Traditional Chinese medicine composition for cough and asthma of old people and preparation method of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for cough and asthma of old people and a preparation method of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicine compositions.The medicinal materials such as peach kernels, angelica sinensis, platycodon grandiflorum, almonds, pear peels and pericarpium citri reticulatae are smashed and decocted together, the effect of moistening the lung to arrest cough can be enhanced through matched use of the pericarpium citri reticulatae and the pear peels, and the traditional Chinese medicine composition is especially effective for cough with phlegm; the peach kernels have the effects of promoting blood circulation, removing blood stasis, relaxing bowel and relieving cough and asthma, the radix angelicae sinensis has the effects of tonifying qi, promoting blood circulation, regulating menstruation, relieving pain and relaxing bowel, and the peach kernels and the radix angelicae sinensis are matched so that the effects of promoting blood circulation and removing blood stasis can be enhanced; the traditional Chinese medicine composition has the effects of tonifying qi, activating blood, tonifying spleen, nourishing stomach, relaxing bowels, promoting diuresis, promoting digestion and circulation and improving the physical state of the patient, so that the chronic intractable cough of the old and weak people is treated by the traditional Chinese medicine composition and the traditional Chinese medicine composition.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating cough and asthma in the elderly and a preparation method thereof. Background Art

[0002] When pathogens or harmful substances such as bacteria, viruses, haze, dust, pollen, and smoke in the air enter the human body, they damage the lungs, causing inflammation and swelling, which can easily cause cough and asthma. Cough and asthma are common respiratory symptom, mainly manifested as cough, wheezing, and shortness of breath. They may be caused by a variety of internal and external factors, such as respiratory tract infections, allergic reactions, foreign bodies in the airways, cardiopulmonary diseases, environmental factors, etc. Among them, common diseases in the elderly and frail population include chronic and stubborn cough and asthma.

[0003] Currently, many Chinese patent medicines for cough and phlegm reduction can promptly reduce inflammation, relieve cough and terminate the disease for acute cough and asthma caused by various pathogens or cold, with good efficacy. However, the chronic and stubborn cough and asthma in the elderly and frail people are not simply caused by pathogens attacking the lungs, but also due to long-term physical weakness, low ability to fight pathogens, and poor qi and blood, which lead to lingering lung damage and make cough and asthma difficult to cure and recur. Summary of the invention

[0004] In order to overcome the above-mentioned defects, the present invention provides a traditional Chinese medicine composition for treating cough and asthma in the elderly and a preparation method thereof, which solves the problem that the elderly have long-term weak constitution, low ability to fight pathogens, poor qi and blood, resulting in lingering lung damage and repeated difficulty in curing cough and asthma.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a traditional Chinese medicine composition for treating cough and asthma in the elderly, comprising the following raw materials in parts by weight: 10-15 parts of polygonatum, 10-15 parts of northern adenophora, 10-15 parts of ophiopogon, 8-10 parts of chrysanthemum, 15-20 parts of mulberry leaf, 5-10 parts of gardenia, 3-8 parts of platycodon, 5-10 parts of almond, 8-10 parts of liquorice, 5-10 parts of pear peel, 5-10 parts of tangerine peel, 10-12 parts of angelica, and 5-10 parts of peach kernel.

[0006] As a further scheme of the present invention: the specific weight parts of the raw materials are 15 parts of polygonatum, 15 parts of northern adenophora, 12 parts of ophiopogon, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot, 8 parts of licorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica, and 10 parts of peach kernel.

[0007] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0008] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0009] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0010] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0011] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0012] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0013] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0014] S7. Perform multiple alcohol precipitation on the filtrate 5, filter it, recover ethanol from the filtrate, concentrate it to obtain a concentrate, adjust the pH value, let it stand and filter it, add water for injection to the obtained filtrate to 1000 mL, seal it, and sterilize it.

[0015] As a further solution of the present invention: in S1, distilled water is used for washing, and the drying temperature is maintained at a low temperature of 35-45°C for drying.

[0016] As a further solution of the present invention: in S2, S3, S4 and S5, the high heat temperature is maintained at 150-300°C, and the low heat temperature is maintained at 50-100°C.

[0017] As a further solution of the present invention: in S6, the medicinal charcoal is activated bamboo charcoal, and the specific adsorption standing time is 30-60 minutes.

[0018] As a further solution of the present invention: in S7, the specific number of alcohol precipitations is two, and the volume concentration of ethanol used in the two alcohol precipitations is 75-85%.

[0019] As a further solution of the present invention: in S7, the relative density of the concentrated solution obtained after concentration at 55-65° C. is 1.10-1.20, and the pH is adjusted to 4.8-5.2.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. In the present invention, peach kernel, angelica, platycodon, apricot kernel, pear peel and tangerine peel are arranged, and the medicinal materials such as peach kernel, angelica, platycodon, apricot kernel, pear peel and tangerine peel are crushed and boiled together, wherein the platycodon total saponin contained in the platycodon has anti-inflammatory and antitussive effects, can reflexively stimulate the hypersecretion of respiratory mucosa, dilute sputum, and promote discharge, and the amygdalin contained in the apricot kernel has an antitussive effect, and the compatibility of platycodon and apricot kernel can dissipate lung and eliminate phlegm, relieve cough and relieve asthma, tangerine peel can regulate qi and invigorate spleen and relieve cough and resolve phlegm, and pear peel can moisten the lung and relieve cough, clear away heat and moisten the lung and reduce fire and promote body fluid, and the combination of tangerine peel and pear peel can enhance the effect of moistening the lung It has an antitussive effect, and is especially effective for coughs with phlegm. It can promote digestion, and can relieve indigestion caused by weak spleen and stomach. Peach kernel has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and promoting bowel movements, as well as relieving cough and asthma, while angelica has the effects of tonifying qi and promoting blood circulation, as well as moistening the intestines and promoting bowel movements. The combination of peach kernel and angelica can enhance the effect of promoting blood circulation and removing blood stasis, improve dry intestines and constipation, and relieve cough and asthma, thereby tonifying qi and promoting blood circulation, tonifying the spleen and stomach, and promoting bowel movement and diuresis for elderly patients, promoting digestive circulation, improving the patient's physical condition and qi and blood health, cooperating with each other, and tonifying and purging in equal measure, thereby treating chronic and stubborn coughs in the elderly and weak population.

[0022] 2. In the present invention, polygonatum, northern adenophora, ophiopogon, chrysanthemum, mulberry leaf, gardenia and licorice are set, and the polygonatum, northern adenophora, ophiopogon, chrysanthemum, mulberry leaf, gardenia and licorice are boiled, wherein the polygonatum can replenish qi and nourish yin, benefit the kidney, improve kidney yin deficiency and soreness of waist and knees, and the polygonatum decoction has anti-fatigue, antioxidant and anti-pathogenic microorganism effects, which is beneficial to improving immunity, and the northern adenophora can nourish yin and clear the lungs, benefit the stomach and produce body fluid, and can improve dry cough with little sputum and dry throat and thirst caused by lung heat damaging yin Ophiopogon japonicus can nourish yin and moisten the lungs, benefit the stomach and produce fluid, thereby improving dry cough due to lung dryness, thirst due to loss of fluid and constipation due to dry intestines. The cooperation between them can enhance the effects of nourishing lung yin, clearing lung heat and moistening lung dryness, and improve the patient's immunity. Chrysanthemum and mulberry leaves can work together to clear away heat and detoxify, dispel wind and clear heat, and can also be antibacterial and anti-inflammatory, dilate blood vessels, and increase myocardial oxygen consumption. Gardenia and licorice can clear away heat and detoxify, purge fire and relieve restlessness, and harmonize various medicines, thereby tonifying the spleen and kidney, clearing the lungs and producing fluid, and improving blood circulation for elderly patients. DETAILED DESCRIPTION

[0023] The technical solution of the present application is further described in detail below in conjunction with specific implementation methods.

[0024] The present invention provides a technical solution: a traditional Chinese medicine composition for treating cough and asthma in the elderly and a preparation method thereof.

[0025] Embodiment 1:

[0026] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0027] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0028] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0029] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0030] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0031] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0032] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0033] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0034] S7. The filtrate 5 is subjected to multiple alcohol precipitations at a precipitation temperature of 28° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and then concentrated to obtain a concentrated solution, and the pH value is adjusted to 5. The concentrated solution is then allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0035] Embodiment 2:

[0036] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0037] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0038] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0039] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0040] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0041] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0042] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0043] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0044] S7. The filtrate 5 is subjected to multiple alcohol precipitations at a precipitation temperature of 30°C and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered and concentrated to obtain a concentrated solution. The pH value is adjusted to 5, and then the concentrated solution is allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0045] Embodiment 3:

[0046] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0047] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0048] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0049] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0050] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0051] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0052] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0053] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0054] S7. The filtrate 5 is subjected to multiple alcohol precipitations at a precipitation temperature of 32° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and then concentrated to obtain a concentrated solution, and the pH value is adjusted to 5. The concentrated solution is then allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0055] Embodiment 4:

[0056] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0057] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0058] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0059] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0060] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0061] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0062] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0063] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0064] S7. The filtrate 5 is subjected to multiple alcohol precipitations at a precipitation temperature of 34° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and then concentrated to obtain a concentrated solution, and the pH value is adjusted to 5. The concentrated solution is then allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0065] Embodiment 5:

[0066] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0067] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0068] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0069] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0070] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0071] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0072] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0073] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0074] S7. The filtrate five is subjected to multiple alcohol precipitations at a precipitation temperature of 36° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and concentrated to obtain a concentrated solution. The pH value is adjusted to 5, and then the concentrated solution is allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0075] Embodiment 6:

[0076] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaf, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 4 parts of angelica, and 3 parts of peach kernel.

[0077] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0078] S1. Weigh the above raw materials by weight, wash, dry, mix and crush;

[0079] S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate;

[0080] S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2;

[0081] S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3;

[0082] S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four;

[0083] S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5;

[0084] S7. The filtrate 5 is subjected to multiple alcohol precipitations at a precipitation temperature of 32° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and then concentrated to obtain a concentrated solution, and the pH value is adjusted to 5. The concentrated solution is then allowed to stand and filtered. Water for injection is added to the obtained filtrate to 1000 mL, and the solution is sealed and sterilized.

[0085] Comparative Example:

[0086] A traditional Chinese medicine composition for treating cough and asthma in the elderly is composed of the following raw materials in parts by weight: specific parts by weight of the raw materials are 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

[0087] A method for preparing a traditional Chinese medicine composition for treating cough and asthma in the elderly, the method comprising the following steps:

[0088] Weigh the above raw materials by weight, wash and dry them, then mix and crush them;

[0089] Put the mixed raw materials into a casserole, and pour in water 10-15 times the weight of the raw materials, soak for 1-2 hours, then boil over high heat, then simmer over low heat until the amount of water is reduced by half, and finally filter the decoction to obtain a residue and a filtrate;

[0090] Adding medicinal charcoal to the obtained filtrate for adsorption, filtering after standing to obtain a primary filtrate;

[0091] The primary filtrate is subjected to multiple alcohol precipitations at an alcohol precipitation temperature of 32° C. and an ethanol volume concentration of 80%. The filtrate is filtered, and the ethanol is recovered from the filtrate and then concentrated to obtain a concentrated solution, and the pH value is adjusted to 5. The concentrated solution is then allowed to stand and filtered. Water for injection is added to the final filtrate to 1000 mL, and the solution is sealed and sterilized.

[0092] The following table is obtained by filtering the solutions obtained by alcohol precipitation at different alcohol precipitation temperatures in Examples 1 to 6, observing and comparing the amounts of precipitates obtained by filtration in Examples 1 to 6, and observing patients with the same number of days of drinking during treatment:

[0093]

[0094] By comparing and observing the precipitates obtained by filtration in Examples 1 to 6, when the ethanol volume concentration and precipitation time are the same but the precipitation temperature is different, the precipitation temperature of 32°C in Example 3 has the best effect, and the effect of the precipitate obtained gradually decreases as the temperature gradually increases. The proportion of angelica and peach kernel in Example 3 is higher than that in Example 6, so Example 3 is the best choice in terms of medicinal material proportion.

[0095] The contents of the active ingredients in Example 3 and the comparative example were observed and compared with each other, and the following table was obtained by observing the patients who had the same number of days of drinking for treatment:

[0096]

[0097] The difference between Example 3 and Comparative Example is:

[0098] In the comparative example, a single process of decocting, filtering and precipitating all raw materials was used to prepare the Chinese medicine composition. The single process preparation method made it difficult to completely precipitate the active ingredients in the raw materials.

[0099] In Example 3, a Chinese medicine composition is prepared by decocting, filtering and precipitating all raw materials in multiple steps, and the filter residue 1, filter residue 2, filter residue 3 and filter residue 4 are soaked, decocted and filtered step by step to collect the filtrate, so that the effective components in the raw materials can be fully precipitated;

[0100] By comparing Example 3 with the comparative example, it can be seen that impurities in the medicinal raw materials can affect the content of the active ingredient in a portion of the medicine, thereby affecting the patient's absorption and utilization of the medicine during the treatment process. Therefore, the medicinal material portion calculation of Example 3 is the best.

[0101] From the above we know:

[0102] By crushing and boiling medicinal materials such as peach kernel, angelica, platycodon, apricot kernel, pear peel and tangerine peel together, peach kernel can promote blood circulation and remove blood stasis, moisten the intestines and relieve constipation, as well as relieve cough and asthma, while angelica can replenish qi and promote blood circulation, regulate menstruation and relieve pain, as well as moisten the intestines and relieve constipation. The combination of peach kernel and angelica can enhance the effect of promoting blood circulation and removing blood stasis, improve dry intestines and constipation, and relieve cough and asthma, thereby replenishing qi and promoting blood circulation, nourishing the spleen and stomach, promoting digestive circulation, improving the patient's physical condition and blood health, and thus treating chronic and stubborn cough in the elderly and weak population.

[0103] In the description of the present invention, it is necessary to understand that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "axial", "radial", "circumferential" and the like, which indicate orientations or positional relationships, are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0104] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0105] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or a communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0106] In the present invention, unless otherwise clearly specified and limited, the first feature "on" or "under" the second feature may be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. In the description of this specification, the description with reference to the terms "one scheme", "some schemes", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the scheme or example are included in at least one scheme or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same scheme or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more schemes or examples in a suitable manner.

Claims

1. A Chinese medicine composition for treating cough and asthma in the elderly, characterized in that: The Chinese medicine composition comprises the following raw materials by weight: 10-15 parts of polygonatum, 10-15 parts of northern adenophora, 10-15 parts of ophiopogon, 8-10 parts of chrysanthemum, 15-20 parts of mulberry leaves, 5-10 parts of gardenia, 3-8 parts of platycodon, 5-10 parts of almond, 8-10 parts of liquorice, 5-10 parts of pear peel, 5-10 parts of tangerine peel, 10-12 parts of angelica, and 5-10 parts of peach kernel.

2. A Chinese medicine composition for treating cough and asthma in the elderly according to claim 1, characterized in that: The specific weight parts of the raw materials are as follows: 15 parts of polygonatum, 15 parts of adenophora adenophora, 12 parts of ophiopogon japonicus, 9 parts of chrysanthemum, 15 parts of mulberry leaves, 8 parts of gardenia, 6 parts of platycodon, 7 parts of apricot kernel, 8 parts of liquorice, 7 parts of pear peel, 7 parts of tangerine peel, 12 parts of angelica sinensis, and 10 parts of peach kernel.

3. A method for preparing a Chinese medicine composition for treating cough and asthma in the elderly, according to claim 2, characterized in that: The preparation method comprises the following steps: S1. Weigh the above raw materials by weight, wash, dry, mix and crush; S2, putting the mixed raw materials into a casserole, and pouring 10-15 times the weight of the medicinal raw materials into water, soaking for 1-2 hours, then boiling with high heat, and then decocting with low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain a filter residue and a filtrate; S3, adding 8-12 times the weight of the medicinal material to the obtained filter residue 1, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 2 and filtrate 2; S4, adding 6-8 times the weight of the medicinal material to the obtained filter residue 2, soaking for 20-40 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue 3 and filtrate 3; S5, adding 4-6 times the weight of the medicinal material to the obtained filter residue three, soaking for 10-20 minutes, then boiling over high heat, then decocting over low heat until the amount of water is reduced by half, and finally filtering the decoction to obtain filter residue four and filtrate four; S6, mixing the obtained filtrate 1, filtrate 2, filtrate 3 and filtrate 4, adding medicinal charcoal for adsorption, letting stand and filtering to obtain filtrate 5; S7. Perform multiple alcohol precipitation on the filtrate 5, filter it, recover ethanol from the filtrate, concentrate it to obtain a concentrate, adjust the pH value, let it stand and filter it, add water for injection to the obtained filtrate to 1000 mL, seal it, and sterilize it.

4. The method for preparing a Chinese medicine composition for treating cough and asthma in the elderly according to claim 3, characterized in that: In S1, distilled water is used for washing, and the drying temperature is maintained at a low temperature of 35-45°C for drying.

5. The method for preparing a Chinese medicine composition for treating cough and asthma in the elderly according to claim 3, characterized in that: In S2, S3, S4 and S5, the high heat temperature is maintained at 150-300°C, and the low heat temperature is maintained at 50-100°C.

6. The method for preparing a Chinese medicine composition for treating cough and asthma in the elderly according to claim 3, characterized in that: In S6, the medicinal charcoal is activated bamboo charcoal, and the specific adsorption standing time is 30-60 minutes.

7. The method for preparing a Chinese medicine composition for treating cough and asthma in the elderly according to claim 3, characterized in that: In S7, the specific number of alcohol precipitations is two, and the volume concentration of ethanol used in the two alcohol precipitations is 75-85%.

8. The method for preparing a Chinese medicine composition for treating cough and asthma in the elderly according to claim 3, characterized in that: In the above S7, the relative density of the concentrated solution obtained after concentration at 55-65° C. is 1.10-1.20, and the pH is adjusted to 4.8-5.2.

Images