Dyeing device

Abstract

The invention discloses a dyeing device which comprises a feeding assembly, a dyeing mechanism and a discharging assembly. The feeding assembly is used for turning over a single slide by 180 degrees and feeding the single slide into the dyeing mechanism. The dyeing mechanism is used for dyeing the slide to obtain a dyed slide; and the discharging assembly is used for turning over the dyed pieces by 180 degrees and discharging the dyed pieces. According to the dyeing device provided by the invention, the feeding and discharging problems of the front and rear slides of the dyeing tank are solved, a good dyeing effect is realized, and the automation degree of dyeing is improved.

Description

Technical Field

[0001] The present application relates to the technical field of detection equipment, and in particular to a dyeing device.

[0002] This patent application claims the priority of Chinese patent applications CN202323018334.5 and CN202323546673.0, the contents of which are incorporated herein by reference. Background Art

[0003] In the field of medical testing, staining is an experimental method that uses one or more dyes to stain the tissues and intracellular structures of the sample to be tested. The stained sample can clearly observe the internal structure of the cell under a microscope, which is conducive to making correct clinical diagnosis.

[0004] The existing sample staining is divided into manual staining and automatic staining. Manual staining has high requirements on the operator and low manual operation efficiency, which is not suitable for the needs of large-scale specimen inspection. Automatic staining of the device is completed by the mechanical structure of the device cooperating with each other to move the slide and stain the operation.

[0005] However, the current automatic staining device can only drive and stain the slide after it has been placed in place, and the slide needs to be removed manually after staining. There are still problems with the connection between the previous and subsequent processes, and the degree of automation is low, which cannot meet the needs of clinical testing. Summary of the invention

[0006] In order to solve the above-mentioned technical problems, the first purpose of the present invention is to provide a staining device; the staining device provided in the present application solves the problem of feeding and discharging the glass slides in front and behind the staining pool, achieves good staining effects, and improves the degree of automation of staining.

[0007] The technical solution provided by the present invention is as follows: A dyeing device, comprising: a feeding component, a dyeing mechanism, and a discharging component. The feeding assembly is used to flip a single glass slide 180 degrees and feed it into the staining mechanism; The dyeing mechanism is used to dye the slide to obtain a dyed slide; The discharging assembly is used to turn the dye sheet 180 degrees and discharge the dye sheet.

[0008] Preferably, the feed assembly comprises a slide turning mechanism, and the slide turning mechanism comprises a slide turning clamp and a slide turning power source; the slide turning clamp is connected to the power output shaft of the slide turning power source and rotates therewith, and the slide turning clamp is also provided with at least one set of slide clamping claws; The discharging assembly includes a dye sheet turning mechanism, which includes a dye sheet turning clamp and a dye sheet turning power source; the dye sheet turning clamp is connected to the power output shaft of the dye sheet turning power source and rotates therewith, and the dye sheet turning clamp is also provided with at least one set of dye sheet clamps.

[0009] Preferably, the height of the slide clamp when the slide flipping mechanism is facing away from the staining mechanism is lower than the height of the slide clamp when the slide flipping mechanism is rotated to face the staining mechanism; The height of the dye sheet clamping claw when the dye sheet turning mechanism faces the dyeing mechanism is lower than the height of the dye sheet clamping claw when the dye sheet turning mechanism rotates to face away from the dyeing mechanism.

[0010] Preferably, the feed assembly further comprises a slide box moving mechanism and a slide pushing mechanism, wherein the slide box moving mechanism drives the slide box to a target position, and the slide pushing mechanism is used to push out a single slide in the slide box; The discharging assembly also includes a dye sheet box moving mechanism and a dye sheet pushing mechanism. The dye sheet box moving mechanism drives the dye sheet box to a target position, and the dye sheet pushing mechanism is used to push the dye sheet back to the target position in the sheet storage box.

[0011] Preferably, the slide pushing mechanism pushes the slide to the slide guide rail, and the slide guide rail has a first groove for the slide clamp to fall into; The dye sheet pushing mechanism pushes the dye sheet flipped and placed by the dye sheet flipping mechanism on the dye sheet guide rail, and the dye sheet guide rail has a second groove for the dye sheet clamping claw to fall into.

[0012] Preferably, the dye box moving mechanism comprises a dye box tray, a dye box guide rail and a dye box moving power source, the dye box tray is slidably connected to the dye box guide rail, and the dye box moving power source drives the dye box tray to move.

[0013] Preferably, the dyeing box moving mechanism further includes a dyeing box switching mechanism; The dye box tray has at least two installation positions for dye boxes; the dye box switching mechanism is used to push the dye box tray to switch the dye boxes.

[0014] Preferably, the slide pushing mechanism comprises a slide push rod, a slide pushing guide rail and a slide pushing power source; the slide push rod is slidably connected to the slide pushing guide rail, and the slide pushing power source drives the slide push rod to move; The dye sheet pushing mechanism includes a dye sheet pushing rod, a dye sheet pushing guide rail and a dye sheet pushing power source; the dye sheet pushing rod is slidably connected to the dye sheet pushing guide rail, and the dye sheet pushing power source drives the dye sheet pushing rod to move. Preferably, the dyeing device includes a shell, the dyeing mechanism is detachably arranged in the shell, and the feeding assembly and the discharging assembly are located at both ends of the dyeing mechanism; An initial position is set between the staining mechanism and the feeding assembly for the feeding assembly to flip the slide; An end point is set between the dyeing mechanism and the discharging component for the discharging component to turn over the dyed sheet.

[0015] Preferably, the staining mechanism is any one of a Gram staining mechanism, a fluorescent staining mechanism or a Regis staining mechanism.

[0016] Preferably, when the dyeing mechanism is a Gram dyeing mechanism, the dyeing mechanism includes, from the initial position end to the terminal position end, a primary dyeing position, a washing position 1, a mordanting position, a washing position 2, a bleaching position, a washing position 3, a re-dyeing position, and a washing position 4 in sequence; When the dyeing mechanism is a fluorescent dyeing mechanism, the dyeing mechanism includes a fixing position, a buffer solution washing position, a scraping position, a dyeing liquid position, and a cleaning position from the initial position end to the terminal position end; When the dyeing mechanism is a Regis dyeing mechanism, the dyeing mechanism includes an A liquid dyeing position, a B liquid dyeing position, and a cleaning position in sequence from the initial position end to the terminal position end.

[0017] Preferably, the dyeing mechanism is further provided with a scraping position and a drying position upstream of the terminal position; or, the dyeing mechanism is provided with a scraping position upstream of the terminal position, and a drying mechanism is arranged at the terminal position.

[0018] The present application provides a dyeing device, including a feeding component, a dyeing mechanism, and a discharging component. The feeding component is used to flip a glass slide 180° and feed it into the dyeing mechanism; the dyeing mechanism is used to dye the glass slide to obtain a dyed slide; the discharging component is used to flip the dyed slide 180° and discharge the slide. The dyeing device provided by the present application uses the feeding component to flip a batch of glass slides to be dyed one by one by 180° in sequence, so that the side of the glass slide carrying the sample turns from upward to downward, so that the side of the glass slide carrying the sample is fully contacted with the working liquid such as the dye in the dyeing mechanism to achieve dyeing, and a dyed glass slide (referred to as a dyed slide) is obtained; then the dyed slide is flipped again by the discharging component, and the side of the glass slide carrying the sample is flipped upward again, and the slide is discharged.

[0019] The staining device provided by the present application solves the problem of feeding and discharging glass slides in front and behind the staining tank, converts batches of glass slides into single-piece output, and ensures the staining effect of each glass slide; at the same time, by flipping the feeding and discharging operations by 180°, the glass slides and dyeing slides are stored in accordance with the conventional storage habit of the sample facing up in the field, and the sample can be faced down during staining, which is convenient for full contact with the working liquid such as the dye solution in the staining tank, thereby achieving a good staining effect and improving the degree of automation of staining. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 It is a structural schematic diagram of a dyeing device in an embodiment of the present invention; Figure 2 for Figure 1 Schematic diagram from top view; Figure 3 Schematic diagram of the structure of the slide turning mechanism in an embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of the dye sheet turning mechanism in an embodiment of the present invention; Figure 5 It is a structural schematic diagram of the dyeing box moving mechanism in an embodiment of the present invention; Figure 6 It is a structural schematic diagram of the dyeing film box moving mechanism in an embodiment of the present invention (with a film storage box switching mechanism, and the film storage box tray has two installation positions); Figure 7 It is a structural schematic diagram of a slide pushing mechanism in an embodiment of the present invention; Figure 8 This is a structural schematic diagram of a dye sheet pushing mechanism in an embodiment of the present invention; Fig. 9 Schematic top view of the dyeing mechanism in an embodiment of the present invention; Fig.10 This is a schematic diagram of the structure of the Gram staining platform in an embodiment of the present invention; Fig.11 This is a schematic diagram of the structure of the fluorescent staining platform in an embodiment of the present invention; Fig.12 Schematic diagram of the structure of the Ruiji dyeing platform in an embodiment of the present invention; Fig.13 It is a structural schematic diagram of a dyeing device in an embodiment of the present invention being located in a dyeing apparatus; Fig.14 for Fig.13 A schematic diagram of the structure of the dyeing apparatus from another angle (part of the shell is removed); Fig.15 for Fig.14 A partial enlarged schematic diagram (the dye sheet flipping clamp shows two positions at the same time); Fig.16 A partial enlarged schematic diagram of another position of the staining instrument (the slide flip clamp shows two positions at the same time); Fig.17A schematic top view of a dyeing mechanism that can be used in an embodiment of the present invention (the carrier driving mechanism is not shown); Fig.18 A structural schematic diagram of a dyeing mechanism that can be used in an embodiment of the present invention (the bottom plate only shows part of it); Fig.19 for Fig.18 A partial enlarged schematic diagram of Fig. 20 for Fig.18 A partial enlarged schematic diagram of another location; Fig.21 for Fig.18 A top view schematic diagram of Fig. 22 An exploded schematic diagram of a dyeing mechanism that can be used in an embodiment of the present invention (the carrier driving mechanism is not shown); Fig.23 for Fig.17 AA section view; Fig.24 for Fig.23 A partial enlarged schematic diagram of Fig.25 A schematic diagram of the structure of a drying component that can be used in an embodiment of the present invention; Fig.26 A schematic side view of a drying component that can be used in an embodiment of the present invention; Fig. 27 Schematic diagram of another structure of a dyeing mechanism that can be used in an embodiment of the present invention (the transmission structure used by the carrier driving mechanism is a screw); Fig.28 It is a schematic diagram of a transmission belt structure with pillars that can be used in the transmission structure in an embodiment of the present invention.

[0022] Figure numerals: 1-slide flipping mechanism; 11-slide flipping clamp; 111-slide clamping claw; 12-slide flipping power source; 2-slide flipping mechanism; 21-slide flipping clamping member; 211-slide clamping claw; 22-slide flipping power source; 3-slide box moving mechanism; 4-slide pushing mechanism; 41-slide push rod; 42-slide pushing guide rail; 43-slide pushing power source; 5-slide box moving mechanism; 51-slide box tray; 52-slide box guide rail; 53-slide box moving power source; 54-slide box switching mechanism; 6-slide pushing mechanism; 61-slide push rod; 62-slide pushing guide rail; 63-slide pushing power source; 7-slide flipping guide rail; 71-first groove; 8-slide flipping guide rail; 81-second groove.

[0023] a1-base; a11-liquid flow channel; a2-staining platform; a21-reagent output slot; a211-reagent output hole; a22-liquid guide slot; a3-carrier support structure; a4-carrier drive mechanism; a41-drive transmission structure; a5-cleaning component; a51-liquid outlet hole; a52-base; a53-cleaning liquid output structure; a6-drying structure; a61-drying component; a611-air guide tube; a612-fan; a62-wiping component; a621-wiping protrusion; a7-bottom plate; a71-through hole; a72-sealing ring; a73-annular groove; a74-locating pin; a75-locating depression; a8-level gauge. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0025] It should be noted that when an element is referred to as being "fixed on" or "set on" another element, it can be directly on the other element or indirectly set on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0026] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0027] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, "multiple" and "several" mean two or more, unless otherwise clearly and specifically defined.

[0028] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the conditions under which this application can be implemented. Therefore, they have no substantive technical significance. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical content disclosed in this application without affecting the effects and purposes that can be achieved by this application.

[0029] As shown in the figure, an embodiment of the present invention provides a dyeing device, including: a feeding component, a dyeing mechanism, and a discharging component. The feeding assembly is used to flip a single glass slide 180 degrees and feed it into the staining mechanism; The dyeing mechanism is used to dye the slide to obtain a dyed slide; The discharging assembly is used to turn the dye sheet 180 degrees and discharge the dye sheet.

[0030] The present application provides a dyeing device, including a feeding component, a dyeing mechanism, and a discharging component. The feeding component is used to flip a glass slide 180° and feed it into the dyeing mechanism; the dyeing mechanism is used to dye the glass slide to obtain a dyed slide; the discharging component is used to flip the dyed slide 180° and discharge the slide. The dyeing device provided by the present application uses the feeding component to flip a batch of glass slides to be dyed one by one by 180° in sequence, so that the side of the glass slide carrying the sample turns from upward to downward, so that the side of the glass slide carrying the sample is fully contacted with the working liquid such as the dye in the dyeing mechanism to achieve dyeing, and a dyed glass slide (referred to as a dyed slide) is obtained; then the dyed slide is flipped again by the discharging component, and the side of the glass slide carrying the sample is flipped upward again, and the slide is discharged.

[0031] The staining device provided by the present application solves the problem of feeding and discharging glass slides in front and behind the staining tank, converts batches of glass slides into single-piece output, and ensures the staining effect of each glass slide; at the same time, by flipping the feeding and discharging operations by 180°, the glass slides and dyeing slides are stored in accordance with the conventional storage habit of the sample facing up in the field, and the sample can be faced down during staining, which is convenient for full contact with the working liquid such as the dye solution in the staining tank, thereby achieving a good staining effect and improving the degree of automation of staining.

[0032] In the present application, the stained slide refers to the slide after staining. The structure of the slide itself has not changed, and it is only distinguished for the convenience of description.

[0033] Preferably, the feeding assembly includes a glass slide turning mechanism 1, and the glass slide turning mechanism 1 includes a glass slide turning clamp 11 and a glass slide turning power source 12; the glass slide turning clamp 11 is connected to the power output shaft of the glass slide turning power source 12 and rotates therewith, and the glass slide turning clamp 11 is also provided with at least one set of glass slide clamping claws 111; The discharging assembly includes a dye sheet turning mechanism 2, which includes a dye sheet turning clamp 21 and a dye sheet turning power source 22; the dye sheet turning clamp 21 is connected to the power output shaft of the dye sheet turning power source 22 and rotates therewith, and the dye sheet turning clamp 21 is also provided with at least one set of dye sheet clamps 211.

[0034] In the present application, the dyeing mechanism can drive the slide to move while dyeing, or it can remain stationary. When remaining stationary, one of the feed assembly and the discharge assembly needs to be able to retract, so that the slide can be alternately fixed by the feed assembly and the discharge assembly to achieve flipping. More preferably, the dyeing mechanism can drive the slide to move while dyeing, then the feed assembly places the slide at the initial position of the dyeing mechanism, and after the slide moves and is dyed, it is received and discharged by the discharge assembly at the terminal position; in this process, the power for the slide to move out of the feed assembly and into the discharge assembly comes from the power of the dyeing mechanism to move the slide.

[0035] According to the arrangement of the way in which the staining mechanism moves the glass slide during the staining process, it is preferred that the feeding assembly flips the glass slide 180° through the glass slide flipping mechanism 1. Specifically, the glass slide flipping mechanism 1 includes a glass slide flipping clamp 11 and a glass slide flipping power source 12. The glass slide flipping clamp 11 is provided with at least one set of glass slide clamping claws 111 for clamping the glass slide, and the glass slide flipping clamp 11 is connected to the power output shaft of the glass slide flipping power source 12 and rotates therewith, thereby realizing the flipping of the glass slide.

[0036] Similarly, the discharging assembly turns the dye sheet 180° through the dye sheet turning mechanism 2. Specifically, the dye sheet turning mechanism 2 includes a dye sheet turning clamp 21 and a dye sheet turning power source 22; the dye sheet turning clamp 21 is provided with at least one set of dye sheet clamping claws 211 for clamping the dye sheet to be turned over after dyeing; the dye sheet turning clamp 21 is connected to the power output shaft of the dye sheet turning power source 22 and rotates therewith to realize the turning of the dye sheet.

[0037] The glass slide flipping clamp 11 and the dye slide flipping clamp 21 are connected to the power output shaft of the corresponding power source. The glass slide flipping mechanism 1 and the dye slide flipping mechanism 2 can be provided with support plates, bearings and other methods known in the art to fix the axial direction of the power output shaft of the power source, and then the glass slide flipping clamp 11 or the dye slide flipping clamp 21 is sleeved on the output shaft. When the power source works, the output shaft is driven to rotate, and the glass slide flipping clamp 11 or the dye slide flipping clamp 21 will also rotate accordingly.

[0038] When the glass slide clamping jaws 111 and the dye slide clamping jaws 211 are provided as a group, the glass slide / stain slide can be clamped by controlling the width and gap of the clamping jaws. More preferably, the glass slide clamping jaws 111 and the dye slide clamping jaws 211 are provided in two or more groups, respectively, and are located on both sides of the glass slide loading sample area to clamp the glass slide.

[0039] Preferably, the height of the slide clamping jaw 111 when the slide flipping mechanism 1 is facing away from the staining mechanism is lower than the height of the slide clamping jaw 111 when the slide flipping mechanism 1 is rotated to face the staining mechanism; The height of the dye sheet clamping claw 211 when the dye sheet turning mechanism 2 faces the dyeing mechanism is lower than the height of the dye sheet clamping claw 211 when the dye sheet turning mechanism 2 rotates to face away from the dyeing mechanism.

[0040] Preferably, the glass slide clamp 111 is at different levels when the glass slide flipping mechanism 1 is facing away from the dyeing mechanism to receive the glass slide and when it is turned toward the dyeing mechanism. Specifically, the height of the glass slide clamp 111 is lower when the flipping mechanism 1 is facing away from the dyeing mechanism, and the height of the glass slide clamp 111 is higher when the flipping mechanism 1 is facing the dyeing mechanism. The dyeing slide clamp 211 is also configured in the same way, so that the height of the dyeing slide clamp 211 is lower when the dyeing slide flipping mechanism 2 is facing the dyeing mechanism, and the height of the dyeing slide clamp 211 is higher when the dyeing slide flipping mechanism 2 is facing away from the dyeing mechanism. Then, the glass slide crosses one step when flipping the feed to the dyeing mechanism, and crosses the second step when flipping from the dyeing mechanism to the discharge assembly, and rises twice in this process; such a configuration can facilitate the layout of the flipping mechanical structure and the dyeing mechanism in the entire device, and at the same time, the glass slide flipping mechanism does not need to protrude from the horizontal plane of the dyeing mechanism.

[0041] The difference in height between the glass slide clamp 111 and the dyeing slide clamp 211 can be achieved by controlling the starting and ending points of the glass slide flipping power source 12 and the dyeing slide flipping power source 22. It can also be achieved by setting a limiter on the glass slide flipping mechanism 1 and the dyeing slide flipping mechanism 2. Preferably, the glass slide flipping mechanism 1 and the dyeing slide flipping mechanism 2 are provided with a limiter, and the limiter is used to limit the rotation range of the glass slide flipping clamp 11 and the dyeing slide flipping clamp 21. The structure is simple, reliable and stable, and the precision requirement is low. The limiter includes restrictions on the rotation range in both clockwise and counterclockwise directions. Specifically, among the limiters provided in the glass slide flipping mechanism 1, the limiter close to one end of the feeding assembly is lower than the limiter close to one end of the dyeing mechanism. Then, when the glass slide flipping clamp 11 rotates to abut the limiter close to one end of the feeding assembly, the height of the glass slide flipping clamp 11 is lower than the height when it rotates to abut the limiter close to one end of the dyeing mechanism. Similarly, by controlling the position of the limiter, when the dye sheet turning mechanism 21 rotates to abut the limiter near one end of the dyeing tank, the height of the dye sheet turning mechanism 21 is lower than the height when it rotates to abut the limiter near one end of the discharging assembly.

[0042] When the glass slide flipping clamp 11 or the dye slide flipping clamp 21 cooperates with the limiter to achieve height control, the sections of the glass slide held by the two clamps are kept horizontal, which can be achieved by the structure of the clamps, or by setting the rotation axes of the two clamps at a certain distance from the clamping surface of the glass slide / dye slide. For example, the connecting plate of the clamp is set higher than the height of the clamp, and the connecting plate protruding from the clamp is connected to the output shaft of the power source.

[0043] Preferably, the feeding assembly further comprises a slide box moving mechanism 3 and a slide pushing mechanism 4, wherein the slide box moving mechanism 3 drives the slide box to a target position, and the slide pushing mechanism 4 is used to push out a single slide in the slide box; The discharging assembly further comprises a dye sheet box moving mechanism 5 and a dye sheet pushing mechanism 6. The dye sheet box moving mechanism 5 drives the dye sheet box to a target position, and the dye sheet pushing mechanism 6 is used to push the dye sheet back to a target position in the sheet storage box.

[0044] Preferably, the feeding assembly further includes a slide box moving mechanism 3 and a slide pushing mechanism 4, which realize the movement of the slide box and the pushing out of the slides in the slide box; the discharging assembly further includes a dyeing box moving mechanism 5 and a dyeing pushing mechanism 6, which realize the sequential feeding of the dyeing slides processed by the dyeing mechanism into the dyeing box for storage. The above structure can further improve the automation degree of the device, improve work efficiency and reduce the labor intensity of operators.

[0045] The slide box and staining box are just different names for the convenience of description. In fact, any slide storage box commonly used in the art can be used.

[0046] In the present application, the slide box moving mechanism 3 can fix (embed or clip into) the slide box, and then drive the slide box to move, so that the stacked and stored slides move with the slide box and are pushed in sequence by the slide pushing mechanism 4 to push a single slide. Similarly, the dyed slides can also be pushed in sequence by the dyed slide pushing mechanism 6 to the dyed slide box moving mechanism for storage.

[0047] Preferably, the slide pushing mechanism 4 pushes the slide to the slide guide rail 7, and the slide guide rail 7 has a first groove 71 for the slide clamping claw 111 to fall into; The dye sheet pushing mechanism 6 pushes the dye sheet flipped and placed by the dye sheet flipping mechanism 2 on the dye sheet guide rail 8. The dye sheet guide rail 8 has a second groove 81 for the dye sheet clamping claw 211 to fall into.

[0048] Preferably, the glass slide pushing mechanism 4 pushes the glass slide to the glass slide guide 7, and the glass slide guide 7 has a first groove 71 for the glass slide clamp 111 to fall into; the dye slide pushing mechanism 6 pushes the dye slide flipped and placed in by the dye slide turning mechanism 2 on the dye slide guide 8, and the dye slide guide 8 has a second groove 81 for the dye slide clamp 211 to fall into, which better cooperates with the glass slide turning mechanism 1 and the dye slide turning mechanism 2.

[0049] The slide guide rail 7 can be integrally arranged with the guide rail for moving the slide box by the slide box moving mechanism 3. Similarly, the dyeing slide guide rail 8 can also be integrally arranged with the guide rail for moving the dyeing slide box by the dyeing slide box moving mechanism 5.

[0050] Preferably, the dye box moving mechanism 5 includes a dye box tray 51, a dye box guide rail 52 and a dye box moving power source 53, the dye box tray 51 is slidably connected to the dye box guide rail 52, and the dye box moving power source 53 drives the dye box tray 51 to move.

[0051] In the art, clean, unused slides are usually stored by stacking them and taking them out from the bottom opening of the slide box one by one. However, clean slides can also be stored in a storage box with multiple layers of card blocks inside and pushed out from each layer for use. However, slides with samples attached need to be stored in a certain space (such as the stained slides in this application), so it is better to use a storage box with multiple layers of card blocks inside. Whether it is taken out from the bottom or from each layer, it can be achieved by using a push mechanism to push out along the opening of the box.

[0052] Preferably, the slide box adopts a method of taking out clean slides from the bottom in sequence, while the staining slide box adopts a method of having multiple layers of blocks stacked at intervals. Then the slide box moving component 3 only needs to move the slide box to the set position, and then the slide pushing mechanism 4 moves back and forth to push out the slides from the bottom in sequence.

[0053] The dyeing box needs to be lifted and lowered to receive the dyeing sheets. Therefore, the dyeing box moving mechanism 5 preferably includes a dyeing box tray 51, a dyeing box guide rail 52 and a dyeing box moving power source 53. The dyeing box tray 51 is slidably connected to the dyeing box guide rail 52, and the dyeing box moving power source 53 drives the dyeing box tray 51 to move in the vertical direction, so that the dyeing sheets are sequentially stored in layers of different heights of the dyeing box.

[0054] When a dyeing sheet box is full of dyeing sheets, the dyeing sheet box moving mechanism 5 can drive the full dyeing sheet box to reset, so as to facilitate taking out and replacing.

[0055] The transmission of the driving force of the dyeing box moving power source 53 can be achieved by using a combination of a belt and a driving wheel and a driven wheel, or by using a gear transmission or other structure known in the art.

[0056] Preferably, the dyeing box moving mechanism 5 further includes a dyeing box switching mechanism 54; The dye box tray 51 has at least two installation positions for dye boxes; the dye box switching mechanism 54 is used to push the dye box tray 51 to switch the dye boxes.

[0057] More preferably, the dyeing box moving mechanism 5 also includes a dyeing box switching mechanism 54; the dyeing box tray 51 has at least two installation positions for dyeing boxes, and the dyeing box switching mechanism 54 is used to push the dyeing box tray 51 to move, so as to switch the dyeing box, which can reduce the downtime or waiting time caused by the replacement of the dyeing box. When the glass slides in one dyeing box are used up or the dyeing slides are full, switch to another one to continue working. The previous dyeing box can be replaced by the staff first, or it can be replaced at once when several dyeing boxes on the dyeing box tray 51 need to be replaced.

[0058] The dye box switching mechanism 54 may include a switching base provided with a switching guide rail and a switching power source, and the dye box tray 51 may be slidably arranged on the switching guide rail. Then, the entire dye box switching mechanism 54 moves along the dye box guide rail 52 under the drive of the dye box moving power source 55, and then the dye box switching mechanism 54 itself can switch different installation positions of the dye box tray 51.

[0059] The dyeing box tray 51 has at least two installation positions for dyeing boxes, which means that the dyeing box tray 51 is detachably connected to the dyeing box by means of a snap connection, etc., and has at least two connection positions. The shape and size of the dyeing box tray 51 are determined according to the properties and size of the dyeing box.

[0060] Preferably, the slide pushing mechanism 4 includes a slide pushing rod 41, a slide pushing guide rail 42 and a slide pushing power source 43; the slide pushing rod 41 is slidably connected to the slide pushing guide rail 42, and the slide pushing power source 43 drives the slide pushing rod 41 to move; The dye slide pushing mechanism 6 includes a dye slide push rod 61, a dye slide pushing guide rail 62 and a dye slide pushing power source 63; the dye slide push rod 61 is slidably connected to the dye slide pushing guide rail 62, and the dye slide pushing power source 63 drives the dye slide push rod 61 to move. The glass slide pushing mechanism 4 preferably includes a glass slide push rod 41, a glass slide pushing guide rail 42 and a glass slide pushing power source 43; the glass slide push rod 41 is slidably connected to the glass slide pushing guide rail 42, and the glass slide pushing power source 43 drives the glass slide push rod 41 to move. The axial direction of the glass slide push rod 41 is set to the direction in which the glass slide in the glass slide box can enter and exit. Similarly, the transmission of the driving force of the glass slide pushing power source 43 can be achieved by using a combination of a belt and a driving wheel and a driven wheel, or by using a gear transmission or other structures known in the art.

[0061] Similarly, the dye sheet pushing mechanism 6 preferably includes a dye sheet pushing rod 61, a dye sheet pushing guide rail 62 and a dye sheet pushing power source 63; the dye sheet pushing rod 61 is slidably connected to the dye sheet pushing guide rail 62, and the dye sheet pushing power source 63 drives the dye sheet pushing rod 61 to move. The axis direction of the dye sheet pushing rod 61 is set to the direction in which the dye sheet in the dye sheet box can enter and exit.

[0062] In fact, the glass slide pushing mechanism 4 and the dye slide pushing mechanism 6 are both structures in which the power source drives the push rod to move back and forth through the transmission member, but according to the different pushing requirements of the glass slide and the dye slide and the position in the instrument, the size and bending of the specific structure will be different. For the sake of clarity, the present application names them separately.

[0063] Preferably, the dyeing device comprises a housing, the dyeing mechanism is detachably arranged in the housing, and the feeding assembly and the discharging assembly are located at two ends of the dyeing mechanism; An initial position is set between the staining mechanism and the feeding assembly for the feeding assembly to flip the slide; An end point is set between the dyeing mechanism and the discharging component for the discharging component to turn over the dyed sheet.

[0064] It is preferred that the dyeing device is provided with a shell as a whole to cover the internal mechanical mechanism to avoid accidental touch, dust ingress, etc. affecting the use. And the dyeing mechanism arranged in the shell is detachable and replaceable. At the same time, the feed component is located at one end of the dyeing mechanism, and an initial position is set between the two for flipping the glass slide; the discharge component is located at the other end of the dyeing mechanism, and an end position is set between the two for flipping the dyed slide. The initial position and the end position can be part of the dyeing mechanism, and different types of dyeing mechanisms are designed with initial positions and end positions to achieve coordination. The initial position and the end position can also be a separate structure in the shell, or a part of the structure provided by the feed component and the discharge component.

[0065] Preferably, the staining mechanism is any one of a Gram staining mechanism, a fluorescent staining mechanism or a Regis staining mechanism.

[0066] The preferred dyeing mechanism is any one of a Gram dyeing mechanism, a fluorescent dyeing mechanism or a Wright-Giemsa dyeing mechanism, which is detachably arranged in the housing, and different dyeing mechanisms can be replaced according to the use needs, and a variety of dyeing operations can be achieved using one device, so that it can be applied to a variety of dyeing processes such as Gram dyeing, fluorescent dyeing, Wright-Giemsa dyeing (Wright-Giemsa dyeing) of bacteria and cell smears, and has a wider range of applications. The dyeing mechanism can be threadedly connected to the housing through a connecting plate to achieve detachability; in addition, it can also be detachably connected by conventional methods in the field such as snap-on connection.

[0067] The outer dimensions of different types of dyeing mechanisms can be the same, and the reserved installation positions of the dyeing mechanisms in the housing are the same. The outer dimensions of different types of dyeing mechanisms can also be different. The installation positions provided in the housing meet the installation requirements of the dyeing mechanism of the largest size, and smaller ones can also be installed. A plurality of positioning holes can also be provided in the housing to facilitate the installation of the dyeing mechanism. When the outer dimensions of the dyeing mechanisms are different, the feed assembly and / or the discharge assembly are detachably connected or movable with the housing to adapt to dyeing mechanisms of different sizes and realize the flipping of glass slides or dyeing slides.

[0068] Preferably, when the dyeing mechanism is a Gram dyeing mechanism, the dyeing mechanism includes, from the initial position end to the terminal position end, a primary dyeing position, a washing position 1, a mordanting position, a washing position 2, a bleaching position, a washing position 3, a re-dyeing position, and a washing position 4 in sequence; When the dyeing mechanism is a fluorescent dyeing mechanism, the dyeing mechanism includes a fixing position, a buffer solution washing position, a scraping position, a dyeing liquid position, and a cleaning position from the initial position end to the terminal position end; When the dyeing mechanism is a Regis dyeing mechanism, the dyeing mechanism includes an A liquid dyeing position, a B liquid dyeing position, and a cleaning position in sequence from the initial position end to the terminal position end.

[0069] Dyeing institutions are set up with different processes and corresponding regional functions according to their types. Specifically, when the dyeing institution is a Gram dyeing institution, the dyeing institution needs to set up primary dyeing, mordant dyeing, decolorization, and re-dyeing areas, and separate them with cleaning positions. When the dyeing institution is a fluorescent dyeing institution, it is necessary to set up a fixed position, a buffer rinse position, a scraper position, a dye position, and a cleaning position. When the dyeing institution is a Regis dyeing institution, it is necessary to set up an A liquid dyeing position, a B liquid dyeing position, and a cleaning position.

[0070] Pollen from different regions can be obtained by setting up different work areas in the dyeing mechanism, and supplying corresponding reagents to each work area. A modular dyeing mechanism can also be provided, in which the number of work areas inside is fixed, and then according to the needs of different types of dyeing, several work areas can be combined as one area (for example, all as primary dyeing areas), or one or several work areas can be left idle.

[0071] The primary dyeing, mordant dyeing, and secondary dyeing referred to in the above-mentioned Gram staining, or the buffer solution and dye solution referred to in the fluorescent staining, or the A solution and B solution referred to in the Regis staining are all reagents used for staining operations known in the art, and are not the innovation of this application. This application only integrates them into the device to realize automatic staining operations. Among them, the cleaning solution used may also be different depending on the type of staining.

[0072] Preferably, the dyeing mechanism is further provided with a scraping position and a drying position upstream of the terminal position; or, the dyeing mechanism is provided with a scraping position upstream of the terminal position, and a drying mechanism is arranged at the terminal position.

[0073] Preferably, the dyeing mechanism is further provided with a scraping position and a drying position upstream of the terminal position, or the dyeing mechanism is provided with a scraping position upstream of the terminal position, and a drying mechanism is provided at the terminal position. That is, the drying position can be provided separately before the terminal position, or can be provided at the terminal position, by controlling the timing of the dye sheet being dried first and then turned over by the dye sheet turning mechanism 2.

[0074] The upstream here is determined according to the moving direction of the slide. When the drying position is not set at the end position, the drying position is located between the scraping position and the end position, that is, the stained slide is first scraped and then dried, and the drying efficiency is higher.

[0075] In order to facilitate the design of the overall device, as well as the modular design and production of the dyeing mechanism, it is preferred that the dyeing mechanism adopts the same external dimensions, the same number and size of internal work areas, and one or more work areas are combined for use or left idle as blank positions according to the needs of different types of dyeing mechanisms. For example, 10 work areas can be set between the initial position and the terminal position, a water scraping position is set, and a drying mechanism is set at the terminal position, and the initial position, the terminal position, the water scraping position and the work area are all set in the dyeing mechanism (then the dyeing mechanism is divided into 13 areas in total), and the purpose of each area is designed according to whether it is used for Gram staining, fluorescent staining or Regis staining.

[0076] Specifically, when the dyeing mechanism is a Gram dyeing mechanism, the sequence is initial position, primary dyeing position 1, primary dyeing position 2, washing position 1, mordanting position 1, mordanting position 2, washing position 2, decolorization position, washing position 3, re-dyeing position, washing position 4, scraping position, and end point position. Fig.10 shown.

[0077] When the staining mechanism is a fluorescent staining mechanism, the sequence is initial position, fixed position, buffer solution flushing position, scraping position, dye position 1, dye position 2, dye position 3, dye position 4, dye position 5, cleaning position 1, cleaning position 2, scraping position, and end point position. Fig.11 shown.

[0078] When the dyeing mechanism is a Ruiji dyeing mechanism, the sequence is initial position, A liquid dyeing position 1, A liquid dyeing position 2, B liquid dyeing position 1, blank position 1, blank position 2, B liquid dyeing position 2, blank position 3, blank position 4, cleaning position 1, cleaning position 2, scraping position, and end position. Fig.12 shown.

[0079] Among them, when the dyeing mechanism is a Regis dyeing mechanism, A liquid dyeing position one and A liquid dyeing position two are two working areas used as A liquid dyeing positions; then the multiple working areas including B liquid dyeing position one, blank position one, blank position two, B liquid dyeing position two, blank position three and blank position four are used as positions for B liquid supply and A liquid and B liquid mixing.

[0080] The dyeing mechanism used in this application can use the existing linear dyeing structure on the market, or can use the following structure: The dyeing mechanism includes: a dyeing tank assembly, a carrier supporting structure a3, and a carrier driving mechanism a4. The dyeing tank assembly includes a base a1 and a dyeing platform a2 arranged in the base a1. The dyeing platform a2 is provided with at least one reagent output groove a21 and at least one liquid guide groove a22. The reagent output groove a21 is provided with a reagent output hole a211; the reagent output groove a21 and the liquid guide groove a22 extend on the surface of the dyeing platform a2, and the extension direction forms an angle with the moving direction of the carrier, and at least one end of the reagent output groove a21 and the liquid guide groove a22 extends to the edge of the dyeing platform a2; the carrier supporting structure a3 is used to form a gap between the carrier and the surface of the dyeing platform a2, and the carrier driving mechanism a4 drives the carrier and the dyeing platform a2 to maintain the gap movement. In the above-mentioned staining mechanism, the reagent output groove a21 outputs the staining liquid to contact the sample on the carrier; and the liquid guide groove a22 changes the flow direction of the reagent during the movement of the carrier, so that the contact between the reagent and the sample is more complete, avoiding the situation where some areas of the carrier sample are not in contact with the staining liquid, resulting in uneven staining, thereby improving the staining quality, achieving sufficient staining in a shorter path or time, and having higher staining efficiency.

[0081] Specifically, the staining platform a2 is placed in the base a1, and the reagent output hole a211 of the reagent output groove a21 sprays out the staining liquid. The liquid level of the staining liquid protruding from the surface of the staining platform a2 is greater than the gap between the carrier and the staining platform a2. Due to the wetting effect of the liquid, the staining liquid is transferred to the carrier for staining, and at the same time, a part of the staining liquid adheres to the carrier, and the excess staining liquid in the reagent output groove a21 will flow into the base a1 for recovery. However, in this process, the position of the dyeing liquid on the carrier is random, and the dyeing effect is difficult to guarantee. Therefore, the reagent output groove a21 and the liquid guide groove a22 are set to extend on the surface of the dyeing platform a2, and the extension direction is at an angle with the moving direction of the carrier. In the process of carrier movement, whether it is when the reagent output groove a21 contacts the dyeing liquid or when passing through the liquid guide groove a22, the dyeing liquid is either blocked by the liquid guide groove and flows to the area of ​​the carrier without the dyeing groove blocking, or the dyeing liquid flows into the liquid guide groove, and the dyeing liquid is guided to the area corresponding to the carrier along the extension direction of the liquid guide groove, so that the extension of the carrier surface and the moving direction of the carrier at a certain angle (the above two effects are collectively referred to as guiding effects in this application) is more conducive to the full contact of the dyeing liquid with each area of ​​the carrier sample. In order to facilitate the movement and dyeing of the carrier, the length direction of the dyeing platform a2 is usually the moving direction of the carrier, and the width direction of the dyeing platform a2 is perpendicular to the moving direction of the carrier. When set in this way, when the reagent output groove a21 and the liquid guide groove a22 are at an angle of 90° with the moving direction of the carrier, the two grooves extend along the width direction of the dyeing platform a2.

[0082] The carrier forms a gap with the surface of the dyeing platform a2 by the carrier support structure a3. The carrier support structure a3 can be arranged on the base a1 or the dyeing platform a2, for example, a structure known in the art such as a horizontally arranged support protrusion can be used. The carrier driving mechanism a4 is used to achieve the gap movement between the carrier and the dyeing platform a2.

[0083] Preferably, the dyeing platform a2 is provided with a plurality of liquid guiding grooves a22 to guide the extension of the dyeing liquid on the carrier surface for multiple times. When a plurality of liquid guiding grooves a22 are provided, adjacent liquid guiding grooves a22 can be parallel to each other or at an angle to each other.

[0084] The liquid guiding groove a22 can have two ends extending to the two edges of the dyeing platform a2 respectively, or only one end extending to one edge of the dyeing platform a2. Among the liquid guiding grooves a22 with only one end extending to the edge of the dyeing platform a2, at least two adjacent liquid guiding grooves a22 extend to the opposite edges of the dyeing platform a2. Then, when the carrier moves, the dyeing liquid will be guided in at least two different directions, and the dyeing will be more uniform. The other liquid guiding grooves a22 can have only one end extending to the edge, or both ends extending to the edge.

[0085] For example, four liquid guiding grooves a22 are provided, the first and second liquid guiding grooves a22 extend in opposite directions, and the third and fourth liquid guiding grooves a22 may have one end extending to one end of the dyeing platform a2, or both ends extending to the two edges respectively.

[0086] More preferably, all the liquid guiding grooves a22 extend to one end of the dyeing platform a2 at only one end, and every two adjacent liquid guiding grooves a22 extend to opposite edges of the dyeing platform a2 respectively, so that the guiding direction of the dyeing liquid is continuously switched during the movement of the carrier, and the dyeing effect is better.

[0087] Preferably, the other end of the liquid guiding groove a22 is located in the middle of the staining platform a2. When only one end of the liquid guiding groove a22 extends to the edge of the staining platform a2, one way is to locate the other end of the liquid guiding groove a22 in the middle of the staining platform a2. In a carrier commonly used in the art, the sample area is located in the middle of the carrier, and the staining liquid is guided from the middle to the periphery to evenly infiltrate the sample. The middle here does not refer to the midpoint in a strict sense, but rather to a certain area near the midpoint.

[0088] In another way, the sum of the lengths of the two liquid guide grooves a22 extending to opposite edges can be set to be greater than or equal to the side length of the dyeing platform a2 perpendicular to the moving direction of the carrier. Then, when the carrier passes through the two liquid guide grooves a22, the guiding paths of the dye liquid partially overlap, and the dye liquid is more fully guided.

[0089] Preferably, the dyeing platform a2 is provided with a plurality of reagent output slots a21, and the two ends of at least one of the reagent output slots a21 extend to the two edges of the dyeing platform respectively, so that the dyeing liquid is directed to two directions when the reagent is output. More preferably, the reagent output slot a21 located at the most upstream of the dyeing platform a2 and the first contact of the carrier has two ends extending to the two edges of the dyeing platform respectively. Other reagent output slots are flexibly arranged as needed.

[0090] Preferably, from upstream to downstream, at least one of the second to last reagent output slots 21 is used to supplement the dye solution. According to the different needs of the detection project, the dyeing of the sample on the carrier can be carried out by different methods such as Gram staining, fluorescent staining, and Reggie staining, which may include primary staining and redyeing. Therefore, preferably, at least one of the multiple reagent output slots 21 is used to supplement the dye solution for redyeing. The supplementary function is to supply the dye solution that has been output and contacted with the sample before. Therefore, according to the movement of the carrier from upstream to downstream, the reagent output slot 21 used for supplementation cannot be the first one, but can be any one or more from the second to the last one. The reagent output slot 21 used to supplement the dye solution can be that both ends extend to the two edges of the dyeing platform respectively, or it can be that only one end extends to the edge of the dyeing platform. Compared with the structure of other reagent output slots, the reagent output slot 21 used to supplement the dye solution does not need to be changed in structure, and only needs to be connected to the output pipe of the target dye solution.

[0091] The reagent output hole a211 is preferably located in the middle of the staining platform a2. Whether the two ends of the reagent output slot a21 extend to the two edges of the staining platform respectively, or only one end of the reagent output slot a21 extends to the edge of the staining platform a2, the reagent output hole a211 is located in the middle of the staining platform a2, so that the position of the reagent output can correspond to the center of the sample area of ​​the carrier.

[0092] Preferably, multiple reagent output grooves a21 and liquid guiding grooves a22 are respectively provided, and the reagent output grooves a21 and the liquid guiding grooves a22 are arranged at intervals along the moving direction of the carrier. The number of reagent output grooves a21 and liquid guiding grooves a22 can be equal or unequal, one liquid guiding groove a22 can be distributed between two reagent output grooves a21, or multiple liquid guiding grooves a22 can be distributed, and similarly, one reagent output groove a21 can be distributed between two liquid guiding grooves a22, or multiple reagent output grooves a21 can be distributed.

[0093] Preferably, the extension direction of the reagent output groove a21 is perpendicular to the moving direction of the carrier, and the liquid guide groove a22 is parallel to the reagent output groove a21. The reagent output groove a21 and the liquid guide groove a22 extend on the surface of the dyeing platform a2, and the extension direction forms an angle with the moving direction of the carrier, which means that the two are not parallel, and the angle can be any angle, greater than 0° and less than 180°. However, setting it to 30-120° (more preferably 45-90°) has a better guiding effect on the dyeing liquid. Preferably, the extension direction of the reagent output groove a21 is perpendicular to the moving direction of the carrier, and the liquid guide groove a22 is parallel to the reagent output groove a21 (that is, also perpendicular to the moving direction of the carrier), and all the grooves are parallel and perpendicular to the extending direction of the carrier.

[0094] The dyeing platform a2 and the base a1 can be integrally formed, or can be separately processed and detachably connected. Preferably, the dyeing platform a2 and the base a1 are detachably connected.

[0095] Preferably, the dyeing tank assembly further includes at least one cleaning component a5 and a drying structure a6, and the cleaning component a5 is arranged between the dyeing platform a2 and the drying structure a6.

[0096] The order of dyeing operation in this field is that the carrier is first dyed with dye solution (which may include multiple dye solutions according to different projects, and may or may not be washed in the middle), washed after dyeing, and then dried. Therefore, it is preferred that the dyeing platform also includes at least one washing component a5 and a drying structure a6, and the washing component a5 is arranged between the dyeing platform a2 and the drying structure a6. Then, the sample on the carrier is dyed, washed and dried in sequence, and a dyeing carrier that meets the detection requirements can be obtained, and the degree of automation and work efficiency are higher.

[0097] In the present application, the number of cleaning components a5 can be one, two or more, and can be flexibly set according to the difficulty and needs of cleaning.

[0098] Preferably, the cleaning component a5 is provided with a liquid outlet a51, and the liquid outlet a51 is arranged to spray the cleaning liquid obliquely relative to the surface of the dyeing platform a2. The cleaning liquid will be sprayed obliquely and fall on the dyed carrier, with a wider contact area and better cleaning effect.

[0099] It is further preferred that the cleaning component a5 includes a base a52 and a cleaning liquid output structure a53 disposed on the base a52. The cleaning liquid output structure a53 has a chamber for the cleaning liquid to flow therein. The output surface of the cleaning liquid output structure a53 is arranged at an angle to the surface of the dyeing platform, and the liquid outlet a51 is arranged on the output surface. The base a52 facilitates the installation of the cleaning component a5. The cleaning liquid output structure a53 allows the cleaning liquid to flow from the internal chamber and is sprayed out at an angle from the liquid outlet a51 arranged on the output surface.

[0100] The inclination here means that the liquid outlet a51 has an angle greater than 0° with both the horizontal plane and the vertical plane. When the output surface is set to be inclined, the liquid outlet a51 can be formed by drilling vertically on the output surface. When other structures are used, the liquid outlet a51 can be obtained by drilling obliquely to the plane. The connection port between the chamber of the cleaning liquid output structure a53 and the outside can be located at any part such as the bottom or side of the base a52, which is convenient for hiding the pipeline. The cleaning liquid can flow and spray out through the power of the pump.

[0101] Preferably, the output surface is provided with a plurality of liquid outlet holes 11, and the cleaning liquid is sprayed at different positions, so as to fully clean the carrier. According to different needs, the liquid outlet holes 11 can be arranged in a single row, or in multiple rows and columns. The number of liquid outlet holes 11 can be 2-20, preferably 2-15, and more preferably 2-10.

[0102] The drying structure a6 can be a separate drying component a61, or a wiper component a62 and a drying component a61 can be provided simultaneously. When provided simultaneously, the wiper component a62 is located upstream of the drying component a61, and the carrier scrapes off part of the water before drying, which increases the drying efficiency.

[0103] Preferably, the wiper component a62 used in the present application includes a plurality of wiper protrusions a621, each of which will contact the surface of the carrier and gently scrape off the surface water when the carrier passes by. During the movement of the carrier, the carrier continuously contacts the plurality of wiper protrusions a621, and the drying effect is better, and the interval arrangement facilitates the timely discharge of the scraped water.

[0104] Preferably, the drying component a61 includes an air guide 311, a fan 312 and a heater; the heater is used to heat the air, while the fan 312 is used to drive the air flow, and the air guide 311 is used to guide the hot air flow to the carrier. The air guide 311 is set to guide the hot air flow to improve the drying efficiency. At the same time, the fan 312 and the heater can be set below or in other positions, which is more flexible. Preferably, the direction of the airflow driven by the fan a612 has an angle with the direction of the airflow guided by the air guide a611, so that the airflow is introduced into the target area after being deflected by the side wall of the air guide a611. The heater can be set before or after the fan 312, and the hot air flow finally enters the air guide 311.

[0105] The present application may also be provided with a waterproof cover, at least covering the top of the cleaning component a5, so as to control the cleaning liquid sprayed from the cleaning component a5 to be within a certain range, so as to prevent the cleaning liquid from splashing onto other parts and affecting the operation of the entire instrument. At the same time, a waterproof cover is provided, and the force of the cleaning liquid spraying can be set to be a little larger, so as to achieve a better cleaning effect on the carrier. The waterproof cover may adopt a cover structure known in the art, and may be provided by means of a snap-on or threaded connection. The material of the waterproof cover may also be a metal or acrylic structure commonly used in the art, preferably a transparent acrylic, so as to facilitate observation of cleaning and dyeing.

[0106] Preferably, the carrier driving mechanism a4 comprises a power source and a driving transmission structure a41, wherein the driving transmission structure a41 may be a screw rod or a transmission belt having at least two struts. The transmission structure continuously operates under the drive of the power source, thereby driving the carrier to continuously move.

[0107] The thread pitch of the screw is preferably equal to or slightly larger than the width of the carrier, so that one carrier is just located between one thread for movement. Similarly, the pitch between the two pillars of the transmission belt is also preferably equal to or slightly larger than the width of the carrier, so that the carrier is stuck between the two pillars for movement.

[0108] Preferably, the dyeing mechanism also includes a bottom plate, and the dyeing tank assembly is installed above the bottom plate. At the same time, the base a1 is provided with a liquid flow channel a11 connected to the dyeing platform a2, and the bottom plate is provided with a through hole a71 connected to the liquid flow channel a11. The through hole a71 serves as an intermediate structure connecting the dyeing platform a2 and the inlet and outlet liquid pipelines. One end of the through hole a71 is connected to the liquid flow channel a11, and a sealing ring a72 is arranged around the through hole a71. The sealing ring a72 is arranged between the bottom plate and the base a1, so that the liquid inlet and outlet process is along the path of the through hole a71-liquid flow channel a11, and will not leak between the base a1 and the bottom plate; the through hole a71 can be connected to the inlet and outlet liquid pipelines by means of threaded connection or other methods known in the art, and it is not easy to leak, which can avoid contaminating the inside of the device.

[0109] Furthermore, during installation, the inlet and outlet liquid pipelines can be pre-installed and fixed to the bottom plate, and then the dyeing platform a2 can be installed on the bottom plate. The installation is convenient and avoids the trouble of connecting the pipelines to the dyeing platform a2 across the bottom plate.

[0110] Preferably, an annular groove a73 is further provided on the outer periphery of the through hole a71 to serve as an installation space for the sealing ring a72, so that the bottom plate and other parts of the base a1 can be closely attached to each other.

[0111] Preferably, at least two sets of positioning structures may be provided between the bottom plate and the base a1. The positioning structures include positioning pins a74 and matching positioning recesses a75. During installation, the two are aligned and spliced, which is more efficient.

[0112] Since the dyeing process relies on liquid tension, whether the dyeing tank assembly is level has a great influence on the sufficient contact between the carrier and the dyeing liquid. Therefore, it is preferred that the bottom plate or the dyeing tank assembly is also provided with a level gauge a8, so as to facilitate timely observation of whether the entire device is in a level state during installation and operation to ensure the dyeing effect.

[0113] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A dyeing device, characterized in that: Including: feeding components, dyeing mechanism, discharging components, The feeding assembly is used to flip a single glass slide 180 degrees and feed it into the staining mechanism; The dyeing mechanism is used to dye the slide to obtain a dyed slide; The discharging assembly is used to turn the dye sheet 180 degrees and discharge the dye sheet.

2. The dyeing device according to claim 1, characterized in that: The feed assembly comprises a glass slide turning mechanism (1), wherein the glass slide turning mechanism (1) comprises a glass slide turning clamp (11) and a glass slide turning power source (12); the glass slide turning clamp (11) is connected to a power output shaft of the glass slide turning power source (12) and rotates therewith, and the glass slide turning clamp (11) is also provided with at least one set of glass slide clamping claws (111); The discharging assembly comprises a dye sheet turning mechanism (2), and the dye sheet turning mechanism (2) comprises a dye sheet turning clamp (21) and a dye sheet turning power source (22); the dye sheet turning clamp (21) is connected to a power output shaft of the dye sheet turning power source (22) and rotates therewith, and the dye sheet turning clamp (21) is also provided with at least one set of dye sheet clamping claws (211).

3. The dyeing device according to claim 2, characterized in that: The height of the glass slide clamp (111) when the glass slide turning mechanism (1) is facing away from the staining mechanism is lower than the height of the glass slide clamp (111) when the glass slide turning mechanism (1) is rotated to face the staining mechanism; The height of the dye sheet clamping claw (211) when the dye sheet turning mechanism (2) faces the dyeing mechanism is lower than the height of the dye sheet clamping claw (211) when the dye sheet turning mechanism (2) rotates to face away from the dyeing mechanism.

4. The dyeing device according to any one of claims 2 to 3, characterized in that: The feed assembly further comprises a slide box moving mechanism (3) and a slide pushing mechanism (4), wherein the slide box moving mechanism (3) drives the slide box to a target position, and the slide pushing mechanism (4) is used to push out a single slide in the slide box; The discharging assembly further comprises a dye sheet box moving mechanism (5) and a dye sheet pushing mechanism (6), wherein the dye sheet box moving mechanism (5) drives the dye sheet box to a target position, and the dye sheet pushing mechanism (6) is used to push the dye sheet back to the target position in the sheet storage box.

5. The dyeing device according to claim 4, characterized in that: The glass slide pushing mechanism (4) pushes the glass slide to the glass slide guide rail (7), and the glass slide guide rail (7) has a first groove (71) for the glass slide clamping claw (111) to fall into; The dye sheet pushing mechanism (6) pushes the dye sheet turned over and placed in by the dye sheet turning mechanism (2) on the dye sheet guide rail (8), and the dye sheet guide rail (8) has a second groove (81) for the dye sheet clamping claw (211) to fall into.

6. The dyeing device according to claim 4, characterized in that: The dyeing box moving mechanism (5) comprises a dyeing box tray (51), a dyeing box guide rail (52) and a dyeing box moving power source (53); the dyeing box tray (51) is slidably connected to the dyeing box guide rail (52), and the dyeing box moving power source (53) drives the dyeing box tray (51) to move.

7. The dyeing device according to claim 6, characterized in that: The dyeing box moving mechanism (5) further comprises a dyeing box switching mechanism (54); The dyeing box tray (51) has at least two installation positions for dyeing boxes; the dyeing box switching mechanism (54) is used to push the dyeing box tray (51) to switch the dyeing boxes.

8. The dyeing device according to claim 4, characterized in that: The slide pushing mechanism (4) comprises a slide pushing rod (41), a slide pushing guide rail (42) and a slide pushing power source (43); the slide pushing rod (41) is slidably connected to the slide pushing guide rail (42), and the slide pushing power source (43) drives the slide pushing rod (41) to move; The dye sheet pushing mechanism (6) comprises a dye sheet pushing rod (61), a dye sheet pushing guide rail (62) and a dye sheet pushing power source (63); the dye sheet pushing rod (61) is slidably connected to the dye sheet pushing guide rail (62), and the dye sheet pushing power source (63) drives the dye sheet pushing rod (61) to move.

9. The dyeing device according to any one of claims 1-3 and 5-8, characterized in that: The dyeing device comprises a shell, a dyeing mechanism is detachably arranged in the shell, and the feeding assembly and the discharging assembly are located at two ends of the dyeing mechanism; An initial position is set between the staining mechanism and the feeding assembly for the feeding assembly to flip the slide; An end point is set between the dyeing mechanism and the discharging component for the discharging component to turn over the dyed sheet.

10. The dyeing device according to claim 9, characterized in that: The staining mechanism is any one of a Gram staining mechanism, a fluorescent staining mechanism or a Regis staining mechanism.

11. The dyeing device according to claim 10, characterized in that: When the dyeing mechanism is a Gram dyeing mechanism, the dyeing mechanism includes, from the initial position end to the terminal position end, a primary dyeing position, a washing position 1, a mordanting position, a washing position 2, a bleaching position, a washing position 3, a re-dyeing position, and a washing position 4 in sequence; When the dyeing mechanism is a fluorescent dyeing mechanism, the dyeing mechanism includes a fixing position, a buffer solution washing position, a scraping position, a dyeing liquid position, and a cleaning position from the initial position end to the terminal position end; When the dyeing mechanism is a Regis dyeing mechanism, the dyeing mechanism includes an A liquid dyeing position, a B liquid dyeing position, and a cleaning position in sequence from the initial position end to the terminal position end.

12. The dyeing device according to claim 11, characterized in that: The dyeing mechanism is also provided with a scraping position and a drying position upstream of the terminal position; or, the dyeing mechanism is provided with a scraping position upstream of the terminal position, and a drying mechanism is provided at the terminal position.

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