Hydrogel electrode with repeated adhesion characteristic, preparation method and application thereof

Abstract

The invention discloses a hydrogel electrode with a repeated adhesion characteristic, the hydrogel electrode is prepared from a hydrophilic monomer, an initiator, a polysaccharide substance and a conductive substance through a one-pot method, and the hydrogel electrode has good adhesion characteristic, can stably exert an adhesion effect in a humid environment, and can be used for preparing the hydrogel electrode. The adhesive force for various engineering materials and biological tissues is lasting; the hydrogel electrode can be repeatedly adhered to a human body, and still has adhesiveness after being repeatedly adhered for 60 times; the hydrogel electrode disclosed by the invention has very good biocompatibility; the hydrogel electrode can be used for detecting movement conditions of fingers, wrists, knees and the like of a human body; the hydrogel electrode can be used for monitoring myoelectricity and electrocardio information of a human body and stably and continuously outputting electric signals. The hydrogel electrode capable of being repeatedly adhered disclosed by the invention has the characteristics of being simple to prepare, low in cost, capable of being repeatedly adhered, high in sensitivity, good in mechanical property, wearable and the like.

Description

Technical Field

[0001] The invention belongs to the field of polymer materials, and in particular relates to a hydrogel electrode with repeated adhesion characteristics, a preparation method and application thereof. Background Art

[0002] In today's era of rapid technological development, electrode technology, as a key support in many fields, is facing an urgent need for continuous upgrading and innovation. From biomedical engineering to energy storage and conversion, to intelligent sensing systems, the performance of electrodes directly affects the efficiency, stability and reliability of the entire system. When traditional metal or rigid electrodes come into contact with human tissue, they often cause a series of problems due to the mismatch between their mechanical properties and those of biological tissues. For example, long-term implantation of electrodes in the body may cause tissue inflammation, fibrosis, and even affect the normal function of peripheral nerves and cells. This not only reduces the therapeutic effect of medical devices, but may also bring additional pain and health risks to patients. In addition, in in vitro detection applications such as electromyography (EMG) and electrocardiogram (ECG), the fit between traditional electrodes and skin is not ideal, which easily generates signal interference and noise, affecting the accuracy and reliability of detection. The emergence of hydrogel materials has brought new hope for solving the above-mentioned electrode technology problems. Hydrogel is a polymer material with a three-dimensional network structure. Its high water content gives it softness and elasticity similar to biological tissues, greatly improving the adaptability of electrodes to biological tissues or other contact interfaces. In biomedical applications, hydrogel electrodes fit human tissue more closely, reducing mechanical stimulation and inflammatory response, and optimizing signal acquisition quality and stability.

[0003] Although hydrogel electrodes have great potential, current technology still faces many challenges. For example, hydrogel materials have poor mechanical strength and are prone to deformation and rupture in practical applications; the preparation process is complicated and costly, which hinders large-scale commercial promotion; in addition, many hydrogel electrodes are disposable and cannot be reused. In view of this, the research and development of hydrogel electrodes is of great significance and has broad market prospects. It is urgently needed to use patented technological innovation to break through the existing bottlenecks and promote hydrogel electrode technology to a new stage with higher performance, more stability and more cost-effectiveness, thereby meeting the urgent needs of various fields for advanced electrode materials. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a hydrogel electrode with repeated adhesion properties, so as to achieve the purposes of simple preparation, low cost, repeated adhesion, high sensitivity, good mechanical properties, and wearability.

[0005] To achieve the above object, the technical solution of the present invention is as follows:

[0006] A hydrogel electrode with repeated adhesion properties is prepared from a hydrophilic monomer, an initiator, a polysaccharide substance and a conductive substance through a one-pot method. The hydrogel electrode has good adhesion properties, can more stably exert its adhesion effect in a humid environment, and has lasting adhesion to a variety of engineering materials and biological tissues; the hydrogel electrode can be repeatedly adhered to the human body and still has adhesion after repeated adhesion for 60 times; the hydrogel electrode has good biocompatibility; the hydrogel electrode can be used to detect the activities of human fingers, wrists, knees, etc.; the hydrogel electrode can be used to monitor the body's electromyography and electrocardiogram information, and stably and continuously output electrical signals.

[0007] As a further embodiment of the invention, the hydrophilic monomer includes any one of acrylic acid, acrylamide and methacrylic acid.

[0008] As a further embodiment of the invention, the initiator includes any one of ammonium persulfate, potassium persulfate and 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone.

[0009] As a further embodiment of the invention, the polysaccharide substance includes one or more of sodium alginate, trehalose, guar gum, locust bean gum and gelatin.

[0010] As a further embodiment of the invention, the conductive material includes one or more of poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid, silver nanowires, and carbon nanotubes.

[0011] As a further embodiment of the invention, the one-pot preparation method comprises any one of a thermally initiated polymerization method and a photoinitiated polymerization method.

[0012] As a further embodiment of the invention, the preparation method of the hydrogel electrode comprises the following steps:

[0013] S1. Use a 1 / 10,000 balance to weigh the hydrophilic monomer, initiator, polysaccharide and conductive material, and add them to the beaker in sequence;

[0014] S2. Add an appropriate amount of water to the beaker, put in a magnet and place the beaker on a stirrer, select an appropriate speed and stir until a uniform solution is obtained;

[0015] S3. Use a pipette to add an appropriate amount of uniform solution into the mold;

[0016] S4. Cover the mold completely with plastic wrap and place it in an oven for reaction.

[0017] The application of hydrogel electrodes with repeated adhesion characteristics to detect the activities of human fingers, wrists, knees, etc. includes the following steps:

[0018] P1. Stick the hydrogel on any part of the human body such as fingers, wrists, elbows or knees;

[0019] P2. Connect the two ends of the hydrogel to the wires and connect them to the digital source meter.

[0020] P3. When the fingers, wrists, elbows or knees are bent, twisted, etc., the signal is transmitted to the digital source meter through the hydrogel, and the output signal of the human body activity can be obtained.

[0021] The application of the hydrogel electrode with repeated adhesion characteristics for monitoring human electrocardiogram and electromyography information includes the following steps:

[0022] P1. Stick the hydrogel to the corresponding part of the human body;

[0023] P2. Connect the hydrogel to the wire and connect it to the multi-channel physiological signal acquisition and processing system;

[0024] P3. The electromyographic or electrocardiographic signals are transmitted to the multi-channel physiological signal acquisition and processing system through the hydrogel to obtain the electromyographic or electrocardiographic information of the human body.

[0025] Compared with the prior art, the hydrogel in the present invention has the following beneficial effects:

[0026] 1. The present invention adopts a one-pot preparation method, which has a simple method, few operating steps, high preparation efficiency, and can be produced in large quantities in a short time, greatly reducing manpower and costs.

[0027] 2. The present invention has been proven to have excellent biocompatibility, is non-toxic and non-irritating, and has no risk of adverse reactions such as allergies and inflammation when in contact with human tissues, thereby protecting the health and safety of users while ensuring comfort for long-term wearing.

[0028] 3. The present invention has stable repeated adhesion, can be repeatedly adhered to the human body, and still has adhesion after repeated adhesion for 60 times, and can continuously output signals. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0030] Figure 1 A state diagram of a hydrogel electrode with repeated adhesion characteristics disclosed in an embodiment of the present invention;

[0031] Figure 2 A schematic diagram of a preparation process of a hydrogel electrode with repeated adhesion characteristics disclosed in an embodiment of the present invention;

[0032] Figure 3The application of a hydrogel electrode with repeated adhesion characteristics disclosed in an embodiment of the present invention is to detect digital photos of human fingers, wrists, knees and other activities and output signal curves;

[0033] Figure 4 The invention discloses an application of a hydrogel electrode with repeated adhesion characteristics, a digital photo of monitoring human electrocardiogram and electromyography information, and output electrocardiogram and electromyography signal curves. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0035] The present invention provides a hydrogel electrode with repeated adhesion characteristics, wherein the hydrogel electrode is composed of a hydrophilic monomer, an initiator, a polysaccharide substance and a conductive substance, and is prepared by a one-pot method;

[0036] The hydrophilic monomer includes any one of acrylic acid, acrylamide, and methacrylic acid;

[0037] The initiator includes any one of ammonium persulfate, potassium persulfate and 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone;

[0038] The polysaccharide substance includes one or more of sodium alginate, trehalose, guar gum, locust bean gum, and gelatin;

[0039] The conductive material includes one or more of poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid, silver nanowires, and carbon nanotubes;

[0040] The one-pot method includes any one of a thermally initiated polymerization and a photoinitiated polymerization method.

[0041] like Figure 1 As shown, the hydrogel electrode has good flexibility and can be bent and twisted.

[0042] like Figure 2 As shown: The preparation method of the hydrogel electrode is as follows:

[0043] S1. Use a 1 / 10,000 balance to weigh 0.5g acrylamide, 0.01g sodium alginate, 0.15g trehalose, and 0.01g ammonium persulfate and add them to a beaker in sequence;

[0044] S2. After adding 334 μL of poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid and 666 μL of water into a beaker, a magnetic bar was placed and the beaker was placed on a stirrer at a speed of 200 rpm and stirred for 2 hours until a uniform solution was obtained;

[0045] S3. Use a pipette to take 1 ml of the uniform solution and add it to the mold;

[0046] S4. Use plastic wrap to completely cover the mold and place it in a 60-degree oven for reaction for 8 hours.

[0047] like Figure 3 shown.

[0048] An application of a hydrogel electrode with repeated adhesion characteristics to detect the activities of human fingers, wrists, knees, etc. includes the following steps:

[0049] P1. Stick the hydrogel on any part of the human body such as fingers, wrists, elbows or knees;

[0050] P2. Connect the two ends of the hydrogel to the wires and connect them to the digital source meter.

[0051] P3. When the fingers, wrists, elbows or knees are bent, twisted, etc., the signal is transmitted to the digital source meter through the hydrogel, and the output signal of the human body activity can be obtained.

[0052] like Figure 4 shown.

[0053] An application of a hydrogel electrode with repeated adhesion characteristics to monitor human electrocardiogram and electromyography information includes the following steps:

[0054] P1. Stick the hydrogel to the corresponding part of the human body;

[0055] P2. Connect the hydrogel to the wire and connect it to the multi-channel physiological signal acquisition and processing system;

[0056] P3. The electromyographic or electrocardiographic signals are transmitted to the multi-channel physiological signal acquisition and processing system through the hydrogel to obtain the electromyographic or electrocardiographic information of the human body.

[0057] The present invention is inspired by the adhesion mechanism of brown algae, and a polyacrylamide / sodium alginate / trehalose / PEDOT:PSS (PSTP) hydrogel electrode for monitoring bioelectric signals is prepared. The addition of sodium alginate and trehalose makes the three-dimensional network structure of the hydrogel more compact, which can significantly improve the mechanical properties of the hydrogel, and also ensures that the PSTP hydrogel electrode has good biocompatibility. The experimental results show that the prepared PSTP hydrogel still has certain adhesion properties after repeated adhesion for 60 times, and can accurately transmit electrical signals, ensuring its reliability and efficiency in biomedical applications. In addition, the PSTP hydrogel can detect the electromyogram and electrocardiogram of the human body, monitor in real time and generate accurate electrical signals. This sensitivity enables it to effectively capture subtle changes in movement and provide accurate data feedback, so it has great potential for application in the fields of biomedicine and motion monitoring.

[0058] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A hydrogel electrode with repeated adhesion properties, characterized in that: The hydrogel electrode is composed of a hydrophilic monomer, an initiator, a polysaccharide substance and a conductive substance, and is prepared by a one-pot method.

2. The hydrogel electrode with repeated adhesion properties according to claim 1, characterized in that: The hydrophilic monomer includes any one of acrylic acid, acrylamide and methacrylic acid.

3. The hydrogel electrode with repeated adhesion properties according to claim 1, characterized in that: The initiator includes any one of ammonium persulfate, potassium persulfate and 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone.

4. The hydrogel electrode with repeated adhesion properties according to claim 1, characterized in that: The polysaccharide substance includes one or more of sodium alginate, trehalose, guar gum, locust bean gum and gelatin.

5. The hydrogel electrode with repeated adhesion properties according to claim 1, characterized in that: The conductive material includes one or more of poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid, silver nanowires, and carbon nanotubes.

6. The hydrogel electrode with repeated adhesion properties according to claim 1, characterized in that: The one-pot method includes any one of a thermally initiated polymerization and a photoinitiated polymerization method.

7. A method for preparing a hydrogel electrode with repeated adhesion properties according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Use a 1 / 10,000 balance to weigh the hydrophilic monomer, initiator, polysaccharide and conductive material, and add them to the beaker in sequence; S2. Add an appropriate amount of water to the beaker, put in a magnet and place the beaker on a stirrer, select an appropriate speed and stir until a uniform solution is obtained; S3. Use a pipette to add an appropriate amount of uniform solution into the mold; S4. Cover the mold completely with plastic wrap and place it in an oven for reaction.

8. Use of the hydrogel electrode with repeated adhesion properties described in any one of claims 1 to 6 or the hydrogel electrode prepared by the preparation method described in claim 7 in detecting the activities of human fingers, wrists, knees, etc. and monitoring human electrocardiogram and electromyography information.

Images