Angelica sinensis egg-promoting traditional Chinese medicine composition for simplifying artificial cycle sequential therapy for multiple gynecological diseases

Abstract

The invention provides a group of Chinese angelica egg-promoting traditional Chinese medicine composition for simplifying artificial cycle sequential therapy for various gynecological diseases, which is prepared from various traditional Chinese medicine decoction piece raw materials such as Chinese angelica, rhizoma cyperi, semen cuscutae and the like, and provides a specific raw material weight part range and a preferable formula. The preparation method of the traditional Chinese medicine composition comprises the following steps: cleaning the raw materials, drying, crushing, decocting twice, filtering, combining extracting solutions, concentrating, freeze-drying and the like. In addition, the invention also relates to a pharmaceutical preparation containing the traditional Chinese medicine composition, the dosage form of the pharmaceutical preparation can be oral decoction, pills, capsules or granules, and the pharmaceutical preparation can contain pharmaceutically acceptable auxiliary materials. Particularly, when the preparation is a decoction, the preparation can be prepared by dissolving a therapeutic amount of medicine powder in water. The traditional Chinese medicine composition can be used for preparing medicines for treating infertility, irregular menstruation or dysmenorrhea, and has a wide application prospect.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine compositions, and specifically discloses a group of angelica ovulation-stimulating traditional Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases. Background Art

[0002] In the field of gynecological treatment, the choice of drugs has always been an important and complex issue. With the rapid development of modern medicine, chemical drugs have been widely used in clinical practice due to their rapid and effective characteristics. However, while treating gynecological diseases, chemical drugs also bring a series of side effects that cannot be ignored. These side effects may not only affect the patient's physical health, but also reduce the patient's quality of life and even cause the patient to resist treatment.

[0003] The side effects of chemical drugs are mainly manifested in damage to liver and kidney function, interference with the endocrine system, and irritation to the gastrointestinal tract. Long-term use of chemical drugs may lead to abnormal liver and kidney function, endocrine disorders, and gastrointestinal reactions such as nausea, vomiting, and diarrhea. These side effects not only increase the treatment burden of patients, but may also affect the treatment effect and recovery process of patients.

[0004] In contrast, Chinese medicine has gradually attracted attention in the treatment of gynecological diseases due to its natural and mild characteristics. Chinese medicine adjusts the balance of yin and yang in the human body and harmonizes qi and blood, thereby achieving the purpose of treating diseases. However, although Chinese medicine has certain advantages in the treatment of gynecological diseases, the uncertainty of its drug effects is also a problem that cannot be ignored.

[0005] Traditional Chinese medicine prescriptions often contain a variety of medicinal materials, and the dosage and ratio of each medicinal material need to be precisely controlled. This complexity not only increases the difficulty and cost of preparation, but also makes it difficult to accurately evaluate the efficacy of Chinese medicine. At the same time, the efficacy of Chinese medicine is often affected by many factors, such as the source of the medicinal materials, the processing method, the decoction time, etc., which makes the efficacy of Chinese medicine uncertain.

[0006] In order to overcome the side effects of chemical drugs and the unclear effects of traditional Chinese medicine, there is an urgent need for a safe and effective treatment plan for gynecological diseases in clinical practice. Summary of the invention

[0007] To solve the above problems, we have disclosed a set of Chinese medicine compositions for ovulation promotion using Angelica sinensis for simplified artificial cycle sequential therapy for a variety of gynecological diseases. They were developed by nationally renowned Chinese medicine chief physician Lü Shaoguang, who has accumulated 50 years of experience in Chinese gynecology and has added, subtracted and optimized traditional Chinese medicine artificial cycle sequential therapy.

[0008] The present invention includes the following specific technical solutions:

[0009] A set of Chinese medicine compositions for promoting ovulation with angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases, which are made from the following Chinese medicine decoction pieces: angelica sinensis, cyperus rotundus, dodder seed, fenugreek, Morinda officinalis, cornus officinalis, mulberry, Eclipta prostrata, and dendrobium.

[0010] Furthermore, the above-mentioned set of Angelica sinensis ovulation-stimulating Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases is made of the following Chinese herbal medicine raw materials in parts by weight: 5-15 parts of Angelica sinensis, 5-15 parts of Cyperus rotundus, 20-40 parts of Cuscuta australis, 5-15 parts of Fenugreek, 10-20 parts of Morinda officinalis, 10-20 parts of Cornus officinalis, 10-20 parts of Mulberry, 5-15 parts of Eclipta prostrata, and 5-15 parts of Dendrobium candidum.

[0011] Furthermore, the above-mentioned Angelica sinensis ovulation-stimulating Chinese medicine composition for simplified artificial cycle sequential therapy of various gynecological diseases is made of the following Chinese herbal medicine raw materials in parts by weight: 10 parts of Angelica sinensis, 10 parts of Cyperus rotundus, 30 parts of Cuscuta australis, 10 parts of Fenugreek, 15 parts of Morinda officinalis, 15 parts of Cornus officinalis, 15 parts of Mulberry, 10 parts of Eclipta prostrata, and 10 parts of Dendrobium candidum.

[0012] The present invention also discloses a method for preparing the Chinese medicine composition of Angelica sinensis for promoting ovulation in simplified artificial cycle sequential therapy for various gynecological diseases, which comprises the following steps:

[0013] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0014] 2) Put the crushed raw materials into 5-15 times the amount of distilled water, soak for 20-40 minutes, then heat and decoct. The first decoction time is 0.5-1.5 hours, and filter and collect the liquid medicine;

[0015] 3) Add 4-12 times the amount of water for a second decoction for 0.5-1.5 hours, and filter and collect the liquid medicine;

[0016] 4) The two extracts of step 2) and step 3) are combined, and concentrated to a medicinal solution with a concentration of 1 g / mL or above at 50-70° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0017] The invention also discloses a pharmaceutical preparation, which contains the above-mentioned Chinese medicine composition or is prepared from the above-mentioned Chinese medicine composition.

[0018] Furthermore, in the above-mentioned pharmaceutical preparation, the dosage form of the pharmaceutical preparation includes oral decoction, pills, capsules or granules.

[0019] Furthermore, in the above-mentioned pharmaceutical preparation, the preparation also includes pharmaceutically acceptable excipients.

[0020] Furthermore, in the above-mentioned pharmaceutical preparation, the preparation is a decoction, which is prepared by dissolving a therapeutic amount of drug powder in water when used.

[0021] The present invention also discloses the use of the above-mentioned Chinese medicine composition in preparing a medicine for treating infertility, irregular menstruation or dysmenorrhea. Preferably, infertility, irregular menstruation, dysmenorrhea and other diseases related to the menstrual cycle are selected during the period from the third day of menstruation to the ovulation day when using simplified Chinese medicine artificial cycle sequential therapy.

[0022] Compared with the prior art, the present invention has the following outstanding beneficial effects:

[0023] On the third day of menstruation, the blood sea begins to be empty, and the Yin blood is waiting to be restored. At this time, the follicles are in the early follicular stage, and the hormone level in the body is at the basic state. Since the follicular stage is the foundation stage of the evolution of the entire menstrual cycle, the recovery of Yin blood, the development of follicles, the growth of the endometrium, and the quality of the reproductive endocrine background are all closely related to this stage. During this period, the treatment should be to nourish blood and promote blood circulation, invigorate essence and activate blood circulation. The prescription is Danggui Cuo Lu (mixture) Decoction to promote the full development of follicles and highlight the dominant follicles to facilitate ovulation.

[0024] The angelica in this prescription is sweet, spicy and warm in nature. It enters the liver, heart and spleen meridians, and has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, which is exactly in line with the physiological characteristics of women in this period. Combined with modern pharmacological research, Chinese medicine for promoting blood circulation and removing blood stasis has the effect of improving ovarian microcirculation and promoting the growth and development of follicles; Cyperus rotundus has a spicy, slightly bitter, slightly sweet and neutral taste, and enters the liver, spleen and triple burner meridians. It has the effects of soothing the liver, regulating qi and regulating menstruation. When qi flows, blood flows, and it also relieves women's body that is prone to depression; Cuscuta chinensis has a spicy, sweet and It is neutral, and it enters the liver, kidney and spleen meridians, and has the effects of nourishing the liver and kidney, consolidating essence and calming the fetus; Fenugreek and Morinda officinalis are warm in nature and enter the kidney meridian, one bitter and the other spicy, nourishing the kidney and supporting yang without stagnation; Cornus officinalis, mulberry, and Ecliptae are all sour in taste, and enter the liver and kidney meridians, one warm and the other cold, and neutrally nourish the liver and kidney, while mulberry nourishes yin and moistens dryness, and Ecliptae cools blood and stops bleeding to prevent the risk of angelica stirring bleeding in the early stage of implantation; Dendrobium is sweet and slightly cold in nature, and enters the stomach and kidney meridians, and has the functions of benefiting the stomach to produce fluid, nourishing yin and clearing heat. This prescription is in harmony with yin and yang, yin is quiet and yang is active, yang turns into qi and yin is formed, and promotes the formation and discharge of follicles.

[0025] In addition, the Chinese medicine composition of the present invention also has the advantages of simple preparation, low cost and easy promotion. By simplifying the artificial cycle sequential therapy, the complexity of the treatment process and the economic burden of the patient are reduced, so that more patients can benefit from this treatment plan. At the same time, the Chinese medicine composition of the present invention is extracted from natural plants, which has less side effects and high safety compared to chemical drugs, and is more suitable for long-term treatment. Therefore, the Chinese medicine composition of the present invention not only provides a new treatment option for patients with gynecological diseases, but also provides new ideas and methods for the application of Chinese medicine in the field of gynecological disease treatment, and has broad market prospects and social value. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Figure 2. Weight changes of experimental rats;

[0027] Figure 2 Figure 3. Weight changes of experimental rabbits. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] Example 1

[0030] A set of Chinese medicine compositions for promoting ovulation with angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases is prepared from the following Chinese medicine decoction pieces in parts by weight: 5 parts of angelica sinensis, 5 parts of cyperus rotundus, 20 parts of dodder seeds, 5 parts of fenugreek, 10 parts of Morinda officinalis, 10 parts of cornus officinalis, 10 parts of mulberry, 5 parts of Eclipta prostrata, and 5 parts of dendrobium.

[0031] The preparation method of the Chinese medicine composition of Angelica sinensis for ovulation promotion in simplified artificial cycle sequential therapy for various gynecological diseases comprises the following steps:

[0032] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0033] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0034] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0035] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0036] Example 2

[0037] A set of Chinese medicine compositions for promoting ovulation with angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases is prepared from the following Chinese medicine decoction pieces in parts by weight: 10 parts of angelica sinensis, 10 parts of cyperus rotundus, 30 parts of dodder seeds, 10 parts of fenugreek, 15 parts of Morinda officinalis, 15 parts of cornus officinalis, 15 parts of mulberry, 10 parts of Eclipta prostrata, and 10 parts of dendrobium.

[0038] The preparation method of the Chinese medicine composition of Angelica sinensis for ovulation promotion in simplified artificial cycle sequential therapy for various gynecological diseases comprises the following steps:

[0039] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0040] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0041] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0042] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0043] Example 3

[0044] A set of Chinese medicine compositions for promoting ovulation with angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases is prepared from the following Chinese medicine decoction pieces in parts by weight: 15 parts of angelica sinensis, 15 parts of cyperus rotundus, 40 parts of dodder seeds, 15 parts of fenugreek, 20 parts of Morinda officinalis, 20 parts of cornus officinalis, 20 parts of mulberry, 15 parts of Eclipta prostrata, and 15 parts of dendrobium.

[0045] The preparation method of the Chinese medicine composition of Angelica sinensis for ovulation promotion in simplified artificial cycle sequential therapy for various gynecological diseases comprises the following steps:

[0046] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0047] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0048] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0049] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0050] Test Example 1

[0051] Rat experiments.

[0052] According to the ratio of Angelica sinensis egg-stimulating (mixture) soup (i.e., the ratio of Example 2 of the present invention), prepare the following medicinal materials: 10 grams of Angelica sinensis, 10 grams of Cyperus rotundus, 30 grams of Cuscuta australis, 10 grams of Fenugreek, 15 grams of Morinda officinalis, 15 grams of Cornus officinalis, 15 grams of Mulberry, 10 grams of Eclipta prostrata, and 10 grams of Dendrobium. All medicinal materials must meet the standards of the "Chinese Pharmacopoeia" and be crushed for standby use after cleaning and drying. The above medicinal materials are put into 10 times the amount of distilled water (i.e., 1g is added to 10mL of water, the same below), soaked for 30 minutes and then heated and decocted. The first decoction time is 1 hour, and the medicinal liquid is filtered and collected; 8 times the amount of water is added for the second decoction, the time is 1 hour, and the medicinal liquid is filtered and collected. The two extracts are combined and concentrated to a 1g / mL medicinal liquid at 60°C using a rotary evaporator. The medicinal liquid is then freeze-dried to prepare a medicinal powder for standby use. The medicinal powder is prepared into an aqueous solution at a dosage of 1.5g / kg (rat mass) for oral administration to rats. Angelica Replacement: Angelica was replaced with Astragalus, and the Angelica in the prescription was removed from the Angelica-Removing Group, and the preparation method was the same as above.

[0053] Female SD rats were randomly divided into 6 groups, namely blank control group, cisplatin control group, motherwort granule group, prescription group, angelica replacement group and angelica removal group. The blank control group was given 3mL / kg normal saline, the cisplatin control group was injected with 3mg / kg cisplatin, the motherwort granule group was given 1.5g / kg of motherwort granule aqueous solution, and the prescription group, angelica replacement group and angelica removal group were given 1.5g / kg of Chinese medicine aqueous solution. The experimental cycle included 7 consecutive days of intraperitoneal injection of cisplatin to construct a rat model of premature ovarian failure, 21 days of normal feeding period and 14 days of drug administration period, followed by a 28-day drug withdrawal observation period. The estrous cycle changes, serum estradiol (E2) and follicle-stimulating hormone (FSH) levels, body weight changes and coat color changes of the rats were detected, as shown in Tables 1, 2 and Figure 1 shown.

[0054] The experimental results showed that after 14 days of administration, the female SD rats in the prescription group had improved hair gloss, good mental state, and normal estrous cycle. The serum estradiol level in the prescription group increased significantly (about 80pg / mL), and the follicle-stimulating hormone level decreased significantly (about 6ng / mL). The number of mature follicles in the ovaries increased significantly (about 10 / each rat), and the number of atretic follicles decreased significantly (about 3 / each rat). The hair color was more lustrous than that in the cisplatin control group, and the degree of improvement was obvious. The reproductive success rate of rats in the prescription group was significantly higher than that of other groups, reaching 80%.

[0055] Although certain therapeutic effects were observed in the angelica replacement group and the angelica removal group, the effects were relatively weakened. In the angelica replacement group, serum estradiol levels (about 70pg / mL) failed to recover significantly, follicle-stimulating hormone levels (about 8ng / mL) were high, the degree of improvement in ovarian pathology was low, and the reproductive success rate was low (about 50%). In the angelica removal group, serum estradiol levels (about 60pg / mL), follicle-stimulating hormone levels (about 7ng / mL), the number of mature follicles in the ovaries was low (about 8 / rat), the number of atretic follicles was high (about 5 / rat), weight changes were not obvious, the degree of improvement in coat color was also low, and the reproductive success rate was the lowest (about 40%).

[0056] Table 1 Changes of various physiological indicators of rats

[0057]

[0058] Table 2 Body weight changes of rats

[0059]

[0060] The above experimental results show that Angelica Root Egg-Stimulating Decoction (Mixture) has significant therapeutic effects on the treatment of infertility, menstrual disorders, dysmenorrhea and other diseases, and the role of each ingredient in the prescription is indispensable. The effects of the Angelica Root Replacement Group and the Angelica Root-Removal Group were relatively weakened, indicating the importance of each ingredient in the overall efficacy. This prescription provides an effective alternative for the treatment of related diseases, and its effect is significantly better than that of the Motherwort Granule Group.

[0061] Test Example 2

[0062] New Zealand White Rabbit Experiment.

[0063] The angelica ovum-stimulating (mixture) soup medicinal materials (i.e., the formula of Example 2 of the present invention) that meet the standards of the Chinese Pharmacopoeia are selected, including 10 grams of angelica, 10 grams of cyperus, 30 grams of dodder seeds, 10 grams of fenugreek, 15 grams of Morinda officinalis, 15 grams of Cornus officinalis, 15 grams of mulberry, 10 grams of Eclipta prostrata and 10 grams of Dendrobium. The medicinal materials are cleaned, dried and crushed for standby use. The medicinal materials are added to 10 times the amount of distilled water and decocted in water after soaking for 30 minutes. The first decoction time is 1 hour, and the liquid is filtered; 8 times the amount of water is added for the second decoction, the time is 1 hour, and the liquid is filtered. The two extracts are combined and concentrated to a 1g / mL medicinal solution using a rotary evaporator. The concentrated medicinal solution is dried at 60°C to obtain a medicinal powder. Before the experimental medication, the medicinal powder is prepared into an aqueous solution at a dose of 10g / kg (white rabbit body weight) for experimental use. Angelica Replacement: Angelica was replaced with Astragalus, and the Angelica in the prescription was removed from the Angelica-Removing Group, and the preparation method was the same as above.

[0064] Female New Zealand white rabbits were randomly divided into 6 groups, namely blank control group, cisplatin control group, motherwort granule group, prescription group, angelica replacement group and angelica removal group. The blank control group was given 2mL / kg normal saline, the cisplatin control group was injected with 2mg / kg cisplatin, the motherwort granule group was given 2g / kg of motherwort granule aqueous solution, and the prescription group, angelica replacement group and angelica removal group were given 10g / kg of Chinese medicine aqueous solution, respectively. The experimental cycle included 7 consecutive days of intraperitoneal cisplatin injection (dose of 2mg / kg) to construct an ovarian premature failure model, 21 days of normal feeding period and 14 days of drug administration period, followed by 28 days of drug withdrawal observation period. The estrous cycle changes, serum estradiol (E2) and follicle-stimulating hormone (FSH) levels, body weight changes and coat color changes of the rabbits were detected. As shown in Tables 3, 4 and Figure 2 shown.

[0065] The experimental results showed that after 14 days of administration, the female New Zealand white rabbits' hair luster improved, their mental state was good, and their estrous cycle returned to normal. The serum estradiol level in the prescription group increased significantly (about 90pg / mL), and the follicle-stimulating hormone level decreased significantly (about 5ng / mL). The number of mature follicles in the ovaries increased significantly (about 12 / each rabbit), and the number of atretic follicles decreased significantly (about 2 / each rabbit). The hair color was more lustrous than that of the cisplatin control group, and the degree of improvement was obvious. The reproductive success rate of rabbits in the prescription group was significantly higher than that of other groups, reaching 85%.

[0066] Although certain therapeutic effects were observed in the angelica replacement group and the angelica removal group, the effects were relatively weakened. In the angelica replacement group, serum estradiol levels (about 75pg / mL) failed to recover significantly, follicle-stimulating hormone levels (about 7ng / mL) were high, the degree of improvement in ovarian pathology was low, and the reproductive success rate was low (about 60%). In the angelica removal group, serum estradiol levels (about 65pg / mL), follicle-stimulating hormone levels (about 8ng / mL), the number of mature follicles in the ovaries was low (about 7 / each rabbit), the number of atretic follicles was high (about 4 / each rabbit), weight changes were not obvious, the degree of improvement in coat color was also low, and the reproductive success rate was the lowest (about 45%).

[0067] All indicators of the blank control group remained at healthy levels, with serum estradiol levels of about 100pg / mL, follicle-stimulating hormone levels of about 4ng / mL, the number of mature follicles of about 14 per rabbit, the number of atretic follicles of about 1 per rabbit, body weight changes remained basically unchanged, coat color was glossy, and the fertility success rate was about 90%.

[0068] Table 3 Changes of various physiological indicators of white rabbits

[0069]

[0070]

[0071] Table 4 Weight changes of white rabbits

[0072]

[0073] From the above test cases, it can be seen that Danggui Ovulation-stimulating Decoction (mixture) has significant therapeutic effects on the treatment of infertility, menstrual disorders, dysmenorrhea and other diseases, and the role of each ingredient in the prescription is indispensable. The effects of the Danggui replacement group and the Danggui removal group were relatively weakened, indicating the importance of Danggui ingredients in the overall efficacy. This prescription provides an effective alternative for the treatment of related diseases, and its effect is significantly better than that of the Yi Mu Cao granule group.

[0074] The above are only a few preferred embodiments of the present invention, which are described in a more specific and detailed manner, but they cannot be understood as limiting the scope of the present invention. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A set of Chinese medicine compositions for ovulation promotion by Angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases, characterized in that: It is made from the following Chinese herbal medicine raw materials: angelica, cyperus rotundus, dodder seed, fenugreek, Morinda officinalis, cornus officinalis, mulberry, Eclipta prostrata and dendrobium.

2. According to claim 1, a set of Chinese medicine compositions for ovulation promotion by Angelica sinensis for simplified artificial cycle sequential therapy for various gynecological diseases, characterized in that: The invention is prepared from the following Chinese medicinal decoction pieces raw materials in parts by weight: 5-15 parts of angelica sinensis, 5-15 parts of cyperus rotundus, 20-40 parts of dodder seeds, 5-15 parts of fenugreek, 10-20 parts of Morinda officinalis, 10-20 parts of cornus officinalis, 10-20 parts of mulberry, 5-15 parts of Eclipta prostrata and 5-15 parts of dendrobium.

3. A set of Chinese medicine compositions for promoting ovulation in simplified artificial cycle sequential therapy for various gynecological diseases according to claim 2, characterized in that: The invention is prepared from the following Chinese medicinal decoction pieces in parts by weight: 10 parts of angelica sinensis, 10 parts of cyperus rotundus, 30 parts of dodder seeds, 10 parts of fenugreek, 15 parts of Morinda officinalis, 15 parts of cornus officinalis, 15 parts of mulberry, 10 parts of Eclipta prostrata and 10 parts of dendrobium.

4. The method for preparing the Chinese medicine composition for promoting ovulation of angelica sinensis for simplified artificial cycle sequential therapy of various gynecological diseases according to any one of claims 1 to 3, characterized in that: The following steps are involved: 1) Weigh the raw materials according to the formula, wash, dry and crush them for later use; 2) Put the crushed raw materials into 5-15 times the amount of distilled water, soak for 20-40 minutes, then heat and decoct. The first decoction time is 0.5-1.5 hours, and filter and collect the liquid medicine; 3) Add 4-12 times the amount of water for a second decoction for 0.5-1.5 hours, and filter and collect the liquid; 4) The two extracts of step 2) and step 3) are combined, and concentrated to a medicinal solution with a concentration of 1 g / mL or above at 50-70° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

5. A pharmaceutical preparation, characterized in that Contains the Chinese medicine composition as described in any one of claims 1 to 3, or is made from the above Chinese medicine composition.

6. The pharmaceutical preparation according to claim 5, characterized in that The dosage form of the pharmaceutical preparation includes oral decoction, pills, capsules or granules.

7. The pharmaceutical preparation according to claim 6, characterized in that The preparation also includes pharmaceutically acceptable excipients.

8. The pharmaceutical preparation according to claim 5, characterized in that The preparation is a decoction, which is prepared by dissolving a therapeutic amount of drug powder in water when used.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating infertility, irregular menstruation or dysmenorrhea.

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