Traditional Chinese medicine composition for treating migraine and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating migraine as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Comprising the following medicinal raw materials: gastrodia elata, corydalis tuber, ghostplant wormwood herb, codonopsis pilosula, fructus amomi, fennel, combined spicebush root, vine of multiflower knotweed, cortex albiziae, salvia miltiorrhiza, ginger-processed officinal magnolia bark, bran-fried fructus aurantii, fried semen raphani, poria cocos, bighead atractylodes rhizome, rhizoma pinellinae praeparata, citrus chachiensis hortorum, stiff silkworm, fried malt, cassia twig, white paeony root, vinegar-processed rhizoma cyperi and honey-fried licorice root. The invention further discloses a preparation method and application of the traditional Chinese medicine composition. The prescription provided by the invention runs through the whole period of migraine, breaks through the dilemma that migraine is easy to repeatedly attack and become chronic, reduces the intensity of headache, reduces the attack frequency, shortens the duration time and reduces the use of analgesic for patients by integrally regulating the liver, spleen and stomach, thereby reducing the side effects. Complications such as digestive system problems, sleep disorders and emotional fluctuation of the patient can be improved, so that the life quality of the patient is remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating migraine, and a preparation method and application thereof. Background Art

[0002] Migraine is a disease characterized by recurrent headaches on one or both sides of the head, often accompanied by symptoms of autonomic nervous system dysfunction such as nausea, vomiting, photophobia and phonophobia. The prevalence of migraine has been on the rise in recent years. It is more common in young and middle-aged people and is highly disabling and crippling. The pathogenesis of migraine is not yet fully understood. The more classic theories include vascular theory, cortical spreading inhibition theory, trigeminal neurovascular theory, inflammatory mediator theory, central nervous system theory, and genetic theory. It is currently believed that migraine aura is related to cortical spreading inhibition theory, and migraine is related to the activation of the trigeminal neurovascular system. The release of proinflammatory factors leads to a decrease in the central pain threshold, causing a disorder of central regulation balance, followed by a sensitized state of the trigeminal neurovascular system, and then sterile neurogenic inflammation, mast cell degranulation, and dilation changes in meningeal blood vessels, which induce abnormal pain sensations. In recent years, studies have found that there is a certain pathophysiological relationship between right-to-left shunting caused by patent foramen ovale and the occurrence of migraine with aura.

[0003] In Western medicine, the classic treatment methods for migraine are mainly acute treatment and preventive treatment. Regarding the recommended treatment drugs for acute migraine attacks, the most widely used ones are non-steroidal anti-inflammatory drugs (such as aspirin), triptans (such as sumatriptan) and ergotamines (such as ergotamine tartrate); preventive drugs in the remission period include calcium channel blockers (such as flunarizine), beta-receptor blockers (such as metoprolol), antiepileptic drugs (such as valproic acid), antidepressants (such as amitriptyline), etc. However, patients benefit little from these two classic treatment methods. Temporary pain relief for headache attacks is equivalent to "cramming at the last minute". Long-term use of painkillers is not only prone to drug-dependent headaches, but also common gastrointestinal and other adverse reactions. With the continuous deepening of research on migraine biomarkers, new migraine drugs centered on migraine biomarker targets are gradually emerging, but their high prices and limited efficacy are also prohibitive. Migraine belongs to the category of "head wind" and "headache" in traditional Chinese medicine. In 1994, the "Standards for Diagnosis and Therapeutic Effect Evaluation of Head Wind" divided it into five types: liver yang hyperactivity type, phlegm turbidity type, blood stasis blocking brain meridians type, qi and blood deficiency type, liver and kidney yin deficiency type. Pain is caused by obstruction and pain is caused by lack of nourishment. The causes are nothing more than exogenous and internal injuries. Internal injuries are mostly caused by wind, fire, phlegm, and blood stasis, and are mostly blamed on the liver, spleen, and kidney. During the attack period, the symptoms of migraine are mainly characterized by blood stasis and wind evil. The symptoms during the remission period are mainly manifested by liver qi stagnation, among which liver yang hyperactivity is the main syndrome. Therefore, migraine is mostly treated from the perspective of liver, spleen, and kidney as a common internal treatment method. In clinical practice, a variety of treatments are often used, such as promoting blood circulation and removing blood stasis, calming the liver and extinguishing wind, regulating qi and relieving depression, and nourishing the liver and kidney, all of which have shown certain efficacy.

[0004] For patients with migraine, conventional clinical auxiliary examinations, such as head CT and nuclear magnetic resonance, are often difficult to find positive results. The inventor of the present application believes that no matter what the cause of migraine is, as the disease progresses, patients are often accompanied by anxiety and depression symptoms. Emotional fluctuations cause damage to the liver, leading to liver qi stagnation, unable to be properly vented, and then affecting the spleen and stomach function, making the spleen and stomach weak and unable to generate enough qi and blood to nourish the head. In addition, the cold properties of taking painkillers or irregular eating habits may further damage the spleen and stomach, leading to endogenous phlegm and dampness, hindering the normal function of the liver, and forming a pathological state of soil stagnation and wood depression. Whether it is mutual restraint or mutual influence, whether it is from the spleen and stomach to the liver, or from the liver depression to the spleen and stomach, it will eventually lead to dysfunction of the three organs of the liver, spleen, and stomach, and there are rarely cases of single organ disease. Therefore, during treatment, the interaction of these three organs should be considered comprehensively. Moreover, the complications that migraine may cause cannot be ignored. Patients often suffer from gastrointestinal discomfort such as nausea, vomiting, indigestion, diarrhea, constipation, and gastrointestinal diseases such as irritable bowel syndrome and inflammatory gastrointestinal disease. According to the theoretical thinking of traditional Chinese medicine, these symptoms and diseases are collectively referred to as migraine-related spleen and stomach comorbidities, and may be accompanied by anxiety, depression, insomnia and other physical and mental diseases, which can be explained by the core pathogenesis of "liver, spleen and stomach disorders". There is currently a lack of Chinese patent medicines for this new migraine pathogenesis. Therefore, it is necessary to objectively evaluate clinical needs and solve this treatment problem.

[0005] In view of this, the inventor conducted in-depth research on this demand, and thus the present case was produced. Summary of the invention

[0006] After long-term clinical observation and continuous exploration, the present invention regards "liver qi stagnation, spleen and stomach weakness, and liver, spleen and stomach qi disorder" as the core pathogenesis of migraine, and in response to this core pathogenesis, provides a Chinese medicine composition for treating migraine and its preparation method and application, which aims to soothe the liver and relieve depression, strengthen the spleen and harmonize the middle, regulate the liver, spleen and stomach qi, and play an overall regulating role in migraine without aura in all stages of migraine (including the whole cycle including the remission period and the attack period), accompanied by nausea and vomiting, stomach and abdominal distension and pain, indigestion, constipation, irritable bowel syndrome, chronic gastroenteritis and other spleen and stomach comorbidities, or concurrent physical and mental diseases such as anxiety, depression, insomnia, etc., and can reduce or even stop the use of painkillers.

[0007] The technical solution adopted by the present invention is as follows:

[0008] A traditional Chinese medicine composition for treating migraine comprises the following medicinal raw materials in parts by weight: 5-20 parts of Gastrodia elata, 5-20 parts of Corydalis yanhusuo, 5-20 parts of Artemisia argyi, 5-20 parts of Codonopsis pilosula, 1-15 parts of Amomum villosum, 1-15 parts of fennel, 5-20 parts of Linderae umbellatae, 15-35 parts of Polygonum multiflorum vine, 15-35 parts of Albizzia julibrissin bark, 5-25 parts of Salvia miltiorrhiza, 5-20 parts of Magnolia officinalis bark, 5-20 parts of stir-fried Citrus aurantium with bran, 10-25 parts of stir-fried Radish seeds, 5-25 parts of Poria cocos, 10-25 parts of Atractylodes macrocephala, 1-15 parts of Pinellia ternata, 1-15 parts of Citrus reticulata peel, 1-15 parts of Bombyx batryticatus, 10-25 parts of stir-fried malt, 1-15 parts of cinnamon twig, 5-25 parts of white peony root, 5-20 parts of vinegar-sweetened Cyperus rotundus, and 1-15 parts of roasted Licorice root.

[0009] Preferably, the following medicinal raw materials are included in proportion by weight: 7-18 parts of Gastrodia elata, 7-18 parts of Corydalis yanhusuo, 7-18 parts of Artemisia rapa, 7-18 parts of Codonopsis pilosula, 3-13 parts of Amomum villosum, 3-13 parts of fennel, 7-18 parts of Linderae strychnifolia, 17-33 parts of Polygonum multiflorum, 17-33 parts of Albizzia julibrissin, 7-23 parts of Salvia miltiorrhiza, 7-18 parts of Magnolia officinalis bark, 7-18 parts of stir-fried Citrus aurantium with bran, 12-23 parts of stir-fried Radish seeds, 7-23 parts of Poria cocos, 12-23 parts of Atractylodes macrocephala, 3-13 parts of Pinellia ternata, 3-13 parts of Citrus reticulata, 3-13 parts of Bombyx batryticatus, 12-23 parts of stir-fried malt, 3-13 parts of cinnamon twig, 7-23 parts of white peony root, 7-18 parts of vinegar-scented Cyperus rotundus, and 3-13 parts of roasted Licorice root.

[0010] Preferably, the following medicinal raw materials are included in proportion by weight: 10-15 parts of Gastrodia elata, 10-15 parts of Corydalis yanhusuo, 10-15 parts of Artemisia argyi, 10-15 parts of Codonopsis pilosula, 5-10 parts of Amomum villosum, 5-10 parts of fennel, 10-15 parts of Linderae strychnifolia, 20-30 parts of Polygonum multiflorum, 20-30 parts of Albizzia julibrissin, 10-20 parts of Salvia miltiorrhiza, 10-15 parts of Magnolia officinalis bark, 10-15 parts of stir-fried Citrus aurantium with bran, 15-20 parts of stir-fried radish seeds, 10-20 parts of Poria cocos, 15-20 parts of Atractylodes macrocephala, 5-10 parts of Pinellia ternata, 5-10 parts of Citrus reticulata peel, 5-10 parts of Bombyx batryticatus, 15-20 parts of stir-fried malt, 5-10 parts of cinnamon twig, 10-20 parts of white peony root, 10-15 parts of vinegar-scented Cyperus rotundus, and 5-10 parts of roasted Licorice root.

[0011] The present invention also provides the use of the above-mentioned Chinese medicine composition for treating migraine in preparing a medicine for treating migraine, especially in preparing a medicine for treating migraine without aura.

[0012] The present invention also provides a medicine for treating migraine, comprising the above-mentioned Chinese medicine composition for treating migraine and pharmaceutically acceptable excipients.

[0013] Preferably, the dosage form of the drug is a Chinese medicine decoction, decoction, granules, pills, paste, capsules, tablets, tea, suspension, powder or oral solution.

[0014] The present invention also provides a method for preparing the above-mentioned medicine for treating migraine, wherein the medicine is a Chinese medicine decoction, and the preparation method thereof is as follows:

[0015] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0016] Step 2, add 6 to 8 times the volume of the raw material medicine taken in step 1 of clean water and soak for 30 to 50 minutes, then boil with high heat, then continue to decoct with low heat for 30 to 45 minutes, filter with a Chinese medicine sieve to obtain a first filtrate; then add water to the residue to cover the residue, boil with high heat, then continue to decoct with low heat for 30 to 45 minutes, use a Chinese medicine sieve to filter out the residue to obtain a second filtrate; combine the first filtrate and the second filtrate to obtain a Chinese medicine decoction.

[0017] The present invention also provides a method for preparing the above-mentioned drug for treating migraine, wherein the drug is an ointment, and the preparation method thereof is as follows:

[0018] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0019] Step 2, adding 6 to 8 times the volume of the raw material medicine obtained in step 1 into water and soaking for 30 to 50 minutes, then boiling over high heat, then changing to low heat and continuing to decoct for 30 to 45 minutes, filtering with a Chinese medicine sieve to obtain a first filtrate; then adding water to the drug residue to cover the drug residue, boiling over high heat, changing to low heat and continuing to decoct for 30 to 45 minutes, filtering out the drug residue with a Chinese medicine sieve to obtain a second filtrate; combining the first filtrate and the second filtrate;

[0020] Step three, simmer the combined filtrate of step two at 100-120° C. over low heat with constant stirring, and when the drug is thick, pour the ointment into a dry container to obtain an ointment.

[0021] The beneficial effects produced by the technical solution of the present invention are as follows:

[0022] The Chinese medicine composition of the present invention uses Gastrodia elata, Corydalis yanhusuo and Cyperus rotundus as the main drugs. Gastrodia elata extinguishes wind and soothes the liver, dispels wind and unblocks collaterals to relieve pain, Corydalis yanhusuo soothes the liver and promotes qi, promotes blood circulation and relieves pain, and Cyperus rotundus promotes qi and relieves depression, regulates menstruation and relieves pain. The three drugs are used together to regulate qi and promote blood circulation, soothe the liver and calm the wind, and promote qi and relieve pain; Codonopsis pilosula invigorates the spleen and replenishes the middle, helps the middle jiao to transport and transform, so that the spleen is invigorated and moisturized, qi and blood are abundant, and the spleen and stomach pivots are unobstructed; cumin, Linderae umbellatae and Amomum villosum warm the middle and relieve pain, promote qi and harmonize the stomach, and Albizzia julibrissin and Polygonum multiflorum nourish blood and soften the liver, calm the nerves and relieve pain. The above drugs soothe and soften the liver at the same time, and regulate qi and blood. They are all ministerial drugs; white atractylodes and poria are used to strengthen the effect of strengthening the spleen and replenishing qi, and duck foot wormwood, tangerine peel, and pinellia are used to imply the meaning of Erchen Decoction to dry dampness and resolve turbidity. Citrus aurantium and Magnolia bark can lower qi and clear the bowels, malt and radish seeds can soothe the liver and lower the stomach, and cinnamon twig and white peony root are used together to harmonize the Ying and Wei, with the spleen and stomach as the source of qi, blood, Ying and Wei, and biochemistry. Bombyx batryticatus can calm the wind and stop spasm, dispel wind and relieve pain, resolve phlegm and disperse knots, and is good at running the head and face collaterals, searching for wind and resolving phlegm, and treating stubborn and intractable headaches. Salvia miltiorrhiza has the effect of promoting blood circulation, removing blood stasis, unblocking collaterals and relieving pain; roasted licorice is used to tonify the middle and harmonize the drugs. The combination of the drugs can make the liver qi smooth, the spleen qi healthy, the stomach qi smooth, the dampness and turbidity can be resolved, and the headache will stop when the qi is smooth.

[0023] The Chinese medicine composition of the present invention proposes that the core pathogenesis of migraine is based on spleen and stomach weakness, qi and blood deficiency, liver, spleen and stomach qi disorder as the standard, throughout the entire cycle of migraine, so the Chinese medicine composition provided by the present invention is dynamically and holistically treated by regulating the liver, spleen and stomach as a whole, not sticking to the difference between the attack period and the remission period, and striving to treat migraine in the whole cycle and the whole view, breaking the dilemma of migraine prone to repeated attacks and chronicity, and not sticking to the acute attack period and the remission period staged treatment mode. In addition, the present invention can reduce the intensity of headaches, reduce the frequency of attacks, shorten the duration, reduce the use of analgesics by patients during the migraine attack period, reduce the side effects of analgesics, and effectively interrupt the vicious cycle of headaches. In this regard, this side also has a positive improvement effect on the patient's various complications, such as spleen and stomach related comorbidities, sleep disorders and mood swings and other physical and mental diseases, thereby significantly improving the patient's quality of life. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Therefore, the following detailed description of the embodiments provided by the present invention is not intended to limit the scope of the claimed invention, but merely represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] This embodiment finds that the traditional Chinese medicine prescriptions and Chinese patent medicines commonly used in clinical practice that mainly use methods such as promoting blood circulation and removing blood stasis, dispelling wind and calming the liver have limited therapeutic effects on migraine. From clinical observations, in addition to common liver-related symptoms such as emotional distress, migraine is often accompanied by symptoms such as poor appetite, diarrhea, acid reflux, belching, and even stomachache and other spleen and stomach discomfort, or there are gastrointestinal diseases such as chronic gastritis and chronic enteritis in the past, and gastrointestinal symptoms are induced by staying up late, drinking, etc. first, and then migraine occurs, or migraine occurs first, and then accompanied by gastrointestinal discomfort symptoms. In response to complex symptoms, the applicant proposes that the core pathogenesis of migraine is spleen and stomach weakness, qi and blood deficiency as the basis, and liver, spleen and stomach qi disorder as the symptom. Clinically, the treatment method is to "relieve depression and harmonize the middle, and regulate the liver, spleen and stomach qi", follow the principle of "treating the spleen is not far from the stomach, treating the stomach and spleen, and treating the spleen and stomach must be connected with the liver", and adopt the liver, spleen and stomach trinity coordinating treatment. This prescription can soothe and soften the liver and relieve depression, and strengthen the spleen and harmonize the stomach to raise the clear and lower the turbid to harmonize the middle. Therefore, this prescription is also known as the "Depression-Resolving and Middle-Harmonizing Method". It is used to treat migraine. In clinical practice, the addition and subtraction are made according to the different pathogenesis of the liver, spleen, and stomach. The method is flexible and the clinical effect is significant.

[0026] The invention provides a traditional Chinese medicine composition for treating migraine, comprising the following medicinal raw materials in parts by weight: 5-20 parts of gastrodia elata, 5-20 parts of yam, 5-20 parts of wormwood, 5-20 parts of codonopsis pilosula, 1-15 parts of amomum villosum, 1-15 parts of fennel, 5-20 parts of lindera strychnifolia, 15-35 parts of radix polygoni multiflori, 15-35 parts of julibrissin bark, 5-25 parts of salvia miltiorrhiza, 5-20 parts of ginger magnolia bark, 5-20 parts of fried aurantium wilfordii with bran, 10-25 parts of fried radish seeds, 5-25 parts of tuckahoe, 10-25 parts of atractylodes macrocephala, 1-15 parts of pinellia ternata, 1-15 parts of tangerine peel, 1-15 parts of bombyx batryticatus, 10-25 parts of fried malt, 1-15 parts of cassia twig, 5-25 parts of white peony root, 5-20 parts of vinegar-flavored cyperus, and 1-15 parts of roasted liquorice.

[0027] As a preferred embodiment, the invention comprises the following medicinal raw materials in parts by weight: 7-18 parts of Gastrodia elata, 7-18 parts of Corydalis yanhusuo, 7-18 parts of Artemisia argyi, 7-18 parts of Codonopsis pilosula, 3-13 parts of Amomum villosum, 3-13 parts of fennel, 7-18 parts of Linderae strychnifolia, 17-33 parts of Polygonum multiflorum, 17-33 parts of Albizzia julibrissin, 7-23 parts of Salvia miltiorrhiza, 7-18 parts of Magnolia officinalis bark, 7-18 parts of fried Citrus aurantium with bran, 12-23 parts of fried radish seeds, 7-23 parts of Poria cocos, 12-23 parts of Atractylodes macrocephala, 3-13 parts of Pinellia ternata, 3-13 parts of Citrus reticulata, 3-13 parts of Bombyx batryticatus, 12-23 parts of fried malt, 3-13 parts of cinnamon twig, 7-23 parts of white peony root, 7-18 parts of vinegar Cyperus rotundus, and 3-13 parts of roasted licorice.

[0028] As a preferred embodiment, the invention comprises the following medicinal raw materials in parts by weight: 10-15 parts of Gastrodia elata, 10-15 parts of Corydalis yanhusuo, 10-15 parts of Artemisia argyi, 10-15 parts of Codonopsis pilosula, 5-10 parts of Amomum villosum, 5-10 parts of fennel, 10-15 parts of Linderae strychnos atractylodes, 20-30 parts of Polygonum multiflorum, 20-30 parts of Albizzia julibrissin, 10-20 parts of Salvia miltiorrhiza, 10-15 parts of Magnolia officinalis bark, 10-15 parts of fried Citrus aurantium with bran, 15-20 parts of fried radish seeds, 10-20 parts of Poria cocos, 15-20 parts of Atractylodes macrocephala, 5-10 parts of Pinellia ternata, 5-10 parts of Citrus reticulata peel, 5-10 parts of Bombyx batryticatus, 15-20 parts of fried malt, 5-10 parts of cinnamon twig, 10-20 parts of white peony root, 10-15 parts of vinegar Cyperus rotundus, and 5-10 parts of roasted Licorice root.

[0029] The present invention also provides the use of the above-mentioned Chinese medicine composition for treating migraine in preparing a medicine for treating migraine, especially in preparing a medicine for treating migraine without aura.

[0030] The present invention also provides a medicine for treating migraine, comprising the above-mentioned Chinese medicine composition for treating migraine and pharmaceutically acceptable excipients.

[0031] As a preferred embodiment, the dosage form of the drug is a Chinese medicine decoction, decoction, granules, pills, paste, capsules, tablets, tea, suspension, powder or oral liquid.

[0032] The present invention also provides a method for preparing the above-mentioned medicine for treating migraine, wherein the medicine is a Chinese medicine decoction, and the preparation method thereof is as follows:

[0033] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0034] Step 2, add 6 to 8 times the volume of the raw material medicine taken in step 1 into water and soak for 30 to 50 minutes, then boil over high heat, and then continue to decoct over low heat for 30 to 45 minutes;

[0035] Step three, filtering with a Chinese medicine sieve to obtain a first filtrate; then adding water to the medicinal residue to cover the medicinal residue, boiling over high heat, then simmering over low heat for 30 to 45 minutes, filtering out the medicinal residue with a Chinese medicine sieve to obtain a second filtrate; combining the first filtrate and the second filtrate to obtain a Chinese medicine decoction.

[0036] The present invention is further described in detail below in conjunction with specific embodiments:

[0037] Example 1

[0038] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 5 parts of Gastrodia elata, 5 parts of Corydalis yanhusuo, 5 parts of Artemisia argyi, 5 parts of Codonopsis pilosula, 1 part of Amomum villosum, 1 part of Cuminum officinale, 5 parts of Linderae rutinae, 15 parts of Polygonum multiflorum, 15 parts of Albizzia julibrissin, 5 parts of Salvia miltiorrhiza, 5 parts of Magnolia officinalis, 5 parts of Stir-fried Fructus Aurantii Immaturus with bran, 10 parts of Stir-fried Radish Seed, 5 parts of Poria, 10 parts of Atractylodes macrocephala, 1 part of Pinellia ternata, 1 part of Citrus reticulatae, 1 part of Bombyx batryticatus, 10 parts of Stir-fried Malt, 1 part of Cinnamon twig, 5 parts of White Peony Root, 5 parts of Vinegar Cyperus, and 1 part of Roasted Licorice. The preparation method of the medicine for treating migraine in Example 1 is as follows:

[0039] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0040] Step 2: Add 7 times the volume of the raw material drug taken in step 1 into water and soak for 40 minutes, then boil over high heat, and then continue to boil over low heat for 40 minutes;

[0041] Step three, filtering with a Chinese medicine sieve to obtain a first filtrate; then adding water to the residue to cover the residue, boiling over high heat, then simmering over low heat for 40 minutes, filtering out the residue with a Chinese medicine sieve to obtain a second filtrate; combining the first filtrate and the second filtrate to obtain a Chinese medicine decoction.

[0042] Example 2

[0043] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 7 parts of Gastrodia elata, 7 parts of Corydalis yanhusuo, 7 parts of Artemisia argyi, 7 parts of Codonopsis pilosula, 3 parts of Amomum villosum, 3 parts of Cuminum officinale, 7 parts of Linderae strychnifolia, 17 parts of Polygonum multiflorum, 17 parts of Albizzia julibrissin, 7 parts of Salvia miltiorrhiza, 7 parts of Magnolia officinalis, 7 parts of Stir-fried Citrus aurantium with bran, 12 parts of Stir-fried Radish Seed, 7 parts of Poria, 12 parts of Atractylodes macrocephala, 3 parts of Pinellia ternata, 3 parts of Citrus reticulatae, 3 parts of Bombyx batryticatus, 12 parts of Stir-fried Malt, 3 parts of Cinnamon twig, 7 parts of White Peony Root, 7 parts of Vinegar Cyperus, and 3 parts of Roasted Licorice. The preparation method of the medicine for treating migraine in this embodiment 2 is the same as that in embodiment 1.

[0044] Example 3

[0045] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 10 parts of Gastrodia elata, 10 parts of Corydalis yanhusuo, 10 parts of Artemisia argyi, 10 parts of Codonopsis pilosula, 5 parts of Amomum villosum, 5 parts of Cuminum officinale, 10 parts of Linderae rutaecarpa, 20 parts of Polygonum multiflorum, 20 parts of Albizzia julibrissin, 10 parts of Salvia miltiorrhiza, 10 parts of Magnolia officinalis, 10 parts of Stir-fried Citrus aurantium with bran, 15 parts of Stir-fried Radish Seed, 10 parts of Poria, 15 parts of Atractylodes macrocephala, 5 parts of Pinellia ternata, 5 parts of Citrus reticulatae, 5 parts of Bombyx batryticatus, 15 parts of Stir-fried Malt, 5 parts of Cinnamon twig, 10 parts of White Peony Root, 10 parts of Vinegar Cyperus, and 5 parts of Roasted Licorice. The preparation method of the medicine for treating migraine in this embodiment 3 is the same as that in embodiment 1.

[0046] Example 4

[0047] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 15 parts of Gastrodia elata, 15 parts of Corydalis yanhusuo, 15 parts of Artemisia argyi, 15 parts of Codonopsis pilosula, 10 parts of Amomum villosum, 10 parts of Cuminum officinale, 15 parts of Linderae rutinae, 30 parts of Polygonum multiflorum, 30 parts of Albizzia julibrissin, 20 parts of Salvia miltiorrhiza, 15 parts of Magnolia officinalis, 15 parts of fried Citrus aurantium with bran, 20 parts of fried Radish seeds, 20 parts of Poria, 20 parts of Atractylodes macrocephala, 10 parts of Pinellia ternata, 10 parts of Citrus reticulatae, 10 parts of Bombyx batryticatus, 20 parts of fried Malt, 10 parts of Cinnamon twig, 20 parts of White Peony Root, 15 parts of Vinegar Cyperus, and 10 parts of Roasted Licorice. The preparation method of the medicine for treating migraine in Example 4 is as follows:

[0048] Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly;

[0049] Step 2: add 7 times the volume of the raw material drug taken in step 1 into water and soak for 40 minutes, then boil over high heat, then continue to decoct over low heat for 40 minutes, filter through a Chinese medicine sieve to obtain a first filtrate; then add water to the residue to cover the residue, boil over high heat, then continue to decoct over low heat for 40 minutes, filter through a Chinese medicine sieve to remove the residue, and obtain a second filtrate; combine the first filtrate and the second filtrate;

[0050] Step 3, simmer the combined filtrate of step 2 at 120° C. over low heat with constant stirring, and when the medicine is thick, pour the ointment into a dry container to obtain an ointment.

[0051] Example 5

[0052] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 18 parts of Gastrodia elata, 18 parts of Corydalis yanhusuo, 18 parts of Artemisia argyi, 18 parts of Codonopsis pilosula, 13 parts of Amomum villosum, 13 parts of Cuminum officinale, 18 parts of Linderae rutaecarpa, 33 parts of Polygonum multiflorum, 33 parts of Albizzia julibrissin, 23 parts of Salvia miltiorrhiza, 18 parts of Magnolia officinalis, 18 parts of Stir-fried Citrus aurantium with bran, 23 parts of Stir-fried Radish Seed, 23 parts of Poria, 23 parts of Atractylodes macrocephala, 13 parts of Pinellia ternata, 13 parts of Pericarpium Citri Reticulatae, 13 parts of Bombyx batryticatus, 23 parts of Stir-fried Malt, 13 parts of Cinnamon twig, 23 parts of White Peony Root, 18 parts of Cyperus rotundus with vinegar, and 13 parts of Radix Glycyrrhizae. The preparation method of the medicine for treating migraine in this embodiment 5 is the same as that in embodiment 4.

[0053] Example 6

[0054] A Chinese medicine composition for treating migraine, wherein the Chinese medicine formula raw materials are grabbed according to the following mass parts: 20 parts of Gastrodia elata, 20 parts of Corydalis yanhusuo, 20 parts of Artemisia argyi, 20 parts of Codonopsis pilosula, 15 parts of Amomum villosum, 15 parts of Cuminum officinale, 20 parts of Linderae rutaecarpa, 35 parts of Polygonum multiflorum, 35 parts of Albizzia julibrissin, 25 parts of Salvia miltiorrhiza, 20 parts of Magnolia officinalis, 20 parts of Stir-fried Citrus aurantium with bran, 25 parts of Stir-fried Radish Seed, 25 parts of Poria, 25 parts of Atractylodes macrocephala, 15 parts of Pinellia ternata, 15 parts of Pericarpium Citri Reticulatae, 15 parts of Bombyx batryticatus, 25 parts of Stir-fried Malt, 15 parts of Cinnamon twig, 25 parts of White Peony Root, 20 parts of Vinegar Cyperus, and 15 parts of Roasted Licorice. The preparation method of the medicine for treating migraine in this embodiment 6 is the same as that in embodiment 4.

[0055] Through decades of clinical experience, the present invention summarizes and proposes the Jieyu Hezhong Tongling Fang for treating migraine, and publishes the "Huarong Database on Treating Migraine", which writes that the commonly used drugs for the Jieyu Hezhong Tongling Fang for treating migraine include: Poria, Atractylodes macrocephala, Codonopsis pilosula, Pinellia ternata, Citrus reticulata, Roasted Licorice, Cyperus rotundus with vinegar, Amomum villosum, stir-fried malt, stir-fried radish seeds, Magnolia officinalis, stir-fried Citrus aurantium with bran, cumin, Linderae scutellariae, Corydalis yanhusuo, Artemisia argyi, Cassia twig, White peony root, Polygonum multiflorum vine, Albizzia julibrissin bark, etc.; later, on the basis of the Jieyu Hezhong Tongling Fang combination, the auxiliary drug Salvia miltiorrhiza is added, which has the effects of promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, and removing restlessness and tranquilizing the mind, and its function is to promote blood circulation, dredge collaterals and relieve pain; Bombyx batryticatus can calm wind and stop spasm, dispel wind and relieve pain, resolve phlegm and disperse nodules, and has a wandering nature. It is good at running the head and face collaterals, searching for wind and resolving phlegm, and treating stubborn and intractable headaches; Gastrodia elata can extinguish wind and calm the liver, and dispel wind and dredge collaterals. The application of the above three herbs is based on the original prescription to soothe the liver, strengthen the spleen, and harmonize the middle. It targets the characteristics of wind, phlegm, blood stasis, etc. when headache attacks, and achieves the purpose of treating both the symptoms and the root causes. It can better relieve pain, reduce the severity of headache attacks, and reduce the frequency of headaches. The specific clinical trial data are as follows:

[0056] The drug prepared in the preferred embodiment 3 was used to conduct experiments to identify the effect of the dosage used in the present invention on the drug efficacy:

[0057] 1. Case source

[0058] Patients who were hospitalized in our hospital for migraine from 2022 to 2023 and met the selection and diagnostic criteria.

[0059] 2. Selection criteria

[0060] (1) Meet the Western medical diagnostic criteria for migraine;

[0061] (2) Meet the TCM diagnostic criteria for headache;

[0062] (3) The patient's basic medical information was complete and he / she received Chinese herbal decoction treatment at the first visit;

[0063] (4) Other types of migraine cases, such as tension-type headache, cluster headache, and secondary migraine cases, were excluded, and patients who were unwilling to receive Chinese medicine treatment would not be included in the study.

[0064] 3. Diagnostic criteria

[0065] 3.1 Western medicine standards: According to the classification and diagnostic criteria for migraine in the "International Classification of Headache Disorders (3rd Edition)" published by the Classification Committee of the International Headache Society in 2018.

[0066] (1) Headache attacks last for 4 to 72 hours (untreated or ineffective treatment).

[0067] (2) The headache has at least two of the following four characteristics: ① lateral distribution; ② pulsating; ③ moderate or severe pain; ④ daily physical activities aggravate the headache or avoid daily activities (such as walking or climbing stairs) due to the headache.

[0068] (3) At least one of the following symptoms occurs during a headache: ① nausea and / or vomiting; ② photophobia and / or phonophobia.

[0069] At least five headache attacks that meet all of (1), (2), or (3) and are not better explained by another ICHD-3 headache disorder diagnosis.

[0070] 3.2 Traditional Chinese Medicine Standards: Refer to the Traditional Chinese Medicine diagnosis of “head wind” in the “Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes” issued by the State Administration of Traditional Chinese Medicine in 2016.

[0071] 4. Treatment options

[0072] 60 patients with migraine who were treated were randomly selected, and a Chinese medicine decoction was prepared using the preferred embodiment 3 of the present invention. One dose was taken per day, and one dose was 250 mL. Seven days constituted one course of treatment. The efficacy was statistically analyzed after taking the medicine for four courses of treatment. The patients were advised to regulate their emotions, pay attention to their work and rest schedule, and have a light diet.

[0073] 5. Efficacy standards

[0074] The clinical efficacy is formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines". If headache symptoms completely disappear, such as when there is a record of "no attack", it is recorded as clinical cure; if the headache intensity, duration, frequency and accompanying symptoms are significantly improved, and each attack basically does not affect normal life and work, such as when there is a record of "significant relief", "significant reduction", "significant improvement" and "stop using painkillers", it is markedly effective; if the headache intensity, duration, frequency and accompanying symptoms are improved, and each attack slightly affects normal work, such as when there is a record of "relief", "relief", "improvement" and "stop using painkillers", it is recorded as effective; if the headache intensity, duration, frequency and accompanying symptoms do not improve or worsen, and bed rest is required during an attack, such as when there is a record of "worsened" and "still have headache, accompanied by vomiting when the pain is severe", it is recorded as ineffective.

[0075] 6. Data Analysis

[0076] The patients treated with the Chinese medicine composition prepared in Example 3 of the present invention were compared with 60 patients who showed significant improvement using the previously published Jieyu and Zhongtongling prescriptions in the "Huarong Migraine Treatment Database" for efficacy-related indicators.

[0077] 6.1 Overall effective rate of treatment

[0078] Table 1 Total effective rate of treatment

[0079]

[0080] As shown in Table 1, the results show that the total effective rate of the Chinese medicine composition of the present invention is higher than that of the Jieyu and Zhongtongling prescription groups, and after 4 courses of treatment and follow-up, the clinical cure rate of the Chinese medicine composition of the present invention is higher than that of the Jieyu and Zhongtongling prescription groups, indicating that after the improvement and innovation of the formula, the present invention is superior to the previous Jieyu and Zhongtongling prescriptions in the efficacy of long-term improvement of headaches.

[0081] 6.2 Improvement of headache severity

[0082] Table 2 VAS improvement before and after treatment

[0083]

[0084] As shown in Table 2, with reference to the visual analogue scale (VAS scale) as the standard, the two groups of patients were compared before and after treatment. The degree of reduction in VAS score of the present invention was higher than that of the Jieyu and Zhongtongling prescription groups, indicating that the present invention can play a more significant role in relieving the degree of headache than before the improvement. By adding blood-activating and wind-dispelling drugs, the effect of "treating the symptoms in an emergency" is played during the headache attack period. The present invention can play a more significant role in relieving the degree of headache attack.

[0085] 6.3 Reduction of painkillers

[0086] Table 3 Improvement in the use of analgesics after treatment

[0087]

[0088] As shown in Table 3, after the treatment with the Chinese medicine composition of the present invention, 15 patients stopped taking analgesics, and 35 patients reduced the dosage of analgesics, accounting for 90.91% of the patients taking analgesics. The proportion of patients who stopped taking analgesics or reduced the dosage of analgesics in the treatment group of the present invention was higher than that in the Jieyu and Zhongtongling prescription groups, indicating that the Chinese medicine composition of the present invention can more significantly improve and reduce the use of analgesics, prevent new migraine patients from falling into a vicious cycle of analgesic dependence, and enable patients with refractory drug overdose migraine to gradually get rid of drug overdose and drug dependence, thus playing a role in long-term treatment.

[0089] 6.4 Number of days required for effective treatment

[0090] Table 4 Average days from taking medication to showing effect

[0091]

[0092] As shown in Table 4, compared with the original Jieyu and Zhongtongling prescriptions, the time for the Chinese medicine composition of the present invention to achieve significant effect in treating headache is shorter than that of the original Jieyu and Zhongtongling prescriptions, indicating that after adding relevant drugs, the Chinese medicine composition of the present invention can improve headache symptoms in a shorter period of time, reduce the severity of headache attacks, play a therapeutic role faster, reduce the patient's pain, increase the patient's trust in the treatment, and ensure that the patient can complete the drug treatment.

[0093] The Chinese medicine composition of the present invention is based on the understanding of the TCM etiology and pathogenesis of migraine "liver, spleen and stomach disorders" summarized by the applicant's long-term clinical research, and is improved by adding and subtracting the Jieyu and Zhongtongling prescriptions with definite efficacy in the past, and has the effects of soothing the liver and relieving depression, strengthening the spleen and stopping pain. By comparing the efficacy data before and after addition and subtraction, it is confirmed that the addition of three medicines, Gastrodia elata, Bombyx batryticatus and Salvia miltiorrhiza, strengthens the power of promoting blood circulation and unblocking collaterals, dispelling wind and stopping pain, regulates the liver, spleen and stomach as a whole, can relieve headache faster, and more significantly reduce the degree of headache, thereby reducing the use of analgesics and avoiding the effect of causing drug overdose headache. This prescription also has a positive improvement effect on the various complications of patients, such as migraine-related spleen and stomach comorbidities, sleep disorders and mood swings and other physical and mental diseases, thereby significantly improving the quality of life of patients. The invention has definite efficacy, the prescription does not contain toxic drugs specified in the pharmacopoeia, and the medication is safe. It is a major innovation in the treatment of migraine and has strong clinical value.

[0094] Typical cases:

[0095] Case 1: Li, female, 30 years old, first visited the hospital in September 2024, with paroxysmal right temporal and orbital pain for 5 years, aggravated for 1 year. The patient began to have regular migraine attacks 5 years ago. In November 2023, she underwent foramen ovale closure in an external hospital. The symptoms were slightly relieved after the operation, but she still had 2 attacks a month, each lasting 48 hours, VAS: 6 points, and took ibuprofen for pain relief, but the effect was not good. The stool was constipated, the tongue was pale red, and the fur was thin and white. Western medicine diagnosed it as migraine, and Chinese medicine diagnosed it as headache (liver, spleen and stomach disorder syndrome). The Chinese medicine decoction of Example 3 provided by the present invention was taken, 1 dose per day, decocted twice, and decocted to 250-300 ml each time. It was warm after meals and treated for 21 days. After taking the medicine for a week, the patient reported a significant reduction in the degree of headache, VAS: 3 points, and the frequency of attacks decreased. At the third visit, he reported no headache for nearly 1 week, stopped taking painkillers, and had smooth bowel movements. Then take the Chinese medicine ointment prepared in Example 4 of the present invention, once in the morning and evening, 10g each time, 28 days as one course of treatment, take one course of treatment, no obvious headache attack. The results show that this prescription effectively relieves symptoms such as recurrent headaches and constipation in patients with migraine, can reduce the frequency of headache attacks, reduce the use of analgesics, and has obvious therapeutic effects on patients with migraine of liver, spleen and stomach disorders.

[0096] Case 2: Wang, female, 38 years old, first visited the hospital in October 2024, with paroxysmal headaches before and after menstruation for 4 years. The patient began to have headaches on both temporal sides after giving birth 4 years ago, accompanied by nausea and vomiting. Every time before and after menstruation, she needs to take painkillers, poor sleep, scanty menstruation, sallow complexion, pale tongue, and thin white fur. Western medicine diagnosed it as migraine, and Chinese medicine diagnosed it as menstrual headache (liver, spleen and stomach disorder syndrome). Take the Chinese medicine decoction of Example 3 provided by the present invention, 1 dose per day, decocted twice, decocted in water to 250-300 ml each time, warm after meals, and treat for 21 days. During the second visit, she reported that there was no headache during the menstrual period, so she could stop taking painkillers and take the medicine for another 21 days. Her sleep improved, and there was no headache before and after menstruation. It is shown that the present invention can effectively alleviate the headache of patients with menstrual-related migraine. After taking the medicine for one month, the headache can be cured without recurrence, the analgesics can be stopped, and the accompanying symptoms such as insomnia of the patients can be improved. It has obvious therapeutic effect on patients with migraine of liver, spleen and stomach disorders.

[0097] Case 3: Liu, female, 58 years old, first visited in July 2024, with repeated right temporal pain for more than 20 years, aggravated for 2 years. VAS: 8 points during attack, accompanied by nausea and vomiting, 4 to 5 attacks a month, lasting 48 to 72 hours, long-term use of analgesics, poor effect, mother and sister have a history of migraine, constipation, belching and acid reflux, poor appetite, pale tongue, white and greasy fur, Western medicine diagnosed as migraine, chronic headache, drug overuse headache, Chinese medicine diagnosed as headache (liver, spleen and stomach disorder syndrome), take the Chinese medicine decoction of Example 3 provided by the present invention, 1 dose per day, decocted twice, each time decocted to 250 to 300 ml, warm after meals, and treated for 21 days. The follow-up report complained that the frequency of headache attacks decreased, with 1 attack per month, shortened attack time, and reduced degree, VAS: 5 points, without nausea and vomiting, and analgesics can be discontinued. The patient's overall spirit is good and the bowel movements are smooth. After 21 days of continued treatment, the frequency of headaches decreased significantly, and the degree was mild. The Chinese medicine ointment prepared in Example 4 of the present invention was continued to be taken, once in the morning and evening, 10g each time, 28 days as a course of treatment, 2 courses of treatment, no obvious headache attacks, and basically recovered. It is shown that the present invention can effectively alleviate the headache symptoms of patients with chronic, drug-dependent migraine, and family genetic tendency, reduce the degree of pain during attacks, reduce the frequency of attacks, and can gradually reduce the use of analgesics, finally get rid of analgesics, alleviate accompanying symptoms, improve spleen and stomach related comorbidities, and overall regulate the migraine syndrome symptoms of patients, and has obvious long-term efficacy for patients with stubborn migraine of liver, spleen and stomach disorders.

[0098] Case 4: Rong, female, 39 years old, first visited the hospital in September 2024. She had repeated temporal pain before and after menstruation for more than 20 years, which worsened for 3 months, and her mother also had a history of headache for many years. The patient began to have paroxysmal temporal headaches before and after menstruation for more than 20 years, accompanied by nausea and vomiting. The pain level has worsened in the past 3 months, and she began to take painkillers. The menstrual volume is large, there are many blood clots, poor sleep, nervous and anxious mood, pale and fat tongue with tooth marks and cracks, and white and greasy fur; Western medicine diagnosed it as migraine, and Chinese medicine diagnosed it as menstrual headache (liver, spleen and stomach disorder syndrome). Take the Chinese medicine decoction of Example 3 provided by the present invention, 1 dose per day, decocted twice, decocted to 250-300 ml of water each time, warm after meals, and treat for 28 days. The follow-up visit complained of reduced headache attacks, improved sleep, and relaxed mood. After 14 days of treatment, the frequency of headaches decreased significantly, and the patient complained that he had not had a headache for nearly a month, his mental state improved significantly, and his menstrual blood clots decreased. He continued to take the Chinese medicine ointment prepared in Example 4 of the present invention, once in the morning and evening, 10g each time, 28 days as a course of treatment, and took 1 course of treatment. Occasional headaches were mild and did not affect his life. This case shows that the present invention has the effects of improving the accompanying symptoms and the tension and anxiety of migraine complications for familial migraine and menstrual-related migraine, and has an obvious long-term therapeutic effect on the overall regulation of the liver, spleen and stomach, and has a significant long-term therapeutic effect on patients with migraine with liver, spleen and stomach disorders.

[0099] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating migraine, characterized in that: The invention comprises the following medicinal raw materials in proportion by weight: 5-20 parts of Gastrodia elata, 5-20 parts of Corydalis yanhusuo, 5-20 parts of Artemisia argyi, 5-20 parts of Codonopsis pilosula, 1-15 parts of Amomum villosum, 1-15 parts of fennel, 5-20 parts of Linderae umbellatae, 15-35 parts of Polygonum multiflorum vine, 15-35 parts of Albizzia julibrissin bark, 5-25 parts of Salvia miltiorrhizae, 5-20 parts of Magnolia officinalis bark, 5-20 parts of stir-fried Citrus aurantium with bran, 10-25 parts of stir-fried Radish seeds, 5-25 parts of Poria cocos, 10-25 parts of Atractylodes macrocephala, 1-15 parts of Pinellia ternata, 1-15 parts of Citrus reticulata peel, 1-15 parts of Bombyx batryticatus, 10-25 parts of stir-fried malt, 1-15 parts of cinnamon twig, 5-25 parts of white peony root, 5-20 parts of vinegar-sweetened Cyperus rotundus, and 1-15 parts of roasted Licorice root.

2. The Chinese medicine composition for treating migraine according to claim 1, characterized in that: The invention comprises the following medicinal raw materials in parts by weight: 7-18 parts of Gastrodia elata, 7-18 parts of Corydalis yanhusuo, 7-18 parts of Artemisia rapa, 7-18 parts of Codonopsis pilosula, 3-13 parts of Amomum villosum, 3-13 parts of fennel, 7-18 parts of Linderae umbellatae, 17-33 parts of Polygonum multiflorum, 17-33 parts of Albizzia julibrissin, 7-23 parts of Salvia miltiorrhizae, 7-18 parts of Magnolia officinalis bark, 7-18 parts of stir-fried Citrus aurantium with bran, 12-23 parts of stir-fried Radish seeds, 7-23 parts of Poria cocos, 12-23 parts of Atractylodes macrocephala, 3-13 parts of Pinellia ternata, 3-13 parts of Citrus reticulata peel, 3-13 parts of Bombyx batryticatus, 12-23 parts of stir-fried malt, 3-13 parts of cinnamon twig, 7-23 parts of white peony root, 7-18 parts of Cyperus rotundus with vinegar, and 3-13 parts of roasted Licorice root.

3. The Chinese medicine composition for treating migraine according to claim 1, characterized in that: The invention comprises the following medicinal raw materials in proportion by weight: 10-15 parts of Gastrodia elata, 10-15 parts of Corydalis yanhusuo, 10-15 parts of Artemisia argyi, 10-15 parts of Codonopsis pilosula, 5-10 parts of Amomum villosum, 5-10 parts of fennel, 10-15 parts of Linderae strychnifolia, 20-30 parts of Polygonum multiflorum vine, 20-30 parts of Albizzia julibrissin bark, 10-20 parts of Salvia miltiorrhiza, 10-15 parts of Magnolia officinalis bark, 10-15 parts of stir-fried Citrus aurantium with bran, 15-20 parts of stir-fried Radish seeds, 10-20 parts of Poria cocos, 15-20 parts of Atractylodes macrocephala, 5-10 parts of Pinellia ternata, 5-10 parts of Citrus reticulata peel, 5-10 parts of Bombyx batryticatus, 15-20 parts of stir-fried malt, 5-10 parts of cinnamon twig, 10-20 parts of white peony root, 10-15 parts of vinegar-scented Cyperus rotundus, and 5-10 parts of roasted Licorice root.

4. Use of the Chinese medicinal composition for treating migraine according to any one of claims 1 to 3 in the preparation of a medicament for treating migraine.

5. A drug for treating migraine, characterized in that: The invention comprises the Chinese medicine composition for treating migraine according to any one of claims 1 to 3 and pharmaceutically acceptable excipients.

6. The drug for treating migraine according to claim 5, characterized in that: The dosage form of the medicine is Chinese medicine decoction, decoction, granules, pills, paste, capsules, tablets, tea, suspension, powder or oral solution.

7. The method for preparing the drug for treating migraine according to claim 5 or 6, characterized in that: The medicine is a Chinese medicine decoction, and its preparation method is as follows: Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly; Step 2, add 6 to 8 times the volume of the raw material medicine taken in step 1 of clean water and soak for 30 to 50 minutes, then boil with high heat, then continue to decoct with low heat for 30 to 45 minutes, filter with a Chinese medicine sieve to obtain a first filtrate; then add water to the residue to cover the residue, boil with high heat, then continue to decoct with low heat for 30 to 45 minutes, use a Chinese medicine sieve to filter out the residue to obtain a second filtrate; combine the first filtrate and the second filtrate to obtain a Chinese medicine decoction.

8. The method for preparing the drug for treating migraine according to claim 5 or 6, characterized in that: The medicine is an ointment, and its preparation method is as follows: Step 1, weighing the raw materials according to the weight ratio, cleaning, drying, cutting, crushing, sieving, and mixing evenly; Step 2, adding 6 to 8 times the volume of the raw material medicine obtained in step 1 into water and soaking for 30 to 50 minutes, then boiling over high heat, then changing to low heat and continuing to decoct for 30 to 45 minutes, filtering with a Chinese medicine sieve to obtain a first filtrate; then adding water to the drug residue to cover the drug residue, boiling over high heat, changing to low heat and continuing to decoct for 30 to 45 minutes, filtering out the drug residue with a Chinese medicine sieve to obtain a second filtrate; combining the first filtrate and the second filtrate; Step three, simmer the combined filtrate of step two at 100-120° C. over low heat with constant stirring, and when the drug is thick, pour the ointment into a dry container to obtain an ointment.

Images