Nasal-soothing lung-moistening health-care oil and preparation method thereof

Abstract

According to the nasal soothing and lung moistening health-care oil and the preparation method thereof, fractionated coconut oil and jojoba oil form a nano-carrier, 10 active components such as flos magnoliae oil, angelica dahurica oil and eucalyptus oil are matched, and the nasal soothing and lung moistening health-care oil is prepared through gradient fusion and high-pressure microjet technologies. The product breaks through a one-way action mode of a traditional nasal cavity preparation, synchronously achieves triple effects of opening and closing orifices, inhibiting inflammation and repairing mucous membranes, has a remarkable improvement effect on nasal cavity dryness and lung function decline, and is free of mucous membrane irritation.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compound preparations, and specifically relates to a nasal care external composition based on plant essential oils and a preparation process thereof, which is particularly suitable for improving sub-health conditions related to nasal congestion, dry nose and dry lungs. Background Art

[0002] Allergic rhinitis, chronic sinusitis and nasal sensitivity caused by air pollution are becoming increasingly prominent. Existing nasal preparations mostly contain hormones or vasoconstrictors (such as oxymetazoline), which pose the risk of drug dependence and mucosal damage. Traditional Chinese medicine nasal preparations are mainly single-ingredient drops (such as Xanthium sibiricum oil), which have the problems of slow onset and single effect. The present invention integrates the functions of clearing the orifices, anti-inflammatory and moisturizing through a multi-component synergistic design to achieve integrated conditioning of the nasal cavity and respiratory tract. Summary of the invention Technical issues

[0003] Provided is an external oil preparation with both rapid orifice-opening and long-lasting lung-moistening functions, to solve the technical defects of existing nasal preparations, such as high irritation and insufficient repairing ability. Technical Solution

[0004] 1. Raw material composition (by mass percentage): Basic carrier oil (60-75%): Fractionated coconut oil 30-40% Jojoba oil 20-30% Sweet almond oil 10-20% Active essential oil complex (25-40%): Tongqiao group: magnolia oil 5-8%, angelica oil 3-6%, peppermint oil 4-7% Anti-inflammatory group: Ravensara leaf oil 3-5%, chamomile oil 2-4%, thyme oil 2-4% Lung moistening group: eucalyptus oil 3-5%, lemon oil 2-4% Synergistic group: lavender oil 1-3%, rosemary oil 1-3% 2. Preparation method: a. Base oil pretreatment: Mix fractionated coconut oil, jojoba oil and sweet almond oil and homogenize with ultrasound (35kHz) at 40-50℃ for 20 minutes b. Gradient fusion of active components: Add in batches in the order of orifice-opening group → anti-inflammatory group → lung-moistening group → synergistic group, with an interval of 5 minutes between each batch. c. Nanoemulsification: Use high-pressure microfluidics equipment (15,000 psi) to cycle 3 times to form a stable system with a particle size of ≤100 nm d. Low temperature aging: The mixture is refrigerated at 4°C for 48 hours and then filtered through a 0.1μm sterile filter membrane.

[0005] Beneficial effects 1. Triple action mechanism: limonene in magnolia oil quickly opens the sinus passages, ravensa leaf oil inhibits the release of histamine, and jojoba oil forms a long-lasting moisturizing film 2. Mucosal affinity design: Nanoemulsion particle size distribution (D50=65nm) ensures that the active ingredients penetrate into the cilia roots, and the nasal retention time is extended to 4-6 hours 3. Clinical verification: 90 patients with chronic rhinitis applied the product twice a day to their nasal cavities. After 7 days, the nasal resistance value decreased by 52% and the nasal moisture increased by 83%. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 It is a nasal soothing and lung moistening health oil process flow chart DETAILED DESCRIPTION Example

[0006] Raw material ratio (total mass 1000g): Basic carrier oil: 350g fractionated coconut oil, 250g jojoba oil, 100g sweet almond oil Active essential oil complex: Tongqiao group: magnolia oil 60g, angelica oil 40g, peppermint oil 50g Anti-inflammatory group: Ravensara leaf oil 40g, chamomile oil 30g, thyme oil 30g Lung moistening group: eucalyptus oil 40g, lemon oil 30g Synergistic group: lavender oil 20g, rosemary oil 20g Preparation process: 1. After mixing the base oil, ultrasonically homogenize at 45°C for 20 minutes 2. Add the active ingredients in four batches, with 5 minutes between each batch 3. High-pressure microfluidics treatment 3 times (pressure 15000psi) 4. Refrigerate at 4℃ for 48 hours and aseptically package into roller bottles Effect test In vitro bovine nasal mucosal permeation experiments showed that the main active ingredients (limonene and eucalyptol) permeated up to 82μg / cm² within 30 minutes Human infrared thermal imaging shows that 15 minutes after use, the nasal concha temperature dropped by 2.3°C and the blood flow increased by 41%. The innovation of the present invention is: ① The first three-dimensional action model of "physical opening of the orifices + chemical anti-inflammatory + biological moisturizing" ② Break through the nasal mucosal barrier through high-pressure micro-jet technology (penetration depth reaches the submucosal layer) ③ The combination scheme achieves the synergistic effect of local nasal action and systemic lung conditioning.

Claims

1. A nose soothing and lung moistening health oil, characterized in that It is composed of the following components in percentage by mass: Basic carrier oil 60-75%: Fractionated coconut oil 30-40%, jojoba oil 20-30%, sweet almond oil 10-20% Active essential oil complex 25-40%: Orifice-opening group: magnolia oil 5-8%, angelica oil 3-6%, peppermint oil 4-7% Anti-inflammatory group: Ravensara leaf oil 3-5%, chamomile oil 2-4%, thyme oil 2-4% Lung moistening group: eucalyptus oil 3-5%, lemon oil 2-4% Synergistic group: lavender oil 1-3%, rosemary oil 1-3%.

2. The health care oil according to claim 1, characterized in that The preferred ratio of the active composite essential oil is: 6% magnolia oil, 4% angelica oil, 5% peppermint oil, 4% ravensa leaf oil, 3% chamomile oil, 3% thyme oil, 4% eucalyptus oil, 3% lemon oil, 2% lavender oil, and 2% rosemary oil.

3. A method for preparing the nose soothing and lung moistening health oil according to any one of claims 1 to 2, characterized in that The following steps are involved: a. Ultrasonic homogenization of base carrier oil to form nanoscale mixed matrix b. Add active ingredients in the order of Tongqiao group → anti-inflammatory group → lung moistening group → synergistic group c. High-pressure microfluidic nanoemulsification treatment (pressure 12000-18000psi) d. After low-temperature maturation, sterile filtration and packaging are performed.

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