability, it can provide a relatively stable microenvironment for the active ingredients inside, ensuring that within the conventional processing and storage temperature range (for example, in an environment below 40°C), the whitening effect of niacinamide and ellagic acid is not significantly affected.

[0006] Pea protein microcapsules can reduce the contact between oxygen and niacinamide and ellagic acid whitening agents. Oxygen is one of the key factors leading to the oxidation of ingredients. By encapsulating the active ingredients, the probability of oxidation reactions can be reduced. For example, during storage, unencapsulated niacinamide and ellagic acid whitening agents may gradually lose their activity due to reaction with oxygen in the air, while the encapsulated ingredients can maintain the content of their active ingredients for a longer period of time, thereby extending the shelf life of the product.

[0007] S1.2, add 0.1-0.2 parts by weight of carbomer and 0.05-0.1 parts by weight of hydroxyethyl cellulose to 80-85 parts by weight of water, and stir at a speed of 200-300 r / min for 30-60 min to form a colloidal solution; then add 3-5 parts by weight of butylene glycol, 2-4 parts by weight of glycerol, 0.8-1.2 parts by weight of trehalose, 0.2-0.6 parts by weight of panthenol, 0.2-0.6 parts by weight of 1,2-hexanediol and 0.3-0.5 parts by weight of a polyol moisturizer in sequence, and stir to obtain a mixed solution; S1.3, add 0.2-0.6 parts by weight of p-hydroxyacetophenone, 0.01-0.05 parts by weight of sodium pyrosulfite, 2-4 parts by weight of pea protein microcapsules, 0.8-1.2 parts by weight of 4D bioenzyme, 0.2-0.5 parts by weight of soothing repair agent, 0.1-0.5 parts by weight of sodium thiosulfate, 0.1-0.2 parts by weight of arginine and 0.1-0.2 parts by weight of allantoin into the mixed solution and stir; In the system of niacinamide whitening powder, sodium thiosulfate can indeed play a key role as an antioxidant. It can remove oxygen free radicals in the environment. These free radicals are one of the main factors leading to the oxidative inactivation of active ingredients such as niacinamide and ellagic acid. For example, during the storage of the product, even if protective measures such as microcapsules are taken, a small amount of oxygen may still enter the system to generate free radicals. Sodium thiosulfate can react with these free radicals and convert them into relatively stable substances, thereby protecting the chemical structure and whitening activity of niacinamide and ellagic acid. Sodium thiosulfate can also react with oxygen to consume oxygen in the system, thereby reducing the possibility of niacinamide and ellagic acid whitening agents decomposing due to oxidation. Through this reaction, the oxygen content in the environment is reduced, providing a relatively low-oxygen stable environment for niacinamide and ellagic acid, which helps to maintain their whitening effect.

[0008] During the whitening process, ingredients such as niacinamide may cause certain irritation to the skin. Sodium thiosulfate can react with some ingredients that may cause skin irritation, or reduce irritating substances caused by unstable ingredients by stabilizing the formula system. For example, when certain ingredients produce irritating by-products due to oxidation or other reactions, sodium thiosulfate can inhibit these reactions, reduce the irritation of the product to the skin, and improve the safety and tolerability of the product.

[0009] S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 130-150°C and an air outlet temperature of 60-80°C; after cooling, aseptically fill into a packaging container to obtain niacinamide whitening powder.

[0010] Preferably, in S1.1, the raw materials of the ellagic acid whitening agent are respectively as follows in terms of mass ratio: 30-35% water, 26-32% pomegranate peel extract, 18-23% glycerol, 8-12% butylene glycol, 3-7% tea extract, 1-3% ellagic acid, 0.5-1.5% 1,2-pentanediol and 0.3-0.6% glutathione.

[0011] Preferably, in S1.1, the niacinamide-ellagic acid whitening agent mixed solution is prepared by dissolving niacinamide and ellagic acid whitening agent in ethanol with a concentration of 30%-50% at a mass ratio of 1:1-3; the pea protein solution is prepared by dissolving pea protein in water to obtain a pea protein solution with a concentration of 5%-10%.

[0012] Preferably, in S1.1, the nicotinamide-ellagic acid whitening agent mixed solution is dripped into the pea protein solution at a rate of 1-2 mL / min, and stirred at a speed of 500-800 r / min for 30-40 min to form an emulsion; the emulsion is dried by a spray dryer with an inlet air temperature of 150-170°C and an outlet air temperature of 70-90°C to obtain pea protein microcapsules with a thickness of 1-5 μm.

[0013] Preferably, in S1.2, after adding butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer, the stirring speed is increased to 400-500 r / min, and the stirring time is 15-20 min.

[0014] Preferably, in S1.3, the raw materials of the 4D bio-enzyme are respectively as follows in terms of mass ratio: 55-65% glycerol, 35-40% water, 1-2% sclerotium gum, 0.5-1.5% 1,2-hexanediol, 0.5-1.0% papain and 0.5-1.0% caprylyl glycol.

[0015] Preferably, in S1.3, the raw materials of the soothing and repairing agent are respectively as follows in mass ratio: 23-26% water, 12-16% purslane extract, 12-16% glycerin, 8-12% houttuynia cordata extract, 8-12% golden chamomile extract, 5-10% opuntia cactus stem extract, 5-10% scutellaria root extract, 5-10% peony root bark extract, 0.5-1.5% 1,2-hexanediol and 0.2-0.6% parahydroxyacetophenone.

[0016] Preferably, in S1.3, the stirring speed is 300-400 rpm, and the stirring time is 15-30 min.

[0017] The present invention also provides a nicotinamide whitening powder, which is prepared according to the preparation method of the nicotinamide whitening powder.

[0018] On the other hand, the present invention also provides an application of niacinamide whitening powder, such as the application of the above-mentioned niacinamide whitening powder in the preparation of cosmetic products.

[0019] Compared with the prior art, the present invention has the following beneficial effects: 1. In the preparation method and application of the niacinamide whitening powder, pea protein microcapsules are used. Since pea protein microcapsules can effectively block light, heat and oxygen, the risk of decomposition and oxidation of niacinamide and ellagic acid is reduced, and the shelf life of the product is extended. In addition, pea protein microcapsules also improve the compatibility of ingredients, isolate sensitive ingredients from other substances, and reduce adverse reactions. Pea protein microcapsules are evenly distributed in the system, ensuring the uniform dispersion of niacinamide and ellagic acid in the whitening powder, thereby ensuring the stability of product quality and the reliability of efficacy.

[0020] 2. In the preparation method and application of the niacinamide whitening powder, sodium thiosulfate is added. Since sodium thiosulfate can effectively remove oxygen free radicals in the system and react with oxygen to reduce their content, it greatly slows down the oxidative decomposition of key ingredients such as niacinamide and ellagic acid, and stabilizes the whitening effect. In addition, sodium thiosulfate can also react with potential irritants to improve the safety of the product and reduce adverse effects on the skin, thereby comprehensively improving the quality of niacinamide whitening powder. DETAILED DESCRIPTION

[0021] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] The preparation method of 4D bio-enzyme is as follows: dissolving sclerotium gum in water to disperse and dissolve it; adding glycerol, 1,2-hexanediol, papain and caprylyl glycol, stirring at a speed of 400 rpm for 30 minutes to obtain 4D bio-enzyme.

[0023] The preparation method of ellagic acid whitening agent is as follows: glutathione is added into water to form an aqueous base liquid; glycerol, butanediol and 1,2-pentanediol are evenly mixed, and ellagic acid is added to form a mixed liquid; pomegranate peel extract, tea extract and the mixed liquid are added into the aqueous base liquid, and stirred at a speed of 400 rpm for 30 minutes to obtain the ellagic acid whitening agent.

[0024] Preparation method of a soothing repair agent: dissolve purslane extract, glycerin, houttuynia cordata extract, golden chamomile extract, opuntia cochinchinensis stem extract, scutellaria baicalensis root extract, and peony root bark extract in 1,2-hexanediol respectively; add the dissolved plant extract solution to glycerin, add water and p-hydroxyacetophenone, and stir at 400 rpm for 30 minutes to obtain a soothing repair agent.

[0025] The main active ingredients in pomegranate peel extract include tannins (ellagitannins, gallic acid, etc.), flavonoids (quercetin, rutin, etc.) and alkaloids (punicine, etc.).

[0026] The main active ingredients in tea extract include tea polyphenols, caffeine, theanine, tea polysaccharides and tea saponins.

[0027] The main active ingredients in purslane extract include flavonoids (quercetin, kaempferol, etc.), alkaloids (purslaneine, betaine, etc.), terpenes (amyrin, β-sitosterol, etc.), polysaccharides and fatty acids (linoleic acid, α-linolenic acid, etc.).

[0028] The main active ingredients in Houttuynia cordata extract include flavonoids (quercetin, hyperoside, etc.), volatile oils (houttuynia cordata, methyl nonyl ketone, etc.), organic acids (chlorogenic acid, ferulic acid, etc.), polysaccharides and alkaloids (lauramide, etc.).

[0029] The main active ingredients in golden chamomile extract include flavonoids (apigenin, luteolin, etc.), terpenes (α-bisabolol, matricaria, etc.), volatile oils (geraniol, linalool, etc.) and polysaccharides.

[0030] The main active ingredients in the stem extract of Prickly Pear Cactus include polysaccharides, flavonoids (rutin, quercetin, etc.), alkaloids (cactin, etc.), terpenes (triterpenes and steroidal terpenes, etc.), phenols (chlorogenic acid, etc.), amino acids and peptides.

[0031] The main active ingredients in Scutellaria baicalensis root extract include flavonoids (baicalin, baicalin, wogonin, etc.), volatile oils and polysaccharides.

[0032] The main active ingredients in peony root bark extract include phenols and glycosides (paeonol, peony glycoside, paeoniflorin, etc.), terpenes and their glycosides (oxidized paeoniflorin, benzoylpeoniflorin, etc.) and flavonoids (kaempferol, quercetin, etc.).

[0033] Embodiment 1: A method for preparing nicotinamide whitening powder and its application, comprising the following steps: S1.1. Weigh the following raw materials in parts by weight respectively: 80 parts by weight of water, 3 parts by weight of butylene glycol, 2 parts by weight of glycerol, 0.8 parts by weight of trehalose, 0.81 parts by weight of 4D bioenzyme, 0.2 parts by weight of p-hydroxyacetophenone, 0.2 parts by weight of panthenol, 0.2 parts by weight of niacinamide, 0.2 parts by weight of ellagic acid whitening agent, 0.2 parts by weight of 1,2-hexanediol, 0.3 parts by weight of polyol moisturizer, 0.2 parts by weight of soothing repair agent, 0.1 parts by weight of carbomer, 0.1 parts by weight of allantoin, 0.1 parts by weight of arginine, 0.05 parts by weight of hydroxyethyl cellulose, 0.01 parts by weight of sodium metabisulfite, 2 parts by weight of pea protein and 0.1 parts by weight of sodium thiosulfate; For 4D bio-enzyme, the specific mass ratio of its raw materials is: 60% glycerol, 36.1% water, 1.5% sclerotium gum, 1,2-hexanediol, 0.8% papain and 0.6% caprylyl glycol; For the ellagic acid whitening agent, the mass ratio of its raw materials is as follows: 31.5% water, 30% pomegranate peel extract, 20% glycerin, 10% butylene glycol, 5% tea extract, 2% ellagic acid, 1% 1,2-pentanediol and 0.5% glutathione; For the soothing repair agent, the mass ratio of its raw materials is as follows: 24.5% water, 15% purslane extract, 15% glycerin, 10% houttuynia cordata extract, 10% golden chamomile extract, 8% twisted cactus stem extract, 8% scutellaria root extract, 8% peony root bark extract, 1% 1,2-hexanediol and 0.5% p-hydroxyacetophenone; Nicotinamide and ellagic acid were mixed in a mass ratio of 1:1, and added to 50% ethanol to obtain a nicotinamide-ellagic acid mixed solution; pea protein was dissolved in water to obtain a pea protein solution with a concentration of 5%; the nicotinamide-ellagic acid mixed solution was added dropwise to the pea protein solution at a dropping speed of 2 mL / min, and stirred at a speed of 700 r / min for 40 min to form an emulsion; the emulsion was dried by a spray dryer with an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain pea protein microcapsules with a thickness of 5 μm; S1.2, add carbomer and hydroxyethyl cellulose to water, stir at a speed of 300 r / min for 45 minutes to form a colloidal solution; then add butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer in sequence, increase the stirring speed to 500 r / min, stir for 20 minutes to obtain a mixed solution; S1.3, add p-hydroxyacetophenone and sodium metabisulfite to the mixed solution, and continue stirring at a speed of 500r / min for 15min; under the protection of nitrogen, add pea protein microcapsules, 4D bioenzyme and soothing repair agent, and stir at a speed of 300r / min for 30min; then add sodium thiosulfate, arginine and allantoin, and continue stirring at a speed of 300r / min for 15min; S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 150°C and an air outlet temperature of 60°C; after cooling, aseptically fill the mixed solution into a clean, sterile packaging container to obtain niacinamide whitening powder.

[0034] Embodiment 2: A method for preparing nicotinamide whitening powder and its application, comprising the following steps: S1.1. Weigh the following raw materials in parts by weight respectively: 80 parts by weight of water, 3 parts by weight of butylene glycol, 2 parts by weight of glycerol, 0.8 parts by weight of trehalose, 0.81 parts by weight of 4D bioenzyme, 0.2 parts by weight of p-hydroxyacetophenone, 0.2 parts by weight of panthenol, 0.2 parts by weight of niacinamide, 0.2 parts by weight of ellagic acid whitening agent, 0.2 parts by weight of 1,2-hexanediol, 0.3 parts by weight of polyol moisturizer, 0.2 parts by weight of soothing repair agent, 0.1 parts by weight of carbomer, 0.1 parts by weight of allantoin, 0.1 parts by weight of arginine, 0.05 parts by weight of hydroxyethyl cellulose, 0.01 parts by weight of sodium metabisulfite, 2 parts by weight of pea protein and 0.1 parts by weight of sodium thiosulfate; For 4D bio-enzyme, the specific mass ratio of its raw materials is: 60% glycerol, 36.1% water, 1.5% sclerotium gum, 1,2-hexanediol, 0.8% papain and 0.6% caprylyl glycol; For the ellagic acid whitening agent, the mass ratio of its raw materials is as follows: 31.5% water, 30% pomegranate peel extract, 20% glycerin, 10% butylene glycol, 5% tea extract, 2% ellagic acid, 1% 1,2-pentanediol and 0.5% glutathione; For the soothing repair agent, the mass ratio of its raw materials is as follows: 24.5% water, 15% purslane extract, 15% glycerin, 10% houttuynia cordata extract, 10% golden chamomile extract, 8% twisted cactus stem extract, 8% scutellaria root extract, 8% peony root bark extract, 1% 1,2-hexanediol and 0.5% p-hydroxyacetophenone; Nicotinamide and ellagic acid were mixed in a mass ratio of 1:3, and added to ethanol with a concentration of 50% to obtain a nicotinamide-ellagic acid mixed solution; pea protein was dissolved in water to obtain a pea protein solution with a concentration of 5 parts by weight; the nicotinamide-ellagic acid mixed solution was added dropwise to the pea protein solution at a dropping speed of 2 mL / min, and stirred at a speed of 700 r / min for 40 minutes to form an emulsion; the emulsion was dried by a spray dryer with an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain pea protein microcapsules with a thickness of 5 μm; S1.2, add carbomer and hydroxyethyl cellulose to water, stir at a speed of 300 r / min for 45 minutes to form a colloidal solution; then add butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer in sequence, increase the stirring speed to 500 r / min, stir for 20 minutes to obtain a mixed solution; S1.3, add p-hydroxyacetophenone and sodium metabisulfite to the mixed solution, and continue stirring at a speed of 500r / min for 15min; under the protection of nitrogen, add pea protein microcapsules, 4D bioenzyme and soothing repair agent, and stir at a speed of 300r / min for 30min; then add sodium thiosulfate, arginine and allantoin, and continue stirring at a speed of 300r / min for 15min; S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 150°C and an air outlet temperature of 60°C; after cooling, aseptically fill the mixed solution into a clean, sterile packaging container to obtain niacinamide whitening powder.

[0035] Embodiment 3: A method for preparing nicotinamide whitening powder and its application, comprising the following steps: S1.1, weigh the following raw materials in parts by weight respectively: 83.3 parts by weight of water, 4 parts by weight of butanediol, 3 parts by weight of glycerol, 1 part by weight of trehalose, 1 part by weight of 4D bioenzyme, 0.5 parts by weight of p-hydroxyacetophenone, 0.5 parts by weight of panthenol, 0.5 parts by weight of niacinamide, 0.5 parts by weight of ellagic acid whitening agent, 0.5 parts by weight of 1,2-hexanediol, 0.4 parts by weight of polyol moisturizer, 0.3 parts by weight of soothing repair agent, 0.15 parts by weight of carbomer, 0.15 parts by weight of allantoin, 0.12 parts by weight of arginine, 0.06 parts by weight of hydroxyethyl cellulose, 0.02 parts by weight of sodium metabisulfite, 3.5 parts by weight of pea protein and 0.5 parts by weight of sodium thiosulfate; For 4D bio-enzyme, the specific mass ratio of its raw materials is: 60% glycerol, 36.1% water, 1.5% sclerotium gum, 1,2-hexanediol, 0.8% papain and 0.6% caprylyl glycol; For the ellagic acid whitening agent, the mass ratio of its raw materials is as follows: 31.5% water, 30% pomegranate peel extract, 20% glycerin, 10% butylene glycol, 5% tea extract, 2% ellagic acid, 1% 1,2-pentanediol and 0.5% glutathione; For the soothing repair agent, the mass ratio of its raw materials is as follows: 24.5% water, 15% purslane extract, 15% glycerin, 10% houttuynia cordata extract, 10% golden chamomile extract, 8% twisted cactus stem extract, 8% scutellaria root extract, 8% peony root bark extract, 1% 1,2-hexanediol and 0.5% p-hydroxyacetophenone; Nicotinamide and ellagic acid were mixed in a mass ratio of 1:3, and added to ethanol with a concentration of 50% to obtain a nicotinamide-ellagic acid mixed solution; pea protein was dissolved in water to obtain a pea protein solution with a concentration of 5 parts by weight; the nicotinamide-ellagic acid mixed solution was added dropwise to the pea protein solution at a dropping speed of 2 mL / min, and stirred at a speed of 700 r / min for 40 minutes to form an emulsion; the emulsion was dried by a spray dryer with an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain pea protein microcapsules with a thickness of 5 μm; S1.2, add carbomer and hydroxyethyl cellulose to water, stir at a speed of 300 r / min for 45 minutes to form a colloidal solution; then add butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer in sequence, increase the stirring speed to 500 r / min, stir for 20 minutes to obtain a mixed solution; S1.3, add p-hydroxyacetophenone and sodium metabisulfite to the mixed solution, and continue stirring at a speed of 500r / min for 15min; under the protection of nitrogen, add pea protein microcapsules, 4D bioenzyme and soothing repair agent, and stir at a speed of 300r / min for 30min; then add sodium thiosulfate, arginine and allantoin, and continue stirring at a speed of 300r / min for 15min; S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 150°C and an air outlet temperature of 60°C; after cooling, aseptically fill the mixed solution into a clean, sterile packaging container to obtain niacinamide whitening powder.

[0036] Embodiment 4: A method for preparing nicotinamide whitening powder and its application, comprising the following steps: S1.1, weigh the following raw materials in parts by weight respectively: 83.3 parts by weight of water, 4 parts by weight of butanediol, 3 parts by weight of glycerol, 1 part by weight of trehalose, 1 part by weight of 4D bioenzyme, 0.5 parts by weight of p-hydroxyacetophenone, 0.5 parts by weight of panthenol, 0.5 parts by weight of niacinamide, 0.5 parts by weight of ellagic acid whitening agent, 0.5 parts by weight of 1,2-hexanediol, 0.4 parts by weight of polyol moisturizer, 0.3 parts by weight of soothing repair agent, 0.15 parts by weight of carbomer, 0.15 parts by weight of allantoin, 0.12 parts by weight of arginine, 0.06 parts by weight of hydroxyethyl cellulose, 0.02 parts by weight of sodium metabisulfite, 3.7 parts by weight of pea protein and 0.3 parts by weight of sodium thiosulfate; For 4D bio-enzyme, the specific mass ratio of its raw materials is: 60% glycerol, 36.1% water, 1.5% sclerotium gum, 1,2-hexanediol, 0.8% papain and 0.6% caprylyl glycol; For the ellagic acid whitening agent, the mass ratio of its raw materials is as follows: 31.5% water, 30% pomegranate peel extract, 20% glycerin, 10% butylene glycol, 5% tea extract, 2% ellagic acid, 1% 1,2-pentanediol and 0.5% glutathione; For the soothing repair agent, the mass ratio of its raw materials is as follows: 24.5% water, 15% purslane extract, 15% glycerin, 10% houttuynia cordata extract, 10% golden chamomile extract, 8% twisted cactus stem extract, 8% scutellaria root extract, 8% peony root bark extract, 1% 1,2-hexanediol and 0.5% p-hydroxyacetophenone; Nicotinamide and ellagic acid were mixed in a mass ratio of 1:3, and added to ethanol with a concentration of 50% to obtain a nicotinamide-ellagic acid mixed solution; pea protein was dissolved in water to obtain a pea protein solution with a concentration of 5 parts by weight; the nicotinamide-ellagic acid mixed solution was added dropwise to the pea protein solution at a dropping speed of 2 mL / min, and stirred at a speed of 700 r / min for 40 minutes to form an emulsion; the emulsion was dried by a spray dryer with an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain pea protein microcapsules with a thickness of 5 μm; S1.2, add carbomer and hydroxyethyl cellulose to water, stir at a speed of 300 r / min for 45 minutes to form a colloidal solution; then add butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer in sequence, increase the stirring speed to 500 r / min, stir for 20 minutes to obtain a mixed solution; S1.3, add p-hydroxyacetophenone and sodium metabisulfite to the mixed solution, and continue stirring at a speed of 500r / min for 15min; under the protection of nitrogen, add pea protein microcapsules, 4D bioenzyme and soothing repair agent, and stir at a speed of 300r / min for 30min; then add sodium thiosulfate, arginine and allantoin, and continue stirring at a speed of 300r / min for 15min; S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 150°C and an air outlet temperature of 60°C; after cooling, aseptically fill the mixed solution into a clean, sterile packaging container to obtain niacinamide whitening powder.

[0037] Embodiment 5: A method for preparing niacinamide whitening powder and its application, comprising the following steps: S1.1. Weigh the following raw materials in parts by weight respectively: 83.3 parts by weight of water, 4 parts by weight of butanediol, 3 parts by weight of glycerol, 1 part by weight of trehalose, 1 part by weight of 4D bioenzyme, 0.5 parts by weight of p-hydroxyacetophenone, 0.5 parts by weight of panthenol, 0.5 parts by weight of niacinamide, 0.5 parts by weight of ellagic acid whitening agent, 0.5 parts by weight of 1,2-hexanediol, 0.4 parts by weight of polyol moisturizer, 0.3 parts by weight of soothing repair agent, 0.15 parts by weight of carbomer, 0.15 parts by weight of allantoin, 0.12 parts by weight of arginine, 0.06 parts by weight of hydroxyethyl cellulose, 0.02 parts by weight of sodium metabisulfite, 3.6 parts by weight of pea protein and 0.4 parts by weight of sodium thiosulfate; For 4D bio-enzyme, the specific mass ratio of its raw materials is: 60% glycerol, 36.1% water, 1.5% sclerotium gum, 1,2-hexanediol, 0.8% papain and 0.6% caprylyl glycol; For the ellagic acid whitening agent, the mass ratio of its raw materials is as follows: 31.5% water, 30% pomegranate peel extract, 20% glycerin, 10% butylene glycol, 5% tea extract, 2% ellagic acid, 1% 1,2-pentanediol and 0.5% glutathione; For the soothing repair agent, the mass ratio of its raw materials is as follows: 24.5% water, 15% purslane extract, 15% glycerin, 10% houttuynia cordata extract, 10% golden chamomile extract, 8% twisted cactus stem extract, 8% scutellaria root extract, 8% peony root bark extract, 1% 1,2-hexanediol and 0.5% p-hydroxyacetophenone; Nicotinamide and ellagic acid were mixed in a mass ratio of 1:3, and added to ethanol with a concentration of 50% to obtain a nicotinamide-ellagic acid mixed solution; pea protein was dissolved in water to obtain a pea protein solution with a concentration of 5 parts by weight; the nicotinamide-ellagic acid mixed solution was added dropwise to the pea protein solution at a dropping speed of 2 mL / min, and stirred at a speed of 700 r / min for 40 minutes to form an emulsion; the emulsion was dried by a spray dryer with an inlet air temperature of 160°C and an outlet air temperature of 80°C to obtain pea protein microcapsules with a thickness of 5 μm; S1.2, add carbomer and hydroxyethyl cellulose to water, stir at a speed of 300 r / min for 45 minutes to form a colloidal solution; then add butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer in sequence, increase the stirring speed to 500 r / min, stir for 20 minutes to obtain a mixed solution; S1.3, add p-hydroxyacetophenone and sodium metabisulfite to the mixed solution, and continue stirring at a speed of 500r / min for 15min; under the protection of nitrogen, add pea protein microcapsules, 4D bioenzyme and soothing repair agent, and stir at a speed of 300r / min for 30min; then add sodium thiosulfate, arginine and allantoin, and continue stirring at a speed of 300r / min for 15min; S1.4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 150°C and an air outlet temperature of 60°C; after cooling, aseptically fill the mixed solution into a clean, sterile packaging container to obtain niacinamide whitening powder.

[0038] Comparative Example 1 The method of Example 3 is adopted to remove pea protein in the preparation method of niacinamide whitening powder.

[0039] Comparative Example 2 The method of Example 3 is adopted to remove sodium thiosulfate in the preparation method of niacinamide whitening powder.

[0040] The nicotinamide whitening powder prepared by the present invention, wherein the performance index inspection items and inspection standards of the nicotinamide whitening powder are as follows: Before using the product, select the face as a test area and make sure there is no obvious pigmentation or damage in the area; use a colorimeter to measure and record the initial Lab value. After using the product continuously for 4-8 weeks according to the prescribed frequency and method, measure the Lab value of the same area again and calculate the ΔE value (total color difference); a higher ΔE value indicates that the product can significantly reduce the yellow and red tones of the skin after use, making the skin tone more even and bright.

[0041] According to the standard T / SHRH 006-2018 "Cosmetics - Free Radical (DPPH) Scavenging Experimental Method", the experimental method of this national standard was adopted to prepare a DPPH solution with a concentration of 0.04 mg / mL, take an appropriate amount of sample solution with different concentration gradients, add an equal volume of DPPH solution, mix evenly, place in a dark place away from light for 30 minutes, use a spectrophotometer to measure the absorbance at a wavelength of 517 nm, and calculate the DPPH free radical scavenging rate based on the change in absorbance; a high DPPH free radical scavenging rate indicates that the product has a strong antioxidant ability, can effectively neutralize free radicals, and prevent cell damage and aging.

[0042] According to the above standards, the nicotinamide whitening powder prepared in the above Examples 1-5 and Comparative Examples 1-2 was tested, and the obtained data are shown in Table 1: Table 1 Performance data of nicotinamide whitening powder of Examples 1-5 and Comparative Examples 1-2

[0043] It can be seen from Table 1 that the nicotinamide whitening powder prepared in Examples 1-5 has a significantly high ΔE value and a high DPPH free radical scavenging rate.

[0044] Taking Example 3 as the optimal example and combining it with Comparative Example 1, it can be seen that in the preparation method of niacinamide whitening powder, when pea protein is removed, the ΔE value and DPPH free radical scavenging rate of niacinamide whitening powder are significantly reduced; Pea protein plays a protective role in niacinamide whitening powder, and can effectively prevent the two whitening ingredients, niacinamide and ellagic acid, from being affected by external factors such as light, heat and oxygen; ellagic acid is prone to oxidation reaction in an aerobic environment, and its oxidation products may cause changes in product color, while niacinamide may produce colored substances after decomposition, affecting the color stability of the product; therefore, the presence of pea protein helps to maintain the structural and functional integrity of these ingredients, thereby maintaining the color stability of the product and the effectiveness of the active ingredients; the application of pea protein microencapsulation technology makes the active ingredients more evenly distributed in the product, avoiding local concentrations that are too high or too low. Without pea protein, this uniformity may be affected, resulting in inconsistent product appearance color and increased color differences, thereby reducing the ΔE value.

[0045] Niacinamide and ellagic acid are the main free radical scavenging ingredients in whitening powder; the presence of pea protein can protect them from external interference and maintain their ability to scavenge free radicals. After removing the pea protein, niacinamide and ellagic acid are more easily oxidized or decomposed, and their chemical structure is destroyed, resulting in a decrease in their ability to scavenge DPPH free radicals; the phenolic hydroxyl group of ellagic acid is the key structural part for scavenging free radicals. After oxidation or decomposition, the number of phenolic hydroxyl groups decreases or the activity decreases, which reduces the scavenging rate of DPPH free radicals.

[0046] Example 3 is the best example, and combined with Comparative Example 2, it can be seen that in the preparation method of niacinamide whitening powder, when sodium thiosulfate is removed, the ΔE value and DPPH free radical scavenging rate of niacinamide whitening powder are significantly reduced; Sodium thiosulfate can scavenge free radicals in the system, thereby protecting other ingredients in the formula from oxidative damage. When sodium thiosulfate is removed, the free radical scavenging ability decreases significantly, resulting in a weakened overall effectiveness of the antioxidant system. Ingredients such as niacinamide and ellagic acid are more susceptible to oxygen attack and oxidation reactions in the absence of sodium thiosulfate. Ellagic acid contains multiple phenolic hydroxyl groups, which are easily oxidized under aerobic conditions to produce colored substances such as quinones, and niacinamide may also produce colored degradation products during the oxidation process. These oxidation reactions will cause the product color to change. Compared with products where sodium thiosulfate has not been removed, the ΔE value (color difference value) is significantly reduced.

[0047] Sodium thiosulfate not only helps maintain the stability of the formulation system, but also reacts with the free radical intermediates generated by niacinamide or ellagic acid, allowing them to regenerate and continue to exert their antioxidant effects. This synergistic effect is destroyed after the removal of sodium thiosulfate, resulting in a significant decrease in the DPPH free radical scavenging rate.

[0048] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A method for preparing nicotinamide whitening powder, characterized in that: The following steps are involved: S1.1, adding the nicotinamide-ellagic acid whitening agent mixed solution dropwise to the pea protein solution, and forming pea protein microcapsules by spray drying; S1.2, add 0.1-0.2 parts by weight of carbomer and 0.05-0.1 parts by weight of hydroxyethyl cellulose to 80-85 parts by weight of water, and stir at a speed of 200-300 r / min for 30-60 min to form a colloidal solution; then add 3-5 parts by weight of butylene glycol, 2-4 parts by weight of glycerol, 0.8-1.2 parts by weight of trehalose, 0.2-0.6 parts by weight of panthenol, 0.2-0.6 parts by weight of 1,2-hexanediol and 0.3-0.5 parts by weight of a polyol moisturizer in sequence, and stir to obtain a mixed solution; S1.3, add 0.2-0.6 parts by weight of p-hydroxyacetophenone, 0.01-0.05 parts by weight of sodium pyrosulfite, 2-4 parts by weight of pea protein microcapsules, 0.8-1.2 parts by weight of 4D bioenzyme, 0.2-0.5 parts by weight of soothing repair agent, 0.1-0.5 parts by weight of sodium thiosulfate, 0.1-0.2 parts by weight of arginine and 0.1-0.2 parts by weight of allantoin into the mixed solution and stir; S1.

4. Dry the mixed solution in S1.3 by a spray dryer with an air inlet temperature of 130-150°C and an air outlet temperature of 60-80°C; after cooling, aseptically fill into a packaging container to obtain niacinamide whitening powder.

2. The method for preparing nicotinamide whitening powder according to claim 1, characterized in that: In S1.1, the raw materials of the ellagic acid whitening agent are respectively as follows in terms of mass ratio: 30-35% water, 26-32% pomegranate peel extract, 18-23% glycerol, 8-12% butylene glycol, 3-7% tea extract, 1-3% ellagic acid, 0.5-1.5% 1,2-pentanediol and 0.3-0.6% glutathione.

3. The method for preparing nicotinamide whitening powder according to claim 2, characterized in that: In S1.1, the nicotinamide-ellagic acid whitening agent mixed solution is obtained by dissolving nicotinamide and ellagic acid whitening agent in ethanol with a concentration of 30%-50% in a mass ratio of 1:1-3; The pea protein solution is prepared by dissolving pea protein in water to obtain a pea protein solution with a concentration of 5%-10%.

4. The method for preparing nicotinamide whitening powder according to claim 3, characterized in that: In S1.1, the nicotinamide-ellagic acid whitening agent mixed solution is dripped into the pea protein solution at a rate of 1-2 mL / min, and stirred at a speed of 500-800 r / min for 30-40 min to form an emulsion; the emulsion is dried by a spray dryer with an inlet air temperature of 150-170° C. and an outlet air temperature of 70-90° C. to obtain pea protein microcapsules with a thickness of 1-5 μm.

5. The method for preparing nicotinamide whitening powder according to claim 1, characterized in that: In S1.2, after adding butylene glycol, glycerol, trehalose, panthenol, 1,2-hexanediol and polyol moisturizer, the stirring speed is increased to 400-500 r / min, and the stirring time is 15-20 min.

6. The method for preparing nicotinamide whitening powder according to claim 1, characterized in that: In S1.3, the raw materials of the 4D bio-enzyme are respectively: 55-65% glycerol, 35-40% water, 1-2% sclerotium gum, 0.5-1.5% 1,2-hexanediol, 0.5-1.0% papain and 0.5-1.0% caprylyl glycol in mass ratio.

7. The method for preparing nicotinamide whitening powder according to claim 1, characterized in that: In S1.3, the raw materials of the soothing and repairing agent are respectively as follows in terms of mass ratio: 23-26% water, 12-16% purslane extract, 12-16% glycerin, 8-12% houttuynia cordata extract, 8-12% golden chamomile extract, 5-10% opuntia cactus stem extract, 5-10% scutellaria root extract, 5-10% peony root bark extract, 0.5-1.5% 1,2-hexanediol and 0.2-0.6% parahydroxyacetophenone.

8. The method for preparing nicotinamide whitening powder according to claim 1, characterized in that: In S1.3, the stirring speed is 300-400 rpm, and the stirring time is 15-30 min.

9. A niacinamide whitening powder, characterized in that: The nicotinamide whitening powder is prepared according to the preparation method of any one of claims 1 to 8.

10. An application of niacinamide whitening powder, characterized in that: Use of the niacinamide whitening powder as claimed in claim 9 in the preparation of cosmetic products.

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