Synthetic method of 3-methylaminopropionic acid
By using trimethyl phosphate to perform the N-methylation reaction under hexafluoroisopropanol catalyzed by converting 3-aminopropanoate into 3-methylaminopropanoate, the problems of strict reaction conditions and insufficient product purity in the prior art were solved, and high yield synthesis and low cost production of 3-methylaminopropanoic acid were achieved.
Patent Information
- Application Number
- CN202510151816.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-12
- Publication Date
- 2025-05-23
- Estimated Expiration
- 2045-02-12
AI Technical Summary
The existing 3-methylaminopropionic acid synthesis methods have problems such as strict reaction conditions, high raw material costs and insufficient product purity, resulting in low production efficiency and high cost.
Trimethyl phosphate was used as the N-methylation reagent, and 3-aminopropionate was converted into 3-methylaminopropionate under the catalyzed by hexafluoroisopropyl alcohol, and the high yield synthesis of 3-methylaminopropionate was achieved through N-alkylation and saponification reactions.
The method is simple to operate, mild conditions, and easy to separate the product, which can achieve high yield synthesis of 3-methylaminopropionic acid, improves synthesis efficiency and selectivity, and reduces raw material costs.
Smart Images
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Abstract
Claims
1. A method for synthesizing 3-methylaminopropionic acid, characterized in that: 3-aminopropionic acid ester is dissolved in hexafluoroisopropanol to form a uniform solution, trimethyl phosphate is added dropwise to the solution to carry out N-alkylation reaction, after the N-alkylation reaction is completed, alkali solution is added to carry out saponification, and the saponification product is acidified to obtain the obtained solution.
2. A method for synthesizing 3-methylaminopropionic acid according to claim 1, characterized in that: The 3-aminopropionic acid ester has the following molecular structure: , wherein R is a C1~C5 alkyl group.
3. A method for synthesizing 3-methylaminopropionic acid according to claim 1, characterized in that: The concentration of 3-aminopropionic acid ester in the solution is ≤0.5 mol / L.
4. A method for synthesizing 3-methylaminopropionic acid according to claim 1, characterized in that: The molar ratio of the methyl 3-aminopropionate to the trimethyl phosphate is 1:1.0-1.
1.
5. A method for synthesizing 3-methylaminopropionic acid according to claim 1, characterized in that: The addition rate of the trimethyl phosphate is controlled to be 5-10s per drop.
6. A method for synthesizing 3-methylaminopropionic acid according to any one of claims 1 to 5, characterized in that: The conditions of the N-alkylation reaction are: temperature of 0-60° C. and time of 1-4 hours.
7. A method for synthesizing 3-methylaminopropionic acid according to any one of claims 1 to 5, characterized in that: The saponification reaction conditions are: temperature of 80-110° C. and time of 2-3 hours.
Citation Information
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