Anti-allergy soothing composition, toning lotion as well as preparation method and application of anti-allergy soothing composition and toning lotion

Abstract

The invention provides an anti-allergy soothing composition, toning lotion and a preparation method and application thereof, and belongs to the technical field of skin care products. The anti-allergy soothing composition comprises the following components in parts by mass: 20-30 parts of a thin-shell sesame oil camellia extract, 16-22 parts of a witch hazel extract, 10-15 parts of a herba schizonepetae extract and 8-18 parts of a felwort extract, and the anti-allergy soothing composition can promote skin inflammation resistance and repair while soothing, is beneficial to repair of a skin barrier, and has a good anti-allergy effect. The external stimulation resistance of the skin is improved. The toning lotion disclosed by the invention contains the anti-allergy soothing composition, is not added with an emulsifier and a surfactant, has natural components, is mild and non-irritant, is suitable for normal skin and sensitive skin, and can relieve allergic reactions such as skin itch, redness and swelling, inflammation and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and in particular to an anti-allergic soothing composition, a lotion, and a preparation method and application thereof. Background Art

[0002] Sensitive skin refers to a highly reactive state of the skin under physiological or pathological conditions, which may manifest as subjective symptoms such as burning, stinging, itching and tightness, with or without objective signs such as erythema, capillary dilation and desquamation, mainly occurring on the face. Damage to the skin barrier function can lead to water loss and invasion of external irritants, which in turn can cause allergic reactions such as redness, itching and burning, affecting health and appearance.

[0003] The main causes of sensitive skin include the following: 1. Damaged skin barrier and increased transepidermal water loss, resulting in low water content in the stratum corneum. External factors destroy the skin's barrier function, making it easier for external stimuli to enter the skin and cause allergic reactions; 2. High nerve growth content. When stimulated by external stimuli, the nerves are highly reactive and prone to allergic reactions; 3. Inflammatory response. Compared with normal skin, sensitive skin is more difficult to resist the invasion of external irritants and allergens due to the characteristics of barrier function damage or abnormal nerve function. It is prone to a series of skin inflammatory reactions caused by irritation or allergies, which further damages the skin barrier structure and nerve endings, leading to a vicious cycle.

[0004] Traditional anti-allergic soothing products Traditional soothing products have the following defects: 1. They mostly rely on hydration and moisturizing, but cannot repair the barrier or block the release of inflammatory mediators for a long time, and the action time is short. 2. Insufficient stability of ingredients: For example, key ingredients such as ceramide are easy to precipitate due to poor water solubility, affecting product stability and bioavailability. Although the invention patent with publication number CN104173207A discloses a skin barrier repair preparation and its preparation method, by adding composite ceramide and compounding specific oils, the product stability is improved, but its ingredients are complex, including a variety of surfactants and preservatives, and the irritation is strong. After use, it may cause eye irritation or physical friction damage to the stratum corneum, which will further lead to skin sensitivity. 3. The effect of a single ingredient is limited, and there is a lack of multi-target synergistic mechanism, which makes it difficult to comprehensively deal with the complex causes of sensitive skin. Therefore, how to provide an anti-allergic soothing product that can improve the skin barrier function and anti-inflammatory effect has become one of the problems that need to be solved urgently. Summary of the invention

[0005] In view of this, the present invention provides an anti-allergic soothing composition, a lotion, and a preparation method and application thereof, which can repair the barrier in a long-term manner, improve the skin barrier function and anti-inflammatory effect, and soothe and resist allergies.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides an anti-allergic soothing composition, comprising the following components in parts by weight: 20-30 parts of camellia oleifera extract, 16-22 parts of witch hazel extract, 10-15 parts of schizonepeta extract and 8-18 parts of gentian extract.

[0008] The present invention also provides application of the anti-allergic and soothing composition in the preparation of skin care products.

[0009] Preferably, the skin care product includes lotion, spray, emulsion, cream, cleanser, gel or mask.

[0010] Preferably, the mass percentage of the anti-allergic soothing composition in the skin care product is 0.5-10%.

[0011] The invention provides an anti-allergic soothing lotion, comprising the following components in percentage by weight: 10-20% of a water-soluble moisturizer, 0.1-0.5% of a water-soluble thickener, 0.5-10% of the anti-allergic soothing composition, 0.05-0.1% of a solubilizing agent, 0.01-0.2% of a pH regulator, 0.05-0.1% of a chelating agent, and 60-95% of water.

[0012] Preferably, the water-soluble moisturizer includes at least one of glycerin, dipropylene glycol, butylene glycol and hyaluronic acid; the water-soluble thickener includes at least one of xanthan gum, guar gum, sodium alginate, hydroxyethyl cellulose and acrylate / C10-30 alkyl acrylate cross-linked polymer.

[0013] Preferably, the solubilizer includes at least one of pentanediol, hexylene glycol and caprylyl glycol, and the pH adjuster includes at least one of citric acid, lactic acid, tartaric acid, sodium citrate, sodium dihydrogen phosphate and sodium bicarbonate.

[0014] Preferably, the chelating agent is EDTA.

[0015] The present invention also provides a method for preparing the lotion, comprising the following steps:

[0016] S1. Mixing a water-soluble humectant, a water-soluble thickener, a chelating agent and water to obtain a solution 1;

[0017] S2. Mixing solution 1 and the anti-allergic soothing composition and the solubilizer to obtain solution 2;

[0018] S3. Use a pH adjuster to adjust the pH value of solution 2 to 6.0-6.8, stir, let stand and then filter to obtain the anti-allergic soothing lotion.

[0019] Preferably, the standing time is 12 to 24 hours.

[0020] By adopting the above technical scheme, the present invention has the following beneficial effects: the anti-allergic soothing composition of the present invention comprises the following components by mass: 20-30 parts of Camellia oleifera extract, 16-22 parts of Hamamelis virginiana extract, 10-15 parts of Nepeta extract and 8-18 parts of Gentiana extract, and the anti-allergic soothing composition can promote skin anti-inflammatory and repair while soothing, is beneficial to the repair of the skin barrier, and improves the skin's ability to resist external stimuli. The lotion of the present invention contains the anti-allergic soothing composition, does not add emulsifiers and surfactants, has no harmful additives, has mild ingredients and is non-irritating, is suitable for normal skin and sensitive skin, and can relieve allergic reactions such as skin itching, redness, swelling, and inflammation. DETAILED DESCRIPTION

[0021] The invention provides an anti-allergic soothing composition, comprising the following components in parts by weight: 20-30 parts of camellia oleifera extract, 16-22 parts of witch hazel extract, 10-15 parts of schizonepeta extract and 8-18 parts of gentian extract.

[0022] In the anti-allergic soothing composition of the present invention, the mass fraction of the Camellia oleifera extract is 20 to 30 parts, more preferably 22 to 28 parts, and more preferably 25 parts;

[0023] The weight proportion of the witch hazel extract is 16 to 22 parts, more preferably 18 to 20 parts, and more preferably 19 parts;

[0024] The mass fraction of the Nepeta extract is 10 to 15 parts, more preferably 12 to 14 parts, and more preferably 13 parts;

[0025] The mass fraction of the gentian extract is 8 to 18 parts, more preferably 11 to 15 parts, and even more preferably 13 parts.

[0026] The present invention also provides the use of the anti-allergic soothing composition in the preparation of skin care products; the skin care products include lotions, sprays, emulsions, creams, cleansers, gels or masks; the mass percentage of the anti-allergic soothing composition in the skin care products is 0.5-10%, more preferably 2-8%, and more preferably 5%.

[0027] The present invention also provides an anti-allergic soothing lotion, comprising the following components in percentage by weight: 10-20% of a water-soluble moisturizer, 0.1-0.5% of a water-soluble thickener, 0.5-10% of the anti-allergic soothing composition, 0.05-0.1% of a solubilizing agent, 0.01-0.2% of a pH regulator, 0.05-0.1% of a chelating agent, and 60-95% of water;

[0028] The mass percentage of the water-soluble moisturizer is further preferably 12-18%, more preferably 15%;

[0029] The mass percentage of the water-soluble thickener is further preferably 0.2-0.4%, more preferably 0.3%;

[0030] The mass percentage of the anti-allergic soothing composition is further preferably 3-7%, more preferably 5%;

[0031] The mass percentage of the solubilizing agent is further preferably 0.06 to 0.09%, more preferably 0.08%;

[0032] The mass percentage of the pH adjuster is further preferably 0.05 to 0.15%, more preferably 1%;

[0033] The mass percentage of the chelating agent is further preferably 0.06-0.08%, more preferably 0.07%;

[0034] The mass percentage of water is more preferably 60 to 95%, more preferably 70 to 80%, and more preferably 78.55%.

[0035] In the anti-allergic soothing lotion of the present invention, the water-soluble moisturizer includes at least one of glycerin, dipropylene glycol, butylene glycol and hyaluronic acid; the water-soluble thickener includes at least one of xanthan gum, guar gum, sodium alginate, hydroxyethyl cellulose and acrylate / C10-30 alkyl acrylate cross-linked polymer;

[0036] The solubilizer includes at least one of pentylene glycol, hexylene glycol and octyl glycol. In addition to promoting the dissolution of insoluble substances, pentylene glycol, hexylene glycol and octyl glycol are also natural preservatives, which play an antiseptic role and avoid the addition of harmful preservatives.

[0037] The pH adjuster includes at least one of citric acid, lactic acid, tartaric acid, sodium citrate, sodium dihydrogen phosphate, and sodium bicarbonate;

[0038] The chelating agent is EDTA.

[0039] The present invention also provides a method for preparing the anti-allergic soothing lotion, comprising the following steps:

[0040] S1. Mixing a water-soluble humectant, a water-soluble thickener, a chelating agent and water to obtain a solution 1;

[0041] S2. Mixing solution 1 and the anti-allergic soothing composition and the solubilizer to obtain solution 2;

[0042] S3. Use a pH adjuster to adjust the pH value of solution 2 to 6.0-6.8, stir, let stand and then filter to obtain the anti-allergic soothing lotion, the standing time is 12-24 hours, more preferably 16-20 hours, and more preferably 18 hours.

[0043] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the scope of protection of the present invention. The raw materials used in the embodiments of the present invention, unless otherwise specified, were purchased through commercial channels.

[0044] Example 1

[0045] The invention discloses an anti-allergic and soothing composition, which is composed of 20g of camellia oleifera extract, 16g of witch hazel extract, 10g of schizonepeta extract and 8g of gentiana extract.

[0046] An anti-allergic soothing lotion is composed of the following components: 10g of glycerin, 0.1g of hydroxyethyl cellulose, 0.5g of the above anti-allergic soothing composition, 0.05g of 1,2-pentanediol, 0.01g of a pH regulator (citric acid / sodium citrate) and 0.05g of EDTA, and 89.29g of water.

[0047] The preparation method of the anti-allergic soothing lotion comprises: mixing glycerin, hydroxyethyl cellulose, EDTA and water to obtain solution 1; mixing solution 1 with the anti-allergic soothing composition and 1,2-pentanediol to obtain solution 2; adjusting the pH value of solution 2 to 6.0 with citric acid / sodium citrate, stirring, standing for 12 hours and then filtering to obtain the anti-allergic soothing lotion.

[0048] Example 2

[0049] The invention discloses an anti-allergic and soothing composition, which is composed of 25g of camellia oleifera extract, 18g of witch hazel extract, 13g of schizonepeta extract and 12g of gentiana extract.

[0050] An anti-allergic soothing lotion is composed of the following components: 15g of hyaluronic acid, 0.3g of xanthan gum, 5g of the above anti-allergic soothing composition, 0.08g of caprylyl glycol, 0.1g of a pH regulator (tartaric acid / sodium bicarbonate) and 0.07g of EDTA, and 79.45g of water.

[0051] The preparation method of the anti-allergic soothing lotion is as follows: hyaluronic acid, xanthan gum, EDTA and water are mixed to obtain solution 1; solution 1 is mixed with the anti-allergic soothing composition and caprylyl glycol to obtain solution 2; the pH value of solution 2 is adjusted to 6.5 with tartaric acid / sodium bicarbonate, stirred, allowed to stand for 18 hours and then filtered to obtain the anti-allergic soothing lotion.

[0052] Example 3

[0053] An anti-allergic and soothing composition consists of 30g of camellia oleifera extract, 22g of witch hazel extract, 15g of schizonepeta extract and 18g of gentian extract.

[0054] An anti-allergic soothing lotion is composed of the following components: 20 g of dipropylene glycol, 0.5 g of sodium alginate, 10 g of the above anti-allergic soothing composition, 0.1 g of 1,2-hexanediol, 0.2 g of a pH regulator (lactic acid / sodium dihydrogen phosphate) and 0.1 g of EDTA, and 69.1 g of water.

[0055] The preparation method of the anti-allergic soothing lotion is as follows: dipropylene glycol, sodium alginate, EDTA and water are mixed to obtain solution 1; solution 1 is mixed with the anti-allergic soothing composition and 1,2-hexanediol to obtain solution 2; the pH value of solution 2 is adjusted to 6.8 with lactic acid / sodium dihydrogen phosphate, stirred, allowed to stand for 24 hours and then filtered to obtain the anti-allergic soothing lotion.

[0056] Comparative Example 1

[0057] Different from Example 1, the composition and lotion do not contain Camellia oleifera extract.

[0058] Comparative Example 2

[0059] The difference from Example 1 is that in the composition and lotion, the witch hazel extract is replaced by the Centella asiatica extract in equal amounts.

[0060] Comparative Example 3

[0061] The difference from Example 1 is that in the composition and lotion, an equal amount of honeysuckle extract is used to replace the schizonepeta extract.

[0062] Comparative Example 4

[0063] The difference from Example 1 is that in the composition and lotion, the gentian extract is replaced with an equal amount of purslane extract.

[0064] Comparative Example 5

[0065] The difference from Example 1 is that in the composition, the weight of the witch hazel extract is 35 g.

[0066] Comparative Example 6

[0067] The difference from Example 1 is that in the composition, the mass of the Camellia oleifera extract is 10 g.

[0068] Experimental Example 1. Cell experiment

[0069] Referring to the method in Zhang Geke's master's thesis "Screening of Plant-derived Soothing Active Substances and Study of Their Activity" published on June 1, 2022, the soothing and anti-allergic compositions in Examples 1 to 3 and Comparative Examples 1 to 5 were tested for their effects on the secretion inhibition of inflammatory factors and cell viability of RAW264.7 mouse macrophages. The concentration of each composition in the cell culture system was 100 mg / mL, and 0.1 g / L dexamethasone was used as a positive control. The inhibition rates of each composition on RAW264.7 mouse macrophage cell viability, inflammatory factors TNF-α, and IL-6 are shown in Table 1.

[0070] Table 1 Cell viability and inflammatory factor inhibition rate of RAW264.7 mouse macrophages in each group

[0071]

[0072]

[0073] As shown in Table 1, the cell viability of each group is higher than 95%, indicating that the compositions of the embodiments and comparative examples are safe and non-toxic within the concentration. It can be seen from the inhibition rate of inflammatory factors that the anti-inflammatory effect of the composition of the embodiment of the present invention is better than that of the comparative example, indicating that the thin shell fragrant oil camellia extract, witch hazel extract, schizonepeta extract and gentian extract in the composition can synergistically improve the anti-inflammatory effect of the composition. The anti-inflammatory effect of the composition is weakened by deleting or replacing the components in the composition, or changing the mass ratio of the components.

[0074] Experimental Example 2. Skin barrier repair experiment

[0075] The skin barrier function can prevent the invasion of various harmful factors, the loss of various nutrients in the tissue, and the loss of other substances such as water. The TEWL value is Trans Epidermal Water Loss, which is an important indicator to measure the skin barrier function. Several subjects aged 30 to 40 with sensitive skin (thin skin surface, easy to turn red, prone to itching and even red blood streaks after using irritating skin care products) were recruited and randomly divided into 10 groups, 5 male and 5 female subjects, and the subjects applied 2±0.1mL of lotion of each group twice a day, morning and evening, about 10cm from the base of the palm on the inner side of the arm, and patted until absorbed after application. The subjects who applied deionized water were used as controls to test the transepidermal water loss rate just after use, two weeks after use, and four weeks after use. The transepidermal water loss rate of the skin was tested using a transepidermal water loss tester, and the average value was taken, and the change rate after four weeks was calculated, which was the change rate after four weeks = (transepidermal water loss rate after four weeks of use - transepidermal water loss rate just after use) / transepidermal water loss rate just after use * 100%. At the same time, the number of people who developed allergic symptoms (redness, itching or red blood streaks) after applying lotion was counted, and the transepidermal water loss rate and the number of allergic people in each group are shown in Table 2.

[0076] Table 2 Transepidermal water loss rate of subjects in each group

[0077]

[0078]

[0079] As shown in Table 2, after the subjects used the samples made from the composition of the present invention for 4 weeks, the TEWL value of the subjects' skin was significantly reduced, and was better than that of the comparative example and the control group, and there was no allergic reaction, indicating that the lotion of the present invention is mild and soothing, and can significantly improve the skin barrier function.

[0080] Experimental Example 3. Stability Test

[0081] Accelerated test: The lotions of Examples 1 to 3 were stored at 45±5°C, ambient humidity, and away from direct light for 3 months. Compared with the initial sample, the lotions of Examples 1 to 3 showed no leakage, no color change, no stratification, no precipitation, and no crystallization, indicating that the lotions of the present invention have good stability.

[0082] It can be seen from the above examples that the present invention provides an anti-allergic soothing composition, a lotion, and a preparation method and application thereof. The anti-allergic soothing composition of the present invention has an anti-inflammatory effect, and the anti-allergic soothing lotion of the present invention can repair the skin barrier and has good stability.

[0083] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-allergic soothing composition, characterized in that: The invention comprises the following components in parts by weight: 20 to 30 parts of camellia oleifera extract, 16 to 22 parts of witch hazel extract, 10 to 15 parts of schizonepeta extract and 8 to 18 parts of gentiana extract.

2. Use of the anti-allergic soothing composition according to claim 1 in the preparation of skin care products.

3. The use according to claim 2, characterized in that: The skin care products include lotions, sprays, emulsions, creams, cleansers, gels or masks.

4. The use according to claim 2, characterized in that: The mass percentage of the anti-allergic soothing composition in the skin care product is 0.5-10%.

5. An anti-allergic soothing lotion, characterized in that: The invention comprises the following components in percentage by weight: 10-20% of a water-soluble moisturizer, 0.1-0.5% of a water-soluble thickener, 0.5-10% of the anti-allergic soothing composition according to claim 1, 0.05-0.1% of a solubilizing agent, 0.01-0.2% of a pH adjusting agent, 0.05-0.1% of a chelating agent and 60-95% of water.

6. The anti-allergic soothing lotion according to claim 5, characterized in that: The water-soluble moisturizer includes at least one of glycerin, dipropylene glycol, butylene glycol and hyaluronic acid; the water-soluble thickener includes at least one of xanthan gum, guar gum, sodium alginate, hydroxyethyl cellulose and acrylate / C10-30 alkyl acrylate cross-linked polymer.

7. The anti-allergic soothing lotion according to claim 5, characterized in that: The solubilizer includes at least one of pentanediol, hexylene glycol and caprylyl glycol, and the pH adjuster includes at least one of citric acid, lactic acid, tartaric acid, sodium citrate, sodium dihydrogen phosphate and sodium bicarbonate.

8. The anti-allergic soothing lotion according to claim 5, characterized in that: The chelating agent is EDTA.

9. The method for preparing the lotion according to any one of claims 5 to 8, characterized in that: The following steps are involved: S1. Mixing a water-soluble humectant, a water-soluble thickener, a chelating agent and water to obtain a solution 1; S2. Mixing solution 1 with the anti-allergic soothing composition and the solubilizer according to claim 1 to obtain solution 2; S3. Use a pH adjuster to adjust the pH value of solution 2 to 6.0-6.8, stir, let stand and then filter to obtain the anti-allergic soothing lotion.

10. The preparation method according to claim 9, characterized in that: The standing time is 12 to 24 hours.

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