Gel for treating gingival atrophy and repairing oral mucosa as well as preparation method and application of gel

Abstract

The invention discloses gel for treating gingival atrophy and repairing oral mucosa as well as a preparation method and application of the gel, and relates to the technical field of medicines.The gel for treating gingival atrophy and repairing the oral mucosa comprises 40-60 parts of purified water. The oral liquid is prepared from the following components in parts by weight: 15-30 parts of a fish scale gelatin excipient, 10-25 parts of a traditional Chinese medicine extracting solution, 4-12 parts of sorbitol, 3-8 parts of a preservative, 5-15 parts of a surfactant, 0.01-0.05 part of sodium alginate and 0.05-0.2 part of chlorhexidine gluconate. According to the preparation method and application of the high-adhesive-force traditional Chinese medicine hydrogel for treating gingival atrophy and repairing the oral mucosa, the medicines in the composition are precisely compatible and have a synergistic effect, the fish scale gelatin is used as a monarch drug, the other components are used as ministerial drugs and monarch, minister, assistant and guide drugs, the effects of broad-spectrum antibiosis, analgesia and inflammation diminishing, qi benefiting and blood nourishing and oral mucosa repairing can be achieved, and the traditional Chinese medicine hydrogel has a wide application prospect in treating gingival atrophy and repairing the oral mucosa. The traditional Chinese medicine composition can be used for solving the problems of gingival atrophy, insufficient antibacterial ability, poor oral mucosa repair and the like.

Description

Technical Field

[0001] The invention relates to the field of medical technology, in particular to a gel for treating gingival atrophy and repairing oral mucosa, a preparation method and application thereof. Background Art

[0002] Oral diseases are common diseases among Chinese residents. They have a high prevalence, affect overall health and quality of life, and impose a huge burden on society and the economy. They have become an important public health issue. According to the fourth national oral health epidemiological survey, as many as 97% of adults in China are suffering from oral problems. Among them, 97% of adults suffer from dental calculus, 88% of adults suffer from caries, and 85% of adults have gum problems. In addition, there are a series of problems such as tooth sensitivity, bad breath, tooth stains, and dental plaque.

[0003] Gingival atrophy is also known as "tooth atrophy" in traditional Chinese medicine, which refers to the gradual shrinkage of the gums. Weak constitution or long-term illness will lead to insufficient qi and blood, which cannot transport essence to the gums, causing the gums to lose nutrition. In addition, pathogenic factors will take advantage of the weakness to invade the gums, resulting in atrophy. Qi deficiency cannot absorb blood, and blood does not flow through the meridians, so it seeps out from the gums, causing this disease. Tooth-eye atrophy rarely occurs alone in clinical practice, and is often accompanied by exposed gums, loose teeth, gum ulcers, bleeding gums, and severe tooth loss.

[0004] In addition to mechanical stimulation and aging changes, gum atrophy is often caused by atrophic periodontitis in Western medicine. Dental plaque is one of the main factors causing periodontitis. Dental plaque is mostly formed by bacteria on the surface of teeth combined with oral mucosal secretions due to poor oral hygiene. It is usually stubborn and difficult to remove. If it is not improved for a long time, it will damage the tooth substance, gradually invade the teeth, and form caries inside. In addition, the accumulation of bacteria will also induce gingivitis and periodontitis.

[0005] For oral problems, the publication number CN112138075A discloses a Chinese medicine composition for repairing loose teeth, gum atrophy and periodontal problems, which is prepared from the following raw materials in parts by weight: 20 parts of Eclipta prostrata, 25 parts of Gleditsia sinensis, 10 parts of Poria cocos, 3 parts of Angelica dahurica, 10 parts of Mangcao, 2 parts of Tortoise Shell, 10 parts of Saposhnikovia divaricata, 5 parts of Licorice, 0.5 parts of Borneolum, 5 parts of Atractylodes macrocephala, 10 parts of Dioscorea opposita, and the Chinese medicine composition in this invention has a relatively mild property. Another example is the publication number CN114984134A discloses a Chinese medicine composition, preparation and preparation method and application for treating tooth pain, gum hyperplasia and gum atrophy diseases. It includes the following raw materials in parts by weight: 400-600 parts of Scoparia scoparia, 160-240 parts of Allium chinense, 80-120 parts of Asarum, and 160-240 parts of Gypsum Fibrosum. This invention uses Scopolamine as the main medicine, Allium sibiricum, Asarum, and Gypsum as the auxiliary medicines, supplemented with white wine, and local medication can quickly suppress tooth and gum pain. This invention has bactericidal and anti-inflammatory effects, but the introduction of white wine during use will cause low patient compliance, and has no good effect on subsequent oral mucosa repair and other problems. For this reason, we propose a gel for treating gingival atrophy and repairing oral mucosa, a preparation method and an application. Summary of the invention

[0006] The purpose of the present invention is to provide a gel for treating gingival atrophy and repairing oral mucosa, a preparation method and application thereof, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a gel for treating gingival atrophy and repairing oral mucosa, comprising 40-60 parts of purified water, 15-30 parts of fish scale gel excipient, 10-25 parts of traditional Chinese medicine extract, 4-12 parts of sorbitol, 3-8 parts of preservative, 5-15 parts of surfactant, 0.01-0.05 parts of sodium alginate, and 0.05-0.2 parts of chlorhexidine gluconate.

[0008] The traditional Chinese medicine extract comprises 60-200 parts of bletilla striata, 150-300 parts of angelica dahurica, 200-400 parts of white ampelopsis thunbergii and 5-30 parts of mint.

[0009] A method for preparing a gel for treating gingival atrophy and repairing oral mucosa comprises the following steps:

[0010] S1. Extracting fish scale glue to obtain fish scale glue solution;

[0011] S2, preparation of Chinese medicine powder, immersing the Chinese medicine in liquid nitrogen for 1-5 minutes, quickly taking out the Chinese medicine from the liquid nitrogen, and grinding the Chinese medicine into powder particles of 200-300 meshes by a grinding component;

[0012] S3, preparation of aqueous extract of Chinese medicine components, placing the Chinese medicine powder obtained in S2 in pure water according to a certain proportion, extracting at 60-100° C. for 30-90 min, filtering, and collecting the aqueous extract of Chinese medicine and Chinese medicine granules respectively;

[0013] S4, preparation of the oil phase extract of the Chinese medicine component, placing the Chinese medicine particles collected in S3 in vegetable oil, extracting at 60-120° C. for 30-90 min, filtering, and collecting the Chinese medicine oil phase extract;

[0014] S5. Preparation of a composition for treating gingival atrophy and repairing oral mucosa. Dissolve fish scale glue solution, sorbitol, sodium alginate, preservatives and chlorhexidine gluconate in pure water in the above proportions with stirring. After fully dissolved, add the aqueous extract and oil extract of traditional Chinese medicine. After mixing evenly, add a surfactant for emulsification at a speed of 3000-5000 r / min. Fully emulsify for 30-120 min to obtain a composition for treating gingival atrophy and repairing oral mucosa.

[0015] The preparation method and application of a Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa with strong adhesion of the present invention is a preferred embodiment, in which the drugs in the composition are accurately matched and synergistic. Fish scale glue is used as the main drug, and the other components are used as the auxiliary drugs. The main, auxiliary and auxiliary drugs can play the role of broad-spectrum antibacterial, analgesic and anti-inflammatory, qi-invigorating and blood-nourishing, and oral mucosa repair, and can be used for problems such as gingival atrophy, insufficient antibacterial ability, and poor oral mucosa repair.

[0016] As a preferred embodiment, liquid nitrogen is used to rapidly freeze the Chinese herbal medicine components in S2. Ultra-low temperature rapid freezing can grind the Chinese herbal medicine components more fully, while being conducive to the exudation of beneficial substances, without changing the medicinal properties of each Chinese herbal medicine, thereby improving the synergistic effect between the various Chinese herbal medicines.

[0017] As a preferred embodiment, in S3 and S4, the Chinese medicinal components are extracted successively using water phase and oil phase, which can ensure that the active ingredients are fully extracted.

[0018] As a preferred embodiment, in S4, the vegetable oil used is one of olive oil, soybean oil, corn germ oil and rapeseed oil.

[0019] As a preferred embodiment, in S5, a surfactant is used to fully emulsify the water phase and the oil phase to avoid oil-water stratification and make the product more uniform. The surfactant used can be one or more of fatty acid glyceride, Tween 20 (polysorbate 20), Tween 40 (polysorbate 40), Tween 80 (polysorbate 60), Span 60, and Span 80.

[0020] As a preferred embodiment, in S5, the water-soluble antibacterial ingredient chlorhexidine gluconate is added to the composition to enhance the antibacterial effect.

[0021] Preferably, the preparation method of the gel for treating gum atrophy and repairing oral mucosa is characterized in that the grinding assembly comprises a grinding cylinder, the grinding cylinder is provided with a discharge port, a cover plate for covering the inside of the grinding cylinder is arranged above the grinding cylinder, a cutting assembly for grinding and cutting materials is arranged on the grinding cylinder, a bearing plate for carrying the cut and ground materials is arranged inside the grinding cylinder, the bearing plate and the inside of the grinding cylinder are matched with each other, a lifting assembly for lifting and lowering the bearing plate and a guiding assembly for guiding during the lifting process are arranged on the grinding cylinder, a connecting assembly for assisting the connection of the cover plate is arranged between the cover plate and the grinding cylinder, and a sealing assembly for sealing the inside of the grinding cylinder after covering is arranged on the cover plate;

[0022] The sealing component comprises an annular groove opened on the outer side of the cover plate, an annular airbag is installed inside the annular groove, and an inflation component for inflating the inside of the annular airbag is arranged between the cover plate and the inside of the grinding cylinder.

[0023] Preferably, the inflation component is provided with multiple groups, and the inflation component includes a piston cylinder fixed to the lower end of the cover plate, one end of the piston cylinder is communicated with the interior of the annular airbag, a piston rod is slidably connected to the piston cylinder, a circular plate is fixed to one end of the piston rod, a retaining ring is fixed to the outside of the piston cylinder, a first spring is sleeved on the outside of the piston cylinder, the two ends of the first spring are respectively connected to the retaining ring and the circular plate, and a push plate for resisting the circular plate for transmission is fixed to the inside of the grinding cylinder.

[0024] Preferably, the connecting assembly includes two groups of symmetrically arranged fixing plates fixed to the outer side of the cover plate, a T-shaped rod is slidably connected to the fixing plate, a connecting plate is fixed to one end of the T-shaped rod, the connecting plate is fixed to the outer side of the grinding cylinder, and a second spring is sleeved on the outer side of the T-shaped rod.

[0025] Preferably, the cutting assembly includes a mounting bracket fixed to the lower end of the grinding cylinder, a mounting shaft is rotatably connected between the mounting bracket and the grinding cylinder, a cutting blade is detachably mounted on one end of the mounting shaft located inside the grinding cylinder through bolts, a first motor for driving the mounting shaft is mounted on the mounting bracket, a sliding hole is provided on the supporting plate, and the supporting plate is slidably connected to the outer side of the mounting shaft through the sliding hole.

[0026] Preferably, the lifting assembly includes a threaded tube rotatably connected to the inside of the grinding cylinder, a threaded rod is threadedly engaged on the threaded tube, the threaded rod is fixed to the lower end of the supporting plate, and a second motor for driving the threaded tube is installed at the lower end of the grinding cylinder.

[0027] Preferably, the guide assembly comprises a sleeve fixed inside the grinding cylinder, a sliding rod is slidably connected to the sleeve, and one end of the sliding rod is fixed to the lower end of the bearing plate.

[0028] Preferably, the gel for treating gum atrophy and repairing oral mucosa is used in treating gum atrophy, repairing oral mucosal damage, treating oral ulcers, and relieving oral inflammation.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] 1. The preparation method and application of a Chinese medicine hydrogel with strong adhesion for treating gingival atrophy and repairing oral mucosa of the present invention, the drugs in the composition are accurately matched and synergistic, with fish scale glue as the main drug and the other components as the auxiliary drugs, which can play the role of broad-spectrum antibacterial, analgesic and anti-inflammatory, qi-invigorating and blood-nourishing, and oral mucosa repairing, and can be used for problems such as gingival atrophy, insufficient antibacterial ability, and poor oral mucosa repair.

[0031] 2. In the process of preparing the strong adhesion Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa of the present invention, the interior of the grinding cylinder is sealed by the mutual cooperation of the sealing components on the grinding component. The sealing effect can prevent the material powder from being in a low-temperature state during the grinding process, which is easy to absorb moisture in the air and agglomerate, and may fly under the action of the airflow generated by grinding, thereby further ensuring the grinding effect of the Chinese medicine raw materials taken out from liquid nitrogen. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a schematic diagram of the preparation process of the gel for treating gum atrophy and repairing oral mucosa of the present invention;

[0033] Figure 2 It is a schematic diagram of the structure of the grinding assembly of the present invention;

[0034] Figure 3 It is a schematic diagram of the structure of the cutting assembly of the present invention;

[0035] Figure 4 It is a schematic diagram of the structure of the connection assembly of the present invention;

[0036] Figure 5 It is a schematic diagram of the sealing assembly structure of the present invention;

[0037] Figure 6 It is a schematic diagram of the structure of the inflatable component of the present invention;

[0038] Figure 7 This is a schematic diagram of the structure of the present invention;

[0039] Figure 8 It is a schematic diagram of the structure of the lifting assembly and the guide assembly of the present invention.

[0040] In the figure: 101-grinding cylinder; 102-discharging port; 103-cover plate; 201-mounting frame; 202-first motor; 203-mounting shaft; 204-cutting blade; 3-carrying plate; 401-threaded tube; 402-threaded rod; 403-second motor; 501-sleeve; 502-slide rod; 601-fixing plate; 602-T-rod; 603-connecting plate; 604-second spring; 701-annular groove; 702-annular airbag; 801-piston cylinder; 802-piston rod; 803-round plate; 804-blocking ring; 805-first spring; 806-push plate. DETAILED DESCRIPTION

[0041] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Embodiment 1

[0043] See also Figure 1 , a gel for treating gingival atrophy and repairing oral mucosa, including 40-60 parts of purified water, 15-30 parts of fish scale gel excipient, 10-25 parts of Chinese medicine extract, 4-12 parts of sorbitol, 3-8 parts of preservative, 5-15 parts of surfactant, 0.01-0.05 parts of sodium alginate, and 0.05-0.2 parts of chlorhexidine gluconate.

[0044] The traditional Chinese medicine extract comprises 60-200 parts of bletilla striata, 150-300 parts of angelica dahurica, 200-400 parts of white ampelopsis thunbergii and 5-30 parts of mint.

[0045] A method for preparing a gel for treating gingival atrophy and repairing oral mucosa, characterized in that it comprises the following steps:

[0046] S1: Extraction of fish scale gelatin excipients to obtain fish scale gelatin solution, the method refers to "a fish scale collagen protein and its preparation method and application", patent number is ZL201811162213.9;

[0047] S2: Preparation of Chinese medicinal powders of Bletilla striata, Angelica dahurica, Radix Ampelopsis and Mentha chinensis. 60 parts of Bletilla striata, 150 parts of Angelica dahurica, 200 parts of Radix Ampelopsis and 5 parts of Mentha chinensis were immersed in liquid nitrogen for 1 min respectively, and the Chinese medicinal materials were quickly taken out of the liquid nitrogen and ground into powdery particles of 200 mesh;

[0048] S3: Preparation of aqueous extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The powder of the Chinese medicine obtained in S2 was placed in pure water according to the proportion, extracted at 60°C for 30min, filtered, and the aqueous extract of the Chinese medicine and the Chinese medicine granules were collected respectively;

[0049] S4: Preparation of oil phase extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The Chinese medicine particles collected in S3 were placed in olive oil, extracted at 60°C for 30 min, filtered, and the oil phase extracts of the Chinese medicine were collected;

[0050] S5: Preparation of a composition for treating gingival atrophy and repairing oral mucosa. 15 parts of fish scale glue solution, 4 parts of sorbitol, 0.01 parts of sodium alginate, 3 parts of preservatives, and 0.05 parts of chlorhexidine gluconate are stirred and dissolved in 40 parts of pure water according to the above proportions. After sufficient dissolution, 6 parts of Chinese medicine aqueous phase extract and 4 parts of oil phase extract are added. After mixing evenly, 3 parts of Tween 20 and 3 parts of Tween 80 emulsifying surfactants are added for emulsification at an emulsification speed of 3000 r / min. After sufficient emulsification for 60 minutes, a composition for treating gingival atrophy and repairing oral mucosa is obtained.

[0051] Embodiment 2

[0052] The preparation method and application of a Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa strong adhesion comprises the following steps:

[0053] S1: Extraction of fish scale gelatin excipients to obtain fish scale gelatin solution, the method refers to "a fish scale collagen protein and its preparation method and application", patent number is ZL201811162213.9;

[0054] S2: Preparation of Chinese medicinal powders of Bletilla striata, Angelica dahurica, Radix Ampelopsis and Mentha chinensis. 100 parts of Bletilla striata, 150 parts of Radix Angelicae Dahuricae, 250 parts of Radix Ampelopsis and 10 parts of Mentha chinensis were immersed in liquid nitrogen for 2 min respectively, and the Chinese medicinal materials were quickly taken out from the liquid nitrogen and ground into powdery particles of 300 mesh;

[0055] S3: Preparation of aqueous extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The Chinese medicine powder obtained in S2 was placed in pure water according to the proportion, extracted at 80°C for 60min, filtered, and the aqueous extracts and Chinese medicine granules were collected respectively;

[0056] S4: Preparation of oil phase extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The Chinese medicine particles collected in S3 were placed in soybean oil, extracted at 70°C for 60 min, filtered, and the oil phase extracts of the Chinese medicine were collected;

[0057] S5: Preparation of a composition for treating gingival atrophy and repairing oral mucosa. Dissolve 20 parts of fish scale glue solution, 6 parts of sorbitol, 0.02 parts of sodium alginate, 5 parts of preservatives and 0.01 parts of chlorhexidine gluconate in 50 parts of pure water in the above proportions by stirring. After fully dissolved, add the aqueous extract and the oil extract of traditional Chinese medicine. After mixing evenly, add 5 parts of Span 80 and 5 parts of Tween 80, a surfactant, for emulsification at an emulsification speed of 4000 r / min. Fully emulsify for 60 minutes to obtain a composition for treating gingival atrophy and repairing oral mucosa.

[0058] Embodiment 3

[0059] The preparation method and application of a Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa strong adhesion comprises the following steps:

[0060] S1: Extraction of fish scale gelatin excipients to obtain fish scale gelatin solution, the method refers to "a fish scale collagen protein and its preparation method and application", patent number is ZL201811162213.9;

[0061] S2: Preparation of Chinese medicinal powders of Bletilla striata, Angelica dahurica, Radix Ampelopsis and Mentha chinensis. Immerse 200 parts of Bletilla striata, 300 parts of Angelica dahurica, 400 parts of Radix Ampelopsis and 30 parts of Mentha chinensis in liquid nitrogen for 5 minutes respectively, quickly take out the Chinese medicinal materials from the liquid nitrogen, and grind them into powder particles of 200 mesh;

[0062] S3: Preparation of aqueous extracts of Bletilla striata, Angelica dahurica, Ampelopsis pilosula and Mentha arvense, the Chinese medicine powder obtained in S2 was placed in pure water according to the proportion, extracted at 100°C for 90min, filtered, and the aqueous extracts and Chinese medicine particles were collected respectively;

[0063] S4: Preparation of oil phase extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense, the Chinese medicine particles collected in S3 were placed in olive oil and extracted at 120°C for 90 minutes. Filter and collect the oil phase extracts of Chinese medicine.

[0064] S5: Preparation of a composition for treating gingival atrophy and repairing oral mucosa. 30 parts of fish scale glue solution, 12 parts of sorbitol, 0.05 parts of sodium alginate, 8 parts of preservatives and 0.2 parts of chlorhexidine gluconate are stirred and dissolved in 60 parts of pure water according to the above proportions. After sufficient dissolution, 15 parts of Chinese medicine aqueous phase extract and 10 parts of oil phase extract are added. After mixing evenly, 15 parts of surfactant fatty acid glyceride are added for emulsification at an emulsification speed of 5000r / min. After sufficient emulsification for 120min, the composition for treating gingival atrophy and repairing oral mucosa is obtained.

[0065] Embodiment 4

[0066] The preparation method and application of a Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa strong adhesion comprises the following steps:

[0067] S1: Extraction of fish scale gelatin excipients to obtain fish scale gelatin solution, the method refers to "a fish scale collagen protein and its preparation method and application", patent number is ZL201811162213.9;

[0068] S2: Preparation of Chinese medicinal powders of Bletilla striata, Angelica dahurica, Radix Ampelopsis and Mentha chinensis. 150 parts of Bletilla striata, 300 parts of Radix Angelicae Dahuricae, 300 parts of Radix Ampelopsis and 10 parts of Mentha chinensis were immersed in liquid nitrogen for 3 min respectively, and the Chinese medicinal materials were quickly taken out from the liquid nitrogen and ground into powdery particles of 300 mesh;

[0069] S3: Preparation of aqueous extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense, the Chinese medicine powder obtained in S2 was placed in pure water according to the proportion, extracted at 90°C for 90min, filtered, and the aqueous extracts and Chinese medicine granules were collected respectively;

[0070] S4: Preparation of oil phase extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense, the Chinese medicine particles collected in S3 were placed in corn germ oil, extracted at 100°C for 80min, filtered, and the oil phase extracts of the Chinese medicine were collected;

[0071] S5: Preparation of a composition for treating gingival atrophy and repairing oral mucosa. 30 parts of fish scale glue solution, 10 parts of sorbitol, 0.04 parts of sodium alginate, 6 parts of preservatives, and 0.1 parts of chlorhexidine gluconate are stirred and dissolved in 55 parts of pure water according to the above proportions. After sufficient dissolution, 10 parts of Chinese medicine aqueous phase extract and 10 parts of oil phase extract are added. After mixing evenly, 5 parts of Span 60 and 10 parts of Tween 40 surfactants are added for emulsification at an emulsification speed of 5000 r / min. After sufficient emulsification for 120 minutes, the composition for treating gingival atrophy and repairing oral mucosa is obtained.

[0072] Embodiment 5

[0073] The preparation method and application of a Chinese medicine hydrogel for treating gingival atrophy and repairing oral mucosa strong adhesion comprises the following steps:

[0074] S1: Extraction of fish scale gelatin excipients to obtain fish scale gelatin solution, the method refers to "a fish scale collagen protein and its preparation method and application", patent number is ZL201811162213.9;

[0075] S2: Preparation of Chinese medicinal powders of Bletilla striata, Angelica dahurica, Radix Ampelopsis and Mentha chinensis. 200 parts of Bletilla striata, 150 parts of Radix Angelicae Dahuricae, 200 parts of Radix Ampelopsis and 5 parts of Mentha chinensis were immersed in liquid nitrogen for 5 minutes respectively, and the Chinese medicinal materials were quickly taken out of the liquid nitrogen and ground into powdery particles of 300 mesh;

[0076] S3: Preparation of aqueous extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The powder of the Chinese medicine obtained in S2 was placed in pure water according to the proportion and extracted at 80°C for 80 min. Filter and collect the aqueous extract of the Chinese medicine and the Chinese medicine granules respectively;

[0077] S4: Preparation of oil phase extracts of Bletilla striata, Angelica dahurica, Ampelopsis radix and Mentha arvense. The Chinese medicine particles collected in S3 were placed in rapeseed oil and extracted at 70°C for 90 minutes. Filter and collect the oil phase extracts of Chinese medicine;

[0078] S5: Preparation of a composition for treating gum atrophy and repairing oral mucosa. 20 parts of fish scale glue solution, 12 parts of sorbitol, 0.03 parts of sodium alginate, 5 parts of preservatives, and 0.15 parts of chlorhexidine gluconate were stirred and dissolved in 60 parts of pure water according to the above proportions. After fully dissolved, 12 parts of Chinese medicine aqueous phase extract and 8 parts of oil phase extract were added. After mixing evenly, 5 parts of fatty acid glyceride and 5 parts of Tween 80 surfactants were added for emulsification at an emulsification speed of 4000 r / min. The emulsification was fully emulsified for 100 minutes to obtain a composition for treating gum atrophy and repairing oral mucosa.

[0079] Implementation Six

[0080] See also Figure 2-8 In this solution, the grinding assembly includes:

[0081] A grinding cylinder 101, a discharge port 102 is provided on the grinding cylinder 101, a cover plate 103 for covering the inside of the grinding cylinder 101 is provided above the grinding cylinder 101, a cutting assembly for grinding and cutting materials is provided on the grinding cylinder 101, a carrying plate 3 for carrying the cut and ground materials is provided inside the grinding cylinder 101, the carrying plate 3 and the inside of the grinding cylinder 101 are matched with each other, a lifting assembly for lifting and lowering the carrying plate 3 and a guiding assembly for guiding during the lifting process are provided on the grinding cylinder 101, a connecting assembly for assisting the connection of the cover plate 103 is provided between the cover plate 103 and the grinding cylinder 101, and a sealing assembly for sealing the inside of the grinding cylinder 101 after covering is provided on the cover plate 103;

[0082] The sealing component includes an annular groove 701 opened on the outer side of the cover plate 103, an annular airbag 702 is installed inside the annular groove 701, and an inflation component for inflating the inside of the annular airbag 702 is arranged between the cover plate 103 and the inside of the grinding cylinder 101; when the cover plate 103 is reset toward the inside of the grinding cylinder 101, the inside of the annular airbag 702 is inflated through the inflation component, and during the inflation process, the annular airbag 702 expands under the action of pressure and tightly abuts against the inner wall of the grinding cylinder 101, thereby sealing the inside of the grinding cylinder 101.

[0083] The inflatable assembly is provided with multiple groups, and the inflatable assembly includes a piston cylinder 801 fixed to the lower end of the cover plate 103, one end of the piston cylinder 801 is connected to the inside of the annular airbag 702, a piston rod 802 is slidably connected to the piston cylinder 801, a circular plate 803 is fixed to one end of the piston rod 802, a retaining ring 804 is fixed to the outside of the piston cylinder 801, a first spring 805 is sleeved on the outside of the piston cylinder 801, and the two ends of the first spring 805 are respectively connected to the retaining ring 804 and the circular plate 803, and the inner part of the grinding cylinder 101 is fixed There is a push plate 806 for resisting and transmitting with the circular plate 803; during the process of resetting the cover plate 103 toward the inside of the grinding cylinder 101, the circular plate 803 at the front end of the piston rod 802 on each group of inflation components is respectively resisted with each group of push plates 806, and during the resisting process, each group of piston rods 802 are pushed to move toward the inside of each group of piston cylinders 801, and during the movement of the piston rod 802, part of the gas inside the piston cylinder 801 is squeezed and transported to the inside of the annular airbag 702, so that the inside of the annular airbag 702 is inflated.

[0084] The connecting assembly includes two groups of symmetrically arranged fixing plates 601 fixed to the outside of the cover plate 103, a T-shaped rod 602 is slidably connected to the fixing plate 601, a connecting plate 603 is fixed to one end of the T-shaped rod 602, the connecting plate 603 is fixed to the outside of the grinding cylinder 101, and a second spring 604 is sleeved on the outside of the T-shaped rod 602; through the mutual cooperation between the fixing plate 601 and the T-shaped rod 602, the slidable connection of the auxiliary cover plate 103 is facilitated, and through the second spring 604, the cover plate 103 can be reset after being pulled.

[0085] The cutting assembly includes a mounting frame 201 fixed to the lower end of the grinding cylinder 101, and a mounting shaft 203 is rotatably connected between the mounting frame 201 and the grinding cylinder 101. A cutting blade 204 is detachably mounted on one end of the mounting shaft 203 located inside the grinding cylinder 101 through bolts. A first motor 202 for driving the mounting shaft 203 is mounted on the mounting frame 201, and a sliding hole is opened on the supporting plate 3, and the supporting plate 3 is slidably connected to the outer side of the mounting shaft 203 through the sliding hole; the cutting blade 204 on the mounting shaft 203 is driven to rotate by the first motor 202, and during the rotation of the cutting blade 204, the input material is cut and ground and accumulated on the supporting plate 3.

[0086] The lifting component includes a threaded tube 401 rotatably connected to the inside of the grinding cylinder 101, a threaded rod 402 is threadedly engaged with the threaded tube 401, the threaded rod 402 is fixed to the lower end of the supporting plate 3, and a second motor 403 for driving the threaded tube 401 is installed at the lower end of the grinding cylinder 101; the guiding component includes a sleeve 501 fixed to the inside of the grinding cylinder 101, a sliding rod 502 is slidably connected to the sleeve 501, and one end of the sliding rod 502 is fixed to the lower end of the supporting plate 3; the threaded tube 401 is driven to rotate by the second motor 403, and during the rotation of the threaded tube 401, the mutually engaged transmission between the threaded rod 402 and the threaded tube 401 and the sliding guiding effect of the sleeve 501 and the sliding rod 502 are used to make the supporting plate 3 perform lifting and lowering motion after being subjected to force.

[0087] The gel for treating gum atrophy and repairing oral mucosa is used in treating gum atrophy, repairing oral mucosa damage, treating oral ulcers, and relieving oral inflammation.

[0088] During the grinding process of the Chinese medicine raw material taken out from the liquid nitrogen by the grinding assembly, the cover plate 103 is pulled away from the grinding cylinder 101, so that a gap is generated between the cover plate 103 and the grinding cylinder 101. After the cover plate 103 is pulled, the Chinese medicine raw material taken out from the liquid nitrogen is put into the grinding cylinder 101 through the gap. After the putting is completed, the cover plate 103 is reset toward the inside of the grinding cylinder 101 by the elastic force of the second spring 604 on the connecting assembly.

[0089] During the process of the cover plate 103 being reset toward the inside of the grinding cylinder 101, the circular plate 803 at the front end of the piston rod 802 on each group of the inflation assembly is respectively abutted against each group of the push plate 806. During the abutment process, each group of the piston rod 802 is pushed to move toward the inside of each group of the piston cylinder 801. During the movement of the piston rod 802, part of the gas inside the piston cylinder 801 is squeezed and transported to the inside of the annular airbag 702 to inflate the inside of the annular airbag 702. During the inflation process, the annular airbag 702 expands under the action of pressure and is tightly abutted against the inner wall of the grinding cylinder 101, thereby sealing the inside of the grinding cylinder 101. Through the sealing effect, the material powder is prevented from being in a low temperature state during the grinding process, and is easily adsorbed with moisture in the air and agglomerated, and may fly under the action of the airflow generated by the grinding, thereby further ensuring the grinding effect of the Chinese medicine raw materials taken out from the liquid nitrogen.

[0090] After the cover plate 103 is covered and sealed, the cutting blade 204 on the mounting shaft 203 is driven to rotate by the first motor 202. During the rotation of the cutting blade 204, the input material is cut and ground and accumulated on the supporting plate 3. After the cutting and grinding process, the supporting plate 3 is lowered by the lifting assembly and the guiding action. The lowering of the supporting plate 3 allows the ground material to be discharged outward through the discharge port 102, thereby completing the grinding process of the Chinese medicine raw materials taken out from the liquid nitrogen.

[0091] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0092] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A gel for treating gingival atrophy and repairing oral mucosa, characterized in that: The invention comprises 40-60 parts of purified water, 15-30 parts of fish scale glue excipient, 10-25 parts of traditional Chinese medicine extract, 4-12 parts of sorbitol, 3-8 parts of preservative, 5-15 parts of surfactant, 0.01-0.05 parts of sodium alginate and 0.05-0.2 parts of chlorhexidine gluconate.

2. The gel for treating gingival atrophy and repairing oral mucosa according to claim 1, characterized in that: The traditional Chinese medicine extract comprises 60-200 parts of bletilla striata, 150-300 parts of angelica dahurica, 200-400 parts of white ampelopsis thunbergii and 5-30 parts of mint.

3. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 1, characterized in that: The following steps are involved: S1. Extracting fish scale glue to obtain fish scale glue solution; S2, preparation of Chinese medicine powder, immersing the Chinese medicine in liquid nitrogen for 1-5 minutes, quickly taking out the Chinese medicine from the liquid nitrogen, and grinding the Chinese medicine into powder particles of 200-300 meshes by a grinding component; S3, preparation of aqueous extract of Chinese medicine components, placing the Chinese medicine powder obtained in S2 in pure water according to a certain proportion, extracting at 60-100° C. for 30-90 min, filtering, and collecting the aqueous extract of Chinese medicine and Chinese medicine granules respectively; S4, preparation of the oil phase extract of the Chinese medicine component, placing the Chinese medicine particles collected in S3 in vegetable oil, extracting at 60-120° C. for 30-90 min, filtering, and collecting the Chinese medicine oil phase extract; S5. Preparation of a composition for treating gingival atrophy and repairing oral mucosa. Dissolve fish scale glue solution, sorbitol, sodium alginate, preservatives and chlorhexidine gluconate in pure water in the above proportions with stirring. After fully dissolved, add the aqueous extract and oil extract of traditional Chinese medicine. After mixing evenly, add a surfactant for emulsification at a speed of 3000-5000 r / min. Fully emulsify for 30-120 min to obtain a composition for treating gingival atrophy and repairing oral mucosa.

4. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 3, characterized in that: The grinding assembly comprises: A grinding cylinder (101), wherein the grinding cylinder (101) is provided with a material discharge port (102), a cover plate (103) for covering the interior of the grinding cylinder (101) is arranged above the grinding cylinder (101), a cutting assembly for grinding and cutting materials is arranged on the grinding cylinder (101), a carrying plate (3) for carrying the materials after cutting and grinding is arranged inside the grinding cylinder (101), the carrying plate (3) and the interior of the grinding cylinder (101) are arranged to match each other, a lifting assembly for lifting and lowering the carrying plate (3) and a guiding assembly for guiding during the lifting process are arranged on the grinding cylinder (101), a connecting assembly for assisting the connection of the cover plate (103) is arranged between the cover plate (103) and the grinding cylinder (101), and a sealing assembly for sealing the interior of the grinding cylinder (101) after covering is arranged on the cover plate (103); The sealing component comprises an annular groove (701) formed on the outside of the cover plate (103), an annular airbag (702) is installed inside the annular groove (701), and an inflation component for inflating the inside of the annular airbag (702) is provided between the cover plate (103) and the inside of the grinding cylinder (101).

5. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 4, characterized in that: The inflation component is provided with multiple groups, and the inflation component includes a piston cylinder (801) fixed to the lower end of the cover plate (103), one end of the piston cylinder (801) is arranged to communicate with the interior of the annular airbag (702), a piston rod (802) is slidably connected to the piston cylinder (801), a circular plate (803) is fixed to one end of the piston rod (802), a retaining ring (804) is fixed to the outer side of the piston cylinder (801), a first spring (805) is sleeved on the outer side of the piston cylinder (801), two ends of the first spring (805) are respectively connected to the retaining ring (804) and the circular plate (803), and a push plate (806) for resisting and transmitting with the circular plate (803) is fixed to the inside of the grinding cylinder (101).

6. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 5, characterized in that: The connection assembly comprises two groups of symmetrically arranged fixing plates (601) fixed to the outside of the cover plate (103); a T-shaped rod (602) is slidably connected to the fixing plate (601); a connecting plate (603) is fixed to one end of the T-shaped rod (602); the connecting plate (603) is fixed to the outside of the grinding cylinder (101); and a second spring (604) is sleeved on the outside of the T-shaped rod (602).

7. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 6, characterized in that: The cutting assembly comprises a mounting frame (201) fixed to the lower end of the grinding cylinder (101); a mounting shaft (203) is rotatably connected between the mounting frame (201) and the grinding cylinder (101); a cutting blade (204) is detachably mounted on one end of the mounting shaft (203) located inside the grinding cylinder (101) via a bolt; a first motor (202) for driving the mounting shaft (203) is mounted on the mounting frame (201); a sliding hole is provided on the bearing plate (3), and the bearing plate (3) is slidably connected to the outer side of the mounting shaft (203) via the sliding hole.

8. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 4, characterized in that: The lifting assembly comprises a threaded tube (401) rotatably connected to the inside of the grinding cylinder (101); a threaded rod (402) is threadedly engaged with the threaded tube (401); the threaded rod (402) is fixed to the lower end of the bearing plate (3); and a second motor (403) for driving the threaded tube (401) is installed at the lower end of the grinding cylinder (101).

9. The method for preparing the gel for treating gingival atrophy and repairing oral mucosa according to claim 8, characterized in that: The guide assembly comprises a sleeve (501) fixed inside the grinding cylinder (101), a sliding rod (502) is slidably connected to the sleeve (501), and one end of the sliding rod (502) is fixed to the lower end of the bearing plate (3).

10. Use of the gel for treating gingival atrophy and repairing oral mucosa according to claims 1-2 in treating gingival atrophy, repairing oral mucosal damage, treating oral ulcers, and relieving oral inflammation.

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