Indwelling type nanometer micro catheter targeted positioning thrombus interventional diagnosis and treatment monitoring system and method

Abstract

The invention relates to a thrombus interventional diagnosis and treatment monitoring system and a thrombus interventional diagnosis and treatment monitoring method based on targeted positioning of an indwelling nano micro catheter, and belongs to the technical field of medical instruments. The thrombus interventional diagnosis and treatment monitoring system and the thrombus interventional diagnosis and treatment monitoring method based on targeted positioning of the indwelling type nano micro catheter comprise the steps of preoperative preparation, wherein corresponding preoperative preparation work is appointed according to the corresponding condition of a patient; performing intraoperative anesthesia: selecting a corresponding anesthesia mode according to the operation property and the health condition of the patient; blood vessel puncture: conveying the indwelling nano micro catheter to a corresponding position in the blood vessel of the patient by adopting a blood vessel puncture mode; carrying out targeted positioning; the design of a micro-catheter material with an inner layer and an outer layer which are of a double-wall type carbon nanostructure with controllable pressure infiltration is adopted, the pore diameter of carbon fibers is moderately increased and reduced by regulating and controlling the pressure of liquid medicine of the indwelling micro-catheter, local high-concentration continuous administration treatment can be achieved, the curative effect is improved, and the treatment cost is reduced. And particularly, an effective means is provided for maintaining the subsequent drug effect after interventional therapy such as operation and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an indwelling nano-microcatheter targeted positioning thrombosis intervention diagnosis and treatment monitoring system and method. Background Art

[0002] Targeted interventional diagnosis and treatment mainly uses imaging technology (such as X-ray, CT, ultrasound or MRI, etc.) for precise positioning, and delivers an indwelling nano-microcatheter into the lesion site in the body through percutaneous puncture or vascular puncture, and then the drug solution, treatment equipment, etc. can quickly reach the lesion site through the indwelling nano-microcatheter and treat it. At present, targeted interventional diagnosis and treatment is often used for localized diseases such as thrombosis.

[0003] Since the existing indwelling nano-microcatheters have a single function, medical staff need to insert multiple indwelling nano-microcatheters to perform detection, treatment, collection, monitoring and other operations during targeted interventional diagnosis and treatment. This will not only increase the trauma of the patients, but also increase the burden on medical staff. Summary of the invention

[0004] Based on this, it is necessary to provide an indwelling nano-microcatheter targeted thrombosis interventional diagnosis and treatment monitoring system and method to address the problems of fewer functions and poor treatment and monitoring effects in existing targeted interventional diagnosis and treatment methods.

[0005] The indwelling nano-microcatheter targeted positioning thrombosis interventional diagnosis and treatment monitoring method comprises: Preoperative preparation: specify the corresponding preoperative preparation tasks according to the patient's corresponding conditions; Intraoperative anesthesia: Choose the appropriate anesthesia method based on the nature of the surgery and the patient's health condition; Vascular puncture: The indwelling nano-microcatheter is delivered to the corresponding position in the patient's blood vessels by vascular puncture; Targeted positioning: contrast agent is injected through an indwelling nano-microcatheter, and imaging technology is used to observe the specific location and severity of the lesion; Interventional treatment and diagnosis and treatment monitoring: According to the characteristics and location of the lesion, select the appropriate interventional treatment method, and use the indwelling nano-microcatheter to perform treatment, regularly locate and collect drug efficacy samples, and test the patient's blood indicators; Blood testing: Perform multiple tests on blood samples to improve the specificity and anti-interference of target detection in blood samples.

[0006] Furthermore, the interventional treatment and diagnosis and treatment monitoring: according to the characteristics and location of the lesion, select the appropriate interventional treatment method, and use the indwelling nano-microcatheter for treatment, regularly locate and collect drug efficacy samples, and detect the patient's blood indicators including: Interventional treatment: Use a circulating syringe to inject the drug solution into the indwelling nano-microcatheter drug-guiding cavity, and increase the hydraulic pressure inside the indwelling nano-microcatheter drug-guiding cavity to more than 150 mmHg. The pore size of the inner and outer layers of the indwelling nano-microcatheter carbon fiber will expand accordingly, allowing the drug solution solute to be slowly released to the outside of the indwelling nano-microcatheter; Diagnosis and treatment monitoring: Before drawing blood samples, it is necessary to draw the front blood sample and return it to the blood vessel outside the microcatheter through the circulating syringe to ensure that it is not disturbed by residual drug solution. Then adjust the pushing direction of the circulating syringe, and connect the circulating syringe to the suction and retention nano-microcatheter sampling cavity. Then use the negative pressure of the circulating syringe to draw the blood sample in the retention nano-microcatheter sampling cavity.

[0007] Furthermore, the blood test: performing multiple tests on the blood sample to improve the specificity and anti-interference of the target detection of the blood sample includes: The blood sample is first introduced into the blood index detector, and the corresponding components in the blood are electronically induced to generate data of different impedance spectra. The concentration of the blood sample components is automatically calculated by the instrument computer through comparison and subtraction with the impedance of normal body samples or the background of the body when not taking drugs, as well as comparison with the standard impedance data of known standard components. When there are suspected interferences in the sample, the blood index detector is used as a subsystem, and the same suspected sample and carrier that have been tested are inserted into the detector mother system with ultraviolet spectrophotometric identification function for optical feature identification test, and buffer dilution re-test test when necessary; By connecting to big data computer software systems, such as clinical imaging examinations, cardiovascular and cerebrovascular function instrument evaluations, patient medical histories, diagnostic data, auxiliary and differential diagnosis test results, etc., we can further improve and make accurate health assessments and efficacy monitoring.

[0008] The indwelling nano-microcatheter targeted positioning thrombosis interventional diagnosis and treatment monitoring system comprises: A guiding module, wherein the guiding module comprises an indwelling nano-microcatheter, wherein the indwelling nano-microcatheter comprises a composite tube body, wherein the inner and outer wall layers of the composite tube body are provided with a carbon fiber single-layer structure that can be regulated by pressure and osmosis, and the two inner carbon fiber single-layer structures respectively constitute a drug guiding cavity and a sampling cavity; a treatment and sampling module, the treatment and sampling module comprising a circulating syringe, the circulating syringe comprising a disposable syringe and a rotatable syringe head; The detection and monitoring module includes a blood index detector anti-interference system and a blood index monitoring software system.

[0009] Furthermore, the composite tube body is made of disposable carbon fiber nanomaterial, and the overall length specifications of the indwelling nano-microcatheter are 0.5m, 1.0m, 1.5m and 2.0m respectively.

[0010] Furthermore, spirally wound and mesh-distributed copper filaments are provided between the inner and outer wall layers of the composite pipe body for fusion support and filling.

[0011] Furthermore, the carbon fiber single-layer structure is a polymer material with a hexagonal molecular structure of carbon fiber, the adjustable carbon fiber material has a nanopore size of 1~50nm, and controllable pressure penetration; the inner diameter of the inner wall of the microcatheter is 2.0mm, the outer diameter of the inner outer wall is 2.3mm, the inner diameter of the outer inner wall is 2.7mm, and the outer diameter of the outer outer wall is 3.0mm.

[0012] Furthermore, the front port of the indwelling nano-microcatheter is provided with a unidirectional carbon fiber nano-flap, the cross-sectional shape of the unidirectional carbon fiber nano-flap is elliptical, and the length of the unidirectional carbon fiber nano-flap is greater than the inner diameter of the front port of the indwelling nano-microcatheter.

[0013] Furthermore, the starting end of the composite tube body is provided with two sealing covers, and the two sealing covers are respectively inserted into the inside of the drug guiding cavity and the sampling cavity.

[0014] Furthermore, the blood index detector anti-interference system includes a blood index detector, an ultraviolet spectrophotometer and an automatic diluter, wherein the ultraviolet spectrophotometer is a parent system, the blood index detector is a subsystem, and the automatic diluter is an optional system.

[0015] The above-mentioned indwelling nano-microcatheter targeted positioning thrombosis intervention diagnosis and treatment monitoring system and method adopts a microcatheter material design with a multi-walled carbon nanostructure with an inner and outer layer as controllable pressure osmosis, and achieves moderate expansion and reduction of the carbon fiber pore size by regulating the pressure of the drug solution of the indwelling microcatheter, so as to achieve both local high-concentration continuous drug administration treatment to improve the efficacy, especially providing an effective means to maintain the subsequent drug efficacy after interventional treatment such as surgery, and locating and collecting drug efficacy samples, monitoring blood indicators, and achieving the purpose of microcatheter self-anticoagulation by the method of controlled osmotic drug sustained release, which is conducive to the characteristic that agglutination is not easy to occur in blood vessels for a long time; The switching between infusion therapy and sampling functions can be achieved through the circulating syringe, and no blood in the body is wasted before the anti-interference sampling mid-section blood sample; The high-channel blood index detector realizes spectrum difference detection through damped electronic sensing, and is combined with an anti-interference ultraviolet spectrometer and automatic re-identification test after sample dilution to improve the specificity and anti-interference degree of sample target detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the present invention or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0017] Figure 1 It is a schematic diagram of the method flow of the present invention; Figure 2 It is a system schematic diagram of the present invention; Figure 3 is a schematic diagram of the algorithm of the blood index detector in the present invention; Figure 4 It is a cross-sectional schematic diagram of the indwelling nano-microcatheter and the puncture needle in the present invention; Figure 5 is a cross-sectional schematic diagram of a rotatable injector head in the present invention; Figure 6 Schematic diagram of the expansion of carbon fiber pore size in the present invention; Figure 7 Schematic diagram of the shrinkage of the carbon fiber pore size in the present invention; Figure 8 Schematic diagram of the position of the unidirectional carbon fiber nano-petals in the present invention.

[0018] Reference numerals: 100. Guidance module; 200. Treatment and sampling module; 300. Blood testing module. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of the present invention are for illustrative purposes only and do not represent the only implementation method.

[0021] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0022] In the present invention, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediate medium. Moreover, a first feature being “above”, “above” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0023] Unless otherwise defined, all technical and scientific terms used in the specification of the present invention have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used in the specification of the present invention includes any and all combinations of one or more related listed items.

[0024] Combine the following Figure 1 - Figure 8 The invention describes the indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system and method.

[0025] In one embodiment, Figure 1 As shown, the indwelling nano-microcatheter targeted positioning thrombosis interventional diagnosis and treatment monitoring method comprises: S1: Preoperative preparation: Patient assessment: Conduct a comprehensive assessment of the patient to confirm whether his or her physical condition is suitable for interventional treatment, which includes understanding the patient's medical history, conducting necessary physical examinations and laboratory tests; Preoperative preparation: Depending on the needs of the surgery, the patient may need to undergo a series of preoperative preparations such as fasting, abstaining from water, skin preparation, and indwelling catheterization; S2: Intraoperative Anesthesia: When patients need relatively simple interventional treatment, local anesthesia can be used. When interventional treatment is required for a longer time or is more complicated, general anesthesia is used. The specific situation needs to be based on the nature of the patient's surgery and the patient's health status. S3: Vascular puncture: Selection of puncture site: Commonly used puncture sites are the femoral artery or radial artery; Local anesthesia: Local anesthesia is administered to the puncture area as needed to relieve pain; Puncture operation: Connect the puncture needle to the indwelling targeted positioning microcatheter in advance, and then insert the puncture needle into the artery and guide it to the lesion site.

[0026] S4: Targeting: Contrast agents are injected through an indwelling nano-microcatheter, and imaging technology is used to target and observe the specific location and severity of the lesion; S5: Interventional treatment: The drug solution is injected into the drug delivery cavity of the indwelling nano-microcatheter using a circulating syringe, and the hydraulic pressure inside the drug delivery cavity of the indwelling nano-microcatheter is increased to greater than 150 mmHg, and the pore size of the carbon fibers in the inner and outer layers of the indwelling nano-microcatheter is enlarged accordingly, so that the drug solution solute is slowly released to the outside of the indwelling nano-microcatheter; S6: Diagnosis and treatment monitoring: Before drawing blood samples, it is necessary to draw blood samples from the front end and return them to the blood vessels outside the microcatheter through the circulation syringe to ensure that they are not interfered by residual liquid medicine. Then, the pushing direction of the circulation syringe is adjusted, and the circulation syringe is connected to the sampling cavity of the suction and retention nano-microcatheter. Then, the blood samples in the sampling cavity of the retention nano-microcatheter are sucked by the negative pressure of the circulation syringe. S7: Blood test: The blood sample is first introduced into the blood index detector, and the corresponding components in the blood are electronically induced to generate data of different impedance spectra. The concentration of the blood sample components is automatically calculated by the instrument computer through comparison and subtraction with the impedance of normal body samples or the background of the body when not taking drugs, as well as comparison with the standard impedance data of known standard components. When there are suspected interferences in the sample, the blood index detector is used as a subsystem, and the same suspected sample and carrier that have been tested are inserted into the detector mother system with ultraviolet spectrophotometric identification function for optical feature identification test, and buffer dilution re-test test when necessary; By connecting to big data computer software systems, such as clinical imaging examinations, cardiovascular and cerebrovascular function instrument evaluations, patient medical histories, diagnostic data, auxiliary and differential diagnosis test results, etc., we can further improve and make accurate health assessments and efficacy monitoring.

[0027] As the instruction manual Figure 2-8 As shown, the indwelling nano-microcatheter targeted positioning thrombosis interventional diagnosis and treatment monitoring system includes: The guiding module 100 includes an indwelling nano-microcatheter, which includes a composite tube body. The inner and outer wall layers of the composite tube body are provided with a carbon fiber single-layer structure that can be adjusted with pressure and osmosis. The two inner carbon fiber single-layer structures respectively form a drug guiding cavity and a sampling cavity. When the drug guiding fluid pressure increases to a certain level (blood pressure>150mmHg), the pore size of the carbon fiber in the inner and outer layers of the microcatheter expands accordingly, so that the drug solution solute is slowly released outside the tube, thereby enhancing the self-anticoagulant effect of the long-term indwelling microcatheter; on the contrary, when the sampling pressure decreases to a certain level (blood pressure<50mmHg), the carbon fiber pore size is in a closed state, thereby ensuring the true accuracy of the sampling index at the target location; After production, indwelling nano-microcatheters need to undergo sterility, non-toxicity, and non-immunosuppression tests and product performance verification. As a Class III medical device, active animal experiments and clinical verification must be fully qualified before they can be released from the factory and put on the market. See the instruction manual Figure 6 ,This figure shows that when the infusion osmotic pressure is greater than 150 mmHg, the pore size of the carbon fiber slightly expands to 2~50 nm; See the instruction manual Figure 7 ,This figure shows that when the microcatheter target is sampled, when the pressure inside the microcatheter is less than 50 mmHg, the pore size of the carbon fiber is reduced to less than 2 mm; The material of the composite tube body is disposable carbon fiber nanomaterial. By controlling the pressure of the drug solution and adjusting the difference in the size of the carbon fiber nanopores between the formed components of the blood and the injected drug solutes (the closed pore size of the carbon fiber in the wall layer of the microcatheter during sampling is <2nm; the expanded pressure-osmotic pore size of the carbon fiber in the wall layer of the microcatheter during drug delivery is ∈[2, 50]nm), it is possible to collect local target blood drug concentrations from the microcatheter for testing when the drug is stopped, and to enhance the anticoagulant effect of the catheter itself through the anticoagulant drugs that slowly and controllably seep out of the nanopores of the microcatheter during drug administration, thereby avoiding the risk of coagulation caused by long-term retention of the microcatheter in the blood vessel.

[0028] Spiral winding and mesh-distributed copper filament fusion support and filling are arranged between the inner and outer wall layers of the composite tube body to ensure a certain ability of passing and extending within the blood vessel.

[0029] The carbon fiber single-layer structure is a polymer material with a hexagonal molecular structure of carbon fiber. The nanopore size of the carbon fiber material can be adjusted from 1 to 50 nm, and the pressure penetration can be controlled. The inner diameter of the inner wall of the microcatheter is 2.0 mm, the outer diameter of the inner outer wall is 2.3 mm, the inner diameter of the outer inner wall is 2.7 mm, and the outer diameter of the outer outer wall is 3.0 mm.

[0030] The overall length specifications of the indwelling nano-microcatheter are 0.5m, 1.0m, 1.5m and 2.0m respectively.

[0031] The starting end of the composite tube body is provided with two sealing caps, which are respectively inserted into the inside of the drug guiding cavity and the sampling cavity to seal the blood from overflowing during the non-drug delivery and sampling periods.

[0032] See the instruction manual Figure 8 In the figure, a unidirectional carbon fiber nanoflap is provided inside the front port of the indwelling nano-microcatheter. The cross-sectional shape of the unidirectional carbon fiber nanoflap is elliptical. The unidirectional carbon fiber nanoflap is in an inclined state at this time, and the inclination angle is far away from the front port of the indwelling nano-microcatheter. The length of the unidirectional carbon fiber nanoflap is greater than the inner diameter of the front port of the indwelling nano-microcatheter. When the indwelling nano-microcatheter is used for infusion therapy into the patient's body, the unidirectional carbon fiber nanoflap is at the position of the solid line ellipse at this time. The unidirectional carbon fiber nanoflap is pressed against the inside of the front port of the indwelling nano-microcatheter due to the hydraulic pressure, so that the unidirectional carbon fiber nanoflap blocks the front port of the indwelling nano-microcatheter, prevents the drug solution from being directly discharged from the indwelling nano-microcatheter, ensures that the drug solution seeps out through the nano-micropores, and achieves local high-concentration therapy. When the blood sample in the patient's body is sampled by negative pressure through the indwelling nano-microcatheter, the unidirectional carbon fiber nanoflap is at the position of the dotted line ellipse at this time, which can create a sufficient gap between the unidirectional carbon fiber nanoflap and the front port of the indwelling nano-microcatheter to ensure that the blood sample is quickly drawn out for inspection.

[0033] See the instruction manual Figure 4 The outermost dotted circle in the figure is the cross-section of the bottom of the indwelling puncture needle, the solid circle next to the inner side of the outermost dotted circle is the cross-section of the cover at the beginning of the indwelling nano-microcatheter, the dotted circles marked A1 and A3 are the normal sealing positions of the injection head drug sample rotation, the solid circle marked A2 is the position of the drug sample inlet and outlet hole, and the solid circle marked A4 is the position of the entry hole in the blood vessel outside the catheter.

[0034] See the instruction manual Figure 5 The outermost solid circle in the figure is the cross section of the rotatable syringe head, the dotted circles marked as B1 and B3 are the injection head drug sample rotation normally sealed positions, the solid circle marked as B2 is the inlet and outlet position of the indwelling nano-microcatheter drug sample, and the solid circle marked as B4 is the inlet position of the indwelling nano-microcatheter outside the blood vessel; Among them, A1 and B1 are connected with each other, A2 and B2 are connected with each other, A3 and B3 are connected with each other, and A4 and B4 are connected with each other.

[0035] The treatment and sampling module 200 includes a circulating syringe, which includes a disposable syringe and a rotatable syringe head; The following points should be noted when using the circulating syringe: (1) When infusing the drug solution, the blood circulating outside the microcatheter is allowed to be drawn through the circulation syringe and then returned to the microcatheter, where it is mixed with the drug solution to increase its pressure, so as to ensure that the pore size of the carbon fiber of the microcatheter reaches a micro-osmotic anticoagulant state.

[0036] (2) Before drawing blood samples, it is necessary to draw blood from the front end and return it to the blood vessel outside the microcatheter through a circulating syringe to ensure that it is not interfered by residual drug solution.

[0037] The detection and monitoring module 300 includes a blood index detector anti-interference system and a blood index monitoring software system.

[0038] The blood index detector anti-interference system includes a blood index detector, an ultraviolet spectrophotometer and an automatic diluter, wherein the ultraviolet spectrophotometer is a parent system, the blood index detector is a subsystem, and the automatic diluter is an optional system; Principle of blood index detector: This method adopts an electronic damping inductive high-channel POCT detection method for multiple blood indexes. When the blood sample enters the detector through the microcatheter inlet valve, various tangible and intangible components in the blood are electronically induced to generate data of different impedance spectra. By comparing and subtracting the impedance of normal body samples or the background of the body when not taking drugs, and comparing with the standard impedance data of known standard components, the instrument computer automatically calculates the concentration of many components in the blood sample; See the instruction manual Figure 3 The different inner diameters of particles 1 number 1, particle 2 number 1, particle 2 number 2, particle 1 number 2, and particle 2 number 3 passing through the detection point at time t respectively result in different resistance peak values ​​R. By measuring the particles with the same inner diameter and resistance peak passing through the detection point at time t, the content or concentration of the particles of the substance can be calculated (the inner diameter and resistance value of the measured particles are required to be consistent or close to the inner diameter and resistance peak of the known standard); Ro is the resistance peak of the possible interference, and Rf is the resistance peak of the test object. Interference can be appropriately eliminated through the calculation program.

[0039] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0040] The above-described embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for a person of ordinary skill in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A method for monitoring interventional diagnosis and treatment of thrombosis by targeting and positioning a dangling nano-microcatheter, characterized in that: The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring method comprises: Preoperative preparation: specify the corresponding preoperative preparation tasks according to the patient's corresponding conditions; Intraoperative anesthesia: Choose the appropriate anesthesia method based on the nature of the surgery and the patient's health condition; Vascular puncture: The indwelling nano-microcatheter is delivered to the corresponding position in the patient's blood vessels by vascular puncture; Targeted positioning: contrast agent is injected through an indwelling nano-microcatheter, and imaging technology is used to observe the specific location and severity of the lesion; Interventional treatment and diagnosis and treatment monitoring: According to the characteristics and location of the lesion, select the appropriate interventional treatment method, and use the indwelling nano-microcatheter to perform treatment, regularly locate and collect drug efficacy samples, and test the patient's blood indicators; Blood testing: Perform multiple tests on blood samples to improve the specificity and anti-interference of target detection in blood samples.

2. The method for monitoring thrombosis intervention with targeted positioning of an indwelling nano-microcatheter according to claim 1, characterized in that: The interventional treatment and diagnosis and treatment monitoring: according to the characteristics and location of the lesion, select the appropriate interventional treatment method, and use the indwelling nano-microcatheter to perform the treatment, regularly locate and collect drug efficacy samples, and test the patient's blood indicators, including: Interventional treatment: Use a circulating syringe to inject the drug solution into the indwelling nano-microcatheter drug-guiding cavity, and increase the hydraulic pressure inside the indwelling nano-microcatheter drug-guiding cavity to more than 150 mmHg. The pore size of the inner and outer layers of the indwelling nano-microcatheter carbon fiber will expand accordingly, allowing the drug solution solute to be slowly released to the outside of the indwelling nano-microcatheter; Diagnosis and treatment monitoring: Before drawing blood samples, it is necessary to draw the front blood sample and return it to the blood vessel outside the microcatheter through the circulating syringe to ensure that it is not disturbed by residual drug solution. Then adjust the pushing direction of the circulating syringe, and connect the circulating syringe to the suction and retention nano-microcatheter sampling cavity. Then use the negative pressure of the circulating syringe to draw the blood sample in the retention nano-microcatheter sampling cavity.

3. The method for monitoring thrombosis intervention with targeted positioning of an indwelling nano-microcatheter according to claim 1, characterized in that: The blood test: performing multiple tests on blood samples to improve the specificity and anti-interference of target detection in blood samples includes: The blood sample is first introduced into the blood index detector, and the corresponding components in the blood are electronically induced to generate data of different impedance spectra. The concentration of the blood sample components is automatically calculated by the instrument computer through comparison and subtraction with the impedance of normal body samples or the background of the body when not taking drugs, as well as comparison with the standard impedance data of known standard components. When there are suspected interferences in the sample, the blood index detector is used as a subsystem, and the same suspected sample and carrier that have been tested are inserted into the detector mother system with ultraviolet spectrophotometric identification function for optical feature identification test, and buffer dilution re-test test when necessary; By connecting to big data computer software systems, such as clinical imaging examinations, cardiovascular and cerebrovascular function instrument evaluations, patient medical histories, diagnostic data, auxiliary and differential diagnosis test results, etc., we can further improve and make accurate health assessments and efficacy monitoring.

4. An indwelling nano-microcatheter targeted thrombosis interventional diagnosis and treatment monitoring system, comprising the indwelling nano-microcatheter targeted thrombosis interventional diagnosis and treatment monitoring method according to any one of claims 1 to 3, characterized in that: The indwelling nano-microcatheter targeted positioning thrombosis intervention diagnosis and treatment monitoring system comprises: A guiding module, wherein the guiding module comprises an indwelling nano-microcatheter, wherein the indwelling nano-microcatheter comprises a composite tube body, wherein the inner and outer wall layers of the composite tube body are provided with a carbon fiber single-layer structure that can be regulated by pressure and osmosis, and the two inner carbon fiber single-layer structures respectively constitute a drug guiding cavity and a sampling cavity; a treatment and sampling module, the treatment and sampling module comprising a circulating syringe, the circulating syringe comprising a disposable syringe and a rotatable syringe head; The detection and monitoring module includes a blood index detector anti-interference system and a blood index monitoring software system.

5. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4 is characterized in that: The composite tube body is made of disposable carbon fiber nanomaterial, and the overall length specifications of the indwelling nano-microcatheter are 0.5m, 1.0m, 1.5m and 2.0m respectively.

6. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4 is characterized in that: Spiral winding and mesh-distributed copper filament fusion support and filling are arranged between the inner and outer wall layers of the composite pipe body.

7. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4 is characterized in that: The carbon fiber single-layer structure is a polymer material with a hexagonal molecular structure of carbon fiber. The adjustable carbon fiber material has a nanopore size of 1-50nm and controllable pressure penetration. The inner diameter of the inner wall of the microcatheter is 2.0mm, the outer diameter of the inner outer wall is 2.3mm, the inner diameter of the outer inner wall is 2.7mm, and the outer diameter of the outer outer wall is 3.0mm.

8. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4 is characterized in that: The front port of the indwelling nano-microcatheter is provided with a unidirectional carbon fiber nano-flap, the cross-sectional shape of the unidirectional carbon fiber nano-flap is elliptical, and the length of the unidirectional carbon fiber nano-flap is greater than the inner diameter of the front port of the indwelling nano-microcatheter.

9. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4 is characterized in that: The starting end of the composite tube body is provided with two sealing covers, and the two sealing covers are respectively inserted into the inside of the drug guiding cavity and the sampling cavity.

10. The indwelling nano-microcatheter targeted thrombosis intervention diagnosis and treatment monitoring system according to claim 4, characterized in that: The blood index detector anti-interference system comprises a blood index detector, an ultraviolet spectrophotometer and an automatic diluter, wherein the ultraviolet spectrophotometer is a parent system, the blood index detector is a subsystem, and the automatic diluter is an optional system.

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