Traditional Chinese medicine preparation for treating cerebral infarction sequelae

Abstract

The invention discloses a traditional Chinese medicine preparation for treating cerebral infarction sequelae, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation for treating cerebral infarction sequelae is prepared from the following components in parts by weight: 30-33 parts of creeping fissistigma root, 8-12 parts of ligusticum wallichii, 6-8 parts of liquorice, 9-14 parts of astragalus membranaceus, 10-15 parts of chrysanthemum, 18-22 parts of ginseng under forest, 6-8 parts of fried coix seed, 10-12 parts of Chinese yam, 18-19 parts of uncaria, 13-15 parts of poria with hostwood, 5-7 parts of fried gordon euryale seed, 10-12 parts of fried hyacinth bean and 8-12 parts of salvia miltiorrhiza. The traditional Chinese medicine composition is formed by combining a plurality of herbal plants, due to homology of medicine and food, the five elements of yin and yang are efficiently conditioned, the cerebral infarction sequelae and neuropathic pain can be obviously improved after the traditional Chinese medicine composition is taken for a long time, and the traditional Chinese medicine composition has the multiple effects of improving the cerebral infarction sequelae and neuropathic pain, promoting neural function recovery, eliminating dampness in the body, strengthening the spleen and the stomach, removing halitosis, discharging fat, losing weight and the like.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparations, in particular to a Chinese medicine preparation for treating sequelae of cerebral infarction. Background Art

[0002] Cerebral infarction is a type of brain tissue ischemia and hypoxic necrosis caused by interruption of blood supply to the brain. Common causes include atherosclerosis, thrombosis, embolism, etc. Its symptoms lead to hemiplegia, aphasia, paresthesia, coma, headache, vomiting, and vision or balance problems.

[0003] Among them, sequelae of cerebral infarction refer to the symptoms such as hemiplegia, language disorder or facial paralysis that still exist one year after the onset of cerebral infarction. This period is also called the sequelae period of cerebral infarction. Compared with the recovery period, the recovery speed and degree are slower. The sequelae of cerebral infarction mainly include hemiplegia (hemiplegia), hemilimb disorder, limb numbness, hemianopsia, and aphasia.

[0004] Currently, there are many drugs for treating cerebral infarction on the market, such as western medicines such as aspirin and atorvastatin calcium tablets, and traditional Chinese medicines such as Naoxintong and Tianxintai. However, there are fewer drugs for restoring neurological function after cerebral infarction. In clinical practice, it has been observed that patients with sequelae of cerebral infarction have certain difficulty swallowing drugs in the form of granules due to nerve damage. In addition, the treatment of sequelae of cerebral infarction and neuropathic pain is a long process. Patients who take medication for a long time are prone to problems such as low compliance with medication. In particular, patients with cerebral infarction are more likely to have emotional diseases than ordinary people due to the disorder of body metabolism. Severe cases even refuse to take medication.

[0005] Therefore, the existing technology for the treatment of sequelae of cerebral infarction has formed a food-based health care treatment concept, and earthworm egg soup, gastrodia elata pig brain porridge, earthworm peach blossom cake, astragalus stewed snake meat, etc. are often used. However, since the earthworms, gastrodia elata, earthworms and snake meat are scarce and have a bad taste, they are easy to affect the compliance of patients. Summary of the invention

[0006] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine preparation for treating sequelae of cerebral infarction, which solves the problems raised in the above-mentioned background technology.

[0007] To achieve the above objectives, the present invention is implemented by the following technical scheme: a Chinese medicine preparation for treating sequelae of cerebral infarction, the Chinese medicine preparation comprising the following components in parts by weight:

[0008] 30-33 parts of Climbing Rock Red, 8-12 parts of Chuanxiong, 6-8 parts of Licorice, 9-14 parts of Astragalus, 10-15 parts of Chrysanthemum, 18-22 parts of Linxiaginseng, 6-8 parts of stir-fried Coix Seed, 10-12 parts of Dioscorea Opposita, 18-19 parts of Uncaria Rhynchophylla, 13-15 parts of Poria, 5-7 parts of stir-fried Euryale ferox, 10-12 parts of stir-fried Lentil, and 8-12 parts of Salvia miltiorrhiza.

[0009] Among them, the red climbing rock has the effects of dispelling wind and dampness, relieving pain and spasm, dispersing blood stasis and opening the orifices, and lowering blood lipids in traditional Chinese medicine preparations; Chuanxiong has the effects of promoting blood circulation and removing blood stasis, dispelling wind and relieving pain, and promoting blood circulation and relieving qi in traditional Chinese medicine preparations; Licorice has the effects of harmonizing various medicines, removing phlegm and relieving cough, and relieving acute pain in traditional Chinese medicine preparations; Astragalus has the effects of replenishing qi and blood, and benefiting the middle in traditional Chinese medicine preparations; Chrysanthemum has the effects of dispelling wind and heat, detoxifying and reducing swelling in traditional Chinese medicine preparations; Linxia ginseng has the effects of greatly tonic It has the effects of invigorating qi, promoting body fluid and calming the mind; fried coix seed has the effects of promoting diuresis and removing dampness in traditional Chinese medicine preparations; yam has the effects of tonifying the spleen and strengthening the stomach in traditional Chinese medicine preparations; Uncaria rhynchophylla has the effects of calming wind and stopping spasms in traditional Chinese medicine preparations; Poria has the effect of harmonizing qi and blood in traditional Chinese medicine preparations; fried Euryale ferox has the effects of strengthening the spleen and stomach in traditional Chinese medicine preparations; fried lentil has the effects of removing dampness and promoting diuresis in traditional Chinese medicine preparations; Salvia miltiorrhiza has the effects of promoting blood circulation, removing blood stasis, relieving menstruation and relieving pain, and relieving restlessness and calming the mind in traditional Chinese medicine preparations.

[0010] A further improvement of the technical solution of the present invention is that the Chinese medicine preparation is specifically composed of the following raw materials by weight:

[0011] 33 parts of Rhizoma Climbing Rocks, 11 parts of Rhizoma Chuanxiong, 6 parts of Radix Glycyrrhizae, 14 parts of Radix Astragali, 12 parts of Flos Chrysanthemi, 20 parts of Ginseng under the Forest, 8 parts of stir-fried Semen Coix, 12 parts of Dioscorea Oppositae, 18 parts of Rhizoma Uncariae, 15 parts of Poria, 5 parts of stir-fried Euryale ferox, 10 parts of stir-fried Lentils, and 9 parts of Salvia miltiorrhiza.

[0012] A further improvement of the technical solution of the present invention is that the Chinese medicine preparation is specifically composed of the following raw materials by weight:

[0013] 30 parts of Rhizoma Climbing Rocks, 10 parts of Rhizoma Chuanxiong, 6 parts of Radix Glycyrrhizae, 8 parts of Radix Astragali, 12 parts of Flos Chrysanthemi, 10 parts of Ginseng under the Forest, 8 parts of stir-fried Semen Coix, 12 parts of Dioscorea Oppositae, 14 parts of Rhizoma Uncariae, 10 parts of Poria, 5 parts of stir-fried Euryale ferox, 15 parts of stir-fried Lentils, and 11 parts of Radix Salviae Miltiorrhizae.

[0014] A further improvement of the technical solution of the present invention is that the dosage form of the traditional Chinese medicine preparation includes oral preparation, powder and pill.

[0015] A further improvement of the technical solution of the present invention is that the powder-type Chinese medicine preparation comprises the following specific preparation steps:

[0016] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0017] Step 2: sterilize the raw material pretreated in step 1 with high pressure and high temperature steam for 45 minutes, take out the raw material and dry it until the moisture content is less than 7%;

[0018] Step 3: The dried raw materials obtained in step 2 are crushed and passed through a 130-mesh sieve. After all the combined drugs are prepared into powder, they are mixed evenly and packaged in fresh-keeping sealed bags at a dosage of 15 g / bag per serving.

[0019] A further improvement of the technical solution of the present invention is that the Chinese medicine preparation in pill form comprises the following specific preparation steps:

[0020] Step 1: Prepare the Chinese medicine powder according to the Chinese medicine preparation method for powder dosage form;

[0021] Step 2: Add the auxiliary material astragalus honey into the powder and mix thoroughly. The amount of astragalus honey added is 1:1.2 based on the weight of the powder. Heat to 70-80°C during the mixing process.

[0022] Step 3: Prepare the powder mixed in step 2 at 10 g / pill and package it in small fresh-keeping ziplock bags.

[0023] A further improvement of the technical solution of the present invention is that the Chinese medicine preparation in oral dosage form comprises the following specific preparation steps:

[0024] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0025] Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:40-50mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can.

[0026] Beneficial Effects

[0027] Compared with the prior art, the beneficial effects of the present invention are that it is composed of a combination of multiple herbal plants, and because the herbs and food have the same origin, they can effectively regulate the five elements of yin and yang. Long-term use can significantly improve the sequelae of cerebral infarction and neuropathic pain, and has the effects of improving the sequelae of cerebral infarction, neuropathic pain, promoting the recovery of nerve function, and eliminating moisture in the body, strengthening the spleen and stomach, eliminating bad breath, and expelling fat and losing weight.

[0028] The invention also has anti-viral, anti-inflammatory and anti-tumor effects, and can effectively prevent the onset of cardiovascular diseases such as cerebral infarction and atherosclerosis. Long-term use can also enhance the body's nonspecific immunity. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1A schematic diagram of the preparation process of traditional Chinese medicine powder for treating sequelae of cerebral infarction;

[0030] Figure 2 A schematic diagram of the preparation process of traditional Chinese medicine pills for treating sequelae of cerebral infarction;

[0031] Figure 3 Schematic diagram of the preparation process of oral Chinese medicine for treating sequelae of cerebral infarction. DETAILED DESCRIPTION

[0032] Various exemplary embodiments, features and aspects of the present application will be described in detail below with reference to the accompanying drawings. The same reference numerals in the accompanying drawings represent elements with the same or similar functions. Although various aspects of the embodiments are shown in the accompanying drawings, the drawings are not necessarily drawn to scale unless otherwise specified.

[0033] The word “exemplary” is used exclusively herein to mean “serving as an example, example, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.

[0034] In addition, in order to better illustrate the present application, numerous specific details are provided in the specific examples below. It should be understood by those skilled in the art that the present application can also be implemented without certain specific details. In some examples, methods, means, and elements well known to those skilled in the art are not described in detail in order to highlight the subject matter of the present application.

[0035] The present invention provides a traditional Chinese medicine preparation for treating sequelae of cerebral infarction, wherein the traditional Chinese medicine preparation comprises the following components in parts by weight:

[0036] 30-33 parts of Climbing Rock Red, 8-12 parts of Chuanxiong, 6-8 parts of Licorice, 9-14 parts of Astragalus, 10-15 parts of Chrysanthemum, 18-22 parts of Linxiaginseng, 6-8 parts of stir-fried Coix Seed, 10-12 parts of Dioscorea Opposita, 18-19 parts of Uncaria Rhynchophylla, 13-15 parts of Poria, 5-7 parts of stir-fried Euryale ferox, 10-12 parts of stir-fried Lentil, and 8-12 parts of Salvia miltiorrhiza.

[0037] Among them, the red climbing rock has the effects of dispelling wind and dampness, relieving pain and spasm, dispersing blood stasis and opening the orifices, and lowering blood lipids in traditional Chinese medicine preparations; Chuanxiong has the effects of promoting blood circulation and removing blood stasis, dispelling wind and relieving pain, and promoting blood circulation and relieving qi in traditional Chinese medicine preparations; Licorice has the effects of harmonizing various medicines, removing phlegm and relieving cough, and relieving acute pain in traditional Chinese medicine preparations; Astragalus has the effects of replenishing qi and blood, and benefiting the middle in traditional Chinese medicine preparations; Chrysanthemum has the effects of dispelling wind and heat, detoxifying and reducing swelling in traditional Chinese medicine preparations; Linxia ginseng has the effects of greatly tonic It has the effects of invigorating qi, promoting body fluid and calming the mind; fried coix seed has the effects of promoting diuresis and removing dampness in traditional Chinese medicine preparations; yam has the effects of tonifying the spleen and strengthening the stomach in traditional Chinese medicine preparations; Uncaria rhynchophylla has the effects of calming wind and stopping spasms in traditional Chinese medicine preparations; Poria has the effect of harmonizing qi and blood in traditional Chinese medicine preparations; fried Euryale ferox has the effects of strengthening the spleen and stomach in traditional Chinese medicine preparations; fried lentil has the effects of removing dampness and promoting diuresis in traditional Chinese medicine preparations; Salvia miltiorrhiza has the effects of promoting blood circulation, removing blood stasis, relieving menstruation and relieving pain, and relieving restlessness and calming the mind in traditional Chinese medicine preparations.

[0038] The dosage forms of the Chinese medicine preparation include oral preparation, powder and pill.

[0039] The powdered Chinese medicine preparation comprises the following specific preparation steps:

[0040] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0041] Step 2: sterilize the raw material pretreated in step 1 with high pressure and high temperature steam for 45 minutes, take out the raw material and dry it until the moisture content is less than 7%;

[0042] Step 3: The dried raw materials obtained in step 2 are crushed and passed through a 130-mesh sieve. After all the combined drugs are prepared into powder, they are mixed evenly and packaged in fresh-keeping sealed bags at a dosage of 15 g / bag per serving.

[0043] The Chinese medicine preparation in pill form comprises the following specific preparation steps:

[0044] Step 1: prepare Chinese medicine powder according to the Chinese medicine preparation method for powder dosage form;

[0045] Step 2: Add the auxiliary material astragalus honey into the powder and mix thoroughly. The amount of astragalus honey added is 1:1.2 based on the weight of the powder. Heat to 70-80°C during the mixing process.

[0046] Step 3: Prepare the powder mixed in step 2 at 10 g / pill and package it in small fresh-keeping ziplock bags.

[0047] The oral dosage form of the Chinese medicine preparation comprises the following specific preparation steps:

[0048] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0049] Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:40-50mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can.

[0050] The following is a further description with reference to the embodiments.

[0051] Example 1. The raw material composition of this example is specifically as follows: 33 parts of Rhizoma Climbing Rocks, 11 parts of Rhizoma Chuanxiong, 6 parts of Glycyrrhizae, 14 parts of Radix Astragali, 12 parts of Chrysanthemum, 20 parts of Ginseng under the Forest, 8 parts of stir-fried Coix Seed, 12 parts of Dioscorea Opposita, 18 parts of Uncaria Rhynchophylla, 15 parts of Poria, 5 parts of stir-fried Euryale ferox, 10 parts of stir-fried Lentils, and 9 parts of Salvia miltiorrhiza.

[0052] This embodiment is prepared by powder, and the specific preparation process is as follows:

[0053] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0054] Step 2: sterilize the raw material pretreated in step 1 with high pressure and high temperature steam for 45 minutes, take out the raw material and dry it until the moisture content is less than 7%;

[0055] Step 3: The dried raw materials obtained in step 2 are crushed and passed through a 130-mesh sieve. After all the combined drugs are prepared into powder, they are mixed evenly and packaged in fresh-keeping sealed bags at a dosage of 15 g / bag per serving.

[0056] Example 2. The raw material composition of this example is specifically as follows: 30 parts of Rhizoma Climbingii, 8 parts of Rhizoma Chuanxiong, 6 parts of Rhizoma Licorice, 9 parts of Radix Astragali, 10 parts of Flos Chrysanthemi, 18 parts of Ginseng, 6 parts of stir-fried Semen Coix, 10 parts of Dioscorea Opposita, 18 parts of Rhizoma Uncariae, 13 parts of Poria, 5 parts of stir-fried Euryale ferox, 10 parts of stir-fried Lentils, and 8 parts of Salvia miltiorrhiza.

[0057] This embodiment adopts the preparation method of pill form, which is as follows:

[0058] Step 1: Prepare the powder according to the method described in Example 1;

[0059] Step 2: Add the auxiliary material astragalus honey into the powder and mix thoroughly. The amount of astragalus honey added is 1:1.2 based on the weight of the powder. Heat to 70-80°C during the mixing process.

[0060] Step 3: Prepare the powder mixed in step 2 at 10 g / pill and package it in small fresh-keeping ziplock bags.

[0061] Example 3, the raw material composition of this example is specifically as follows: 30 parts of climbing rock red, 10 parts of chuanxiong, 6 parts of licorice, 8 parts of astragalus, 12 parts of chrysanthemum, 10 parts of forest ginseng, 8 parts of fried coix seeds, 12 parts of yam, 14 parts of Uncaria rhynchophylla, 10 parts of poria, 5 parts of fried Euryale ferox, 15 parts of fried lentils, and 11 parts of salvia miltiorrhiza;

[0062] This embodiment adopts the preparation method of oral dosage form, which is as follows:

[0063] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0064] Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:40mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can;

[0065] The Chinese medicine preparation is finally made into canned tea with a specification of 300 mL / can in step 2.

[0066] Example 4, the raw material composition of this example is specifically, 32 parts of climbing rock red, 12 parts of chuanxiong, 7 parts of licorice, 8 parts of astragalus, 11 parts of chrysanthemum, 13 parts of forest ginseng, 9 parts of fried coix seed, 13 parts of yam, 16 parts of Uncaria rhynchophylla, 9 parts of poria, 5 parts of fried Euryale ferox, 12 parts of fried lentils, and 9 parts of salvia miltiorrhiza;

[0067] This embodiment adopts the preparation method of oral dosage form, which is as follows:

[0068] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0069] Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:50mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can;

[0070] The Chinese medicine preparation is finally made into canned tea with a specification of 300 mL / can in step 2.

[0071] Example 5, the raw material composition of this example is specifically, 33 parts of climbing rock red, 12 parts of chuanxiong, 8 parts of liquorice, 14 parts of astragalus, 15 parts of chrysanthemum, 22 parts of forest ginseng, 8 parts of fried coix seed, 12 parts of yam, 19 parts of Uncaria rhynchophylla, 15 parts of poria, 7 parts of fried Euryale ferox, 12 parts of fried lentils, and 12 parts of salvia miltiorrhiza;

[0072] This embodiment adopts the preparation method of oral dosage form, which is as follows:

[0073] Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust;

[0074] Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:50mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can;

[0075] The Chinese medicine preparation is finally made into canned tea with a specification of 300 mL / can in step 2.

[0076] In summary, Example 1, Example 2, Example 3 and Example 4 are presented in the form of powder, pill and oral preparation respectively. The three dosage forms exclude the situation that drugs in the form of granules have difficulty in swallowing. Therefore, further clinical trials will be conducted on the efficacy of each dosage form of Example 1, Example 2, Example 3, Example 4 and Example 5.

[0077] 100 patients with sequelae of cerebral infarction were selected to orally take the Chinese medicine composition of Example 1 daily; the administration method was: 2 bags (15 g / bag) each time, brewed with 500 ml of boiling water, taken twice a day, once in the morning and once in the evening, taking 30 bags as a course of treatment, and the efficacy was evaluated after taking two courses of treatment.

[0078] Inclusion criteria: patients who meet both TCM and Western medicine diagnostic criteria for sequelae of cerebral infarction. TCM diagnostic criteria are based on the "Standards for Diagnosis and Therapeutic Effect Evaluation of Stroke"; Western medicine diagnostic criteria are based on the "Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial)" formulated by the Disease Control Department of the Ministry of Health of China and the Neurological Branch of the Chinese Medical Association in 2005; NHISS score between 21-30; signed consent forms; complete data; and high compliance.

[0079] Exclusion criteria: patients with cognitive impairment; patients with unclear consciousness; patients who do not meet any of the criteria for the Diagnosis and Therapeutic Effect Evaluation of Stroke or the Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial Implementation).

[0080] Evaluation criteria: The National Institutes of Health Neurological Deficit Score (NHISS) was used to score the effectiveness of neurological function recovery in patients using the drug.

[0081] Significantly effective: NHISS score drops below 4 points or NHISS score decreases by more than 10 points;

[0082] Effective: NHISS score decreased by more than 3 points but less than 10 points;

[0083] Ineffective: NHISS score decreased by less than 3 points;

[0084] The results showed that among 100 cases of sequelae of cerebral infarction, 87 were significantly effective, 12 were effective, and 1 was ineffective. The significant effective rate was 87% and the total effective rate was 99%.

[0085] 100 patients with sequelae of cerebral infarction were selected and orally took the Chinese medicine pills of Example 2 every day; the method of taking was: taking the pills of the Chinese medicine composition every day, 10 pills / time, twice / day, taking 30 days as a course of treatment, and the efficacy was evaluated after taking two courses of treatment.

[0086] Inclusion criteria: patients who meet both TCM and Western medicine diagnostic criteria for sequelae of cerebral infarction. TCM diagnostic criteria are based on the "Standards for Diagnosis and Therapeutic Effect Evaluation of Stroke"; Western medicine diagnostic criteria are based on the "Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial)" formulated by the Disease Control Department of the Ministry of Health of China and the Neurological Branch of the Chinese Medical Association in 2005; NHISS score between 10-21; signed consent forms; complete data; and high compliance.

[0087] Exclusion criteria: patients with cognitive impairment; patients with unclear consciousness; patients who do not meet any of the criteria for the Diagnosis and Therapeutic Effect Evaluation of Stroke or the Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial Implementation).

[0088] Significantly effective: NHISS score drops below 4 points or NHISS score decreases by more than 10 points;

[0089] Effective: NHISS score decreased by more than 3 points but less than 10 points;

[0090] Ineffective: NHISS score decreased by less than 3 points;

[0091] The results showed that among 100 cases of sequelae of cerebral infarction, 80 were significantly effective, 19 were effective, and 1 was ineffective. The significant effective rate was 80% and the total effective rate was 99%.

[0092] 100 patients with sequelae of cerebral infarction were selected to orally take the Chinese medicine canned tea of ​​Example 3 every day; the method of taking was: taking 300 ml of the Chinese medicine canned tea of ​​Example 3 every day, one bottle / day, taking 15 days as a course of treatment, and the efficacy was evaluated after taking two courses of treatment.

[0093] Inclusion criteria: Positive symptoms include: paresthesia (such as skin formication or tingling), spontaneous progressive (non-stimulation-induced) pain, induced pain (such as stimulation-induced pain and hyperesthesia), shooting and electric shock-like sensations, etc.

[0094] Exclusion criteria: patients with cognitive impairment; patients with unclear consciousness; patients with multiple underlying diseases;

[0095] Evaluation criteria: based on the degree of the main complaint of pain (VRS method);

[0096] Significantly effective: The pain level of the VRS method was reduced by more than two levels or to zero;

[0097] Effective: VRS pain level is reduced or above;

[0098] Ineffective: There was no significant change in the pain level scored by VRS method;

[0099] The results showed that among 100 cases of sequelae of cerebral infarction, 73 were significantly effective, 23 were effective, and 4 were ineffective. The significant effective rate was 73% and the total effective rate was 96%.

[0100] 100 patients with sequelae of cerebral infarction were selected to orally take the Chinese medicine canned tea of ​​Example 4 every day; the method of taking was: taking 300 ml of the Chinese medicine canned tea of ​​Example 3 every day, one bottle / day, taking 15 days as a course of treatment, and the efficacy was evaluated after taking two courses of treatment.

[0101] Inclusion criteria: patients who meet both TCM and Western medicine diagnostic criteria for sequelae of cerebral infarction. TCM diagnostic criteria are based on the "Standards for Diagnosis and Therapeutic Effect Evaluation of Stroke"; Western medicine diagnostic criteria are based on the "Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial)" formulated by the Disease Control Department of the Ministry of Health of China and the Neurological Branch of the Chinese Medical Association in 2005; NHISS score between 21-30; signed consent forms; complete data; and high compliance.

[0102] Exclusion criteria: patients with cognitive impairment; patients with unclear consciousness;

[0103] Evaluation criteria: The National Institutes of Health Neurological Deficit Score (NHISS) was used to score the effectiveness of neurological function recovery in patients using the drug.

[0104] Markedly effective: NHISS score drops below 4 points or NHISS score decreases by more than 8 points;

[0105] Effective: NHISS score decreased by more than 2 points but less than 8 points;

[0106] Ineffective: NHISS score decreased by less than 2 points;

[0107] The results showed that among 100 cases of sequelae of cerebral infarction, 84 were significantly effective, 15 were effective, and 1 was ineffective. The significant effective rate was 84% ​​and the total effective rate was 99%.

[0108] 100 patients with sequelae of cerebral infarction were selected to orally take the Chinese medicine canned tea of ​​Example 5 every day; the method of taking was: taking 300 ml of the Chinese medicine canned tea of ​​Example 3 every day, one bottle / day, taking 15 days as a course of treatment, and the efficacy was evaluated after taking two courses of treatment.

[0109] Inclusion criteria: patients who meet both TCM and Western medicine diagnostic criteria for sequelae of cerebral infarction. TCM diagnostic criteria are based on the "Standards for Diagnosis and Therapeutic Effect Evaluation of Stroke"; Western medicine diagnostic criteria are based on the "Guidelines for the Prevention and Treatment of Cerebrovascular Disease in China (Trial)" formulated by the Disease Control Department of the Ministry of Health of China and the Neurological Branch of the Chinese Medical Association in 2005; NHISS score between 21-30; signed consent forms; complete data; and high compliance.

[0110] Exclusion criteria: patients with cognitive impairment; patients with unclear consciousness;

[0111] Evaluation criteria: The National Institutes of Health Neurological Deficit Score (NHISS) was used to score the effectiveness of neurological function recovery in patients using the drug.

[0112] Markedly effective: NHISS score drops below 4 points or NHISS score decreases by more than 8 points;

[0113] Effective: NHISS score decreased by more than 2 points but less than 8 points;

[0114] Ineffective: NHISS score decreased by less than 2 points;

[0115] The results showed that among 100 cases of sequelae of cerebral infarction, 76 were significantly effective, 21 were effective, and 3 were ineffective. The significant effective rate was 76% and the total effective rate was 97%.

[0116] From the above, it can be seen that Example 1 and Example 4 are the best embodiments of the present application.

[0117] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0118] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine preparation for treating sequelae of cerebral infarction, characterized in that: The Chinese medicine preparation comprises the following components in parts by weight: 30-33 parts of Climbing Rock Red, 8-12 parts of Chuanxiong, 6-8 parts of Licorice, 9-14 parts of Astragalus, 10-15 parts of Chrysanthemum, 18-22 parts of Linxiaginseng, 6-8 parts of stir-fried Coix Seed, 10-12 parts of Dioscorea Opposita, 18-19 parts of Uncaria Rhynchophylla, 13-15 parts of Poria, 5-7 parts of stir-fried Euryale ferox, 10-12 parts of stir-fried Lentil, and 8-12 parts of Salvia miltiorrhiza.

2. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 1, characterized in that: The Chinese medicine preparation is specifically composed of the following raw materials by weight: 33 parts of Rhizoma Climbing Rocks, 11 parts of Rhizoma Chuanxiong, 6 parts of Radix Glycyrrhizae, 14 parts of Radix Astragali, 12 parts of Flos Chrysanthemi, 20 parts of Ginseng under the Forest, 8 parts of stir-fried Semen Coix, 12 parts of Dioscorea Oppositae, 18 parts of Rhizoma Uncariae, 15 parts of Poria, 5 parts of stir-fried Euryale ferox, 10 parts of stir-fried Lentils, and 9 parts of Salvia miltiorrhiza.

3. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 1, characterized in that: The Chinese medicine preparation is specifically composed of the following raw materials by weight: 30 parts of Rhizoma Climbing Rocks, 10 parts of Rhizoma Chuanxiong, 6 parts of Radix Glycyrrhizae, 8 parts of Radix Astragali, 12 parts of Flos Chrysanthemi, 10 parts of Ginseng under the Forest, 8 parts of stir-fried Semen Coix, 12 parts of Dioscorea Oppositae, 14 parts of Rhizoma Uncariae, 10 parts of Poria, 5 parts of stir-fried Euryale ferox, 15 parts of stir-fried Lentils, and 11 parts of Radix Salviae Miltiorrhizae.

4. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 1, characterized in that: The dosage forms of the Chinese medicine preparation include oral preparation, powder and pill.

5. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 4, characterized in that: The powdered Chinese medicine preparation comprises the following specific preparation steps: Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust; Step 2: sterilize the raw material pretreated in step 1 with high pressure and high temperature steam for 45 minutes, take out the raw material and dry it until the moisture content is less than 7%; Step 3: The dried raw materials obtained in step 2 are crushed and passed through a 130-mesh sieve. After all the combined drugs are prepared into powder, they are mixed evenly and packaged in fresh-keeping sealed bags at a dosage of 15 g / bag per serving.

6. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 5, characterized in that: The Chinese medicine preparation in pill form comprises the following specific preparation steps: Step 1: Prepare the Chinese medicine powder according to the Chinese medicine preparation method for powder dosage form; Step 2: Add the auxiliary material astragalus honey into the powder and mix thoroughly. The amount of astragalus honey added is 1:1.2 based on the weight of the powder. Heat to 70-80°C during the mixing process; Step 3: Prepare the powder mixed in step 2 at 10 g / pill and package it in small fresh-keeping ziplock bags.

7. A Chinese medicine preparation for treating sequelae of cerebral infarction according to claim 4, characterized in that: The oral dosage form of the Chinese medicine preparation comprises the following specific preparation steps: Step 1: Pre-treat the raw materials of red climbing rock, chuanxiong, licorice, astragalus, chrysanthemum, forest ginseng, fried coix seed, yam, Uncaria rhynchophylla, poria, fried Euryale ferox, fried lentil, and salvia miltiorrhiza to clean up the sand and dust; Step 2: After mixing all the raw materials, add water, control the total weight of the Chinese medicine composition to the amount of water added to be 1g:40-50mL, decoct at 85°C for 1.5h, filter to make tea soup, and sterilize and can.

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