Preparation system of functional penis dressing

Abstract

The invention discloses a preparation system of a functional penis dressing, and relates to the technical field of biogel preparation of penis dressings. The device comprises a base, an inner-layer pipe and an outer-layer pipe, the inner-layer pipe and the outer-layer pipe are of concentric double-layer tubular structures and are fixed to the base in a concentric shaft mode, and an inner-outer pipe interlayer is arranged between the inner-layer pipe and the outer-layer pipe; and a piston is arranged in the inner-layer pipe, is tightly connected with the wall of the inner-layer pipe and does not leak air. According to the invention, the base material and the active component form the integrated biogel, and the base material and the active component are separately added, so that the influence of heating on the activity of the active component is avoided; the developed functional penis dressing has a structure similar to that of the penis, and plays a role in slowly releasing bioactive molecules by sleeving the surface of the penis; the preparation system disclosed by the invention is simple in process, easy in reaction control, good in stability, capable of realizing industrialization and wide in popularization prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of biogel preparation of penis dressings, and in particular relates to a preparation system of functional penis dressings. Background Art

[0002] Biogels have broad application prospects as drug carriers in the biomedical field and provide new strategies for the treatment of diseases. For example, they can achieve sustained and controlled release of drugs: encapsulating drugs in gels can prolong the release time of drugs in the body, thereby slowly releasing drugs, improving the efficacy of drugs, and reducing side effects on other parts. In addition, they can improve the efficacy and safety of drugs: through local application and other drug administration methods, gels can evenly disperse drugs and act on specific parts, thereby improving the efficacy of drugs and ensuring the safety of drug use.

[0003] The drug loading methods of biogels mainly include physical embedding / mixing, electrostatic adsorption, covalent anchoring, etc. Among them, the physical embedding / mixing method is to mix the drug directly with the hydrogel solution, and make the drug evenly dispersed in the hydrogel matrix by blending or solvent volatilization. This method is suitable for drugs that are not easy to react chemically with hydrogels. The electrostatic adsorption method controls the electrostatic adsorption force between the hydrogel and the drug so that the drug is firmly adsorbed in the hydrogel. This method is suitable for systems that form complexes through electrostatic interactions, such as directly including naked RNA in the hydrogel, which mainly relies on the electrostatic interaction between RNA and the hydrogel network. The covalent anchoring method covalently links the drug to the functional groups in the hydrogel by chemical cross-linking. This method can improve the stability of the drug and ensure the uniform distribution of the drug in the hydrogel. For example, a stimuli-responsive segment design is introduced into the photocurable hydrogel, or an intermediate bridge for coupling the drug is introduced to anchor the drug. However, none of these loading methods can be used immediately, and how to achieve drug loading in a short period of time is still a great challenge. Penis gel generally refers to gel products used for male private parts care or treatment of certain male reproductive system related problems. Such products may contain a variety of ingredients, such as human lubricants, Chinese medicine ingredients, etc., aimed at treating diseases, improving the quality of life, etc. Currently, penis gels on the market are mainly used before sexual intercourse and do not have the function of daily medical beauty. However, as people pursue a better and healthier life, the development of penis gels with health care functions and used for daily medical beauty has good economic and social benefits.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a preparation system for a functional penis dressing.

[0006] In order to solve the above technical problems, the basic concept of the technical solution adopted by the present invention is:

[0007] A preparation system for a functional penis dressing comprises a base, an inner tube and an outer tube, wherein the inner tube and the outer tube are concentric double-layer tubular structures and are fixed to the base in a concentric axis manner, wherein an inner and outer tube sandwich is provided between the inner tube and the outer tube;

[0008] A piston is arranged inside the inner tube, and the piston is tightly connected to the wall of the inner tube without leakage;

[0009] The inner tube wall is provided with numerous micrometer-sized pores for the active ingredient solution to penetrate into the outer tube interlayer.

[0010] Optionally, the thickness of the inner tube is 1 mm, the inner diameter is 30 mm, and the length is 150 mm; the inner diameter of the outer tube is 36 mm, and the length is 150 mm.

[0011] Optionally, the inner tube, the outer tube and the base cannot be made of plastic, stainless steel, ceramic or glass, and plastic includes acrylic (PMMA), polydimethylsiloxane (PDMS), polystyrene (PS) or ABS.

[0012] Optionally, the temperature-sensitive biopolymer material includes one or more of gelatin, carrageenan, elastin polypeptide, chitosan, methylcellulose, hydroxypropyl methylcellulose or xyloglucan.

[0013] Optionally, the bioactive molecule solution includes one or more of cells, cytokines, cell supernatant, protein solution, polypeptide solution or exosome solution.

[0014] Optionally, the amount of the bioactive molecule solution used at one time is 1-5 mL.

[0015] Optionally, a preparation system of a functional penis dressing is characterized in that the specific method of use comprises the following steps:

[0016] Step 1: Heat and dissolve the thermosensitive biopolymer material in a solvent, and pour it into the inner and outer tube sandwich after forming a fluid state;

[0017] Step 2: Add a bioactive molecule solution into the inner tube, and push the piston to allow the solution to penetrate into the inner and outer tube interlayers through the pores;

[0018] Step 3: During the solidification process of the thermosensitive biopolymer material, the thermosensitive biopolymer material is integrated with the bioactive molecules to finally obtain a biogel with surface functional modification.

[0019] Optionally, the dissolving temperature of the thermosensitive biopolymer material is 60-80°C, and the solidification process is carried out at an ambient temperature of 20-25°C.

[0020] Optionally, the bioactive molecule solution penetrates into the inner and outer tube interlayers through the mechanical pressure of the piston, and forms a physical mixing or electrostatic adsorption loading structure with the temperature-sensitive material.

[0021] Optionally, the surface functionally modified biogel has a size that matches the physiological structure of the penis to form a putable sustained-release dressing.

[0022] After adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art. Of course, any product implementing the present invention does not necessarily need to achieve all the advantages described below at the same time:

[0023] The present invention forms an integrated biogel with basic materials and active ingredients, and adds the basic materials and active ingredients separately, thereby avoiding the influence of heating on the activity of the active ingredients; and the developed functional penis dressing has a structure similar to that of the penis, and plays a role in sustained release of bioactive molecules by being inserted into the surface of the penis; the preparation system of the present invention has a simple process, easy-to-control reaction, good stability, and can be industrialized, and has broad promotion prospects.

[0024] The specific implementation modes of the present invention are further described in detail below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The drawings described below are only some embodiments. For those skilled in the art, other drawings can be obtained based on these drawings without creative work. In the drawings:

[0026] Figure 1 This is a schematic diagram of the outer tube structure of an embodiment of the present invention;

[0027] Figure 2 This is a schematic diagram of the inner tube structure according to an embodiment of the present invention;

[0028] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0029] 1-base; 2-inner tube; 3-outer tube; 4-piston; 5-inner and outer tube sandwich.

[0030] It should be noted that these drawings and textual descriptions are not intended to limit the conceptual scope of the present invention in any way, but are intended to illustrate the concept of the present invention for those skilled in the art by referring to specific embodiments. DETAILED DESCRIPTION

[0031] The present invention will now be described in further detail with reference to the accompanying drawings.

[0032] Embodiment 1:

[0033] As shown in the figure, in this embodiment, a preparation system of a functional penis dressing is provided, including a base 1, an inner tube 2 and an outer tube 3, wherein the inner tube 2 and the outer tube 3 are concentric double-layer tubular structures, and the two are fixed to the base 1 in a concentric axis manner, wherein an inner and outer tube interlayer 5 is provided between the inner tube 2 and the outer tube 3;

[0034] A piston 4 is arranged inside the inner tube 2, and the piston 4 is tightly connected to the wall of the inner tube 2 without leaking;

[0035] Numerous micrometer-sized pores are arranged in the wall of the inner tube 2 for the active ingredient solution to penetrate into the outer tube interlayer 5 .

[0036] The present invention forms an integrated biogel with basic materials and active ingredients, and adds the basic materials and active ingredients separately, thereby avoiding the influence of heating on the activity of the active ingredients; and the developed functional penis dressing has a structure similar to that of the penis, and plays a role in sustained release of bioactive molecules by being inserted into the surface of the penis; the preparation system of the present invention has a simple process, easy-to-control reaction, good stability, and can be industrialized, and has broad promotion prospects.

[0037] like Figure 2 As shown, the inner tube 2 of this embodiment has a thickness of 1 mm, an inner diameter of 30 mm, and a length of 150 mm; the inner diameter of the outer tube 3 is 36 mm, and the length is 150 mm.

[0038] like Figure 2 As shown, the inner tube 2, the outer tube 3 and the base 1 of this embodiment can be made of plastic, stainless steel, ceramic or glass, and the plastic includes acrylic (PMMA), polydimethylsiloxane (PDMS), polystyrene (PS) or ABS.

[0039] The temperature-sensitive biopolymer material of this embodiment includes one or more of gelatin, carrageenan, elastin polypeptide, chitosan, methyl cellulose, hydroxypropyl methyl cellulose or xyloglucan.

[0040] The bioactive molecule solution of this embodiment includes one or more of cells, cytokines, cell supernatant, protein solution, polypeptide solution or exosome solution.

[0041] The amount of the bioactive molecule solution used at one time in this embodiment is 1-5 mL.

[0042] A preparation system of a functional penis dressing, characterized in that a specific use method comprises the following steps:

[0043] Step 1: Heat and dissolve the thermosensitive biopolymer material in a solvent to form a fluid state and then pour it into the inner and outer tube sandwich 5;

[0044] Step 2: Add a bioactive molecule solution into the inner tube 2, and push the piston 4 to allow the solution to penetrate into the inner and outer tube interlayer 5 through the pores;

[0045] Step 3: During the solidification process of the thermosensitive biopolymer material, the thermosensitive biopolymer material is integrated with the bioactive molecules to finally obtain a biogel with surface functional modification.

[0046] The dissolution temperature of the thermosensitive biopolymer material of this embodiment is 60-80°C, and the solidification process is carried out at an ambient temperature of 20-25°C; the bioactive molecule solution penetrates into the inner and outer tube interlayer 5 through the mechanical pressure of the piston 4, forming a physical mixing or electrostatic adsorption load structure with the thermosensitive material; the surface functionally modified biogel has a size that matches the physiological structure of the penis, forming a putable sustained-release dressing.

[0047] Example 2: The inner and outer tubes 2 are made of stainless steel and fixed on a stainless steel base in a concentric manner to form a sandwich with a thickness of 2 mm between the inner and outer tubes; a silicone piston is inserted into the inner tube to ensure that the piston is tightly connected to the inner tube wall and does not leak.

[0048] Example 3: Carrageenan is used as a thermosensitive biopolymer material, and a 10% solution of 50 mL is prepared and heated to 80°C to dissolve. The carrageenan solution is poured into the interlayer between the inner and outer tubes while hot. 5 mL of cell supernatant is added to the inner tube, and the piston is pushed in so that the active ingredient solution penetrates into the interlayer between the inner and outer tubes through the pores. During the coagulation process of carrageenan, the carrageenan and the cell supernatant are integrated, and finally a biogel with surface functional modification is prepared.

[0049] Example 4: Gelatin is used as a thermosensitive biopolymer material, and a 30% solution of 50 mL is prepared and heated to 80°C to dissolve. The gelatin solution is poured into the interlayer between the inner and outer tubes while hot. 3 mL of polypeptide solution is added to the inner tube, and the piston 4 is pushed in, so that the active ingredient solution penetrates into the interlayer between the inner and outer tubes through the pores. During the gelatin solidification process, the gelatin and polypeptide solution are integrated, and finally a biogel with surface functional modification is prepared.

[0050] The present invention is not limited to the above-mentioned embodiments. Anyone should be aware that any structural changes made under the enlightenment of the present invention, and any technical solutions that are the same or similar to the present invention, fall within the protection scope of the present invention. The technology, shape, and structural parts not described in detail in the present invention are all well-known technologies.

Claims

1. A preparation system for a functional penis dressing, characterized in that: include: A base (1), an inner tube (2) and an outer tube (3), wherein the inner tube (2) and the outer tube (3) are concentric double-layer tubular structures and are fixed to the base (1) in a concentric axis manner, wherein an inner and outer tube sandwich (5) is provided between the inner tube (2) and the outer tube (3); A piston (4) is arranged inside the inner tube (2), and the piston (4) is tightly connected to the wall of the inner tube (2) without leaking air; Numerous micrometer-level pores are arranged in the wall of the inner tube (2) for the active ingredient solution to penetrate into the outer tube interlayer (5).

2. A preparation system for a functional penis dressing according to claim 1, characterized in that: The inner layer pipe (2) has a thickness of 1 mm, an inner diameter of 30 mm and a length of 150 mm; the outer layer pipe (3) has an inner diameter of 36 mm and a length of 150 mm.

3. A preparation system for a functional penis dressing according to claim 1, characterized in that: The inner tube (2), the outer tube (3) and the base (1) can all be made of plastic, stainless steel, ceramic or glass. The plastic includes acrylic (PMMA), polydimethylsiloxane (PDMS), polystyrene (PS) or ABS.

4. A preparation system for a functional penis dressing according to claim 1, characterized in that: The thermosensitive biopolymer material includes one or more of gelatin, carrageenan, elastin polypeptide, chitosan, methyl cellulose, hydroxypropyl methyl cellulose or xyloglucan.

5. The preparation system of a functional penis dressing according to claim 1, characterized in that: The bioactive molecule solution includes one or more of cells, cytokines, cell supernatant, protein solution, polypeptide solution or exosome solution.

6. A preparation system for a functional penis dressing according to claim 1, characterized in that: The amount of the bioactive molecule solution used at one time is 1-5 mL.

7. A preparation system for a functional penis dressing according to claim 1, characterized in that: The specific usage includes the following steps: Step 1: Heat and dissolve the temperature-sensitive biopolymer material in a solvent, and pour it into the inner and outer tube sandwich (5) after forming a fluid state; Step 2: Add a bioactive molecule solution into the inner tube (2), and push the solution through the piston (4) to penetrate into the inner and outer tube interlayers (5) through the pores; Step 3: During the solidification process of the thermosensitive biopolymer material, the thermosensitive biopolymer material is integrated with the bioactive molecules to finally obtain a biogel with surface functional modification.

8. A system for preparing a functional penis dressing according to claim 7, characterized in that: The dissolving temperature of the thermosensitive biopolymer material is 60-80°C, and the solidification process is carried out at an ambient temperature of 20-25°C.

9. A preparation system for a functional penis dressing according to claim 7, characterized in that: The bioactive molecule solution permeates into the inner and outer tube interlayers (5) through the mechanical pressure of the piston (4), and forms a physical mixing or electrostatic adsorption loading structure with the temperature-sensitive material.

10. The preparation system of a functional penis dressing according to claim 7, characterized in that: The surface functionally modified biogel has a size that matches the physiological structure of the penis, forming a putable sustained-release dressing.

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