Organ storage and transfer box for lung transplantation

Abstract

The invention discloses an organ storage and transfer box for lung transplantation, and relates to the technical field of auxiliary medical instruments. Comprising a box body, a box cover is arranged at the top end of the box body, interlayers are arranged in the box body and on the inner wall of the box cover, the interlayer in the box body and the interlayer on the box cover are enclosed to form a closed central container, the central container is used for placing a lung to be transplanted, and paraffin phase-change materials are arranged in the interlayers. According to the organ storage and transfer box for lung transplantation, in the lung transportation process, the paraffin phase change material is melted to absorb heat, the temperature in the center container is reduced, the temperature in the center container is made to be about 10 DEG C, and the lung storage time is prolonged.

Description

Technical Field

[0001] The present invention relates to the technical field of auxiliary medical equipment, and more particularly to an organ preservation and transport box for lung transplantation. Background Art

[0002] In the emergency department, organ failure is a very serious situation. In this case, it is generally urgent to transplant an organ that matches the patient. During the human organ transplantation process, after obtaining the donor's organ, it may take a long time or a long distance to transport it before it can be transplanted to the patient. During the organ transportation process, temperature control is very important. Constant low temperature is a very important factor in ensuring the activity of the organ. At present, organ transportation is to place dry ice in an ordinary transport box for cooling, and then place the organ in the box. Although the initial temperature in the box can reach the storage temperature of the organ, after a certain period of time, it cannot be guaranteed that the temperature in the box is constant within the storage temperature range. Therefore, it is difficult to ensure the activity of the organ during transportation.

[0003] The lungs are susceptible to damage from various physical and chemical factors, including air pressure, temperature, humidity, etc. Among them, the lungs are particularly sensitive to temperature changes. Hypothermia can reduce cell metabolic activity, reduce cell ATP consumption, and slow down the cell death process, but it can also cause mitochondrial stress and reactive oxygen production, leading to cell peroxidation and aseptic inflammation. Since lung transport requires oxygenation, the lungs produce hypothermic ischemic damage faster than other organs, which is also the main cause of lung dysfunction after transplantation.

[0004] Studies have shown that a sub-hypothermia level of 10 degrees Celsius can slow down the process of cooling blood injury in the lungs, further prolong lung preservation time, and reduce postoperative primary graft failure. However, there is still a lack of a preservation device that can achieve a stable 10-degree Celsius temperature preservation in the clinic. Therefore, how to provide an organ preservation and transportation device that prolongs the lung preservation time is an urgent problem to be solved by those skilled in the art. Summary of the invention

[0005] In view of this, the present invention provides an organ preservation and transport box for lung transplantation, which prolongs the preservation time of the lungs and realizes the long-distance transportation of the lungs. In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0006] The present invention provides an organ preservation and transport box for lung transplantation, comprising:

[0007] A box body, a box cover is arranged on the top of the box body, and interlayers are arranged inside the box body and on the inner wall of the box cover. The interlayers inside the box body and on the box cover are enclosed to form a closed central container, and the central container is used to place the lungs to be transplanted. Paraffin phase change material is arranged in the interlayers.

[0008] Furthermore, a refrigeration system is arranged in the box, and the refrigeration system includes a single-cycle compressor and a heat exchange pipeline. The input end and the output end of the single-cycle compressor are both connected to the heat exchange pipeline. The medium in the heat exchange pipeline is cooled by the single-cycle compressor, and the paraffin phase change material in the interlayer is cooled by the heat exchange pipeline.

[0009] Furthermore, a temperature sensor is arranged in the central container, a temperature recorder is arranged on the box cover, and the temperature sensor is electrically connected to the temperature recorder.

[0010] Furthermore, a position recorder is provided on the box, and the remote geographical location of the organ is tracked by the position recorder.

[0011] Furthermore, the bottom end of the box body is rotatably connected to a wheel axle, both ends of the wheel axle are provided with rollers, and a telescopic pull rod is provided on the box body.

[0012] Furthermore, the refrigeration system also includes a battery pack, and the battery pack is electrically connected to the single-cycle compressor.

[0013] Furthermore, the refrigeration system also includes a power socket, which is electrically connected to the single-cycle compressor. The power socket is connected to an external power source, and the external power source supplies power to the single-cycle compressor through the power socket.

[0014] It can be seen from the above technical solution that, compared with the prior art, the present invention discloses an organ preservation and transport box for lung transplantation. During the transportation of the lungs, the paraffin phase change material absorbs heat to reduce the temperature in the central container to about 10°C, thereby extending the preservation time of the lungs. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0016] Figure 1 A schematic diagram of the structure of an organ preservation and transport box for lung transplantation provided by the present invention;

[0017] Figure 2 This is a time-temperature diagram during lung transport.

[0018] In the figure: 1. power socket; 2. battery pack; 3. single-cycle compressor; 4. heat exchange pipeline; 5. box cover; 6. temperature recorder; 7. position recorder; 8. central container; 9. interlayer; 10. axle; 11. telescopic pull rod. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] See also Figure 1 The embodiment of the present invention discloses an organ preservation and transport box for lung transplantation, comprising:

[0021] The box body has a box cover 5 at the top thereof, and interlayers 9 are arranged inside the box body and on the inner walls of the box cover 5. The interlayers 9 inside the box body and on the box cover 5 are combined to form a closed central container 8, and the central container 8 is used to place the lungs to be transplanted. Paraffin phase change material is arranged in the interlayers 9.

[0022] The paraffin phase change material absorbs heat during the melting process, lowering the temperature inside the central container to around 10°C, thereby extending the preservation time of the lungs.

[0023] In some embodiments, a refrigeration system is provided in the box, and the refrigeration system includes a single-cycle compressor 3 and a heat exchange pipeline 4. The input and output ends of the single-cycle compressor 3 are connected to the heat exchange pipeline 4. The medium in the heat exchange pipeline 4 is cooled by the single-cycle compressor 3, and the paraffin phase change material in the interlayer 9 is cooled by the heat exchange pipeline 4.

[0024] Precooling and temperature control of the central container 8 are achieved by adjusting the refrigeration temperature of the single-cycle compressor 3 .

[0025] The temperature of the single-cycle compressor 3 is set to 2° C. and the paraffin phase change material is kept warm for 3 hours, so that the paraffin phase change material in the interlayer 9 is completely solidified. At this time, the central container 8 can store the perfusion liquid, and the perfusion liquid can be pre-cooled or stored.

[0026] Before the lungs are placed in the central container 8, the temperature of the single-cycle compressor 3 is set to 10°C, and the medium in the heat exchange pipeline 4 is cooled by the single-cycle compressor 3. The cold medium enters the heat exchange pipeline 4 from the single-cycle compressor 3, and the cold medium in the heat exchange pipeline 4 exchanges heat with the paraffin phase change material in the interlayer 9. The temperature of the paraffin phase change material fluctuates between 8-12°C, and the temperature range of the paraffin phase change material is at the critical temperature of the paraffin phase change material. At this time, the temperature in the central container 8 is maintained at 10°C, and the cold medium in the heat exchange pipeline 4 becomes a hot medium after heat exchange. The hot medium enters the single-cycle compressor 3 from the input end of the single-cycle compressor 3, and the hot medium is cooled again by the single-cycle compressor 3.

[0027] When the lungs need to be placed in the central container 8, the packaged lungs are placed in the central container 8 and the single-cycle compressor 3 is turned off. At this time, the paraffin phase change material melts and absorbs a large amount of heat, so that the temperature of the lungs in the central container 8 is maintained at about 10°C, thereby extending the storage time of the lungs and realizing long-distance transportation of the lungs.

[0028] In some embodiments, the interlayer 9 is a polytetrafluoroethylene shell.

[0029] In some embodiments, a temperature sensor is disposed in the central container 8 , a temperature recorder 6 is disposed on the box cover 5 , and the temperature sensor is electrically connected to the temperature recorder 6 .

[0030] The temperature in the central container 8 is measured by a temperature sensor, and the temperature measured by the temperature sensor is recorded by a temperature recorder 6 .

[0031] During the transportation, the temperature recorder 6 records the temperature data measured by the temperature sensor once a minute. The temperature recorder 6 is used to remotely monitor the temperature in the central container 8.

[0032] In some embodiments, a position recorder 7 is provided on the box, and the remote geographical location of the organ is tracked by the position recorder 7.

[0033] During the transportation process, the location information and the temperature information are synchronously recorded and stored in the storage card of the location recorder 7 and the storage card of the temperature recorder 6 respectively, and the contents recorded in the storage card are exported via Bluetooth or directly read.

[0034] In some embodiments, the bottom end of the box is rotatably connected to an axle 10, both ends of the axle 10 are provided with rollers, and a telescopic pull rod 11 is provided on the box.

[0035] The transfer box can be easily moved by rollers and a telescopic pull rod 11 to meet transportation requirements.

[0036] In some embodiments, the refrigeration system further includes a battery pack 2 , and the battery pack 2 is electrically connected to the single-cycle compressor 3 .

[0037] The single-cycle compressor 3 is powered by the battery pack 2 , so that the single-cycle compressor 3 can cool the paraffin phase change material during transportation to ensure the temperature in the central container 8 .

[0038] In some embodiments, the refrigeration system also includes a power socket 1, which is electrically connected to the single-cycle compressor 3. The power socket 1 is connected to an external power source, and the external power source is used to supply power to the single-cycle compressor 3 through the power socket 1.

[0039] During transportation, the power socket 1 is connected to a power source on a vehicle to supply power to the single-cycle compressor 3 .

[0040] In some embodiments, a battery pack socket is also provided, the battery pack socket is electrically connected to the battery pack 2 , and the battery pack socket is connected to an external power source to provide electrical energy to the battery pack 2 , and the electrical energy is stored in the battery pack 2 .

[0041] When returning to the transplant hospital and waiting for the transplant, the single-cycle compressor 3 is powered by the operating room power supply.

[0042] In some embodiments, the capacity of the battery pack 2 is within 100Wh to meet civil aviation transportation regulations.

[0043] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0044] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An organ storage and transport box for lung transplantation, characterized in that: include: A box body, a box cover is arranged on the top of the box body, and interlayers are arranged inside the box body and on the inner wall of the box cover. The interlayers inside the box body and on the box cover are enclosed to form a closed central container, and the central container is used to place the lungs to be transplanted. Paraffin phase change material is arranged in the interlayers.

2. The organ storage and transport box for lung transplantation according to claim 1, characterized in that: A refrigeration system is arranged in the box body, and the refrigeration system includes a single-cycle compressor and a heat exchange pipeline. The input end and the output end of the single-cycle compressor are both connected to the heat exchange pipeline. The medium in the heat exchange pipeline is cooled by the single-cycle compressor, and the paraffin phase change material in the interlayer is cooled by the heat exchange pipeline.

3. The organ storage and transport box for lung transplantation according to claim 1, characterized in that: A temperature sensor is arranged in the central container, a temperature recorder is arranged on the box cover, and the temperature sensor is electrically connected to the temperature recorder.

4. The organ storage and transport box for lung transplantation according to claim 1, characterized in that: The box is provided with a position recorder, through which the remote geographical location of the organ can be tracked.

5. The organ storage and transport box for lung transplantation according to claim 1, characterized in that: The bottom end of the box body is rotatably connected with a wheel axle, both ends of the wheel axle are provided with rollers, and a telescopic pull rod is provided on the box body.

6. The organ storage and transport box for lung transplantation according to claim 2, characterized in that: The refrigeration system further comprises a battery pack, wherein the battery pack is electrically connected to the single-cycle compressor.

7. The organ storage and transport box for lung transplantation according to claim 2, characterized in that: The refrigeration system also includes a power socket, which is electrically connected to the single-cycle compressor. The power socket is connected to an external power source, and the external power source is used to supply power to the single-cycle compressor through the power socket.

Images