Thrombectomy system including roller pump actuation valve

Abstract

Thrombectomy catheters and pump assemblies for controlling the flow of effluent from a thrombectomy catheter are disclosed. One illustrative assembly may be a thrombectomy catheter (58), a pump (240), a connection manifold assembly (62) positioned between the thrombectomy catheter and the pump, an effluent return tube (66) fluidly coupled to the thrombectomy catheter and the connection manifold assembly, an effluent collection bag (28), an effluent waste tube (68) fluidly coupled to the connection manifold assembly and the effluent collection bag; and a spool valve (400) positioned in series with the effluent waste tube.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of priority to U.S. Provisional Application Serial No. 63 / 413,054, filed on October 4, 2022, and U.S. Provisional Application Serial No. 63 / 455,182, filed on March 28, 2023, the disclosures of which are incorporated herein by reference. Technical Field

[0003] The present invention relates to thrombectomy systems. More particularly, the present invention relates to a valve, such as a spool valve, for controlling the flow of effluent from a patient through a thrombectomy system. Background Art

[0004] Thrombectomy is a procedure for removing a thrombus from a patient's vascular system. Mechanical and fluid-based systems can be used to remove a thrombus. In the case of a fluid-based system, an infusion fluid can be injected into a treatment area of ​​a blood vessel using a catheter to dislodge the thrombus. In some cases, effluent (e.g., infusion fluid and / or blood) including the dislodged thrombus can be extracted from the blood vessel by a catheter. In known thrombectomy systems and methods, there is a continuing need to provide alternative configurations for thrombectomy catheters and systems, as well as methods of operating such thrombectomy systems. Summary of the invention

[0005] The present invention provides design, material, manufacturing method and use alternatives for medical devices.

[0006] In a first example, a thrombectomy catheter and pump assembly may include a thrombectomy catheter, a pump, a connecting manifold assembly positioned between the thrombectomy catheter and the pump, an effluent return tube fluidly coupled to the thrombectomy catheter and the connecting manifold assembly, an effluent collection bag, an effluent waste tube fluidly coupled to the connecting manifold assembly and the effluent collection bag, and a valve positioned in series with the effluent waste tube.

[0007] Alternatively or additionally to any of the above examples, in another example, the valve can be configured to selectively allow effluent to flow from the thrombectomy catheter to an effluent collection bag during use of the thrombectomy catheter.

[0008] Alternatively or additionally to any of the above examples, in another example, the valve may be a spool valve including a valve body defining an inner cavity and a valve core movably disposed within the inner cavity.

[0009] Alternatively or additionally to any of the above examples, in another example, the valve core may further include an annular groove extending around a circumference of the valve core, the annular groove being positioned between the first end of the valve core and the second end of the valve core.

[0010] Alternatively or additionally to any of the above examples, in another example, the sliding valve may include an effluent inlet port fluidly coupled to an effluent waste tube downstream of the connection manifold assembly; and an effluent outlet port fluidly coupled to the effluent waste tube upstream of the effluent collection bag.

[0011] Alternatively or additionally to any of the above examples, in another example, the effluent inlet port and the effluent outlet port may be positioned on opposite sides of the valve body.

[0012] Alternatively or additionally to any of the above examples, in another example, the valve further includes a first O-ring and a second O-ring positioned between an outer surface of the valve core and an inner surface of the valve body, wherein when the valve is in a closed configuration, the effluent inlet port is positioned between the first O-ring and the second O-ring.

[0013] Alternatively or additionally to any of the above examples, in another example, when the valve is in an open position, the effluent inlet port and the effluent outlet port can be in fluid communication with the inner cavity of the valve body. When the valve is in a closed position, the effluent inlet port and the effluent outlet port can be fluidly isolated from the inner cavity of the valve body.

[0014] Alternatively or additionally to any of the above examples, in another example, when the annular groove of the valve core is aligned with the effluent inlet port and the effluent outlet port, the effluent inlet port and the effluent outlet port can be in fluid communication with the inner cavity of the valve body.

[0015] Alternatively or additionally to any of the above examples, in another example, the spool valve may include a fluid inlet port and a fluid inlet tube extending from a first end fluidly coupled to the fluid inlet port to a second end configured to be fluidly coupled to a fluid source.

[0016] Alternatively or additionally to any of the above examples, in another example, the middle portion of the fluid inlet tube can be configured to be positioned within a roller pump of a thrombectomy catheter system drive unit. Fluid flow through the fluid inlet tube can be configured to move the valve core from a first closed configuration to a second open configuration. When the valve core is in the second open configuration, effluent flows freely from the thrombectomy catheter to the effluent collection bag; and when the valve core is in the first closed configuration, flow of effluent from the thrombectomy catheter to the effluent collection bag can be blocked.

[0017] Alternatively or additionally to any of the above examples, in another example, the spool valve may include a fluid inlet port.

[0018] Alternatively or additionally to any of the above examples, in another example, the assembly may further include a fluid inlet tube extending from a first end fluidly coupled to the fluid inlet port to a second end configured to be fluidly coupled to a fluid source.

[0019] Alternatively or additionally to any of the above examples, in another example, the intermediate portion of the fluid inlet tube can be configured to be positioned within a roller pump of a thrombectomy catheter system drive unit.

[0020] Alternatively or additionally to any of the above examples, in another example, the assembly may further include a fluid inlet tube in fluid communication with the interior of the valve. When the valve is in the open position, fluid passing through the fluid inlet tube into the interior of the valve may actuate the valve from the closed position to the open position and may allow the flow of effluent from the thrombectomy catheter to the effluent collection bag, and when the valve is in the closed position, may prevent the flow of effluent from the thrombectomy catheter to the effluent collection bag.

[0021] Alternatively or additionally to any of the above examples, in another example, the valve can be a sliding valve, which includes a valve core that can move between an open position and a closed position. The fluid entering the valve interior through the fluid inlet pipe can be configured to move the valve core from the closed position to the open position.

[0022] Alternatively or additionally to any of the above examples, in another example, the valve can include an effluent inlet port that is fluidly coupled to an effluent waste tube downstream of the connection manifold assembly, and an effluent outlet port that is fluidly coupled to the effluent waste tube upstream of the effluent collection bag. When the valve is in an open position, effluent can flow freely from the thrombectomy catheter to the effluent collection bag, and when the valve is in a closed position, effluent can be blocked from flowing from the thrombectomy catheter to the effluent collection bag.

[0023] Alternatively or additionally to any of the above examples, in another example, the valve may include a fluid inlet port in fluid communication with a fluid inlet tube extending from the valve. Pressurized fluid within the fluid inlet tube may actuate the valve from a closed position to an open position.

[0024] Alternatively or additionally to any of the above examples, in another example, the effluent inlet port and the effluent outlet port may extend at a substantially orthogonal angle to each other.

[0025] Alternatively or additionally to any of the above examples, in another example, the assembly may further include one or more holes extending from the outer surface to the inner surface of the valve core.

[0026] Alternatively or additionally to any of the above examples, in another example, the assembly may further include a plurality of O-rings positioned between an outer surface of the valve core and an inner surface of the valve body.

[0027] Alternatively or additionally to any of the above examples, in another example, when the valve is in a closed configuration, at least one of the plurality of O-rings can be positioned proximate a first side of the effluent inlet port, and a second of the plurality of O-rings can be positioned proximate a second side of the effluent inlet port.

[0028] Alternatively or additionally to any of the above examples, in another example, the assembly may further include first and second O-rings positioned between an outer surface of the valve core and an inner surface of the valve body.

[0029] Alternatively or additionally to any of the above examples, in another example, when the valve is in the closed configuration, the effluent inlet port is positioned between the first and second O-rings.

[0030] Alternatively or additionally to any of the above examples, in another example, the assembly may further include a fluid outlet port.

[0031] Alternatively or additionally to any of the above examples, in another example, the fluid outlet port may be in fluid communication with the fluid inlet port.

[0032] Alternatively or additionally to any of the above examples, in another example, the fluid outlet port can be configured to selectively allow flow of fluid from the fluid inlet port to an auxiliary collection bag during use of the thrombectomy catheter.

[0033] Alternatively or additionally to any of the above examples, in another example, the fluid outlet port may extend to the valve body in line with the longitudinal axis.

[0034] Alternatively or additionally to any of the above examples, in another example, the effluent outlet port may extend to the valve body in line with the longitudinal axis.

[0035] In another example, a thrombectomy catheter and pump assembly may include a thrombectomy catheter, a pump, a connection manifold assembly positioned between the thrombectomy catheter and the pump, an effluent return tube fluidly coupled to the thrombectomy catheter and the connection manifold assembly, an effluent collection bag, an effluent waste tube fluidly coupled to the connection manifold assembly and the effluent collection bag, and a slide valve positioned in series with the effluent waste tube. The slide valve may include a valve body, an effluent inlet port fluidly coupled to a first portion of the effluent waste tube, an effluent outlet port fluidly coupled to a second portion of the effluent waste tube, a fluid inlet port (the fluid inlet being at least substantially fluidly isolated from the effluent inlet port and the effluent outlet port), and a valve core movably disposed within an inner cavity of the valve body. The valve core may be configured to move between a closed configuration and an open configuration, the closed configuration being configured to fluidly isolate the effluent inlet port and the effluent outlet port from each other, and the open configuration being configured to fluidly couple the effluent inlet port and the effluent outlet port.

[0036] Alternatively or additionally to any of the above examples, in another example, flow of fluid into the fluid inlet port during operation of the thrombectomy catheter can be configured to move the valve element from a closed configuration to an open configuration.

[0037] Alternatively or additionally to any of the above examples, in another example, when the valve core is in the open configuration, effluent can flow freely from the thrombectomy catheter to the effluent collection bag.

[0038] In another example, a thrombectomy system may include a drive unit, a roller pump driven by the drive unit, a fluid inflow pump (the fluid inflow pump is driven by the drive unit), a thrombectomy catheter (the fluid inflow pump is configured to provide fluid inflow through the thrombectomy catheter), an effluent collection bag, an effluent waste tube extending in fluid communication between the thrombectomy catheter and the effluent collection bag (which is used to pass effluent from the thrombectomy catheter to the effluent collection bag), and a valve positioned in series with the effluent waste tube upstream of the effluent collection bag. The valve may include a valve body, an effluent inlet port, an effluent outlet port, and a fluid inlet port fluidly coupled to the fluid inlet tube, the fluid inlet port being at least substantially fluidly isolated from the effluent inlet port and the effluent outlet port. A portion of the fluid inlet tube may be disposed within the roller pump. The valve can be configured to move between a closed configuration and an open configuration, wherein the closed configuration is configured to fluidically isolate the effluent inlet port and the effluent outlet port from each other, and the open configuration is configured to fluidly connect the effluent inlet port and the effluent outlet port in response to flow of fluid through the fluid inlet tube by activating a roller pump.

[0039] Alternatively or additionally to any of the above examples, in another example, the valve may be a spool valve having a valve core movably disposed within an inner cavity of the valve, wherein the valve core is moved to an open position via pressure of the fluid in the fluid inlet pipe.

[0040] The above summary of some example embodiments is not intended to describe each disclosed embodiment or every implementation of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] The present invention may be more fully understood by considering the following detailed description of various embodiments in conjunction with the accompanying drawings, in which:

[0042] Figure 1 is a stereoscopic view of an illustrative thrombectomy system;

[0043] Figure 2 is used for Figure 1 A partially exploded perspective view of a pump, a bubble trap, a connection manifold assembly, and an associated fixing device of a pump / catheter assembly in a thrombectomy system;

[0044] Figure 3 is used for Figure 1 A partially exploded side view of a pump, a bubble trap, a connection manifold assembly, and an associated fixation device of a pump / catheter assembly in a thrombectomy system;

[0045] Figure 4 Shows relative to Figure 1 components of a thrombectomy catheter assembly and associated components of a console of a thrombectomy system;

[0046] Figure 5 Shown for Figure 1 Schematic thrombectomy catheter assembly in a thrombectomy system;

[0047] Figure 6 is a perspective view of an illustrative slide valve for use with an illustrative thrombectomy catheter assembly;

[0048] Figure 7 It is in the first form Figure 6 A cross-sectional view of an illustrative spool valve;

[0049] Figure 8 It is in the second form Figure 6 A cross-sectional view of an illustrative spool valve;

[0050] Fig. 9 is in the first form with additional features Figure 6 A cross-sectional view of an illustrative spool valve;

[0051] Fig.10is a cross-sectional view of an alternative valve core for use with a spool valve;

[0052] Fig.11 is a cross-sectional view of another illustrative valve core for use with a spool valve;

[0053] Fig.12 is a cross-sectional view of an illustrative fluid inlet tube positioned in a roller pump;

[0054] Fig.13 is a cross-sectional view of another illustrative fluid inlet tube positioned in a roller pump;

[0055] Fig.14 is a perspective view of another illustrative slide valve for use with an illustrative thrombectomy catheter assembly;

[0056] Fig.15 It is in the first form Fig.14 A cross-sectional view of an illustrative spool valve;

[0057] Fig.16 It is in the second form Fig.14 A cross-sectional view of an illustrative spool valve;

[0058] Fig.17 is a perspective view of another illustrative slide valve for use with an illustrative thrombectomy catheter assembly;

[0059] Fig.18 It is in the first form Fig.17 A cross-sectional view of an illustrative spool valve;

[0060] Fig.19 It is in the second form Fig.17 A cross-sectional view of an illustrative spool valve;

[0061] Fig. 20 is a perspective view of another illustrative slide valve for use with an illustrative thrombectomy catheter assembly;

[0062] Fig.21 It is in the first form Fig. 20 A cross-sectional view of an illustrative spool valve;

[0063] Fig. 22 It is in the second form Fig. 20 A cross-sectional view of an illustrative spool valve;

[0064] Fig.23 is a perspective view of another illustrative slide valve for use with an illustrative thrombectomy catheter assembly;

[0065] Fig.24 It is in the first form Fig.23A cross-sectional view of an illustrative spool valve; and

[0066] Fig.25 It is in the second form Fig.23 A cross-sectional view of an illustrative spool valve.

[0067] Although the present invention is suitable for various modifications and alternative forms, its specific details have been shown in the drawings by way of example and will be described in more detail. However, it should be understood that the present invention is not intended to limit the various aspects of the present invention to the specific embodiments described. On the contrary, it is intended to cover all modifications, equivalents and substitutes that fall within the spirit and scope of the present invention. DETAILED DESCRIPTION

[0068] All numerical values ​​herein are assumed to be subject to the term "about", whether or not expressly stated otherwise. The term "about" generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited number (e.g., having the same function or result). In many cases, the term "about" can indicate that the number is rounded to the nearest significant figure.

[0069] The recitation of numerical ranges by endpoints includes all numbers within that range (eg, 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).

[0070] Although some suitable sizes, ranges and / or values ​​are disclosed for various components, properties and / or specifications, those skilled in the art to which the present invention relates will understand that the desired sizes, ranges and / or values ​​may be derived from those explicitly disclosed.

[0071] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term "or" is generally employed in its sense including "and / or" unless the content clearly dictates otherwise.

[0072] The following detailed description should be read with reference to the accompanying drawings, in which similar elements in different drawings have the same numbering. The specific embodiments and the drawings, which are not necessarily drawn to scale, depict illustrative embodiments and are not intended to limit the scope of the invention. The illustrative embodiments depicted are exemplary only. Unless expressly stated to the contrary, selected features of any illustrative embodiment may be incorporated into additional embodiments.

[0073] Thrombectomy catheters and systems can be used to remove thrombi, plaques, lesions, clots, etc. from veins or arteries. In some thrombectomy systems, a roller pump can be used to balance the flow of fluid in the system. For example, a roller pump can be used to control the flow of effluent from a patient through the system, while an inflow pump provides the flow of fluid into the patient. However, in some cases, the roller pump may not run fast enough to provide the necessary fluid balance between fluid inflow and fluid outflow (e.g., effluent). A valve assembly is disclosed herein that allows the flow of effluent when the thrombectomy catheter is running (e.g., when the inflow pump is running to provide fluid inflow into the patient) and blocks the flow of effluent when the thrombectomy catheter is not running (e.g., when the inflow pump is not running, so that there is no fluid inflow into the patient). In addition, the disclosed valve assembly can operate without the need for a control signal or programming additions / changes to the thrombectomy system. For example, the disclosed valve assembly can operate without the need to send an electrical control signal to the valve assembly and / or electrically operate the valve assembly.

[0074] Figure 11 is a perspective view of an illustrative thrombectomy system 10. The thrombectomy system 10 may include a console or drive unit 12 and a pump / catheter assembly 14. In some cases, the pump / catheter assembly 14 may be a single-use device, wherein a new pump / catheter assembly 14 may be used with the drive unit 12 for each medical procedure. A plurality of removable panels 16a-16n are shown around and along the drive unit 12 on the drive unit 12, which 16 surround the internal structure of the drive unit 12. An illustrative drive unit 12 is described in the commonly assigned U.S. Patent No. 7,935,077 entitled Thrombectomy Catheter Deployment System, the disclosure of which is incorporated herein by reference. Doors 18 and 20 that can be opened automatically are located in the center of the drive unit 12 and are aligned with the lower area of ​​the panel 16g, and the doors 18 and 20 open to expose the interior of the drive unit 12 to provide access to the cradle assembly 22. As further discussed herein, the cradle assembly 22 that can accommodate components of the pump / catheter assembly 14 is shown as accessible via the doors 18 and 20 that are opened and closed. The drive unit 12 may include a sump for collecting fluid leakage from components of the pump / conduit assembly 14. For example, a removable drip tray 24 is shown as being located at the front of the drive unit 12, extending from below the bracket assembly 22 toward the panel 16a. Other configurations of the sump are also contemplated. The drip tray 24 and the removable container 26 may jointly support and contain an effluent collection bag, such as an effluent collection bag 28 of the pump / conduit assembly 14. In other cases, the drive unit 12 may include different structures, such as a hook for hanging the effluent collection bag 28 from it, or a shelf for placing the effluent collection bag 28 on it. In the case where the bracket assembly 22 is removable, the drive unit 12 may be provided with a bracket assembly activation switch 30, such as located on the panel 16g, to selectively position the bracket assembly 22 inwardly or outwardly. The drive unit 12 may be provided with a user interface 32 including a storage function, such as located at an upper region of the drive unit 12 between the upper regions of the upper side panels 16e and 16f. Saline bag hooks 34 and 36 may extend through panels 16e and 16f to hang saline bags therefrom. Drive unit 12 may include a handle 42 and a plurality of wheels 52a-52n and a brake pedal 54 for wheel locking to assist medical personnel in maneuvering drive unit 12.

[0075] The pump / catheter assembly 14, which may be a disposable, single-use device, is shown unattached to the drive unit 12. The pump / catheter assembly 14 includes a pump 56 and a thrombectomy catheter 58. During use, a portion of the pump / catheter assembly 14 may be secured within a portion of the drive unit 12. Other components included in the pump / catheter assembly 14 may include a bubble trap 60 attached to the pump 56, a connection manifold assembly 62 connected to the bubble trap 60, an effluent return tube 66 connected between the connection manifold assembly 62 and the thrombectomy catheter 58, a high pressure fluid supply tube 64 attached between the output of the pump 56 and the thrombectomy catheter 58 (which may be coaxially disposed inside the effluent return tube 66), a transition fixture 69 located between the distal end of the effluent return tube 66 and the proximal end of the thrombectomy catheter 58, an effluent waste tube 68 connecting the effluent collection bag 28 to the connection manifold assembly 62, and a fluid supply tube 70 having a bag puncture tube 71 connecting a fluid supply bag 72 (e.g., a saline bag) to the connection manifold assembly 62. The fluid supply tube 70 may be in fluid communication with the interior of the bubble trap 60 to provide fluid from the fluid supply bag 72 to the pump 56 and subsequently to the thrombectomy catheter 58 through the high pressure fluid supply tube 64.

[0076] Figure 2 1 is a partially exploded perspective view of several components of the pump / conduit assembly 14, which generally includes the pump 56, the bubble trap 60, the connecting manifold assembly 62, and the fixture 140. The pump 56 is centered on the tubular body 112. The components are located around the lower region of the tubular body 112 and include a base 109, which has an upper portion 110 and a lower portion 111, both of which are positioned around the lower region of the tubular body 112. An annular surface 117 is included at the top of the upper portion 110 of the base 109, which is used to closely contact the capture lugs of the bracket assembly 22 to contain the pump 56 within the bracket assembly 22. The top body 114 is positioned around the upper region of the tubular body 112. The base 109 and the top body 114 and the connecting panel 115 can be molded or otherwise appropriately constructed to, for example, surround a larger portion of the tubular body 112. The top body 114 may also include a data plate 113 for including a bar code, RFID tag, or other information display to determine the operating parameters of the device.

[0077] Pump 56 may include a hemispherical pump piston head 116 with a flexible cover 118 connected to and extending between top body 14 and pump piston head 116. In some cases, lower portion 111 of the geometric configuration of base 109 may serve as a mount for one end of bubble trap 60.

[0078] The connection manifold assembly 62 can be secured directly to the other end of the bubble trap 60, and in some cases can include a bracket 120 to which is attached a vertically oriented tubular manifold 148 having a plurality of ports attached or formed therethrough, including a fluid (e.g., saline) inlet port 122, an effluent outlet port 124, a Luer-style effluent return port 126, and / or an auxiliary port 128, and a cap 130. Also shown are connectors 132 and 134, which extend connectively between the connection manifold assembly 62 and the upper portion 110 of the base 109.

[0079] The bubble trap 60 may include two mating halves, one of which, 60a, is shown. A hydrophobic filter 136 may be included at an upper forward region of the bubble trap half 60a. Another hydrophobic filter may be included on a second bubble trap half (not explicitly shown) opposite the hydrophobic filter 136 on the bubble trap half 60a.

[0080] The fixture 140 and its associated components assist in supporting and connecting the effluent return tube 66 to the effluent return port 126 through the connector 142 in continuous combination with the connecting tube 144, and also assist in supporting, passing and connecting the fluid supply tube 70 to the fluid inlet port 122. The fixture 140 may include outwardly extending vertically aligned and opposed lugs 141a and 141b that prevent the fixture 140 and the associated effluent return tube 66 including the high pressure fluid supply tube 64 and the fluid supply tube 70 from contacting a roller pump (not explicitly shown) provided by the drive unit 12, such as located in or adjacent to the bracket assembly 22.

[0081] Figure 3 yes Figure 2 1 is a partially exploded side view of the elements of the pump 56, which shows the relationship of the pump 56, the bubble trap 60, the connecting manifold assembly 62 and the fixture 140. A vertically oriented tubular manifold 148 fixed to the bracket 120 is also shown. The effluent outlet port 124 can be connected to the lower interior of the tubular manifold 148 and is in fluid communication with it. The effluent return port 126 can be connected to the upper interior of the tubular manifold 148 and is in fluid communication with it. The horizontally aligned pass port 150 and the associated connector 132 (each of which is opposite the effluent return port 126) are also connected to the tubular manifold 148. The access port 150 can accommodate a high pressure fluid supply tube 64 that extends distally through a lumen (not explicitly shown) of the access port 150, the connector 132, an upper region of the tubular manifold 148, the effluent return port 126, the connector 142, the connecting tube 144, and into and through the effluent return tube 66 in a coaxial manner to connect to the thrombectomy catheter 58 ( Figure 1). The proximal end of the high pressure fluid supply tube 64 includes a high pressure fitting 152 located near the proximal end of the high pressure fluid supply tube 64 to facilitate connecting the high pressure fluid supply tube 64 with the interior of the pump 56 in a fluid communication manner. The proximal end of the high pressure fluid supply tube 64 (which is the entrance to the high pressure fluid supply tube 64) may include a plurality of very small perforations (not shown) including a filter at its proximal end. A connector 134, which may have internal and / or external threads, may be aligned above and around the high pressure fluid supply tube 64 located distal to the high pressure fitting 152 and threadedly engage a threaded connection port 154 extending horizontally from the upper portion of the base 109 of the pump 56. The connector 134 may be rotated to threadably engage the high pressure fitting 152 with a corresponding mating threaded structure provided with the pump 56. The connector 132 may be used to engage the externally threaded end of the connector 134 to secure the connector 134 and thereby the pump 56 to the connection manifold assembly 62, as well as to provide for the securement of the bubble trap 60 to the pump 56. Additionally, a direct connection and fluid communication between the pump 56 and the bubble trap 60 may be provided by a horizontally oriented pump fluid inlet port 156 that joins the interior of a corresponding receiver port 158 ​​and seal 159 to one end of the bubble trap 60. A fluid inlet port 122 located on the bracket 120 may extend behind the tubular manifold 148 to communicate with the interior of the bubble trap 60 to enable debubbling of a fluid (e.g., saline) whereby unpressurized fluid (e.g., saline) may be made available to the pump 56.

[0082] Figure 4 3 is a perspective view of an illustrative disposable pump / catheter assembly 14 with a cradle assembly 22 of a drive unit 12 of a thrombectomy system 10. Generally, operation of the thrombectomy system 10 may utilize a user interface 32 to control its functional operation along with other components. The thrombectomy system 10 may be initiated by opening a sterile package containing a disposable pump / catheter assembly 14 for loading into the drive unit 12. At an appropriate time, the cradle assembly 22 may be accessed (e.g., doors 18, 20 may be opened on the drive unit 12) to receive the various components of the pump / catheter assembly 14. For example, after a user initiates a procedure with the user interface 32, the doors 18, 20 may open automatically.

[0083] In some cases, the pump 56 can be aligned to the receiver slot 335 of the capture block 222 of the carriage assembly 22, and the base 109 of the pump 56 is then pushed to engage the receiver slot 335 of the capture block 222. In embodiments where the carriage assembly 22 is movable, a carriage motor (not explicitly shown) can then be energized, such as by pressing an activation switch 30 of the carriage assembly or selecting an input on the user interface 32, to movably actuate the carriage assembly to a closed position in which the pump piston head 116 is in contact with the reciprocating linear actuator 84 ( Figure 4 288 (shown in FIG. 29 ). When the slots 330 and 332 of the capture block 222 engage the capture lugs 290, 292 of the capture clip 288 (at which point the capture lugs 290, 292 simultaneously engage the annular surface 117 of the pump 56), the pump 56 may be captured in the receiver slot 335 of the capture block 222 during the inward advancement of the capture block 222. The capture pump 56 provides a secure and stable mounting and support for the pump 56 and components directly associated with the pump 56, such as, but not limited to, the bubble trap 60, the proximal end of the connection manifold assembly 62 and the effluent waste tube 68, the saline supply tube 70, the effluent return tube 66, and other associated structures. In other embodiments where the bracket assembly 22 is stationary, the pump piston head 116 can be aligned with the reciprocating linear actuator 84 when the base 109 of the pump 56 is engaged into the receiver slot 335. The reciprocating linear actuator 84 may then be actuated to engage and capture the pump piston head 116, such that the reciprocating up and down strokes of the reciprocating linear actuator 84 drive the pump 56. Thereafter, the doors 18, 20 may be closed. For example, a fluid supply bag 72, which may contain heparinized saline, may be pierced and appropriately positioned, such as on a saline bag hook 34 or 36, before or after loading the pump 56.

[0084] An effluent waste tube 68 may also be positioned on the roller pump 240 between the tube guides 212 and 214, with the effluent collection bag 28 connected to the effluent waste tube 68. The effluent collection bag 28 may be appropriately positioned to collect effluent during the medical procedure. The pump rollers (not shown) of the roller pump 240 may rotatably engage the effluent waste tube 68 to control the flow of effluent fluid through the effluent waste tube 68 to the effluent collection bag 28.

[0085] When appropriate, the thrombectomy catheter 58 may undergo a priming procedure to clear any air from the thrombectomy catheter 58. For example, the tip of the thrombectomy catheter 58 may be placed in a bowl of sterile saline or other fluid, and the pump 56 may be operated by the action of the reciprocating linear actuator 84 to prime the thrombectomy catheter 58. Thereafter, the medical staff may insert the thrombectomy catheter 58 into the patient's vascular system at a convenient time, and may begin operating the thrombectomy system 10 including the user interface 32 and the foot switch (not explicitly shown) as needed. The reciprocating linear actuator 84 is actuated according to the operating parameters to affect the appropriate fluid inflow pressure, pump speed, flow rate, etc. to operate the pump 56 to deliver pressurized fluid to the thrombectomy catheter 58 via the high pressure fluid supply tube 64 residing in the effluent return tube 66. As previously described, the supplied fluid is routed through the bubble trap 60 and brought to high pressure by the pump 56, and reaches the thrombectomy catheter 58 through the high pressure fluid supply tube 64 for use in thrombectomy or other related procedures. The effluent returns to the connection manifold assembly 62 via the effluent return tube 66 for collection in the effluent collection bag 28 via the effluent waste tube 68 , which may be controlled by the roller pump 240 .

[0086] During some medical procedures, the flow of effluent through the effluent waste tube 68 may be controlled by the roller pump 240. For example, when the roller pump is actuated (e.g., rotated), effluent may be diverted from the patient through the lumen of the effluent return tube 66 via the effluent waste tube 68 to the effluent collection bag 28. The speed of the roller pump 240 may be controlled to balance the fluid flow within the pump / catheter assembly 14 (e.g., to balance the inflow of fluid into the patient through the fluid inflow path through the vascular resection catheter 58 and the outflow of fluid from the patient to the effluent collection bag 28 through the fluid outflow path through the vascular resection catheter 58 and the effluent waste tube 68).

[0087] However, in some cases, the roller pump 240 may not be able to run fast enough to achieve fluid balance (e.g., the effluent outflow flow rate achievable by the roller pump 240 may be significantly less than the fluid inflow generated by the pump, such that the desired fluid balance between the fluid inflow and the effluent outflow cannot be achieved. In such cases, an alternative configuration of the outflow path may be provided, as described herein. Figure 54 is a schematic side view of a pump / catheter assembly 14, which also includes a valve 400, such as a spool valve, to control fluid balance in the system in the event that a higher fluid flow rate is required during a thrombectomy procedure. Although the valve 400 is described herein as a spool valve, it is contemplated that the valve 400 may have a different configuration if desired. As will be described in more detail herein, the spool valve 400 is positioned in series with the effluent waste tube 68 and is configured to allow flow of effluent through the valve 400 when the pump / catheter assembly 14 is in use (e.g., when the pump 56 is activated and operated to provide fluid inflow through the thrombectomy catheter 58) and to prevent flow of effluent through the valve 400 to the waste bag 28 when the pump / catheter assembly 14 is not in use (i.e., when the pump 56 is deactivated and not operating). A fluid inlet tube 490 may be fluidly coupled to a first end 402 of the spool valve 400. The fluid inlet tube 490 may extend from a first end 492 coupled to the spool valve 400 to a second end 493. In some cases, the second end 493 of the fluid inlet tube 490 can be open to ambient air, or the second end 493 of the fluid inlet tube 490 can be fluidically coupled to a fluid source. In some embodiments, the fluid source can be a liquid (e.g., saline) supply bag. In some cases, the liquid bag can be the same fluid supply bag 72 that supplies saline or other fluids to the thrombectomy catheter 58. For example, a Y-connector can be used to allow fluid (e.g., saline) to flow from the fluid supply bag 72 to both the thrombectomy catheter 58 and the slide valve 400. In other examples, the second end 493 of the fluid inlet tube 490 can be connected to a fluid source (e.g., fluid supply bag 72) via a bubble trap 60. In other embodiments, the fluid inlet tube 490 can be fluidically coupled to a separate fluid supply bag. In further embodiments, the fluid inlet tube 490 can be fluidically coupled to different fluid sources, such as, but not limited to, water, ambient air, etc. The middle portion 494 of the fluid inlet tube 490 may be positioned in the roller pump 240 in place of the effluent waste tube 68 to supply fluid to the spool valve 400, as will be described in greater detail herein. Thus, during a medical procedure in which the spool valve 400 is used with the pump / catheter assembly 14, the effluent waste tube 68 may not be positioned in the roller pump 240, but rather the effluent waste tube 68 may be branched from the effluent return tube 66 using, for example, a T-connector or other suitable flow diversion mechanism, and the fluid inlet tube 490 to the spool valve 400 may be placed in the roller pump 240 such that the outflow from the roller pump 240 passes through the fluid inlet tube to the spool valve 400 to actuate the spool valve 400 to the open position.The spool valve 400 can be placed in the fluid path of the effluent waste tube 68 upstream of the effluent waste bag 28, such that when the spool valve 400 is in the open position, effluent passes through the spool valve 400 to the effluent waste bag 28, thereby providing for the outflow of effluent from the thrombectomy catheter 58, and when the spool valve 400 is in the closed position, effluent is prevented from passing through the spool valve 400 to the effluent waste bag 28, thereby preventing the outflow of effluent from the thrombectomy catheter 58. Thus, when the roller pump 240 is running, the spool valve 400 can be actuated to the open position, and when the roller pump 240 is not running, the spool valve 400 can be actuated to the closed position. The activation of the roller pump 240 can be tied to the activation of the pump 56, such that when the pump 56 is running or activated (e.g., via a user input to the drive unit 12), the roller pump 240 is automatically started or activated (e.g., via a control signal from the drive unit 12). Likewise, when pump 56 is turned off or disabled (eg, via user input to drive unit 12 ), roller pump 240 is automatically turned off or disabled (eg, via a control signal from drive unit 12 ).

[0088] Figure 6 4 is a perspective view of an illustrative spool valve 400. The spool valve 400 may include a valve body 410, which in some cases may have a generally tubular cylindrical structure extending from a first end 402 to a second end 404. A fluid inlet port 406 may extend from the first end 402. The fluid inlet port 406 may be configured to be fluidically coupled to a fluid inlet tube 490. For example, the fluid inlet port 406 may be configured such that the fluid inlet tube 490 may be disposed above and around the fluid inlet port 406, or may be configured such that the fluid inlet tube 490 extends within the fluid inlet port 406 as desired. In other cases, the fluid inlet tube 490 may be threadedly coupled to the fluid inlet port 406. The fluid inlet port 406 may be removably coupled to the valve body 410 using, for example, a removable threaded fitting 414a. Other coupling means may be used as desired, such as, but not limited to, press fit, snap fit, friction fit, snap ring, etc. In some embodiments, the fluid inlet port 406 can include a tube barb that includes one or more raised ridges 416a. The diameter of the raised ridges 416a can increase toward the valve body 410. This can facilitate assembly of the fluid inlet tube 490 with the fluid inlet port 406 while preventing accidental removal of the fluid inlet tube 490 from the fluid inlet port 406.

[0089] The effluent inlet port 408 and the effluent outlet port 412 can extend from the valve body 410, such as extending from the curved sidewall of the valve body 410. Each of the effluent inlet port 408 and the effluent outlet port 412 can be configured to be fluidly coupled to certain portions of the effluent waste pipe 68. A first portion of the effluent waste pipe 68 can be fluidly coupled to the effluent inlet port 408 (e.g., disposed above or within the effluent inlet port 408) and extend therefrom as desired. A second portion of the effluent waste pipe 68 can be fluidly coupled to the effluent outlet port 412 (e.g., disposed above or within the effluent outlet port 412) and extend therefrom as desired. The effluent inlet port 408 and the effluent outlet port 412 can be fluidly isolated from the fluid inlet port 406. In some cases, the effluent inlet port 408 and the effluent outlet port 412 can be substantially fluidly isolated from the fluid inlet port 406. For example, when the effluent inlet port 408 and the effluent outlet port 412 are substantially fluidically isolated from the fluid inlet port 406, a small pressure relief fluid path may extend from the fluid inlet port 406 through the sliding valve 400 to the effluent inlet port 408 and / or the effluent outlet port 412, which allows pressure in the fluid inlet pipe 490 to be released from the sliding valve 400 to close the sliding valve 400, as will be described in more detail herein.

[0090] In some cases, the effluent inlet port 408 and the effluent outlet port 412 can be positioned on opposite sides of the valve body 410, such as about 180 ° apart from each other. For example, the effluent inlet port 408 and the effluent outlet port 412 can be positioned along a common axis and extend from opposite sides of the valve body 410 along the common axis. Other positions and / or configurations of the effluent inlet port 408 and the effluent outlet port 412 can be used as needed. Each of the effluent inlet port 408 and the effluent outlet port 412 can be removably connected to the valve body using, for example, removable threaded nuts 414b, 414c. Other coupling methods can be used as needed, such as, but not limited to, press fit, snap fit, friction fit, snap rings, etc. One or both of the effluent inlet port 408 and the effluent outlet port 412 can include raised ridges 416b, 416c. The diameter of the raised ridges 416b, 416c can increase toward the valve body 410. This can facilitate assembly of the effluent waste tube 68 with the effluent inlet port 408 and / or the effluent outlet port 412 while preventing accidental removal of the effluent waste tube 68 from the effluent inlet port 408 and / or the effluent outlet port 412. As described above, the slide valve 400 can be positioned in series with the effluent waste tube 68. For example, the effluent inlet port 408 can be positioned downstream of the connection manifold assembly 62, and the effluent outlet port 412 can be positioned upstream of the effluent collection bag 28. For example, effluent can flow from the thrombectomy catheter 58 through the effluent return tube 66, through the connection manifold assembly 62, and into the effluent waste tube 68. Once in the effluent waste tube 68, the effluent can pass through the slide valve 400 before entering the effluent collection bag 28.

[0091] The slide valve 400 may also include a pressure relief valve or port 418. Typically, the pressure relief valve or port 418 may be actuated to exhaust air from the slide valve 400 prior to use. The pressure relief valve or port 418 may include an actuation element 420, such as, but not limited to, a nut. Figure 7, which is a cross-sectional view of the sliding valve 400 in a first or closed configuration, the actuating element 420 can be releasably coupled to a threaded region 426 of a screw or post 422. The post 422 can extend from a head 428 positioned within the valve body 410 to a second end 430 outside the valve body 410. The threaded region 426 can extend through an opening or hole 432 extending through a sidewall of the valve body 410. The head 428 can have a larger diameter or cross-sectional dimension than the hole 432 to prevent the post 422 from being disengaged from the valve body 410. An O-ring 434 or other sealing member can be positioned between the head 428 and the inner surface of the sidewall of the valve body 410 to fluidly seal the hole 432. A spring 424 or other biasing mechanism can be positioned between the actuating element 420 and the outer surface of the valve body 410. The spring 424 can be positioned around the threaded region 426 of the post 422 and is configured to bias the drive element 420 away from the outer surface of the valve body 410 in the absence of an external force. The actuating element 420 can be pressed toward the valve body 410 to compress the spring 424 and move the O-ring 434 and the head 428 away from the inner surface of the side wall of the valve body 410 to allow air to vent from the interior of the valve body 410 through the hole 432. When the force is removed from the actuating element 420, the spring 424 biases the actuating element 420 away from the outer surface of the valve body 410 wall and moves the O-ring 434 and the head 428 into engagement with the hole 432 and the inner surface of the valve body 410 wall to fluidly seal the hole 432.

[0092] Still reference Figure 7 And also refer to Figure 8, which is a cross-sectional view of the spool valve 400 in a second or open configuration, the effluent inlet port 408 can define a cavity 436 extending from a first end 438 exterior to the valve body 410 to a second end 440 disposed interior to the valve body 410. The effluent inlet port 408 can extend into a through hole 442 extending through a sidewall of the valve body 410. The through hole 442 can extend through the thickness of the valve body 410 in a direction generally orthogonal to a longitudinal axis 454 of the spool valve 400 to define an opening from the exterior of the valve body 410 to an interior chamber or cavity 460 of the valve body 410. Similarly, the effluent outlet port 412 can define a cavity 444 extending from a first end 446 exterior to the valve body 410 to a second end 448 disposed interior to the valve body 410. The effluent outlet port 412 can extend into a through hole 450 extending through a sidewall of the valve body 410. The through hole 450 can extend through the thickness of the valve body 410 in a direction generally orthogonal to the longitudinal axis 454 of the spool valve 400 to define an opening from the exterior of the valve body 410 to the interior cavity 460 of the valve body 410. The through holes 442, 450 can be in selective fluid communication with the interior cavity 460 and with each other. In other cases, the effluent inlet port 408 and / or the effluent outlet port 412 can be integrally formed with the valve body 410, such that the valve body 410 is a unitary structure including the effluent inlet port 408 and / or the effluent outlet port 412.

[0093] A generally cylindrical valve core or piston 452 may be slidably disposed within the interior cavity 460 of the valve body 410. The valve core 452 may be actuated along or in-line with the longitudinal axis 454 of the spool valve 400. In the first or closed configuration ( Figure 7 ), the valve core 452 can be positioned to block or close the through holes 442, 450 and thus block or close the cavities 436, 444 of the effluent inlet port 408 and the effluent outlet port 412. In the second or open configuration ( Figure 8 ), the valve core 452 can be displaced along the longitudinal axis 454 to align the fluid path through or around the valve core 452 to fluidly connect the cavity 436 of the effluent inlet port 408 with the cavity 444 of the effluent outlet port 412. For example, the valve core 452 can include an annulus or annular groove 456 formed around the circumference of the outer surface of the valve core 452, which can be moved to align with the through holes 442, 450 in the second or open configuration. This can fluidly connect the cavity 436 of the effluent inlet port 408 with the cavity 444 of the effluent outlet port 412. It should be noted that in the first or closed configuration, the annular groove 456 of the valve core 452 can be moved to a position that is offset from the through holes 442, 450 to fluidly isolate the effluent inlet port 408 from the effluent outlet port 412.

[0094] The diameter of the spool 452 can vary over its length. The middle portion 486 of the spool 452 can have an outer diameter that is substantially the same as the inner diameter of the inner cavity 460 so as to form a fluid-tight seal at the through-holes 442, 450 when the spool 452 is in the closed configuration. In some embodiments, the spool 452 can be formed of an elastic material, such as but not limited to rubber, silicone, etc., to allow a portion of the spool 452 to contact the inner surface of the valve body 410 and create a fluid-tight seal. Although not explicitly shown, in some cases, a sealing material, such as but not limited to an O-ring, a gasket, or other seal, etc., can be disposed along the outer surface of the spool 452 or at its ends to provide a fluid-tight seal between the spool 452 and the valve body 410. It is contemplated that the middle portion 486 of the spool 452 can fluidly isolate the first end region 476 of the spool 452 from the second end region 478 of the spool 452.

[0095] A spring 470 or other biasing mechanism may be disposed within the interior cavity 460 of the valve body 410, such as opposite the fluid inlet port 406. The spring 470 may extend from a first end 472 configured to be positioned adjacent to and / or in contact with a second end portion 478 of the valve core 452 to a second end 474 configured to be positioned adjacent to and / or in contact with a second end piece 480 of the spool valve 400. In the absence of an external force, the spring 470 may be configured to bias the valve core 452 toward the first or closed configuration.

[0096] The valve core 452 can be actuated to Figure 8 4 and 5. In the open configuration shown, the fluid flows through the fluid inlet port 406. For example, the fluid inlet port 406 can define a cavity 458 extending from a first end 462 outside of a first end piece 466 of the spool valve 400 to a second end 464 disposed inside the first end piece 466. The fluid inlet port 406 can extend into a through hole 468 extending through the first end piece 466 along or in line with the longitudinal axis 454 of the spool valve 400. The through holes 442, 468 can be in fluid communication with the inner cavity 460 of the valve body 410. The fluid can flow through the fluid inlet tube 490 and into the through hole 468 of the first end piece 466 in the inner cavity 460. Once sufficient fluid pressure builds up within the inner cavity 460 against the first end region 475 of the valve core 452, the fluid can push the valve core 452 toward the second end 404 of the spool valve 400 and compress the spring 470 to move the valve core 452 from the first closed configuration (closed configuration). Figure 7 ) moves to the second opening pattern ( Figure 8). For example, sufficient fluid pressure can be the amount of pressure required to overcome the biasing force of spring 470. When valve core 452 is actuated toward second end 404, second end region 478 of valve core 452 can contact first end 484 of second end piece 480 to provide a mechanical stop that is spaced to align annular groove 456 with through-holes 442, 450 (and therefore with chambers 436, 444). In some cases, through-hole 482 can extend through second end piece 480 to allow air to escape from interior chamber 460 when valve core 452 moves toward second end 404 of spool valve 400. In addition, through-hole 482 can allow air to enter interior chamber 460 when valve core 452 moves toward first end 402 of spool valve 400.

[0097] The first and / or second end pieces 466, 480 can be provided as separate components that are assembled with the valve body 410. The first and / or second end pieces 466, 480 can be secured to the valve body 410 using any desired means, such as, but not limited to, adhesives, friction fits, mechanical engagement, welding, soldering, brazing, threaded engagement, etc. In other embodiments, at least one of the first and second end pieces 466, 480 can be formed as a single unitary structure with the valve body 410. It is contemplated that the first and / or second end pieces 466, 480 can each include a first portion configured to be received within the inner cavity 460 and a second portion configured to have an outer diameter similar to the valve body 410.

[0098] The sliding valve 400 can be configured to open (e.g., actuate the valve core 452) substantially synchronously when the thrombectomy catheter 58 is used. For example, when the clinician activates the drive unit 12 (e.g., operates a foot switch (not explicitly shown) on the drive unit 12), both the pump 56 and the roller pump 240 are activated. In some cases, when the clinician activates the drive unit 12, the pump 56 can be automatically activated simultaneously or successively with the roller pump 240. Because a portion 494 of the fluid inlet tube 490 is disposed within the roller pump 240, actuation of the roller pump 240 drives the fluid through the fluid inlet tube 490 and into the inner cavity 460 of the valve body 410 via the fluid inlet port 406. As described above, the fluid can be saline, ambient air, or other fluid. The fluid pushes the valve core 452 to an open configuration ( Figure 8) and allows free flow of effluent through the effluent waste tube 68, along the flow path from the effluent inlet port 408 to the effluent outlet port 412, through the slide valve 400, and into the effluent collection bag 28. For example, the flow of effluent is not limited by the speed of the roller pump 240. Instead, the effluent can flow freely at a rate that achieves fluid flow balance within the system. Since there is no fluid outlet near the first end 476 of the valve core 452, fluid flow may cause the roller pump 240 to stop, and no additional fluid will be delivered to the inner cavity 460 of the slide valve 400, thereby maintaining the valve core 452 in the open position. When the clinician deactivates the drive unit 12 (e.g., releases the foot switch) to stop the operation of the thrombectomy catheter 58, the pump 56 and the roller pump 240 are deactivated, thereby stopping the inflow of fluid to the thrombectomy catheter 58. Since roller pump 240 is not a perfect pump, pressure may dissipate from lumen 460 and spring 470 may again bias valve element 452 toward first end 402 and the closed configuration to stop the flow of effluent through valve 400 to effluent waste bag 28 .

[0099] It is contemplated that other means may be provided to release pressure against the spool 452 to allow the spool 452 to return to the closed position via the spring 470 when the drive unit 12 (including the pump 45 and the roller pump 240) is deactivated. For example, the spool valve 400 may be provided with additional features to facilitate the release of pressure against the spool 452 once the roller pump 240 is stopped. In some embodiments, the spool valve 400 may include a small fluid path (i.e., a leak path) that fluidly connects the inner cavity 460 with the effluent path (e.g., the cavity 444 of the effluent outlet port 412 and / or the cavity 436 of the effluent inlet port 408). The small fluid path may be sized so that a pressure differential against the spool 452 may be maintained to actuate the spool 452 to the open position when the roller pump 240 is in operation, and when the roller pump 240 is stopped, the fluid in the cavity 460 is discharged to release pressure and thereby close the valve 400 (i.e., allowing the spool 452 to move to the closed position). Fig. 94 is a cross-sectional view of a spool valve 400 in a first closed configuration and including a small fluid path, which is shown as a longitudinally extending small leakage channel, such as a groove or recess 496, formed within the outer surface of the valve core 452. The groove 496 can extend from the first end region 476 of the valve core 452 toward the second end region 478 to a position on the second end side of the annular groove 456 to create a leakage path aligned with one or both of the through holes 442, 450 to further relieve pressure when the roller pump 240 is stopped or otherwise no longer active (i.e., not rotating). The small leakage channel 496 forming the leakage path can have a sufficient length to extend from the cavity 460 to the effluent path (e.g., the cavity 444 of the effluent outlet port 412 and / or the cavity 436 of the effluent inlet port 408) when the valve core 452 is in both the open and closed positions. Other configurations of the leakage path are also contemplated. For example, with reference to Fig.10 , which is a cross-sectional view of an illustrative valve core 452, the leakage path can be a small leakage channel 457 that extends through the interior of the valve core 452 so that when the valve core 452 is in the open position, the small leakage channel extends from the cavity 460 to the effluent path (e.g., the cavity 444 of the effluent outlet port 412 and / or the cavity 436 of the effluent inlet port 408). In the illustrated embodiment, the leakage channel 457 can have a generally "L"-shaped form, wherein a first portion of the leakage channel 457 can extend axially from the first end region 476 along the central axis of the valve core 452, and a second portion can extend perpendicularly thereto (and therefore perpendicularly to the central axis of the valve core) from the first portion to the annular groove 456, thereby connecting the first end region 476 to the annular groove 456. However, this is not required. It is contemplated that the leakage channel 457 can take other shapes as desired. In the illustrative example, leakage passage 457 may be in fluid communication with the effluent path in an open position, and leakage passage 457 may be fluidly isolated from the effluent path in a closed position.

[0100] In another example, the leak path may be a small leak passage extending through the interior of the valve core 452 such that the small leak passage extends from the cavity 460 to the effluent path (e.g., the cavity 444 of the effluent outlet port 412 and / or the cavity 436 of the effluent inlet port 408) when the valve core 452 is in both the open and closed positions. In another embodiment, the leak path may be a small leak passage extending along the valve core 452 and inside the valve body 410 such that the small leak passage extends from the cavity 460 to the effluent path (e.g., the cavity 444 of the effluent outlet port 412 and / or the cavity 436 of the effluent inlet port 408) when the valve core 452 is in both the open and closed positions. In yet another embodiment, the leak path may be a small leak passage extending from the cavity 460 through the valve body 410 to the exterior of the valve body 410. It is contemplated that when a leak path is provided, the pressure relief valve or port 418 may be omitted. In yet another embodiment, the leak path may be incorporated into the pressure relief valve or port 418 .

[0101] Fig.11 4 is a cross-sectional view of a valve core 452 including an alternative small fluid path 459 formed in a fluid passage 459 and incorporating a leakage channel of a one-way valve. The fluid path 459 may include a first portion or channel 461. The first channel 461 may have a substantially constant first diameter D1 extending from the first end region 746 of the valve core 452 toward the second end region 478. The diameter D1 may transition from the first diameter to a second smaller diameter D2 at a position between the first end region 476 and the annular groove 456. The transition may be a gradual taper or may be an abrupt step-like transition as desired. The first channel 461 may be in fluid communication with a second channel 463 extending from the second end of the first channel 461 to the annular groove 456. In the illustrated embodiment, the second channel 463 may have a substantially "L" shaped configuration. However, this is not required. It is contemplated that the second channel 463 may have other shapes as desired. A one-way valve, such as a check ball 465, can be positioned within the first channel 461, and a plug 467 can be inserted into the first channel 461 adjacent to the first end of the first channel 461. The plug 467 can be configured to close the first end of the first channel 461 to retain the check ball 465 within the first channel 461. The plug 467 can include a leakage channel 469 extending through its length, which connects the cavity 460 with the first channel 461 having the check ball 465 positioned therein. Collectively, the leakage channel 469, the first channel 461, and the second channel 463 can create a leakage path that aligns with one or both of the through-holes 442, 450 to further dissipate pressure when the roller pump 240 is stopped or otherwise no longer active (i.e., not rotating).

[0102] The small fluid paths 469, 461, 463 forming the leakage path can be sized so that when the roller pump 240 is running, a pressure differential can be maintained against the valve core 452 in the chamber 460 to actuate the valve core 452 to the open position, and when the roller pump 240 is stopped, the fluid in the chamber 460 is discharged to release the pressure and thus close the valve 400 (i.e., allow the valve core 452 to move to the closed position). For example, the roller pump 240 drives the fluid through the fluid inlet tube 490 and enters the inner chamber 460 of the valve body 410 via the fluid inlet port 406. The fluid pushes the valve core 452 to the open configuration ( Figure 8 ) and allows free flow of effluent through the effluent waste tube 68, along the flow path 488 from the effluent inlet port 408 to the effluent outlet port 412, through the slide valve 400 and into the effluent collection bag 28. Some fluid can enter the first channel 461 via the leakage path 469. The pressure of the fluid in the first channel 461 can push the check ball 465 toward the opening of the second channel 463, and thus away from the leakage path 469, to allow a small amount of fluid to flow around the check ball 465, into the second channel 463 and out of the effluent path. When the roller pump 240 is deactivated, the inflow of fluid into the fluid inlet port 406 is stopped, while some fluid remains in the cavity 460. Fluid remaining in the cavity 460 can be released by passing from the cavity 460 through the leakage path 469 and through the check ball 465 into the second passage 463 within the first passage 461 to allow pressure to dissipate through the second passage 463, the annular groove 456, and one or both of the through holes 442, 450 in the effluent path. Once the fluid pressure in the cavity 460, and therefore in the first passage 461 and the leakage passage 469, drops below a threshold amount, the check ball 465 can move toward the leakage passage 469 and close the leakage passage 469, thereby preventing effluent in the effluent path from passing through the check ball 465 into the leakage passage 469 and the cavity 460. Thus, this configuration provides a one-way valve to allow fluid from the inner cavity 460 to pass through the one-way valve to the effluent path, but prevents effluent in the effluent path from passing through the one-way valve to the cavity 460. In some cases, a spring or other biasing member may be provided to bias the check ball 465 within the first passage 461.

[0103] In other cases, the leak path may be provided by a portion of the fluid inlet tube 490 that passes through the roller pump 240 . Fig.12 A first example is shown in Fig.122 is a cross-sectional view showing a portion of a fluid inlet tube 490 sandwiched between rollers 242 and housing 246 of a roller pump 240. As is generally understood, a roller pump 240 may include a rotating rotor 244 having a plurality of rollers 242 attached thereto. As the rotor 244 rotates, the rollers 242 compress the tube 490 to push a fluid mass through the lumen of the tube 490 in front of the rollers 242. Fig.12 In an embodiment of the present invention, wire 500 may be positioned in the lumen of fluid inlet tube 490 through at least the portion of fluid inlet tube 490 that passes through roller pump 240. Placing wire 500 within the lumen of tube 490 may prevent roller 242 from completely occluding the collapsed or compressed lumen of tube 490 between roller 242 and housing 246, thereby leaving a leakage passage 510 through tube 490 side-by-side with wire 500 from a location upstream of roller pump 240 to a location downstream of roller pump 240. Thus, a small leakage passage may be formed from lumen 460 of valve 400 by fluid flowing into the lumen of tube 490 and through roller pump 240, such that when roller pump 240 is deactivated or stopped, fluid in lumen 460 may pass through leakage passage 510 in tube 490 in a retrograde direction.

[0104] Alternatively, in Fig.13 In an embodiment of the present invention, a small recess 498 or a plurality of recesses 498 may be formed in the inner wall of the fluid inlet tube 490 at least along the portion of the fluid inlet tube 490 that passes through the roller pump 240. The presence of the small recess 498 may prevent the roller 242 from completely occluding the collapsed or compressed cavity of the tube 490 between the roller 242 and the housing 246, thereby leaving a leakage path 510 through the tube 490 from a location upstream of the roller pump 240 to a location downstream of the roller pump 240. Thus, a small leakage path may be formed from the cavity 460 of the valve 400 through the flow of fluid into the cavity of the tube 490 and through the roller pump 240, such that when the roller pump 240 is deactivated or stopped, the fluid in the cavity 460 may pass through the leakage path 510 in the tube 490 in a retrograde direction.

[0105] Fig.14 6 is a perspective view of another illustrative spool valve 600. Spool valve 600 may include a valve body 610, which in some cases may have a generally tubular cylindrical structure extending from a first end 602 to a second end 604. A fluid inlet port 606 may extend from first end 602. Fluid inlet port 606 may be configured to fluidically couple to fluid inlet tube 490, such as with respect to Figure 5The fluid inlet pipe 490 described. For example, the fluid inlet port 606 can be configured so that the fluid inlet pipe 490 can be disposed above and around the fluid inlet port 606, or can be configured so that the fluid inlet pipe 490 extends within the fluid inlet port 606 as needed. In other cases, the fluid inlet pipe 490 can be threadedly connected to the fluid inlet port 606. The fluid inlet port 606 can be formed as a single integral structure with the valve body 610. In other embodiments, the fluid inlet port 606 can be removably coupled to the valve body 610 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the fluid inlet port 606 can include a pipe barb including one or more raised ridges 616a. The diameter of the raised ridges 616a can increase toward the valve body 610. This can facilitate the assembly of the fluid inlet pipe 490 with the fluid inlet port 606 while preventing the fluid inlet pipe 490 from being accidentally removed from the fluid inlet port 606.

[0106] The effluent inlet port 408 may extend from the valve body 610, such as from a curved sidewall of the valve body 610. The effluent outlet port 612 may extend from the second end 604 of the valve body 610. For example, the effluent inlet port 608 and the effluent outlet port 612 may extend at angles substantially orthogonal to each other. Each of the effluent inlet port 608 and the effluent outlet port 612 may be configured to be fluidly coupled to a portion of the effluent waste pipe 68. The first portion of the effluent waste pipe 68 may be fluidly coupled to the effluent inlet port 608 (e.g., disposed above or within the effluent inlet port 608) and extend therefrom as desired. The second portion of the effluent waste pipe 68 may be fluidly coupled to the effluent outlet port 612 (e.g., disposed above or within the effluent outlet port 612) and extend therefrom as desired. The effluent inlet port 608 and the effluent outlet port 612 can be fluidly isolated from the fluid inlet port 606. In some cases, the effluent inlet port 608 and the effluent outlet port 612 can be substantially fluidly isolated from the fluid inlet port 606. For example, when the effluent inlet port 608 and the effluent outlet port 612 are substantially fluidly isolated from the fluid inlet port 606, a small pressure relief fluid path can extend from the fluid inlet port 606 through the spool valve 600 to the effluent inlet port 608 and / or the effluent outlet port 612, which allows pressure in the fluid inlet pipe 490 to be released from the spool valve 600 to close the spool valve 600, as will be described in more detail herein.

[0107] In some cases, the effluent inlet port 608 and the effluent outlet port 612 can be positioned so that their respective flow paths are approximately 90° relative to each other. Other positions and / or configurations of the effluent inlet port 608 and the effluent outlet port 612 can be used as needed. The effluent inlet port 608 can be formed as a single integral structure with the valve body 610. In other embodiments, the effluent inlet port 608 can be removably coupled to the valve body 610 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the effluent outlet port 612 can be removably coupled to the valve body 610 using, for example, a removable threaded bonnet 614. Other coupling methods such as, but not limited to, press fits, snap fits, friction fits, snap rings, etc. can be used as needed. In other examples, the effluent outlet port 612 can be formed as a single integral structure with the valve body 610. One or both of the effluent inlet port 608 and the effluent outlet port 612 may include one or more raised ridges 616b, 616c. The diameter of the raised ridges 616b, 616c may increase toward the valve body 610. This may facilitate assembly of the effluent waste tube 68 with the effluent inlet port 608 and / or the effluent outlet port 612 while preventing the effluent waste tube 68 from being accidentally removed from the effluent inlet port 608 and / or the effluent outlet port 612.

[0108] As described above, the spool valve 600 can be positioned in series with the effluent waste tube 68. For example, the effluent inlet port 608 can be positioned downstream of the connecting manifold assembly 62, and the effluent outlet port 612 can be positioned upstream of the effluent collection bag 28. For example, effluent can flow from the thrombectomy catheter 58 through the effluent return tube 66, through the connecting manifold assembly 62, and into the effluent waste tube 68. Once in the effluent waste tube 68, the effluent can pass through the spool valve 600 before entering the effluent collection bag 28. It is contemplated that positioning the effluent outlet port 612 at a non-parallel angle to the effluent inlet port 608 or in line with the fluid inlet port 606 can allow the spool valve 600 to be suspended with its longitudinal axis extending in a generally vertical direction. This, in turn, can allow the fluid inlet port 606 to be aligned with the fluid inlet tube 490. It is also contemplated that placing the effluent outlet port 612 in line with the fluid inlet port 606 may allow the waste bag 28 to be easily placed on the drip tray 24 of the console.

[0109] Additional references Fig.15 , which is a cross-sectional view of the spool valve 600 in a first or closed configuration, and reference Fig.16, which is a cross-sectional view of the spool valve 600 in a second or open configuration, the effluent inlet port 608 can define a cavity 618 extending from a first end 620 outside the valve body 610 to a second end 622 disposed inside the valve body 610. The cavity 618 of the effluent inlet port 608 can extend through the sidewall of the valve body 610 in a direction generally orthogonal to the longitudinal axis 624 of the spool valve 600 to define an opening from the exterior of the valve body 610 to an interior chamber or cavity 626 of the valve body 610. The cavity 618 of the effluent inlet port 608 can be in selective fluid communication with the cavity 626 of the valve body 610. Similarly, the effluent outlet port 612 can define a cavity 628 extending from a first end 630 outside the valve body 610 to a second end 632 disposed inside the valve body 610. The cavity 628 of the effluent outlet port 612 may extend through the bonnet 614 in a direction generally parallel or co-linear with the longitudinal axis 624 of the spool valve 600 to define an opening from the exterior of the valve body 610 to an interior chamber or cavity 626 of the valve body 610 .

[0110] A generally cylindrical valve core or piston 634 may be slidably disposed within the interior cavity 626 of the valve body 610. The valve core 634 may be actuated along or in line with the longitudinal axis 624 of the spool valve 600. In the first or closed configuration ( Fig.15 ), the valve core 634 can be positioned to block or close the cavity 618 of the effluent inlet port 608. This can prevent the effluent from entering the cavity 626 of the valve body 610. In the second or open configuration ( Fig.16 ), the valve core 634 can be displaced along the longitudinal axis 624 to align the fluid path through the valve core 634 with the cavity 618 to fluidly connect the cavity 618 of the effluent inlet port 608 with the cavity 628 of the effluent outlet port 612.

[0111] The diameter of the valve core 634 can vary over its length. For example, the valve core 634 can include a middle region 654 or annular groove having a first outer diameter, longitudinally spaced raised regions 648a, 648b (collectively 648) adjacent to the first end 646 of the valve core 634, and longitudinally spaced raised regions 652a, 652b (collectively 652) adjacent to the second end 650 of the valve core 634. Each of the middle region 654 and the raised regions 648, 652 can extend around the circumference of the valve core 634. The raised regions 648, 652 can have an outer diameter that is greater than the first outer diameter of the middle region 654. In some examples, the raised regions 648, 652 can have an outer diameter that is substantially the same as the inner diameter of the inner cavity 626 so as to form a fluid-tight seal at the cavity 618 of the effluent inlet port 608 when the valve core 634 is in the closed configuration. However, in other embodiments, the raised areas 648, 652 may have an outer diameter that is smaller than the inner diameter of the inner cavity 626. In some embodiments, the valve core 634 may be formed of a resilient material, such as but not limited to rubber, silicone, etc., to allow portions of the valve core 634 to contact the inner surface of the valve body 610 and create a fluid-tight seal.

[0112] The valve core 634 can include a plurality of O-rings or other sealing members 640a, 640b, 640c (collectively 640) positioned at intervals along the length of the valve core 634. The O-rings 640 can be positioned between the outer surface 642 of the valve core 634 and the inner surface 644 of the valve body 610 to provide a fluid-tight seal between the valve core 634 and the valve body 610. The first O-ring 640a can be positioned adjacent to the first end 646 of the valve core 634. The first O-ring 640a can be positioned in a recess defined by a pair of raised areas 648a, 648b. The first O-ring 640a can be configured to substantially fluidically isolate the fluid inlet port 606 from the effluent inlet port 608 and the effluent outlet port 612. The second O-ring 640b and the third O-ring 640c can be positioned adjacent to the second end 650 of the valve core 634. The second and third O-rings 640b, 640c can be positioned within the recess defined by the plurality of raised areas 652a, 652b, 652c. Fig.15 ), the second and third O-rings 640b, 640c may be positioned on the first and second sides of the second end 622 of the cavity 618 of the effluent inlet port 608, respectively, such that the cavity 618 of the effluent inlet port 608 is positioned between the second and third O-rings 640b, 640c. The second and third O-rings 640b, 640c may fluidly isolate the cavity 618 of the effluent inlet port 608 from the cavity 626 of the valve body 610 when the valve 600 is in the closed configuration. For example, when the valve 600 is in the closed configuration, the fluid may not leave the cavity 618 of the effluent inlet port 608.

[0113] The intermediate region 654 of the valve core 634 can have an outer diameter that is smaller than the diameter of the raised regions 648, 652, which can be in the second or open configuration ( Fig.16 ) to align with the cavity 618 of the effluent inlet port 608. It should be noted that in the first or closed configuration, the intermediate region 654 of the valve core 634 can be moved to a position offset from the cavity 618 of the effluent inlet port 608 to fluidly isolate the effluent inlet port 608 from the effluent outlet port 612 via the second and third O-rings 640b, 640c. Moving the valve core 634 to align the intermediate region 654 with the cavity 618 of the effluent inlet port 608 can fluidly couple the cavity 618 of the effluent inlet port 608 with the cavity 628 of the effluent outlet port 612. For example, the valve core 634 can include one or more holes or apertures 636 extending from the outer surface of the valve core 634 to the inner cavity 638 of the valve core 634. The apertures 636 can be spaced circumferentially and / or axially around the intermediate region 654 as desired. When the fluid passes through the cavity 618 of the effluent inlet port 608, the fluid can enter the cavity 626 of the valve body 610. The fluid can then pass through one or more holes 636 of the valve core 634 and enter the inner cavity 638 of the valve core 634. The inner cavity 638 of the valve core 634 can be in fluid communication with the cavity 628 of the effluent outlet port 612 to allow the fluid to exit the valve body 610, as shown at flow path 656.

[0114] It is contemplated that the radially inwardly extending wall 658 of the valve core 634 may extend across the interior cavity 638 thereof to substantially fluidly isolate the first end 646 of the valve core 634 from the second end of the valve core 650. An orifice 660 may extend through the thickness of the radially inwardly extending wall 658 to allow a small amount of fluid received at the fluid inlet port 606 to pass into the interior cavity 638 of the valve core 634. This may allow pressure to be released when the roller pump 240 is turned off and the valve moves from an open configuration to a closed configuration, as will be described in greater detail herein.

[0115] A spring 662 or other biasing mechanism can be disposed within the interior cavity 626 of the valve body 610, such as opposite the fluid inlet port 606. The spring 662 can extend from a first end 664 to a second end 666, the first end 472 being configured to be positioned adjacent to and / or in contact with a second end portion 668 of the valve core 634, and the second end 474 being configured to be positioned adjacent to and / or in contact with an inner surface 670 of a bonnet 614 of the spool valve 600. In the absence of an external force, the spring 662 can be configured to bias the valve core 634 toward a first or closed configuration. The bonnet 614 can be configured to threadably engage the valve body 610 via a set of mating threads 672, 674. The bonnet 614 can be provided as a separate component assembled with the valve body 610. Although the bonnet 614 is shown and described as having a threaded coupling 672, 674 with the valve body 610, the bonnet 614 may be secured to the valve body 610 using any desired means, such as, but not limited to, adhesives, friction fits, mechanical engagements, welding, soldering, brazing, threaded engagements, etc. The bonnet 614 may have an outer diameter similar to the outer diameter of the first end region of the valve body 610. The bonnet 614 may include an internal threaded engagement 672 configured to engage an external threaded engagement 674 formed on an outer surface of the valve body 610. In other embodiments, at least one of the fluid inlet port 606 and / or the effluent inlet port 608 may be formed as a separate component or coupled to a separate component that is subsequently assembled with the valve body 610 in a manner similar to the bonnet 614.

[0116] The valve core 634 can be actuated to Fig.16 606. In the open configuration shown, the fluid flows through the fluid inlet port 606. For example, the fluid inlet port 606 can define a cavity 676 that extends from a first end 678 outside the valve body to a second end 680 disposed inside the valve body 410. The fluid inlet port 606 can extend along or co-linearly with the longitudinal axis 624 of the spool valve 600. The cavity 676 can be in fluid communication with the inner cavity 626 of the valve body 610. The fluid can flow through the fluid inlet tube 490 and into the cavity 676 of the fluid inlet port 606 in the inner cavity 626. Once sufficient fluid pressure accumulates within the inner cavity 626 against the first side of the radially inwardly extending wall 658 of the valve core 634, the fluid can push the valve core 634 toward the second end 604 of the spool valve 600 and compress the spring 662 to move the valve core 634 from the first closed configuration ( Fig.15 ) moves to the second opening pattern ( Fig.16). For example, sufficient fluid pressure can be the amount of pressure required to overcome the biasing force of the spring 662. When the valve core 634 is actuated toward the second end 604, the second end 650 of the valve core 634 can contact the annular wall 682 of the bonnet 614 to provide a mechanical stop that is spaced to align the intermediate region 654 with the cavity 618 of the effluent inlet port 608. In some cases, the cavity 628 of the effluent outlet port 612 can allow air to escape from the inner cavity 626 when the valve core 634 moves toward the second end 604 of the sliding valve 600. In addition, the cavity 628 of the effluent outlet port 612 can allow air to enter the inner cavity 626 when the valve core 634 moves toward the first end 602 of the sliding valve 600.

[0117] The sliding valve 600 can be configured to open (e.g., actuate the valve core 634) substantially synchronously when the thrombectomy catheter 58 is used. For example, when the clinician activates the drive unit 12 (e.g., operates a foot switch (not explicitly shown) on the drive unit 12), both the pump 56 and the roller pump 240 are activated. In some cases, when the clinician activates the drive unit 12, the pump 56 can be automatically activated simultaneously or successively with the roller pump 240. Because a portion 494 of the fluid inlet tube 490 is disposed within the roller pump 240, actuation of the roller pump 240 drives the fluid through the fluid inlet tube 490 and into the inner cavity 626 of the valve body 610 via the fluid inlet port 606. As described above, the fluid can be saline, ambient air, or other fluid. The fluid pushes the valve core 634 to an open configuration ( Fig.16) and allows free flow of effluent through the effluent waste tube 68, along the flow path 656 from the effluent inlet port 608 to the effluent outlet port 612, through the sliding valve 600 and into the effluent collection bag 28. For example, the flow of effluent is not limited by the speed of the roller pump 240. Instead, the effluent can flow freely at a rate that achieves fluid flow balance within the system. Since there is no fluid outlet near the first end 646 of the valve core 634, fluid flow may cause the roller pump 240 to stop, and no additional fluid will be delivered to the inner cavity 626 of the sliding valve 600, thereby maintaining the valve core 634 in the open position. However, the hole 660 in the radially inwardly extending wall 658 can allow a small amount of fluid to pass from the first side of the radially inwardly extending wall 658 and enter the inner cavity 638 of the valve core 634. When the clinician deactivates the drive unit 12 (e.g., releases the foot switch) to stop operation of the thrombectomy catheter 58, the pump 56 and the roller pump 240 are deactivated, thereby stopping the inflow of fluid to the thrombectomy catheter 58. Because the roller pump 240 is not a perfect pump, pressure may be released from the lumen 626, and the spring 662 may again bias the valve core 634 toward the first end 602 and the closed configuration to stop the flow of effluent through the valve 600 to the effluent waste bag 28. It is also contemplated that the hole 660 defining the leak path in the radially inwardly extending wall 658 may allow a small amount of fluid to pass from the first side of the radially inwardly extending wall 658 and enter the lumen 638 of the valve core 634 after the roller pump 240 is deactivated to release pressure from the lumen 626. The aperture 660 can be sized so that a pressure differential can be maintained across the valve core 634 to actuate the valve core 634 to the open position when the roller pump 240 is running, and when the roller pump 240 is stopped, the fluid in the chamber 638 is exhausted to release the pressure and thereby close the valve 600 (i.e., allowing the valve core 634 to move to the closed position). For example, the diameter of the aperture 660 can be in the range of about 0.1 mm to about 0.2 mm. It is also contemplated that the spool valve 600 can include any of the pressure relief features or structures described herein.

[0118] Fig.17 is a perspective view of another illustrative spool valve 700. Generally, spool valve 700 may be similar in form and function to the spool valve 700 described with reference to FIG. Figures 16 to 18 The spool valve 600 described above. However, the spool valve 700 may include an alternative pressure relief mechanism. The spool valve 700 may include a valve body 710, which in some cases may have a generally tubular cylindrical structure extending from a first end 702 to a second end 704. A fluid inlet port 706 may extend from the first end 702. The fluid inlet port 706 may be configured to be fluidically coupled to a fluid inlet pipe, such as a Figure 5The fluid inlet pipe 490 described. For example, the fluid inlet port 706 can be configured so that the fluid inlet pipe 490 can be disposed on and around the fluid inlet port 706, or can be configured so that the fluid inlet pipe 490 extends within the fluid inlet port 706 as needed. In other cases, the fluid inlet pipe 490 can be threadedly connected to the fluid inlet port 706. The fluid inlet port 706 can be formed as a single integral structure with the valve body 710. In other embodiments, the fluid inlet port 706 can be removably coupled to the valve body 710 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the fluid inlet port 706 can include a pipe barb including one or more raised ridges 716a. The diameter of the raised ridges 716a can increase toward the valve body 710. This can facilitate assembly of the fluid inlet pipe 490 with the fluid inlet port 706 while preventing the fluid inlet pipe 490 from being accidentally removed from the fluid inlet port 706.

[0119] The effluent inlet port 708 may extend from the valve body 710, such as from a curved sidewall of the valve body 710. The effluent outlet port 712 may extend from the second end 704 of the valve body 710. For example, the effluent inlet port 708 and the effluent outlet port 712 may extend at angles substantially orthogonal to each other. Each of the effluent inlet port 708 and the effluent outlet port 712 may be configured to be fluidly coupled to a portion of the effluent waste pipe 68. The first portion of the effluent waste pipe 68 may be fluidly coupled to the effluent inlet port 708 (e.g., disposed above or within the effluent inlet port 708) and extend therefrom as desired. The second portion of the effluent waste pipe 68 may be fluidly coupled to the effluent outlet port 712 (e.g., disposed above or within the effluent outlet port 712) and extend therefrom as desired. The effluent inlet port 708 and the effluent outlet port 712 can be fluidly isolated from the fluid inlet port 706. In some cases, the effluent inlet port 708 and the effluent outlet port 712 can be substantially fluidly isolated from the fluid inlet port 706. For example, when the effluent inlet port 708 and the effluent outlet port 712 are substantially fluidly isolated from the fluid inlet port 706, a small pressure relief fluid path can extend from the fluid inlet port 706 through the spool valve 400 to the effluent inlet port 708 and / or the effluent outlet port 712, which allows pressure in the fluid inlet tube 490 to be released from the spool valve 400 when the roller pump 240 is turned off to close the spool valve 700, however this is not required.

[0120] In some cases, the effluent inlet port 708 and the effluent outlet port 712 can be positioned so that their respective flow paths are approximately 90° relative to each other. Other positions and / or configurations of the effluent inlet port 708 and the effluent outlet port 712 can be used as needed. The effluent inlet port 708 can be formed as a single integral structure with the valve body 710. In other embodiments, the effluent inlet port 708 can be removably coupled to the valve body 710 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the effluent outlet port 712 can be removably coupled to the valve body 710 using, for example, a removable threaded bonnet 714. Other coupling methods such as, but not limited to, press fits, snap fits, friction fits, snap rings, etc. can be used as needed. In other examples, the effluent outlet port 712 can be formed as a single integral structure with the valve body 710. One or both of the effluent inlet port 708 and the effluent outlet port 712 may include one or more raised ridges 716b, 716c. The diameter of the raised ridges 716b, 716c may increase toward the valve body 710. This may facilitate assembly of the effluent waste tube 68 with the effluent inlet port 708 and / or the effluent outlet port 712 while preventing accidental removal of the effluent waste tube 68 from the effluent inlet port 708 and / or the effluent outlet port 712.

[0121] As described above, the spool valve 700 can be positioned in line with the effluent waste tube 68. For example, the effluent inlet port 708 can be positioned downstream of the connecting manifold assembly 62, and the effluent outlet port 712 can be positioned upstream of the effluent collection bag 28. For example, effluent can flow from the thrombectomy catheter 58 through the effluent return tube 66, through the connecting manifold assembly 62, and into the effluent waste tube 68. Once in the effluent waste tube 68, the effluent can pass through the spool valve 700 before entering the effluent collection bag 28. It is contemplated that positioning the effluent outlet port 712 at a non-parallel angle to the effluent inlet port 708 or in line with the fluid inlet port 706 can allow the spool valve 700 to be suspended with its longitudinal axis extending in a generally vertical direction. This, in turn, can allow the fluid inlet port 706 to be aligned with the fluid inlet tube 490. It is also contemplated that placing the effluent outlet port 712 in line with the fluid inlet port 706 may allow the waste bag 28 to be easily placed on the drip tray 24 of the console.

[0122] Additional references Fig.18 , which is a cross-sectional view of the spool valve 700 in a first or closed configuration, and reference Fig.19, which is a cross-sectional view of the spool valve 700 in a second or open configuration, the effluent inlet port 708 can define a cavity 718 extending from a first end 720 exterior to the valve body 710 to a second end 722 disposed within the valve body 710. The cavity 718 of the effluent inlet port 708 can extend through the sidewall of the valve body 710 in a direction generally orthogonal to the longitudinal axis 724 of the spool valve 700 to define an opening from the exterior of the valve body 710 to an interior chamber or cavity 726 of the valve body 710. The cavity 718 of the effluent inlet port 708 can be in selective fluid communication with the cavity 726 of the valve body 710. Similarly, the effluent outlet port 712 can define a cavity 728 extending from a first end 730 exterior to the valve body 710 to a second end 732 disposed within the valve body 710. The cavity 728 of the effluent outlet port 712 may extend through the bonnet 714 in a direction generally parallel or co-linear with the longitudinal axis 724 of the spool valve 700 to define an opening from the exterior of the valve body 710 to an interior chamber or cavity 726 of the valve body 710 .

[0123] A generally cylindrical valve core or piston 734 may be slidably disposed within the interior cavity 726 of the valve body 710. The valve core 734 may be actuated along or in line with the longitudinal axis 724 of the spool valve 700. In the first or closed configuration ( Fig.18 ), the valve core 734 can be positioned to block or close the cavity 718 of the effluent inlet port 708. This can prevent the effluent from entering the cavity 726 of the valve body 710. In the second or open configuration ( Fig.19 ), the valve core 734 can be displaced along the longitudinal axis 724 to align the fluid path through the valve core 734 with the cavity 718 to fluidly connect the cavity 718 of the effluent inlet port 708 with the cavity 728 of the effluent outlet port 712.

[0124] The diameter of the valve core 734 can vary over its length. For example, the valve core 734 can include a middle region 754 or annular groove having a first outer diameter, longitudinally spaced raised regions 748a, 748b (collectively 748) adjacent to the first end 746 of the valve core 734, and longitudinally spaced raised regions 752a, 752b (collectively 752) adjacent to the second end 750 of the valve core 734. Each of the middle region 754 and the raised regions 748, 752 can extend around the circumference of the valve core 734. The raised regions 748, 752 can have an outer diameter that is greater than the first outer diameter of the middle region 754. In some examples, the raised regions 748, 752 can have an outer diameter that is substantially the same as the inner diameter of the inner cavity 726 so as to form a fluid-tight seal at the cavity 718 of the effluent inlet port 708 when the valve core 734 is in the closed configuration. However, in other embodiments, the raised areas 748, 752 may have an outer diameter that is smaller than the inner diameter of the lumen 726. In some embodiments, the valve core 734 may be formed of a resilient material, such as but not limited to rubber, silicone, etc., to allow portions of the valve core 734 to contact the inner surface of the valve body 710 and create a fluid-tight seal.

[0125] The valve core 734 may include a plurality of O-rings or other sealing members 740a, 740b, 740c (collectively 740) positioned at intervals along the length of the valve core 734. The O-rings 740 may be positioned between an outer surface 742 of the valve core 734 and an inner surface 744 of the valve body 710 to provide a fluid-tight seal between the valve core 734 and the valve body 710. The first O-ring 740a may be positioned adjacent to the first end 746 of the valve core 734. The first O-ring 740a may be positioned within a recess defined by a pair of raised areas 748a, 748b. The first O-ring 740a may be configured to substantially fluidically isolate the fluid inlet port 706 from the effluent inlet port 708 and the effluent outlet port 712. The second O-ring 740b and the third O-ring 740c may be positioned adjacent to the second end 750 of the valve core 734. The second and third O-rings 740b, 740c can be positioned within the recess defined by the plurality of raised areas 752a, 752b, 752c. Fig.18 ), the second and third O-rings 740b, 740c may be positioned on the first and second sides of the second end 722 of the cavity 718 of the effluent inlet port 708, respectively, such that the cavity 718 of the effluent inlet port 708 is positioned between the second and third O-rings 740b, 740c. The second and third O-rings 740b, 740c may fluidly isolate the cavity 718 of the effluent inlet port 708 from the cavity 726 of the valve body 710 when the valve 700 is in the closed configuration. For example, when the valve 700 is in the closed configuration, the fluid may not leave the cavity 718 of the effluent inlet port 708.

[0126] The intermediate region 754 of the valve core 734 can have an outer diameter that is smaller than the diameter of the raised regions 748, 752, which can be in the second or open configuration ( Fig.19 ) to align with the cavity 718 of the effluent inlet port 708. It should be noted that in the first or closed configuration, the intermediate region 754 of the valve core 734 can be moved to a position offset from the cavity 718 of the effluent inlet port 708 so that the effluent inlet port 708 is fluidly isolated from the effluent outlet port 712 via the second and third O-rings 740b, 740c. Moving the valve core 734 to align the intermediate region 754 with the cavity 718 of the effluent inlet port 708 can fluidly couple the cavity 718 of the effluent inlet port 708 with the cavity 728 of the effluent outlet port 712. For example, the valve core 734 can include one or more holes or apertures 736 extending from the outer surface of the valve core 734 to the inner cavity 738 of the valve core 734. As desired, the apertures 736 can be spaced circumferentially and / or axially around the intermediate region 754. When the fluid passes through the cavity 718 of the effluent inlet port 708, the fluid can enter the cavity 726 of the valve body 710. The fluid can then pass through one or more holes 736 of the valve core 734 and enter the inner cavity 738 of the valve core 734. The inner cavity 738 of the valve core 734 can be in fluid communication with the cavity 728 of the effluent outlet port 712 to allow the fluid to exit the valve body 710, as shown at flow path 756.

[0127] It is contemplated that the radially inwardly extending wall 758 of the valve core 734 may extend across its lumen 738 so that the first end 746 of the valve core 734 is substantially fluidly isolated from the second end of the valve core 750. A small hole 760 may extend through the thickness of the radially inwardly extending wall 758 to allow air and / or fluid to pass through the hole 760 to prime the spool valve 700. However, the hole 760 may be sized to exclude the flow of liquid fluid therethrough. Alternatively or in addition, the hole 760 may include a hydrophobic membrane disposed across its opening. The hydrophobic membrane may allow air to pass through the hole 760 while excluding the flow of water or saline therethrough. Alternatively, the hole 760 may be sized or configured as a leak path to allow a small amount of fluid received at the fluid inlet port 706 to enter the lumen 738 of the valve core 734 and reach the cavity 728 of the effluent outlet port 712. This may allow pressure to be released when roller pump 240 is turned off and the valve moves from an open configuration to a closed configuration, as will be described in greater detail herein.

[0128] A spring 762 or other biasing mechanism can be disposed within the interior cavity 726 of the valve body 710, such as opposite the fluid inlet port 706. The spring 762 can extend from a first end 764 to a second end 766, the first end 472 being configured to be positioned adjacent to and / or in contact with a second end portion 768 of the valve core 734, and the second end 474 being configured to be positioned adjacent to and / or in contact with an inner surface 770 of a bonnet 714 of the spool valve 700. In the absence of an external force, the spring 762 can be configured to bias the valve core 734 toward a first or closed configuration. The bonnet 714 can be configured to threadably engage the valve body 710 via a set of mating threads 772, 774. The bonnet 714 can be provided as a separate component assembled with the valve body 710. Although the bonnet 714 is shown and described as having a threaded coupling 772, 774 with the valve body 710, the bonnet 714 may be secured to the valve body 710 using any desired means, such as, but not limited to, adhesives, friction fits, mechanical engagements, welding, soldering, brazing, threaded engagements, etc. The bonnet 714 may have an outer diameter similar to the outer diameter of the first end region of the valve body 710. The bonnet 714 may include an internal threaded engagement 772 configured to engage an external threaded engagement 774 formed on an outer surface of the valve body 710. In other embodiments, at least one of the fluid inlet port 706 and / or the effluent inlet port 708 may be formed as a separate component or coupled to a separate component that is subsequently assembled with the valve body 710 in a manner similar to the bonnet 714.

[0129] The valve core 734 can be actuated to Fig.19 4 and 5. In the open configuration shown, the fluid flows through the fluid inlet port 706. For example, the fluid inlet port 706 can define a cavity 776 extending from a first end 778 outside the valve body to a second end 780 disposed inside the valve body 410. The fluid inlet port 706 can extend along or co-linearly with the longitudinal axis 724 of the spool valve 700. The cavity 776 can be in fluid communication with the inner cavity 726 of the valve body 710. The fluid can flow through the fluid inlet tube 490 and into the cavity 776 of the fluid inlet port 706 in the inner cavity 726. Once sufficient fluid pressure accumulates within the inner cavity 726 against the first side of the radially inwardly extending wall 758 of the valve core 734, the fluid can push the valve core 734 toward the second end 704 of the spool valve 700 and compress the spring 762 to move the valve core 734 from the first closed configuration ( Fig.18 ) moves to the second opening pattern ( Fig.19). For example, the sufficient fluid pressure can be the amount of pressure required to overcome the biasing force of the spring 762. When the valve core 734 is actuated toward the second end 704, the second end 750 of the valve core 734 can contact the annular wall 782 of the bonnet 714 to provide a mechanical stop that is spaced to align the intermediate region 754 with the cavity 718 of the effluent inlet port 708. In some cases, the cavity 728 of the effluent outlet port 712 can allow air to escape from the inner cavity 726 when the valve core 734 moves toward the second end 704 of the sliding valve 700. In addition, the cavity 728 of the effluent outlet port 712 can allow air to enter the inner cavity 726 when the valve core 734 moves toward the first end 702 of the sliding valve 700.

[0130] The sliding valve 700 can be configured to open (e.g., actuate the valve core 734) substantially synchronously when the thrombectomy catheter 58 is used. For example, when the clinician activates the drive unit 12 (e.g., operates a foot switch (not explicitly shown) on the drive unit 12), both the pump 56 and the roller pump 240 are activated. In some cases, when the clinician activates the drive unit 12, the pump 56 can be automatically activated simultaneously or successively with the roller pump 240. Because a portion 494 of the fluid inlet tube 490 is disposed within the roller pump 240, actuation of the roller pump 240 drives the fluid through the fluid inlet tube 490 and into the inner cavity 726 of the valve body 710 via the fluid inlet port 706. As described above, the fluid can be saline, ambient air, or other fluid. The fluid pushes the valve core 734 to an open configuration ( Fig.19 ) and allows free flow of effluent through the effluent waste tube 68, along the flow path 756 from the effluent inlet port 708 to the effluent outlet port 712, through the slide valve 700, and into the effluent collection bag 28. For example, the flow of effluent is not limited by the speed of the roller pump 240. Instead, the effluent can flow freely at a rate that achieves fluid flow balance within the system. Since there is no fluid outlet near the first end 746 of the valve core 734, fluid flow may cause the roller pump 240 to stop, and no additional fluid will be delivered to the inner cavity 726 of the slide valve 700, thereby maintaining the valve core 734 in the open position. When the clinician deactivates the drive unit 12 (e.g., releases the foot switch) to stop the operation of the thrombectomy catheter 58, the pump 56 and the roller pump 240 are deactivated, thereby stopping the inflow of fluid to the thrombectomy catheter 58. Since roller pump 240 is not a perfect pump, pressure may release from lumen 726 and spring 762 may again bias valve element 734 toward first end 702 and the closed configuration to stop the flow of effluent through valve 700 to effluent waste bag 28 .

[0131] A small tubular member, such as a hypotube 790, may be positioned in the lumen of the fluid inlet tube 490 through at least the portion of the fluid inlet tube 490 that passes through the roller pump 240. In some examples, the hypotube 790 may extend into the lumen 776 of the fluid inlet port 706. Placing the hypotube 790 within the lumen of the tube 490 may provide a fluid path 792 (e.g., the lumen of the hypotube 790) from a location upstream of the roller pump 240 through the hypotube 790 to a location downstream of the roller pump 240. The hypotube 790 may be constructed (e.g., possessing sufficient hoop strength) such that the lumen of the hypotube does not collapse or occlude within the roller pump 240. Thus, a small leak path may be formed from the lumen 726 of the valve 700 through the lumen 792 of the hypotube 790 and through the roller pump 240, such that when the roller pump 240 is deactivated or stopped, fluid in the lumen 726 may pass through the lumen 792 of the hypotube 790 in a retrograde direction. In some examples, the hypotube 790 can prevent the roller 242 from completely occluding the collapsed or compressed cavity of the tube 490 between the roller 242 and the housing 246, thereby leaving a cavity similar in form and function to that described with respect to FIG. Fig.12 An additional leakage channel of the leakage channel 510 .

[0132] It is also contemplated that the spool valve 700 may include any of the pressure relief features or structures described herein. For example, it is also contemplated that the aperture 760 may be configured to define a leak path through the radially inwardly extending wall 758 to allow a small amount of fluid to pass from a first side of the radially inwardly extending wall 758 and enter the lumen 738 of the valve core 734 after the roller pump 240 is deactivated to release pressure from the lumen 726. The aperture 760 may be sized so that a pressure differential against the valve core 734 may be maintained to actuate the valve core 734 to an open position when the roller pump 240 is in operation, and when the roller pump 240 is stopped, the fluid in the lumen 738 is exhausted to release pressure and thereby close the valve 700 (i.e., allowing the valve core 734 to move to a closed position). For example, the diameter of the aperture 760 may be in the range of about 0.1 mm to about 0.2 mm.

[0133] Fig. 20 800. The spool valve 800 may include a valve body 810, which in some cases may have a generally tubular cylindrical structure extending from a first end 802 to a second end 804. A fluid inlet port 806 may extend from the first end 802. The fluid inlet port 806 may be configured to be fluidically coupled to a fluid inlet tube 490, such as with respect to Figure 5The fluid inlet pipe 490 described. For example, the fluid inlet port 806 can be configured so that the fluid inlet pipe 490 can be disposed above and around the fluid inlet port 806, or can be configured so that the fluid inlet pipe 490 extends within the fluid inlet port 806 as needed. In other cases, the fluid inlet pipe 490 can be threadedly connected to the fluid inlet port 806. The fluid inlet port 806 can be formed as a single integral structure with the valve body 810. In other embodiments, the fluid inlet port 806 can be removably coupled to the valve body 810 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the fluid inlet port 806 can include a pipe barb including one or more raised ridges 816a. The diameter of the raised ridges 816a can increase toward the valve body 810. This can facilitate assembly of the fluid inlet pipe 490 with the fluid inlet port 806 while preventing the fluid inlet pipe 490 from being accidentally removed from the fluid inlet port 806.

[0134] The effluent inlet port 808 and the effluent outlet port 812 can extend from the valve body 810, such as extending from the curved sidewall of the valve body 810. Each of the effluent inlet port 808 and the effluent outlet port 812 can be configured to be fluidly coupled to a portion of the effluent waste pipe 68. A first portion of the effluent waste pipe 68 can be fluidly coupled to the effluent inlet port 808 (e.g., disposed above or within the effluent inlet port 808) and extend therefrom as desired. A second portion of the effluent waste pipe 68 can be fluidly coupled to the effluent outlet port 812 (e.g., disposed above or within the effluent outlet port 812) and extend therefrom as desired. The effluent inlet port 808 and the effluent outlet port 812 can be fluidly isolated from the fluid inlet port 806. In some cases, the effluent inlet port 808 and the effluent outlet port 812 can be substantially fluidly isolated from the fluid inlet port 806. For example, when the effluent inlet port 808 and the effluent outlet port 812 are substantially fluidically isolated from the fluid inlet port 806, a small pressure relief fluid path may extend from the fluid inlet port 806 through the slide valve 800 to the effluent inlet port 808 and / or the effluent outlet port 812, which allows pressure in the fluid inlet pipe 490 to be released from the slide valve 800 to close the slide valve 800, however this is not required.

[0135] In some cases, the effluent inlet port 808 and the effluent outlet port 812 can be positioned on opposite sides of the valve body 810, such as about 180 ° from each other. In some cases, the effluent inlet port 808 can extend parallel to the effluent outlet port 812, but axially displaced from the effluent outlet port 812. In some cases, the effluent inlet port 808 and the effluent outlet port 812 can be axially displaced from each other along the longitudinal axis 824 of the valve body 810 so that they do not share a common axis. For example, the effluent inlet port 808 can be positioned closer to the second end 804 of the valve body 810 than the effluent outlet port 812. Alternatively, the effluent inlet port 808 can be positioned closer to the first end 802 of the valve body 810 than the effluent outlet port 812. Other positions and / or configurations of the effluent inlet port 808 and the effluent outlet port 812 can be used as needed. The effluent inlet port 808 can be formed as a single unitary structure with the valve body 810. In other embodiments, the effluent inlet port 808 can be removably coupled to the valve body 810 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc., as desired. Similarly, the effluent outlet port 812 can be formed as a single unitary structure with the valve body 810. In other embodiments, the effluent outlet port 812 can be removably coupled to the valve body 810 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc., as desired. One or both of the effluent inlet port 808 and the effluent outlet port 812 can include one or more raised ridges 816b, 816c. The diameter of the raised ridges 816b, 816c can increase toward the valve body 810. This may facilitate assembly of the effluent waste tube 68 with the effluent inlet port 808 and / or the effluent outlet port 812 while preventing accidental removal of the effluent waste tube 68 from the effluent inlet port 808 and / or the effluent outlet port 812 .

[0136] As described above, the spool valve 800 can be positioned in line with the effluent waste tube 68. For example, the effluent inlet port 808 can be positioned downstream of the connection manifold assembly 62, and the effluent outlet port 812 can be positioned upstream of the effluent collection bag 28. For example, effluent can flow from the thrombectomy catheter 58 through the effluent return tube 66, through the connection manifold assembly 62, and into the effluent waste tube 68. Once in the effluent waste tube 68, the effluent can pass through the spool valve 800 before entering the effluent collection bag 28.

[0137] Additional references Fig.21 , which is a cross-sectional view of the spool valve 800 in a first or closed configuration, and reference Fig. 22, which is a cross-sectional view of the spool valve 800 in a second or open configuration, the effluent inlet port 808 can define a cavity 818 extending from a first end 820 exterior to the valve body 810 to a second end 822 disposed within the valve body 810. The cavity 818 of the effluent inlet port 808 can extend through the sidewall of the valve body 810 in a direction generally orthogonal to the longitudinal axis 824 of the spool valve 800 to define an opening from the exterior of the valve body 810 to an interior chamber or cavity 826 of the valve body 810. The cavity 818 of the effluent inlet port 808 can be in selective fluid communication with the cavity 826 of the valve body 810. Similarly, the effluent outlet port 812 can define a cavity 828 extending from a first end 830 exterior to the valve body 810 to a second end 832 disposed within the valve body 810. The cavity 828 of the effluent outlet port 812 may extend through the sidewall of the valve body 810 in a direction generally orthogonal to the longitudinal axis 824 of the spool valve 800 to define an opening from the exterior of the valve body 810 to an interior chamber or cavity 826 of the valve body 810 .

[0138] A generally cylindrical valve core or piston 834 may be slidably disposed within the interior cavity 826 of the valve body 810. The valve core 834 may be actuated along or in line with the longitudinal axis 824 of the spool valve 800. In the first or closed configuration ( Fig.21 ), the valve core 834 can be positioned to block or close the cavity 818 of the effluent inlet port 808. This can prevent the effluent from entering the cavity 826 of the valve body 810. In the second or open configuration ( Fig. 22 ), the valve core 834 can be displaced along the longitudinal axis 824 to align the fluid path through the valve core 834 with the cavity 818 to fluidly connect the cavity 818 of the effluent inlet port 808 with the cavity 828 of the effluent outlet port 812.

[0139] The diameter of the valve core 834 can vary over its length. For example, the valve core 834 can include a middle region 854 or annular groove having a first outer diameter, longitudinally spaced raised regions 848a, 848b (collectively 848) adjacent to the first end 846 of the valve core 834, and longitudinally spaced raised regions 852a, 852b (collectively 852) adjacent to the second end 850 of the valve core 834. Each of the middle region 854 and the raised regions 848, 852 can extend around the circumference of the valve core 834. The raised regions 848, 852 can have an outer diameter that is greater than the first outer diameter of the middle region 854. In some examples, the raised regions 848, 852 can have an outer diameter that is substantially the same as the inner diameter of the inner cavity 826 so as to form a fluid-tight seal at the cavity 818 of the effluent inlet port 808 when the valve core 834 is in the closed configuration. However, in other embodiments, the raised areas 848, 852 may have an outer diameter that is smaller than the inner diameter of the lumen 826. In some embodiments, the valve core 834 may be formed of a resilient material, such as but not limited to rubber, silicone, etc., to allow portions of the valve core 834 to contact the inner surface of the valve body 810 and create a fluid-tight seal.

[0140] The valve core 834 may include a plurality of O-rings or other sealing members 840a, 840b, 840c (collectively 840) positioned at intervals along the length of the valve core 834. The O-rings 840 may be positioned between the outer surface 842 of the valve core 834 and the inner surface 844 of the valve body 810 to provide a fluid-tight seal between the valve core 834 and the valve body 810. The first O-ring 840a may be positioned adjacent to the first end 846 of the valve core 834. The first O-ring 840a may be positioned within a recess defined by a pair of raised areas 848a, 848b. The first O-ring 840a may be configured to substantially fluidically isolate the fluid inlet port 806 from the effluent inlet port 808 and the effluent outlet port 812. The second O-ring 840b and the third O-ring 840c may be positioned adjacent to the second end 850 of the valve core 834. The second and third O-rings 840b, 840c can be positioned within the recess defined by the plurality of raised areas 852a, 852b, 852c. Fig.21 ), the second and third O-rings 840b, 840c may be positioned on the first and second sides of the second end 822 of the cavity 818 of the effluent inlet port 808, respectively, such that the cavity 818 of the effluent inlet port 808 is positioned between the second and third O-rings 840b, 840c. The second and third O-rings 840b, 840c may fluidly isolate the cavity 818 of the effluent inlet port 808 from the cavity 826 of the valve body 810 when the valve 800 is in the closed configuration. For example, when the valve 800 is in the closed configuration, the fluid may not leave the cavity 818 of the effluent inlet port 808.

[0141] The intermediate region 854 of the valve core 834 can have an outer diameter that is smaller than the diameter of the raised regions 848, 852, which can be in the second or open configuration ( Fig. 22 ) to align with the cavity 818 of the effluent inlet port 808. It should be noted that in the first or closed configuration, the intermediate region 854 of the valve core 834 can be moved to a position offset from the cavity 818 of the effluent inlet port 808 to fluidly isolate the effluent inlet port 808 from the effluent outlet port 812 via the second and third O-rings 840b, 840c. Moving the valve core 834 to align the intermediate region 854 with the cavity 818 of the effluent inlet port 808 can fluidly couple the cavity 818 of the effluent inlet port 808 with the cavity 828 of the effluent outlet port 812. For example, when the fluid passes through the cavity 818 of the effluent inlet port 808, the fluid can enter the cavity 826 of the valve body 810 and the annular space between the outer surface 842 of the valve core 834 and the inner surface 844 of the valve body 810. The cavity 828 of the effluent outlet port 812 can also be in fluid communication with the annular space between the outer surface 842 of the valve core 834 and the inner surface 844 of the valve body 810. Therefore, fluid can flow out of the cavity 826 of the valve body 810 via the cavity 828 of the effluent outlet port 812, as shown at flow path 856.

[0142] It is contemplated that the radially inwardly extending wall 858 of the valve core 834 may extend across its inner cavity 838 to substantially fluidly isolate the first end 846 of the valve core 834 from the second end of the valve core 850. A small hole 860 may extend through the thickness of the wall of the valve core 850, such as through the circumferential wall of the middle region of the valve core 834, to allow air and / or fluid to pass through the hole 860 to prime the spool valve 800. However, the hole 860 may be sized to exclude the flow of liquid fluid therethrough. Alternatively or additionally, the hole 860 may include a hydrophobic membrane disposed across its opening. The hydrophobic membrane may allow air to pass through the hole 860 while excluding the flow of water or saline therethrough. Alternatively, the hole 860 may be sized or configured as a leak path to allow a small amount of fluid received at the fluid inlet port 806 to pass through the circumferential wall of the middle region 854 of the valve core 834 and reach the cavity 828 of the effluent outlet port 812. This may allow pressure to be released when roller pump 240 is turned off and the valve moves from an open configuration to a closed configuration, as will be described in greater detail herein.

[0143] A spring 862 or other biasing mechanism can be disposed within the inner cavity 826 of the valve body 810, such as opposite the fluid inlet port 806. The spring 862 can extend from a first end 864 to a second end 866, the first end 472 being configured to be positioned adjacent to and / or in contact with a second end portion 868 of the valve core 834, and the second end 474 being configured to be positioned adjacent to and / or in contact with an inner surface 870 of a bonnet 814 of the spool valve 800. In the absence of an external force, the spring 862 can be configured to bias the valve core 834 toward a first or closed configuration. The bonnet 814 can be releasably coupled to the valve body 810. For example, the bonnet 814 can be configured to threadably engage the valve body 810 via a set of mating threads 872, 874. The bonnet 814 can be provided as a separate component assembled with the valve body 810. Although the bonnet 814 is shown and described as having a threaded coupling 872, 874 with the valve body 810, the bonnet 814 may be secured to the valve body 810 using any desired means, such as, but not limited to, adhesives, friction fits, mechanical engagements, welding, soldering, brazing, threaded engagements, etc. The bonnet 814 may have an outer diameter similar to the outer diameter of the first end region of the valve body 810. The bonnet 814 may include an internal threaded engagement 872 configured to engage an external threaded engagement 874 formed on an outer surface of the valve body 810. In other embodiments, at least one of the fluid inlet port 806 and / or the effluent inlet port 808 may be formed as a separate component or coupled to a separate component that is subsequently assembled with the valve body 810 in a manner similar to the bonnet 814.

[0144] The valve core 834 can be actuated to Fig. 22 810 , the fluid flows through the fluid inlet port 806. For example, the fluid inlet port 806 can define a cavity 876 extending from a first end 878 outside the valve body to a second end 880 disposed inside the valve body 810. The fluid inlet port 806 can extend along or co-linearly with the longitudinal axis 824 of the spool valve 800. The cavity 876 can be in fluid communication with the inner cavity 826 of the valve body 810. The fluid can flow through the fluid inlet tube 490 and into the cavity 876 of the fluid inlet port 806 in the inner cavity 826. Once sufficient fluid pressure accumulates within the inner cavity 826 against the first side of the radially inwardly extending wall 858 of the valve core 834, the fluid can push the valve core 834 toward the second end 804 of the spool valve 800 and compress the spring 862 to move the valve core 834 from the first closed configuration ( Fig.21 ) moves to the second opening pattern ( Fig. 22). For example, the sufficient fluid pressure can be the amount of pressure required to overcome the biasing force of the spring 862. When the valve core 834 is actuated toward the second end 804, the second end 850 of the valve core 834 can contact the annular wall 882 of the valve cap 814 to provide a mechanical stop that is spaced apart to align the intermediate region 854 with the cavity 818 of the effluent inlet port 808. In some cases, a through hole 884 can extend through the valve cap 814 to allow air to escape from the inner cavity 826 when the valve core 834 moves toward the second end 804 of the sliding valve 800. In addition, the through hole 884 can allow air to enter the inner cavity 826 when the valve core 834 moves toward the first end 802 of the sliding valve 800.

[0145] The sliding valve 800 can be configured to open (e.g., actuate the valve core 834) substantially synchronously when the thrombectomy catheter 58 is used. For example, when the clinician activates the drive unit 12 (e.g., operates a foot switch (not explicitly shown) on the drive unit 12), both the pump 56 and the roller pump 240 are activated. In some cases, when the clinician activates the drive unit 12, the pump 56 can be automatically activated simultaneously or successively with the roller pump 240. Because a portion 494 of the fluid inlet tube 490 is disposed within the roller pump 240, actuation of the roller pump 240 drives the fluid through the fluid inlet tube 490 and into the inner cavity 826 of the valve body 810 via the fluid inlet port 806. As described above, the fluid can be saline, ambient air, or other fluid. The fluid pushes the valve core 834 to an open configuration ( Fig. 22 ) and allows free flow of effluent through the effluent waste tube 68, along the flow path 856 from the effluent inlet port 808 to the effluent outlet port 812, through the slide valve 800, and into the effluent collection bag 28. For example, the flow of effluent is not limited by the speed of the roller pump 240. Instead, the effluent can flow freely at a rate that achieves fluid flow balance within the system. Since there is no fluid outlet near the first end 846 of the valve core 834, fluid flow may cause the roller pump 240 to stop, and no additional fluid will be delivered to the inner cavity 826 of the slide valve 800, thereby maintaining the valve core 834 in an open position. When the clinician deactivates the drive unit 12 (e.g., releases the foot switch) to stop the operation of the thrombectomy catheter 58, the pump 56 and the roller pump 240 are deactivated, thereby stopping the inflow of fluid to the thrombectomy catheter 58. Since roller pump 240 is not a perfect pump, pressure may be released from lumen 826 and spring 862 may again bias valve element 834 toward first end 802 and the closed configuration to stop the flow of effluent through valve 800 to effluent waste bag 28 .

[0146] It is also contemplated that the spool valve 800 may include any of the pressure relief features or structures described herein. For example, it is also contemplated that the aperture 860 may be configured to define a leak path through the circumferential wall of the intermediate region 854 to allow a small amount of fluid to pass from the cavity 876 of the fluid inlet port 806 to the cavity 828 of the effluent outlet port 812 after the roller pump 240 is deactivated to release pressure from the inner cavity 726. The aperture 860 may be sized so that a pressure differential across the valve core 834 may be maintained to actuate the valve core 834 to an open position while the roller pump 240 is running, and when the roller pump 240 is stopped, the fluid in the cavity 738 is exhausted to release pressure and thereby close the valve 800 (i.e., allowing the valve core 834 to move to a closed position). For example, the diameter of the aperture 860 may be in the range of about 0.1 mm to about 0.2 mm.

[0147] Fig.23 900. The spool valve 900 may include a valve body 910, which in some cases may have a generally tubular cylindrical structure extending from a first end 902 to a second end 904. A fluid inlet port 906 may extend from the first end 902. The fluid inlet port 906 may be configured to be fluidically coupled to a fluid inlet tube 490, such as with respect to Figure 5 The fluid inlet pipe 490 described. For example, the fluid inlet port 906 can be configured so that the fluid inlet pipe 490 can be disposed above and around the fluid inlet port 906, or can be configured so that the fluid inlet pipe 490 extends within the fluid inlet port 906 as needed. In other cases, the fluid inlet pipe 490 can be threadedly connected to the fluid inlet port 906. The fluid inlet port 906 can be formed as a single integral structure with the valve body 910. In other embodiments, the fluid inlet port 906 can be removably coupled to the valve body 910 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc. as needed. In some embodiments, the fluid inlet port 906 can include a pipe barb including one or more raised ridges 916a. The diameter of the raised ridges 916a can increase toward the valve body 910. This can facilitate assembly of the fluid inlet pipe 490 with the fluid inlet port 906 while preventing the fluid inlet pipe 490 from being accidentally removed from the fluid inlet port 906.

[0148] The fluid outlet port 990 can extend from the second end 904. As desired, the fluid outlet port 990 can be configured to be fluidically coupled to a fluid outlet tube (not explicitly shown) (e.g., disposed above or within the effluent inlet port 908) and extend therefrom. The fluid outlet tube can then be fluidically coupled to a second waste collection bag (not explicitly shown). The second waste collection bag can be separated from the waste collection bag 28 described herein and provided as a supplement thereto. In some cases, the fluid outlet tube can be threadedly connected to the fluid outlet port 990. In some embodiments, the fluid outlet port 990 can be removably coupled to the valve body 910 using, for example, a removable threaded bonnet 914. Other coupling methods can be used as desired, such as, but not limited to, press fit, snap fit, friction fit, snap ring, etc. In other examples, the fluid outlet port 990 can be formed as a single integral structure with the valve body 910. In some embodiments, the fluid outlet port 990 can include a tube barb including one or more raised ridges 916d. The diameter of the raised ridge 916d can increase toward the valve body 910. This can facilitate assembly of the fluid outlet tube 490 with the fluid outlet port 990 while inhibiting accidental removal of the fluid outlet tube from the fluid outlet port 990. The fluid outlet port 990 can be in fluid communication with the fluid inlet port 906 via the aperture 960, as will be described in greater detail herein.

[0149] The effluent inlet port 908 and the effluent outlet port 912 can extend from the valve body 910, such as extending from the curved sidewall of the valve body 910. Each of the effluent inlet port 908 and the effluent outlet port 912 can be configured to be fluidly coupled to a portion of the effluent waste pipe 68. A first portion of the effluent waste pipe 68 can be fluidly coupled to the effluent inlet port 908 (e.g., disposed above or within the effluent inlet port 908) and extend therefrom as desired. A second portion of the effluent waste pipe 68 can be fluidly coupled to the effluent outlet port 912 (e.g., disposed above or within the effluent outlet port 912) and extend therefrom as desired. The effluent inlet port 908 and the effluent outlet port 912 can be fluidly isolated from the fluid inlet port 906 and the fluid outlet port 990. In some cases, the effluent inlet port 908 and the effluent outlet port 912 may be substantially fluidly isolated from the fluid inlet port 906 and the fluid outlet port 990. For example, when the effluent inlet port 908 and the effluent outlet port 912 are substantially fluidly isolated from the fluid inlet port 906 and the fluid outlet port 990, a small pressure relief fluid path may extend from the fluid inlet port 906 through the spool valve 900 to the effluent inlet port 908 and / or the effluent outlet port 912, which allows pressure in the fluid inlet pipe 490 to be released from the spool valve 900 to close the spool valve 900, however this is not required.

[0150] In some cases, the effluent inlet port 908 and the effluent outlet port 912 can be positioned on opposite sides of the valve body 910, such as about 180 ° from each other. In some cases, the effluent inlet port 908 can extend parallel to the effluent outlet port 912, but axially displaced from the effluent outlet port 812. In some cases, the effluent inlet port 908 and the effluent outlet port 912 can be axially displaced from each other along the longitudinal axis 924 of the valve body 910 so that they do not share a common axis. For example, the effluent inlet port 908 can be positioned closer to the second end 904 of the valve body 910 than the effluent outlet port 912. Alternatively, the effluent inlet port 908 can be positioned closer to the first end 902 of the valve body 910 than the effluent outlet port 912. Other positions and / or configurations of the effluent inlet port 908 and the effluent outlet port 912 can be used as needed. The effluent inlet port 908 can be formed as a single unitary structure with the valve body 910. In other embodiments, the effluent inlet port 908 can be removably coupled to the valve body 910 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc., as desired. Similarly, the effluent outlet port 912 can be formed as a single unitary structure with the valve body 910. In other embodiments, the effluent outlet port 912 can be removably coupled to the valve body 910 using, for example, removable threaded fittings, press fits, snap fits, friction fits, snap rings, etc., as desired. One or both of the effluent inlet port 908 and the effluent outlet port 912 can include one or more raised ridges 916b, 916c. The diameter of the raised ridges 916b, 916c can increase toward the valve body 910. This may facilitate assembly of the effluent waste tube 68 with the effluent inlet port 908 and / or the effluent outlet port 912 while preventing accidental removal of the effluent waste tube 68 from the effluent inlet port 908 and / or the effluent outlet port 912 .

[0151] As described above, the spool valve 900 can be positioned in line with the effluent waste tube 68. For example, the effluent inlet port 908 can be positioned downstream of the connection manifold assembly 62, and the effluent outlet port 912 can be positioned upstream of the effluent collection bag 28. For example, effluent can flow from the thrombectomy catheter 58 through the effluent return tube 66, through the connection manifold assembly 62, and into the effluent waste tube 68. Once in the effluent waste tube 68, the effluent can pass through the spool valve 900 before entering the effluent collection bag 28.

[0152] Additional references Fig.24 , which is a cross-sectional view of the spool valve 900 in a first or closed configuration, and reference Fig.25, which is a cross-sectional view of the spool valve 900 in a second or open configuration, the effluent inlet port 908 can define a cavity 918 extending from a first end 920 outside the valve body 910 to a second end 922 disposed inside the valve body 910. The cavity 918 of the effluent inlet port 908 can extend through the sidewall of the valve body 910 in a direction generally orthogonal to the longitudinal axis 924 of the spool valve 900 to define an opening from the exterior of the valve body 910 to an interior chamber or cavity 926 of the valve body 910. The cavity 918 of the effluent inlet port 908 can be in selective fluid communication with the cavity 926 of the valve body 910. Similarly, the effluent outlet port 912 can define a cavity 928 extending from a first end 930 outside the valve body 910 to a second end 932 disposed inside the valve body 910. The cavity 928 of the effluent outlet port 912 may extend through the sidewall of the valve body 910 in a direction generally orthogonal to the longitudinal axis 924 of the spool valve 900 to define an opening from the exterior of the valve body 910 to an interior chamber or cavity 926 of the valve body 910 .

[0153] A generally cylindrical valve core or piston 934 may be slidably disposed within the interior cavity 926 of the valve body 910. The valve core 934 may be actuated along or in line with the longitudinal axis 924 of the spool valve 900. In the first or closed configuration ( Fig.24 ), the valve core 934 can be positioned to block or close the cavity 918 of the effluent inlet port 908. This can prevent the effluent from entering the cavity 926 of the valve body 910. In the second or open configuration ( Fig.25 ), the valve core 934 can be displaced along the longitudinal axis 924 to align the fluid path through the valve core 934 with the cavity 918 to fluidly connect the cavity 918 of the effluent inlet port 908 with the cavity 928 of the effluent outlet port 912.

[0154] The diameter of the valve core 934 can vary over its length. For example, the valve core 934 can include a middle region 954 or annular groove having a first outer diameter, longitudinally spaced raised regions 948a, 948b (collectively 948) adjacent to the first end 946 of the valve core 934, and longitudinally spaced raised regions 952a, 952b (collectively 952) adjacent to the second end 950 of the valve core 934. Each of the middle region 954 and the raised regions 948, 952 can extend around the circumference of the valve core 934. The raised regions 948, 952 can have an outer diameter that is greater than the first outer diameter of the middle region 954. In some examples, the raised regions 948, 952 can have an outer diameter that is substantially the same as the inner diameter of the inner cavity 926 so as to form a fluid-tight seal at the cavity 918 of the effluent inlet port 908 when the valve core 934 is in the closed configuration. However, in other embodiments, the raised areas 948, 952 may have an outer diameter that is smaller than the inner diameter of the lumen 926. In some embodiments, the valve core 934 may be formed of a resilient material, such as but not limited to rubber, silicone, etc., to allow portions of the valve core 934 to contact the inner surface of the valve body 910 and create a fluid-tight seal.

[0155] The valve core 934 may include a plurality of O-rings or other sealing members 940a, 940b, 940c (collectively 940) positioned at intervals along the length of the valve core 934. The O-ring 940 may be positioned between an outer surface 942 of the valve core 934 and an inner surface 944 of the valve body 910 to provide a fluid-tight seal between the valve core 934 and the valve body 910. The first O-ring 940a may be positioned adjacent to the first end 946 of the valve core 934. The first O-ring 940a may be positioned within a recess defined by a pair of raised areas 948a, 948b. The first O-ring 940a may be configured to substantially fluidically isolate the fluid inlet port 906 from the effluent inlet port 908 and the effluent outlet port 912. The second O-ring 940b and the third O-ring 940c may be positioned adjacent to the second end 950 of the valve core 934. The second and third O-rings 940b, 940c can be positioned within the recess defined by the plurality of raised areas 952a, 952b, 952c. Fig.24 ), the second and third O-rings 940b, 940c may be positioned on the first and second sides of the second end 922 of the cavity 918 of the effluent inlet port 908, respectively, such that the cavity 918 of the effluent inlet port 908 is positioned between the second and third O-rings 940b, 940c. The second and third O-rings 940b, 940c may fluidly isolate the cavity 918 of the effluent inlet port 908 from the cavity 926 of the valve body 910 when the valve 900 is in the closed configuration. For example, when the valve 900 is in the closed configuration, the fluid may not leave the cavity 918 of the effluent inlet port 908.

[0156] The intermediate region 954 of the valve core 934 can have an outer diameter that is smaller than the diameter of the raised regions 948, 952, which can be in the second or open configuration ( Fig.25 ) to align with the cavity 918 of the effluent inlet port 908. It should be noted that in the first or closed configuration, the intermediate region 954 of the valve core 934 can be moved to a position offset from the cavity 918 of the effluent inlet port 908 to fluidly isolate the effluent inlet port 908 from the effluent outlet port 912 via the second and third O-rings 940b, 940c. Moving the valve core 934 to align the intermediate region 954 with the cavity 918 of the effluent inlet port 908 can fluidly couple the cavity 918 of the effluent inlet port 908 with the cavity 928 of the effluent outlet port 912. For example, when the fluid passes through the cavity 918 of the effluent inlet port 908, the fluid can enter the cavity 926 of the valve body 910 and the annular space between the outer surface 942 of the valve core 934 and the inner surface 944 of the valve body 910. The cavity 928 of the effluent outlet port 912 can also be in fluid communication with the annular space between the outer surface 942 of the valve core 934 and the inner surface 944 of the valve body 910. Therefore, fluid can flow out of the cavity 926 of the valve body 910 via the cavity 928 of the effluent outlet port 912, as shown at flow path 956.

[0157] It is contemplated that the radially inwardly extending wall 958 of the valve core 934 may extend across the lumen 938 thereof to substantially fluidly isolate the first end 946 of the valve core 934 from the second end of the valve core 950. The aperture 960 may extend through the thickness of the radially inwardly extending wall 958 to allow air and / or fluid to pass through the aperture 960 to prime the spool valve 900. However, the aperture 960 may be sized to exclude the flow of liquid fluid therethrough. Alternatively or additionally, the aperture 960 may include a hydrophobic membrane disposed across its opening. The hydrophobic membrane may allow air to pass through the aperture 960 while excluding the flow of water or saline therethrough.

[0158] Alternatively, the hole 960 can be sized or configured as a leakage path to allow a small amount of fluid received at the fluid inlet port 906 to enter the inner cavity 938 of the valve core 934 and reach the cavity 992 of the fluid outlet port 990. This can allow pressure to be released when the roller pump 240 is turned off and the valve moves from the open configuration to the closed configuration, as will be described in more detail herein. The radially inwardly extending wall 958 of the valve core 934 can be axially positioned distal to the intermediate region 958 so that fluid leaking through the hole 960 does not enter the effluent flow path 956. For example, the second and third O-rings 940b, 940c can fluidly isolate the effluent flow path 956 from the second end region 984 of the inner cavity 926 of the valve body 910 near the effluent flow path 956.

[0159] For example, the fluid inlet port 906 can define a cavity 976 extending from a first end 978 outside the valve body to a second end 980 disposed inside the valve body 910. The fluid inlet port 906 can extend along or in line with the longitudinal axis 924 of the spool valve 900. The cavity 976 can be in fluid communication with the inner cavity 926 of the valve body 910. The fluid outlet port 990 can define a cavity 992 extending from a first end 994 outside the valve body to a second end 996 disposed inside the valve body 910. The fluid outlet port 990 can extend along or in line with the longitudinal axis 924 of the spool valve 900. The cavity 992 can be in fluid communication with a second end region 984 of the inner cavity 926 of the valve body 910. Fluid can flow through the fluid inlet tube 490 and the lumen 976 of the fluid inlet port 906 into the lumen 926, seep through the hole 960 and exit the second end region 984 of the lumen 926 via the lumen 992 of the fluid outlet port 990, as shown at arrow 986. Fluid exiting the fluid outlet port 990 can travel through the fluid outlet tube to a second collection bag. It is contemplated that providing a second fluid collection bag to collect fluid from a fluid source can allow the device to have a longer operating time. For example, two collection bags can allow the thrombectomy system to operate for a longer period of time by providing a larger volume for effluent and / or fluid.

[0160] A spring 962 or other biasing mechanism may be disposed within the interior cavity 926 of the valve body 910, such as opposite the fluid inlet port 906. The spring 962 may extend from a first end 964 to a second end 966, the first end 472 being configured to be positioned adjacent to and / or in contact with a second end portion 968 of the valve core 934, and the second end 474 being configured to be positioned adjacent to and / or in contact with an inner surface 970 of a bonnet 914 of the spool valve 900. In the absence of an external force, the spring 962 may be configured to bias the valve core 934 toward a first or closed configuration. The bonnet 914 may be releasably coupled to the valve body 910. For example, the bonnet 914 may be configured to threadably engage the valve body 910 via a set of mating threads 972, 974. The bonnet 914 may be provided as a separate component assembled with the valve body 910. Although the bonnet 914 is shown and described as having a threaded coupling 972, 974 with the valve body 910, the bonnet 914 may be secured to the valve body 910 using any desired means, such as, but not limited to, adhesives, friction fits, mechanical engagements, welding, soldering, brazing, threaded engagements, etc. The bonnet 914 may have an outer diameter similar to the outer diameter of the first end region of the valve body 910. The bonnet 914 may include an internal threaded engagement 972 configured to engage an external threaded engagement 974 formed on an outer surface of the valve body 910. In other embodiments, at least one of the fluid inlet port 906, the effluent inlet port 908, and / or the effluent outlet port 912 may be formed as a separate component or coupled to a separate component that is subsequently assembled with the valve body 910 in a manner similar to the bonnet 914.

[0161] The valve core 934 can be actuated to Fig.25 906. The fluid can flow through the fluid inlet port 906 through the fluid inlet tube 490 into the cavity 976 of the fluid inlet port 906 and into the inner cavity 926. Once sufficient fluid pressure builds up within the inner cavity 926 against the first side of the radially inwardly extending wall 958 of the valve core 934, the fluid can push the valve core 934 toward the second end 904 of the spool valve 900 and compress the spring 962 to move the valve core 934 from the first closed configuration ( Fig.24 ) moves to the second opening pattern ( Fig.25900 ). For example, the sufficient fluid pressure can be the amount of pressure required to overcome the biasing force of the spring 962. When the valve core 934 is actuated toward the second end 904, the second end 950 of the valve core 934 can contact the annular wall 982 of the bonnet 914 to provide a mechanical stop that is spaced apart to align the intermediate region 954 with the cavity 918 of the effluent inlet port 908. The cavity 991 of the fluid outlet port 990 can extend through the bonnet 914 and allow air to escape from the inner cavity 926 when the valve core 934 moves toward the second end 904 of the spool valve 900. In addition, the cavity 992 of the fluid outlet port 990 can allow air to enter the inner cavity 926 when the valve core 934 moves toward the first end 902 of the spool valve 900.

[0162] The sliding valve 900 can be configured to open (e.g., actuate the valve core 934) substantially synchronously when the thrombectomy catheter 58 is used. For example, when the clinician activates the drive unit 12 (e.g., operates a foot switch (not explicitly shown) on the drive unit 12), both the pump 56 and the roller pump 240 are activated. In some cases, when the clinician activates the drive unit 12, the pump 56 can be automatically activated simultaneously or successively with the roller pump 240. Because a portion 494 of the fluid inlet tube 490 is disposed within the roller pump 240, actuation of the roller pump 240 drives the fluid through the fluid inlet tube 490 and into the inner cavity 926 of the valve body 910 via the fluid inlet port 906. As described above, the fluid can be saline, ambient air, or other fluid. The fluid pushes the valve core 934 to an open configuration ( Fig.25 ) and allows free flow of effluent through the effluent waste tube 68, along the flow path 956 from the effluent inlet port 908 to the effluent outlet port 912, through the slide valve 900, and into the effluent collection bag 28. For example, the flow of effluent is not limited by the speed of the roller pump 240. Instead, the effluent can flow freely at a rate that achieves fluid flow balance within the system. Since there is no fluid outlet near the first end 946 of the valve core 934, fluid flow may cause the roller pump 240 to stop, and no additional fluid will be delivered to the inner cavity 926 of the slide valve 900, thereby maintaining the valve core 934 in the open position. When the clinician deactivates the drive unit 12 (e.g., releases the foot switch) to stop the operation of the thrombectomy catheter 58, the pump 56 and the roller pump 240 are deactivated, thereby stopping the inflow of fluid to the thrombectomy catheter 58. Since roller pump 240 is not a perfect pump, pressure may release from lumen 926 and spring 962 may again bias valve element 934 toward first end 902 and the closed configuration to stop the flow of effluent through valve 900 to effluent waste bag 28 .

[0163] It is also contemplated that the hole 960 in the radially inwardly extending wall 958 can be configured to define a leak path to allow a small amount of fluid to pass from the first side of the radially inwardly extending wall 958 and enter the second end region 984 of the inner cavity 926 of the valve body 910 after the roller pump 240 is deactivated to release pressure from the inner cavity 926, thereby fluidly connecting the fluid inlet port 906 with the fluid outlet port 990. The hole 960 can be sized so that when the roller pump 240 is running, a pressure differential can be maintained on the valve core 934 to actuate the valve core 934 to the open position, and when the roller pump 240 is stopped, the fluid in the cavity 938 is discharged to release pressure and thus close the valve 900 (i.e., allow the valve core 934 to move to the closed position). For example, the diameter of the hole 960 can be in the range of about 0.1 mm to about 0.2 mm. It is also contemplated that the sliding valve 900 can include any of the pressure relief features or structures described herein.

[0164] Materials that can be used for various components of thrombectomy catheters, slide valves, pump / catheter assemblies, and / or other devices disclosed herein can include those commonly associated with medical devices. For simplicity, the following discussion refers to pump / catheter assemblies and their associated components. However, this is not intended to limit the devices and methods described herein, as the discussion can be applied to other similar devices, tubular members, and / or components of tubular members or devices disclosed herein.

[0165] Various components of the devices / systems disclosed herein may include metals, metal alloys, polymers (some examples of which are disclosed herein), metal-polymer composites, ceramics, combinations thereof, etc., or other suitable materials. Some examples of suitable metals and metal alloys include stainless steels, such as 304V, 304L, and 316LV stainless steels; low carbon steels; nickel-titanium alloys, such as linear elastic and / or superelastic nitinol; other nickel alloys, such as nickel-chromium-molybdenum alloys (e.g., UNS: N06625, such as 625, UNS:N06022, such as UNS:N10276, such as other alloys, etc.), nickel-copper alloys (e.g., UNS: N04400, such as 400, 400, 400, etc.), nickel-cobalt-chromium-molybdenum alloys (e.g., UNS: R30035, such as MP35- etc.), nickel-molybdenum alloys (e.g., UNS: N10665, such as ALLOY ), other nickel-chromium alloys, other nickel-molybdenum alloys, other nickel-cobalt alloys, other nickel-iron alloys, other nickel-copper alloys, other nickel-tungsten or tungsten alloys, etc.; cobalt-chromium alloys; cobalt-chromium-molybdenum alloys (e.g., UNS: R30003, such as etc.); platinum-rich stainless steel; titanium; combinations thereof; etc.; or any other suitable material.

[0166] Some examples of suitable polymers may include polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), polyoxyethylene (POM, e.g., commercially available from DuPont ), polyether block esters, polyurethanes (e.g., polyurethane 85A), polypropylene (PP), polyvinyl chloride (PVC), polyether esters (e.g., commercially available from DSM Engineering Plastics ), ether- or ester-based copolymers (e.g., butylene phthalate / poly(alkylene ether) and / or other polyester elastomers, such as those commercially available from DuPont ), polyamide (for example, commercially available from Bayer or commercially available from Elf Atochem ), elastomeric polyamides, block polyamide / ether, polyether block amide (PEBA, for example, available under the trade name Commercially available), ethylene-vinyl acetate copolymer (EVA), silicone resin, polyethylene (PE), High density polyethylene, Low-density polyethylene, linear low-density polyethylene (e.g. ), polyester, polybutylene terephthalate (PBT), polyethylene terephthalate (PET), polytrimethylene terephthalate, polyethylene naphthalate (PEN), polyetheretherketone (PEEK), polyimide (PI), polyetherimide (PEI), polyphenylene sulfide (PPS), polyphenylene oxide (PPO), poly(p-phenylene terephthalamide) (e.g., ), polysulfone, nylon, nylon-12 (such as commercially available from EMS American Grilon ), perfluoro(propyl vinyl ether) (PFA), ethylene-vinyl alcohol, polyolefins, polystyrene, epoxy resins, polyvinylidene chloride (PVdC), poly(styrene-b-isobutylene-b-styrene) (e.g., SIBS and / or SIBS A), polycarbonate, ionomers, biocompatible polymers, other suitable materials or mixtures, combinations, copolymers, polymer / metal composites, etc. In some embodiments, the sheath can be mixed with a liquid crystal polymer (LCP). For example, the mixture can contain up to about 6 percent LCP.

[0167] In at least some embodiments, part or all of the pump / catheter assembly and its related components may also be doped with, made of, or otherwise include radiopaque materials. Radiopaque materials should be understood as materials that are capable of producing a relatively bright image on a fluorescent screen or with another imaging technique during a medical procedure. This relatively bright image helps users of the pump / catheter assembly and its related components determine their location. Some examples of radiopaque materials may include, but are not limited to, gold, platinum, palladium, tantalum, tungsten alloys, polymer materials loaded with radiopaque fillers, and the like. Additionally, other radiopaque marker bands and / or coils may also be incorporated into the design of the pump / catheter assembly and its related components to achieve the same results.

[0168] It should be understood that the present invention is in many respects merely illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of steps, without exceeding the scope of the present invention. To the extent appropriate, this may include using any of the features of an example embodiment used in other embodiments. Of course, the scope of the present invention is defined by the language of the appended claims.

Claims

1. A thrombectomy catheter and pump assembly, the assembly comprising: thrombectomy catheter; Pumps; a connection manifold assembly positioned between the thrombectomy catheter and the pump; an effluent return tube fluidly coupled to the thrombectomy catheter and the connection manifold assembly; Effluent collection bag; an effluent waste tube fluidly coupled to the connection manifold assembly and the effluent collection bag; as well as A valve is positioned in series with the effluent waste pipe.

2. The assembly of claim 1, wherein the valve is configured to selectively allow effluent to flow from the thrombectomy catheter to the effluent collection bag during use of the thrombectomy catheter.

3. The assembly according to any one of claims 1 to 2, wherein the valve is a spool valve comprising a valve body defining an inner cavity and a valve core movably disposed within the inner cavity.

4. The assembly of claim 3, wherein the valve core further comprises an annular groove extending around a circumference of the valve core, the annular groove being positioned between the first end of the valve core and the second end of the valve core.

5. An assembly according to claim 3 or 4, wherein the sliding valve includes an effluent inlet port, which is fluidly connected to the effluent waste pipe downstream of the connecting manifold assembly; and an effluent outlet port, which is fluidly connected to the effluent waste pipe upstream of the effluent collection bag.

6. The assembly of claim 5, wherein the effluent inlet port and the effluent outlet port are positioned on opposite sides of the valve body, or extend at substantially orthogonal angles to each other.

7. The assembly of claim 5, wherein the spool valve includes a fluid inlet port and an aperture extending through a wall of the valve core such that the fluid inlet port communicates with the effluent outlet port or the fluid outlet port.

8. An assembly according to any one of claims 5 to 7, further comprising a first O-ring and a second O-ring positioned between an outer surface of the valve core and an inner surface of the valve body, wherein when the valve is in a closed configuration, the effluent inlet port is positioned between the first O-ring and the second O-ring.

9. A component according to any one of claims 5 to 8, wherein when the valve is in an open position, the effluent inlet port and the effluent outlet port are in fluid communication with the inner cavity of the valve body, and wherein when the valve is in a closed position, the effluent inlet port and the effluent outlet port are isolated from the inner cavity of the valve body.

10. The assembly of claim 9, wherein when the annular groove of the valve core is aligned with the effluent inlet port and the effluent outlet port, the effluent inlet port and the effluent outlet port are in fluid communication with the inner cavity of the valve body.

11. The assembly of any one of claims 3 to 10, wherein the spool valve comprises a fluid inlet port and a fluid inlet tube extending from a first end fluidly coupled to the fluid inlet port to a second end configured to be fluidly coupled to a fluid source.

12. The assembly of claim 11, wherein the intermediate portion of the fluid inlet tube is configured to be positioned within a roller pump of a thrombectomy catheter system drive unit, wherein fluid flow through the fluid inlet tube is configured to move the valve core from a first closed configuration to a second open configuration; wherein when the valve core is in the second open configuration, effluent flows freely from the thrombectomy catheter to the effluent collection bag; When the valve core is in the first closed configuration, effluent is prevented from flowing from the thrombectomy catheter to the effluent collection bag.

13. A thrombectomy catheter and pump assembly, the assembly comprising: thrombectomy catheter; Pumps; a connection manifold assembly positioned between the thrombectomy catheter and the pump; an effluent return tube fluidly coupled to the thrombectomy catheter and the connection manifold assembly; Effluent collection bag; an effluent waste tube fluidly coupled to the connection manifold assembly and the effluent collection bag; as well as a slide valve positioned in series with the effluent waste pipe, the slide valve comprising: Valve body; an effluent inlet port in fluid communication with the first portion of the effluent waste pipe; an effluent outlet port in fluid communication with a second portion of the effluent waste tube; a fluid inlet port at least substantially fluidly isolated from the effluent inlet port and the effluent outlet port; and A valve core movably disposed in the inner cavity of the valve body; The valve core is configured to move between a closed configuration and an open configuration, wherein the closed configuration is configured to fluidly isolate the effluent inlet port and the effluent outlet port from each other, and the open configuration is configured to fluidly connect the effluent inlet port and the effluent outlet port.

14. The assembly of claim 12, wherein flow of fluid into the fluid inlet port during operation of the thrombectomy catheter is configured to move the valve element from the closed configuration to the open configuration.

15. The assembly of claim 12, wherein when the valve element is in the open configuration, effluent flows freely from the thrombectomy catheter to the effluent collection bag.

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