Mild cosmetic for preventing photoaging and preparation method thereof

Abstract

The invention discloses a mild cosmetic for preventing photoaging and a preparation method thereof, and relates to the technical field of cosmetics. According to the mild cosmetic disclosed by the invention, the antioxidant, the humectant and the anti-inflammatory component are reasonably proportioned, so that the mild cosmetic can effectively resist the damage of ultraviolet rays and blue light to skin and slow down the photoaging process. Meanwhile, mild components are selected, so that the product is suitable for sensitive skin, the irritation is reduced, and the comfort of a user is improved. The cosmetic has a remarkable moisturizing effect, and can keep moisture balance of skin and enhance a skin barrier function while resisting light aging. In addition, the anti-inflammatory components are added, so that the inflammatory reaction caused by illumination is relieved, and the skin health is further protected.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a mild cosmetic for preventing photoaging and a preparation method thereof. Background Art

[0002] As people age, their entire body will gradually age, and this aging is particularly evident in appearance, such as graying hair and sagging skin that loses its luster. Skin aging is generally divided into physiological aging and photoaging. Physiological aging is largely related to oxidation, and the effect of oxidative free radicals makes the human body age. Photoaging is mainly caused by long-term radiation from ultraviolet rays (especially ultraviolet A and ultraviolet B), which not only causes the generation of peroxides in the body, but also affects the activity of tyrosinase in the skin. Tyrosinase can catalyze the synthesis of tyrosine into dopa, dopaquinone, dopachrome, 5,6-dihydroxyindole, indole-5,6-quinone, and then form melanin. Melanin is then transferred from cells to the basal layer and precipitated therein. As melanin is continuously generated, the skin continues to darken. In addition, the irradiation of ultraviolet rays can also cause the loss of collagen in the skin and the excessive proliferation of the stratum corneum, thereby causing the skin elasticity to decrease and wrinkles to appear. Summary of the invention

[0003] The object of the present invention is to provide a mild cosmetic for preventing photoaging and a preparation method thereof, so as to solve the problems existing in the prior art.

[0004] In order to solve the above technical problems, the present invention provides the following technical solutions: a mild cosmetic for preventing photoaging, comprising verbena extract, hydrolyzed sodium hyaluronate, ceramide, daisy flower extract, high-purity bamboo leaf carbon glycoside flavonoids, camellia extract, antioxidants, aloe extract, and sesame extract.

[0005] Furthermore, the content of the verbena extract is 5 to 10 parts by weight, and the content of the sesame extract is 1 to 10 parts by weight.

[0006] Furthermore, the content of the hydrolyzed sodium hyaluronate is 15 to 25 parts by weight, and the content of ceramide is 10 to 20 parts by weight.

[0007] Furthermore, the content of the daisy flower extract is 1 to 5 parts by weight, and the content of the aloe vera extract is 1 to 5 parts by weight.

[0008] Furthermore, the content of the high-purity bamboo leaf carbonyl glycoside flavonoids is 10 to 20 parts by weight.

[0009] Furthermore, the content of the camellia extract is 10 to 15 parts by weight.

[0010] Furthermore, the antioxidant is vitamin C, vitamin E or a derivative thereof, and the content thereof is 1 to 5 parts by weight.

[0011] Furthermore, the mild cosmetic for preventing photoaging also comprises a matrix, wherein the matrix is ​​an oil-in-water emulsion, wherein the vegetable oil is selected from one or more of jojoba oil, squalane, and olive oil, and the emulsifier is selected from one or more of cetearyl alcohol and glyceryl stearate.

[0012] Furthermore, the mild cosmetic for preventing photoaging also contains a thickener selected from one or more of xanthan gum and carbomer.

[0013] Furthermore, the mild cosmetic for preventing photoaging comprises the following preparation steps:

[0014] (1) mixing verbena extract, hydrolyzed sodium hyaluronate, ceramide, daisy flower extract, high-purity bamboo leaf carbon glycoside flavonoids, camellia extract, antioxidants, aloe extract and vegetable oil to form an oil phase;

[0015] (2) mixing water and an emulsifier and heating them to form an aqueous phase;

[0016] (3) mixing the water phase and the oil phase and stirring to form an emulsion;

[0017] (4) cooling to room temperature, adding a thickener, and stirring evenly to obtain the cosmetic.

[0018] Compared with the prior art, the beneficial effects achieved by the present invention are:

[0019] The mild cosmetics of the present invention can effectively resist the damage of ultraviolet rays and blue light to the skin and slow down the photoaging process by rationally mixing antioxidants, moisturizers and anti-inflammatory ingredients. At the same time, mild ingredients are selected to ensure that the product is suitable for sensitive skin, reduce irritation, and improve the comfort of users. The moisturizing effect of the cosmetics is significant, and it can maintain the moisture balance of the skin and enhance the skin barrier function while resisting photoaging. In addition, the addition of anti-inflammatory ingredients helps to alleviate the inflammatory response caused by light exposure and further protects skin health.

[0020] High-purity bamboo leaf carbon glycoside flavonoids and camellia extract can effectively resist the damage of ultraviolet rays and blue light and prevent skin photoaging. Daisy flower extract has anti-inflammatory and soothing effects, reducing skin redness and irritation. Rosemary leaf extract ensures the mildness of the composition, does not cause irritation to the skin, and is suitable for all skin types. The cosmetics of the present invention use natural plant extracts as the main active ingredients and avoid the use of irritating chemical ingredients such as alcohol, flavors, etc. The selected plant extracts have good skin tolerance and can effectively reduce the risk of skin allergies and irritation. In addition, the cosmetics of the present invention also add verbena extract, hydrolyzed sodium hyaluronate and ceramide to enhance the hydration of the skin, attract and bind moisture in the air, maintain the moisture content of the skin, and make the skin plump and firm. Therefore, the cosmetics of the present invention are mild and non-irritating, and are suitable for all skin types, including sensitive skin.

[0021] Through the above combination and preparation method, the present invention provides a comprehensive and efficient mild cosmetic for preventing photoaging, which can meet the diverse needs of modern people for skin care products. The preparation method is simple and easy, adopts a conventional emulsification process, and is easy to industrialize. DETAILED DESCRIPTION

[0022] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Example 1

[0024] (1) 5 parts by weight of verbena extract, 1 part by weight of sesame extract, 15 parts by weight of hydrolyzed sodium hyaluronate, 10 parts by weight of ceramide, 1 part by weight of daisy flower extract, 1 part by weight of aloe extract, 10 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 10 parts by weight of camellia extract, and 1 part by weight of vitamin C are mixed to obtain an active ingredient;

[0025] (2) mixing the active ingredient and jojoba oil in a mass ratio of 0.1:1 to obtain an oil phase;

[0026] (3) weighing cetearyl alcohol and distilled water in a mass ratio of 0.08:1, heating to 75° C., and mixing well to obtain an aqueous phase;

[0027] (4) Weigh the oil phase and the water phase in a mass ratio of 0.1:1, mix and stir to obtain a mixed solution, homogenize the mixed solution by a high-pressure homogenizer for 5 times under a pressure of 70150 MPa and a temperature of 75°C, and add xanthan gum in an amount of 0.05 times the mass of the mixed solution to obtain the obtained cosmetic.

[0028] Example 2

[0029] (1) 5.7 parts by weight of verbena extract, 2.2 parts by weight of sesame extract, 16.4 parts by weight of hydrolyzed sodium hyaluronate, 11.4 parts by weight of ceramide, 1.5 parts by weight of daisy flower extract, 1.5 parts by weight of aloe extract, 11 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 10.7 parts by weight of camellia extract, and 1.7 parts by weight of vitamin C are mixed to obtain an active ingredient;

[0030] (2) mixing the active ingredient and jojoba oil in a mass ratio of 0.128:1 to obtain an oil phase;

[0031] (3) weighing cetearyl alcohol and distilled water in a mass ratio of 0.09:1, heating to 75° C., and mixing well to obtain an aqueous phase;

[0032] (4) Weigh the oil phase and the water phase at a mass ratio of 0.14:1, mix and stir to obtain a mixed solution, homogenize the mixed solution by a high-pressure homogenizer for 5 times under the conditions of a pressure of 80 MPa and a temperature of 75° C., and add xanthan gum in an amount of 0.05 times the mass of the mixed solution to obtain the obtained cosmetic.

[0033] Example 3

[0034] (1) 6.4 parts by weight of verbena extract, 3.5 parts by weight of sesame extract, 17.8 parts by weight of hydrolyzed sodium hyaluronate, 12.8 parts by weight of ceramide, 2.1 parts by weight of daisy flower extract, 2 parts by weight of aloe extract, 12.5 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 11.4 parts by weight of camellia extract, and 2.1 parts by weight of vitamin C were mixed to obtain an active ingredient;

[0035] (2) mixing the active ingredient and jojoba oil in a mass ratio of 0.157:1 to obtain an oil phase;

[0036] (3) weighing cetearyl alcohol and distilled water in a mass ratio of 0.114:1, heating to 75° C., and mixing well to obtain an aqueous phase;

[0037] (4) Weigh the oil phase and the water phase at a mass ratio of 0.18:1, mix and stir to obtain a mixed solution, homogenize the mixed solution by a high-pressure homogenizer for 5 times under the conditions of a pressure of 70 MPa and a temperature of 75° C., and add xanthan gum in an amount of 0.05 times the mass of the mixed solution to obtain the obtained cosmetic.

[0038] Example 4

[0039] (1) 7.1 parts by weight of verbena extract, 4.8 parts by weight of sesame extract, 19.2 parts by weight of hydrolyzed sodium hyaluronate, 14.2 parts by weight of ceramide, 2.7 parts by weight of daisy flower extract, 2.5 parts by weight of aloe extract, 14 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 12.1 parts by weight of camellia extract, and 2.7 parts by weight of vitamin C are mixed to obtain an active ingredient;

[0040] (2) mixing the active ingredient and squalane in a mass ratio of 0.185:1 to obtain an oil phase;

[0041] (3) weighing cetearyl alcohol and distilled water in a mass ratio of 0.131:1, heating to 80° C., and mixing well to obtain an aqueous phase;

[0042] (4) Weigh the oil phase and the water phase in a mass ratio of 0.228:1, mix and stir to obtain a mixed solution, pass the mixed solution through a high-pressure homogenizer for 10 cycles at a pressure of 100 MPa and a temperature of 80° C., and add xanthan gum in an amount of 0.07 times the mass of the mixed solution to obtain the obtained cosmetic.

[0043] Example 5

[0044] (1) 7.8 parts by weight of verbena extract, 6.1 parts by weight of sesame extract, 20.7 parts by weight of hydrolyzed sodium hyaluronate, 15.7 parts by weight of ceramide, 3.2 parts by weight of daisy flower extract, 3 parts by weight of aloe extract, 15.5 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 12.8 parts by weight of camellia extract, and 3 parts by weight of vitamin C are mixed to obtain an active ingredient;

[0045] (2) mixing the active ingredient and squalane in a mass ratio of 0.214:1 to obtain an oil phase;

[0046] (3) weighing glyceryl stearate and distilled water in a mass ratio of 0.148:1, heating to 80° C., and mixing well to obtain an aqueous phase;

[0047] (4) Weigh the oil phase and the water phase at a mass ratio of 0.27:1, mix and stir to obtain a mixed solution, homogenize the mixed solution by circulating it through a high-pressure homogenizer for 10 times under the conditions of a pressure of 100 MPa and a temperature of 85° C., and add carbomer in an amount of 0.07 times the mass of the mixed solution to obtain the obtained cosmetic.

[0048] Example 6

[0049] (1) 12.1 parts by weight of verbena extract, 7.4 parts by weight of sesame extract, 22.1 parts by weight of hydrolyzed sodium hyaluronate, 17 parts by weight of ceramide, 3.8 parts by weight of daisy flower extract, 3.4 parts by weight of aloe extract, 17.2 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 13.4 parts by weight of camellia extract, and 3.5 parts by weight of vitamin C are mixed to obtain an active ingredient;

[0050] (2) mixing the active ingredient and olive oil in a mass ratio of 0.242:1 to obtain an oil phase;

[0051] (3) weighing glyceryl stearate and distilled water in a mass ratio of 0.165:1, heating to 85° C., and mixing well to obtain an aqueous phase;

[0052] (4) Weighing an oil phase and an aqueous phase at a mass ratio of 0.314:1, mixing and stirring to obtain a mixed solution, homogenizing the mixed solution by circulating through a high-pressure homogenizer for 15 times under the conditions of a pressure of 150 MPa and a temperature of 90° C., and adding carbomer in an amount 0.1 times the mass of the mixed solution to obtain the obtained cosmetic.

[0053] Example 7

[0054] (1) 10 parts by weight of verbena extract, 10 parts by weight of sesame extract, 25 parts by weight of hydrolyzed sodium hyaluronate, 20 parts by weight of ceramide, 5 parts by weight of daisy flower extract, 5 parts by weight of aloe extract, 20 parts by weight of high-purity bamboo leaf carbon glycoside flavonoids, 15 parts by weight of camellia extract, and 5 parts by weight of vitamin C are mixed to obtain an active ingredient;

[0055] (2) mixing the active ingredient and olive oil in a mass ratio of 0.3:1 to obtain an oil phase;

[0056] (3) weighing glyceryl stearate and distilled water in a mass ratio of 0.2:1, heating to 85° C., and mixing well to obtain an aqueous phase;

[0057] (4) Weigh the oil phase and the water phase in a mass ratio of 0.4:1, mix and stir to obtain a mixed solution, pass the mixed solution through a high-pressure homogenizer for 15 cycles at a pressure of 150 MPa and a temperature of 90° C., and add carbomer in an amount 0.1 times the mass of the mixed solution to obtain the obtained cosmetic.

[0058] Test Example 1: Safety Test Experiment

[0059] Refer to SN / T2329-2009 "Cosmetic Eye Irritation / Chicken Embryo Chorioallantoic Membrane Test" to conduct eye irritation test, i.e. safety test, on the product.

[0060] Experimental method: Fertilized chicken embryos less than 7 days old were used and incubated in an incubator at 37.6±0.5℃ and 50%-70% humidity for 9 days.

[0061] CAM preparation: Candle the egg, mark the location of the air chamber on the eggshell surface, peel off the marked eggshell with tweezers to expose the white egg membrane, and be careful not to damage the integrity of the egg membrane. Add 0.5mL 0.9% NaCl solution to fully moisten the egg membrane, gently absorb the surface liquid with a paper towel, and carefully remove the inner membrane with tweezers to ensure that the vascular membrane is not damaged.

[0062] Reaction endpoint method: Take 0.3 mL of the non-transparent test substance and evenly drop or apply it on the surface of the CAM. After 3 minutes, use 0.9% NaCl solution to wash away the test substance and observe the degree of change of each toxic effect of the CAM.

[0063] Endpoint score method (endpointscore ES): For tests conducted using the reaction endpoint method, the endpoint score (ES) should be calculated, and the result should be rounded to two decimal places. The score for each chicken embryo = the sum of the bleeding, coagulation and vascular melting observed for each chicken embryo, ES = the mathematical sum of the scores of 6 chicken embryos. Classify the eye irritation of the test substance according to Table 1 based on the ES value.

[0064] Table 1 Criteria for determining the results of the reaction endpoint method

[0065] Stimulus score ES≤12 12<ES<16 ES≥16 Irritation classification No / mild irritation Moderate irritation Strong irritation

[0066] The test results are shown in Table 2. Examples 1 to 7 are non-irritating.

[0067] Table 2 Statistics of irritation test results

[0068]

[0069]

[0070] Test Example 2: Anti-inflammatory Test Experiment

[0071] 45 volunteers with severe facial acne were selected and divided into three groups, each with 15 people. The emulsions obtained in Examples 1-3 were applied to the facial acne symptoms of the three groups of volunteers, and the volunteers generally felt comfortable, the acne became lighter, and no acne marks were left. After a period of continuous use, the acne condition was significantly alleviated.

[0072] The efficacy of the lotions prepared in Examples 1 to 7 was evaluated by trial experience. A total of 210 patients with facial acne aged 25-35 were selected as trial subjects using a public opinion survey scoring method. The subjects were randomly divided into seven groups and the lotions prepared in Examples 1 to 7 were used respectively. The lotions were used twice a day for two months. The total score of each effect was 5 points: 5 points was the highest score, indicating very good and very satisfactory; 4 points was relatively good; 3 points was acceptable; and less than 3 points was not good and unacceptable. The following is the average score of each item. The results are shown in Table 3:

[0073] Table 3 Comprehensive effect investigation

[0074] Moisturizing Nourishing Anti-inflammatory effect Color fragrance Example 1 4.5 4.4 4.6 4.8 4.7 Example 2 4.6 4.5 4.7 4.8 4.7 Example 3 4.7 4.5 4.7 4.8 4.7 Example 4 4.8 4.8 4.8 4.9 4.9 Example 5 4.9 4.9 4.9 4.9 4.8 Example 6 5 4.9 4.9 4.9 4.8 Example 7 4.9 4.8 4.9 4.9 4.8

[0075] Test Example 3: Anti-light aging test

[0076] 150 mg of compositions 1 to 7 and the compositions of comparative examples 1 to 6 were respectively diluted with 5 mL of 50% ethanol, and the transmittance of each sample in each wavelength range was measured using a spectrophotometer to determine the sunscreen performance of the sample. 50% ethanol was used as a blank, and a 1CM cuvette was used to measure the average transmittance of the sample at 200, 240 nm and 280 nm in the UV-C zone, 280 nm and 320 nm in the UV-B zone, and 320, 360 and 400 nm in the UV-A zone.

[0077] The test results of the ultraviolet absorption rate of Examples 1 to 7 are specifically shown in Table 4.

[0078] Table 4 Absorption rate of Examples 1 to 7 to ultraviolet rays of different wavelengths (%)

[0079] 200nm 240nm 280nm 320nm 360nm 400nm Example 1 44.2 48.6 62.7 70.1 80.7 85.8 Example 2 46.7 50.8 63.8 72.5 81.6 87.4 Example 3 48.4 53.7 66.2 77.1 83.7 88.6 Example 4 50.1 54.8 67.1 77.9 84.1 89.6 Example 5 51.7 55.4 68.3 79.3 85.5 90.5 Example 6 52.6 56.3 69.1 82.6 87.7 94.3 Example 7 53.2 56.8 72.3 84.9 90.7 98.0

[0080] From the experimental data comparison of the embodiments, it can be found that the mild cosmetics of the present invention can effectively resist the damage of ultraviolet rays and blue light to the skin and slow down the photoaging process by rationally matching antioxidants, moisturizers and anti-inflammatory ingredients. At the same time, mild ingredients are selected to ensure that the product is suitable for sensitive skin, reduce irritation, and improve the comfort of users. The moisturizing effect of the cosmetics is significant, and it can maintain the moisture balance of the skin and enhance the skin barrier function while resisting photoaging. In addition, the addition of anti-inflammatory ingredients helps to alleviate the inflammatory response caused by light exposure and further protect skin health.

[0081] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations within the meaning and scope of the equivalent elements of the claims be included in the invention. Any marking in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A mild cosmetic for preventing photoaging, characterized in that: Including verbena extract, hydrolyzed sodium hyaluronate, ceramide, daisy flower extract, high-purity bamboo leaf carbon glycoside flavonoids, camellia extract, antioxidants, aloe extract, and sesame extract.

2. A mild cosmetic for preventing photoaging according to claim 1, characterized in that: The content of the verbena extract is 5 to 10 parts by weight, and the content of the sesame extract is 1 to 10 parts by weight.

3. A mild cosmetic for preventing photoaging according to claim 1, characterized in that: The content of the hydrolyzed sodium hyaluronate is 15 to 25 parts by weight, and the content of ceramide is 10 to 20 parts by weight.

4. A mild cosmetic for preventing photoaging according to claim 1, characterized in that: The content of the daisy flower extract is 1 to 5 parts by weight, and the content of the aloe vera extract is 1 to 5 parts by weight.

5. The mild cosmetic for preventing photoaging according to claim 1, characterized in that: The content of the high-purity bamboo leaf carbonyl glycoside flavonoids is 10 to 20 parts by weight.

6. A mild cosmetic for preventing photoaging according to claim 1, characterized in that: The content of the camellia extract is 10 to 15 parts by weight.

7. The mild cosmetic for preventing photoaging according to claim 1, characterized in that: The antioxidant is vitamin C, vitamin E or a derivative thereof, and the content thereof is 1 to 5 parts by weight.

8. The mild cosmetic for preventing photoaging according to claim 1, characterized in that: The mild cosmetic for preventing photoaging further comprises a matrix, wherein the matrix is ​​an oil-in-water emulsion, wherein the vegetable oil is selected from one or more of jojoba oil, squalane, and olive oil, and the emulsifier is selected from one or more of cetearyl alcohol and glyceryl stearate.

9. The mild cosmetic for preventing photoaging according to claim 1, characterized in that: The mild cosmetic for preventing photoaging further comprises a thickener selected from one or more of xanthan gum and carbomer.

10. A method for preparing the mild cosmetic for preventing photoaging according to claims 1 to 9, characterized in that: The method comprises the following preparation steps: (1) mixing verbena extract, hydrolyzed sodium hyaluronate, ceramide, daisy flower extract, high-purity bamboo leaf carbon glycoside flavonoids, camellia extract, antioxidants, aloe extract and vegetable oil to form an oil phase; (2) mixing water and an emulsifier and heating them to form an aqueous phase; (3) mixing the water phase and the oil phase and stirring to form an emulsion; (4) cooling to room temperature, adding a thickener, and stirring evenly to obtain the cosmetic.

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