Drug coated balloon of rapamycin loaded metal polyphenol nanoparticles and method of making and use thereof

By using a method to prepare metal polyphenol nanoparticles loaded with rapamycin, the problem of drug loss in drug-coated balloons was solved, achieving efficient drug delivery and targeted therapy, and significantly inhibiting smooth muscle cell proliferation.

CN119950758BActive Publication Date: 2026-06-09SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Filing Date
2025-01-22
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing drug-coated balloons suffer excessive drug loss during delivery and expansion, resulting in low bioavailability of the drug reaching the target lesion vessel wall and limiting treatment efficacy.

Method used

By using metal polyphenol nanoparticles loaded with rapamycin, rapamycin is loaded onto metal-organic framework nanoparticles through a preparation method, and a hollow shell structure of metal polyphenols is formed by etching with tannic acid. Combined with the coating technology of drug-coated balloons, efficient drug delivery is achieved.

Benefits of technology

It achieves high-load, high-stability drug delivery, significantly inhibits smooth muscle cell proliferation, has good biocompatibility and proliferation inhibition effect, and improves the efficiency of drug reaching the target lesion vascular wall.

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Abstract

The application discloses a drug coating balloon of metal polyphenol nanoparticles loaded with rapamycin and a preparation method and application thereof. The application obtains a new generation of drug balloon coating by constructing a functional drug loading system and combining a drug coating balloon coating technology. The metal organic framework nanoparticles realize high loading and high stability of encapsulated rapamycin. The rapamycin is loaded by etching tannic acid to form a metal polyphenol hollow shell structure, and the particle size of the nanoparticles is not obviously affected before and after etching the metal organic framework nanoparticles by tannic acid. The nanoparticles with the metal polyphenol hollow shell structure have good biocompatibility, have an obvious inhibitory effect on the proliferation of smooth muscle cells, and the immunofluorescence staining shows that, under the same drug concentration, compared with a rapamycin group, the metal polyphenol nanoparticle group loaded with rapamycin has a better and excellent inhibitory effect on the proliferation of smooth muscle cells, the smooth muscle cells have more obvious contraction, and the expression amount of specific proteins is less.
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