Oral liquid for treating infertility and preparation method thereof

Abstract

The invention relates to the technical field of oral liquids, and particularly discloses an oral liquid for treating infertility and a preparation method thereof, the oral liquid comprises the following raw materials by percentage: 20%-40% of a schisandra propinqua ethyl acetate extract, 20%-40% of a companumoea root polysaccharide extract, 10%-50% of a China rose general flavone extract, 20%-40% of a lycopus lucidus volatile oil extract, auxiliary materials, water and the like. According to the traditional Chinese medicine composition, multiple active ingredients such as the schisandra propinqua ethyl acetate extract, the companumoea root polysaccharide extract and the China rose general flavone extract are fused on the basis of the Chinese herbal medicines, the organism is comprehensively conditioned, the functions of the female reproductive system are comprehensively improved, and the pregnancy probability is increased. The traditional Chinese medicine composition can enrich and activate blood, regulate the environment in the uterus and assist key reproduction links such as follicle development, ovulation and fertilized ovum implantation, and compared with a traditional Chinese medicine decoction, the traditional Chinese medicine composition does not need to be decocted and is convenient to take and easy to carry. A patient can accurately take the medicine on time according to the dosage, the overall treatment effect can be improved, and the medicine use requirement of the infertility patient in the modern fast-paced life is met.

Description

Technical Field

[0001] The invention belongs to the technical field of oral liquids, and in particular relates to an oral liquid for treating infertility and a preparation method thereof. Background Art

[0002] As a global health problem, infertility has brought heavy psychological burdens and life troubles to many families. According to statistics from the World Health Organization, about 15% of couples worldwide are affected by infertility, and this proportion is increasing year by year. In China, with the postponement of childbearing age, the increase of life pressure and the change of environmental factors, the number of infertility patients is also increasing, and the demand for effective treatment methods is extremely urgent.

[0003] At present, the main clinical treatments for infertility are drug therapy, surgical treatment and assisted reproductive technology. Drug treatment often uses hormone drugs to regulate endocrine and promote ovulation, but these drugs have obvious side effects, such as causing multiple pregnancies, ovarian hyperstimulation syndrome, etc., which can pose a threat to the patient's health in severe cases. Surgical treatment is aimed at organic lesions such as fallopian tube obstruction and endometriosis, but the surgery is traumatic and the recovery period is long, and some patients still have difficulty conceiving after surgery. Assisted reproductive technology, such as in vitro fertilization, has an improved success rate, but it is expensive and has strict requirements on the patient's physical condition, which many families cannot afford.

[0004] Traditional Chinese medicine has a long history in the treatment of infertility and has accumulated rich experience. Traditional Chinese medicine has gradually gained favor among patients for its overall conditioning and few side effects. It can fundamentally regulate the body's qi and blood, viscera function, improve the reproductive environment, and increase the chance of conception. However, there are many shortcomings in the existing dosage forms of traditional Chinese medicine for the treatment of infertility. Traditional Chinese medicine decoctions require patients to decoct them by themselves, which is time-consuming and laborious, and has a bitter taste and poor patient compliance. Although solid dosage forms such as pills and powders are easy to carry and take, they are relatively slowly absorbed and have low bioavailability, which affects the treatment effect. Summary of the invention

[0005] The object of the present invention is to provide an oral liquid for treating infertility and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] An oral liquid for treating infertility comprises the following raw materials in percentage: 20%-40% of ethyl acetate extract of Sargentodoxae, 20%-40% of polysaccharide extract of Codonopsis pilosula, 10%-50% of total flavonoids extract of Rosa chinensis, 20%-40% of volatile oil extract of Asparagus cochinchinensis, 5%-15% of flavonoids glycoside extract of Epimedium, 3%-10% of angelica polysaccharide and ferulic acid complex, 3%-8% of wolfberry polysaccharide and carotenoid mixture, 2%-6% of yam amylase inhibitor, 0.1%-0.5% of flavoring agent, 0.05%-0.3% of preservative, and the balance is water.

[0008] Preferably, the raw materials include the following percentages: 32% ethyl acetate extract of Sarcandra cuneae, 28% polysaccharide extract of Codonopsis pilosula, 12% total flavonoids extract of Rosa chinensis, 10% volatile oil extract of Asparagus cochinchinensis, 9% flavonoid glycoside extract of Epimedium, 4.5% complex of Angelica sinensis polysaccharide and ferulic acid, 3% mixture of Lycium barbarum polysaccharide and carotenoid, 3% amylase inhibitor of Chinese yam, 0.3% flavoring agent, 0.2% preservative, and the balance is water.

[0009] A method for preparing an oral liquid for treating infertility comprises the following steps:

[0010] S1. Preparation of extract: Take crude powder of Sansambar formosana, add 8 times amount of ethyl acetate, reflux extraction 3 times, 2 hours each time, combine the extracts, and concentrate under reduced pressure to a relative density of 1.15-1.20 (60°C) to obtain ethyl acetate extract of Sansambar formosana; cut Codonopsis pilosula into sections, add 10 times amount of water, and boil 3 times, 1.5 hours each time. The decoctions are combined, filtered, and concentrated to a relative density of 1.25-1.30 (60° C.), 95% ethanol is added to make the alcohol content reach 75%, the mixture is allowed to stand for 12 hours, filtered, the precipitate is washed with anhydrous ethanol, and dried to obtain a polysaccharide extract of Codonopsis pilosula; rose flower is refluxed and extracted twice with 70% ethanol, each time for 1.5 hours, the amount of ethanol used is 6 times that of the medicinal material, the extracts are combined, the ethanol is recovered, and the mixture is concentrated to a relative density of 1.10-1.15 (60° C.), passed through a macroporous adsorption resin column, eluted with water and ethanol of different concentrations, the eluate containing total flavonoids is collected, concentrated and dried to obtain a total flavonoid extract of rose flower; volatile oil is extracted from ground shoots by steam distillation, the distillation time is 6 hours, the volatile oil is collected, and it is dehydrated with anhydrous sodium sulfate to obtain a volatile oil extract of ground shoots; 10 times the amount of 75% ethanol is added to epimedium, and refluxed and extracted 3 times, each time for 2 hours. The extracts are combined, ethanol is recovered, and the extracts are concentrated to a relative density of 1.20-1.25 (60° C.), purified by macroporous resin, and the eluate is concentrated and dried to obtain an epimedium flavonoid glycoside extract;

[0011] S2, preparation of auxiliary materials: decocting angelica with water for 3 times, each time for 2 hours, combining the decoctions, concentrating to a relative density of 1.30-1.35 (60°C), precipitating with alcohol, collecting the precipitate, drying to obtain polysaccharides, extracting angelica with ethanol by reflux, recovering ethanol, treating the concentrate with acid and alkali, extracting and separating ferulic acid, and mixing the polysaccharide and ferulic acid uniformly to obtain a complex of angelica polysaccharide and ferulic acid: extracting wolfberry with water for 3 times, each time for 1.5 hours, combining the extracts, concentrating, precipitating with alcohol, collecting the precipitate, and drying to obtain a mixture of wolfberry polysaccharides and carotenoids; after yam is crushed, it is separated and purified by water extraction, salting out, dialysis, ion exchange chromatography and other steps to obtain yam amylase inhibitor;

[0012] S3, mixing preparation: take purified water, heat it to 50-60°C, add ethyl acetate extract of Sargentodoxae, polysaccharide extract of Codonopsis pilosula, total flavonoid extract of Rosa chinensis, volatile oil extract of Radix Codonopsis pilosulae, flavonoid glycoside extract of Epimedium, complex of polysaccharide and ferulic acid of Angelica sinensis, mixture of polysaccharide and carotenoid of Lycium barbarum, amylase inhibitor of Chinese Yam, stir evenly, then add stevioside and potassium sorbate, stir until completely dissolved;

[0013] S4. Filtration and filling: The mixed solution is filtered through a 0.45 μm microporous filter membrane, and the filtrate is filled into 20 ml ampoules, 20 ml per bottle, and sealed with a crimp cap.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] The present invention is based on Chinese herbal medicine and integrates multiple active ingredients such as ethyl acetate extract of Sargentodoxae, polysaccharide extract of Codonopsis pilosula, and total flavonoids extract of rose. It comprehensively regulates the body from multiple dimensions, and the various ingredients work synergistically to improve the function of the female reproductive system in an all-round way and increase the probability of pregnancy. It can replenish blood and promote blood circulation, regulate the intrauterine environment, and help key reproductive links such as follicle development, ovulation, and implantation of fertilized eggs. At the same time, it also regulates the body to ensure that the body takes in enough nutrients, creates a good material basis for nurturing the fetus, strengthens the physical fitness, makes the body more suitable for pregnancy, reduces the extra burden on the patient's body due to adverse drug reactions, and has higher patient compliance, which is suitable for a longer period of conditioning and preparation for pregnancy.

[0016] At the same time, compared with traditional Chinese medicine decoctions, it does not require decocting, is convenient to take, and easy to carry. Patients can take it on time and in the right amount to ensure the regularity and continuity of treatment, which helps to improve the overall treatment effect and meet the medication needs of infertile patients in modern fast-paced life. DETAILED DESCRIPTION

[0017] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0018] Embodiment 1:

[0019] An oral liquid for treating infertility: comprising the following raw materials in percentages: 20% of Sargentodoxa cyrtonema, 20% of Codonopsis pilosula, 10% of Chinese rose, and 20% of ground bamboo shoots.

[0020] The preparation method comprises the following steps:

[0021] Wash and dry the medicinal materials of Sanguisorba officinalis, Codonopsis pilosula, Chinese rose and ground bamboo shoots, soak them in 38-degree warm low-alcohol wine, add 20-40g of the original medicine to every pound of wine, and also add appropriate amount of rock sugar to the low-alcohol wine.

[0022] Embodiment 2:

[0023] An oral liquid for treating infertility: comprising the following raw materials in percentage: 32% of ethyl acetate extract of Sargentodoxae cyrtonema, 28% of polysaccharide extract of Codonopsis pilosula, 12% of total flavonoids extract of Rosa chinensis, 10% of volatile oil extract of Asparagus cochinchinensis, 9% of flavonoid glycoside extract of Epimedium, 4.5% of complex of angelica polysaccharide and ferulic acid, 3% of mixture of wolfberry polysaccharide and carotenoid, 3% of yam amylase inhibitor, 0.3% of flavoring agent, 0.2% of preservative, and the balance is water.

[0024] A method for preparing an oral liquid for treating infertility comprises the following steps:

[0025] Raw material extraction

[0026] Ethyl acetate extract of Sanguisorba officinalis: Take 1000g of dried Sanguisorba officinalis, grind it into coarse powder, put it in a round-bottom flask, add 8 times the amount of ethyl acetate, and reflux extraction 3 times, each time for 2 hours. Combine the extracts, recover the ethyl acetate by vacuum distillation, and concentrate to a relative density of 1.20 (60°C), to obtain about 320g of ethyl acetate extract of Sanguisorba officinalis.

[0027] Polysaccharide extract of Radix Codonopsis pilosulae: Wash and cut 800g of Radix Codonopsis pilosulae into sections, add 10 times the amount of deionized water, and boil for 3 times, each time for 1.5 hours. Combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.25 (60°C). Add 95% ethanol to make the ethanol content reach 75%, let stand for 12 hours, filter, wash the precipitate with anhydrous ethanol 2-3 times, and dry to obtain about 280g of polysaccharide extract of Radix Codonopsis pilosulae.

[0028] Total flavonoids extract of Chinese rose: 500g of Chinese rose was extracted twice with 70% ethanol under reflux, each time for 1.5 hours, and the amount of ethanol used was 6 times that of the medicinal material. The extracts were combined, ethanol was recovered, and concentrated to a relative density of 1.10 (60°C). Purification was performed through a macroporous adsorption resin column, first eluted with water to remove impurities, then eluted with 30% ethanol to collect the eluate containing total flavonoids, concentrated under reduced pressure, and dried to obtain about 120g of total flavonoids extract of Chinese rose.

[0029] Ground shoot volatile oil extract: Take 600g of ground shoot, extract by steam distillation for 6 hours, collect the volatile oil, and dehydrate with anhydrous sodium sulfate to obtain about 100g of ground shoot volatile oil extract.

[0030] Epimedium flavonoid glycoside extract: 400g of epimedium, add 10 times the amount of 75% ethanol, reflux extraction 3 times, 2 hours each time. Combine the extracts, recover the ethanol, and concentrate to a relative density of 1.20 (60°C). Pass the concentrate through a macroporous resin column, elute with an appropriate concentration of ethanol, collect the eluate, concentrate, and dry to obtain about 90g of epimedium flavonoid glycoside extract.

[0031] Angelica polysaccharide and ferulic acid complex: 300g of Angelica sinensis is decocted in water for 3 times, each time for 2 hours, the decoctions are combined, concentrated to a relative density of 1.30 (60°C), ethanol is added to make the alcohol content reach 80%, and the mixture is allowed to stand overnight, filtered, and the precipitate is dried to obtain Angelica polysaccharide. Another 200g of Angelica sinensis is extracted with ethanol reflux, the ethanol is recovered, the concentrated solution is treated with acid and alkali, and ferulic acid is extracted, and the two are mixed evenly to obtain about 45g of Angelica polysaccharide and ferulic acid complex.

[0032] Lycium barbarum polysaccharide and carotenoid mixture: 300g of wolfberry was extracted with water for 3 times, each time for 1.5 hours. The extracts were combined, concentrated, and then ethanol was added to make the alcohol content reach 70%. The mixture was allowed to stand, filtered, precipitated and dried to obtain about 30g of the mixture of lycium barbarum polysaccharide and carotenoid.

[0033] Chinese yam amylase inhibitor: 200 g of Chinese yam is washed and crushed, and water is added and stirred evenly, and water extraction is performed. The extract is subjected to salting out, dialysis, ion exchange chromatography and other steps to obtain about 30 g of Chinese yam amylase inhibitor.

[0034] Mixing preparation: Add an appropriate amount of purified water to the preparation tank, heat to 50-60°C, and add the prepared ethyl acetate extract of Sargentodoxae, polysaccharide extract of Codonopsis pilosula, total flavonoid extract of Rosa chinensis, volatile oil extract of Radix Codonopsis pilosulae, flavonoid glycoside extract of Epimedium, complex of polysaccharide and ferulic acid of Angelica sinensis, mixture of polysaccharide and carotenoid of Lycium barbarum, and amylase inhibitor of Chinese Yam in turn, and stir evenly. Then add stevioside and potassium sorbate, and continue stirring for 30-40 minutes to ensure that all ingredients are fully dissolved and mixed.

[0035] Filtration and filling: The mixed solution is filtered through a 0.45μm microporous filter membrane to remove impurities. The filtrate is filled into 20ml brown glass bottles, 20ml per bottle, and sealed with a cap.

[0036] Sterilization: Put the filled oral liquid into a high pressure steam sterilizer and sterilize at 115℃ for 30 minutes. After cooling, sample and inspect, and pack and store after passing the inspection.

[0037] Embodiment three:

[0038] An oral solution for treating infertility, comprising the following raw materials in percentages:

[0039] 25% ethyl acetate extract of Sargentodoxae cyrtonema, 30% polysaccharide extract of Codonopsis pilosula, 12% total flavonoids extract of Rosa chinensis, 10% volatile oil extract of Asparagus cochinchinensis, 8% flavonoid glycoside extract of Epimedium, 6% complex of Angelica sinensis polysaccharide and ferulic acid, 4% mixture of Lycium barbarum polysaccharide and carotenoids, 3.5% amylase inhibitor of Chinese yam, 0.3% flavoring agent (stevioside), 0.2% preservative (potassium sorbate), and the balance is purified water.

[0040] Preparation steps:

[0041] Raw material extraction

[0042] Ethyl acetate extract of Sansambar formosana: 1000 g of Sansambar formosana was crushed and extracted twice with 7 times the amount of ethyl acetate at 60°C for 2 times, each time for 2.5 hours. The extracts were combined, the ethyl acetate was recovered under reduced pressure, and concentrated to a relative density of 1.18 (60°C).

[0043] Polysaccharide extract of Radix Codonopsis pilosulae: Cut 1200g of Radix Codonopsis pilosulae into sections, add 12 times the amount of water, and boil at 100°C for 3 times, each time for 1.5 hours. Combine the decoctions, concentrate to a relative density of 1.28 (60°C), add ethanol to make the alcohol content reach 80%, let stand for 12 hours, filter, wash the precipitate with anhydrous ethanol and dry.

[0044] Total flavonoids extract of Chinese rose: 500g of Chinese rose was extracted with 60% ethanol at 70℃ reflux for 3 times, each time for 1.5 hours, and the amount of ethanol was 8 times that of the medicinal material. The extracts were combined, the ethanol was recovered, and concentrated to a relative density of 1.12 (60℃). The extracts were passed through a macroporous adsorption resin column, first washed with water, and then eluted with 40% ethanol. The eluate was collected and concentrated to dryness.

[0045] Volatile oil extract of ground shoots: 600 g of ground shoots were extracted by steam distillation for 8 hours, the volatile oil was collected and dehydrated with anhydrous sodium sulfate.

[0046] Epimedium flavonoid glycoside extract: 400g of Epimedium, add 8 times the amount of 70% ethanol, reflux extraction at 75℃ for 3 times, 2 hours each time, combine the extracts, recover the ethanol, concentrate to a relative density of 1.22 (60℃), pass through a macroporous resin column, elute with 50% ethanol, collect the eluate, and concentrate and dry.

[0047] Angelica polysaccharide and ferulic acid complex: 400g of Angelica sinensis is decocted in water for 3 times, each time for 2 hours, the decoctions are combined and concentrated to a relative density of 1.32 (60°C), ethanol is added to make the alcohol content reach 75%, and the mixture is allowed to stand overnight, filtered, and the polysaccharide is precipitated and dried; another 300g of Angelica sinensis is extracted with ethanol reflux, the ethanol is recovered, the concentrated solution is treated with acid and alkali, and ferulic acid is extracted, and the two are mixed.

[0048] Lycium barbarum polysaccharide and carotenoid mixture: 350 g of wolfberry was extracted with water for 3 times, each time for 1.5 hours, the extracts were combined, concentrated, ethanol was added to make the alcohol content reach 75%, the mixture was allowed to stand, filtered, precipitated and dried.

[0049] Chinese yam amylase inhibitor: 300 g of Chinese yam was crushed and extracted with water, and the extract was subjected to salting out, dialysis and ion exchange chromatography.

[0050] Mixing and preparation: Take an appropriate amount of purified water, heat it to 55°C, add the above extracts, stevioside and potassium sorbate in sequence, and stir for 40 minutes.

[0051] Filtration sterilization: The mixed solution was filtered through a 0.45 μm microporous filter membrane and sterilized by moist heat at 115°C for 30 minutes.

[0052] Filling and packaging: After sterilization, fill into 20ml brown glass bottles while hot, 20ml per bottle, seal with cap, and package.

[0053] Among them, in the present invention, the Latin name of Dchisandra proping T. avar. sinensis

[0054] Myosoton aquaticum (L.) Moench.

[0055] Rosa chinensis Jacq.

[0056] Lycopus lucidus Turcz.exBenth.

[0057] Among the above medicinal materials:

[0058] Spatholobi: Spicy and bitter in taste, warm in nature, and enters the liver and stomach meridians. It has the effects of promoting qi and blood circulation, dispersing blood stasis and relieving pain. It can improve symptoms such as irregular menstruation and dysmenorrhea caused by qi stagnation and blood stasis in women. Menstrual disorders and poor menstrual discharge are often related to infertility. By removing blood stasis and promoting blood circulation, it can help regulate the circulation of qi and blood in the uterus and create a more favorable internal environment for conception.

[0059] Codonopsis pilosula: sweet, slightly bitter, warm in nature, and enters the spleen and lung meridians. It can strengthen the spleen and replenish qi, nourish the lungs and relieve cough, and promote lactation. In the preparation for pregnancy, Codonopsis pilosula can strengthen the spleen and stomach, promote the body to better transport and transform the essence of water and grain, provide sufficient nutrients for the reproductive system, and promote the biochemical activity of qi and blood, so that the body can maintain a good functional state, strengthen the physical fitness, and indirectly help conception; it also has a regulating effect on postpartum milk obstruction, which indirectly reflects its auxiliary role in regulating female reproductive physiology.

[0060] Rose: Sweet, light, slightly bitter, neutral in nature, belongs to the liver meridian. Good at promoting blood circulation and regulating menstruation, soothing the liver and relieving depression. It has good conditioning ability for amenorrhea, dysmenorrhea, scanty menstruation and other problems caused by liver depression, qi stagnation and blood stasis. If infertile patients have such endocrine disorders and menstrual diseases caused by poor blood circulation, rose can regulate the body's hormone levels, regularize the menstrual cycle, optimize the cyclical rhythm of the reproductive system, and increase the possibility of conception.

[0061] Ground shoots: sweet and spicy, warm in nature, and enter the liver and spleen meridians. It has the effects of promoting blood circulation, replenishing qi, and eliminating water. It can help women resolve blood stasis in the body, improve abdominal discomfort caused by blood stasis, and regulate menstrual blood volume; at the same time, its qi-replenishing effect cooperates with other medicinal materials to help improve the body's vitality, make the circulation of qi and blood smooth, prepare a relatively healthy body foundation for the embryo, and also has a positive significance for the qi and blood perfusion of reproductive organs such as the uterus.

[0062] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0063] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. An oral liquid for treating infertility, characterized in that: The invention comprises the following raw materials in percentage: 20%-40% ethyl acetate extract of Sargentodoxae cyrtonema, 20%-40% polysaccharide extract of Codonopsis pilosula, 10%-50% total flavonoids extract of Rosa chinensis, 20%-40% volatile oil extract of Asparagus cochinchinensis, 5%-15% flavonoid glycoside extract of Epimedium, 3%-10% complex of Angelica sinensis polysaccharide and ferulic acid, 3%-8% mixture of Lycium barbarum polysaccharide and carotenoid, 2%-6% amylase inhibitor of Chinese yam, 0.1%-0.5% flavoring agent, 0.05%-0.3% preservative and the balance is water.

2. An oral liquid for treating infertility according to claim 1, characterized in that: The invention comprises the following raw materials in percentages: 32% ethyl acetate extract of Sarcandra cuneae, 28% polysaccharide extract of Codonopsis pilosula, 12% total flavonoids extract of Rosa chinensis, 10% volatile oil extract of Asparagus cochinchinensis, 9% flavonoid glycoside extract of Epimedium, 4.5% complex of Angelica sinensis polysaccharide and ferulic acid, 3% mixture of Lycium barbarum polysaccharide and carotenoid, 3% amylase inhibitor of Chinese yam, 0.3% flavoring agent, 0.2% preservative, and the balance is water.

3. A method for preparing an oral liquid for treating infertility according to any one of claims 1-2, characterized in that: The following steps are involved: S1. Preparation of extract: Take crude powder of Sansambar formosana, add 8 times amount of ethyl acetate, reflux extraction 3 times, 2 hours each time, combine the extracts, and concentrate under reduced pressure to a relative density of 1.15-1.20 (60°C) to obtain ethyl acetate extract of Sansambar formosana; cut Codonopsis pilosula into sections, add 10 times amount of water, and boil 3 times, 1.5 hours each time. The decoctions are combined, filtered, and concentrated to a relative density of 1.25-1.30 (60° C.), 95% ethanol is added to make the alcohol content reach 75%, the mixture is allowed to stand for 12 hours, filtered, the precipitate is washed with anhydrous ethanol, and dried to obtain a polysaccharide extract of Codonopsis pilosula; rose flower is refluxed and extracted twice with 70% ethanol, each time for 1.5 hours, the amount of ethanol used is 6 times that of the medicinal material, the extracts are combined, the ethanol is recovered, and the mixture is concentrated to a relative density of 1.10-1.15 (60° C.), passed through a macroporous adsorption resin column, eluted with water and ethanol of different concentrations, the eluate containing total flavonoids is collected, concentrated and dried to obtain a total flavonoid extract of rose flower; volatile oil is extracted from ground shoots by steam distillation, the distillation time is 6 hours, the volatile oil is collected, and it is dehydrated with anhydrous sodium sulfate to obtain a volatile oil extract of ground shoots; 10 times the amount of 75% ethanol is added to epimedium, and refluxed and extracted 3 times, each time for 2 hours. The extracts are combined, ethanol is recovered, and the extracts are concentrated to a relative density of 1.20-1.25 (60° C.), purified by macroporous resin, and the eluate is concentrated and dried to obtain an epimedium flavonoid glycoside extract; S2, preparation of auxiliary materials: decocting angelica with water for 3 times, each time for 2 hours, combining the decoctions, concentrating to a relative density of 1.30-1.35 (60°C), precipitating with alcohol, collecting the precipitate, drying to obtain polysaccharides, extracting angelica with ethanol by reflux, recovering ethanol, treating the concentrate with acid and alkali, extracting and separating ferulic acid, and mixing the polysaccharide and ferulic acid uniformly to obtain a complex of angelica polysaccharide and ferulic acid: extracting wolfberry with water for 3 times, each time for 1.5 hours, combining the extracts, concentrating, precipitating with alcohol, collecting the precipitate, and drying to obtain a mixture of wolfberry polysaccharides and carotenoids; after yam is crushed, it is separated and purified by water extraction, salting out, dialysis, ion exchange chromatography and other steps to obtain yam amylase inhibitor; S3, mixing preparation: take purified water, heat it to 50-60°C, add ethyl acetate extract of Sargentodoxae, polysaccharide extract of Codonopsis pilosula, total flavonoid extract of Rosa chinensis, volatile oil extract of Radix Codonopsis pilosulae, flavonoid glycoside extract of Epimedium, complex of polysaccharide and ferulic acid of Angelica sinensis, mixture of polysaccharide and carotenoid of Lycium barbarum, amylase inhibitor of Chinese Yam, stir evenly, then add stevioside and potassium sorbate, stir until completely dissolved; S4. Filtration and filling: The mixed solution is filtered through a 0.45 μm microporous filter membrane, and the filtrate is filled into 20 ml ampoules, 20 ml per bottle, and sealed with a crimp cap.