Sample analyzer
By integrating the reagent bin module and the sample analysis device on the rack, the existing automatic immunoassay device has been solved, and the equipment is miniaturized and simplified.
Patent Information
- Application Number
- CN202311564150.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-21
- Publication Date
- 2025-05-23
AI Technical Summary
The existing automatic immunoassay devices have problems such as large size, complex structure, large space and complex operation.
A sample analysis device is designed to achieve compact layout and automated operation between modules by integrating the reagent bin module, injection module, cup processing module, incubation module, transfer module and detection module on the rack.
It effectively saves the layout space of the entire machine, simplifies the operation process, improves the detection efficiency and automation level, and realizes the miniaturization of the equipment.
Smart Images

Figure CN120028560A_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a sample analysis device. Background Art
[0002] The basic principle of immunodiagnosis is to apply immunological technology, that is, the specific combination of antigens and antibodies to diagnose pathogens, mainly covering the fields of virus and blood source inspection, hepatitis detection, STD monitoring (HIV, etc.), tumor detection, etc. Automatic immunoassay analyzer is an instrument used to quantitatively analyze target analytical substances such as antibodies and antigens contained in test samples such as blood. Its working process is usually to add the test sample and reagent to the reaction cup, and after mixing, incubation, washing and separation, add the labeled signal reagent to the reaction cup to measure its labeled signal to achieve measurement and analysis of the target contained in the test sample. Some immunoassay analyzers are equipped with opening and closing mechanisms, as well as various centrifugal-related mechanisms, such as reaction centrifugal cup accommodating mechanisms, reaction centrifugal cup conveying mechanisms, centrifugal mechanisms, etc. There are many equipment components, and the modules are relatively loosely set, resulting in a large volume; in addition, the reaction cups of some immunoassay analyzers need to be manually placed on the reaction cup placement rack in advance, and then the reaction cup is transferred by the transfer of the mechanical arm, including the reaction cup placement rack and the mechanical transmission module. The layout of each module is unreasonable, resulting in a large volume of equipment. Therefore, there is an urgent need to develop an immunoassay analyzer to solve the problems of large size, complex structure, large space occupied and complex operation of the automatic immunoassay analyzer in the prior art. Summary of the invention
[0003] The main purpose of the present invention is to provide a sample analysis device, aiming to solve the technical problems of the sample analysis device in the prior art being complex in structure and occupying a large space.
[0004] In order to achieve the above-mentioned object, the present invention provides a sample analysis device, including a frame and:
[0005] Reagent storage module, used to store reagents required during the reaction process;
[0006] A sampling module for storing sample tubes;
[0007] The cup sorting module is used to sort out the empty reaction cups and place them vertically down to the unloading end one by one;
[0008] An incubation module is connected to the unloading end of the cup sorting module, and is used to receive and hold the empty reaction cups delivered by the cup sorting module;
[0009] A transfer module moves between the reagent compartment module, the injection module and the incubation module, and is used to transfer the sample in the injection module and the reagent in the reagent compartment module to the reaction cup in the incubation module, and the incubation module is used to mix and incubate the reagent and sample in the reaction cup; and
[0010] The detection module is used to detect the reagents that have completed the incubation reaction in the incubation module.
[0011] In one embodiment, the reagent chamber module includes a chamber body, a mixing mechanism, a first refrigeration unit, a second refrigeration unit, and a third driving mechanism; the mixing mechanism is arranged inside the chamber body and is used to mix the sample; the first refrigeration unit and the second refrigeration unit are used to cool the chamber body and are arranged below the chamber body at intervals from each other in the horizontal direction, and the first refrigeration unit and the second refrigeration unit are both distributed in the longitudinal direction; the third driving mechanism is arranged between the first refrigeration unit and the second refrigeration unit and includes a driving motor, a driving shaft and a synchronous pulley assembly distributed in the longitudinal direction, the top end of the driving shaft penetrates upward through the bottom wall of the chamber body and is connected to the mixing mechanism, the bottom end of the driving shaft is connected to the synchronous pulley assembly, and the driving motor is arranged vertically and is used to drive the synchronous pulley assembly.
[0012] In one embodiment, the reagent chamber module also includes a sample tube and a reset assembly; the sample tube is detachably inserted into the mixing mechanism; the reset assembly is used to reset the mixing mechanism and includes a reset optical coupling piece and a reset optical coupling piece; the reset optical coupling piece is arranged at the top or bottom of the driven wheel of the synchronous pulley assembly and forms a first detection part; the reset optical coupling piece is arranged on the side of the driven wheel away from the driving motor and is used to detect the first detection part; the position detection assembly is used to detect the rotational position of the sample tube and includes a position detection optical coupling piece and a position detection optical coupling piece; the position detection optical coupling piece is arranged on the driven wheel and is vertically spaced from the reset optical coupling piece, and a plurality of second detection parts distributed along the circumferential direction are formed on the position detection optical coupling piece; the position detection optical coupling piece and the reset optical coupling piece are vertically spaced and are used to detect the second detection part.
[0013] In one embodiment, the reagent chamber module also includes a first cold insulation plate, a motor mounting seat, an optical coupler mounting seat and a second cold insulation plate; the first cold insulation plate is arranged at the bottom of the chamber body; the motor mounting seat is arranged below the first cold insulation plate, and a first installation cavity is formed between the motor mounting seat and the first cold insulation plate, and the driving wheel of the synchronous pulley assembly is installed in the first installation cavity along the horizontal direction, and the driving end of the driving motor passes upward through the bottom wall of the motor mounting seat and is connected to the driving wheel; the optical coupler mounting seat is used to install the reset optical coupler and the position detection optical coupler; the second cold insulation plate is arranged below the chamber body and is used to install the optical coupler mounting seat.
[0014] In one embodiment, the injection module comprises:
[0015] A mounting platform is provided with a sample conveying area and a cover opening area located on a lateral side of the sample conveying area;
[0016] A sample tray is longitudinally movably disposed in the sample conveying area and is formed with a first conveying channel for loading the sample rack;
[0017] A sampling track, which is arranged in the open cover area in a transverse direction and can be communicated with the first conveying channel;
[0018] A first driving mechanism is disposed below the sampling track and is used to drive the sample rack on the sample tray to move back and forth between the first conveying channel and the sampling track;
[0019] A clamping mechanism, arranged in the cover opening area and located on one longitudinal side of the sampling track, for clamping the tube body of the sample tube;
[0020] The cover opening mechanism is arranged in the cover opening area and located on the side of the pressing mechanism away from the sampling track, and is used to open the tube cover of the sample tube.
[0021] In one embodiment, there are multiple first conveying channels, and the injection module also includes a sensing device and a second driving mechanism; the sensing device is used to sense the sample rack entering the first conveying channel; the second driving mechanism is used to drive the sample tray to move to a position where the first conveying channel is flush with the sampling track.
[0022] In one embodiment, the sampling module also includes a lifting mechanism and a connecting arm. The lifting mechanism can be lifted and lowered on the mounting platform and is located on the side of the clamping mechanism away from the sample rack. The connecting arm is arranged on the top of the lifting mechanism; the cover opening mechanism includes a cover opening drive, a pivot shaft, and two clamping parts. The pivot shaft is vertically arranged on the connecting arm. The clamping part includes a connecting part and a clamping part. The upper end of the clamping part is connected to the connecting part and can clamp the tube cover of the sample tube from the upper and lower ends. The connecting part is rotatably arranged on the pivot shaft in the horizontal direction. A clamping space for clamping the tube cover is formed between the two clamping parts. The cover opening drive is horizontally arranged above the connecting arm and is used to drive the two clamping parts to approach or move away from each other.
[0023] In one embodiment, the incubation module includes an incubation disk, a stirring assembly, an optical coupling assembly and a control unit; the incubation disk includes a rotating disk and a reaction disk, the rotating disk is provided with a plurality of through holes along the circumference for accommodating reaction cups, and a reaction cup accommodating station for inserting the bottom of the reaction cup is formed on the reaction disk; the stirring assembly is installed under the reaction disk and is used to stir and mix the reagents and samples in the reaction cup; the second rotary drive assembly is used to drive the rotating disk to rotate; the optical coupling assembly is arranged on the reaction disk and obtains the corresponding position information of the through holes and the reaction cup accommodating station and sends a judgment signal; the control unit is electrically connected to the optical coupling assembly and controls the action of the second rotary drive assembly according to the received judgment signal, so that the through holes and the reaction cup accommodating stations correspond one to one.
[0024] In one embodiment, the rotating disk includes a rotating ring coaxially spaced on the inner periphery of the reaction disk and a rotating cover plate covered on the rotating ring, the rotating cover plate is provided with a cover body, and the incubation module further includes:
[0025] Mounting table;
[0026] The cleaning and liquid injection components are at least two in number and are arranged on the mounting table along an arc-shaped interval. In the rotation direction of the rotating cover plate, the cleaning and liquid injection component located at the last position is used to absorb the remaining liquid in the reaction cup, and the remaining cleaning and liquid injection components are used to absorb the liquid in the reaction cup and inject cleaning liquid;
[0027] The lifting drive assembly is installed on the cover body and is used to drive the installation platform to rise and fall.
[0028] In one embodiment, the cleaning and injection assembly includes:
[0029] A guide sleeve movably passes through the mounting table; and a reaction needle integrated in the guide sleeve, the reaction needle is used to absorb the liquid in the reaction cup or inject cleaning liquid into the reaction cup, the reaction needle located at the last position includes an absorption needle for absorbing the liquid in the reaction cup, and the remaining reaction needles include an injection needle for injecting cleaning liquid into the reaction cup and an absorption needle for absorbing the liquid in the reaction cup, and the plane where the bottom of the absorption needle is located is higher than the plane where the bottom of the injection needle is located.
[0030] In one embodiment, the optical coupling component includes:
[0031] There are multiple position matching parts, which are arranged on the rotating disk along the circumferential direction and correspond to the reaction cup receiving stations one by one;
[0032] A position optical coupler, which cooperates with the position matching component to obtain the position information of the reaction cup receiving station and sends a judgment signal according to the position information; and
[0033] The reset optical coupler is arranged on the reaction disk, and a light blocking column is arranged on the rotating disk. The reset optical coupler and the light blocking column cooperate to detect whether the rotating disk reaches the reset initial position.
[0034] In one embodiment, the cup sorting module includes a reaction cup loading bin, a cup sorting drum, a baffle, a first rotation drive assembly and a cup pushing mechanism; the reaction cup loading bin is used to hold the reaction cups; a plurality of partition sections are arranged at intervals on the inner circumferential wall of the cup sorting drum, and the partition sections are arranged obliquely relative to the inner circumferential wall of the cup sorting drum, and a guide channel is formed between any two adjacent partition sections, and the feed end of the guide channel is connected to the discharge end of the reaction cup loading bin; the baffle is located on the side of the cup sorting drum away from the reaction cup loading bin, and a cup outlet for the reaction cups to be discharged is opened on the baffle; the first rotation drive assembly is used to drive the cup sorting drum to rotate, so as to drive the discharge end of each guide channel to rotate to the The cup pushing mechanism comprises a conveying assembly and a cup pushing assembly, wherein the conveying assembly forms a cup dropping opening and a second conveying channel connected to the cup dropping opening, and the cup pushing assembly is used to push the reaction cups in the second conveying channel to the cup dropping opening in sequence; the cup pushing assembly comprises a pushing member, a guide rail, a second linear driving member and a first linear driving member; the guide rail is installed on the outer side wall of the conveying guide block along a first direction; the second linear driving member is used to drive the pushing member to approach or move away from the reaction cup in the cup dropping channel along a second direction, and the first direction and the second direction intersect; the first linear driving member is installed on the guide rail and is used to drive the second linear driving member to move linearly along the first direction.
[0035] In one embodiment, the sample analysis device further comprises a cup discarding module, which is used to grab the remaining liquid in the reaction cup after the reaction in the incubation module is completed, and discard the discarded reaction cup to the waste recovery module;
[0036] The cup-throwing module includes a gripping mechanism, a cup-throwing pushing block, a lifting drive mechanism and a translation mechanism; the gripping mechanism includes an elastic clamping member, a lifting plate and two clamping bodies slidably connected to the lifting plate, the two clamping bodies are arranged opposite to each other along a third direction and surround a clamping groove, the two ends of the elastic clamping member are respectively connected to the two clamping bodies, rollers for rolling contact with the cup-throwing pushing block are installed on the clamping bodies, the two clamping bodies surround an avoidance groove for the cup-throwing pushing block to extend into, and the rollers are arranged close to the avoidance groove; the cup-throwing pushing block is located between the two clamping bodies and is used to abut the two clamping bodies, The two clamping bodies are made to slide opposite to each other along the third direction; the lifting drive mechanism is used to drive the lifting plate to reciprocate between the grabbing position and the cup throwing position along the fourth direction relative to the cup throwing push block; the reaction cup can extend into the clamping groove located at the grabbing position and tension the elastic clamping piece, so that the elastic clamping piece applies an elastic clamping force to the clamping body, and the cup throwing push block can squeeze the clamping body located at the cup throwing position, and make the two clamping bodies slide opposite to each other along the third direction to overcome the elastic clamping force and release the reaction cup; the translation mechanism is used to drive the lifting drive mechanism and the grabbing mechanism to translate synchronously along the third direction.
[0037] Through the above technical solution, the sample analysis device provided by the embodiment of the present invention has the following beneficial effects:
[0038] The sample analysis device of the present application integrates multiple modules on a rack, which can effectively save the layout space of the whole machine and is conducive to the miniaturization of the equipment; and the reagent compartment module is used to store the reagents required in the reaction process; the injection module is used to store the sample tubes; the cup arrangement module is used to sort out the empty reaction cups and vertically lower the empty reaction cups to the unloading end in turn; the incubation module is connected to the unloading end of the cup arrangement module, and the incubation module is used to receive and accommodate the empty reaction cups transported by the cup arrangement module; the transfer module moves between the reagent compartment module, the injection module and the incubation module, the transfer module is used to transfer the sample in the injection module and the reagent in the reagent compartment module to the reaction cup in the incubation module, and the incubation module is used to mix the reagents and samples in the reaction cup for incubation reaction; the detection module is used to detect the reagents that have completed the incubation reaction in the incubation module, and the entire detection process is simple to operate, improves the detection efficiency, and has a high degree of automation. BRIEF DESCRIPTION OF THE DRAWINGS
[0039] Figure 1 is a schematic structural diagram of a sample analysis device according to an embodiment of the present invention; Figure 2 is a schematic structural diagram of a reagent compartment module according to the present invention from a first viewing angle; Figure 3 is a schematic structural diagram of a reagent compartment module according to the present invention at a second viewing angle; Figure 4 is a schematic structural diagram of a reagent compartment module according to the present invention at a third viewing angle; Figure 5 is a schematic diagram of a first cross-sectional structure of a reagent compartment module according to the present invention; Figure 6 is a schematic diagram of a second cross-sectional structure of a reagent compartment module according to the present invention; Figure 7 is a schematic structural diagram of a sampling module according to the present invention at a first viewing angle; Figure 8 is a schematic structural diagram of the sampling module according to the present invention at a second viewing angle; Fig. 9 It is a schematic diagram of the overall structure of the lifting mechanism and the angle adjustment mechanism in the injection module according to the present invention; Fig.10 is a schematic structural diagram of a pressing mechanism in a sample injection module according to the present invention; Fig.11 is a structural schematic diagram of a cup sorting module according to the present invention from a first viewing angle; Fig.12 is a structural schematic diagram of a cup sorting module according to the present invention at a second viewing angle; Fig.13 is a partial structural schematic diagram of a cup sorting module according to the present invention; Fig.14 is a schematic structural diagram of an incubation module according to the present invention; Fig.15 is a schematic structural diagram of an incubation module without a cover according to the present invention; Fig.16 is a schematic diagram of the structure of the incubation module according to the present invention after the reaction disk is removed; Fig.17 is a schematic diagram of the structure of the incubation module according to the present invention after the rotating cover is removed; Fig.18 is a schematic structural diagram of a rotating cover plate in an incubation module according to the present invention; Fig.19is a structural schematic diagram of a cup-throwing module according to the present invention; Fig. 20 is a partial structural schematic diagram of a cup-throwing module according to the present invention; Fig.21 It is a partial structural schematic diagram of the grabbing mechanism in the cup-losing module according to the present invention.
[0040] Description of Reference Numerals
[0041] 100, reagent chamber module; 1, chamber body; 2, mixing mechanism; 201, rotating disk; 2011, fixed gear; 2031, rotating gear, 2032, rotating shaft; 20, second cold plate; 3, first refrigeration unit; 4, second refrigeration unit; 501, first drive motor; 503, drive shaft; 502, synchronous pulley assembly; 6, semiconductor refrigeration plate; 7, heat sink; 8, cooling fan; 10, support column; 13, first cold plate; 14, motor mounting seat; 15, first mounting cavity; 1601, reset optical coupling sheet; 1602, reset optical coupling; 17, sample tube; 1801, position detection optical coupling sheet; 1802, position detection optical coupling; 19, optical coupling mounting seat; 26, chamber body temperature detector; 27, chamber interior Temperature detector; 28, temperature detector mounting seat; 200, sampling module; 21, mounting platform; 22, sample conveying area; 23, opening cover area; 202, sample tray; 203, sample rack; 204, sampling track; 206, clamping mechanism; 2061, clamping drive assembly; 2062, pressing wheel assembly; 2063, clamping seat; 2064, first guide rail; 2065, first slider; 208, opening cover mechanism; 2081, opening cover drive member; 2082, pivot shaft; 2083, clamping member; 209, conventional sample channel; 210, emergency sample channel; 211, conventional sample sensor; 212, emergency sample sensor; 213, second drive mechanism; 2131, first transmission assembly; 2132 , threaded rod; 216, second in-place detection baffle; 217, second in-place detector; 220, lifting mechanism; 221, connecting arm; 222, screw motor; 223, first hook pull part; 224, angle adjustment mechanism; 300, cup sorting module; 301, reaction cup loading bin; 302, cup sorting drum; 303, guide channel; 304, partition section; 305, baffle; 306, first rotary drive assembly; 307, cup pushing assembly; 3071, pushing member; 3072, guide rail; 3073, first linear drive member; 3074, second linear drive member; 308, cup outlet; 309, second conveying channel; 310, conveying guide block; 311, tilting plate; 312, judgment optical coupler; 313, cup drop channel; 314, cup drop bucket; 315, cup drop mouth; 400, incubation module; 401, stirring assembly; 4011, first rotary drive member; 4012, stirring adapter shaft; 4013, stirring oscillation shaft; 402, second rotary drive assembly; 403, rotating disk; 4031, rotating ring; 4032, rotating cover plate; 404, reaction disk; 405, through hole; 406, reaction cup receiving station; 407, mounting table; 408, cleaning and injection assembly; 4081, suction needle; 4082, injection needle; 4083, mounting block; 4084, guide column; 4085, elastic member; 409, lifting drive assembly; 410, reaction hole position; 411, position optical coupler; 412, reset optical coupler; 500, transfer module;600, detection module; 700, reaction cup; 800, cup throwing module; 801, grabbing mechanism; 8011, elastic clamping member; 8012, lifting plate; 8013, clamping body; 8014, first horizontal guide rail; 8015, wear-resistant slider; 8016, second connecting plate; 8017, roller; 8018, positioning column; 802, cup throwing push block; 803, lifting drive mechanism; 804, translation mechanism; 8041, translation drive member; 8042, horizontal support plate; 8043, tension adjustment component; 805, bracket. ; DETAILED DESCRIPTION
[0042] like Figure 1 As shown, the sample analysis device of the present invention comprises a rack and a reagent compartment module 100, a sample injection module 200, a cup arrangement module 300, an incubation module 400, a transfer module 500 and a detection module 600 arranged on the rack; the reagent compartment module 100 is used to store reagents required in the reaction process; the sample injection module 200 is used to store sample tubes 17; the cup arrangement module 300 is used to sort out empty reaction cups 700 and vertically lower the empty reaction cups 700 to the unloading end in sequence; the incubation module 400 is connected to the unloading end of the cup arrangement module 300, and the incubation module 400 is used to receive and hold the empty reaction cup 700 delivered by the cup management module 300; the transfer module 500 moves between the reagent compartment module 100, the injection module 200 and the incubation module 400, and the transfer module 500 is used to transfer the sample in the injection module 200 and the reagent in the reagent compartment module 100 to the reaction cup 700 in the incubation module 400, and the incubation module 400 is used to mix and incubate the reagent and sample in the reaction cup 700; the detection module 600 is used to detect the reagent that has completed the incubation reaction in the incubation module 400. The sample analysis device of the present application integrates multiple modules on the frame, which can effectively save the layout space of the whole machine, is conducive to the miniaturization of the equipment, and is simple to operate, improves the detection efficiency, and has a high degree of automation.
[0043] like Figures 2 to 5 As shown, the reagent bin module 100 includes a bin body 1, a mixing mechanism 2, a first refrigeration unit 3, a second refrigeration unit 4, and a third driving mechanism arranged between the first refrigeration unit 3 and the second refrigeration unit 4; the mixing mechanism 2 is arranged inside the bin body 1 and is used to mix the reagent; the first refrigeration unit 3 and the second refrigeration unit 4 are used to refrigerate the bin body 1 and are arranged below the bin body 1 at intervals from each other in the horizontal direction, and the first refrigeration unit 3 and the second refrigeration unit 4 are both distributed in the longitudinal direction; the third driving mechanism includes a first driving motor 501, a driving shaft 503 and a synchronous pulley assembly 502 distributed in the longitudinal direction, the top end of the driving shaft 503 penetrates the bottom wall of the bin body 1 upward and is connected to the mixing mechanism 2, the bottom end of the driving shaft 503 is connected to the synchronous pulley assembly 502, and the first driving motor 501 is arranged vertically and is used to rotate and drive the synchronous pulley assembly 502.
[0044] Specifically, the reagents for the reaction are stored inside the warehouse body 1, and the first refrigeration unit 3 and the second refrigeration unit 4 cool the warehouse body 1 so that a good refrigeration environment is formed inside the warehouse body 1, thereby facilitating the provision of a good storage environment for the reagents and ensuring that the reagents have sufficient activity before being analyzed; when the first drive motor 501 rotates, the power is transmitted to the synchronous pulley assembly 502 and the drive shaft 503 in turn, and the drive shaft 503 then drives the mixing mechanism 2 to move to mix the reagents. When the mixing mechanism 2 moves, it can not only mix the reagents to further improve the accuracy of the sample analysis, but also disturb the air in the warehouse body 1, so that the temperature at each position inside the warehouse body 1 is more uniform, so as to further improve the storage environment of the sample.
[0045] That is, the reagent bin module 100 in this embodiment has a simple structure. The layout of the first drive motor 501, the synchronous pulley assembly 502, the drive shaft 503, the first refrigeration unit 3 and the second refrigeration unit 4 makes more effective use of the space below the bin body 1. The layout is compact, which is beneficial to reducing the overall height of the reagent bin module 100, and is beneficial to achieving a miniaturized design to reduce occupied space. It also has the advantages of low cost and easy production and manufacturing.
[0046] Among them, the synchronous pulley assembly 502 includes a driving wheel, a driven wheel and a synchronous belt. The driving wheel is drive-connected to the driving end of the first driving motor 501. The driven wheel and the driving wheel are spaced apart in the longitudinal direction and connected to the bottom end of the driving shaft 503. The synchronous belt is sleeved on the outside of the driving wheel and the driven wheel.
[0047] In one embodiment of the present invention, the first refrigeration unit 3 and the second refrigeration unit 4 both include a semiconductor refrigeration sheet 6, a heat sink block 7 and a heat dissipation fan 8; the semiconductor refrigeration sheet 6 is arranged below the warehouse body 1; the heat sink block 7 is longitudinally arranged below the semiconductor refrigeration sheet 6 and is formed with a plurality of heat dissipation grooves that are laterally spaced apart, and the heat dissipation grooves are axially connected; the heat dissipation fan 8 is arranged adjacent to one longitudinal side of the heat dissipation groove.
[0048] The semiconductor cooling sheet 6 includes a heat absorbing part and a heat dissipating part. The heat absorbing part is arranged below the storage body 1 and is used to absorb the heat dissipated by the storage body 1. The heat dissipating part is arranged below the heat absorbing part and is used to conduct the heat dissipated by the storage body 1. During the sample storage process, the heat absorbing part of the semiconductor cooling sheet 6 absorbs the heat of the storage body 1, so that the temperature inside the storage body 1 decreases. The heat absorbing part transfers the absorbed heat to the heat dissipating part, and the heat dissipating part then transfers the above heat to the heat dissipating block 7. Further, the heat dissipating block 7 includes a plurality of heat dissipating fins distributed laterally at intervals, and a heat dissipating groove is formed between two adjacent heat dissipating fins. The single heat dissipating fins on the heat dissipating block 7 are distributed vertically, and the heat dissipating area is large, which is conducive to improving the heat dissipation effect of the fins. The two adjacent heat dissipating fins then transfer their heat to the air in the heat dissipating groove between them. When the heat dissipating fan 8 is working, it can disturb the air in the heat dissipating groove. Under the action of the heat dissipating fan 8, the above air quickly flows out of the heat dissipating groove and takes away the heat.
[0049] In one embodiment of the present invention, the reagent bin module 100 further includes three support columns 10 spaced apart below the bin body 1, one of the support columns 10 being located between the first refrigeration unit 3 and the second refrigeration unit 4 in the horizontal direction, and the other two support columns 10 being located on both sides of the first drive motor 501 and at the longitudinal end of the heat sink 7 away from the first support column 10. Specifically, the above arrangement can avoid installation interference between the three support columns 10 and other components below the bin body 1, and can also avoid the first support column 10 blocking the air inlet of the heat sink fan 8, thereby affecting the air intake efficiency of the heat sink fan 8, and avoiding reducing the heat dissipation efficiency of the heat sink 7.
[0050] In one embodiment of the present invention, the reagent bin module 100 further includes a first cold-isolating plate 13 disposed at the bottom of the bin body 1, and a motor mounting seat 14 disposed below the first cold-isolating plate 13; a first mounting cavity 15 is formed between the motor mounting seat 14 and the first cold-isolating plate 13; the driving wheel of the synchronous pulley assembly 502 is mounted in the first mounting cavity 15 in a horizontal direction, and the driving end of the first driving motor 501 passes upward through the bottom wall of the motor mounting seat 14 and is drivingly connected to the driving wheel. The above arrangement can block the heat or cold transfer between the bin body 1 and the first driving motor 501, thereby avoiding the temperature rise in the bin body 1, further improving the refrigeration efficiency of the first refrigeration unit 3 and the second refrigeration unit 4, and can also avoid the first driving motor 501 being affected by the cold from the bin body 1 and reducing its performance.
[0051] Furthermore, in the present embodiment, the first cold-isolating plate 13 may be made of polyoxymethylene material. The first cold-isolating plate 13 made of such material is conducive to further improving the difficulty of transferring heat or cold between the warehouse body 1 and the first driving motor 501 .
[0052] In one embodiment of the present invention, the reagent chamber module 100 also includes a reset component for resetting the mixing mechanism 2, and the reset component includes a reset optical coupling piece 1601 and a reset optical coupling piece 1602; the reset optical coupling piece 1601 is arranged at the top or bottom of the driven wheel of the synchronous pulley assembly 502 and forms a first detection part; the reset optical coupling piece 1602 is arranged on the side of the driven wheel away from the first drive motor 501 and is used to detect the first detection part.
[0053] Specifically, the reagent compartment module 100 also includes a sample tube 17, and the mixing mechanism 2 includes a sample tube mounting seat. The sample tube 17 is detachably inserted into the sample tube mounting seat. In this embodiment, the reset optical coupling piece 1601 is set at the bottom of the driven wheel, and the first detection part is a raised baffle. The reset optical coupling piece 1601 rotates with the driven wheel, and the reset optical coupling 1602 is set on the outer peripheral side of the reset optical coupling piece 1601 and is used to sense the above-mentioned raised baffle. Before the operator inserts the sample tube 17 into the sample tube mounting seat, the mixing mechanism 2 is reset by the reset component. The sample tube mounting seat takes the position when the mixing mechanism 2 is in the reset state as the zero position.
[0054] In one embodiment of the present invention, the reagent chamber module 100 also includes a sample tube 17 and a position detection assembly, and the sample tube 17 is detachably inserted into the mixing mechanism 2; the position detection assembly is used to detect the rotational position of the sample tube 17 and includes a position detection optical coupling sheet 1801 and a position detection optical coupling 1802; the position detection optical coupling sheet 1801 is arranged on the top of the driven wheel and is vertically spaced from the reset optical coupling sheet 1601, and a plurality of second detection parts distributed along the circumferential direction are formed on the position detection optical coupling sheet 1801; the position detection optical coupling 1802 is vertically spaced from the reset optical coupling 1602 and is used to detect the second detection part. Specifically, the position detection optical coupling sheet 1801 also rotates with the driven wheel, and the second detection part is a notch formed on the position detection optical coupling sheet 1801, and the position of the notch on the circumference corresponds to the position of the sample tube mounting seat on the circumference, and the position detection optical coupling 1802 is arranged on the outer circumference of the position detection optical coupling sheet 1801 and is used to sense the notch.
[0055] When inserting the sample tubes 17, the mixing mechanism 2 moves intermittently to rotate each sample tube mounting seat to a preset insertion position. The relative angle between the preset insertion position and the zero position of each sample tube 17 can be determined by the position detection component. When it is necessary to take out the sample tube 17 at a certain circumferential position, the movement of the mixing mechanism 2 is controlled according to the detection result of the position detection component, so as to rotate the sample tube mounting seat under the sample tube 17 to be taken out to the preset insertion position, which can avoid the situation where the first drive motor 501 loses steps, resulting in inconsistent positions of the sample tube 17 during insertion and removal.
[0056] Furthermore, the first detection portion of the reset optical coupling piece 1601 can also be replaced by a notch set on the raised baffle. In this case, the reset optical coupling piece 1602 senses the notch on the reset optical coupling piece 1601; the second detection portion of the position detection optical coupling piece 1801 can also be replaced by a raised baffle, and the positions of each raised baffle on the position detection optical coupling piece 1801 on the circumference correspond one by one to the positions of each sample tube mounting seat on the circumference.
[0057] In one embodiment of the present invention, the reagent compartment module 100 further includes:
[0058] Optocoupler mounting seat 19, used for mounting reset optical coupler 1602 and position detection optical coupler 1802;
[0059] The second cold-isolating plate 20 is disposed below the chamber body 1 and is used to mount the optical coupler mounting seat 19 .
[0060] Similar to the setting of the first cold isolation plate 13, the setting of the second cold isolation plate 20 and the optical coupler mounting seat 19 can block the heat or cold transfer between the warehouse body 1 and the reset optical coupler 1602 and the position detection optical coupler 1802, thereby avoiding the temperature rise in the warehouse body 1, further improving the refrigeration efficiency of the first refrigeration unit 3 and the second refrigeration unit 4, and avoiding the reset optical coupler 1602 and the position detection optical coupler 1802 from being affected by the cold from the warehouse body 1 and reducing their performance.
[0061] Furthermore, in this embodiment, the second cold insulation plate 20 may be made of polyformaldehyde material. The second cold insulation plate 20 made of this material is beneficial to further improve the difficulty of transferring heat or cold between the warehouse body 1 and the reset optical coupler 1602 and the position detection optical coupler 1802.
[0062] like Figure 6 As shown, the mixing mechanism 2 includes:
[0063] The rotating disk 201 is rotatably arranged inside the bin body 1 along the horizontal direction, and a through hole is provided on the rotating disk 201;
[0064] The fixed gear 2011 is arranged below the rotating disk 201 in the horizontal direction;
[0065] The mixing module includes a plurality of mixing components arranged radially along the rotating disk 201, each mixing component includes a rotating gear 2031, a rotating shaft 2032 and a sample tube mounting seat, the rotating shaft 2032 is rotatably inserted in the through hole, the rotating gear 2031 is arranged at the bottom end of the rotating shaft 2032, two adjacent rotating gears 2031 are meshed with each other, the rotating gear 2031 at the radially innermost position is meshed with the fixed gear 2011, and the sample tube mounting seat is arranged at the top end of the rotating shaft 2032 and forms a plug-in fit with the sample tube 17.
[0066] Specifically, during the sample storage process, the sample tube 17 is inserted into the sample tube mounting seat at the top of the rotating shaft 2032 and moves with the rotating shaft 2032. The rotating disk 201 rotates under the driving action of the driving mechanism. The rotating disk 201 applies force to the rotating shaft 2032 through the peripheral wall of the through hole to drive the rotating gear 2031 in the mixing component adjacent to the fixed gear 2011 to rotate along the outer periphery of the fixed gear 2011. At the same time, the rotating gear 2031 will rotate due to the meshing with the fixed gear 2011, and at the same time, transmit power to the rotating gear 2031 close to it to drive the mixing component close to it to move, that is, each sample tube 17 and the sample inside will revolve around the center of the rotating disk 201 as the center, and will also rotate around the axis of the sample tube 17 as the center, thereby achieving mixing. The reagent bin module 100 in this embodiment has a simple structure and a compact layout inside the bin body 1, which improves the space utilization inside the bin body 1 and the storage and mixing efficiency of the reagent bin module 100, and is conducive to realizing a miniaturized design of the reagent bin module 100.
[0067] In one embodiment of the present invention, the mixing mechanism 2 further comprises a sample tube placement cylinder detachably arranged on the rotating disk 201, the sample tube placement cylinder is sleeved on the outside of the sample tube mounting seat and has a plurality of placement cavities formed therein, the plurality of placement cavities being used to respectively accommodate a plurality of sample tubes 17 at the same circumferential position. Specifically, an undercut is provided on the radially outer side of the bottom of the sample tube placement cylinder, a first connecting plate is provided on the rotating disk, and an undercut hole is provided on the first connecting plate for the above-mentioned undercut to be inserted, and the detachable connection between the sample tube placement cylinder and the rotating disk 201 can be realized through the mutual cooperation between the undercut and the undercut hole, so that the operator can put the sample tube placement cylinder into the warehouse body 1 or take it out from the warehouse body 1 according to actual needs.
[0068] In one embodiment of the present invention, the reagent chamber module 100 also includes a chamber body temperature detector 26 for detecting the temperature of the chamber body 1, an in-chamber temperature detector 27 for detecting the temperature inside the chamber body 1, and a temperature detector mounting seat 28 arranged on the circumferential wall of the chamber body 1; the temperature detector mounting seat 28 is formed with a second mounting cavity and a third mounting cavity for respectively mounting the chamber body temperature detector 26 and the in-chamber temperature detector 27.
[0069] The sample analysis device of the present invention also includes an early warning module. The early warning module, the bin temperature detector 26 and the controller are all connected in communication. The bin temperature detector 26 sends the detection result to the controller, and the controller compares the detection result with the pre-stored first preset temperature range. If the detection result is not within the first preset temperature range (such as 0°C-6°C), it means that the semiconductor refrigeration film 6 may fail. At this time, the controller controls the early warning module to send an early warning signal so that maintenance personnel can check or repair the semiconductor refrigeration film 6 as soon as possible. The in-bin temperature detector 27 sends the detection result to the controller, and the controller compares the detection result with the pre-stored second preset temperature range (such as 2°C-8°C). If the detection result is not within the second preset temperature range, it means that the semiconductor refrigeration film 6 may fail. At this time, the controller controls the early warning module to send an early warning signal so that maintenance personnel can check or repair the semiconductor refrigeration film 6 as soon as possible.
[0070] like Figures 7 to 10 As shown, the sample injection module 200 includes a mounting platform 21, a sample tray 202, a sampling track 204, a first driving mechanism, a clamping mechanism 206 and a cover opening mechanism 208; a sample conveying area 22 and a cover opening area 23 located on a lateral side of the sample conveying area 22 are provided on the mounting platform 21; the sample tray 202 is longitudinally movably arranged in the sample conveying area 22 and forms a conveying channel for a sample rack 203 for loading a sample analysis device; the sampling track 204 is transversely arranged in the cover opening area 23 and can be connected to the conveying channel; the first driving mechanism is arranged below the sampling track 204 and is used to drive the sample rack 203 to and from the conveying channel and the sampling track 204; the clamping mechanism 206 is arranged in the cover opening area 23 and is located on a longitudinal side of the sampling track 204, and is used to clamp the tube body of the sample tube 17 on the sample rack 203; the cover opening mechanism 208 is arranged in the cover opening area 23 and is located on a side of the clamping mechanism 206 away from the sampling track 204.
[0071] Specifically, when it is necessary to collect samples, the operator pushes the sample rack 203 loaded with samples into the conveying channel, and then controls the sample tray 202 to move longitudinally until the conveying channel loaded with samples is flush with the sampling track 204, and then the controller controls the first driving mechanism to drive the sample rack 203 to enter the sampling track 204 and move along the sampling track 204; further, a plurality of sample tubes 17 are placed at intervals along the horizontal direction on the sample rack 203, and the first driving mechanism intermittently moves each sample tube 17 to the sampling track 204, so as to control the cover opening mechanism 208 to open the tube covers of each of the above-mentioned sample tubes 17 one by one, and the transfer module 500 then samples the samples in each sample tube 17 one by one;
[0072] Furthermore, before performing the uncapping operation, the tube body of the sample tube 17 is pressed by the pressing mechanism 206 to prevent the tube cover from moving up and down during the uncapping process; after the tube body is pressed, the uncapping mechanism 208 performs the uncapping operation, so that the tube cover gradually separates from the tube body; after the uncapping operation is completed, the transfer module 500 of the sample analysis device can take samples from the tube body for sample analysis; after the sampling operation is completed, the uncapping mechanism 208 can re-cover the tube cover on the tube body.
[0073] The injection module 200 in this embodiment includes a mounting platform 21 and a sample tray 202, a sampling track 204, a first driving mechanism, a clamping mechanism 206 and a cover opening mechanism 208, all of which are arranged on the mounting platform 21. It has a simple structure, and the layout of each component is reasonable and compact while taking into account the smoothness of the operation process, thereby reducing the space requirement of the injection module 200 in the sample analysis device.
[0074] In one embodiment of the present invention, the injection module further comprises:
[0075] A sensing device, used for sensing the sample rack 203 entering the first conveying channel;
[0076] The second driving mechanism 213 is used to drive the sample tray 202 to move to a position where the first conveying channel is flush with the sampling track 204 .
[0077] Specifically, there are multiple first conveying channels and sensing devices, and the multiple sensing devices are arranged one by one under the multiple first conveying channels. Each first conveying channel can convey both conventional samples and emergency samples. The controller is in communication with the sensing device and the second driving mechanism 213, and can control the first driving mechanism and the second driving mechanism 213 accordingly according to the sensing signals of the sensing device. When multiple first conveying channels convey conventional samples and emergency samples at the same time, the operator first inputs the serial number of the first conveying channel where the conventional sample and the emergency sample are about to be located into the controller, and then places the sample rack 203 loaded with conventional samples and the sample rack 203 loaded with emergency samples on the first conveying channel, respectively. In the above-mentioned first conveying channels with corresponding serial numbers, each sensing device senses that the sample rack 203 loaded with routine samples and the sample rack 203 loaded with emergency samples have been placed and sends a signal to the controller. After receiving the above signal, the controller controls the movement of the sample tray 202 and makes the first conveying channel where the emergency samples are located flush with the sampling track 204, so as to preferably complete the emergency sample collection; after the emergency sample collection is completed, the first driving mechanism drives the sample rack 203 loaded with the emergency samples to return to the first conveying channel, and the second driving mechanism 213 drives the sample tray 202 to move longitudinally until the first conveying channel loaded with routine samples is flush with the sampling track 204, so as to continue to complete the routine sample collection.
[0078] In another embodiment of the present invention, the plurality of first transport channels include a conventional sample channel 209 and an emergency sample channel 210 that are longitudinally parallel and spaced apart, and the sensing device includes a conventional sample sensing element 211 and an emergency sample sensing element 212. The conventional sample sensing element 211 is used to sense the sample rack 203 entering the conventional sample channel 209, and the emergency sample sensing element 212 is used to sense the sample rack 203 entering the emergency sample channel 210. The second driving mechanism 213 responds preferentially to the emergency sample sensing element 212, and is used to drive the sample tray 202 to move to a position where the emergency sample channel 210 is flush with the sampling track 204.
[0079] Specifically, the conventional sample channel 209 and the emergency sample channel 210 are both connected in the transverse direction, the conventional sample sensing element 211 is arranged at the entrance of the conventional sample channel 209 , and the emergency sample sensing element 212 is arranged at the entrance of the emergency sample channel 210 .
[0080] When only conventional samples need to be sampled, the operator pushes the sample rack 203 loaded with conventional samples into the conventional sample channel 209, and the conventional sample sensing element 211 can sense the sample rack 203 loaded with conventional samples and send a corresponding sensing signal to the controller. After receiving the sensing signal, the controller controls the second driving mechanism 213 to drive the sample tray 202 to move longitudinally until the conventional sample channel 209 loaded with conventional samples is aligned with the sampling track 204, and then the controller controls the first driving mechanism to drive the sample rack 203 to move along the sampling track 204;
[0081] If there is a sample rack 203 loaded with conventional samples on the sampling track 204, and the tube covers of the sample tubes 17 on the sample rack 203 are all covered on the tube bodies, the operator pushes the sample rack 203 loaded with emergency samples into the emergency sample channel 210, and the emergency sample sensor 212 can sense the sample rack 203 loaded with emergency samples and send a corresponding sensing signal to the controller. After receiving the sensing signal, the controller first controls the first driving mechanism to return the sample rack 203 loaded with conventional samples to the conventional sample channel 209, and then controls the second driving mechanism 213 to drive the sample tray 210. 02 moves longitudinally until the emergency sample channel 210 loaded with the emergency sample is aligned with the sampling track 204, and then the sample rack 203 loaded with the emergency sample is driven by the first driving mechanism to move along the sampling track 204, so as to preferably complete the emergency sample collection; after the emergency sample collection is completed, the first driving mechanism drives the sample rack 203 loaded with the emergency sample to return to the emergency sample channel 210, and the second driving mechanism 213 drives the sample tray 202 to move longitudinally until the conventional sample channel 209 loaded with the conventional sample is aligned with the sampling track 204, so as to continue to complete the conventional sample collection.
[0082] Furthermore, if there is a sample rack 203 loaded with conventional samples on the sampling track 204, but the tube cover of the sample tube 17 on the sample rack 203 is opened, the operator pushes the sample rack 203 loaded with emergency samples into the emergency sample channel 210, and the emergency sample sensor 212 can sense the sample rack 203 loaded with emergency samples and send a corresponding sensing signal to the controller. After receiving the sensing signal, the controller controls the opening cover mechanism 208 and the transfer module 500 to continue to complete the opening cover operation and sampling operation corresponding to the sample tube 17 with the tube cover opened, so that the opening cover mechanism 208 and the transfer module 500 can be avoided from performing a secondary opening cover operation and sampling operation on the sample tube 17 during the subsequent conventional sample collection process, and can also avoid the sample tube 17 being in an open state for multiple times to cause sample contamination; the opening cover corresponding to the sample tube 17 After the operation and sampling operation are completed, the controller controls the first driving mechanism to return the sample rack 203 loaded with conventional samples to the conventional sample channel 209, and then controls the second driving mechanism 213 to drive the sample tray 202 to move longitudinally until the emergency sample channel 210 loaded with emergency samples is flush with the sampling track 204, and then the controller controls the first driving mechanism to drive the sample rack 203 loaded with emergency samples to enter the sampling track 204 and move along the sampling track 204, so as to preferentially complete the emergency sample collection; after the emergency sample collection is completed, the first driving mechanism drives the sample rack 203 loaded with emergency samples to return to the emergency sample channel 210, and the second driving mechanism 213 drives the sample tray 202 to move longitudinally until the conventional sample channel 209 loaded with conventional samples is flush with the sampling track 204, so as to continue to complete the conventional sample collection. Compared with the prior art, the sampling module 200 integrates the conventional sample sampling and the emergency sample sampling without increasing the overall occupied space, which is conducive to the priority sampling and collection of emergency samples.
[0083] Specifically, the conventional sample sensing element 211 also includes a first action reed arranged below the first sensing part and connected to the first sensing part, and the emergency sample sensing element 212 also includes a second action reed arranged below the second sensing part and connected to the first sensing part, wherein the first sensing part and the second sensing part can also be selected as light sensing sensors.
[0084] In one embodiment of the present invention, a first hook portion 223 is formed at one end of the sample rack 203, strip holes distributed in the transverse direction are formed on the sampling track 204, and the first driving mechanism includes:
[0085] The lead screw motor 222 is disposed below the sampling track 204 in the transverse direction;
[0086] A first connection block is disposed on the screw portion of the screw motor 222 and is threadedly connected to the screw portion;
[0087] The handle is arranged on the screw rod part and connected to the first connecting block. The handle is formed with a second hooking part which passes through a strip hole upward and is used to hook the first hooking part 223 .
[0088] Specifically, the first hook-pull portion 223 is arranged at the lower end of the side end surface of the sample rack 203. When the operator pushes the sample rack 203 into the conventional sample channel 209 or the emergency sample channel 210, the first hook-pull portion 223 is at the end of the sample rack 203 close to the sampling track 204, and the second hook-pull portion can subsequently hook the first hook-pull portion 223; the sampling track 204 is arranged vertically at intervals above the mounting platform 21, and the screw motor 222 is communicatively connected with the controller. The screw motor 222 is arranged below the sampling track 204 and at the end of the sampling track 204 away from the sampling area. When the screw motor 222 rotates forward, the first connecting block drives the handle to move along the axial direction of the screw portion. When the first connecting block moves to the first preset position, the second hook-pull portion on the handle can hook the first hook-pull portion 223 of the sample rack 203, and then the screw motor 222 is controlled to rotate in the opposite direction, and the first connecting block moves in the opposite direction along the screw portion with the handle, and at the same time, the second hook-pull portion can pull the sample rack 203 from the conventional sample track or the emergency sample track into the sampling track 204 and move along the sampling track 204; after the sample collection is completed, the screw motor 222 is controlled to rotate forward, and the first connecting block moves along the screw portion with the handle toward the direction of the sampling area, and at the same time, the second hook-pull portion can push the sample rack 203 from the sampling track 204 back to the conventional sample track or the emergency sample track.
[0089] In one embodiment of the present invention, the sample injection module 200 further includes a first in-place detection baffle and a first in-place detector; the first in-place detection baffle is connected to the first connection block; the first in-place detector is disposed below the sampling track 204 and is used to detect the in-place of the first in-place detection baffle. Specifically, the first in-place detection baffle can be an optical coupling sheet, and the first in-place detector is connected to the controller in communication and can be an optical coupling detector.
[0090] In an embodiment of the present invention, the second driving mechanism 213 includes a second driving motor, a first transmission assembly 2131, a threaded rod 2132, and a third connecting block; the second driving motor is longitudinally arranged in the opening area 23; the first driving end of the first transmission assembly 2131 is drivingly connected to the second driving motor; the threaded rod 2132 is longitudinally arranged in the sample conveying area 22 and is connected to the second driving end of the first transmission assembly 2131; the third connecting block is movably arranged on the threaded rod 2132 and is connected to the sample tray 202. Specifically, the first transmission assembly 2131 includes a first driving wheel, a first driven wheel, and a first transmission belt. The first driving wheel is drivingly connected to the second driving motor, the first driven wheel is connected to the threaded rod 2132, and the first transmission belt is sleeved outside the first driving wheel and the first driven wheel. When the second driving motor rotates, it can drive the first transmission assembly 2131 and the threaded rod 2132 to rotate in sequence, and the third connecting block can move axially along the threaded rod 2132, thereby realizing the adjustment of the longitudinal position of the sample tray 202.
[0091] In an embodiment of the present invention, the sampling module 200 further includes a second in-place detection flap 216 and a second in-place detector 217; the second in-place detection flap 216 is connected to the sample tray 202; the second in-place detector 217 is arranged on the mounting platform 21 and is used for in-place detection of the second in-place detection flap 216.
[0092] Specifically, the second in-place detection flap 216 can be selected as an optocoupler chip, the second in-place detector 217 is communicatively connected to the controller and can be selected as an optocoupler detector. When the second driving motor of the second driving mechanism 213 rotates, the second in-place detection flap 216 moves longitudinally with the sample tray 202. When the sample tray 202 moves to the second preset position, the second in-place detector 217 detects the second in-place detection flap 216, and this position can be set as the position origin of the sample tray 202. The second in-place detection flap 216, the second in-place detector 217, and the second driving motor cooperate to enable the controller to determine and adjust the longitudinal position of the sample tray 202.
[0093] In an embodiment of the present invention, the pressing mechanism 206 includes a pressing driving assembly 2061, a pressing wheel assembly 2062, and a pressing seat 2063. The pressing driving assembly 2061 is vertically arranged on the mounting platform 21 in the opening area 23, the pressing wheel assembly 2062 is arranged on the pressing driving assembly 2061 and can move up and down vertically. A vertical groove is formed on the sample rack 203 facing the pressing mechanism 206, and the pressing seat 2063 is rotatably arranged on the pressing driving assembly 2061 and is used to pass through the vertical groove to press the tube body. A guiding inclined surface that gradually inclines upward from bottom to top and is used to guide the pressing wheel of the pressing wheel assembly 2062 is formed on the side wall of the pressing seat 2063 away from the sample rack 203.
[0094] Specifically, the clamping drive assembly 2061 includes a clamping mounting seat and a clamping drive member, wherein the clamping mounting seat is arranged on the mounting platform 21, and the clamping drive member is arranged below the mounting platform 21 and has a driving shaft 503 that passes through the mounting platform 21 and the clamping mounting seat in sequence upward. In this embodiment, the clamping drive member can be selected as a through-axis motor; the pressure wheel assembly 2062 includes a first guide rail 2064, a first slider 2065 and a pressure wheel, wherein the first guide rail 2064 is vertically arranged on the clamping mounting seat; the first slider 2065 is arranged on the first guide rail 2064 and is drivingly connected to the clamping drive member, and a laterally protruding pressure wheel mounting portion is also formed on the first slider 2065, and the screw rod of the through-axis motor passes upward through the mounting platform 21, the bottom wall of the clamping mounting seat and forms a threaded connection with the first slider 2065; the pressure wheel is rotatably arranged on the pressure wheel mounting portion and can roll up and down along the guide inclined surface on the clamping seat 2063.
[0095] Before the body of the sample tube 17 is compressed, the first slider 2065 is at the second preset height, at which time the pressure wheel is at the bottom of the guide slope, and the pressure seat 2063 does not apply a pressure to the tube body; when the body of the sample tube 17 needs to be compressed, the through-axis motor rotates and drives the first slider 2065 to move upward along the first guide rail 2064, and the pressure wheel moves upward along the guide slope. During the upward movement of the pressure wheel, pressure is gradually applied to the pressure seat 2063, causing the pressure seat 2063 to deflect in the direction of the sample tube 17, thereby causing the top of the pressure seat 2063 to gradually apply a pressure to the tube body; when the first slider 2065 rises to the third preset height, the pressure seat 2063 completely compresses the tube body, preventing the tube body from moving upward when the opening mechanism 208 applies an upward force to the tube cover, thereby ensuring the reliability of the opening operation; multiple components in the clamping mechanism 206 are vertically distributed, so that it has the advantages of compact structure and small space occupation.
[0096] In one embodiment of the present invention, the injection module 200 further includes a third in-place detection baffle connected to the clamping seat 2063 and a third in-place detector disposed on the clamping mounting seat; the third in-place detector is used to perform in-place detection on the third in-place detection baffle.
[0097] Specifically, the third in-place detection baffle can be selected as an optical coupling piece, and the third in-place detector is communicatively connected to the controller and can be selected as an optical coupling detector. When the clamping seat 2063 is not deflected, the third in-place detector detects the third in-place detection baffle, and this position can be set as the position origin of the clamping seat 2063; when the clamping seat 2063 is deflected, the third in-place detection baffle deflects along with the clamping seat 2063. When the clamping seat 2063 is deflected into place, the third in-place detector cannot detect the third in-place detection baffle, indicating that the clamping seat 2063 has clamped the tube body. The cooperation between the third in-place detection baffle and the third in-place detector facilitates the controller to determine whether the tube body is in a clamped state.
[0098] In one embodiment of the present invention, Fig. 9 As shown, the injection module 200 also includes a lifting mechanism 220 and a connecting arm 221. The lifting mechanism 220 can be lifted and lowered on the mounting platform 21 and is located on the side of the clamping mechanism 206 away from the sample rack 203. The connecting arm 221 is arranged on the top of the lifting mechanism 220; the cover opening mechanism 208 includes a cover opening drive member 2081, a pivot shaft 2082, and two clamping members 2083. The pivot shaft 2082 is vertically arranged on the connecting arm 221. The two clamping members 2083 both include a connecting portion and a clamping portion. The upper end of the clamping portion is connected to the connecting portion and can clamp the tube cover of the sample tube 17 from the upper and lower ends. The connecting portion can be rotatably arranged on the pivot shaft 2082 in the horizontal direction. A clamping space for clamping the tube cover is formed between the clamping portions of the two clamping members 2083. The cover opening drive member 2081 is horizontally arranged above the connecting arm 221 and is used to drive the clamping portions of the two clamping members 2083 to approach or move away from each other.
[0099] Before the uncapping operation is performed, the tube body of the sample tube 17 is pressed by the pressing mechanism 206, the two clamping members 2083 are in an open state, the tube cover is in the clamping space, and the lifting mechanism 220 is at a first preset height so that the upper clamping portion and the lower clamping portion can clamp the top surface and the bottom surface of the tube cover respectively later; when the uncapping operation is performed, the uncapping driving member 2081 drives the connecting parts of the two clamping members 2083 to rotate around the pivot shaft 2082 and the angle between the two is gradually reduced, and the clamping parts of the two clamping members 2083 approach each other until the clamping of the two clamping members 2083 The holding portion can clamp the tube cover from the circumferential direction, and then the cover opening driving member 2081 stops driving and the lifting mechanism 220 performs the ascending operation, and the lower clamping portion applies an upward force to the bottom surface of the tube cover, so that the tube cover gradually separates from the tube body to complete the cover opening operation; after the sampling operation is completed, the cover opening mechanism 208 can perform the cover operation, that is, the lifting mechanism 220 descends to make the tube cover re-cover the tube body, and after the inner circumferential wall of the tube cover contacts the outer circumferential wall of the tube body, the upper clamping portion applies a downward force to the top surface of the tube cover, so that the tube cover continues to descend so as to be completely covered on the tube body.
[0100] In one embodiment of the present invention, a first oblique groove and a second oblique groove are respectively provided on the connecting parts of the two clamping members 2083, and the first oblique groove and the second oblique groove are distributed outwardly. The cover opening mechanism 208 also includes a second connecting block driven and connected to the telescopic end of the cover opening driving member 2081, and the bottom of the second connecting block is formed with a first connecting column and a second connecting column for inserting into the first oblique groove and the second oblique groove respectively.
[0101] Specifically, the cover opening drive member 2081 in this embodiment can be selected as a telescopic motor. When the telescopic end of the telescopic motor is extended, it drives the second connecting block to move in the direction away from the telescopic motor, and the first connecting column and the second connecting column move from the first end of the first inclined groove and the second inclined groove (that is, the end close to the telescopic motor) to the second end (that is, the end away from the telescopic motor), driving the connecting parts of the two clamping members 2083 to rotate around the pivot shaft 2082, and making the two clamping parts respectively connected to the above-mentioned two connecting parts approach each other so that the two clamping members 2083 clamp the tube cover; conversely, the two clamping parts respectively connected to the above-mentioned two connecting parts can be made to move away from each other so that the two clamping members 2083 loosen the tube cover.
[0102] like Figures 11 to 13As shown in the figure, the reaction cup sorting module 300 of the present application includes a reaction cup loading bin 301 for holding a plurality of reaction cups 700, a reaction cup sorting drum 302, a baffle 305, a first rotation driving assembly 306, and a cup pushing mechanism; a plurality of partition portions 304 are spaced apart on the inner peripheral wall of the reaction cup sorting drum 302, and the plurality of partition portions 304 are arranged obliquely relative to the inner peripheral wall of the reaction cup sorting drum 302. A guiding channel 303 is formed between any two adjacent partition portions 304, and the feeding end of the guiding channel 303 is communicated with the discharging end of the reaction cup loading bin 301; the baffle 305 is located on the side of the reaction cup sorting drum 302 away from the reaction cup loading bin 301, and a cup discharging opening 308 for discharging the reaction cup 700 is formed on the baffle 305; the first rotation driving assembly 306 is used to drive the reaction cup sorting drum 302 to rotate, so as to drive the discharging end of each guiding channel 303 to rotate to a position communicated with the cup discharging opening 308 in sequence; the cup pushing mechanism includes a conveying assembly and a cup pushing assembly 307. The conveying assembly forms a cup dropping opening 315 and a second conveying channel 309 communicated with the cup discharging opening 308, and the cup pushing assembly 307 is used to push the reaction cups 700 in the second conveying channel 309 to the cup dropping opening 315 in sequence. During the reaction cup sorting operation, a plurality of reaction cups 700 in the reaction cup loading bin 301 enter the reaction cup sorting drum 302, and the first rotation driving assembly 306 drives the reaction cup sorting drum 302 to rotate. Thus, under the action of the centrifugal force during rotation, each reaction cup 700 will flow into the guiding channel 303. As the rotation progresses, when any one of the guiding channels 303 is aligned with the cup discharging opening 308, since the extension lines of the side walls of the opposite surfaces of the two partition portions 304 and the extension line of the inner peripheral wall of the reaction cup sorting drum 302 are both arranged to intersect in the direction of the cup discharging opening 308, the reaction cup 700 in the guiding channel 303 will be thrown out from the cup discharging opening 308 and enter the second conveying channel 309; under the action of gravity, the reaction cup 700 drops vertically, and then the cup pushing assembly 307 pushes the reaction cup 700 in the second conveying channel 309 to the cup dropping opening 315 and drops it into the reaction tray 404 to start the next process. By improving the structure of the inner peripheral wall of the reaction cup sorting drum 302 and cooperating with the cup dropping and cup pushing functions of the second conveying channel 309 and the cup pushing assembly 307, the present application enables the disordered reaction cups 700 to vertically fall into the second conveying channel 309 in sequence under the combined action of the first rotation driving assembly 306 and gravity, without the occurrence of cup jamming.
[0103] In one embodiment, a plurality of guide channels 303 are sequentially arranged along the circumference of the cup-arranging drum 302, and the opposing surfaces of the two partition sections 304 of the same guide channel 303 are arranged relatively inclined to the inner peripheral wall of the cup-arranging drum 302. The present application improves the angle of the inner peripheral wall of the guide channel 303, and the inner side walls of the two partition sections 304 can prevent the reaction cups 700 in the guide channel 303 from flying out, so that the reaction cups 700 in each guide channel 303 are always kept inside, until the discharge end of the guide channel 303 is connected to the cup outlet 308, and then the reaction cups 700 in the guide channel 303 connected to the cup outlet 308 are driven to be thrown out from the cup outlet 308.
[0104] In one embodiment, the second conveying channel 309 includes a vertical channel, a V-shaped groove channel and a cup drop channel 313 which are connected in sequence from top to bottom. The large end of the V-shaped groove channel opens toward the vertical channel, the small end of the V-shaped groove channel is connected to the cup drop channel 313, and one end of the cup drop channel 313 is connected to the cup drop opening 315. The cup drop channel 313 is a long guide hole which runs through from top to bottom. The upper end of the cup drop channel 313 is connected to the V-shaped groove channel, and the lower end is open. In this way, the reaction cup 700 which falls into the cup drop channel 313 can fall vertically into the cup drop channel 313 under the action of gravity, and the bottom of the reaction cup 700 can extend from the bottom of the cup drop channel 313. Since a circle of clamping rings are provided on the outer peripheral wall of the reaction cup 700, the clamping rings can be clamped on the top of the cup drop channel 313 during the process of the reaction cup 700 falling, so as to prevent the entire reaction cup 700 from sliding off from the bottom of the cup drop channel 313. In addition, the cup drop channel 313 is extended in the front-to-back direction, so that the dropped reaction cup 700 can move toward the cup drop port 315 under the push of the cup pusher assembly 307, and the multiple reaction cups 700 that have not fallen out of the cup drop port 315 are arranged in sequence front to back along the extension direction of the cup drop channel 313 to prevent the reaction cup 700 from being horizontally placed, thereby ensuring that each reaction cup 700 can pass through the cup drop port 315 in sequence, thereby avoiding cup jamming or confusion.
[0105] In one embodiment, the cup unscrambling module 300 further includes a baffle 305, which is closed on the side of the cup unscrambling drum 302 away from the reaction cup loading bin 301, and a cup outlet 308 is provided on the baffle 305. The cup outlet 308 is provided with an inclined guide plate extending into the vertical channel. Preferably, the inclined angle of the inclined guide plate is set to 45°. With this design, the reaction cups 700 sliding out of the cup outlet 308 can fall into the vertical channel in sequence at an inclined angle of 45° under the inclined guiding action of the inclined guide plate.
[0106] In one embodiment, the conveying assembly includes a conveying guide block 310 and two inclined plates 311; a cup drop channel 313 for sequentially arranging reaction cups 700 is provided inside the conveying guide block 310 along a first direction, a cup drop bucket 314 connected to the cup drop channel 313 is provided below the end of the conveying guide block 310, and a cup drop opening 315 is provided at the bottom of the cup drop bucket 314;
[0107] Two inclined plates 311 are mounted on the conveying guide block 310 and are symmetrically arranged on both sides of the top of the cup drop channel 313, and a V-shaped groove channel connected to the cup drop channel 313 is formed between the two inclined plates 311. The reaction cup 700 that falls from the cup outlet 308 into the vertical channel at an inclined angle of 45° gradually changes into a vertical falling motion under the action of gravity; and in order to enable the reaction cup 700 to maintain a vertical posture and fall into the cup drop channel 313, a V-shaped groove channel with a guiding function on both sides is provided between the cup drop channel 313 and the vertical channel, thereby ensuring that all reaction cups 700 can fall vertically.
[0108] In order to prevent the cuvette 700 in the cup drop channel 313 from falling, and the cuvette 700 pushed into the cup drop bucket 314 needs to fall from the cup drop opening 315 at the bottom, the inner diameter of the cup drop bucket 314 needs to be designed to be larger than the width of the cup drop channel 313, so that the cuvette 700 pushed from the cup drop channel 313 can smoothly fall from the cup drop opening 315 of the cup drop bucket 314. In addition, in order to ensure the orderly drop of the cups, the inner diameter of the cup drop bucket 314 is set to a size that can only accommodate one cuvette 700, so that multiple cuvettes 700 can fall in sequence and smoothly, and there will be no confusion of multiple cuvettes 700 falling at the same time.
[0109] like Fig.13 As shown, the cup pusher assembly 307 includes a pusher 3071, a guide rail 3072, a second linear drive member 3074 and a first linear drive member 3073; the guide rail 3072 is installed on the outer wall of the conveying guide block 310 along a first direction; the second linear drive member 3074 is used to drive the pusher 3071 to approach or move away from the reaction cup 700 in the cup drop channel 313 along a second direction, and the first direction and the second direction intersect; the first linear drive member 3073 is installed on the guide rail 3072 to drive the second linear drive member 3074 to move linearly along the first direction.
[0110] The first linear drive member 3073 and the second linear drive member 3074 both adopt a conventional linear drive structure of a drive motor and a rotating screw. Fig.13 The front-to-back direction in the second direction is Fig.13The first linear drive member 3073 has a spiral sleeve on the rotating screw rod, one side of the slider is in sliding contact with the guide rail 3072, and the other side of the slider is connected to the second linear drive member 3074. When the rotating screw rod of the first linear drive member 3073 rotates, it can drive the slider to slide along the guide rail 3072.
[0111] When the cup is pushed, the second linear drive member 3074 drives the pushing member 3071 to move to the left to contact the reaction cup 700, and then the first linear drive member 3073 drives the second linear drive member 3074 to move in the front-to-back direction to push the reaction cup 700 toward the cup drop opening 315. When the reaction cup 700 reaches the cup drop opening 315, the cup is dropped. In this reciprocating manner, the multiple reaction cups 700 in the cup drop channel 313 are dropped in sequence to prevent the cup from getting stuck during the cup sorting process.
[0112] In one embodiment, the cup sorting module 300 further includes a judgment element, which is a judgment optical coupler 312. The judgment optical coupler 312 is arranged near the cup drop port 315 and is used to judge whether there is a reaction cup 700 dropped at the cup drop port 315. The cup sorting module 300 also includes a control unit electrically connected to the judgment optical coupler 312. When the judgment optical coupler 312 recognizes that there is a reaction cup 700 waiting to drop at the cup drop port 315, the control unit controls the cup pusher assembly 307 to stop the cup push action for the next reaction cup 700; when the judgment optical coupler 312 recognizes that there is no reaction cup 700 at the cup drop port 315, the control unit controls the cup pusher assembly 307 to push the next reaction cup 700 to the cup drop port 315 to wait for it to drop. This method can make the reaction cup 700 drop efficiently and smoothly from the cup drop port 315 without causing disorder.
[0113] In one embodiment, the first rotation drive assembly 306 includes a large synchronous wheel, a small synchronous wheel, a synchronous belt wound around the large synchronous wheel and the small synchronous wheel, and a fourth rotation drive member coaxially connected to the small synchronous wheel, and the large synchronous wheel is installed on the side of the cup unscrambling drum 302 facing the reaction cup loading bin 301. Among them, the fourth rotation drive member is preferably a servo motor; the servo motor rotates to drive the small synchronous wheel to rotate, thereby driving the synchronous rotation of the large synchronous wheel; because the large synchronous wheel is installed on the outer periphery of the cup unscrambling drum 302, when the large synchronous wheel rotates, it can drive the entire cup unscrambling drum 302 to rotate radially at the same time.
[0114] like Figures 14 to 17As shown, the present invention provides an incubation module 400, including an incubation tray, a stirring assembly 401, a second rotation drive assembly 402, an optical coupling assembly and a control unit; the incubation tray includes a rotating tray 403 and a reaction tray 404, the rotating tray 403 is provided with a plurality of through holes 405 for accommodating reaction cups 700 along the circumferential direction, and a reaction cup accommodating station 406 for inserting the bottom of the reaction cup 700 is formed on the reaction tray 404, and the reaction tray 404 is used to incubate and heat the reaction cup 700; the stirring assembly 401 is installed on the reaction tray 4 04 and is used to stir and mix the reagents and samples in the reaction cup 700; the second rotation drive component 402 is used to drive the rotating disk 403 to rotate; the optical coupling component is arranged on the reaction disk 404 and obtains the corresponding position information of the through hole 405 and the reaction cup receiving station 406 and sends out a judgment signal; the control unit is electrically connected to the optical coupling component and controls the action of the second rotation drive component 402 according to the received judgment signal, so that the through hole 405 and the reaction cup receiving station 406 correspond one by one with the rotation of the rotating disk 403.
[0115] The incubation tray of the present application can ensure that all reaction cups 700 are fully incubated at the incubation temperature, and only the reaction cups 700 that need reagent mixing are effectively mixed, without affecting other reaction cups 700, and there are no redundant components. The entire incubation tray has a streamlined structure, runs smoothly and reliably, and fully incubates the reaction cups 700. In addition, multiple components are integrated on the incubation tray, which improves the modular production and sample analysis of the entire incubation module 400.
[0116] In one embodiment, a mounting plate is further provided below the reaction plate 404, and the stirring assembly 40 is located on the mounting plate. The stirring assembly 401 includes a first rotating driving member 4011, a stirring adapter shaft 4012, and a stirring oscillation shaft 4013; the top of the stirring adapter shaft 4012 forms a stirring groove for the bottom of the reaction cup 700 to be inserted, and the stirring groove is a cylindrical eccentric structure; the bottom of the stirring oscillation shaft 4013 is drivingly connected to the first rotating driving member 4011, and the top of the stirring oscillation shaft 4013 is connected to the stirring adapter shaft 4012. When one of the reaction cups 700 needs to be mixed, the second rotating driving member 402 drives the rotating plate 403 to rotate, so that the reaction cup 700 rotates to a position where it is connected to the stirring adapter shaft 4012, and at this time, the first rotating driving member 4011 drives the stirring oscillation shaft 4013 to rotate and oscillate, thereby realizing the rotation of the reaction cup 700. Among them, since the stirring tank is an eccentric structure, when the stirring adapter shaft 4012 drives the reaction cup 700 to rotate, the mixing effect of the reaction cup 700 can be improved.
[0117] In one embodiment, the rotating disk 403 includes a rotating ring 4031 coaxially arranged at intervals on the inner circumference of the reaction disk 404 and a rotating cover plate 4032 covering the rotating ring 4031. The outer peripheral wall of the rotating ring 4031 has external gear teeth. The second rotating drive assembly 402 includes a second rotating drive member located between the rotating ring 4031 and the reaction disk 404 and a gear coaxially connected to the second rotating drive member. The rotating cover plate 4032 is connected to the rotating ring 4031 and is located above the reaction disk 404. In order to realize the rotation of the rotating ring 4031, gear teeth are formed on the outer circumference of the rotating ring 4031. The second rotating drive assembly 402 can be a rotating motor plus a gear matching structure. The gear is meshed with the outer circumference of the rotating ring 4031, so that the rotating motor can drive the gear and the rotating ring 4031 to rotate.
[0118] In one embodiment, the incubation module 400 also includes a mounting table 407, a cleaning and injection assembly 408, and a lifting and driving assembly 409; the number of the cleaning and injection assemblies 408 is at least two groups and they are arranged on the mounting table 407 along an arc interval. In the rotation direction of the rotating cover 4032, the cleaning and injection assembly 408 located at the last position is used to absorb the remaining liquid in the reaction cup 700, and the remaining cleaning and injection assemblies 408 are used to absorb the liquid in the reaction cup 700 and inject cleaning liquid; the lifting and driving assembly 409 is installed on the reaction disk 404 and is used to lift and lower the mounting table 407 to drive the cleaning and injection assembly 408 away from or insert into the reaction cup 700.
[0119] During the cleaning process, the rotating disk 403 is driven to rotate. When the multiple reaction cup receiving stations 406 rotate to the bottom of the cleaning and injection components 408, the lifting drive component 409 drives the cleaning and injection components 408 to descend and insert into the reaction cups 700 accordingly. Each reaction cup 700 needs to undergo multi-stage cleaning by multiple groups of cleaning and injection components 408. In the rotation direction of the rotating disk 403, the multiple groups of cleaning and injection components 408 located in the front first suck away the liquid in the reaction cup 700 during each cleaning process, and then inject the cleaning liquid for cleaning; when the reaction cup 700 rotates to the cleaning and injection component 408 located at the end, it needs to suck away all the remaining liquid in the reaction cup 700. In this way, the cooperation of multiple groups of cleaning and injection components 408 can complete the multi-stage cleaning of a reaction cup 700, ensuring the cleaning effect. In addition, the entire cleaning process has a high degree of automation, which is conducive to modular production. Furthermore, since the multiple cleaning and injection components 408 are arranged on the mounting platform 407 along an arc at intervals, in order to improve the cleaning efficiency, the orthographic projections of the multiple cleaning and injection components 408 are all located on the circumference of the multiple reaction cup receiving stations 406.
[0120] In one embodiment, the cleaning and liquid injection assembly 408 includes a guide sleeve and a reaction needle integrated in the guide sleeve; the guide sleeve movably passes through the mounting platform 407; the reaction needle is used to absorb the liquid in the reaction cup 700 or inject the cleaning liquid into the reaction cup 700. Among them, along the rotation direction of the rotating disk 403, the reaction needle located at the last position includes a suction needle 4081 for absorbing the liquid in the reaction cup 700, and the remaining reaction needles include an injection needle 4082 for injecting the cleaning liquid into the reaction cup 700 and a suction needle 4081 for absorbing the liquid in the reaction cup 700. Among them, the upper end of the suction needle 4081 is externally connected to a suction power device to provide suction power for the suction needle 4081 to absorb the liquid; the upper end of the injection needle 4082 is externally connected to a container containing the cleaning liquid and a driving device, and the driving device pumps the cleaning liquid into the injection needle 4082 to inject the cleaning liquid into the reaction cup 700.
[0121] In a preferred embodiment, Fig.16 As shown, there are five groups of cleaning and injection components 408. When the rotating disk 403 rotates clockwise, the reaction needles in the cleaning and injection components 408 located in the front four positions along the rotation direction of the rotating disk 403 all include a suction needle 4081 and an injection needle 4082; at the front four stations, the suction needle 4081 is used to suck away the liquid in the corresponding reaction cup 700, and then the injection needle 4082 is used to inject new cleaning liquid into the reaction cup 700 to clean the residual solvent in the reaction cup 700; the cleaning and injection component 408 located in the last position includes a suction needle 4081, which is used to suck away all the remaining liquid in the reaction cup 700. Since the suction needle 4081 needs to suck the liquid in the reaction cup 700, and the injection needle 4082 only needs to inject cleaning liquid into the reaction cup 700, the plane where the bottom of the suction needle 4081 is located needs to be higher than the plane where the bottom of the injection needle 4082 is located. This can ensure that the suction needle 4081 can contact the bottom of the reaction cup 700 and completely absorb the liquid in the reaction cup 700 when it descends to a certain height.
[0122] In one embodiment, the cleaning and injection assembly 408 also includes a mounting block 4083, a guide column 4084 and an elastic member 4085; the mounting block 4083 is attached to the mounting platform 407, and a mounting hole for the guide sleeve to pass through is opened on the mounting block 4083; the guide column 4084 is installed on the mounting platform 407 and movably passes through the mounting block 4083, and is arranged with the guide sleeve in the rotation direction of the reaction disk 404 at intervals, and a convex ring is formed on the top of the guide column 4084; the elastic member 4085 is arranged around the outer circumference of the guide column 4084, and the elastic member 4085 is elastically compressed between the convex ring and the mounting block 4083, so the elastic member 4085 always applies an elastic force to the mounting block 4083 to ensure that the mounting block 4083 and the mounting platform 407 are always in contact. When the lifting drive assembly 409 drives the mounting platform 407 to move upward, the elastic member 4085 applies a downward elastic force to the mounting block 4083, so that the mounting block 4083 can fit the mounting platform 407 and move upward with the mounting platform 407; and the mounting platform 407 and the guide sleeve are integrally formed, so the rise of the mounting platform 407 can drive the guide sleeve and the reaction needle to move upward together until they are separated from the reaction cup 700. When the lifting drive assembly 409 drives the mounting platform 407 to move downward, the mounting platform 407 moves downward together with the guide sleeve until the reaction needle is inserted into the reaction cup 700. It should be pointed out that when the suction needle 4081 moves downward and contacts the bottom of the reaction cup 700, the setting of the elastic member 4085 can play a certain buffering role in the downward movement process, preventing the bottom end of the suction needle 4081 from being damaged.
[0123] In one embodiment, the lifting drive assembly 409 includes a rotating screw, a third rotating drive member, a slide rail and a connecting block; a rotating nut is spirally sleeved on the rotating screw; the third rotating drive member is used to drive the rotating screw to rotate, wherein the third rotating drive member is a screw drive motor, the driving end of the screw drive motor is connected to the rotating screw and is used to drive the rotating screw to rotate; the slide rail is connected to the rotating nut, and the top of the slide rail is detachably connected to the mounting table 407; the connecting block slides with the slide rail along the height direction. When the lifting drive is required, the screw drive motor rotates to drive the rotating screw to rotate, so that the rotating nut spirally sleeved on the rotating screw can move up and down relative to the rotating screw, and the slide rail connected to the rotating nut also moves up and down with the rotating nut, thereby driving the mounting table 407 to move. Since the side of the slide rail away from the rotating nut slides with the connecting block, the slide rail drives the cleaning and injection assembly 408 to move up and down relative to the entire reaction disk 404, so as to achieve the purpose of the cleaning and injection assembly 408 being away from or inserted into the reaction cup 700.
[0124] In one embodiment, a magnetic attraction piece is provided on the outer peripheral wall of the reaction disk 404, and a plurality of magnetic attraction pieces are arranged corresponding to the positions of the cleaning and liquid injection components 408, and the magnetic attraction piece can be magnetically attracted to the magnetic beads in the reaction cup 700. When the rotating disk 403 rotates, the reaction cups 700 located at the front four reaction cup receiving stations 406 correspond to a magnetic attraction piece respectively, and when the rotating disk 403 stops rotating, the magnetic attraction piece attracts the magnetic beads in the corresponding reaction cup 700, so that the magnetic beads in the reaction cup 700 are attracted to the inner wall of the reaction cup 700. When the suction needle 4081 of the cleaning and injection component 408 absorbs the liquid in the reaction cup 700, the presence of the magnetic beads does not affect the adsorption of the suction needle 4081, and the magnetic beads adsorbed to the inner wall by the magnetic suction component will not enter the suction needle 4081; after the liquid is absorbed, the injection needle 4082 flushes the reaction cup 700. On the one hand, the cleaning liquid can be used to flush the magnetic beads on the inner wall of the reaction cup 700, and the magnetic beads are dispersed in the reaction cup 700 without gathering, so that the residual reagent on the magnetic beads is also flushed into the reaction cup 700; on the other hand, the injection needle 4082 can flush the outer wall of the suction needle 4081, thereby flushing the reagent stuck on the outer wall of the suction needle 4081 into the reaction cup 700. The reaction cup 700 that has completed the previous flushing process moves to the bottom of the next cleaning and injection component 408 driven by the rotation of the rotating disk 403 to prepare for secondary cleaning. After multiple cleanings, when the reaction cup 700 moves to the bottom of the cleaning and injection component 408 located at the last position, the suction needle 4081 sucks away all the remaining liquid in the reaction cup 700, thereby completing the multiple cleaning process of a reaction cup 700.
[0125] In one embodiment, the optical coupling assembly includes a position matching member and a position optical coupling member 411; the number of the position matching members is multiple, and the multiple position matching members are arranged on the rotating disk 403 along the circumferential direction and correspond to the reaction cup receiving station 406 one by one; the position optical coupling member 411 cooperates with the position matching member and obtains the position information of the reaction cup receiving station 406, and sends a judgment signal according to the position information. Among them, an annular groove is opened on the reaction disk 404 along the circumferential direction, and a plurality of reaction cup receiving stations 406 arranged at intervals are formed in the annular groove, such as Figure 5As shown, a plurality of through holes 405 are provided along the circumferential direction on the top surface of the rotating disk 403, each through hole 405 can be installed with a reaction cup 700, and the bottom of the reaction cup 700 is inserted into the annular groove. When the rotating disk 403 drives the reaction cup 700 to rotate, the annular groove plays a guiding role, and the reaction cup 700 can be guided and moved along the extension direction of the annular groove. Compared with the technical solution in the prior art in which the reaction disk 404 does not have the position judgment and identification function, the present application sets a position optical coupling member 411 and a position matching member capable of judging the position of the reaction cup receiving station 406 on the reaction disk 404, and can accurately control the pause of the rotating disk 403 to add samples or reagents into the reaction cup 700 by identifying whether the reaction cup 700 has reached the position of the reaction cup receiving station 406, thereby ensuring the accuracy of the addition of samples or reagents.
[0126] In one embodiment, the optical coupling assembly also includes a reset optical coupling member disposed on the reaction disk 404 and a light blocking column disposed on the rotating disk 403, and the reset optical coupling member and the light blocking column cooperate to detect whether the rotating disk 403 has reached the reset initial position. In this way, when the reaction cup 700 on the reaction disk 404 has completed the sample loading, the rotating disk 403 rotates to the initial position; during the rotation of the rotating disk 403, when the light blocking column moves to the position of the reset optical coupling member, the reset optical coupling member identifies the light blocking column and sends a reset position signal, indicating that the rotating disk 403 has been reset to the initial position at this time. Preferably, the reset optical coupling member and the position optical coupling member 411 can both be optical coupling sensors commonly used in the prior art.
[0127] Specifically, in the first embodiment, Fig.18 As shown, the position matching member is a reaction hole position 410 opened on the peripheral wall of the rotating cover plate 4032, and the reaction hole position 410 is arranged corresponding to the position of the through hole 405. The reaction hole position 410 can be a U-shaped groove structure, and the number of the reaction hole position 410, the number of the through hole 405 and the number of the reaction cup receiving station 406 are the same. When the rotating disk 403 rotates to a suitable position, the reaction hole position 410, the through hole 405 and the reaction cup receiving station 406 can be made to correspond one to one. For example, when the rotating disk 403 rotates, the position optical coupler 411 always detects the reaction hole position 410. When the reaction hole position 410 does not correspond to the position of the position optical coupler 411, the position optical coupler 411 sends an electrical signal of "0"; when the reaction hole position 410 corresponds to the position of the position optical coupler 411, the position optical coupler 411 sends an electrical signal of "1", indicating that the reaction hole position 410 has moved to the position corresponding to the reaction cup receiving station 406, and reagents or samples can be added to the reaction cup 700.
[0128] like Figures 19 to 21As shown, the cup-dropping module 800 of the present invention comprises a gripping mechanism 801, a cup-dropping pushing block 802, a lifting drive mechanism 803 and a translation mechanism 804; the gripping mechanism 801 comprises an elastic clamping member 8011, a lifting plate 8012 and two clamping bodies 8013 slidably connected to the lifting plate 8012, the two clamping bodies 8013 are arranged opposite to each other along a third direction and form a clamping groove, and the two ends of the elastic clamping member 8011 are respectively connected to the two clamping bodies 8013; the cup-dropping pushing block 802 is located between the two clamping bodies 8013 and is used to abut against the two clamping bodies 8013, so that the two clamping bodies 8013 slide opposite to each other along the third direction; The driving mechanism 803 is used to drive the lifting plate 8012 to reciprocate between the grabbing position and the material throwing position relative to the cup throwing push block 802 along the fourth direction; wherein, the reaction cup 700 can extend into the clamping groove at the grabbing position and tension the elastic clamping member 8011, so that the elastic clamping member 8011 applies an elastic clamping force to the clamping body 8013, and the cup throwing push block 802 can squeeze the clamping body 8013 at the material throwing position, and make the two clamping bodies 8013 slide in opposite directions along the third direction to overcome the elastic clamping force and release the reaction cup 700; the translation mechanism 804 is used to drive the lifting driving mechanism 803 and the grabbing mechanism 801 to translate synchronously along the third direction. It can be understood that the third direction in this embodiment is Fig.19 The fourth direction is the up and down direction. The lifting drive mechanism 803 can drive the lifting plate 8012 to lift and lower along the up and down directions. The translation mechanism 804 can drive the grabbing mechanism 801, the cup-throwing push block 802 and the lifting drive mechanism 803 to translate synchronously along the left and right directions.
[0129] Before the reaction cup 700 is grabbed by the present application, the reaction cup 700 can be placed on a side close to the clamping groove so that the cup-losing push block 802 and the reaction cup 700 are arranged opposite to each other. At this time, the clamping body 8013 is located between the cup-losing push block 802 and the reaction cup 700. When the reaction cup 700 needs to be grabbed, the lifting plate 8012 can be driven by the lifting drive mechanism 803 to drive the clamping body 8013 to move to the grabbing position along the fourth direction. In the process of moving to the grabbing position, the reaction cup 700 is located between the two clamping bodies 8013 and can abut against the two clamping bodies 8013 at the same time. The size of the reaction cup 700 is larger than the size of the clamping groove, which can drive the two clamping bodies 8013 to overcome the elastic force of the elastic clamping piece 8011, so that the two clamping bodies 8013 slide synchronously back and forth along the third direction until the clamping body 8013 moves to the grabbing position, the reaction cup 700 extends into the clamping groove and the elastic clamping piece 801 is tensioned. 1. The elastic clamping member 8011 can apply an elastic clamping force to the clamping body 8013, so that the two clamping bodies 8013 clamp the clamping body 8013 under the action of the elastic clamping force. After the grabbing action is completed, the translation mechanism 804 can drive the grabbing mechanism 801, the cup-throwing pushing block 802 and the lifting and lowering driving mechanism 803 to move synchronously to the designated position along the third direction. After the reaction cup 700 moves to the designated position, the lifting and lowering driving mechanism 803 can drive the clamping body 8013 to move to the material-throwing position through the lifting plate 8012. In the process of moving to the material-throwing position, the cup-throwing pushing block 802 can simultaneously abut against the two clamping bodies 8013, so that the clamping body 8013 overcomes the elastic clamping force of the elastic clamping member 8011 under the push of the cup-throwing pushing block 802 and moves back and forth along the third direction until the gap size between the two clamping bodies 8013 is larger than the size of the reaction cup 700, and the clamping body 8013 can release the reaction cup 700. The gripping method of the present application has a simple structure, and the clamping body 8013 and the lifting plate 8012 are slidably connected. The sliding method can reduce the wear of the gripping mechanism 801, thereby extending the service life of the cup gripping mechanism.
[0130] like Fig. 20 As shown, in one embodiment, the gripping mechanism 801 further includes a first horizontal guide rail 8014 and a sliding assembly, wherein the first horizontal guide rail 8014 is disposed on the lifting plate 8012; the sliding assembly and the clamping body 8013 are detachably connected, and the sliding assembly is provided with a slide groove that is in sliding contact with the first horizontal guide rail 8014. The lifting plate 8012 and the clamping body 8013 are slidably connected via the sliding assembly, and the sliding assembly and the clamping body 8013 are detachably connected. In the case where the sliding assembly or the clamping body 8013 is damaged, the sliding assembly or the clamping body 8013 can be replaced separately, which greatly facilitates the maintenance and replacement of the cup gripping mechanism, and does not require the entire gripping mechanism 801 to be replaced, thereby reducing the use cost of the cup gripping mechanism.
[0131] In one embodiment, the sliding assembly includes a wear-resistant slider 8015 and a second connecting plate 8016, a sliding groove is provided on one side of the wear-resistant slider 8015; the second connecting plate 8016 and the other side of the wear-resistant slider 8015 are detachably connected, the clamping body 8013 is provided with a positioning groove for positioning and matching with the second connecting plate 8016, the second connecting plate 8016 is provided with a clamping groove for clamping with the wear-resistant slider 8015, and the clamping body 8013 and the second connecting plate 8016 are detachably connected. After the positioning groove of the clamping body 8013 and the second connecting plate 8016 are initially positioned, the clamping body 8013 and the second connecting plate 8016 can be further connected by a detachable connecting member, which can facilitate the assembly between the second connecting plate 8016 and the clamping body 8013, while improving the assembly accuracy and reducing the assembly error. It should be noted that the clamping body 8013 is provided with a roller 8017 for rolling contact with the cup-losing pusher 802, and the two clamping bodies 8013 form an avoidance groove for the cup-losing pusher 802 to extend into, and the roller 8017 is arranged close to the avoidance groove. In this embodiment, the roller 8017 is located at the top of the clamping body 8013, and the cup-losing pusher 802 can extend into the gap between the two rollers 8017 and roll in contact with the two rollers 8017. In this embodiment, the cup-losing pusher 802 and the clamping body 8013 push against each other by rolling contact, which can reduce the friction and loss between the cup-losing pusher 802 and the clamping body 8013, and further ensure the service life of the cup-grabbing mechanism. In order to facilitate the cup-losing pusher 802 to further push against the clamping body 8013, an avoidance groove for the cup-losing pusher 802 to extend into is arranged between the roller 8017 and the clamping groove, which improves the convenience of use of the cup-grabbing mechanism.
[0132] like Fig.21 As shown, a positioning column 8018 is provided on the lifting plate 8012 and is located between the two clamping bodies 8013 along the third direction. The positioning column 8018 is located between the avoidance groove and the clamping groove along the fourth direction. The clamping body 8013 is provided with a limiting groove that cooperates with the positioning column. The positioning column 8018 in this embodiment is located between the avoidance groove and the clamping groove. The positioning column 8018 is cylindrical and extends in the front-back direction. The limiting groove is semicircular. The two clamping bodies 8013 are arranged outside the positioning column 8018. When the cup-throwing push block 802 or the reaction cup 700 pushes the clamping body 8013, the positioning column 8018 can separate the two clamping bodies 8013 from each other, which can avoid the situation where the two clamping bodies 8013 move in the same direction, and can improve the use efficiency of the cup-grabbing mechanism.
[0133] In one embodiment, a guide portion with an opening is provided at one end of the clamping groove facing the reaction cup 700, and the cross-sectional size of the guide portion gradually decreases from the opening along the fourth direction; and a guide tip is provided at one end of the cup-dropping push block 802 facing the clamping body 8013, and the guide tip is provided with a guide inclined surface for contacting the clamping body 8013. The guide portion in this embodiment is provided with a chamfer design, and when the reaction cup 700 abuts against the clamping body 8013, the guide portion can guide the reaction cup 700, so as to facilitate the reaction cup 700 to enter the clamping groove. In this embodiment, the inner circle of the clamping body 8013 is chamfered. When the clamping body 8013 is driven downward, the clamping body 8013 will overcome the force of the elastic clamping piece 8011 and open the chamfer to clamp the reaction cup 700, and then the clamping body 8013 is clamped by the elastic clamping piece 8011. The lifting drive mechanism 803 drives the clamping body 8013 to move upward to realize the transfer of the reaction cup 700. In this embodiment, the cup-losing push block 802 is arranged in a T-shape as a whole, and a guide tip is arranged at the lower end, and the guide inclined surface of the guide tip can be in rolling contact with the roller 8017.
[0134] In one embodiment, the translation mechanism 804 includes a translation drive member 8041, a transverse support plate 8042, a transmission assembly and a tensioning adjustment assembly 8043. The transverse support plate 8042 is provided with a second horizontal guide rail 3072. The translation drive member 8041 is installed on the transverse support plate 8042. The lifting drive mechanism 803 and the second horizontal guide rail 3072 are in sliding contact and cooperation; the transmission assembly is installed on the transverse support plate 8042. The transmission assembly includes a transmission wheel and a transmission chain connected to the transmission wheel. The translation drive member 8041 is used to drive the transmission wheel to rotate; the number of transmission wheels is at least two, and the tensioning adjustment assembly 8043 is connected to one of the transmission wheels and is used to adjust the interval between the transmission wheels to tension the transmission chain.
[0135] In this embodiment, the translation drive member 8041 can be a motor, which can drive the transmission wheel to rotate. The transmission wheel drives the translation skateboard to translate along the second horizontal guide rail 3072 through the transmission chain. The second horizontal guide rail 3072 extends in the left and right directions. In the case that the transmission chain becomes loose due to long-term use, the interval between the transmission wheels can be adjusted by the tensioning adjustment component 8043, and the transmission chain sleeved outside the transmission wheel can be tensioned to avoid poor transmission due to loose transmission chain.
[0136] Among them, the number of transmission wheels is preferably two, and the tensioning adjustment component 8043 is located between the two transmission wheels. The tensioning adjustment component 8043 may include an adjusting member and an adjusting plate. The adjusting plate is connected to the central axis of the transmission wheel, and the adjusting plate is provided with an adjusting inclined surface with an adjusting groove. The pressure of the adjusting plate on the transmission wheel can be adjusted by the position of the adjusting member in the adjusting groove, thereby adjusting the transmission wheel interval.
[0137] It can be understood that the cup grabbing mechanism further includes a first sensor installed at an initial position on the transverse support plate 8042 and a second sensor installed at a final position on the transverse support plate 8042. The grabbing mechanism 801 is located between the initial position and the final position along the third direction. The first sensor and the second sensor are used to detect the grabbing mechanism 801, the cup-throwing pusher block 802, and the lifting drive mechanism 803, and shut down the translation drive member 8041 when the grabbing mechanism 801, the cup-throwing pusher block 802, or the lifting drive mechanism 803 is detected. In one embodiment, the first sensor and the second sensor can both be photoelectric sensors. The transverse support plate 8042 extends in the left-right direction. Two baffles can be respectively provided on the translation slide plate corresponding to the first sensor and the second sensor on the transverse support plate 8042. The two baffles serve as detection structures. When the first sensor and the second sensor detect the baffles, the translation drive member 8041 is shut down. In other embodiments, the detection structures corresponding to the first sensor and the second sensor can be set at other positions on the gripping mechanism 801, the cup-throwing pusher block 802, and the lifting drive mechanism 803. The first sensor and the second sensor shut down the translation drive member 8041 when the detection structures are detected. The first sensor is set close to the right end of the horizontal guide rail 3072, and the second sensor is set close to the left end of the horizontal guide rail 3072. In this embodiment, the first sensor and the second sensor can sense the gripping mechanism 801, the cup-throwing pusher block 802, and the lifting drive mechanism 803 to determine whether the clamping body 8013 is in place, and the translation drive member 8041 can be fully shut down automatically, thereby improving the convenience of operation of the cup-grabbing mechanism.
[0138] In one embodiment, if Fig.19 As shown, the cup grabbing mechanism also includes a bracket 805 supporting the horizontal support plate 8042. A third sensor is arranged on the bracket 805 corresponding to the final position. The third sensor is used to detect the reaction cup 700, and start the lifting drive mechanism 803 when the reaction cup 700 is detected, so that the lifting drive mechanism 803 drives the clamping body 8013 to move to the material throwing position.
[0139] In one embodiment, the lifting drive mechanism 803 includes a translation slide, a lifting drive member and a fourth sensor; the translation slide is provided with a lifting guide rail 3072, the lifting plate 8012 and the lifting guide rail 3072 are in sliding contact and cooperation, and the translation mechanism 804 is used to drive the translation slide to translate; the lifting drive member is installed on the translation slide and is used to drive the lifting plate 8012 to lift; the fourth sensor is installed on the translation slide, and the fourth sensor is used to shut down the lifting drive member when it is detected that the clamping body 8013 is located at the material loss position. The lifting drive member in this embodiment can be a motor, and the output end of the motor can be connected to a screw rod, and the lifting plate 8012 can be provided with a threaded hole that is threadedly connected to the screw rod. When the motor drives the screw rod to rotate forward or reverse, the screw rod extends in the up and down direction, and the lifting plate 8012 can be lifted and lowered along the screw rod. At the same time, the lifting plate 8012 and the lifting guide rail 3072 guide cooperation can ensure the accuracy of the lifting trajectory of the lifting plate 8012. The fourth sensor in this embodiment may be a photoelectric sensor, and a photoelectric baffle 305 extending into the photoelectric slot of the photoelectric sensor may be installed on the lifting plate 8012 .
[0140] For ease of understanding, the working principle of the entire sample analysis device is further described as follows: First, the reagents required in the reaction process are stored in the reagent compartment module, and the reagents are mixed and refrigerated through the reagent compartment module; the injection module is used to store sample tubes and has a code scanning and recognition function and a cover function, and the cup arrangement module places the reaction cup in the incubation module to wait for the incubation reaction; when the test starts, the reagent transfer module is used to transfer the sample in the injection module to the reaction cup in the incubation module, and transfer the reagent in the reagent compartment module to the reaction cup in the incubation module, and react with the sample in the reaction cup, and after the cleaning of the cleaning and injection assembly is completed, the reagent in the reaction cup is transferred to the detection module for detection and analysis. After the detection and analysis is completed, the cup throwing module will absorb the remaining liquid in the reaction cup that has been cleaned into the waste liquid barrel and then clamp it and throw it to the waste recovery module. The entire sample analysis device of the present application has a high degree of automation, which improves the detection efficiency, and integrates multiple modules on the rack to improve space utilization.
Claims
1. A sample analysis device, It is characterized in that The invention comprises a frame and: A reagent storage module (100) is used to store reagents required during the reaction process; A sample injection module (200), used for storing a sample tube (17); The cup arrangement module (300) is used to arrange the empty reaction cups (700) and vertically lower the empty reaction cups (700) to the unloading end in sequence; An incubation module (400) connected to a discharge end of the cup sorting module (300), the incubation module (400) being used to receive and accommodate the empty reaction cups (700) transported by the cup sorting module (300); A transfer module (500) moves between the reagent chamber module (100), the injection module (200) and the incubation module (400), the transfer module (500) being used to transfer the sample in the injection module (200) and the reagent in the reagent chamber module (100) to the reaction cup (700) in the incubation module (400), and the incubation module (400) being used to perform a mixing and incubation reaction on the reagent and the sample in the reaction cup (700); and The detection module (600) is used to detect the reagents that have completed the incubation reaction in the incubation module (400).
2. The sample analysis device according to claim 1, It is characterized in that The reagent storage module (100) comprises: Warehouse body (1); A mixing mechanism (2), arranged inside the chamber (1) and used for mixing the sample; A first refrigeration unit (3) and a second refrigeration unit (4), used for refrigerating the warehouse body (1) and arranged below the warehouse body (1) at intervals in the transverse direction, wherein the first refrigeration unit (3) and the second refrigeration unit (4) are both distributed in the longitudinal direction; A third driving mechanism is arranged between the first refrigeration unit (3) and the second refrigeration unit (4) and comprises a driving motor, a driving shaft (503) and a synchronous pulley assembly (502) distributed in the longitudinal direction, wherein the top end of the driving shaft (503) penetrates upward through the bottom wall of the bin body (1) and is connected to the mixing mechanism (2), and the bottom end of the driving shaft (503) is connected to the synchronous pulley assembly (502), and the driving motor is arranged in the vertical direction and is used to drive the synchronous pulley assembly (502).
3. The sample analysis device according to claim 2, It is characterized in that The reagent storage module (100) further comprises: A sample tube (17) is detachably inserted into the mixing mechanism (2); A reset component, used to reset the mixing mechanism (2) and comprising: A reset optical coupling sheet (1601) is arranged on the top or bottom of the driven wheel of the synchronous pulley assembly (502) and is formed with a first detection portion; A reset optical coupler (1602), arranged on a side of the driven wheel away from the driving motor and used to detect the first detection unit; A position detection assembly, used for detecting the rotational position of the sample tube (17), comprising: A position detection optical coupling piece (1801) is arranged on the driven wheel and is vertically spaced apart from the reset optical coupling piece (1601), wherein the position detection optical coupling piece (1801) is formed with a plurality of second detection parts spaced apart along the circumferential direction; The position detection optical coupler (1802) is vertically spaced apart from the reset optical coupler (1602) and is used to detect the second detection unit.
4. The sample analysis device according to claim 3, It is characterized in that The reagent storage module (100) further comprises: A first cold-isolating plate (13) is arranged at the bottom of the warehouse body (1); A motor mounting seat (14) is arranged below the first cold-isolating plate (13), and a first mounting cavity (15) is formed between the motor mounting seat (14) and the first cold-isolating plate (13); The driving wheel of the synchronous pulley assembly (502) is installed in the first installation cavity (15) along the horizontal direction, and the driving end of the driving motor passes through the bottom wall of the motor mounting seat (14) upwards and is drivingly connected to the driving wheel; An optical coupler mounting seat (19) for mounting the reset optical coupler (1602) and the position detection optical coupler (1802); A second cold-isolating plate (20) is arranged below the warehouse body (1) and is used to install the optical coupling mounting seat (19).
5. The sample analysis device according to claim 1, It is characterized in that The sample injection module (200) comprises: A mounting platform (21) is provided with a sample conveying area (22) and a cover opening area (23) located on a lateral side of the sample conveying area (22); A sample tray (202) is disposed in the sample conveying area (22) in a longitudinally movable manner and is formed with a first conveying channel for loading a sample rack (203); A sampling track (204) is arranged in the transverse direction in the cover opening area (23) and is capable of communicating with the first conveying channel; A first driving mechanism, disposed below the sampling track (204), and used to drive the sample rack (203) on the sample tray (202) to move back and forth between the first conveying channel and the sampling track (204); A pressing mechanism (206), arranged in the cover opening area (23) and located on one longitudinal side of the sampling track (204), and used for pressing the tube body of the sample tube (17); The cover opening mechanism (208) is arranged in the cover opening area (23) and is located on a side of the pressing mechanism (206) away from the sampling track (204), and is used to open the tube cover of the sample tube (17).
6. The sample analysis device according to claim 5, It is characterized in that The number of the first delivery channels is multiple, and the injection module (200) further includes: A sensing device, used for sensing the sample rack (203) entering the first transport channel; The second driving mechanism (213) is used to drive the sample tray (202) to move to a position where the first conveying channel is flush with the sampling track (204).
7. The sample analysis device according to claim 5, It is characterized in that The sample injection module (200) further comprises a lifting mechanism (220) and a connecting arm (221), wherein the lifting mechanism (220) is movably arranged on the mounting platform (21) and is located on a side of the pressing mechanism (206) away from the sample rack (203), and the connecting arm (221) is arranged on the top of the lifting mechanism (220); The cover opening mechanism (208) comprises a cover opening drive member (2081), a pivot shaft (2082), and two clamping members (2083), wherein the pivot shaft (2082) is vertically arranged on the connecting arm (221), and the clamping member (2083) comprises a connecting portion and a clamping portion, wherein the upper end of the clamping portion is connected to the connecting portion and can clamp the tube cover of the sample tube (17) from both ends, and the connecting portion is rotatably arranged on the pivot shaft (2082) in the horizontal direction, and a clamping space for clamping the tube cover is formed between the two clamping portions, and the cover opening drive member (2081) is horizontally arranged above the connecting arm (221) and is used to drive the two clamping portions to move closer to or away from each other.
8. The sample analysis device according to claim 1, It is characterized in that The incubation module (400) comprises: An incubation plate, comprising a rotating plate (403) and a reaction plate (404), wherein the rotating plate (403) is provided with a plurality of through holes (405) for receiving reaction cups (700) along a circumferential direction, and a reaction cup receiving station (406) for inserting the bottom of the reaction cup (700) is formed on the reaction plate (404); A stirring assembly (401), installed below the reaction disk (404) and used to stir and mix the reagents and samples in the reaction cup (700); A second rotation driving assembly (402), used for driving the rotating disk (403) to rotate; an optical coupling component, which is disposed on the reaction disk (404) and obtains corresponding position information of the through hole (405) and the reaction cup receiving station (406) and sends a judgment signal; and A control unit is electrically connected to the optical coupling component and controls the second rotation drive component (402) to operate according to the received judgment signal, so that the through holes (405) and the reaction cup receiving stations (406) correspond one to one.
9. The sample analysis device according to claim 8, It is characterized in that The rotating disk (403) comprises a rotating ring (4031) coaxially arranged at intervals on the inner circumference of the reaction disk (404) and a rotating cover plate (4032) covering the rotating ring (4031), and a cover body is provided on the rotating cover plate (4032). The incubation module (400) further comprises: Mounting table (407); The cleaning and liquid injection components (408) are at least two in number and are arranged on the mounting platform (407) at intervals along an arc. In the rotation direction of the rotating cover plate (4032), the cleaning and liquid injection components (408) located at the last position are used to absorb the remaining liquid in the reaction cup (700), and the remaining cleaning and liquid injection components (408) are used to absorb the liquid in the reaction cup (700) and inject cleaning liquid; A lifting drive assembly (409) is installed on the cover body and is used to drive the mounting platform (407) to rise and fall.
10. The sample analysis device according to claim 9, It is characterized in that The cleaning and injection assembly (408) comprises: A guide sleeve movably passing through the mounting platform (407); and a reaction needle integrated in the guide sleeve, the reaction needle being used to absorb the liquid in the reaction cup (700) or inject cleaning liquid into the reaction cup (700), the reaction needle located at the rear position comprising an absorption needle (4081) for absorbing the liquid in the reaction cup (700), and the remaining reaction needles comprising an injection needle (4082) for injecting cleaning liquid into the reaction cup (700) and an absorption needle (4081) for absorbing the liquid in the reaction cup (700), the bottom of the absorption needle (4081) being located at a plane higher than the bottom of the injection needle (4082) being located.
11. The sample analysis device according to claim 8, It is characterized in that The optical coupler assembly comprises: Position matching parts, the number of which is plural, and the plurality of position matching parts are arranged on the rotating disk (403) along the circumferential direction and correspond one by one to the reaction cup receiving stations (406); A position optical coupler (411), wherein the position optical coupler (411) cooperates with the position matching component to obtain the position information of the reaction cup receiving station (406), and sends a judgment signal according to the position information; and A reset optical coupler (412) is arranged on the reaction disk (404), and a light-blocking column is arranged on the rotating disk (403). The reset optical coupler (412) and the light-blocking column cooperate to detect whether the rotating disk (403) reaches the reset initial position.
12. The sample analysis device according to claim 1, It is characterized in that The cup sorting module (300) comprises: A reaction cup loading bin (301), used for holding the reaction cup (700); The cup unscrambling drum (302) has a plurality of partitions (304) spaced apart on its inner circumferential wall, the partitions (304) are arranged obliquely relative to the inner circumferential wall of the cup unscrambling drum (302), and a guide channel (303) is formed between any two adjacent partitions (304), and a feed end of the guide channel (303) is connected to a discharge end of the reaction cup charging bin (301); a baffle (305) located on a side of the cup-arranging drum (302) away from the reaction cup loading bin (301), and a cup outlet (308) for discharging the reaction cup (700) is formed on the baffle (305); a first rotating drive assembly (306) for driving the cup unscrambling drum (302) to rotate, so as to drive the discharge end of each guide channel (303) to rotate in sequence to a position communicating with the cup outlet (308); and A cup pushing mechanism comprises a conveying assembly and a cup pushing assembly (307), wherein the conveying assembly forms a cup drop opening (315) and a second conveying channel (309) connected to the cup outlet (308), and the cup pushing assembly (307) is used to push the reaction cups (700) in the second conveying channel (309) to the cup drop opening (315) in sequence; the cup pushing assembly (307) comprises: Pushing member (3071); A guide rail (3072) installed on the outer side wall of the conveying guide block (310) along the first direction; a second linear driving member (3074), used for driving the pushing member (3071) to approach or move away from the reaction cup (700) in the cup dropping channel (313) along a second direction, wherein the first direction intersects with the second direction; and The first linear driving member (3073) is mounted on the guide rail (3072) and is used to drive the second linear driving member (3074) to move linearly along a first direction.
13. The sample analysis device according to claim 1, It is characterized in that The sample analysis device further comprises a cup discarding module (800), wherein the cup discarding module (800) is used to grab the reaction cup (700) after the reaction is completed in the incubation module (400), and discard the discarded reaction cup (700) to the waste recovery module; The cup-dropping module (800) comprises: The gripping mechanism (801) comprises an elastic clamping member (8011), a lifting plate (8012) and two clamping bodies (8013) slidably connected to the lifting plate (8012), the two clamping bodies (8013) being arranged opposite to each other and surrounding a clamping groove, the two ends of the elastic clamping member (8011) being respectively connected to the two clamping bodies (8013), the clamping bodies (8013) being provided with rollers (8017) for rolling contact with the cup-throwing pushing block (802), the two clamping bodies (8013) surrounding a avoiding groove for the cup-throwing pushing block (802) to extend into, and the rollers (8017) being arranged close to the avoiding groove; The cup-throwing pusher (802) is located between the two clamping bodies (8013) and is used to abut against the two clamping bodies (8013) to make the two clamping bodies (8013) slide back to back; A lifting drive mechanism (803) is used to drive the lifting plate (8012) to reciprocate between a grabbing position and a cup throwing position relative to the cup throwing push block (802); The reaction cup (700) can extend into the clamping groove at the grasping position and tighten the elastic clamping member (8011), so that the elastic clamping member (8011) applies an elastic clamping force to the clamping body (8013), and the cup-dropping push block (802) can squeeze the clamping body (8013) at the cup-dropping position, and make the two clamping bodies (8013) slide in opposite directions to overcome the elastic clamping force and release the reaction cup (700); The translation mechanism (804) is used to drive the lifting drive mechanism (803) and the grasping mechanism (801) to translate synchronously.
Citation Information
Cited By
Immune cell detector and detection method thereof
CN120405167A