Traditional Chinese medicine composition for treating vertigo as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating dizziness and a preparation method and application thereof. Relates to the field of traditional Chinese medicine preparations. The traditional Chinese medicine composition comprises the following components: prepared rehmannia root; salted eucommia ulmoides; parasitic loranthus; gastrodia elata; uncaria rhynchophylla; a keel; radix salviae miltiorrhizae; radix astragali; mulberry; fructus lycii; radix achyranthis bidentatae; honey-fried licorice root. According to the traditional Chinese medicine composition disclosed by the invention, two treatment methods of tonifying liver and kidney and relieving dizziness and dredging collaterals are creatively combined and applied, one is to nourish liver and kidney, replenish essence and benefit marrow, and moisten brain collaterals; on one hand, disordered blood and qi are guided to move downwards, and Qi of the clear yang is flourishing and lifted simultaneously, so that disordered and unsmooth Qi and blood are smooth due to the disordered and unsmooth Qi and blood, and wind is extinguished. All the medicines are used together to achieve the effects of tonifying liver and kidney, extinguishing wind and dredging collaterals.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine preparations, and in particular to a Chinese medicine composition for treating vertigo, and a preparation method and application thereof. Background Art

[0002] Vertigo is a common disease with complex clinical manifestations, mainly manifested by spatial orientation disorders in patients, accompanied by obvious symptoms such as self-or external rotation, lightheadedness, and instability. Modern medical research shows that vertigo is a multidisciplinary disease involving the vestibular system, internal medicine, neurology, and mental health. Due to the diversity of vertigo symptoms and the fact that patients' descriptions of symptoms are often not accurate, diagnosis is difficult. Although auxiliary examinations can provide certain evidence for the diagnosis of vertigo, direct evidence for diagnosis is often lacking. Therefore, the diagnosis and treatment of vertigo have always been challenging.

[0003] From the perspective of etiology, the pathogenesis of vertigo is quite complex. The conventional method of Western medicine for treating vertigo mainly relies on symptomatic treatment. Commonly used drugs include betahistine, scopolamine, lidocaine, metoclopramide and oryzanol. As a commonly used drug for the treatment of vertigo, betahistine has the effect of dilating capillaries and improving microcirculation. It can effectively increase cerebral blood flow and inner ear blood flow, thereby relieving inner ear vertigo, tinnitus and ear occlusion. It also has the effect of inhibiting histamine release and anti-allergic. Anisodamine plays a therapeutic role by relieving microvascular spasm. Lidocaine, as a nerve blocker, can inhibit local pathological reactions, thereby playing an anti-vertigo effect. Metoclopramide, as a central antiemetic, has a significant therapeutic effect on nausea and vomiting caused by various reasons, and has a sedative effect. Oryzanol further improves the symptoms of vertigo by regulating autonomic nervous function.

[0004] Although Western medicine can relieve vertigo symptoms in the short term, it is often unable to fundamentally cure vertigo, and long-term use may lead to a weakening of the patient's central vestibular compensation ability, and may even produce adverse reactions, affecting long-term efficacy. Therefore, when treating vertigo, Western medicine relies more on symptomatic support and lacks a complete cure.

[0005] Unlike symptomatic treatment in Western medicine, TCM has a history of thousands of years in treating vertigo. TCM emphasizes syndrome differentiation and treatment, and focuses on regulating the body's qi, blood, yin and yang as a whole. It believes that vertigo is caused by a variety of reasons, such as imbalance of yin and yang in the body, poor circulation of qi and blood, and dysfunction of internal organs. TCM theory believes that the occurrence of vertigo is closely related to pathological factors such as liver and kidney deficiency, spleen and stomach weakness, and phlegm and dampness obstruction. In clinical practice, TCM can effectively improve vertigo symptoms and relieve patients' discomfort by regulating liver and kidney function, removing dampness and phlegm, and promoting blood circulation and removing blood stasis.

[0006] As early as the time of the Neijing, the theory of vertigo had been initially discussed. The Lingshu Hailun pointed out that "if the marrow sea is insufficient, the brain will spin, the ears will tinnitus will occur, the legs will be sore and dizzy, the eyes will be unable to see, and the person will be lazy and sleepy", indicating that kidney essence deficiency and marrow sea deficiency are closely related to the occurrence of vertigo. The Suwen Shanggu Tianzhen Lun also mentioned "kidney qi decline" and pointed out that the middle-aged and elderly people are particularly prone to such problems. Vertigo caused by liver and kidney deficiency is more common in the middle-aged and elderly people. Its pathogenesis includes hyperactivity of liver yang, internal wind disturbing the clear orifices, or kidney essence deficiency, which causes the essence to fail to produce marrow, leading to malnutrition of brain vessels and poor blood circulation, thus causing vertigo.

[0007] The principle of TCM treatment of vertigo caused by liver and kidney deficiency is to first nourish the liver and kidney, restore liver and kidney function, replenish essence and marrow, and nourish the brain. Secondly, it is necessary to calm the liver and extinguish wind, regulate qi and blood, promote blood circulation, further dredge the brain and relieve the symptoms of vertigo caused by internal wind. This "root deficiency and superficial excess" treatment method can not only treat the root cause of vertigo, but also relieve the patient's clinical manifestations. Li Yongcui mentioned in "Zhengzhi Huibu·Shangqiaomen·Vertigo" that the treatment of vertigo should be adjusted according to different deficiency and excess conditions, emphasizing that "yang wants to escape, yin absorbs it", that is, during treatment, attention should be paid to the retrograde flow of qi and blood caused by kidney deficiency, combined with the regulation of liver and kidney, to promote the smooth flow of qi and blood, and the wind will be calmed.

[0008] At present, most of the Chinese medicine combinations used in the clinical treatment of vertigo focus on promoting blood circulation and removing blood stasis, improving microcirculation, such as Xiangdan injection and Shuxuetong injection, which are suitable for patients with vertigo caused by severe blood stasis; or focus on drying dampness and removing phlegm, such as containing tangerine peel, pinellia, white atractylodes, and gall bladder arisaema, which are suitable for patients with phlegm and dampness; there are also some drugs that focus on warming yang and dispersing cold, such as containing roasted aconite, cinnamon twig, and dried ginger, which are suitable for patients with yang deficiency and cold stagnation. If the patient also has numbness of limbs or head and face, blurred vision, insomnia and forgetfulness, tinnitus, sore waist and weak knees, it is vertigo caused by liver and kidney deficiency. As early as in the "Inner Canon of Medicine", there was a relatively detailed discussion on vertigo caused by liver and kidney deficiency. For example, "Lingshu·Hai Lun" said that "if the marrow sea is insufficient, the brain will turn and the ears will tinnitus, the shins will be sore and dizzy, the eyes will see nothing, and you will be lazy and sleep." This shows that vertigo is closely related to kidney essence deficiency and marrow sea deficiency. Dizziness caused by liver and kidney deficiency is more common in middle-aged and elderly people. "Suwen·Ancient Innocence" states that "at the age of fifty-eight, kidney qi declines", "at the age of forty, yin qi is halved", and "Lingshu·Tiannian Pian" states that "at the age of fifty, liver qi begins to decline". Li Yongcui also pointed out in "Zhengzhi Huibu·Shangqiaomen·Xianyun": "The yin and yang of the human body embrace each other and do not leave each other, so the yang wants to escape, and the yin absorbs it. If there are excessive sexual dreams, the kidneys cannot receive qi and return to the origin, causing all qi to rush upward. This dizziness is caused by kidney deficiency." Liver and kidney deficiency, on the one hand, leads to hyperactivity of liver yang, which transforms into internal wind, and the internal wind disturbs the clear orifices and causes dizziness; on the other hand, kidney essence is depleted, the essence cannot produce marrow, the marrow sea is insufficient, the brain meridians are not nourished, and dizziness occurs; on the other hand, the brain meridians are not nourished and become weak, and the atrophy causes blood stagnation in the meridians, and the brain meridians are blocked, which makes dizziness difficult to cure.

[0009] It can be seen that vertigo is mostly caused by liver and kidney deficiency, and blood stasis blocking the collaterals is the symptom. It is a disease with both deficiency and excess. The treatment of liver and kidney deficiency type vertigo should be based on nourishing the liver and kidneys, while remembering to calm the liver and extinguish wind, and activating blood circulation and unblocking collaterals, rather than simply focusing on removing blood stasis and phlegm or warming yang and tonifying deficiency. Summary of the invention

[0010] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating vertigo caused by liver and kidney deficiency and blood stasis.

[0011] The first aspect of the present invention is:

[0012] Provided is a Chinese medicine composition.

[0013] The second aspect of the present invention is:

[0014] Provided is a method for preparing a traditional Chinese medicine composition.

[0015] The third aspect of the present invention is:

[0016] Application of the Chinese medicine composition.

[0017] The invention also provides a capsule for treating vertigo.

[0018] The invention also provides an oral liquid for treating vertigo.

[0019] Specifically, the technical solution adopted according to the first aspect of the present invention is:

[0020] A Chinese medicine composition comprising the following components:

[0021] Rehmannia root;

[0022] Salt Eucommia;

[0023] mulberry;

[0024] Gastrodia elata;

[0025] Uncaria rhynchophylla;

[0026] keel;

[0027] Salvia miltiorrhiza;

[0028] Astragalus;

[0029] mulberry;

[0030] wolfberry;

[0031] Achyranthes bidentata;

[0032] Roasted licorice.

[0033] According to the embodiments of the present invention, one of the technical solutions has at least one of the following advantages or beneficial effects:

[0034] The Chinese medicine composition of the present invention creatively combines the two treatment methods of tonifying the liver and kidney and extinguishing wind and unblocking the meridians, one to nourish the liver and kidney, replenish the essence and marrow, and nourish the brain meridians; the other to guide the disordered blood and qi downward, and carry the clear yang qi upward, and ascend and descend at the same time, so that the disordered qi and blood can be smooth, and the wind can be calmed. The combination of the medicines can play the effect of tonifying the liver and kidney, extinguishing wind and unblocking the meridians.

[0035] The Chinese medicine composition of the present invention comprises the following: Radix Rehmanniae Preparata and Fructus Lycii nourish the liver and kidney and are the main medicines; Fructus Mori, Herba Mori Parasitici and Eucommia Salviae Miltiorrhizae assist the main medicines in nourishing the liver and kidney and are the ministers; Gastrodia elata and Rhizoma Uncariae soothe the liver and relieve wind, Astragalus and Salvia miltiorrhiza invigorate qi, activate blood circulation and dredge collaterals, Bone Dragon soothes the liver and suppresses yang, Achyranthes bidentata nourishes the liver and kidney and activates blood circulation and are the adjuvants; Radix Glycyrrhizae Harmonizes the various medicines and is the guiding medicine.

[0036] In the prescription, Astragalus membranaceus can "tonify the five internal organs". First, it is combined with Salvia miltiorrhiza to achieve the effect of invigorating Qi and activating blood circulation. Second, because the location of vertigo is in the head, it has an ascending effect, which can lead the medicine upward and directly reach the affected area. Third, this disease is mainly caused by liver and kidney deficiency. If there is no ascending medicine, the clear Qi will be difficult to ascend, the brain marrow will be malnourished and the vertigo will be difficult to eliminate. Fourth, it is combined with descending medicines such as dragon bone and Achyranthes bidentata to make the clear rise and the turbid fall. The above medicines have the effect of calming the liver and calming wind, invigorating Qi, activating blood circulation and unblocking collaterals.

[0037] The Chinese medicine composition of the present invention comprises Rehmannia glutinosa, which is sweet and slightly warm, enters the liver and kidney meridians, nourishes blood and yin, and replenishes essence and fills marrow. It is the tuberous root of Rehmannia glutinosa, a plant of Scrophulariaceae, which is processed and steamed. Take the dried Rehmannia glutinosa, add 30% yellow wine, shake and mix, put it in a slicing machine, steam until the inside and outside are black and moist, take it out and dry it in the sun. Alternatively, take the dried Rehmannia glutinosa, put it in a steamer and steam it for 8 hours, simmer it overnight, turn it over the next day, steam it for 4-8 hours, simmer it overnight, take it out, dry it until it is 80% dry, slice it, and then dry it in the sun.

[0038] The Chinese medicine composition of the present invention comprises wolfberry, which is sweet and mild in nature, and enters the liver and kidney meridians to nourish the liver and kidney. The product is the mature fruit of wolfberry or Lycium barbarum of the Solanaceae family. The fruit is picked when it is ripe in summer and autumn, the fruit stalk is removed, and the fruit is placed in a cool place to dry until the skin is wrinkled, and then exposed to the sun until the skin is dry and hard and the flesh is soft. In case of rain, it can be dried with a low fire.

[0039] The Chinese medicine composition of the present invention comprises the herb Mulberry, which is bitter, sweet and flat, enters the liver and kidney meridians, nourishes the liver and kidneys, and strengthens the tendons and bones. The herb Mulberry is a dried leafy stem of the plant of the family Loranthaceae. The herb is harvested from winter to the next spring, the thick stems are removed, the herb is cut into sections, and dried, or steamed and then dried.

[0040] The Chinese medicine composition of the invention comprises mulberries, which are sweet, sour and cold, enter the heart, liver and kidney meridians, nourish yin and blood, promote the production of body fluid and relieve dryness, and are the fruits of the plant of the genus Morus of the Moraceae family.

[0041] The Chinese medicine composition of the present invention comprises the bark of Eucommia ulmoides, which is sweet and warm, enters the liver and kidney meridians, nourishes the liver and kidney, and strengthens the tendons and bones. The bark is selected from plants grown for more than 15 to 20 years between Qingming and Summer Solstice, and the bark is peeled off according to the size of the medicinal material, the rough skin is removed, and the herbs are dried in the sun. After being roasted with salt, the herbs can be led into the kidneys and directly reach the lower part of the body, which is warm but not dry, and has enhanced effects of nourishing the liver and kidneys and strengthening the tendons and bones.

[0042] The Chinese medicine composition of the present invention comprises the dried rhizome of the orchid plant Gastrodia elata, which is sweet and flat in taste, enters the liver meridian, can calm wind and stop spasms, calm liver yang, dispel wind and dredge meridians.

[0043] The Chinese medicine composition of the present invention comprises the dried root and rhizome of the plant Salvia miltiorrhiza of the Lamiaceae family, which is bitter, slightly cold, red in color, enters the heart, pericardium and liver meridians, activates blood circulation and removes blood stasis, cools blood and soothes the mind.

[0044] The Chinese medicine composition of the present invention comprises the following: the astragalus root is sweet, warm, can invigorate qi and strengthen the exterior, has the effects of promoting diuresis and removing toxins, draining pus, and healing sores and promoting tissue regeneration. The astragalus root is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus.

[0045] The Chinese medicine composition of the present invention has dragon bone in the prescription, which is sweet, astringent and mild, and enters the heart, liver and kidney meridians, calms the nerves and calms the liver and suppresses yang. It is the fossil of bones of ancient large mammals such as elephants, three-toed horses, rhinos, deer, cattle and the like.

[0046] The Chinese medicine composition of the present invention has the dried root of Achyranthes bidentata, a plant of the Amaranthaceae family, which is bitter, sweet, sour and flat, and enters the liver and kidney meridians, removes blood stasis and promotes menstruation, nourishes the liver and kidneys, strengthens tendons and bones, and guides blood downward.

[0047] The Chinese medicine composition of the present invention comprises the roasted licorice root, a leguminous plant, and the roasted licorice root is licorice roasted with honey. The honey is put into a pot and refined into medium honey. Raw licorice slices are added with a slow fire and stir-fried evenly. The mixture is taken out of the pot after 3 to 5 minutes and placed in a baking room or oven to be baked until it is no longer sticky. The mixture is then taken out and cooled.

[0048] The Chinese medicine composition of the present invention can not only treat dizziness caused by liver and kidney deficiency and blood stasis blocking the collaterals, but also treat tinnitus, deafness, soreness of waist and knees, numbness of head, face or limbs, insomnia and forgetfulness caused by liver and kidney deficiency and blood stasis blocking the collaterals.

[0049] According to one embodiment of the present invention, the Chinese medicine composition comprises the following components in parts by weight:

[0050] Rehmannia root, 2-3 parts;

[0051] Salt Eucommia, 2-2.5 parts;

[0052] Mulberry parasite, 2-3 parts;

[0053] Gastrodia elata, 2-2.5 parts;

[0054] Uncaria rhynchophylla, 2-2.5 parts;

[0055] Dragon bones, 3-6 parts;

[0056] Salvia miltiorrhiza, 3-4 parts;

[0057] Astragalus, 4-6 parts;

[0058] Mulberry, 2-3 servings;

[0059] Wolfberry, 2-3 servings;

[0060] Achyranthes bidentata, 2-2.5 parts;

[0061] Roasted licorice, 0.6-1.2 parts.

[0062] According to one embodiment of the present invention, preferably, the Chinese medicine composition comprises the following components in parts by weight:

[0063] 3 parts of Rehmannia root;

[0064] 2 parts of salted Eucommia ulmoides;

[0065] 2 parts of mistletoe;

[0066] 2 parts of Gastrodia elata;

[0067] 2 parts of Uncaria rhynchophylla;

[0068] 6 parts of dragon bones;

[0069] 3 parts of Salvia miltiorrhiza;

[0070] 4 parts of Astragalus;

[0071] 2 portions of mulberry;

[0072] 2 portions of wolfberry;

[0073] 2 portions of Achyranthes bidentata;

[0074] 1 portion of roasted licorice root.

[0075] According to an embodiment of the present invention, the dragon bone is a dragon bone that has been decocted in water. The decocting method can ensure that the effective ingredients (especially minerals) in the dragon bone are released to the greatest extent.

[0076] Specifically, the technical solution adopted according to the second aspect of the present invention is:

[0077] A method for preparing the Chinese medicine composition comprises the following steps:

[0078] The Chinese medicine composition is obtained by mixing Rehmannia root, wolfberry fruit, mulberry, parasitic herb, Eucommia barbata, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted liquorice.

[0079] According to one embodiment of the present invention, the Chinese medicine composition is a granule Chinese medicine composition, and the preparation method of the granule Chinese medicine composition comprises the following steps:

[0080] Mix Rehmannia root, wolfberry, mulberry, parasitic herb, Eucommia barbata, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula officinalis and roasted Licorice root, add water and boil, filter and obtain a filtrate;

[0081] The filtrate is taken and concentrated under reduced pressure to obtain a clear paste;

[0082] Adding part of maltodextrin to the clear paste, spray drying, and obtaining dry extract powder;

[0083] The remaining amount of maltodextrin is added to the dry extract powder, and the mixture is subjected to dry pressing and granulation to obtain the granular Chinese medicine composition.

[0084] According to one embodiment of the present invention, the decocting with water is performed twice, and each decocting is 1-1.5 hours.

[0085] According to one embodiment of the present invention, in the secondary decoction, the amount of water added each time is 8 times the total weight of Rehmannia root, wolfberry fruit, mulberry, viburnum, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and roasted liquorice.

[0086] According to one embodiment of the present invention, the reduced pressure concentration treatment comprises the following steps: at 60-65° C., the filtrate is concentrated under reduced pressure to a clear paste with a relative density of 1.05-1.10.

[0087] According to one embodiment of the present invention, during the spray drying process, the air inlet temperature is 175±5°C.

[0088] According to one embodiment of the present invention, during the spray drying, the air outlet temperature is 90±5°C.

[0089] According to one embodiment of the present invention, the dry pressing granulation comprises the following steps: adding excess maltodextrin to the dry extract powder to obtain a mixed dry extract powder, granulating with an 18-20 mesh sieve under the conditions of a roller speed of 20 to 30 Hz, a feed screw speed of 20 to 30 Hz, and an extrusion pressure of 5 to 7 bar, collecting 10 to 65 mesh granules, and drying to a granule moisture content of ≤6.0%.

[0090] Another aspect of the present invention provides a capsule for treating vertigo, including the Chinese medicine composition as described in the first embodiment. Since the application adopts all the technical solutions of the Chinese medicine composition, it has at least all the beneficial effects brought by the technical solutions of the above embodiment.

[0091] According to one embodiment of the present invention, the preparation method of the capsule for treating vertigo comprises the following steps: mixing Rehmannia root, wolfberry, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and Glycyrrhiza uralensis to obtain a mixture; taking the mixture, decocting it twice, adding 8-10 times the amount of water each time, decocting it for 1-2 hours, filtering it through a 200-mesh sieve, combining the secondary filtrates and setting them aside; taking the filtrate, concentrating it under reduced pressure at 60-65°C to a clear paste with a relative density of 1.05-1.10, filtering it through a 100-mesh sieve, checking the clear paste, and setting it aside after it passes the test; taking the above-mentioned clear paste, adding starch, drying it at low temperature and then putting it into capsules to obtain the capsule for treating vertigo.

[0092] Another aspect of the present invention also provides an oral liquid for treating vertigo, including the Chinese medicine composition as described in the first embodiment. Since the application adopts all the technical solutions of the Chinese medicine composition, it has at least all the beneficial effects brought by the technical solutions of the above embodiment.

[0093] According to one embodiment of the present invention, the preparation method of the oral liquid for treating vertigo comprises the following steps: mixing Rehmannia root, wolfberry, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and roasted liquorice to obtain a mixture; taking the mixture, decocting it twice, adding 8-10 times the amount of water each time, decocting it for 1-2 hours, filtering it through a 200-mesh sieve, combining the secondary filtrates and setting them aside; taking the filtrate, centrifuging it, concentrating it, bottling it, sealing it and sterilizing it to obtain the oral liquid for treating vertigo.

[0094] According to one embodiment of the present invention, the present invention also provides a tablet for treating vertigo. The preparation method of the tablet for treating vertigo comprises the following steps: mixing Rehmannia root, wolfberry, mulberry, mistletoe, salt eucommia, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and roasted liquorice to obtain a mixture; taking the mixture, decocting it twice, adding 8-10 times the amount of water each time, decocting it for 1-2 hours, filtering it through a 200-mesh sieve, combining the secondary filtrates and setting them aside; taking the filtrate, concentrating it under reduced pressure at 60-65°C to a clear paste with a relative density of 1.05-1.10, filtering it through a 100-mesh sieve, checking the clear paste, and setting it aside after it is qualified; taking the above-mentioned clear paste, adding maltodextrin, mixing it evenly, granulating it, and tableting it to obtain the tablet for treating vertigo.

[0095] According to one embodiment of the present invention, the present invention also provides a pill for treating vertigo. The preparation method of the pill for treating vertigo comprises the following steps: mixing Rehmannia root, wolfberry, mulberry, mistletoe, salt Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and roasted liquorice to obtain a mixture; taking the above mixture, decocting it twice, adding 8-10 times the amount of water each time, decocting it for 1-2 hours, filtering it through a 200-mesh sieve, combining the secondary filtrates and setting them aside; taking the filtrate, concentrating it under reduced pressure at 60-65°C to a clear paste with a relative density of 1.05-1.10, filtering it through a 100-mesh sieve, checking the clear paste, and setting it aside after it is qualified; taking the above clear paste, adding maltodextrin, mixing it evenly, making it into strips, and forming it into pills to obtain the pills for treating vertigo.

[0096] Additional aspects and advantages of the present invention will be set forth in part in the description which follows and, in part, will be obvious from the description which follows, or may be learned by practice of the present invention. DETAILED DESCRIPTION

[0097] The words "preferred", "more preferred" and the like in the present invention refer to embodiments of the present invention that can provide certain beneficial effects in certain circumstances. However, other embodiments may also be preferred under the same circumstances or other circumstances. In addition, the description of one or more preferred embodiments does not imply that other embodiments are not applicable, nor is it intended to exclude other embodiments from the scope of the present invention.

[0098] When a numerical range is disclosed herein, the above range is considered to be continuous and includes the minimum and maximum values ​​of the range, as well as every value between such minimum and maximum values. Further, when a range refers to an integer, every integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be combined. In other words, unless otherwise indicated, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0099] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of the present invention.

[0100] Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0101] Example 1

[0102] A Chinese medicine composition comprising the following components in parts by weight:

[0103] 3 parts of Rehmannia root;

[0104] 2 parts of salted Eucommia ulmoides;

[0105] 2 parts of mistletoe;

[0106] 2 parts of Gastrodia elata;

[0107] 2 parts of Uncaria rhynchophylla;

[0108] 6 portions of dragon bones (fried first);

[0109] 3 parts of Salvia miltiorrhiza;

[0110] 4 parts of Astragalus;

[0111] 2 portions of mulberry;

[0112] 2 portions of wolfberry;

[0113] 2 portions of Achyranthes bidentata;

[0114] 1 portion of roasted licorice root.

[0115] A granular Chinese medicine composition, and a preparation method thereof, comprising the following steps:

[0116] Mix Rehmannia root, wolfberry, mulberry, parasitic herb, Eucommia barbata, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Achyranthes bidentata and Glycyrrhiza uralensis, add water and decoct twice, add 8 times of water each time, decoct for 1 hour and then filter through a 200-mesh sieve, combine the two filtrates to obtain a filtrate;

[0117] The filtrate was taken and concentrated under reduced pressure at 60° C. to a clear paste with a relative density of 1.05-1.10, and filtered through a 100-mesh sieve for later use;

[0118] Add maltodextrin to the clear paste, spray dry, control the air inlet temperature to 175±5°C, and the air outlet temperature to 90±5°C, to obtain dry extract powder;

[0119] Add maltodextrin to the dry extract powder, pass through an 80-mesh sieve, mix well to obtain a mixed dry extract powder, granulate with an 18-20 mesh sieve under the conditions of a roller speed of 200 Hz, a feed screw speed of 20 Hz, and an extrusion pressure of 5 bar, collect 10-65 mesh granules, and dry until the granule moisture content is ≤6.0% to obtain the granule Chinese medicine composition.

[0120] The above granular Chinese medicine composition was taken and packaged with polyester / aluminum / polyethylene medicinal composite film, 8 g per bag, to obtain a granular finished product.

[0121] Example 2

[0122] Embodiment 2 is the powder prescription of Chinese medicine composition.

[0123] Specific:

[0124] A Chinese medicine composition comprising the following components in parts by weight:

[0125] 3 parts of Rehmannia root;

[0126] 2 parts of salted Eucommia ulmoides;

[0127] 2 parts of mistletoe;

[0128] 2 parts of Gastrodia elata;

[0129] 2 parts of Uncaria rhynchophylla;

[0130] 6 portions of dragon bones (fried first);

[0131] 3 parts of Salvia miltiorrhiza;

[0132] 4 parts of Astragalus;

[0133] 2 portions of mulberry;

[0134] 2 portions of wolfberry;

[0135] 2 portions of Achyranthes bidentata;

[0136] 1 portion of roasted licorice root.

[0137] A powder prescription of a Chinese medicine composition, the preparation method comprising the following steps:

[0138] Prepared rehmannia root, wolfberry fruit, mulberry, parasitic herb, salt eucommia bark, gastrodia elata, Uncaria rhynchophylla, astragalus, salvia miltiorrhiza, dragon bone, Achyranthes bidentata and roasted liquorice are mixed, dried, crushed, mixed evenly, sterilized and packaged to obtain a powder formula of the traditional Chinese medicine composition.

[0139] Example 3

[0140] Example 3 is a tablet formula of the Chinese medicine composition.

[0141] Specific:

[0142] A Chinese medicine composition comprising the following components in parts by weight:

[0143] 3 parts of Rehmannia root;

[0144] 2 parts of salted Eucommia ulmoides;

[0145] 2 parts of mistletoe;

[0146] 2 parts of Gastrodia elata;

[0147] 2 parts of Uncaria rhynchophylla;

[0148] 6 portions of dragon bones (fried first);

[0149] 3 parts of Salvia miltiorrhiza;

[0150] 4 parts of Astragalus;

[0151] 2 portions of mulberry;

[0152] 2 portions of wolfberry;

[0153] 2 portions of Achyranthes bidentata;

[0154] 1 portion of roasted licorice root.

[0155] A tablet formulation of a Chinese medicine composition, the preparation method comprising the following steps:

[0156] Mixing Rehmannia root, wolfberry fruit, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted Licorice root to obtain a mixture;

[0157] Take the mixture, decoct it twice, add 8 times the amount of water each time, decoct for 1 hour, filter through a 200-mesh sieve, combine the two filtrates and set aside;

[0158] Take the filtrate, concentrate it under reduced pressure at 60℃ to a clear paste with a relative density of 1.05-1.10, filter it through a 100-mesh sieve, check the clear paste, and keep it for later use if it is qualified;

[0159] Take the above-mentioned clear paste, add maltodextrin, mix well, granulate and tablet, and obtain the tablet for treating vertigo.

[0160] Example 4

[0161] Embodiment 4 is the pill prescription of Chinese medicine composition.

[0162] Specific:

[0163] A Chinese medicine composition comprising the following components in parts by weight:

[0164] 3 parts of Rehmannia root;

[0165] 2 parts of salted Eucommia ulmoides;

[0166] 2 parts of mistletoe;

[0167] 2 parts of Gastrodia elata;

[0168] 2 parts of Uncaria rhynchophylla;

[0169] 6 portions of dragon bones (fried first);

[0170] 3 parts of Salvia miltiorrhiza;

[0171] 4 parts of Astragalus;

[0172] 2 portions of mulberry;

[0173] 2 portions of wolfberry;

[0174] 2 portions of Achyranthes bidentata;

[0175] 1 portion of roasted licorice root.

[0176] A pill prescription of a Chinese medicine composition, the preparation method comprising the following steps:

[0177] Mixing Rehmannia root, wolfberry fruit, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted Licorice root to obtain a mixture;

[0178] Take the above mixture, decoct it twice, add 8 times the amount of water each time, decoct for 1 hour, filter through a 200-mesh sieve, combine the two filtrates and set aside;

[0179] Take the filtrate, concentrate it under reduced pressure at 60℃ to a clear paste with a relative density of 1.05-1.10, filter it through a 100-mesh sieve, check the clear paste, and keep it for later use if it is qualified;

[0180] Take the above-mentioned clear paste, add maltodextrin, mix well, make into strips, and make into pills to obtain the pills for treating vertigo.

[0181] Example 5

[0182] Example 5 is an oral liquid prescription of the Chinese medicine composition.

[0183] Specific:

[0184] A Chinese medicine composition comprising the following components in parts by weight:

[0185] 3 parts of Rehmannia root;

[0186] 2 parts of salted Eucommia ulmoides;

[0187] 2 parts of mistletoe;

[0188] 2 parts of Gastrodia elata;

[0189] 2 parts of Uncaria rhynchophylla;

[0190] 6 portions of dragon bones (fried first);

[0191] 3 parts of Salvia miltiorrhiza;

[0192] 4 parts of Astragalus;

[0193] 2 portions of mulberry;

[0194] 2 portions of wolfberry;

[0195] 2 portions of Achyranthes bidentata;

[0196] 1 portion of roasted licorice root.

[0197] An oral liquid prescription of a Chinese medicine composition, the preparation method comprising the following steps:

[0198] Mixing Rehmannia root, wolfberry fruit, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted Licorice root to obtain a mixture;

[0199] Take the above mixture, decoct it twice, add 8 times the amount of water each time, decoct for 1 hour, filter through a 200-mesh sieve, combine the two filtrates and set aside;

[0200] The filtrate is centrifuged, concentrated, bottled, sealed, and sterilized to obtain the oral liquid for treating vertigo.

[0201] Example 6

[0202] Example 6 is a capsule recipe of the Chinese medicine composition.

[0203] Specific:

[0204] A Chinese medicine composition comprising the following components in parts by weight:

[0205] 3 parts of Rehmannia root;

[0206] 2 parts of salted Eucommia ulmoides;

[0207] 2 parts of mistletoe;

[0208] 2 parts of Gastrodia elata;

[0209] 2 parts of Uncaria rhynchophylla;

[0210] 6 portions of dragon bones (fried first);

[0211] 3 parts of Salvia miltiorrhiza;

[0212] 4 parts of Astragalus;

[0213] 2 portions of mulberry;

[0214] 2 portions of wolfberry;

[0215] 2 portions of Achyranthes bidentata;

[0216] 1 portion of roasted licorice root.

[0217] A capsule prescription of a Chinese medicine composition, the preparation method comprising the following steps:

[0218] Mixing Rehmannia root, wolfberry fruit, mulberry, mistletoe, Eucommia bark, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted Licorice root to obtain a mixture;

[0219] Take the above mixture, decoct it twice, add 8 times the amount of water each time, decoct for 1 hour, filter through a 200-mesh sieve, combine the two filtrates and set aside;

[0220] Take the filtrate, concentrate it under reduced pressure at 60℃ to a clear paste with a relative density of 1.05-1.10, filter it through a 100-mesh sieve, check the clear paste, and keep it for later use if it is qualified;

[0221] The above-mentioned clear paste is taken, starch is added, low-temperature dried and then filled into capsules to obtain the capsules for treating vertigo.

[0222] Performance Test:

[0223] The present invention selected 120 patients with vertigo to carry out clinical observation on the efficacy of the drug of the present invention, so as to make a scientific evaluation on the effectiveness of the drug of the present invention.

[0224] The granules in Example 1 (8 g per package, 17.22 g of slices) were used for clinical experiments, and the usage was as follows: 120 patients took the decoction of the example, 2 times a day, 1 package each time. The medication was continued for 7-14 days. Symptom changes and adverse reactions before and after treatment were observed, and the observation time was from before the start of medication to the end of medication.

[0225] Vertigo efficacy determination criteria: The clinical efficacy of the two groups was evaluated with reference to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes".

[0226] Cure: Clinical symptoms and signs disappear and do not recur during the follow-up period, and the TCM syndrome score decreases by ≥90%.

[0227] Markedly effective: The degree and duration of vertigo were significantly improved, other clinical symptoms and signs basically disappeared, and the number of attacks during the follow-up period decreased by >50% compared with before treatment, and the TCM syndrome score decreased by 70% to <90%.

[0228] Effective: The degree of vertigo is alleviated, the duration is shortened, other clinical symptoms and signs disappear, and the number of attacks during follow-up is reduced by 20% to 50% compared with before treatment, and the TCM syndrome score is reduced by 30% to <70%.

[0229] Ineffective: There is no significant change in clinical symptoms and signs or they may even get worse, and the TCM syndrome score decreases by less than 30%.

[0230] After the treatment of 120 patients, among the patients who took the medicine of Example 1, 39 cases were markedly effective, 77 cases were effective, 4 cases were ineffective, and the total effective rate was 96.67%. It shows that the Chinese medicine composition of the present invention can be used to treat dizziness caused by liver and kidney deficiency and blood stasis.

[0231] The above are only embodiments of the present invention, and are not intended to limit the patent scope of the present invention. Any equivalent transformations made using the contents of the present invention specification, or directly or indirectly applied in related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: Includes the following components: Rehmannia root; Salt Eucommia; mulberry; Gastrodia elata; Uncaria rhynchophylla; keel; Salvia miltiorrhiza; Astragalus; mulberry; wolfberry; Achyranthes bidentata; Roasted licorice.

2. A Chinese medicine composition according to claim 1, characterized in that: The composition comprises the following components in parts by weight: Rehmannia root, 2-3 parts; Salt Eucommia, 2-2.5 parts; Mulberry parasite, 2-3 parts; Gastrodia elata, 2-2.5 parts; Uncaria rhynchophylla, 2-2.5 parts; Dragon bones, 3-6 parts; Salvia miltiorrhiza, 3-4 parts; Astragalus, 4-6 parts; Mulberry, 2-3 servings; Wolfberry, 2-3 servings; Achyranthes bidentata, 2-2.5 parts; Roasted licorice, 0.6-1.2 parts.

3. A Chinese medicine composition according to claim 1, characterized in that: The composition comprises the following components in parts by weight: 3 parts of Rehmannia root; 2 parts of salted Eucommia ulmoides; 2 parts of mistletoe; 2 parts of Gastrodia elata; 2 parts of Uncaria rhynchophylla; 6 parts of dragon bones; 3 parts of Salvia miltiorrhiza; 4 parts of Astragalus; 2 portions of mulberry; 2 portions of wolfberry; 2 portions of Achyranthes bidentata; 1 portion of roasted licorice root.

4. A Chinese medicine composition according to claim 1, characterized in that: The dragon bones are the ones that have been boiled in water.

5. A method for preparing a Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: The Chinese medicine composition is obtained by mixing Rehmannia root, wolfberry fruit, mulberry, parasitic herb, Eucommia ulmoides, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula and roasted liquorice.

6. The method according to claim 5, characterized in that: The Chinese medicine composition is a granule Chinese medicine composition, and the preparation method of the granule Chinese medicine composition comprises the following steps: Mix Rehmannia root, wolfberry, mulberry, parasitic herb, Eucommia barbata, Gastrodia elata, Uncaria rhynchophylla, Astragalus membranaceus, Salvia miltiorrhiza, Dragon bone, Cyathula officinalis and roasted Licorice root, add water and boil, filter and obtain a filtrate; The filtrate is taken and concentrated under reduced pressure to obtain a clear paste; Adding part of maltodextrin to the clear paste, spray drying, and obtaining dry extract powder; The remaining amount of maltodextrin is added to the dry extract powder, and the mixture is subjected to dry pressing and granulation to obtain the granular Chinese medicine composition.

7. The method according to claim 6, characterized in that: The decoction with water is performed twice, and each decoction is performed for 1-1.5 hours.

8. The method according to claim 6, characterized in that: The reduced pressure concentration treatment comprises the following steps: at 60-65° C., the filtrate is concentrated under reduced pressure to a clear paste with a relative density of 1.05-1.

10.

9. A capsule for treating vertigo, characterized in that: A Chinese medicine composition comprising any one of claims 1 to 4.

10. An oral liquid for treating vertigo, characterized in that: A Chinese medicine composition comprising any one of claims 1 to 4.