Traditional Chinese medicine composition for restoring consciousness, soothing nerves and relieving dizziness and convulsion as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for restoring consciousness, soothing nerves and relieving dizziness and convulsion as well as a preparation method and application thereof. The traditional Chinese medicine composition for restoring consciousness, soothing the nerves and relieving dizziness and convulsion comprises the following raw materials: uncaria, feverfew, nacre mother of pearl, processed polygala tenuifolia, honey and bran fried atractylodes macrocephala, ligusticum wallichii, vine of multiflower knotweed, astragalus membranaceus, angelica sinensis, radix paeoniae rubra, fried ground beetle, herba lycopi and fried liquorice. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention has the effects of restoring consciousness, soothing the nerves, relieving dizziness and relieving convulsion, has a remarkable treatment effect on dizziness / dizziness, headache, insomnia, palpitation and the like, is definite in curative effect, and has a relatively good clinical application value.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition capable of refreshing the brain, calming the nerves, extinguishing wind and relieving convulsions, and a preparation method and use thereof. Background Art

[0002] . Stroke includes ischemic stroke and hemorrhagic stroke. Ischemic stroke accounts for about 70% of stroke in my country, while the incidence of acute posterior circulation ischemic stroke accounts for 20% of all ischemic strokes, with a mortality rate of up to 5%. Patients with acute posterior circulation ischemic stroke are mainly characterized by vertigo, accompanied by symptoms such as nausea and vomiting, limb sensory disorders, and balance behavior disorders. At the same time, the sleep time and sleep rhythm of patients with posterior circulation ischemic stroke will also change significantly, inducing symptoms such as headache, insomnia, and palpitations. For the above symptoms, Western medicine usually uses anti-vertigo, vasodilator, anti-anxiety drugs or antidepressants for symptomatic treatment, but the effect is not ideal and is prone to relapse, causing great distress to patients. Therefore, it is very necessary to develop a drug that can solve the above problems. Summary of the invention

[0003] In order to overcome the problems existing in the prior art, the purpose of the present invention is to provide a Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming convulsions, and a preparation method and use thereof.

[0004] In order to achieve the above-mentioned purpose and other related purposes, the present invention adopts the following technical solutions:

[0005] The first aspect of the present invention provides a Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming the convulsions, comprising the following component raw materials in the following weight proportions: 10-20 parts of Uncaria rhynchophylla, 5-15 parts of white chrysanthemum, 20-40 parts of mother-of-pearl, 5-15 parts of processed Polygala tenuifolia, 5-15 parts of stir-fried Atractylodes macrocephala with honey bran, 3-9 parts of Chuanxiong, 10-20 parts of Polygonum multiflorum, 10-20 parts of Astragalus membranaceus, 5-15 parts of Angelica sinensis, 5-15 parts of red peony root, 5-15 parts of stir-fried Eupolyphaga sinensis, 5-15 parts of Zedoariae rhizome and 1-5 parts of stir-fried Licorice root.

[0006] In one embodiment, the weight ratio of the raw materials of each component is: 15 parts of Uncaria rhynchophylla, 10 parts of white chrysanthemum, 30 parts of mother of pearl, 10 parts of processed Polygala tenuifolia, 10 parts of stir-fried Atractylodes macrocephala with honey bran, 6 parts of Ligusticum chuanxiong, 15 parts of Polygonum multiflorum, 15 parts of Astragalus membranaceus, 10 parts of Angelica sinensis, 10 parts of red peony root, 10 parts of stir-fried Eupolyphaga sinensis, 10 parts of Zedoariae rhizome and 3 parts of stir-fried licorice.

[0007] The second aspect of the present invention provides a method for preparing the aforementioned Chinese medicine composition, wherein the preparation method is a water extraction method.

[0008] In one embodiment, the preparation method is: taking each component raw material, soaking it in water, decocting it, filtering it, adding an appropriate amount of water to the medicinal material, decocting it again, filtering it, and combining the two filtrates to obtain the product.

[0009] In one embodiment, the soaking time is 0.5 to 2 hours.

[0010] In one embodiment, the decoction time is 30 to 50 minutes; the re-decoction time is 20 to 40 minutes.

[0011] The third aspect of the present invention provides the use of the aforementioned Chinese medicine composition in the preparation of a medicine for treating dizziness / vertigo, headache, insomnia, and palpitations.

[0012] In one embodiment, the dizziness / vertigo, headache, insomnia, and palpitations are induced by posterior circulation ischemia. Posterior circulation ischemia is a common ischemic cerebrovascular disease involving the vertebral basilar artery system, which is composed of the vertebral artery, basilar artery and posterior cerebral artery, and mainly supplies blood to the brainstem, cerebellum, thalamus, hippocampus, occipital lobe, part of the temporal lobe and spinal cord. The causes of posterior circulation ischemia are mainly atherosclerosis, cardiogenic embolism, vertebral-basilar artery extension, etc., and advanced age, unhealthy lifestyle, hyperlipidemia, hyperglycemia, history of stroke, etc. are all risk factors for posterior circulation ischemia. In one embodiment, the dizziness / vertigo, headache, insomnia, and palpitations are induced by posterior circulation ischemic stroke. The posterior circulation ischemic stroke refers to transient ischemic attack and cerebral infarction of the carotid artery system of the posterior circulation.

[0013] The fourth aspect of the present invention provides a Chinese medicine preparation, comprising the aforementioned Chinese medicine composition. The Chinese medicine preparation comprises a therapeutically effective amount of the aforementioned Chinese medicine composition. The Chinese medicine preparation further comprises one or more conventional pharmaceutically acceptable excipients.

[0014] Wherein, pharmaceutically acceptable adjuvant includes but is not limited to pharmaceutically acceptable carrier, diluent, filler, bonding agent and other excipient. The inorganic or organic carrier of the treatment inertia known to the art personnel in this area includes but is not limited to lactose, corn starch or its derivatives, talcum, vegetable oil, wax, fat, polyol such as polyethylene glycol, water, sucrose, ethanol, glycerine, and the like, various preservatives, lubricants, dispersants, flavoring agents. Wetting agent, antioxidant, sweetener, coloring agent, stabilizer, salt, buffer and the like can also be added thereto, and these materials are used to help the stability of the formula as required or help to improve the activity or its biological effectiveness or produce acceptable mouthfeel or smell in the case of oral administration. Chinese medicine preparations such as granules and ointments can be prepared by conventional methods. Pharmaceutical composition of the present invention can also be used together with other therapeutic agents.

[0015] In one embodiment, the Chinese medicine preparation is an oral preparation, including but not limited to solutions, granules, pills, tablets, capsules, syrups, and sprays.

[0016] After the effective ingredients in the traditional Chinese medicine composition are extracted, conventional pharmaceutical excipients and additives can be used to prepare the aforementioned traditional Chinese medicine preparation.

[0017] The Chinese medicinal materials used in the embodiments of the present invention are all Chinese medicinal materials included in the 2020 edition of the Chinese Pharmacopoeia and meet the quality requirements of the Pharmacopoeia. Specifically, the nature, flavor, meridians and functions of the Chinese medicinal raw materials are as follows:

[0018] (1) Uncaria rhynchophylla:

[0019] Nature and flavor: sweet, cool. Enters the liver and pericardium meridians. Functions and indications: clears away heat and calms the liver, calms the wind and calms the nerves. Used for headache and dizziness, colds with convulsions, convulsions, eclampsia during pregnancy, and hypertension.

[0020] (2) White Chrysanthemum

[0021] Nature and flavor: bitter, sweet, slightly cold. Enters the lung and liver meridians. Functions and indications: dispel wind and heat, soothe the liver and improve eyesight, detoxify and reduce swelling. Used for exogenous wind-heat, fever, aversion to cold, headache, red and swollen eyes, swollen and painful sores, dizziness, vertigo, head swelling, headache caused by hyperactivity of liver yang.

[0022] (3) Mother of pearl

[0023] Nature and flavor: salty, cold. Enters the liver and heart meridians. Functions and indications: soothes the liver and suppresses yang, calms the mind and calms the nerves, and removes cataracts. Used for headache, dizziness, palpitations, insomnia, red eyes, cataracts, and blurred vision.

[0024] (4) Polygala tenuifolia

[0025] Nature and flavor: bitter, pungent, warm. Enters the heart, kidney and lung meridians.

[0026] Functions and indications: calms the mind, improves intelligence, removes phlegm, and reduces swelling. It is used for insomnia, dreaminess, forgetfulness, palpitations, confusion, coughing up phlegm, sores, swelling and pain in the breasts caused by disharmony between the heart and kidney.

[0027] Prepare Polygala: Take licorice, add appropriate amount of water to boil, remove the residue, add clean Polygala, simmer until the soup is absorbed, take out and dry. For every 100kg of Polygala, use 6kg of licorice.

[0028] (5) Atractylodes macrocephala

[0029] Nature and flavor: bitter, sweet, warm. Enters the spleen and stomach meridians.

[0030] Functions and indications: Strengthen the spleen and replenish qi, dry dampness and promote diuresis, stop sweating, and stabilize the fetus. Used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and restless fetus.

[0031] Stir-fried Atractylodes macrocephala with honey bran: Sprinkle the honey bran into the hot pot, add the Atractylodes macrocephala slices when it smokes, and stir-fry until brown and emits a burnt aroma. Take it out and sieve out the honey bran. For every 100kg of Atractylodes macrocephala slices, use 10kg of honey bran. Stir-fried honey bran is good for nourishing blood and liver, and is good for relieving pain.

[0032] (6) Chuanxiong

[0033] Nature and flavor: pungent, warm. Enters the liver, gallbladder, and heart meridians. Functions and indications: promotes blood circulation and qi, dispels wind and relieves pain. Used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to abdominal masses, stabbing pain in the chest and ribs, swelling and pain due to falls, headache, and rheumatic pain.

[0034] (7) Polygonum multiflorum

[0035] Nature and flavor: sweet, neutral. Enters the heart and liver meridians. Functions and indications: nourishes blood and calms the mind, dispels wind and dredges the meridians. Used for insomnia, body pain due to blood deficiency, rheumatic pain; external treatment for skin itching.

[0036] (8) Astragalus

[0037] Nature and flavor: sweet, warm. Enters the lung and spleen meridians.

[0038] Functions and indications: replenishing qi and strengthening the exterior, promoting diuresis and expelling toxins, draining pus, healing sores and promoting tissue regeneration. Used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, carbuncle that is difficult to heal, long-term ulcers that do not heal, blood deficiency and jaundice, internal heat and thirst; proteinuria due to chronic nephritis, and diabetes.

[0039] (9) Angelica

[0040] Nature and flavor: sweet, pungent, warm. Enters the liver, heart and spleen meridians.

[0041] Functions and indications: nourishing blood and activating blood circulation, regulating menstruation and relieving pain, moistening intestines and relieving constipation. Used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dry intestines, rheumatic arthralgia, injuries from falls, carbuncle and ulcer. Wine Angelica activates blood circulation and regulates menstruation. Used for amenorrhea and dysmenorrhea, rheumatic arthralgia, injuries from falls.

[0042] (10) Red Peony Root

[0043] Nature and flavor: bitter, slightly cold. Enters the liver meridian. Functions and indications: clears heat and cools blood, dissipates blood stasis and relieves pain. Used for fever and rashes, vomiting blood and bleeding, red and swollen eyes, liver depression and flank pain, amenorrhea and dysmenorrhea, abdominal pain due to abdominal masses, injuries from falls, carbuncles, swellings and ulcers.

[0044] (11) Earthworm

[0045] Nature and flavor: salty, cold; slightly toxic. Enters the liver meridian. Functions and indications: promote blood circulation and remove blood stasis, reduce swelling and relieve pain, and fix bones and tendons. Used for tendon and bone fractures, blood stasis, amenorrhea, and lumps.

[0046] Stir-fried earthworms: Stir-fry over low heat until slightly charred.

[0047] (12) Zeeland

[0048] Nature and flavor: bitter, pungent, slightly warm. Enters the liver and spleen meridians. Functions and indications: promote blood circulation and remove blood stasis, promote water circulation and reduce swelling. Used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain caused by blood stasis after childbirth, and edema.

[0049] Stir-fried earthworms: Stir-fry over low heat until slightly charred.

[0050] (13) Licorice

[0051] Nature and flavor: sweet, neutral. Enters the heart, lung, spleen, and stomach meridians. Functions and indications: tonifies the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines. Used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, cramps and pain in the abdomen and limbs, carbuncle, sore, and relieves drug toxicity and potency.

[0052] Stir-fry licorice: Put the processed licorice slices into the stir-frying container and stir-fry over a low heat. Stir constantly during the stir-frying process until the color of the licorice slices changes from yellow to dark yellow and they are no longer sticky, then take them out.

[0053] The prescription of the present invention uses Uncaria rhynchophylla and white chrysanthemum as the main drugs, which can clear away heat and cool the liver, extinguish wind and calm the nerves; pearl mother, processed Polygala tenuifolia, stir-fried Atractylodes macrocephala with honey bran, Chuanxiong, and Polygonum multiflorum as the assistant drugs, which can calm the mind and soothe the nerves, clear liver fire, and nourish liver yin; astragalus, angelica, red peony root, stir-fried Eupolyphaga sinensis, and Zedoariae rhizome as the adjuvant drugs, which can replenish qi, nourish blood, and promote blood circulation; stir-fried liquorice is the guiding drug, which can harmonize the drugs; the drugs are used together, which can wake up the brain and calm the nerves, extinguish wind and calm the nerves. Clinical application data show that the prescription of the present invention has a good therapeutic effect on symptoms such as dizziness / vertigo, headache, insomnia, palpitations, etc. induced by posterior circulation ischemia, especially dizziness / vertigo, headache, insomnia, palpitations, etc. induced by acute posterior circulation ischemic stroke.

[0054] Compared with the prior art, the present invention has the following beneficial effects:

[0055] 1. The Chinese medicine composition provided by the present invention has natural raw materials with wide sources, simple preparation method, does not contain organic solvents, is safe and reliable, has low cost, and has synergistic effects among the components to achieve the effects of refreshing the brain, calming the nerves, and extinguishing wind and calming the nerves.

[0056] 2. The Chinese medicine composition provided by the present invention has a definite therapeutic effect on dizziness / vertigo, headache, insomnia, palpitations, etc. induced by posterior circulation ischemia, and has good clinical application value. DETAILED DESCRIPTION

[0057] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are intended to describe specific embodiments, rather than to limit the scope of protection of the present invention. The test methods in the following examples without specifying specific conditions are generally carried out under conventional conditions or under conditions recommended by the manufacturers.

[0058] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the grasp of the prior art by those skilled in the art and the record of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to realize the present invention.

[0059] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in the technical field.

[0060] Example 1

[0061] A Chinese medicinal composition for refreshing the brain, calming the nerves, extinguishing wind and calming convulsions comprises the following component raw materials in the following weight proportions: 10 parts of Uncaria rhynchophylla, 5 parts of white chrysanthemum, 20 parts of mother-of-pearl, 5 parts of processed Polygala tenuifolia, 5 parts of stir-fried Atractylodes macrocephala with honey bran, 3 parts of Ligusticum chuanxiong, 10 parts of Polygonum multiflorum, 10 parts of Astragalus membranaceus, 5 parts of Angelica sinensis, 5 parts of red peony root, 5 parts of stir-fried Eupolyphaga sinensis, 5 parts of Zedoariae rhizome and 1 part of stir-fried Licorice root.

[0062] A method for preparing a Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming the nerves comprises the following steps: adding 8 times the amount of water to 10g of Uncaria rhynchophylla, 5g of white chrysanthemum, 20g of mother-of-pearl, 5g of processed Polygala tenuifolia, 5g of stir-fried Atractylodes macrocephala with honey bran, 3g of Chuanxiong, 10g of Polygonum multiflorum, 10g of Astragalus, 5g of Angelica sinensis, 5g of Red Peony Root, 5g of stir-fried Eupolyphaga sinensis, 5g of Eupatorium fortunei and 1g of stir-fried Licorice, soaking for 1h, decocting for 40min, filtering, adding 6 times the amount of water to the residues, repeating the decocting for 30min, filtering, and combining the two filtrates to obtain the composition.

[0063] Example 2

[0064] A Chinese medicinal composition for refreshing the brain, calming the nerves, extinguishing wind and calming convulsions comprises the following raw materials in the following weight proportions: 15 parts of Uncaria rhynchophylla, 10 parts of white chrysanthemum, 30 parts of mother-of-pearl, 10 parts of processed Polygala tenuifolia, 10 parts of stir-fried Atractylodes macrocephala with honey bran, 6 parts of Ligusticum chuanxiong, 15 parts of Polygonum multiflorum, 15 parts of Astragalus membranaceus, 10 parts of Angelica sinensis, 10 parts of red peony root, 10 parts of stir-fried Eupolyphaga sinensis, 10 parts of Zedoariae rhizome and 3 parts of stir-fried Licorice root.

[0065] A method for preparing a Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming the nerves comprises the following steps: adding 8 times the amount of water to 15g of Uncaria rhynchophylla, 10g of white chrysanthemum, 30g of mother-of-pearl, 10g of processed Polygala tenuifolia, 10g of stir-fried Atractylodes macrocephala with honey bran, 6g of Chuanxiong, 15g of Polygonum multiflorum, 15g of Astragalus, 10g of Angelica sinensis, 10g of red peony root, 10g of stir-fried Eupolyphaga sinensis, 10g of Eupatorium fortunei and 3g of stir-fried Licorice, soaking for 1h, decocting for 40min, filtering, adding 6 times the amount of water to the residues, repeating the decocting for 30min, filtering, and combining the two filtrates to obtain the composition.

[0066] Example 3

[0067] A Chinese medicinal composition for refreshing the brain, calming the nerves, extinguishing wind and calming convulsions comprises the following raw materials in the following weight proportions: 20 parts of Uncaria rhynchophylla, 15 parts of white chrysanthemum, 40 parts of mother-of-pearl, 15 parts of processed Polygala tenuifolia, 15 parts of stir-fried Atractylodes macrocephala with honey bran, 9 parts of Ligusticum chuanxiong, 20 parts of Polygonum multiflorum, 20 parts of Astragalus membranaceus, 15 parts of Angelica sinensis, 15 parts of red peony root, 15 parts of stir-fried Eupolyphaga sinensis, 15 parts of Zedoariae rhizome and 5 parts of stir-fried Licorice root.

[0068] A preparation method of a Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming the nerves comprises the following steps: adding 8 times the amount of water to 20g of Uncaria rhynchophylla, 15g of white chrysanthemum, 40g of mother-of-pearl, 15g of processed Polygala tenuifolia, 15g of stir-fried Atractylodes macrocephala with honey bran, 9g of Ligusticum chuanxiong, 20g of Polygonum multiflorum, 20g of Astragalus, 15g of Angelica sinensis, 15g of red peony root, 15g of stir-fried Eupolyphaga sinensis, 15g of Eupatorium fortunei and 5g of stir-fried Licorice, soaking for 1h, decocting for 40min, filtering, adding 6 times the amount of water to the residues, repeating the decocting for 30min, filtering, and combining the two filtrates to obtain the composition.

[0069] Clinical Data

[0070] Case source: The subjects were 30 patients who visited Shanghai Seventh People's Hospital and were diagnosed with dizziness / vertigo between January 2022 and December 2024. The age range was 18-75 years old and they were randomly divided into two groups. One group was treated with the Chinese medicine composition of the present invention combined with betahistine mesylate tablets (6 mg / time, 3 times / d) for one course of treatment, with a total of 15 cases; the other group only used betahistine mesylate tablets (6 mg / time, 3 times / d), with a total of 15 cases.

[0071] 1. Diagnostic criteria

[0072] According to the "Guidelines for Primary Diagnosis and Treatment of Dizziness / Vertigo (2019)", the diagnostic criteria for dizziness / vertigo.

[0073] 2. Experimental methods and observation indicators

[0074] The Chinese medicine treatment group (Chinese medicine composition + betahistine mesylate tablets) was given the Chinese medicine composition decoction of Example 2 of the present invention, with a dosage of 400 ml, one dose per day, one dose taken in 2 times, and combined with betahistine mesylate tablets (6 mg / time, 3 times / d); the treatment was continued for 7 days.

[0075] The control group (betahistine mesylate tablets) was only given betahistine mesylate tablets (6 mg / time, 3 times / day) for 7 days.

[0076] 3. Efficacy determination

[0077] (1) Cured: Dizziness / vertigo and other accompanying symptoms disappear;

[0078] (2) Significant effect: Dizziness / vertigo and other accompanying symptoms are significantly alleviated, with a slight dizziness or light-headedness, but without a sense of rotation of oneself or the scenery; the patient can live and work normally;

[0079] (3) Effective: dizziness / vertigo and other accompanying symptoms are alleviated, and vertigo is accompanied by a slight sense of rotation of oneself and the scenery. Although work can be continued, life and work are affected;

[0080] (4) Ineffective: Symptoms such as dizziness / vertigo did not improve or worsened.

[0081] 4. Results

[0082] The results are shown in Table 1 below:

[0083] Table 1 Comparison of the efficacy of the two groups after drug treatment

[0084]

[0085] As shown in Table 1, among the 15 patients with dizziness / vertigo who used betahistine mesylate tablets alone in the control group, 10 were cured, 3 were markedly effective, 1 was effective, and 1 was ineffective, with a cure rate of 66.67% and a total effective rate of 93.33%; among the 15 patients in the Chinese medicine treatment group combined with the Chinese medicine composition of the present invention, 12 were cured, 2 were markedly effective, 1 was effective, and 0 was ineffective, with a cure rate of 80% and a total effective rate of 100%. The results showed that the total cure rate of the Chinese medicine treatment group increased by 19.99% compared with the control group, and the effective rate increased by 7.15%, and the effect of improving dizziness / vertigo was better than that of the control group.

[0086] Typical Case 1

[0087] Lu, female, Shanghai Seventh People's Hospital, hospital number: 606***

[0088] The patient was admitted to the hospital due to "dizziness for more than 10 days". The patient had dizziness and visual rotation without obvious cause 10 days before admission, accompanied by nausea and vomiting. The dizziness was obviously related to body position, and the symptoms recurred. He had a history of cerebral infarction for more than 3 years and had sleep disorders in the past 2 months. For further treatment, he was admitted to the hospital for "posterior circulation ischemia". At present: the patient is in general spirit, dizzy, only appetite is OK, sleep is restless at night, and bowel movements are normal.

[0089] TCM diagnosis: vertigo, qi and blood deficiency syndrome

[0090] Western medicine diagnosis: 1. Posterior circulation ischemia 2. Personal history of cerebral infarction

[0091] The patient was dizzy and had poor sleep recently, with pale and tender tongue, thin white tongue coating and thin pulse. The four examinations were combined, and the disease was diagnosed as "vertigo" and "insomnia" in traditional Chinese medicine, and the syndrome was diagnosed as qi and blood deficiency syndrome, which was treated with nourishing the liver and kidney, nourishing the heart and strengthening the spleen. The decoction obtained in Example 2 of the present invention was given to wake up the brain and calm the mind, extinguish wind and calm the nerves, one dose a day, one dose of 400ml (took twice), and continued for 7 days. The patient's dizziness and sleep improved, and the patient was discharged after the condition stabilized.

[0092] Typical Case 2

[0093] Gu, male, Shanghai Seventh People's Hospital, hospital number: 628***

[0094] The patient was admitted to the hospital due to "dizziness for 1 week". On the morning of August 22, 2023, he had dizziness, drowsiness and discomfort without obvious cause, accompanied by swelling of the head, pain in the back of the head, and general fatigue and discomfort. The dizziness is not related to changes in body position. He has a history of hypertension for more than 10 years and a history of sleep disorders for many years. For further treatment, the outpatient department plans to admit him to the hospital for "posterior circulation ischemia". At present: the patient is dizzy, has difficulty falling asleep, is in good spirits, has a good appetite, and has normal urination and defecation.

[0095] TCM diagnosis: vertigo, qi and blood deficiency syndrome

[0096] Western medicine diagnosis: 1. Posterior circulation ischemia 2. Hypertension stage 3 (extremely high risk) 3. Sleep disorder 4. Coronary artery atherosclerosis

[0097] The patient's tongue was pale and tender, with a thin white tongue coating and a thready pulse. The four examinations were combined, and the disease was diagnosed as "vertigo" in traditional Chinese medicine, and the syndrome was diagnosed as qi and blood deficiency syndrome, which was treated with nourishing qi and blood, extinguishing wind and calming the nerves, and nourishing the heart and strengthening the spleen. The decoction obtained in Example 2 of the present invention was given to wake up the brain and calm the nerves, extinguish wind and calm the nerves, one dose a day, one dose of 400ml (took twice), for 7 days, the patient's dizziness gradually eased, and he went home to continue taking it for consolidation treatment after being discharged from the hospital.

[0098] Typical Case 3

[0099] Sha, female, Shanghai Seventh People's Hospital, hospital number: 612***

[0100] The patient was admitted to the hospital due to "dizziness for 1 week". The patient had dizziness without obvious cause 1 week before admission. He denied visual rotation, nausea and vomiting, and had no difficulty in limb movement, blurred vision, double vision, and repeated symptoms. He could be relieved after rest. In order to further clarify the diagnosis, he was admitted to the hospital for "vertigo". At present: the patient is in general spirit, dizzy, with good appetite, good sleep at night, and normal bowel movements.

[0101] TCM diagnosis: vertigo, qi and blood deficiency syndrome

[0102] Western medicine diagnosis: 1. Posterior circulation ischemia 2. Hypertension stage 3 (extremely high risk) 3. Coronary artery atherosclerosis

[0103] The patient's tongue was pale and tender, with a thin white tongue coating and a thready pulse. The four examinations were combined, and the disease was diagnosed as "vertigo" in traditional Chinese medicine, and the syndrome was diagnosed as qi and blood deficiency syndrome, which was treated with nourishing qi and blood, extinguishing wind and calming the nerves, nourishing the heart and strengthening the spleen, and the decoction obtained in Example 2 of the present invention was given to wake up the brain and calm the nerves, extinguish wind and calm the nerves, one dose a day, one dose of 400ml (took twice), and continued for 7 days, and the patient's dizziness gradually improved.

[0104] From the above clinical application results, it can be seen that the Chinese medicine composition provided by the present invention has the effects of refreshing the brain and calming the nerves, calming the wind and relieving spasms, and has a good therapeutic effect on dizziness, insomnia and the like induced by posterior circulation ischemia.

[0105] The above is only a preferred embodiment of the present invention, and is not any formal or substantial limitation of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present invention, and these improvements and supplements should also be regarded as the protection scope of the present invention. Any technician familiar with this profession, without departing from the spirit and scope of the present invention, can make some changes, modifications and evolutions of the technical content disclosed above, which are equivalent embodiments of the present invention; at the same time, any changes, modifications and evolutions of any equivalent changes made to the above embodiments based on the essential technology of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for refreshing the brain, calming the nerves, extinguishing wind and calming convulsions, characterized in that: The invention comprises the following raw materials in proportion by weight: 10-20 parts of Uncaria rhynchophylla, 5-15 parts of white chrysanthemum, 20-40 parts of mother-of-pearl, 5-15 parts of processed Polygala tenuifolia, 5-15 parts of stir-fried Atractylodes macrocephala with honey bran, 3-9 parts of Ligusticum chuanxiong, 10-20 parts of Polygonum multiflorum, 10-20 parts of Astragalus membranaceus, 5-15 parts of Angelica sinensis, 5-15 parts of Red Peony Root, 5-15 parts of stir-fried Eupolyphaga sinensis, 5-15 parts of stir-fried Eupolyphaga sinensis, and 1-5 parts of stir-fried Licorice root.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in proportion by weight: 15 parts of Uncaria rhynchophylla, 10 parts of white chrysanthemum, 30 parts of mother-of-pearl, 10 parts of processed Polygala tenuifolia, 10 parts of stir-fried Atractylodes macrocephala with honey bran, 6 parts of Ligusticum chuanxiong, 15 parts of Polygonum multiflorum, 15 parts of Astragalus membranaceus, 10 parts of Angelica sinensis, 10 parts of red peony root, 10 parts of stir-fried Eupolyphaga sinensis, 10 parts of Zedoariae rhizome and 3 parts of stir-fried Licorice root.

3. A method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The preparation method is a water extraction method.

4. The preparation method according to claim 3, characterized in that: The preparation method comprises the following steps: taking raw materials of various components, soaking them in water, boiling them, filtering them, adding appropriate amount of water to the medicinal materials, boiling them again, filtering them, and combining the two filtrates to obtain the medicinal material.

5. The preparation method according to claim 4, characterized in that: Also includes one or more of the following features: (a) the soaking time is 0.5 to 2 hours; (b) The decoction time is 30 to 50 minutes; the re-decoction time is 20 to 40 minutes.

6. Use of the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 3 to 5 in the preparation of drugs for treating dizziness / vertigo, headache, insomnia, and palpitations.

7. The use according to claim 6, characterized in that The dizziness / vertigo, headache, insomnia and palpitations are induced by posterior circulation ischemia.

8. A Chinese medicine preparation, comprising the Chinese medicine composition according to claim 1 or 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 3 to 5.

9. The Chinese medicine preparation according to claim 7, characterized in that: The Chinese medicine preparation is an oral preparation, including solution, granules, pills, tablets, capsules, syrups and sprays.

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