Kidney-tonifying and immunity-improving composition functional formula

Abstract

The invention discloses a composition formula for tonifying the kidney and improving the immunity of a human body, and relates to a health food formula. The composition formula comprises the following components: 0.45 to 0.52 parts of oyster brachii, 0.165 to 0.172 parts of herba epimedii extract, 0.078 to 0.086 parts of maca extract, 0.076 to 0.085 parts of tribulus terrestris extract, 0.03 to 00.035 parts of eurycoma longifolia eurycomanone, 0.0165 to 0.0173 parts of lycopene, 0.0023 to 0.0027 parts of VB2, 0.00235 to 0.0026 parts of VB6 and 0.0115 to 0.012 parts of zinc. Meanwhile, arginine (0.0825 to 0.087) and selenium (0.000015 to 0.000017), which are used for improving the immunity of a human body, are added. According to the composition formula capable of tonifying the kidney and improving the immunity of the human body, the oyster humeral epimedium herb extract, the maca extract, the tribulus terrestris extract, the eurycoma longifolia eurycomanone, the lycopene, the VB2, the VB6, the zinc, the arginine and the selenium which are used for tonifying the kidney and improving the immunity cooperate with one another and are physically and uniformly mixed and stirred, and the composition is reasonable in proportion, free of toxic and side effects, free of toxic and side effects, free of toxic and side effects and free of side effects. Various components are matched with one another, so that no toxic or side effect exists, and a very good auxiliary effect on tonifying the kidney of a human body and enhancing the immunity of the human body is achieved. The raw materials of the formula are convenient to purchase, high in production benefit and beneficial to wide application.

Description

Technical Field

[0001] The invention relates to a functional formula of a kidney-tonifying and immunity-enhancing composition, and in particular to the field of health-care foods for tonifying the kidney and improving immunity. Background Art

[0002] The continuous increase in basic age, or improper sexual behavior in youth, will cause the body's functional erection to decline continuously. At the same time, there will be a corresponding decline in renal function. When the body's renal function capacity declines, functional disorders of the body will occur, such as the common kidney deficiency that leads to inability to do one's best and mental depression.

[0003] Especially with age, the incidence of male sexual dysfunction is gradually increasing, including erectile dysfunction, loss of libido and ejaculation disorders. Abnormal penile erection may be caused by blood stasis in the erectile tissue (corpora cavernosa) of the penis due to abnormal blood vessels and nerves. Other possible causes include hormone disorders, abnormal penis structure, use of certain drugs and psychological problems. The most common cause is the impact caused by declining kidney function. Summary of the invention

[0004] The purpose of the present invention is to provide a functional formula of a kidney-tonifying and immunity-enhancing composition. The kidney-tonifying and immunity-enhancing composition is mainly prepared by fully mixing and stirring oyster husk, epimedium extract, maca extract, tribulus terrestris extract, eurycoma longifolia, lycopene, VB2, VB6, and zinc, and supplemented with arginine and a small amount of selenium. The mixture is fully stirred and evenly mixed in a stirring pot. Without affecting the kidney-tonifying function, the composition can also assist in strengthening the human body's immunity.

[0005] The composition of the present invention and the raw materials used are not particularly specified and can all be obtained through conventional market purchase channels: among them, oyster brachii was purchased from Shenzhen Lefu Biotechnology Co., Ltd., corresponding to the brand Leyu Shengfu; epimedium extract was purchased from Tianmen Tianbao Chemical Technology Co., Ltd., corresponding to the brand Tianhua brand; maca extract was purchased from Jiangsu Jiujia Biotechnology Co., Ltd., corresponding to the brand Weiran Fengkang; tribulus terrestris extract was purchased from Shandong Pingju Biotechnology Co., Ltd., corresponding to the brand Pingzhiju; tongkat ali kuanteng ketone was purchased from Hubei Changao Pharmaceutical Co., Ltd., corresponding to the brand Changao Pharmaceutical CHANGAO PHARMA; lycopene was purchased from Zhengzhou Kaizhiyu Food Additive Co., Ltd., corresponding to the brand Yuedaoji; VB2 was purchased from Xi'an Lavia Biotechnology Co., Ltd., corresponding to the brand Qinweiya; VB6 was purchased from Shanghai Yuansen Pharmaceutical Raw Materials Co., Ltd., corresponding to the brand Yuansheng; zinc was purchased from Shijiazhuang Shengpeng Chemical Co., Ltd., corresponding to the brand Xinshengpeng; arginine was purchased from Xi'an Lavia Biotechnology Co., Ltd., corresponding to the brand Qinweiya; selenium was purchased from Shenzhen Lefu Biotechnology Co., Ltd., corresponding to the brand Leyu Shengfu.

[0006] To achieve the above-mentioned purpose, the present invention provides a functional formula of a composition for tonifying kidney and improving immunity, comprising the following components of the embodiments: oyster humus, epimedium extract, maca extract, tribulus terrestris extract, eurycoma longifolia, lycopene, VB2, VB6, zinc, arginine, and selenium. The corresponding proportions of the embodiments are (0.45-0.52): (0.165-0.172): (0.078-0.086): (0.076-0.085):

[0007] (0.03-0.035):(0.0165-0.0173):(0.0023-0.0027):(0.00235-0.0026):(0.0115-0.012):(0.0825-0.087):(0.000015-0.000017).

[0008] At the same time, the following weight ratio groups were used: oyster brach (0.3-0.53), epimedium extract (0.137-0.175), maca extract (0.065-0.085), tribulus terrestris extract (0.065-0.086), eurycoma longifolia ketone (0.02-0.037), lycopene (0.0155-0.0182), VB2 (0.0018-0.003), VB6 (0.002-0.0028), zinc (0.01-0.013), arginine (0.078-0.09), and selenium (0.00001-0.000019), wherein the corresponding molecular weights of arginine and selenium are <10,000 Daltons.

[0009] The experimental example methods of the oyster brachii and other compositions are as follows:

[0010] 1. Oyster brachii and epimedium extract were mixed in a mass ratio of 0.35:0.137, and maca extract (0.065), tribulus terrestris extract (0.065), eurycoma longifolia ketone (0.02), lycopene (0.0155), VB2 (0.0018), VB6 (0.002), zinc (0.01), arginine (0.078), and selenium (0.00001) were fully mixed and stirred in a stirring pot to make equal amounts of granules. The granules were easily soluble in water, and then a certain safety value solution was taken for biological administration detection. The corresponding P value obtained by fluorescence intensity reaction was <0.05 through relevant reagents and instruments, stereo fluorescence microscope (SZX7, Olympus, Japan), biological microscope, acetylphenol, dexamethasone, and fluorescence intensity reaction. At the same time, the probability of renal edema in the sample was observed to be <10%.

[0011] 2. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.37:0.139, and are supplemented with maca extract (0.065), tribulus terrestris extract (0.07), eurycoma longifolia ketone (0.02), lycopene (0.0158), VB2 (0.0019), VB6 (0.0021), zinc (0.012), arginine (0.08), and selenium (0.000012) and are fully mixed and stirred in a stirring pot to make equal amounts of particles, which are dissolved in water and a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction, and the P value obtained is <0.05, and the probability of renal edema is <10%.

[0012] 3. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.4:0.14, and are supplemented with maca extract (0.07), tribulus terrestris extract (0.07), eurycoma longifolia ketone (0.025), lycopene (0.016), VB2 (0.002), VB6 (0.0025), zinc (0.01), arginine (0.085), and selenium (0.00001) and are fully mixed and stirred in a stirring pot to make equal amounts of granules, which are dissolved in water and a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction, and the P value obtained is <0.04, and the probability of renal edema is <10%.

[0013] 4. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.45:0.165, and are supplemented with maca extract (0.078), tribulus terrestris extract (0.076), eurycoma longifolia ketone (0.03), lycopene (0.0165), VB2 (0.0023), VB6 (0.00235), zinc (0.0115), arginine (0.0825), and selenium (0.000015) and are fully mixed and stirred in a stirring pot to make equal amounts of particles, which are dissolved in water and a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction, and the P value obtained is <0.02, and the probability of renal edema is 0%.

[0014] 5. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.49:0.168, and are supplemented with maca extract (0.085), tribulus terrestris extract (0.084), eurycoma longifolia ketone (0.032), lycopene (0.167), VB2 (0.0025), VB6 (0.0024), zinc (0.0117), arginine (0.084), and selenium (0.000015) and are fully mixed and stirred in a stirring pot to make equal amounts of granules, which are dissolved in water and a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction, and the P value obtained is <0.01, and the probability of renal edema is 0%.

[0015] 6. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.52:0.172, and are supplemented with maca extract (0.086), tribulus terrestris extract (0.085), eurycoma longifolia ketone (0.035), lycopene (0.0173), VB2 (0.0027), VB6 (0.0026), zinc (0.012), arginine (0.087), and selenium (0.000017) and are fully mixed and stirred in a stirring pot to make equal amounts of granules, which are dissolved in water and a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction, and the P value obtained is <0.02, and the probability of renal edema is 0%.

[0016] 7. Furthermore, the oyster brachium and epimedium extract are mixed in a mass ratio of 0.53:0.175, and are supplemented with maca extract (0.085), tribulus terrestris extract (0.086), eurycoma longifolia ketone (0.037), lycopene (0.0182), VB2 (0.003), VB6 (0.0028), zinc (0.013), arginine (0.09), and selenium (0.000019) and are fully mixed and stirred in a stirring pot to make equal amounts of particles. After the particles are dissolved in water, a certain safety value is taken for biological administration detection. The experiment is repeated by using the fluorescence intensity reaction. The P value obtained is <0.04, and the probability of renal edema is <10%.

[0017] 8. The functional formula of the kidney-tonifying and immunity-enhancing composition, in terms of the proportion of ingredients, oyster humus, epimedium extract, maca extract, tribulus terrestris extract, eurycoma longifolia, lycopene, VB2, VB6, zinc, arginine, and selenium in the following ranges can achieve the best effect of protecting kidney function and enhancing male sexual function. At the same time, the arginine and selenium in the composition help to enhance the body's immunity. The best corresponding proportions of the above composition are (0.45-0.52): (0.165-0.172): (0.078-0.086): (0.076-0.085): (0.03-00.035): (0.0165-0.0173): (0.0023-0.0027):

[0018] (0.00235-0.0026):(0.0115-0.012):(0.0825-0.087):

[0019] (0.000015-0.000017).

[0020] Appendix Description

[0021] Table 1: The corresponding P values ​​of the fluorescence intensity responses of each ratio formula of anti-aging functional particles were all less than 0.05.

[0022] Table 2: The probability of renal edema caused by renal protection test of anti-aging functional particles at the maximum safe value of 1000 μg / mL in each group, the results were all less than 10%. Specific implementation plan

[0023] 1. The specific implementation plan selected zebrafish as the experimental subject. The zebrafish were selected from adult fish that were specially raised and bred according to the experimental standards by the company, and were raised in a simulated wild environment. In order to make the experiment more significant, the experimental zebrafish were specially selected from adult fish that were fertilized for three days for the experiment.

[0024] 2. The experimental subject zebrafish was divided into seven groups during the experiment, with 30 zebrafish in each group. The experimental principle is that the kidney is an important organ of the human body, playing an important role in filtering metabolites from the blood and maintaining normal acid-base and osmotic pressure balance in the body. There are many similarities between the development of zebrafish kidneys and the occurrence and development of diseases in mammalian kidneys, and many genes involved are highly conservative. Therefore, zebrafish are suitable for evaluating the efficacy of protecting kidneys. Paracetylphenol mainly damages renal tubular epithelial cells, leading to renal interstitial fibrosis and renal atrophy, and low-molecular proteinuria and severe anemia symptoms, which is called "paracetylphenol nephropathy". Paracetylphenol can induce renal edema and abnormal renal morphology and function in both humans and zebrafish, causing irreversible renal damage and death. Since zebrafish are transparent throughout, renal edema can be clearly observed. The renal protection and the efficacy of increasing male sexual function are evaluated by the renal edema reduction rate.

[0025] 3. The experimental zebrafish were divided into seven groups, each of which was further divided into three experimental groups, each of which was named a model control group, a positive control group, and a sample treatment group. Among the three experimental groups, the model control group took in an equal amount of acetylphenol (acetylphenol was dissolved and poured into the water for fish farming and taken into the zebrafish), and the positive control group and the sample treatment group took in dexamethasone and samples while taking acetylphenol. After taking the renal protective agent for a period of time, the incidence of renal edema in zebrafish was counted.

[0026] 4. In the embodiment 3, acetylphenol can induce renal edema and abnormal kidney morphology and function in humans and zebrafish, causing irreversible kidney damage and even death, so as to observe whether the zebrafish tested organism can reduce or avoid the incidence of renal edema.

[0027] 5. Data analysis and processing:

[0028] The data analysis was mainly performed using SPSS26 software, and GraphPad Prism8 was used for drawing. The data statistics were expressed as mean ± standard deviation. The experimental results were tested for normal distribution using SPSS software. If the data conformed to the normal distribution, the T parameter test or analysis of variance (ANOVA) was used for significance. If it did not conform to the normal distribution, a non-parametric test was used.

[0029] 6. The corresponding numerical comparison results produced by the experiment show that the renal edema in the sample treatment group was significantly reduced or absent when compared with the positive control group, indicating that the test samples in the sample treatment group have obvious renal protective function.

[0030] Specific implementation content comparison:

[0031] 1. In the experiment, the sample group with the maximum safety value of 1000 μg / mL concentration was used as the positive control group. The experimental controls of each group are as follows:

[0032] 2. The test results show that the functional formula of the kidney-tonifying and immunity-enhancing composition disclosed in the present invention has good results in experimental serial numbers 1-7 and test results 4-6. It can be seen that through the above experimental cases, the kidney-tonifying and immunity-enhancing composition disclosed in the present invention corresponds to oyster brachii (0.45-0.52), epimedium extract (0.165-0.172), maca extract (0.078-0.086), and tribulus terrestris extract ( The composition range proportion embodiment has the best effect.

[0033] 3. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solution of the present invention may be modified in proportion or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

[0034] Table 1:

[0035]

[0036] Table 2:

[0037] Test items Detection concentration (μg / mL) Renal edema rate Renal protection test 1 1000 10％ Renal Protection Test 2 1000 10％ Renal protection test 3 1000 10％ Renal protection test 4 1000 0％ Renal protection test 5 1000 0％ Renal protection test 6 1000 0％ Renal protection test7 1000 10％

Claims

1. A composition formula for tonifying the kidney and improving human immunity, wherein the main ingredients of the composition formula for tonifying the kidney and improving immunity are: oyster humerus, epimedium extract, maca extract, tribulus terrestris extract, eucomycin, lycopene, VB2, VB6, zinc, arginine, and selenium, which work together and are evenly stirred by physical mixing to form a composition in relative proportions. In the formula of the composition for tonifying the kidney and improving human immunity, the corresponding proportions of oyster shell, epimedium extract, maca extract, tribulus terrestris extract, eucomycin, lycopene, VB2, VB6, zinc, arginine and selenium are (0.45-0.52): (0.165-0.172): (0.078-0.086): (0.076-0.085)：(0.03-00.035)：(0.0165-0.0173)：(0.0023-0.0027)： (0.00235-0.0026)：(0.0115-0.012)：(0.0825-0.087)： (0.000015-0.000017); the combined components are uniformly mixed physically to obtain the corresponding composite material.

2. According to the composition formula for invigorating the kidney and improving human immunity, the characteristics are Selenium, the molecular weight content of this component <10000Da.

3. The composition for tonifying the kidney and improving human immunity according to claim 1, characterized in that The composition comprises 3 to 6 kinds of any one or more kinds of compositions for nourishing the kidney and improving human immunity.

4. The composition for tonifying the kidney and improving human immunity according to claim 1, characterized in that: The kidney-tonifying composition accounts for 80%-90% of the total ingredients.

5. The composition for tonifying the kidney and improving human immunity according to claim 1, characterized in that: The functional granule composition of the kidney-tonifying and human immunity-enhancing composition is easily soluble in water and easily absorbed by the human body.

6. According to the formula of the composition for tonifying the kidney and improving human immunity, the arginine and a small amount of selenium mentioned above have the effect of improving human immunity and preventing colds.

7. According to the formula of the kidney-tonifying and human immunity-enhancing composition of claim 1, a certain dose of the composition is mixed and formulated into particles containing a corresponding amount, and the composition can also be made into corresponding tablets, capsules, granules, pills or oral liquids.

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