Traditional Chinese medicine composition for relieving hypertension symptoms and preparation method, traditional Chinese medicine preparation and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving hypertension symptoms and a preparation method, a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of centella asiatica, 5-15 parts of ginkgo, 5-15 parts of salvia miltiorrhiza, 15-25 parts of radix puerariae, 5-15 parts of eucommia ulmoides, 10-20 parts of fenugreek, 5-15 parts of cortex lycii radicis and 5-15 parts of liquorice. In-vivo and in-vitro tests show that the traditional Chinese medicine composition provided by the invention is scientific and reasonable in proportioning, has the effects of promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals, clearing heat and promoting diuresis, and enriching yin and nourishing kidney, can regulate and control a plurality of target spots of hypertension, regulates abnormal systolic pressure and diastolic pressure caused by hypertension, and plays a role in relieving hypertension symptoms.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for relieving hypertension symptoms, a preparation method thereof, a traditional Chinese medicine preparation and application thereof. Background Art

[0002] Hypertension is one of the most common chronic diseases worldwide and poses a serious threat to human health. It is not only an important risk factor for cardiovascular and cerebrovascular diseases, but is also closely related to a variety of diseases such as myocardial infarction, heart failure, stroke, chronic kidney disease, etc. The long-term presence of hypertension can cause damage to important target organs such as the heart, brain, and kidneys, seriously affecting the patient's quality of life and life expectancy. For example, the risk of stroke in hypertensive patients is 3-4 times that of people with normal blood pressure, and the risk of heart failure increases by 2-3 times. In addition, hypertension is also interrelated with diseases such as metabolic syndrome and diabetes, further increasing the health burden of patients.

[0003] At present, the etiology of hypertension is still a medical problem. The pathogenesis of hypertension is complex and involves multiple factors. Genetic factors play an important role in the onset of hypertension, and family history is one of the independent risk factors for the onset of hypertension. In addition, environmental factors such as high-salt diet, obesity, long-term mental stress, smoking, and drinking are also closely related to the occurrence of hypertension. From the perspective of pathophysiological mechanisms, hypertension is mainly related to factors such as activation of the renin-angiotensin-aldosterone system (RAAS), overexcitement of the sympathetic nervous system, endothelial dysfunction, and insulin resistance. At present, the main methods for clinical treatment of hypertension include lifestyle intervention and drug therapy. Lifestyle intervention includes weight control, restriction of salt and alcohol intake, and increased exercise, but it is difficult to effectively control blood pressure by lifestyle intervention alone. In terms of drug treatment, commonly used antihypertensive drugs include angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor antagonists (ARB), calcium channel blockers (CCB), diuretics, etc. However, these drugs have certain limitations in the treatment process, such as poor tolerance of some patients to drugs, low compliance with long-term medication, and possible side effects. In addition, for patients with refractory hypertension, the effects of existing drug treatments are still unsatisfactory.

[0004] Traditional medicine and traditional Chinese medicine have unique advantages in treating complex chronic diseases such as hypertension. Traditional Chinese medicine emphasizes the overall concept and syndrome differentiation and treatment, and fundamentally improves the patient's physique and symptoms by regulating the balance of yin and yang and the circulation of qi and blood in the human body. For example, traditional Chinese medicine believes that the pathogenesis of hypertension is mostly liver and kidney yin deficiency, liver yang hyperactivity, phlegm and dampness obstruction, etc., and through the treatment of calming the liver and suppressing yang, clearing heat and purging fire, promoting blood circulation and removing blood stasis, it can effectively lower blood pressure and improve the patient's dizziness, headache, insomnia and other symptoms. Modern pharmacological studies have shown that many Chinese medicines have the effects of lowering blood pressure, improving vascular endothelial function, and protecting the heart and kidneys. Compared with Western medicine, Chinese medicine has less toxic and side effects, and can achieve synergistic synergy through compound compatibility, reducing the dosage of a single drug. In the previous study, the inventor team found through the knowledge graph technology in the field of artificial intelligence and network pharmacology technology that compound Chinese medicine preparations belong to a kind of drug combination, which can simultaneously target multiple targets of the disease network and coordinate regulation, can reduce toxicity and increase efficacy, and is more suitable for the treatment of chronic diseases such as hypertension.

[0005] The inventor team has discovered a new type of Chinese medicine composition in the study of hypertension and combined with clinical practice. The dosage is small and the ratio is scientific and reasonable. It can effectively relieve the symptoms related to hypertension, and can effectively regulate the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the hypertensive animal model. It has less toxic side effects and better safety. The Chinese medicine composition of the present invention is expected to provide a low-toxic and efficient treatment method for the clinical treatment of hypertension. Summary of the invention

[0006] The purpose of the present invention is to solve the deficiencies of the prior art and provide a Chinese medicine composition for relieving hypertension symptoms and a preparation method, a Chinese medicine preparation and application thereof.

[0007] Specifically, the present invention is realized through the following technical solutions:

[0008] In the first aspect, the present invention provides a traditional Chinese medicine composition for relieving symptoms of hypertension, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 5-15 parts of Centella asiatica, 5-15 parts of Ginkgo biloba, 5-15 parts of Salvia miltiorrhiza, 15-25 parts of Pueraria lobata, 5-15 parts of Eucommia ulmoides, 10-20 parts of Fenugreek, 5-15 parts of Lycium bark, and 5-15 parts of Licorice.

[0009] As an optional manner, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made of the following traditional Chinese medicine raw materials in parts by weight: 8-12 parts of Centella asiatica, 5-10 parts of Ginkgo biloba, 8-12 parts of Salvia miltiorrhiza, 20-25 parts of Pueraria lobata, 5-10 parts of Eucommia ulmoides, 10-20 parts of Fenugreek, 8-12 parts of Lycium bark, and 5-10 parts of Licorice.

[0010] As an optional manner, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made of the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Centella asiatica, 8 parts of Ginkgo biloba, 10 parts of Salvia miltiorrhiza, 25 parts of Pueraria lobata, 8 parts of Eucommia ulmoides, 15 parts of Fenugreek, 10 parts of Lycium bark, and 8 parts of Licorice.

[0011] In a second aspect, the present invention provides a method for preparing the Chinese medicine composition for relieving hypertension symptoms described in the first aspect, wherein the preparation method is selected from any one of the following:

[0012] A: Add 5-12 times the amount of water to the Chinese medicinal raw materials in the prescription, decoct together, filter, and concentrate the filtrate;

[0013] B: Add 50-90% ethanol aqueous solution to the Chinese medicinal raw materials in the prescription amount for reflux extraction, filter, and concentrate the filtrate;

[0014] C: Add 5-12 times the amount of water to the Chinese medicinal raw materials in the prescription and decoct them, then filter; add 50-90% ethanol aqueous solution to the medicinal residues for reflux extraction, filter, and combine the filtrates for concentration.

[0015] As an optional manner, in the above-mentioned preparation method, in the above-mentioned method A, method B or method C, water is added and decocted for 1-3 times, and each extraction is 1-12 hours, preferably 2-4 hours; the amount of ethanol aqueous solution used in the ethanol aqueous solution reflux extraction operation is 8-10 times the weight of the medicinal material, and each extraction is 1-12 hours, preferably 2-4 hours.

[0016] In the third aspect, the present invention provides a traditional Chinese medicine preparation for relieving the symptoms of hypertension, wherein the traditional Chinese medicine preparation comprises the traditional Chinese medicine composition described in the first aspect above or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect above, and a pharmaceutically acceptable carrier and / or excipient.

[0017] As an optional method, in the above-mentioned traditional Chinese medicine preparation, the pharmaceutically acceptable carrier and / or excipient is selected from one or more of liposomes, microcrystalline cellulose, sodium carboxymethyl starch, sodium carboxymethyl cellulose, polyethylene glycol, polyvinyl alcohol, acrylic polymers, glycerol, propylene glycol, sorbitol, β-cyclodextrin, Tween-80, lactose, starch, Euqite S-100, Euqite L-100, sodium alginate, pectin, and dextrin.

[0018] As an optional mode, in the above-mentioned traditional Chinese medicine preparation, the traditional Chinese medicine preparation is granules, capsules, oral liquids, tablets, pills, pellets, ointments, decoctions, injections or microcapsules.

[0019] In the fourth aspect, the present invention provides the use of the Chinese medicine composition described in the first aspect above, or the Chinese medicine composition prepared by the preparation method described in the second aspect above, or the Chinese medicine preparation described in the third aspect above in the preparation of a drug for relieving the symptoms of hypertension.

[0020] In the Chinese medicine composition for relieving hypertension symptoms provided by the present invention:

[0021] Centella asiatica is cold in nature and bitter in taste. It enters the liver, spleen, and kidney meridians. It has the effects of clearing heat and dampness, detoxifying and reducing swelling.

[0022] Ginkgo is mild in nature, sweet and astringent in taste, and enters the lung and kidney meridians. It has the effects of astringing the lungs and relieving asthma, stopping leukorrhea and reducing urination.

[0023] Salvia miltiorrhiza is slightly cold and bitter in nature. It enters the heart and liver meridians. It has the effects of promoting blood circulation, removing blood stasis, regulating menstruation and relieving pain.

[0024] Pueraria root is cool in nature and sweet in taste. It enters the stomach, lung and spleen meridians. It has the effects of relieving muscles and reducing fever, and promoting blood circulation and activating collaterals.

[0025] Eucommia ulmoides is warm in nature and sweet in taste. It enters the liver and kidney meridians and has the effects of nourishing yin and kidney, strengthening tendons and bones.

[0026] Fenugreek is warm in nature and bitter in taste. It enters the kidney and bladder meridians. It has the effects of warming the kidney and assisting yang, dispelling cold and dampness.

[0027] Rehmannia root bark is cold in nature and sweet in taste. It enters the lung, liver, and kidney meridians. It has the effects of clearing heat and cooling blood, and relieving deficiency fever.

[0028] Licorice is warm in nature and sweet in taste. It enters the heart, lung, stomach and spleen meridians and has the effects of tonifying the spleen and stomach, replenishing qi and restoring pulse. It can harmonize various medicines and reduce the toxic side effects of drugs.

[0029] The above drugs are used together, based on the theory of "monarch, minister, assistant and messenger" in traditional Chinese medicine, and are reasonably configured and mutually compatible. In the present invention, Pueraria root is used as the monarch drug for promoting blood circulation and activating collaterals, relieving muscles and promoting body fluid; Eucommia bark, Salvia miltiorrhiza, and Ginkgo biloba are used as ministerial drugs for nourishing yin and tonifying the kidney, promoting blood circulation and removing blood stasis, and restraining the lungs and relieving asthma; Centella asiatica and Rehmannia root bark are used as adjuvant drugs for clearing heat and removing dampness, detoxifying and reducing swelling, and clearing heat and cooling blood; Licorice is used as the messenger drug for tonifying the spleen and harmonizing the stomach, invigorating qi and restoring the pulse, and harmonizing various drugs. The eight drugs are used together to achieve the effects of promoting blood circulation and removing blood stasis, promoting blood circulation and activating collaterals, clearing heat and removing dampness, and nourishing yin and tonifying the kidney.

[0030] The compound Chinese medicine composition for relieving hypertension symptoms provided by the present invention has the following advantages compared with the prior art:

[0031] 1. The present invention is based on the theory of traditional Chinese medicine, combined with the modern research results of hypertension, and adopts the principle of systemic regulation based on syndrome differentiation to screen Chinese medicine prescriptions. The compound Chinese medicine composition preparation provided can synergistically regulate multiple hypertension targets and regulate disease networks, and has a good therapeutic effect on hypertension.

[0032] 2. The experimental results show that the compound Chinese medicine composition for relieving hypertension symptoms provided by the present invention has the effects of promoting blood circulation and removing blood stasis, promoting blood circulation and activating collaterals, clearing away heat and removing dampness, nourishing yin and tonifying the kidney, and simultaneously exerts a multi-target system to relieve hypertension symptoms. In addition, the compound Chinese medicine composition for relieving hypertension symptoms provided by the present invention is highly safe and has very low toxic and side effects.

[0033] 3. The compound Chinese medicine composition for relieving hypertension symptoms provided by the present invention can be prepared into a variety of dosage forms using pharmaceutical carriers / excipients, etc., which is convenient for patients to take. In addition, the compound Chinese medicine composition for relieving hypertension symptoms provided by the present invention has a scientific and reasonable ratio, a small dosage, can quickly exert its efficacy, has a stable preparation process, and is suitable for industrial large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 The figure shows the regulating effect of the Chinese medicine composition preparation of the present invention (batch number: H005, 6g / kg) on ​​the systolic blood pressure of the spontaneously hypertensive SHR rat model. The horizontal axis is the number of days of treatment, and the vertical axis is the systolic blood pressure (SBP) value of the animal model measured in the experiment. The red curve represents the animal group treated with the Chinese medicine composition preparation; the green curve represents the normal control group (blank group); the black curve represents the model animal group; and the blue curve represents the animal group treated with Benaripril Hydrochloride Tablets.

[0035] Figure 2 The figure shows the regulating effect of the Chinese medicine composition preparation of the present invention (batch number: H005, 6g / kg) on ​​the diastolic blood pressure of the spontaneously hypertensive SHR rat model. The horizontal axis is the number of days of treatment, and the vertical axis is the systolic blood pressure (DBP) value of the animal model measured in the experiment. The red curve represents the animal group treated with the Chinese medicine composition preparation; the green curve represents the normal control group (blank group); the black curve represents the model animal group; and the blue curve represents the animal group treated with Benaripril Hydrochloride Tablets.

[0036] Figure 3 The figure shows the changes in the body weight of the rat model after treatment with the Chinese medicine composition preparation of the present invention (batch number: H005, 6g / kg). The horizontal axis is the number of days of treatment, and the vertical axis is the weight (g) value of the animal model measured in the experiment. The red curve represents the animal group treated with the Chinese medicine composition preparation; the green curve represents the normal control group (blank group); the black curve represents the model animal group; and the blue curve represents the animal group treated with Benaripril Hydrochloride Tablets. DETAILED DESCRIPTION

[0037] Example 1

[0038] Take Chinese medicinal raw materials by weight, specifically, 15 grams of Centella asiatica, 20 grams of Fenugreek, 15 grams of Salvia miltiorrhiza, 25 grams of Pueraria root, 15 grams of Eucommia ulmoides, 10 grams of Ginkgo biloba, 15 grams of Lycium bark, and 15 grams of Licorice. Add 12 times (i.e., 1680 mL) of water according to the weight of the prescription amount, decoct together, extract 3 times, each time for 2 hours, filter naturally through a 120-mesh stainless steel mesh, and pass the concentrate through a macroporous adsorption resin column. After elution, further reduce pressure and concentrate to an extract with a relative density of 1.20-1.30, vacuum dry, and ultrafinely grind at low temperature to obtain fine powder, add diluent lactose and corn starch to mix evenly, put into enteric-coated capsules and prepare capsules of the Chinese medicine composition of the present invention (batch number: H001).

[0039] Example 2

[0040] Take Chinese medicinal raw materials by weight, specifically, 5 grams of Centella asiatica, 10 grams of Fenugreek, 5 grams of Salvia miltiorrhiza, 15 grams of Pueraria root, 5 grams of Eucommia ulmoides, 50 grams of Ginkgo biloba, 10 grams of Lycium bark, and 5 grams of Licorice. Add 8 times (i.e. 480 mL) of water according to the weight of the prescription amount and decoct together, filter naturally through a 120-mesh stainless steel mesh, add 10 times by weight of 50% ethanol 600 mL of reflux extraction to the residue, filter naturally through a 120-mesh stainless steel mesh, merge the filtrate, apply the concentrate to a macroporous adsorption resin column, further concentrate under reduced pressure after elution to obtain an extract with a relative density of 1.20-1.30, and after vacuum drying, ultrafinely grind at low temperature to obtain fine powder, add glycerol and sorbitol excipients to prepare an ointment (batch number: H002) of the Chinese medicine composition of the present invention for oral administration.

[0041] Example 3

[0042] Take Chinese medicinal raw materials by weight, specifically, 5 grams of Centella asiatica, 5 grams of ginkgo, 5 grams of Salvia miltiorrhiza, 5 grams of Pueraria root, 5 grams of Eucommia ulmoides, 15 grams of Fenugreek, 5 grams of Lycium bark, and 5 grams of Licorice. Add 8 times of 70% ethanol solution (i.e. 400 mL) according to the weight of the prescription amount, reflux extraction, extract 3 times, each time for 2 hours, filter naturally through a 120-mesh stainless steel mesh, and add the concentrate to a macroporous adsorption resin column. After elution, further reduce pressure and concentrate to an extract with a relative density of 1.20-1.30, vacuum dry and then ultrafinely grind at low temperature to obtain fine powder, add acrylic polymer, polyethylene glycol excipient and binder, and adopt a melting method to prepare the Chinese medicine composition drip pill dosage form of the present invention (batch number: H003).

[0043] Example 4

[0044] Take Chinese medicinal raw materials by weight, specifically, 10 grams of Centella asiatica, 8 grams of ginkgo, 10 grams of Salvia miltiorrhiza, 10 grams of Pueraria root, 10 grams of Eucommia ulmoides, 20 grams of Fenugreek, 10 grams of Lycium bark, and 10 grams of Licorice. Add 10 times (i.e. 900 mL) of water according to the weight of the prescription amount and decoct together, extract 3 times, each time for 2 hours, filter naturally through a 120-mesh stainless steel mesh, and apply a macroporous adsorption resin column to the concentrate. After elution, further reduce pressure and concentrate to an extract with a relative density of 1.20-1.30, vacuum dry, and ultrafinely grind at low temperature to obtain fine powder, add microcrystalline cellulose, sodium carboxymethyl starch, and lubricant magnesium stearate, mix well, and compress to prepare tablets of the Chinese medicine composition of the present invention (batch number: H004).

[0045] Example 5

[0046] Take Chinese medicinal raw materials by weight, specifically, 10 grams of Centella asiatica, 8 grams of ginkgo, 10 grams of Salvia miltiorrhiza, 25 grams of Pueraria root, 8 grams of Eucommia ulmoides, 15 grams of Fenugreek, 10 grams of Lycium bark, and 8 grams of Licorice. Add 10 times (i.e. 980 mL) of water according to the weight of the prescription amount and decoct together, filter naturally through a 120-mesh stainless steel mesh, add 10 times by weight of 70% ethanol 980 mL of reflux extraction to the residue, extract 3 times, each time for 2 hours, filter naturally through a 120-mesh stainless steel mesh, merge the filtrate, apply a macroporous adsorption resin column to the concentrate, further reduce pressure and concentrate after elution to obtain an extract with a relative density of 1.20-1.30, vacuum dry, ultrafinely grind at low temperature to obtain fine powder, add dextrin, and spray to obtain the granules of the Chinese medicine composition of the present invention (batch number: H005).

[0047] Example 6

[0048] The regulating effect of the Chinese medicine composition prepared in the embodiment of the present invention on the symptoms of hypertension was evaluated by the spontaneously hypertensive rats (SHR) model. Spontaneously hypertensive rats are a common animal model for screening antihypertensive drugs. Benaricept hydrochloride tablets are a common drug used clinically to treat hypertension and are used as positive control drugs in the experiment. The following experiments were commissioned to Shanghai Medicilon Biopharmaceutical Co., Ltd.

[0049] After one week of feeding the SHR hypertensive rats (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., experimental animal production license number: SCXK (Beijing) 2021-0006) model during the adaptation period, the systolic and diastolic blood pressure of all animals were measured. After the systolic blood pressure of SHR rats was >140 mmHg, they were divided into 3 groups on average, 6 in each group, plus 6 normal control rats (WYK rats), a total of 4 groups, specifically: normal control group, model group, Benaripi hydrochloride tablets treatment group (dose: 1 mg / kg), and Chinese medicine composition preparation treatment group (batch number: H005, dose: 6 g / kg). After the animals were grouped, they were given solvent control, positive control drug or Chinese medicine composition preparation (H005) by oral gavage once a day for two consecutive weeks. The body weight, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of all animals were measured once a week.

[0050] like Figure 1 to Figure 2 As shown, this experiment shows that the Chinese medicine composition preparation of the present invention has a good regulating effect on the systolic and diastolic blood pressure of the spontaneously hypertensive SHR rat model after treatment, wherein the regulating effect of the Chinese medicine composition preparation of the present invention on systolic blood pressure is close to that of the positive control drug Benaripi Hydrochloride Tablets, proving that the Chinese medicine composition preparation of the present invention has a potential therapeutic effect on abnormal systolic and diastolic blood pressure caused by hypertension.

[0051] In addition, if Figure 3 As shown, the experiment found that the body weight of animals in the treatment group of the Chinese medicine composition preparation of the present invention was reduced to a certain extent compared with the treatment group of Benaricept Hydrochloride Tablets and the model group.

[0052] Example 7

[0053] By examining the acute toxicity data of the Chinese medicine composition preparations of the present invention (batch numbers: H001, H002, H003, H004 and H005), the oral safety of the Chinese medicine composition preparations of the present invention can be understood. 50 healthy ICR rats (SPF level, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., Experimental Animal Production License Number: SCXK (Beijing) 2021-0006) were randomly divided into 5 experimental groups, with 10 rats in each group. The five batches of Chinese medicine composition preparations were formulated into concentrated solutions. After measuring the weight of the mice, the dosage was calculated according to 50g / kg body weight, and the solution was administered orally by gavage. The adverse reaction symptoms of the animals were observed every hour after administration. After 24 hours, the mortality rate of each group of animals was calculated and the adverse reactions were recorded. The experimental results are shown in Table 1. The results show that the acute toxicity values ​​of the five batches of the Chinese medicine composition preparations of the present invention were all LD 50 >50g / kg, no adverse reactions were observed in animals during the experiment, it is non-toxic and has a high oral safety.

[0054] Table 1: Acute toxicity experimental data of the Chinese medicine composition preparation of the present invention

[0055] Group / Batch No. Animals (only) Dead animals (unit) mortality rate(%) H001 10 0 0 H002 10 0 0 H003 10 0 0 H004 10 0 0 H005 10 0 0

[0056] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A Chinese medicine composition for relieving hypertension symptoms, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicine raw materials in parts by weight: 5-15 parts of Centella asiatica, 5-15 parts of Ginkgo biloba, 5-15 parts of Salvia miltiorrhiza, 15-25 parts of Pueraria root, 5-15 parts of Eucommia ulmoides, 10-20 parts of Fenugreek, 5-15 parts of Lycium bark and 5-15 parts of Licorice.

2. The Chinese medicine composition for relieving hypertension symptoms according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicine raw materials in parts by weight: 8-12 parts of Centella asiatica, 5-10 parts of Ginkgo biloba, 8-12 parts of Salvia miltiorrhiza, 20-25 parts of Pueraria root, 5-10 parts of Eucommia ulmoides, 10-20 parts of Fenugreek, 8-12 parts of Lycium bark and 5-10 parts of Licorice.

3. The Chinese medicine composition for relieving hypertension symptoms according to claim 2, characterized in that: The Chinese medicine composition is prepared from the following Chinese medicine raw materials in parts by weight: 10 parts of Centella asiatica, 8 parts of Ginkgo biloba, 10 parts of Salvia miltiorrhiza, 25 parts of Pueraria root, 8 parts of Eucommia ulmoides, 15 parts of Fenugreek, 10 parts of Lycium bark and 8 parts of Licorice.

4. The method for preparing the Chinese medicine composition for relieving hypertension symptoms according to any one of claims 1 to 3, characterized in that: The preparation method is selected from any one of the following: A: Add 5-12 times the amount of water to the Chinese medicinal raw materials in the prescription, decoct together, filter, and concentrate the filtrate; B: Add 50-90% ethanol aqueous solution to the Chinese medicinal raw materials in the prescription amount for reflux extraction, filter, and concentrate the filtrate; C: Add 5-12 times the amount of water to the Chinese medicinal materials in the prescription, decoct and filter; The residues are added with 50-90% ethanol aqueous solution for reflux extraction, filtered, and the filtrates are combined and concentrated.

5. The method for preparing the Chinese medicine composition for relieving hypertension symptoms according to claim 4, characterized in that: In the above method A, method B or method C, water is added and decocted for 1-3 times, and each extraction takes 1-12 hours, preferably 2-4 hours; in the ethanol-water reflux extraction operation, the amount of ethanol-water solution is 8-10 times the weight of the medicinal material, and each extraction takes 1-12 hours, preferably 2-4 hours.

6. A Chinese medicine preparation for relieving hypertension symptoms, characterized in that: The Chinese medicine preparation comprises the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition prepared by the preparation method according to claim 4 or claim 5, and a pharmaceutically acceptable carrier and / or excipient.

7. The Chinese medicine preparation according to claim 6, characterized in that: The pharmaceutically acceptable carrier and / or excipient is selected from one or more of liposomes, microcrystalline cellulose, sodium carboxymethyl starch, sodium carboxymethyl cellulose, polyethylene glycol, polyvinyl alcohol, acrylic polymers, glycerol, propylene glycol, sorbitol, β-cyclodextrin, Tween-80, lactose, starch, Euqite S-100, Euqite L-100, sodium alginate, pectin, and dextrin.

8. The Chinese medicine preparation according to claim 6, characterized in that: The Chinese medicine preparation is granules, capsules, oral liquids, tablets, pills, dripping pills, ointments, decoctions, injections or microcapsules.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3, or the Chinese medicine composition prepared by the preparation method according to claim 4 or claim 5, or the Chinese medicine preparation according to any one of claims 6 to 8 in the preparation of a drug for relieving symptoms of hypertension.

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