Application of hibiscus manihot carbon quantum dots in preparation of cosmetic preservative system

Abstract

The invention discloses application of hibiscus manihot carbon quantum dots in preparation of a cosmetic anticorrosion system, and the hibiscus manihot carbon quantum dots are compounded with classical anticorrosion combination phenoxyethanol and CHA, so that the addition amount of phenoxyethanol is properly reduced. The compounding mode not only can play a good preservative effect, but also can remarkably reduce the problem of skin sensitivity caused by phenoxyethanol. Therefore, the compound system can be used as a novel preservative system to be applied to cosmetic formulas.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetic preservative systems, and particularly relates to use of Hibiscus sibiricus carbon quantum dots in preparing cosmetic preservative systems. Background Art

[0002] Phenoxyethanol is a classic preservative that is widely used in cosmetics and personal care products due to its good preservative effect. It can effectively inhibit the growth of microorganisms and extend the shelf life of products. However, the sensitization rate of phenoxyethanol is relatively high, which makes it risky during use. Studies have shown that the sensitization rate of phenoxyethanol is about 2.5%. Although this ratio is not extremely high, it may still cause allergic reactions in some sensitive people.

[0003] In order to reduce the risk of allergies while maintaining good antiseptic effects, the compound application of natural antiseptic materials has received more and more attention in recent years. By rationally combining a variety of natural antiseptic materials, not only can the antiseptic performance be enhanced, but the occurrence of allergies can also be significantly reduced. The development of this natural antiseptic system provides a safer and more environmentally friendly option for the cosmetics industry.

[0004] The chemical composition of phenoxyethanol is 2-phenoxyethanol, which is a free-flowing colorless liquid with a light aromatic smell. As an organic synthetic compound, phenoxyethanol has a broad-spectrum antibacterial effect and can effectively inhibit the growth of bacteria, molds and yeasts. In particular, for Gram-negative bacteria, such as Pseudomonas, the bactericidal effect of phenoxyethanol is particularly significant. In addition, phenoxyethanol has good formulation compatibility with other preservatives or preservative enhancers, which enables it to be widely used in a variety of products. Phenoxyethanol has been used as a preservative in cosmetics since the 1950s and has a long history of use.

[0005] However, the safety of phenoxyethanol has gradually attracted people's attention. Studies have shown that phenoxyethanol may cause strong irritation to the eyes and skin, and even cause blisters. Phenoxyethanol may also be harmful to human health if ingested or inhaled. The cosmetics database rates its harmfulness as moderate and warns of possible cancer, allergic reactions, and irritation to the skin, eyes, and lungs. In addition, animal experiments have shown that phenoxyethanol may affect sensory function even at low doses; moderate doses may affect the brain and nervous system, and even cause cell mutations.

[0006] In contrast, natural extracts with antibacterial effects are more gentle, hypoallergenic, green and healthy. These natural extracts are mainly derived from polyphenols, flavonoids, saponins, alkaloids, organic acids and other substances in plants. Through the synergistic effect of these natural ingredients, good antibacterial effects can be achieved. For example, the methanol extract of yellow peel leaves has good antibacterial activity against a variety of plant pathogenic fungi and animal pathogenic bacteria, and its active ingredients are mainly found in petroleum ether extracts. In addition, the chlorogenic acid extract of Eucommia ulmoides leaves also exhibits strong antibacterial activity and antioxidant effects. Although natural extracts have many advantages, a single plant preservative system often has problems such as poor antibacterial effect and narrow antibacterial spectrum. Summary of the invention

[0007] The present invention aims to overcome the defects of the prior art and provide the use of Hibiscus sibiricus carbon quantum dots in the preparation of a cosmetic preservative system.

[0008] The technical solution of the present invention is as follows:

[0009] The invention discloses use of hibiscus rosa-sinensis carbon quantum dots in preparing a cosmetic preservative system. The cosmetic preservative system comprises hibiscus rosa-sinensis carbon quantum dots solution, phenoxyethanol and CHA.

[0010] In a preferred embodiment of the present invention, the method for preparing the Hibiscus sibiricum carbon quantum dot solution comprises:

[0011] (1) crushing the rhizome of Hibiscus tiliaceus into fine powder and sieving it to obtain Hibiscus tiliaceus powder;

[0012] (2) firing the Hibiscus sibiricum powder obtained in step (1) until the Hibiscus sibiricum powder is carbonized and its color changes to dark brown, and cooling to room temperature to obtain carbonized Hibiscus sibiricum powder;

[0013] (3) mixing the carbonized Hibiscus sibiricum powder obtained in step (2) with ultrapure water at a mass ratio of 1:100, then ultrasonically treating the mixture at 40 kHz, and then immediately centrifuging the mixture to remove undissolved solid impurities, thereby obtaining a supernatant;

[0014] (4) The supernatant obtained in step (3) is filtered using a microporous filter membrane to obtain a brown, clear, Hibiscus suffruticosa carbon quantum dot solution.

[0015] Further preferably, in the cosmetic preservative, the mass ratio of the Hibiscus sibiricum carbon quantum dot solution, phenoxyethanol and CHA is 2-3:2-3:0.4-0.6.

[0016] A cosmetic preservative system is prepared by compounding raw materials including hibiscus carbon quantum dot solution, phenoxyethanol and CHA.

[0017] In a preferred embodiment of the present invention, the method for preparing the Hibiscus sibiricum carbon quantum dot solution comprises:

[0018] (1) crushing the rhizome of Hibiscus tiliaceus into fine powder and sieving it to obtain Hibiscus tiliaceus powder;

[0019] (2) firing the Hibiscus sibiricum powder obtained in step (1) until the Hibiscus sibiricum powder is carbonized and its color changes to dark brown, and cooling to room temperature to obtain carbonized Hibiscus sibiricum powder;

[0020] (3) mixing the carbonized Hibiscus sibiricum powder obtained in step (2) with ultrapure water at a mass ratio of 1:100, then ultrasonically treating the mixture at 40 kHz, and then immediately centrifuging the mixture to remove undissolved solid impurities, thereby obtaining a supernatant;

[0021] (4) The supernatant obtained in step (3) is filtered using a microporous filter membrane to obtain a brown, clear, Hibiscus suffruticosa carbon quantum dot solution.

[0022] Further preferably, the mass ratio of the Hibiscus sibiricum carbon quantum dot solution, phenoxyethanol and CHA is 2-3:2-3:0.4-0.6.

[0023] Use of the above cosmetic preservative system in preparing cosmetic compositions.

[0024] In a preferred embodiment of the present invention, the content of the cosmetic preservative system in the cosmetic composition is 5.05 wt %.

[0025] A cosmetic composition comprises the above-mentioned cosmetic preservative system.

[0026] In a preferred embodiment of the present invention, the content of the cosmetic preservative system therein is 5.05 wt%.

[0027] The beneficial effect of the present invention is that the present invention appropriately reduces the amount of phenoxyethanol added by compounding the Hibiscus sibiricum carbon quantum dots with the classic antiseptic combination of phenoxyethanol and CHA. This compounding method can not only exert a good antiseptic effect, but also significantly reduce the skin sensitivity problem caused by phenoxyethanol. Therefore, the compounding system can be used as a new antiseptic system in cosmetic formulas. DETAILED DESCRIPTION

[0028] The technical solution of the present invention is further illustrated and described below through specific implementation methods.

[0029] Example 1

[0030] (1) crushing the rhizome of Hibiscus tiliaceus into fine powder using a grinder and then sieving to obtain Hibiscus tiliaceus powder;

[0031] (2) placing the Hibiscus sibiricum powder obtained in step (1) into a crucible, calcining at 200° C. for 2 h to carbonize the Hibiscus sibiricum powder and turning it into dark brown, and cooling it to room temperature to obtain carbonized Hibiscus sibiricum powder;

[0032] (3) mixing the carbonized Hibiscus sibiricum powder obtained in step (2) with ultrapure water at a mass ratio of 1:100, then ultrasonically treating the mixture at 40 kHz for 2 h, and then immediately centrifuging at 5000 rpm to remove undissolved solid impurities to obtain a supernatant;

[0033] (4) The supernatant obtained in step (3) was filtered using a 0.22 μm microporous filter membrane to obtain a brown, clear, Hibiscus suffruticosa carbon quantum dot solution.

[0034] Example 2

[0035] Six groups of anti-corrosion systems were prepared based on the Hibiscus sibiricum carbon quantum dot solution prepared in Example 1 for experiments:

[0036] Group 1 (phenoxyethanol 0.5%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0%)

[0037] Group 2 (phenoxyethanol 0.3%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0%)

[0038] Group 3 (phenoxyethanol 0.3%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0.2%)

[0039] Group 4 (phenoxyethanol 0.2%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0%)

[0040] Group 5 (phenoxyethanol 0.2%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0.3%)

[0041] Group 6 (phenoxyethanol 0%, CHA 0.05%, Hibiscus sibiricum carbon quantum dot solution 0.5%)

[0042] This example refers to the "Technical Guidelines for Challenge Test Evaluation of Cosmetic Preservatives". The colony counts of 6 groups of samples were tested after 7 days, 14 days and 28 days respectively. The microbial content in the samples at each time point was calculated. The logarithmic reduction value of the microbial content was used to determine whether the sample passed the standard. Finally, the antiseptic effect of the 6 groups of samples was evaluated, i.e., an antiseptic challenge experiment was conducted. The specific experiment is as follows:

[0043] (1) Experimental methods:

[0044] Reference was made to the "Technical Guidelines for Challenge Testing and Evaluation of Cosmetic Preservatives" issued by the China Food and Drug Inspection Institute.

[0045] Microbial challenge tests are often used in cosmetic preservative efficacy evaluation tests, which involves artificially contaminating cosmetics with a certain amount of microorganisms to simulate possible cosmetic contamination, testing the amount of surviving bacteria at regular intervals, and evaluating the effectiveness of the cosmetic preservative system based on changes in the amount of surviving bacteria. Commonly used strains in the test include Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Aspergillus niger, and Candida albicans.

[0046] Weigh a certain amount of test sample and add the test microorganism to the test sample. The amount of microorganism should not exceed 1% of the sample amount. The final microbial content in the sample is 10 5 ~10 6 cfu / g (bacteria) 10 4 ~10 5 cfu / g (fungi); after culturing the samples for 7, 14, and 28 days, a certain amount of samples were taken out to determine the microbial content; the microbial content in the samples at each time point was calculated, and whether it passed the standard was determined based on the logarithmic reduction value of the microbial content.

[0047] The logarithmic reduction value (R x ) is used as the evaluation index, and the calculation method is shown in formula (1):

[0048] R x =lgN 0 -lgN x

[0049] Where:

[0050] N 0 ——Initial bacterial contamination of the test sample.

[0051] N x ——The number of surviving bacteria in the test sample at different detection times

[0052] Table 1 Calculation and standard of anticorrosion challenge test results

[0053]

[0054] The above 6 groups of samples were subjected to preservative challenge tests in accordance with the Technical Guidelines for Challenge Test Evaluation of Cosmetic Preservatives. After culturing the samples for 7, 14, and 28 days, a certain amount of samples were taken out to determine the microbial content. The microbial content in the samples at each time point was calculated, and whether the standards were passed was determined based on the logarithmic reduction value of the microbial content. The result calculation and standards are shown in Table 1.

[0055] (2) Experimental results:

[0056] The experimental results are shown in Table 2 below:

[0057] Table 2

[0058]

[0059]

[0060] *Uncountable: The number is too large to be counted, indicating that the active ingredient cannot inhibit the growth of microorganisms.

[0061] Example 3 Allergy test

[0062] (1) Mask preparation:

[0063] Control group (glycerol 5%, sodium hyaluronate 0.15%, dipotassium glycyrrhizinate 0.2%, water 94.65%)

[0064] Group 1 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Phenoxyethanol 0.5%, CHA 0.05%, Water 94.1%)

[0065] Group 2 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Phenoxyethanol 0.3%, CHA 0.05%, Water 94.3%)

[0066] Group 3 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Phenoxyethanol 0.3%, Hibiscus Carbon Quantum Dots 0.2%, CHA 0.05%, Water 94.1%)

[0067] Group 4 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Phenoxyethanol 0.2%, CHA 0.05%, Water 94.4%)

[0068] Group 5 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Phenoxyethanol 0.2%, Hibiscus Carbon Quantum Dots 0.3%, CHA 0.05%, Water 94.1%)

[0069] Group 6 (Glycerin 5%, Sodium Hyaluronate 0.15%, Dipotassium Glycyrrhizate 0.2%, Hibiscus Carbon Quantum Dots 0.5%, CHA 0.05%, Water 94.1%)

[0070] (2) Experimental method: A questionnaire was used to screen for sensitive skin (Sensitive-S) vs. tolerant skin (Rensistant-R) in Dr. Bergman's 16-type skin classification test, and 70 people with scores greater than 30 were selected as test subjects. The subjects were randomly divided into 7 groups and the 7 groups of facial masks were tested separately for 3 days, one mask per day, without using any other products during the test.

[0071] (3) Experimental results: As shown in Table 3:

[0072] Table 3

[0073] Control group Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Number of people with allergies 0 4 3 2 2 1 0 Allergy rate 0 4 / 10 3 / 10 2 / 10 2 / 10 1 / 10 0

[0074] The above description is only a preferred embodiment of the present invention, and therefore cannot be used to limit the scope of the present invention. That is, equivalent changes and modifications made according to the patent scope of the present invention and the contents of the specification should still fall within the scope of the present invention.

Claims

1. The use of Hibiscus sibiricum carbon quantum dots in the preparation of cosmetic preservative systems, characterized in that: The cosmetic preservative system comprises hibiscus carbon quantum dot solution, phenoxyethanol and CHA.

2. The use according to claim 1, characterized in that: The preparation method of the Hibiscus serrata carbon quantum dot solution comprises: (1) crushing the rhizome of Hibiscus tiliaceus into fine powder and sieving it to obtain Hibiscus tiliaceus powder; (2) firing the Hibiscus sibiricum powder obtained in step (1) until the Hibiscus sibiricum powder is carbonized and its color changes to dark brown, and cooling to room temperature to obtain carbonized Hibiscus sibiricum powder; (3) mixing the carbonized Hibiscus sibiricum powder obtained in step (2) with ultrapure water at a mass ratio of 1:100, then ultrasonically treating the mixture at 40 kHz, and then immediately centrifuging the mixture to remove undissolved solid impurities, thereby obtaining a supernatant; (4) The supernatant obtained in step (3) is filtered using a microporous filter membrane to obtain a brown, clear, Hibiscus suffruticosa carbon quantum dot solution.

3. The use according to claim 2, characterized in that: In the cosmetic preservative, the mass ratio of the Hibiscus sibiricum carbon quantum dot solution, phenoxyethanol and CHA is 2-3:2-3:0.4-0.

6.

4. A cosmetic preservative system, characterized in that: It is compounded from raw materials including Hibiscus suffruticosa carbon quantum dot solution, phenoxyethanol and CHA.

5. A cosmetic preservative system according to claim 4, characterized in that: The preparation method of the Hibiscus serrata carbon quantum dot solution comprises: (1) crushing the rhizome of Hibiscus tiliaceus into fine powder and sieving it to obtain Hibiscus tiliaceus powder; (2) firing the Hibiscus sibiricum powder obtained in step (1) until the Hibiscus sibiricum powder is carbonized and its color changes to dark brown, and cooling to room temperature to obtain carbonized Hibiscus sibiricum powder; (3) mixing the carbonized Hibiscus sibiricum powder obtained in step (2) with ultrapure water at a mass ratio of 1:100, then ultrasonically treating the mixture at 40 kHz, and then immediately centrifuging the mixture to remove undissolved solid impurities, thereby obtaining a supernatant; (4) The supernatant obtained in step (3) is filtered using a microporous filter membrane to obtain a brown, clear, Hibiscus suffruticosa carbon quantum dot solution.

6. A cosmetic preservative system according to claim 5, characterized in that: The mass ratio of the Hibiscus sibiricus carbon quantum dot solution, phenoxyethanol and CHA is 2-3:2-3:0.4-0.

6.

7. Use of the cosmetic preservative system according to any one of claims 4 to 6 in the preparation of a cosmetic composition.

8. The use according to claim 7, characterized in that: The content of the cosmetic preservative system in the cosmetic composition is 5.05 wt %.

9. A cosmetic composition, characterized in that: A cosmetic preservative system according to any one of claims 4 to 6.

10. A cosmetic composition according to claim 9, characterized in that: The content of the cosmetic preservative system therein is 5.05 wt %.

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