Catheter pump with oxygen supply function

Abstract

According to the catheter pump with the oxygen supply function, the systemic circulation oxygen supply condition can be improved, the near end of a motor is connected with a catheter, the far end of the motor is coaxially connected with an impeller, the periphery of the impeller is covered with a blood outflow cage, the far end of the blood outflow cage is fixed to the near end of a blood inflow cage through a sleeve, and the far end of the blood inflow cage is further connected with a pigtail pipe; an oxygen supply unit is arranged on the blood outflow cage, and the oxygen supply unit generates oxygen in the ascending aorta on time and on demand according to the physiological signals collected by the sensing unit and releases the oxygen into blood in the ascending aorta. In the heart blood pumping assisting process of the catheter pump, oxygen can be supplemented into blood through the oxygen supply unit, and the whole-body tissue oxygen deficit condition is improved. The oxygen supply unit is integrated on the catheter pump and intervenes through the blood vessel together with the catheter pump, operation is easy, damage to the blood vessel can be reduced, the oxygen supply mode can reduce the risk of gas embolism, oxygen is better distributed, the oxygen supply mode in the physiological state is better met, and recovery of a patient is facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a catheter pump with an oxygen supply function. Background Art

[0002] The catheter pump can be introduced into the heart percutaneously and can be constructed to assist or replace the natural heart pump function by circulating or continuously pumping blood, providing hemodynamic support for cardiogenic shock and acute heart failure. The catheter pump generally includes a motor, the proximal end of the motor is connected to the catheter, and the distal end is connected to the impeller. The motor drives the impeller to rotate and then suck the blood in the ventricle from the blood inflow cage into the cannula, and the blood outflow cage at the proximal end of the cannula flows out into the artery, establishing a left ventricle-ascending aorta drainage pathway.

[0003] For some patients with acute myocardial infarction and cardiogenic shock whose heart's pumping function is sharply weakened, systemic tissue hypoxia may occur. In the existing technology, the catheter pump directly pumps the blood in the ventricle to the ascending aorta. Although it can assist the heart in pumping blood, it cannot replenish oxygen for the human body and cannot quickly improve the hypoxia of systemic tissues. How to achieve this function is a major problem that needs to be solved in the industry. Summary of the invention

[0004] The object of the present invention is to provide a catheter pump with oxygen supply function which can directly improve the oxygen supply of systemic circulation.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a catheter pump with oxygen supply function, including a motor, the proximal end of the motor is connected to the catheter, and the distal end is coaxially connected to an impeller, the outer peripheral cover of the impeller is provided with a blood outflow cage, the distal end of the blood outflow cage is fixed to the proximal end of the blood inflow cage through a sleeve, and the distal end of the blood inflow cage is also connected to a pigtail tube, and the blood outflow cage is provided with an oxygen supply unit, which produces oxygen on time and on demand in the ascending aorta according to the physiological signals collected by the sensor unit and releases oxygen into the blood in the ascending aorta.

[0006] Furthermore, the oxygen supply unit includes a microfluidic chip and an enzyme membrane. The hydrogen peroxide solution enters the microchannel from the liquid guide tube and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane and undergo a chemical reaction to generate and , and Escapes and enters the blood in the ascending aorta.

[0007] Furthermore, the oxygen supply unit includes a microfluidic chip, a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip, and the hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip to generate and , and It escapes from the substrate outlet of the microfluidic chip and enters the blood in the ascending aorta.

[0008] Furthermore, the blood outflow cage is in the shape of a circular tube as a whole, a bleeding window is opened in the proximal section of the circular tube, the microfluidic chip is wrapped on the tube body of the distal section of the circular tube, and the microfluidic chip is an arc-shaped structure that fits the shape of the outer wall of the circular tube, the wall thickness of the circular tube section corresponding to the microfluidic chip is less than the wall thickness of the tube sections on both sides, the outer wall of the microfluidic chip is smoothly connected with the outer walls of the tube sections on both sides, the liquid guide tube is connected to the liquid inlet of the microfluidic chip, the substrate outlet of the microfluidic chip is connected to a microreaction chamber, and the enzyme membrane is arranged in the microreaction chamber.

[0009] Furthermore, the micro-reaction chamber is tubular as a whole, one end of the tube body is connected to the substrate outlet of the microfluidic chip, and the other end is provided with an outlet, the enzyme membrane is arranged in the tube cavity near the outlet, and the enzyme membrane separates the tube cavity, and the catalase is fixed on the membrane sheet near the outlet side.

[0010] Furthermore, the enzyme membrane is placed on a plastic sheet, and the electrode passes through and adheres to the plastic sheet. The enzyme membrane and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid in the microfluidic chip in real time.

[0011] Furthermore, an optical fiber sensor is also provided on the blood outflow cage. The optical fiber sensor includes a sensing head and an optical fiber line. The sensing head is fixed on the pipe section of the blood outflow cage and is axially staggered with the oxygen supply unit.

[0012] Furthermore, the sensing head and the micro-reaction chamber of the oxygen supply unit are arranged along the axial direction of the blood outflow cage, and the sensing head is on the proximal side of the micro-reaction chamber. The peripheral cover of the sensing head and the micro-reaction chamber is provided with a protective cover, and there is a distance between the protective cover and the blood outflow cage for accommodating the sensing head and the micro-reaction chamber.

[0013] Furthermore, the outer wall of the protective cover is constructed as an arc-shaped guide surface extending from the distal end to the proximal end. There is at least one through hole on the flow-facing surface of the arc-shaped guide surface for blood to enter and flush the sensing head. The through hole is opened in the area between the sensing head and the micro-reaction chamber. The through hole is arranged obliquely and the edge is chamfered. A notch is opened at the proximal end of the protective cover for the optical fiber to pass through.

[0014] Furthermore, a plane is arranged on the outer wall of the blood outflow cage along its axial direction, the sensing head and the micro-reaction chamber are fixed on the plane, and both ends of the protective cover are also fixed on the plane.

[0015] Furthermore, a groove is provided on the motor housing, and the optical fiber line and the liquid guide tube pass through the groove and enter the guide tube inside the motor tail. The groove is filled with epoxy resin glue, and the guide tube is also provided with a flushing pipe, an electric cable and a reinforced steel cable.

[0016] In the above scheme, the catheter pump can supplement oxygen into the blood with the oxygen supply unit while assisting the heart in pumping blood, thereby improving systemic tissue hypoxia. The oxygen supply unit is integrated into the catheter pump and is inserted into the blood vessels together with the catheter pump. It is easy to operate and can reduce damage to the blood vessels. At the same time, the oxygen supply unit produces oxygen in situ and on demand in the blood vessels, that is, we produce oxygen in situ in the blood vessels according to the amount of oxygen needed in the blood. This oxygen supply method can reduce the risk of gas embolism, make oxygen better distributed, and be more in line with the oxygen supply mode under physiological conditions, which is conducive to the patient's recovery. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of the overall structure of the catheter pump in Example 1; Figure 2 for Figure 1 Schematic diagram of the structure after removing the catheter and pigtail tube; Figure 3 Schematic diagram of the structure of the blood outflow cage and the oxygen supply unit in Example 1 Figure 1 ; Figure 4 Schematic diagram of the structure of the blood outflow cage and the oxygen supply unit in Example 1 Figure 2 ; Figure 5 This is a schematic diagram of the structure of the blood outflow cage in Example 1; Figure 6 This is a planar development schematic diagram of the oxygen supply unit in Example 1; Figure 7 for Figure 6 The middle part is an enlarged schematic diagram; Figure 8 Schematic diagram of the structure of the microfluidic chip in Example 1; Fig. 9 for Figure 1 Middle AA section view; Fig.10 This is a planar development schematic diagram of the oxygen supply unit in Example 2; Fig.11 This is a schematic diagram of the catheter pump in use. DETAILED DESCRIPTION

[0018] To facilitate understanding, let us first define the direction: "proximal" and "proximal side" refer to the side close to the operator / doctor, and "distal" and "distal side" refer to the side away from the operator / doctor, that is, the side close to the heart. Figure 1-Figure 11 The invention is further described in detail.

[0019] like Figure 1 , Figure 2 As shown, a catheter pump with oxygen supply function includes a motor 10, the proximal end of the motor 10 is connected to the catheter 20, and the distal end is coaxially connected to an impeller, a blood outflow cage 30 is provided on the outer peripheral cover of the impeller, the distal end of the blood outflow cage 30 is fixed to the proximal end of the blood inflow cage 50 through a sleeve 40, and the distal end of the blood inflow cage 50 is also connected to a pigtail tube 60, and the blood outflow cage 30 is provided with an oxygen supply unit 70, and the oxygen supply unit 70 produces oxygen in the ascending aorta on time and on demand according to the physiological signals collected by the sensor unit and releases oxygen into the blood in the ascending aorta.

[0020] In the above scheme, the catheter pump is inserted into the ventricle through the blood vessels. At this time, the pigtail tube 60, the blood inflow cage 50 and part of the sleeve 40 are located in the left ventricle, the sleeve 40 crosses the aortic valve, and part of the sleeve, the blood outflow cage 30 and the motor 10 are located in the ascending aorta. The motor 10 drives the impeller to rotate and pumps the blood in the left ventricle into the aorta, and then participates in the systemic circulation. In the process of assisting the heart to pump blood, the catheter pump can also use the oxygen supply unit 70 to supplement oxygen into the blood, thereby improving the situation of systemic tissue hypoxia. Here, the oxygen supply unit 70 is integrated on the catheter pump, and is inserted through the blood vessels together with the catheter pump. The operation is simple and can reduce damage to the blood vessels. At the same time, the oxygen supply unit 70 produces oxygen on time and on demand in the blood vessels, that is, how much oxygen is needed in the blood and when oxygen is needed, we produce how much oxygen in situ in the blood vessels and when oxygen is needed.

[0021] Compared with the method of directly introducing oxygen into the blood vessels, in situ oxygen generation has the following beneficial effects: 1. Reduce the risk of gas embolism: When oxygen is directly introduced into blood vessels, bubbles may form in the blood circulation of the gas machine, causing gas embolism, hindering the normal flow of blood, leading to local tissue ischemia, hypoxia, and even life-threatening. In situ oxygen generation generates oxygen inside the blood vessels, rather than direct gas perfusion, which can greatly reduce the risk of gas embolism.

[0022] 2. Better oxygen distribution: Directly supplying oxygen into the blood vessels makes it difficult to control the distribution of oxygen because the gas in the blood vessels mainly flows with the blood flow, which may cause local oxygen concentration to be too high or too low. Intravascular in situ oxygen production can produce oxygen closer to the location where tissues need it (here, the ascending aorta), allowing oxygen to be more accurately distributed around the tissues and improving oxygen utilization efficiency.

[0023] 3. An oxygen supply mode that is more in line with physiological conditions: Under normal physiological conditions, oxygen is exchanged through alveolar gases, and then carried by hemoglobin in the blood and transported to tissues throughout the body. Intravascular in situ oxygen production can simulate this more continuous and stable oxygen supply method, rather than the more abrupt gas input like direct ventilation. It can produce and supply oxygen more reasonably in the blood vessels based on the actual oxygen demand of local tissues, which is more in line with physiological needs.

[0024] Another key point of the present invention is to directly supplement oxygen into the ascending aorta. This arrangement also has the following beneficial effects: 1. Directly improve the oxygen supply of systemic circulation: The ascending aorta is the starting point of systemic circulation. Supplementing oxygen from here can allow oxygen-rich blood to quickly enter the arterial system of the whole body. This is like opening a "fast track" for systemic circulation, which can quickly improve the oxygen supply of tissues throughout the body.

[0025] 2. Reduce the relative proportion of myocardial oxygen consumption: Since the supplemented oxygen can improve the oxygen supply of the whole body to a certain extent after entering the systemic circulation, the "demand pressure" of other organs for oxygen carried by the heart's pumping blood will be reduced. This allows the heart's own work to maintain oxygen supply to other organs to be appropriately reduced, thereby reducing myocardial oxygen consumption to a certain extent.

[0026] 3. Less impact on pulmonary circulation: This method is mainly aimed at supporting systemic circulation, and has relatively little interference with the hemodynamics and gas exchange process of the pulmonary circulation itself. Because the blood flow and gas exchange pattern inside the heart are not directly changed, the parameters such as pressure and flow of the pulmonary circulation will not change dramatically due to the supplementation of oxygen in the ascending aorta. Example 1

[0027] In order to achieve on-demand oxygen production, it is hoped that hydrogen peroxide and catalase can react in small amounts at a time to produce small amounts of In order to achieve the above purpose, the oxygen supply unit 70 includes a microfluidic chip 71 and an enzyme membrane 72. The hydrogen peroxide solution enters the microchannel from the liquid guide tube 73 and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane 72 and react chemically to generate and , and Escapes and enters the blood in the ascending aorta. Here, hydrogen peroxide and catalase react to produce oxygen. The product of the reaction is and ,in Mixed into the ascending aorta blood, oxygenating the blood. It is also needed by the human body, so it will not cause any harm to the human body.

[0028] Membranes are good carriers for enzyme immobilization. Compared with common chemical reactions, the rate of hydrogen peroxide enzymatic reaction is fast and In the catalytic process, the higher the concentration of catalase, The faster the catalysis occurs, the higher the concentration of catalase. Therefore, we fix the catalase on the membrane to ensure the high concentration of catalase. The microfluidic chip 71 is made of a flexible material such as polydimethylsiloxane---PDMS, and is provided with a microchannel. The size of the microchannel is in the micrometer or even nanometer level, which can accurately control the reaction amount. The technology of the microfluidic chip 71 that can separate the hydrogen peroxide solution into microdroplets is a well-known technology and will not be described in detail here. After the hydrogen peroxide solution passes through the microchannel, it is separated into microdroplets arranged in a spaced manner, or even separated hydrogen peroxide molecules. Then, when the hydrogen peroxide molecules pass through the enzyme membrane 72, they react quickly with the enzyme to obtain Supply oxygen to the blood.

[0029] In order to achieve the above purpose, we use a microfluidic chip 71 to control the amount of hydrogen peroxide. The microfluidic chip 71 can achieve precise control of the fluid through microchannels and other functional components. Due to the setting of the microchannel, the micro-transport of the fluid is achieved, thereby achieving the purpose of in-situ oxygen production; the concentration of catalase on the enzyme membrane 72 is high, and a chemical reaction will occur the moment the hydrogen peroxide molecules come into contact with the enzyme membrane 72, thereby achieving the purpose of timely oxygen supply; through computer programming control, the transmission, mixing and separation of microdroplets in the channel can be accurately achieved, thereby achieving quantitative oxygen production.

[0030] Since the catheter pump is inserted through the blood vessels, it is limited by the diameter of the blood vessels, and the oxygen supply unit 70 needs to be reasonably arranged to meet the requirements of the blood vessel insertion. Figure 3-Figure 8The blood outflow cage 30 is in the shape of a circular tube as a whole, and a bleeding window 31 is provided at the proximal section of the circular tube. The microfluidic chip 71 is wrapped on the tube body of the distal section of the circular tube, and the microfluidic chip 71 is an arc-shaped structure that fits the outer wall of the circular tube. The wall thickness of the circular tube section corresponding to the microfluidic chip 71 is less than the wall thickness of the tube sections on both sides. The outer wall of the microfluidic chip 71 is smoothly connected with the outer walls of the tube sections on both sides. The liquid guide tube 73 is connected with the liquid inlet of the microfluidic chip 81. The substrate outlet of the microfluidic chip 71 is connected with a micro-reaction chamber 74, and the enzyme membrane 72 is arranged in the micro-reaction chamber 74. The microfluidic chip 71 is made of a substrate with soft properties, such as PMDS material, to adapt to the surface shape of the blood outflow cage 30. On the one hand, the outer diameter of the catheter pump is reduced, and on the other hand, the contact area between the microfluidic chip 71 and the surface of the blood outflow cage 30 is enhanced, and the reliability of the connection is improved. The two can be fixed by gluing. The wall thickness of the circular tube segment corresponding to the microfluidic chip 71 is smaller than the wall thickness of the tube segments on both sides. That is to say, there is an annular groove on the tube wall for installing the microfluidic chip 71. The outer wall of the microfluidic chip 71 is smoothly connected with the outer walls of the tube segments on both sides. From the outside, the outer diameters are similar or equal, thereby reducing the damage to the blood vessels caused by the catheter pump during intervention and withdrawal.

[0031] The micro-reaction chamber 74 is tubular in shape, i.e., a micro-channel reaction chamber with a small volume. One end of the tube body is connected to the substrate outlet of the microfluidic chip 71, and the other end is provided with an outlet 741. The enzyme membrane 72 is provided in the tube cavity near the outlet, and the enzyme membrane 72 separates the tube cavity. The catalase is fixed on the membrane sheet on the side near the outlet 741. That is to say, when hydrogen peroxide passes through the membrane sheet and reaches the other side, it can react chemically with the enzyme, and the generated and It no longer needs to pass through the diaphragm, so it can enter the blood more quickly and combine with the hemoglobin in the blood vessels that is lacking oxygen at that moment, so as to achieve the purpose of timely and on-demand oxygen supply. A one-way valve / diaphragm structure can also be set at the outlet 741 to only allow and Alternatively, the enzyme membrane 72 allows hydrogen peroxide to pass easily, and blood, and Impassable material.

[0032] Furthermore, the enzyme membrane 72 is placed on a plastic sheet (shown in the figure), and an electrode (not shown in the figure) passes through and is bonded to the plastic sheet. The enzyme membrane 72 and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide solution of the microfluidic chip 71 in real time. At the same time, the enzymatic current sensor can also detect the generation of chemical reactions. Concentration, real-time response Hydrogen peroxide undergoes a dismutation reaction with catalase attached to the membrane:

[0033] In this way, the two The molecules encounter CAT successively and collide with the active center, and a disproportionation reaction occurs to generate two molecules and a molecular.

[0034] When the catheter pump is working, it is necessary to monitor its working status in real time, including key parameters such as flow rate and pressure. Therefore, an optical fiber sensor 80 is also provided on the blood outflow cage 30. Through optical fiber transmission technology, the optical fiber sensor 80 feeds back the detected data to the control system in real time, so that the operator can understand the working status of the catheter pump in time and make corresponding adjustments and optimizations. The optical fiber sensor 80 includes a sensor head 81 and an optical fiber line 82. The sensor head 81 is fixed on the pipe section of the blood outflow cage 30 and is axially staggered with the oxygen supply unit 70 to avoid affecting the measurement accuracy of the sensor head 81.

[0035] During the process of transvascular intervention of the catheter pump, the tortuous path and / or calcified anatomical structure may hinder and damage the sensing head 81 and the micro-reaction chamber 74. Therefore, the sensing head 81 and the micro-reaction chamber 74 of the oxygen supply unit 70 are arranged along the axial direction of the blood outflow cage 30, and the sensing head 81 is on the proximal side of the micro-reaction chamber 74. In this way, the sensing head 81 can be arranged axially in the micro-reaction chamber 74. The peripheral cover of the sensing head 81 and the micro-reaction chamber 74 is provided with a protective cover 83, and there is a distance between the protective cover 83 and the blood outflow cage 30 for accommodating the sensing head 81 and the micro-reaction chamber 74. The same protective cover 83 can be used to effectively protect the sensor head 81 and the micro-reaction chamber 74 from damage. Compared with the method of independently setting the protective cover 83 on the sensor head 81 and the micro-reaction chamber 74, it has the following beneficial effects: (1) less damage to the blood vessels during the intervention and withdrawal process; (2) a protective cover 83 has a large axial length, and a large space between it and the blood outflow cage 30, which can reduce blood retention and reduce the formation of thrombus; (3) a protective cover 30 causes little damage to the blood; (4) a protective cover 83 only needs to be welded once, which is simple to operate.

[0036] Taking into account the convenience of insertion into the blood vessel and the low damage to the blood vessel, the outer wall of the protective cover 83 is constructed as an arc-shaped guide surface 831 extending from the distal end to the proximal end. There is at least one through hole 832 on the frontal surface of the arc-shaped guide surface 831 for blood to enter and flush the sensing head 81. The through hole 832 is provided in the area between the sensing head 81 and the micro-reaction chamber 74. The through hole 832 is arranged obliquely and the edge is chamfered to reduce blood damage. The proximal end of the protective cover 83 is provided with a notch 833 for the optical fiber line 82 to pass through. The distal end of the protective cover 83 with this C-shaped structure has no notch to prevent blood from directly impacting the micro-reaction chamber 74 and avoid obstruction to oxygen release. The two sides of the protective cover 83 are open, so that blood can flow out smoothly, preventing blood from stagnating and forming thrombi, and also facilitating the generation of oxygen by the oxygen supply unit 70. and In order to ensure the accuracy of the signal acquisition of the sensor head 81, a through hole 832 is provided on the flow-facing surface of the arc-shaped guide surface 831 in the area between the sensor head 81 and the micro-reaction chamber 74 (for the outer surface of the C-shaped protective cover 83, the highest point is used as the boundary, the distal part is the flow-facing surface, and the proximal part is the drainage surface), and the through hole 832 is arranged obliquely, thereby guiding the blood flow to directly flush the proximal sensor head 81, while not flushing the distal micro-reaction chamber 74.

[0037] Since the outer circumference of the blood outflow cage 30 is a smooth circumferential surface, a plane 32 is provided on the outer wall of the blood outflow cage 30 along its axial direction, and the sensing head 81 and the micro-reaction chamber 74 are fixed on the plane 32, and the two ends of the protective cover 83 are also fixed on the plane 32. The plane 32 provides a reliable installation position for the sensing head 81, the micro-reaction chamber 74 and the protective cover 83, ensures the firmness of the connection, and further improves the safety and reliability of the entire catheter pump. Example 2

[0038] like Fig.10 As shown, the oxygen supply unit 70 includes a microfluidic chip 71, a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip 71, and the hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip 71 to generate and , and Escape from the substrate outlet of the microfluidic chip 71 and enter the blood of the ascending aorta. In this embodiment, two liquid inlet pipes are set to transport hydrogen peroxide and catalase respectively, so there is no need to set structures such as enzyme membranes, and even the micro reaction chamber 74 can be set on the microfluidic chip 71 without additional settings. We use the microfluidic chip 71 to control the amount of hydrogen peroxide and catalase. The microfluidic chip 71 can accurately control the fluid through microchannels, reaction chambers and other functional components, and can accurately realize the transmission, mixing and separation of micro droplets in the channel, thereby realizing quantitative oxygen production. Compared with Example 1, the present embodiment can omit the enzyme membrane unit and the additional micro reaction chamber structure, so that the volume is reduced. But correspondingly, the design inside the microfluidic chip is also relatively complicated, and two liquid inlet pipes are required, and the lead-out design of the liquid inlet pipe is also more complicated.

[0039] A groove is provided on the housing of the motor 10, and the optical fiber line 82 and the catheter 73 pass through the groove and enter the catheter 20 from the rear end of the motor 10. The groove is filled with epoxy resin glue, and the optical fiber line 82 and the catheter 73 are clamped in the groove and fixed with epoxy resin glue and the groove is filled, thereby ensuring the flatness and smoothness of the surface of the motor 10 housing, and further reducing damage to blood vessels or other tissues during the intervention process. It should be noted that the optical fiber line 82 and the catheter 73 are respectively arranged in different grooves, and finally merge into the catheter 20 through the groove at the rear end of the motor 10. When the catheter 20 and the rear end of the motor 10 are fixed by a fixing ring, the positions of the optical fiber line 82 and the catheter 73 are also limited. Figure 8 As shown, a flushing tube 21, a cable 22 and a reinforced steel cable 23 are also provided in the catheter 20. The optical fiber 82 is used to transmit optical signals, the liquid guide tube 73 is used to deliver hydrogen peroxide solution, the flushing tube 21 is used to deliver flushing liquid to prevent blood from entering the motor 10 to form thrombus, the cable 22 is used to power the motor 10, and the reinforced steel cable 23 is used to enhance the rigidity of the catheter 20 so that it can push the catheter pump into the designated position.

[0040] The design of the above oxygen supply unit can also be applied to right ventricular catheter pumps, foldable blood pumps and IABP devices to supplement oxygen to different locations in the human body.

[0041] Of course, it is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, but also includes the same or similar structures that can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-limiting, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any reference numerals in the claims should not be regarded as limiting the claims involved.

[0042] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A catheter pump with an oxygen supply function, comprising a motor (10), wherein the proximal end of the motor (10) is connected to a catheter (20), and the distal end is coaxially connected to an impeller, a blood outflow cage (30) is provided on the outer periphery of the impeller, the distal end of the blood outflow cage (30) is fixed to the proximal end of the blood inflow cage (50) through a sleeve (40), and the distal end of the blood inflow cage (50) is further connected to a pigtail tube (60), characterized in that: The blood outflow cage (30) is provided with an oxygen supply unit (70), which produces oxygen in the ascending aorta on time and on demand according to the physiological signals collected by the sensor unit and releases the oxygen into the blood in the ascending aorta.

2. The catheter pump with oxygen supply function according to claim 1, characterized in that: The oxygen supply unit (70) includes a microfluidic chip (71) and an enzyme membrane (72). The hydrogen peroxide solution enters the microchannel from the liquid guide tube (73) and separates into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane (72) and undergo a chemical reaction to generate and , and escapes and enters the bloodstream in the ascending aorta.

3. The catheter pump with oxygen supply function according to claim 1, characterized in that: The oxygen supply unit (70) includes a microfluidic chip (71), a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip (71), and the hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip (71) to generate and , and It escapes from the substrate outlet of the microfluidic chip (71) and enters the blood in the ascending aorta.

4. The catheter pump with oxygen supply function according to claim 2, characterized in that: The blood outflow cage (30) is in the shape of a circular tube as a whole, and a bleeding window (31) is opened in the proximal section of the circular tube. The microfluidic chip (71) is wrapped on the tube body of the distal section of the circular tube, and the microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the circular tube. The wall thickness of the circular tube section corresponding to the microfluidic chip (71) is less than the wall thickness of the tube sections on both sides. The outer wall of the microfluidic chip (71) is smoothly connected with the outer walls of the tube sections on both sides. The liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71). The substrate outlet of the microfluidic chip (71) is connected to a micro reaction chamber (74), and the enzyme membrane (72) is arranged in the micro reaction chamber (74).

5. The catheter pump with oxygen supply function according to claim 4, characterized in that: The micro-reaction chamber (74) is tubular as a whole, one end of the tube body is connected to the substrate outlet of the microfluidic chip (71), and the other end is provided with an outlet (741). The enzyme membrane (72) is provided in the inner cavity of the tube near the outlet, and the enzyme membrane (72) separates the inner cavity of the tube. The catalase is fixed on the membrane sheet near the side of the outlet (741). The enzyme membrane (72) is placed on the plastic sheet, and the electrode passes through and adheres to the plastic sheet. The enzyme membrane (72) and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects the current signal and feeds it back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid of the microfluidic chip (71) in real time.

6. The catheter pump with oxygen supply function according to claim 4, characterized in that: The blood outflow cage (30) is also provided with an optical fiber sensor (80), which includes a sensing head (81) and an optical fiber line (82). The sensing head (81) is fixed to the pipe section of the blood outflow cage (30) and is axially displaced from the oxygen supply unit (70).

7. The catheter pump with oxygen supply function according to claim 6, characterized in that: The sensing head (81) and the micro-reaction chamber (74) of the oxygen supply unit (70) are arranged along the axial direction of the blood outflow cage (30), and the sensing head (81) is on the proximal side of the micro-reaction chamber (74). The outer peripheral cover of the sensing head (81) and the micro-reaction chamber (74) is provided with a protective cover (83), and a distance is provided between the protective cover (83) and the blood outflow cage (30) for accommodating the sensing head (81) and the micro-reaction chamber (74).

8. The catheter pump with oxygen supply function according to claim 7, characterized in that: The outer wall of the protective cover (83) is constructed as an arc-shaped guide surface (831) extending from the distal end to the proximal end. The upstream surface of the arc-shaped guide surface (831) has at least one through hole (832) for blood to enter and flush the sensing head (81). The through hole (832) is opened in the area between the sensing head (81) and the micro-reaction chamber (74). The through hole (832) is arranged obliquely and the edge position is chamfered. The proximal end of the protective cover (83) is provided with a notch (833) for the optical fiber (82) to pass through.

9. The catheter pump with oxygen supply function according to claim 6, characterized in that: A plane (32) is provided on the outer wall of the blood outflow cage (30) along its axial direction. The sensor head (81) and the micro-reaction chamber (74) are fixed on the plane (32). Both ends of the protective cover (83) are also fixed on the plane (32).

10. The catheter pump with oxygen supply function according to claim 1, characterized in that: A groove is provided on the housing of the motor (10), and the optical fiber line (82) and the liquid guide tube (73) pass through the groove and enter the in-machine guide tube (20) at the tail of the motor (10). The groove is filled with epoxy resin glue, and the guide tube (20) is also provided with a flushing tube (21), an electric cable (22) and a reinforced steel cable (23).

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