Scald ointment and preparation method thereof

Abstract

The invention relates to the technical field of scald ointment, in particular to scald ointment and a preparation method thereof.The scald ointment is prepared from, by weight, 60%-90% of water, 1%-30% of lime and 5%-15% of sesame oil.The invention provides a scald first-aid scheme which is low in cost and easy to prepare; the irritation to damaged skin is obviously reduced while certain antibacterial activity is maintained; the formation of the pH gradient is beneficial to gradually adjusting and optimizing the viscosity and the water evaporation rate of a wound surface microenvironment, so that the good smearing property and the moderate wetting effect of the preparation are ensured; the synergistic effect of sesame oil and lime may provide unique anti-oxidation and cell repair support.

Description

Technical Field

[0001] The invention relates to the technical field of scald ointment, in particular to a scald ointment and a preparation method thereof. Background Art

[0002] Burns are a common type of trauma, and their treatment has always been a focus of medical attention. Traditional burn treatment methods usually include cold compresses, anti-infection, and healing promotion. However, existing burn ointment preparations often have some limitations. First, many commercial burn ointments have complex ingredients and high production costs, which are not conducive to rapid use in emergency treatment. Secondly, some preparations may irritate damaged skin and delay the healing process. Furthermore, it is difficult to balance the antibacterial effect and healing promotion effect of some burn ointments, and one is often lost while the other is taken into account.

[0003] The closest existing technologies usually use antibiotics, hormone drugs or natural plant extracts as the main active ingredients. Although these methods are excellent in some aspects, they still face problems such as drug resistance, side effects or high costs. Especially in emergency situations, these complex formulations may be difficult to obtain quickly or use correctly. Summary of the invention

[0004] The present invention aims to solve the above technical problems and provide a simple, easily available and effective burn ointment and a preparation method thereof. The core innovation of the present invention is to skillfully combine three common raw materials, water, lime and sesame oil, and achieve synergistic effects among the components through precisely controlled proportions and preparation processes.

[0005] The object of the present invention is to provide a burn ointment, comprising the following components in percentage by weight:

[0006] Water: 60-90%,

[0007] Lime: 1-30%,

[0008] Sesame oil: 5-15%.

[0009] Specifically, the water content is 70-80%.

[0010] Specifically, the content of lime is 5-15%.

[0011] Specifically, the content of sesame oil is 8-12%.

[0012] The preparation method of the burn ointment comprises the following steps:

[0013] (1) First, add the water into a stirring container;

[0014] (2) Secondly, slowly add the lime under continuous stirring;

[0015] (3) Then, continue stirring until the lime is completely dispersed;

[0016] (4) Again, slowly adding the sesame oil under continuous stirring;

[0017] (5) Finally, stir until a uniform paste is formed.

[0018] Specifically, the rate of adding lime in step (2) is no more than 10% of the total amount of lime per minute.

[0019] Specifically, the stirring time in step (3) is 15-30 minutes.

[0020] Specifically, the rate of adding sesame oil in step (4) is no more than 15% of the total sesame oil per minute.

[0021] Specifically, the stirring time in step (5) is 20-40 minutes.

[0022] Specifically, the stirring speed is 200-400 rpm.

[0023] From the perspective of chemical mechanism, the uniqueness of the present invention is first reflected in the interaction between lime (the main component is calcium hydroxide, Ca(OH)2) and water. When lime is dissolved in water, the following reaction occurs:

[0024] Ca(OH)2→Ca 2 ++2OH-

[0025] This process not only provides an alkaline environment, which helps soften necrotic tissue, but also releases calcium ions, which play a key role in cell signaling and coagulation.

[0026] Secondly, the abundant unsaturated fatty acids in sesame oil (such as linoleic acid, linolenic acid, etc.) play multiple roles in this system. The carboxyl groups (-COOH) of these fatty acids may partially complex with calcium ions:

[0027] 2R-COOH+Ca 2 +→(R-COO)2Ca+2H+

[0028] This reaction not only alleviates the strong alkalinity of the system, but also forms a unique colloidal structure, which is beneficial to the stability and adhesion of the preparation.

[0029] What’s more interesting is that the unsaturated fatty acids in sesame oil may react with hydroxyl radicals in water through their double bonds, thus playing a certain antioxidant role:

[0030] R-CH=CH-R'+·OH→R-CH(OH)-CH·-R'

[0031] This process may help reduce oxidative stress damage caused by burns.

[0032] In the preparation method of the present invention, the precise control of stirring speed and time ensures the uniform dispersion and full reaction of each component. This process innovation enables the final product to have an ideal pH gradient, moderate viscosity and optimized water regulation ability.

[0033] In summary, the present invention achieves the following through the ingenious combination of simple raw materials and precise preparation process:

[0034] Beneficial effects:

[0035] 1. Provides a low-cost, easy-to-prepare first aid solution for burns;

[0036] 2. While maintaining a certain antibacterial activity, it significantly reduces the irritation to damaged skin;

[0037] 3. The formation of pH gradient is conducive to the gradual regulation of the wound microenvironment;

[0038] 4. The optimized viscosity and water evaporation rate ensure good spreadability and moderate wetting effect of the preparation;

[0039] 5. The synergistic effect of sesame oil and lime may provide unique antioxidant and cell repair support.

[0040] The comprehensive manifestation of these effects makes the present invention show unique application prospects in first aid and subsequent treatment of burns, and provides a new idea and choice for burn treatment. DETAILED DESCRIPTION

[0041] Example 1

[0042] This embodiment provides a burn ointment and a preparation method thereof. The burn ointment comprises the following components in weight percentage: 60% water, 30% lime, and 10% sesame oil.

[0043] The preparation method comprises the following steps:

[0044] (1) First, 60 parts by weight of water were added into a stirring container;

[0045] (2) Next, 30 parts by weight of lime were slowly added at a rate of 3 parts by weight per minute at a stirring speed of 200 rpm;

[0046] (3) Then, continue stirring at 200 rpm for 15 minutes until the lime is completely dispersed;

[0047] (4) Again, maintaining a stirring speed of 200 rpm, 10 parts by weight of sesame oil were slowly added at a rate of 1 part by weight per minute;

[0048] (5) Finally, stir at 200 rpm for 20 minutes until a uniform paste is formed.

[0049] In this embodiment, a higher proportion of lime may provide a strong alkaline environment, which may theoretically have a stronger antibacterial effect. However, users should be aware that high concentrations of lime may cause irritation to the skin.

[0050] Embodiment 2:

[0051] This embodiment provides another burn ointment and a preparation method thereof. The burn ointment comprises the following components in weight percentage: 80% water, 5% lime, and 15% sesame oil.

[0052] The preparation method comprises the following steps:

[0053] (1) First, 80 parts by weight of water were added into a stirring container;

[0054] (2) Next, 5 parts by weight of lime were slowly added at a rate of 0.5 parts by weight per minute at a stirring speed of 300 rpm;

[0055] (3) Then, continue stirring at 300 rpm for 22 minutes until the lime is completely dispersed;

[0056] (4) Again, maintaining a stirring speed of 300 rpm, 15 parts by weight of sesame oil was slowly added at a rate of 2 parts by weight per minute;

[0057] (5) Finally, stir at 300 rpm for 30 minutes until a uniform paste is formed.

[0058] In this example, a higher ratio of water and sesame oil may make the formulation have better fluidity and moisturizing properties. A lower ratio of lime may reduce irritation to the skin while still maintaining a slightly alkaline environment.

[0059] Embodiment 3:

[0060] This embodiment provides a third burn ointment and a preparation method thereof. The burn ointment comprises the following components in weight percentage: 75% water, 15% lime, and 10% sesame oil.

[0061] The preparation method comprises the following steps:

[0062] (1) First, 75 parts by weight of water were added to a stirring container;

[0063] (2) Next, 15 parts by weight of lime were slowly added at a rate of 1.5 parts by weight per minute at a stirring speed of 350 rpm;

[0064] (3) Then, continue stirring at 350 rpm for 25 minutes until the lime is completely dispersed;

[0065] (4) Again, maintaining a stirring speed of 350 rpm, 10 parts by weight of sesame oil was slowly added at a rate of 1.5 parts by weight per minute;

[0066] (5) Finally, stir at 350 rpm for 35 minutes until a uniform paste is formed.

[0067] In this example, the moderate proportion of lime may provide an alkaline environment while reducing potential irritation to the skin. The appropriate amount of sesame oil may provide a moderate moisturizing effect.

[0068] Embodiment 4:

[0069] This embodiment provides a fourth burn ointment and a preparation method thereof. The burn ointment comprises the following components in weight percentage: 90% water, 1% lime, and 9% sesame oil.

[0070] The preparation method comprises the following steps:

[0071] (1) First, 90 parts by weight of water were added into a stirring container;

[0072] (2) Secondly, at a stirring speed of 400 rpm, 1 part by weight of lime was slowly added at a rate of 0.1 part by weight per minute;

[0073] (3) Then, continue stirring at 400 rpm for 30 minutes until the lime is completely dispersed;

[0074] (4) Again, maintaining a stirring speed of 400 rpm, 9 parts by weight of sesame oil was slowly added at a rate of 1.35 parts by weight per minute;

[0075] (5) Finally, stir at 400 rpm for 40 minutes until a uniform paste is formed.

[0076] In this example, the high proportion of water makes the formulation have a lower viscosity, which may be easier to spread. The very low proportion of lime may minimize potential irritation to the skin while still maintaining a slightly alkaline environment. The moderate amount of sesame oil may provide slight moisturizing and anti-inflammatory effects.

[0077] Preferably, in each embodiment of the present invention, by adjusting the ratio of water, lime and sesame oil, the alkalinity, moisture retention and fluidity of the preparation can be balanced to a certain extent. Lime and sesame oil may undergo a slight saponification reaction, which may affect the stability and viscosity of the preparation. Therefore, during the preparation process, it is crucial to slowly add the components and keep stirring well, which helps to form a uniform and stable paste.

[0078] Comparative Example 1:

[0079] This comparative example provides a burn ointment and a preparation method thereof, which are used for comparison with Example 1. The burn ointment comprises the following components in weight percentage: 60% water and 30% lime.

[0080] The preparation method comprises the following steps:

[0081] (1) First, 60 parts by weight of water were added into a stirring container;

[0082] (2) Next, 30 parts by weight of lime were slowly added at a rate of 3 parts by weight per minute at a stirring speed of 200 rpm;

[0083] (3) Then, continue stirring at 200 rpm for 35 minutes until a uniform paste is formed.

[0084] This comparative example is intended to verify the importance of sesame oil in the formulation. Compared with Example 1, this comparative example lacks the sesame oil component, which may result in the formulation lacking the necessary moisturizing and anti-inflammatory effects. In addition, due to the lack of an oil phase, the stability and spreadability of the formulation may be affected.

[0085] Comparative Example 2:

[0086] This comparative example provides another burn ointment and its preparation method, which are used for comparison with Example 2. The burn ointment comprises the following components in weight percentage: 80% water and 20% sesame oil.

[0087] The preparation method comprises the following steps:

[0088] (1) First, 80 parts by weight of water were added into a stirring container;

[0089] (2) Next, 20 parts by weight of sesame oil were slowly added at a rate of 2 parts by weight per minute at a stirring speed of 300 rpm;

[0090] (3) Finally, the mixture was stirred at 300 rpm for 52 minutes until a uniform emulsion was formed.

[0091] This comparative example is intended to verify the role of lime in the formulation. Compared with Example 2, this comparative example completely removes the lime component. Although the formulation may have good moisturizing properties, the lack of an alkaline environment may affect its potential antibacterial effect. In addition, due to the lack of the emulsifying effect of lime, the stability of the formulation may be reduced.

[0092] Comparative Example 3:

[0093] This comparative example provides a third scald ointment and a preparation method thereof, for comparison with Example 3. The scald ointment comprises the following components in weight percentage: 75% water and 25% lime.

[0094] The preparation method is the same as that of Example 3, except that the step of adding sesame oil is omitted and the final stirring time is extended to 60 minutes.

[0095] This comparative example is intended to verify the effect of lime content on the performance of the preparation. Compared with Example 3, this comparative example increases the lime content and removes sesame oil. This may cause the preparation to have too high alkalinity, increase the risk of skin irritation, and lack the necessary moisturizing effect.

[0096] Comparative Example 4:

[0097] This comparative example provides a fourth burn ointment and a preparation method thereof, which are used for comparison with Example 4. The burn ointment comprises the following components in weight percentage: 90% water, 1% lime, and 9% sesame oil.

[0098] The preparation method is exactly the same as that of Example 4.

[0099] This comparative example is intended to verify the effect of stirring speed on the performance of the formulation. Unlike Example 4, the stirring speed was reduced to 200 rpm during the entire preparation process. This may result in uneven dispersion of the components and affect the stability and uniformity of the formulation.

[0100] Comparative Example 5:

[0101] This comparative example provides a fifth scald ointment and a preparation method thereof, for comparison with Example 1. The scald ointment comprises the following components in weight percentage: 60% water, 30% lime, and 10% sesame oil.

[0102] The preparation method is the same as that of Example 1, except that the addition rates in steps (2) and (4) are increased to 6 parts by weight and 2 parts by weight per minute, respectively.

[0103] This comparative example is intended to verify the effect of the rate of component addition on the performance of the formulation. Compared with Example 1, this comparative example significantly increased the rate of addition of lime and sesame oil. This may lead to insufficient dispersion of the components, affecting the uniformity and stability of the formulation.

[0104] Comparative Example 6:

[0105] This comparative example provides a sixth scald ointment and a preparation method thereof, for comparison with Example 2. The scald ointment comprises the following components in weight percentage: 80% water, 5% lime, and 15% sesame oil.

[0106] The preparation method is the same as that of Example 2, but the stirring time of the last step is shortened to 10 minutes.

[0107] This comparative example is intended to verify the effect of stirring time on the performance of the formulation. Compared with Example 2, this comparative example significantly shortens the final stirring time. This may lead to insufficient mixing of the components, affecting the uniformity and stability of the formulation.

[0108] Through these comparative examples, the effects of the ratio of each component and the preparation parameters on the performance of the burn ointment can be systematically evaluated. These comparative experiments help to prove the synergistic effect of the components in the present invention and the importance of the parameters of each step in the preparation method. For example, comparative examples 1 and 2 respectively verify the necessity of sesame oil and lime, comparative example 3 shows the importance of the component ratio, and comparative examples 4, 5 and 6 emphasize the key role of preparation parameters (such as stirring speed, addition rate and stirring time). These comparative results may provide strong supporting evidence for the creativity of the present invention.

[0109] In order to comprehensively evaluate the performance of the burn ointment and the effectiveness of its preparation method, a series of test experiments were designed to verify the core innovation of the invention and to demonstrate the synergistic mechanism between the components.

[0110] Experiment 1: pH determination

[0111] Experimental conditions: pH was measured at 25°C using a pH meter.

[0112] Experimental method: Dissolve 1g of sample in 9mL of deionized water, stir thoroughly and measure the pH value.

[0113] Experiment 2: Viscosity measurement

[0114] Experimental conditions: using a rotational viscometer, measured at 25°C.

[0115] Experimental method: Take an appropriate amount of sample and measure the viscosity at a speed of 30 rpm.

[0116] Experiment 3: Determination of water evaporation rate

[0117] Experimental conditions: 37℃ constant temperature box.

[0118] Experimental method: Spread 2g of sample evenly in a petri dish with a diameter of 5cm, place it at 37℃ for 24 hours, and measure the weight loss.

[0119] Experiment 4: Antibacterial activity determination

[0120] Experimental conditions: sterile operating table, 37℃ constant temperature incubator.

[0121] Experimental method: The agar diffusion method was used to determine the diameter of the inhibition zone with Staphylococcus aureus as the indicator bacteria.

[0122] Experiment 5: Skin irritation determination

[0123] Experimental conditions: New Zealand white rabbits, conventionally raised.

[0124] Experimental method: Using the Draize method, apply the sample on the hair removal area on the rabbit's back and observe the skin reaction within 24 hours.

[0125] Experiment 6: Wound healing promotion test

[0126] Experimental conditions: SD rats were raised in a conventional manner.

[0127] Experimental method: A standard burn wound was created on the back of rats, samples were applied daily, and the wound healing was recorded within 7 days.

[0128] The test results are shown in the following table:

[0129]

[0130] According to the test results, Example 4 exhibits the best comprehensive performance and can be regarded as the best embodiment of the present invention. While maintaining a certain antibacterial activity, it significantly reduces skin irritation and exhibits an excellent wound healing promoting effect.

[0131] After in-depth analysis of the test data, it is found that the present invention has the following unexpected technical effects:

[0132] 1. pH regulation effect: Examples 2-4 show an interesting pH gradient, which may help to gradually regulate the wound microenvironment and promote different stages of the healing process. The formation of this pH gradient may be due to the delicate balance between lime and sesame oil, where lime provides an alkaline environment and the fatty acids in sesame oil may play a buffering role.

[0133] 2. Viscosity optimization: The viscosity range of Examples 2-4 (5000-11000 mPa·s) showed ideal spreadability and retention, which may be due to the partial saponification reaction of lime and sesame oil to form a unique colloidal structure.

[0134] 3. Moisture regulating ability: The water evaporation rate (18-25%) of Examples 2-4 is in a moderate range, which indicates that the preparation can keep the wound surface moderately moist without causing excessive infiltration. This balance may be due to the synergistic effect of the hydrophobic film formed by sesame oil and the water absorption of lime.

[0135] 4. Mild antibacterial activity: Examples 2-4 showed mild but effective antibacterial activity (inhibition zone diameter 8-15 mm), and this moderate antibacterial effect may help control wound infection without excessively inhibiting beneficial skin microbiota.

[0136] 5. Significantly reduced irritation: In particular, Example 4 has a skin irritation index of only 0.5, which is much lower than that of high-concentration lime preparations. This may be due to the complex formed by the unsaturated fatty acids in sesame oil and lime, which weakens the direct irritation of lime.

[0137] 6. Wound healing promotion effect: Examples 2-4 all showed excellent wound healing rates (70-80%), which may be due to the synergistic effect of the components in the preparation. The alkaline environment provided by the lime may help soften necrotic tissue, the fatty acids in sesame oil may participate in cell membrane repair, and the appropriate amount of water helps promote granulation tissue formation.

[0138] These unexpected technical effects fully demonstrate the potential value of the present invention in the field of burn treatment. By precisely controlling the ratio of water, lime and sesame oil and optimizing the preparation process, the present invention successfully achieves the synergistic effect of each component, while ensuring a certain therapeutic effect and significantly reducing potential side effects. The realization of this balance provides a simple and effective option for first aid treatment of burns.

[0139] The above description is only an embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A burn ointment, characterized in that , including the following components in weight percentage: Water: 60-90%, Lime: 1-30%, Sesame oil: 5-15%.

2. The burn ointment according to claim 1, characterized in that , the water content is 70-80%.

3. The burn ointment according to claim 1, characterized in that , the lime content is 5-15%.

4. The burn ointment according to claim 1, characterized in that , the content of sesame oil is 8-12%.

5. The method for preparing the burn ointment according to any one of claims 1 to 4, characterized in that , including the following steps: (1) First, add the water into a stirring container; (2) Secondly, slowly add the lime under continuous stirring; (3) Then, continue stirring until the lime is completely dispersed; (4) Again, slowly adding the sesame oil under continuous stirring; (5) Finally, stir until a uniform paste is formed.

6. The preparation method according to claim 5, characterized in that , the rate of adding lime in step (2) is no more than 10% of the total amount of lime per minute.

7. The preparation method according to claim 5, characterized in that , the stirring time in step (3) is 15-30 minutes.

8. The preparation method according to claim 5, characterized in that , the addition rate of sesame oil in step (4) is no more than 15% of the total sesame oil per minute.

9. The preparation method according to claim 5, characterized in that , the stirring time in step (5) is 20-40 minutes.

10. The preparation method according to any one of claims 5 to 9, characterized in that , the stirring speed is 200-400rpm.

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