Magnetic resonance imaging auxiliary device and method for improving in-vitro specimen slice magnetic resonance imaging quality

Abstract

The invention provides a magnetic resonance imaging auxiliary device and a method for improving in-vitro specimen slice magnetic resonance imaging quality, and belongs to the technical field of specimen slice magnetic resonance imaging. The magnetic resonance imaging auxiliary device comprises a coil adaptation platform which is a semi-cylinder filled with perfluoropolyether ester, and the outer diameter of the coil adaptation platform is matched with the inner diameter of a mouse coil; the object carrying box is arranged on the plane side wall of the semi-cylinder of the coil adaptation platform, and the interior of the object carrying box is filled with perfluoropolyether ester; and the box cover and the plane side wall can be opened and closed. According to the method for improving the magnetic resonance imaging quality of the in-vitro specimen slice, a magnetic resonance imaging auxiliary device is used. According to the device and the method, the specimen slice is flatly placed in an effective detection range of a magnetic field center of a mouse coil, magnetic sensitive artifacts generated at the junction of air and the specimen slice are eliminated, and the detection efficiency and the image quality of magnetic resonance imaging of the experimental in-vitro specimen slice are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of magnetic resonance imaging of specimen slices, and in particular relates to a magnetic resonance imaging auxiliary device and a method for improving the quality of magnetic resonance imaging of in vitro specimen slices. Background Art

[0002] In the in vitro specimen experiment of MRI scanning of human lesions, the size of the human excised specimen is obviously smaller than the inner diameter of the large in vivo scanning coil suitable for the human body, and larger than Figure 3 The inner diameter of the MRI mouse coil 200 shown in FIG. Therefore, it is often necessary to slice the excised specimen again to make its size conform to the inner diameter of the MRI mouse coil 200 to obtain the specimen slice, and then the MRI mouse coil 200 can be used to perform magnetic resonance imaging on the specimen slice, and achieve refined imaging through magnetic resonance imaging. Moreover, the slice is cut according to the pathology department standard, and the scanned magnetic resonance image can be accurately registered with the pathology image.

[0003] However, in the process of performing magnetic resonance scanning imaging on specimen slices using the MRI mouse coil 200, there are three points that affect the image quality of the magnetic resonance scanning:

[0004] 1. The specimen slices are thin, and the surrounding air surface area is large, which makes the difference between the air and tissue interface obvious, causing magnetic sensitivity artifacts during magnetic resonance imaging.

[0005] 2. The specimen slices are relatively thin, and there is currently a lack of a good carrier support system, so the slices cannot be located in the center of the coil, resulting in uneven magnetic field signals, which affects the imaging quality locally.

[0006] 3. Currently, centrifuge tubes filled with perfluoropolyether are often used for loading. However, they are unstable when floating in oil solutions and are prone to motion artifacts when the magnetic resonance vibrates, affecting image quality. If fixed materials are used in centrifuge tubes, the slices cannot be flattened, the images cannot be located on the same scanning section, and the subsequent section cannot be registered with the pathological slice image.

[0007] Therefore, how to provide a loading device suitable for magnetic resonance scanning of specimen slices, which is used to adapt to the experimental mouse coil to improve the magnetic resonance imaging quality of in vitro specimen slices is a technical problem that technical personnel in this field urgently need to solve. Summary of the invention

[0008] The present invention is made to solve the above problems, and aims to provide a magnetic resonance imaging auxiliary device and a method for improving the quality of magnetic resonance imaging of in vitro specimen slices.

[0009] The invention provides a magnetic resonance imaging auxiliary device, which has the following characteristics: it is used to be arranged in a mouse coil and carry specimen slices of different sizes for magnetic resonance imaging, and comprises: a coil adaptation platform, which is a semi-cylinder filled with perfluoropolyether grease, and the outer diameter of the coil adaptation platform matches the inner diameter of the mouse coil; a carrier box, which is arranged on the plane side wall of the semi-cylinder of the coil adaptation platform, the interior of the carrier box is filled with perfluoropolyether grease, and the interior of the carrier box is also provided with a clamping piece, which is a plurality of pairs of U-shaped protrusions placed flat and facing each other, each pair of U-shaped protrusions has a different size, so as to adapt and clamp corresponding specimen slices of different sizes; and a box cover, which is designed to be openable and closable with the plane side wall, and when the box cover and the plane side wall are closed, the air above the perfluoropolyether grease in the carrier box is compacted and discharged.

[0010] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following feature: wherein the semi-cylinder has a diameter of 2.5 cm and a height of 6 cm.

[0011] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following feature: wherein the object carrying box is integrally formed and recessed on the plane side wall.

[0012] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following feature: wherein the size of the object carrying box is 0.4 cm×2.3 cm×6 cm.

[0013] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following features: wherein the planar shape and size of the box cover match the planar side wall, one side of the box cover in the length direction is hinged to one side of the planar side wall in the length direction, and the other side is lock-connected.

[0014] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following features: the box cover has a female lock buckle on one side which is locked with the plane side wall, the coil adapter platform has a male lock buckle on this side, and the female lock buckle matches the male lock buckle in a lock-locked connection.

[0015] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following features: a plurality of raised piles are distributed on a side of the box cover close to the coil adaptation platform, and the positions of the raised piles correspond to the areas where the specimen slices fixed by the snap-fit ​​parts are located. When the box cover and the plane side wall are closed, the raised piles abut against the specimen slices fixed by the snap-fit ​​parts and press them against the inner bottom of the carrier box.

[0016] The magnetic resonance imaging auxiliary device provided by the present invention may also have the following feature: wherein the protruding height of the protruding pile is not greater than the depth of the object carrying box.

[0017] The present invention also provides a method for improving the quality of magnetic resonance imaging of in vitro specimen slices, which has the following characteristics: using any of the aforementioned magnetic resonance imaging auxiliary devices, the method comprises the following steps: S10, placing the in vitro specimen slices flat in a carrier box, and clamping them with one of the pairs of U-shaped protrusions adapted to their size; S20, filling the carrier box with perfluoropolyether grease; S30, closing the box cover and the planar side wall of the coil adaptation platform, and the closing surface fits the carrier box so that the specimen slices and / or the air above the perfluoropolyether grease in the carrier box are compacted and discharged; S40, setting the magnetic resonance imaging auxiliary device in the magnetic resonance mouse coil to perform magnetic resonance imaging of the specimen slices.

[0018] The method for improving the quality of magnetic resonance imaging of in vitro specimen slices provided by the present invention may also have the following feature: wherein, in step S40, when performing magnetic resonance imaging, the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil.

[0019] Functions and Effects of the Invention

[0020] According to the present invention, a magnetic resonance imaging auxiliary device and a method for improving the magnetic resonance imaging quality of in vitro specimen slices are provided. The magnetic resonance imaging auxiliary device comprises: a coil adaptation platform, which is a semi-cylinder filled with perfluoropolyether grease, and the outer diameter of the coil adaptation platform matches the inner diameter of the mouse coil; a carrier box, which is arranged on the plane side wall of the semi-cylinder of the coil adaptation platform, the interior of the carrier box is filled with perfluoropolyether grease, and the interior of the carrier box also has a clamping piece, which is a plurality of pairs of flat and facing U-shaped protrusions, each pair of U-shaped protrusions has a different size, so as to adapt and clamp specimen slices of different sizes; and a box cover, which is designed to be openable and closable with the plane side wall, and when the box cover and the plane side wall are closed, the air above the perfluoropolyether grease in the carrier box is compacted and discharged.

[0021] Therefore, the magnetic resonance imaging auxiliary device of the present invention has the following beneficial effects compared with the prior art:

[0022] (1) The outer diameter of the semi-cylindrical coil adapter platform matches the inner diameter of the mouse coil and the specimen slices are placed flat in the carrier box so that the specimen slices are located within the effective detection range of the magnetic field center of the mouse coil during magnetic resonance imaging, ensuring the uniformity of the local magnetic field and thus improving the efficiency of magnetic resonance imaging.

[0023] (2) The coil adapter platform and the specimen box are filled with perfluoropolyether grease, which can eliminate the contact interface between air and specimen slices, thereby eliminating the magnetic sensitivity artifacts generated by the interface between air and specimen slices; the magnetic resonance imaging signal of perfluoropolyether grease is a uniform and extremely low signal, which forms a natural signal contrast with the specimen slices, and can improve the magnetic resonance image quality of the specimen slices.

[0024] (3) When the box cover is closed, the air above the perfluoropolyether ester in the loading box is compacted and discharged, thereby improving the flatness of the specimen slices and eliminating the magnetic sensitivity artifacts generated by the interface between the air and the specimen slices, further improving the detection efficiency and image quality of the magnetic resonance imaging of the experimental in vitro specimen slices.

[0025] (4) The clamping parts are a plurality of pairs of U-shaped protrusions, so that the magnetic resonance imaging auxiliary device can be adapted to fix specimen slices of various sizes for magnetic resonance imaging alone or simultaneously. The specimen slices can be fixed to ensure the elimination of motion artifacts during the magnetic resonance examination, and multiple specimen slices can be scanned to improve the experimental efficiency.

[0026] Because the method for improving the quality of magnetic resonance imaging of in vitro specimen slices uses the magnetic resonance imaging auxiliary device, the method for improving the quality of magnetic resonance imaging of in vitro specimen slices of the present invention can stably and evenly fix the specimen slices, and can effectively eliminate the magnetic sensitivity artifacts generated by the interface between air and specimen slices, thereby improving the detection efficiency and image quality of magnetic resonance imaging of experimental in vitro specimen slices. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 is a schematic structural diagram of a magnetic resonance imaging auxiliary device according to an embodiment of the present invention;

[0028] Figure 2 is a flowchart of a method for improving the quality of magnetic resonance imaging of ex vivo specimen slices according to an embodiment of the present invention;

[0029] Figure 3 It is a schematic diagram of the structure of an MRI mouse coil in the prior art. DETAILED DESCRIPTION

[0030] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the following embodiments and drawings specifically describe a magnetic resonance imaging auxiliary device and a method for improving the quality of magnetic resonance imaging of in vitro specimen slices of the present invention.

[0031] <Example>

[0032] Figure 1 Schematic diagram of the structure of a magnetic resonance imaging auxiliary device according to an embodiment of the present invention.

[0033] like Figure 1 As shown, this embodiment provides a magnetic resonance imaging auxiliary device 100, which is used to be set in a mouse coil and carry specimen slices of different sizes for magnetic resonance imaging. The magnetic resonance imaging auxiliary device 100 includes a coil adaptation platform 10, a loading box 20 and a box cover 30.

[0034] The coil adaptation platform 10 is a semi-cylinder filled with perfluoropolyether grease, and its outer diameter matches the inner diameter of the mouse coil; the semi-cylinder of the coil adaptation platform 10 has a diameter of 2.5 cm and a height of 6 cm.

[0035] A male locking buckle 10a is provided at one end of the plane side wall of the semi-cylindrical body of the coil adapting platform 10 in the length direction.

[0036] The object carrying box 20 is integrally formed and recessed on the plane side wall of the semi-cylindrical body of the coil adapting platform 10 , and its size is 0.4 cm×2.3 cm×6 cm.

[0037] The interior of the carrier box 20 is filled with perfluoropolyether grease.

[0038] There are several pairs of snap-fitting parts 20a inside the carrier box 20. The snap-fitting parts 20a are pairs of flat and facing U-shaped protrusions. The openings of the pair of U-shaped protrusions face each other and are axially symmetrical with each other about the central axis of the length direction of the carrier box 20. The pair of U-shaped protrusions are used to cooperate with each other to snap-fit ​​specimen slices.

[0039] Specifically, in this embodiment, the clamping member 20a is two pairs of U-shaped protrusions of different sizes (one large and one small).

[0040] As a preference, in this embodiment, the side edges of a pair of larger U-shaped protrusions in the clamping member 20a are provided with recessed notches during the preparation and molding process, thereby saving material consumption while ensuring its structural strength.

[0041] The box cover 30 is in the shape of a plate, and its planar shape and size match the planar side wall of the semi-cylindrical body of the coil adaptation platform 10 .

[0042] One end of the box cover 30 in the length direction is hinged to an end of the plane side wall of the coil adapting platform 10 away from the male locking buckle 10a.

[0043] The other end of the box cover 30 in the length direction is provided with a female lock buckle 30a which is matched with the male lock buckle 10a and is locked in a locking manner.

[0044] The box cover 30 has a plurality of protruding piles 30b on one side close to the coil adapting platform 10.

[0045] The position of the protruding pile 30b corresponds to the area where the specimen slice fixed by the clamping member 20a is located, and the protruding height of the protruding pile 30b is not greater than 0.4 cm.

[0046] When the box cover 30 and the planar side wall of the semi-cylindrical body of the coil adapting platform 10 are closed, the protruding pile 30 b abuts against the specimen slice fixed by the clamping member 20 a and presses it against the inner bottom of the object carrier box 20 .

[0047] As a preferred embodiment, Figure 1As shown, in this embodiment, the number of the raised piles 30b is 6:

[0048] (1) The four protruding piles 30b correspond to the larger clamping piece 20a. When the box cover 30 is closed with the planar side wall of the semi-cylindrical body of the coil adapting platform 10, the four protruding piles 30b are located at the four corners inside the groove formed by a pair of larger U-shaped protrusions in the clamping piece 20a.

[0049] When the size of the specimen slice is completely matched with the size of the clamping piece 20a that fixes it, the four protruding piles 30b can further press the specimen slice to prevent it from drifting in a direction perpendicular to its plane; when the size of the specimen slice is slightly smaller than the size of the clamping piece 20a that fixes it, since the four protruding piles 30b are located at the four corners inside the groove formed by a pair of larger U-shaped protrusions in the clamping piece 20a, the drifting activity space of the specimen slice can be further reduced and the degree of drift can be reduced; in extreme cases, when the size of the specimen slice is much smaller than the size of the clamping piece 20a, any one of the four protruding piles 30b can be used to press the specimen slice against the inner bottom of the carrier box 20 to reduce the degree of drift.

[0050] (2) The other two protruding piles 30b correspond to the smaller clamping piece 20a. When the box cover 30 and the planar side wall of the semi-cylindrical body of the coil adapter platform 10 are closed, the two protruding piles 30b are located inside the groove formed by a pair of smaller U-shaped protrusions in the clamping piece 20a, and abut against the specimen slice fixed by the smaller clamping piece 20a, thereby pressing it to the inner bottom of the carrier box 20.

[0051] Since the inner space of the groove formed by the pair of smaller U-shaped protrusions in the clamping member 20a is small, the corresponding small-sized specimen slices are easy to fix, so the two protruding piles 30b can ensure that they are pressed and fixed to the inner bottom of the object box 20.

[0052] Figure 2 It is a flowchart of a method for improving the quality of magnetic resonance imaging of in vitro specimen slices according to an embodiment of the present invention.

[0053] like Figure 2 As shown, this embodiment also provides a method for improving the quality of magnetic resonance imaging of in vitro specimen slices, which uses the magnetic resonance imaging auxiliary device 100 in this embodiment and includes the following steps:

[0054] S10, placing the ex vivo specimen slice flat in the object carrier box 20, and clamping it by a pair of U-shaped protrusions of the clamping member 20a that are adapted to the size of the specimen slice.

[0055] S20, filling the carrier box 20 with perfluoropolyether grease (perfluoropolyether grease is an oily liquid at room temperature).

[0056] S30 , closing the box cover 30 and the plane side wall of the coil adaptation platform 10 , and the closed surface is attached to the carrier box 20 so as to compact and discharge the air above the perfluoropolyether grease in the carrier box 20 .

[0057] When closed, the plurality of protruding piles 30 b cooperate to further flatten the specimen slice fixed by the clamping member 20 a into the object carrier box 20 .

[0058] S40, the magnetic resonance imaging auxiliary device 100 is arranged in the magnetic resonance mouse coil, and the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil, and magnetic resonance imaging of the specimen slice is performed.

[0059] Functions and Effects of the Embodiments

[0060] According to the present embodiment, a magnetic resonance imaging auxiliary device is provided, which is used to be set in a mouse coil and carry specimen slices of different sizes, because it includes: a coil adaptation platform, which is a semi-cylinder filled with perfluoropolyether grease, and the outer diameter of the coil adaptation platform matches the inner diameter of the mouse coil; a carrier box, which is arranged on the plane side wall of the semi-cylinder of the coil adaptation platform, and the interior of the carrier box is filled with perfluoropolyether grease. The interior of the carrier box also has a clamping piece, which is a plurality of pairs of flat and facing U-shaped protrusions, and each pair of U-shaped protrusions has a different size, so as to adapt and clamp corresponding specimen slices of different sizes; and a box cover, which is designed to be openable and closable with the plane side wall. When the box cover and the plane side wall are closed, the air above the perfluoropolyether grease in the carrier box is compacted and discharged.

[0061] Therefore, compared with the prior art, the magnetic resonance imaging auxiliary device of this embodiment has the following advantages:

[0062] Beneficial effects:

[0063] (1) The outer diameter of the semi-cylindrical coil adapter platform matches the inner diameter of the mouse coil and the specimen slices are placed flat in the carrier box so that the specimen slices are located within the effective detection range of the magnetic field center of the mouse coil during magnetic resonance imaging, ensuring the uniformity of the local magnetic field and thus improving the efficiency of magnetic resonance imaging.

[0064] (2) The coil adapter platform and the specimen box are filled with perfluoropolyether grease, which can eliminate the contact interface between air and specimen slices, thereby eliminating the magnetic sensitivity artifacts generated by the interface between air and specimen slices; the magnetic resonance imaging signal of perfluoropolyether grease is a uniform and extremely low signal, which forms a natural signal contrast with the specimen slices, and can improve the magnetic resonance image quality of the specimen slices.

[0065] (3) When the box cover is closed, the air above the perfluoropolyether ester in the loading box is compacted and discharged, thereby improving the flatness of the specimen slices and eliminating the magnetic sensitivity artifacts generated by the interface between the air and the specimen slices, further improving the detection efficiency and image quality of the magnetic resonance imaging of the experimental in vitro specimen slices.

[0066] (4) The clamping parts are a plurality of pairs of U-shaped protrusions, so that the magnetic resonance imaging auxiliary device can be adapted to fix specimen slices of various sizes for magnetic resonance imaging alone or simultaneously. The specimen slices can be fixed to ensure the elimination of motion artifacts during the magnetic resonance examination, and multiple specimen slices can be scanned to improve the experimental efficiency.

[0067] Furthermore, the object carrying box is integrally formed and recessed on the plane side wall. Such an arrangement can further improve the integration of the magnetic resonance imaging auxiliary device and reduce the air gaps between unnecessary parts that affect the detection efficiency and image quality of magnetic resonance imaging.

[0068] Furthermore, the planar shape and size of the box cover match the planar side wall, one side of the box cover in the length direction is hinged to one side of the planar side wall in the length direction, and the other side is locked. The box cover has a female lock buckle on the side that is locked with the planar side wall, and the coil adapter platform has a male lock buckle on this side, and the female lock buckle matches the male lock buckle and is locked. This arrangement allows the object box and the box cover to be opened and closed quickly and conveniently, which is convenient for experimental operation.

[0069] Furthermore, a plurality of raised piles are distributed on a side of the box cover close to the coil adapter platform, and the position of the raised piles corresponds to the area where the specimen slice fixed by the clamp is located. When the box cover and the plane side wall are closed, the raised piles abut against the specimen slice fixed by the clamp and press it to the inner bottom of the object carrier box. The raised height of the raised piles is not greater than the depth of the object carrier box. With such a configuration, the specimen slice can be further compressed to prevent it from drifting or curling, and the flatness of the specimen slice during magnetic resonance imaging can be improved, thereby further improving the detection efficiency and image quality of magnetic resonance imaging of the specimen slice.

[0070] According to a method for improving the quality of magnetic resonance imaging of in vitro specimen slices provided in this embodiment, any of the aforementioned magnetic resonance imaging auxiliary devices is used, because the method includes the following steps: S10, placing the in vitro specimen slices flat in a carrier box and clamping them with one of the pairs of U-shaped protrusions that are adapted to their size; S20, filling the carrier box with perfluoropolyether grease; S30, closing the box cover and the planar side wall of the coil adaptation platform, and the closing surface fits the carrier box to compact and discharge the specimen slices and / or the air above the perfluoropolyether grease in the carrier box; S40, setting the magnetic resonance imaging auxiliary device in a magnetic resonance mouse coil to perform magnetic resonance imaging of the specimen slices, and when performing magnetic resonance imaging, the specimen slices are located within the effective detection range of the magnetic field center of the mouse coil.

[0071] Therefore, the method for improving the quality of magnetic resonance imaging of in vitro specimen slices in this embodiment uses the magnetic resonance imaging auxiliary device to stably and flatly fix the specimen slices, effectively eliminating the magnetic sensitivity artifacts generated by the interface between air and specimen slices, and can improve the detection efficiency and image quality of magnetic resonance imaging of experimental in vitro specimen slices.

[0072] Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A magnetic resonance imaging auxiliary device, characterized in that: Used to set up in the mouse coil and hold specimen slices of different sizes for MRI, including: The coil adaptation platform is a semi-cylinder filled with perfluoropolyether grease, and the outer diameter of the coil adaptation platform matches the inner diameter of the mouse coil; A carrier box is arranged on the plane side wall of the semi-cylindrical body of the coil adaptation platform, the interior of the carrier box is filled with perfluoropolyether grease, and the interior of the carrier box also has a clamping piece, the clamping piece is a plurality of pairs of U-shaped protrusions placed flat and facing each other, each pair of the U-shaped protrusions has a different size, so as to adapt and clamp the specimen slices of corresponding different sizes; and The box cover and the plane side wall are designed to be openable and closable. When the box cover and the plane side wall are closed, the air above the perfluoropolyether grease in the cargo box is compacted and discharged.

2. The magnetic resonance imaging auxiliary device according to claim 1, characterized in that: in, The semi-cylinder has a diameter of 2.5 cm and a height of 6 cm.

3. The magnetic resonance imaging auxiliary device according to claim 1, characterized in that: in, The object carrying box is integrally formed and recessed on the plane side wall.

4. The magnetic resonance imaging auxiliary device according to claim 1, characterized in that: in, The size of the carrier box is 0.4 cm×2.3 cm×6 cm.

5. The magnetic resonance imaging auxiliary device according to claim 1, characterized in that: in, The planar shape and size of the box cover match the planar side wall. One side of the box cover in the length direction is hinged to one side of the plane side wall in the length direction, and the other side is locked.

6. The magnetic resonance imaging auxiliary device according to claim 5, characterized in that: in, The box cover has a female lock on one side which is locked with the plane side wall. The coil adapting platform has a male locking buckle on this side, The female lock buckle is matched with the male lock buckle for lock-type connection.

7. The magnetic resonance imaging auxiliary device according to claim 1, characterized in that: in, The box cover has a plurality of raised piles on one side close to the coil adapting platform. The position of the protruding pile corresponds to the area where the specimen slice is fixed by the clamping member. When the box cover and the plane side wall are closed, the protruding pile abuts against the specimen slice fixed by the clamping member and presses it against the inner bottom of the object carrier box.

8. The magnetic resonance imaging auxiliary device according to claim 7, characterized in that: in, The protruding height of the protruding pile is not greater than the depth of the object carrying box.

9. A method for improving the quality of magnetic resonance imaging of in vitro specimen slices, characterized in that: The magnetic resonance imaging auxiliary device according to any one of claims 1 to 8 is used, comprising the following steps: S10, placing the ex vivo specimen slice flat in the object box and clamping it with one of the pair of U-shaped protrusions that are adapted to the size of the specimen slice; S20, filling the carrier box with perfluoropolyether grease; S30, closing the box cover and the planar side wall of the coil adapting platform, and the closed surface is attached to the carrier box so as to compact and discharge the air above the specimen slices and / or perfluoropolyether grease in the carrier box; S40, placing a magnetic resonance imaging auxiliary device in the magnetic resonance mouse coil to perform magnetic resonance imaging of the specimen slice.

10. The method for improving the quality of magnetic resonance imaging of in vitro specimen slices according to claim 9, characterized in that: in, In step S40, when magnetic resonance imaging is performed, the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil.

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