Isotope sample pretreatment automation system

Abstract

The invention discloses an automatic pretreatment system for an isotope sample, and belongs to the technical field of isotope separation, purification, analysis and testing in geology. The automatic isotope sample pretreatment system comprises a leacheate module, a sample liquid module, an automatic liquid adding module, a liquid transferring module, a liquid adding and transferring module, a resin column module and a sample receiving module, the automatic liquid adding module is communicated with the leacheate module and the liquid transferring module, and the liquid adding and transferring module is in transmission fit with the liquid transferring module; the leacheate module is at least used for containing leacheate, the sample liquid module is at least used for containing a sample solution to be treated, the resin column module comprises a resin column, and the automatic liquid adding module is at least used for extracting the leacheate in the leacheate module and conveying extracted cleaning liquid to the liquid transferring module; the pipetting module is at least used for injecting the leacheate into the resin column, extracting the sample solution in the sample solution module and injecting the sample solution into the resin column, and the sample receiving module is used for receiving the liquid flowing out of the resin column module.

Description

Technical Field

[0001] The invention particularly relates to an isotope sample pre-processing automation system, and belongs to the technical field of isotope separation, purification, analysis and testing in geology. Background Art

[0002] Isotope analysis has a wide range of applications in the field of science and technology, especially in the fields of geology, oceanography, environmental science, etc. It is considered one of the commanding heights of science and technology. Isotope analysis reveals the laws of element migration, transformation and fate in nature by studying the changes in isotope ratios, which is of great significance for a deep understanding of the material cycle and change laws in nature. With the rapid development of the isotope field, the demand for analysis of large data sets of isotope composition has increased significantly. At present, both multi-collector inductively coupled plasma mass spectrometers (MC-ICP-MS) and thermal ionization mass spectrometers (Triton) use automated analysis and testing, which can achieve efficient and rapid isotope analysis. However, separation and purification of target isotopes from the matrix is ​​a prerequisite for achieving high-precision isotope analysis. In the pre-treatment of isotope samples (especially non-traditional stable isotopes), due to the lack of efficient automated equipment, the only method for isotope separation and purification is the traditional manual drip resin method, which takes up more than 90% of the time in the entire isotope analysis, and this part of the work is almost entirely done manually, which is complicated, time-consuming and labor-intensive, and the human factor makes it difficult to ensure the stability and accuracy of the data, which is the biggest technical bottleneck faced by the existing isotope separation and purification methods. Therefore, it is urgent to develop an automated and intelligent isotope sample pre-treatment system to greatly reduce the workload of personnel, improve work efficiency, and further promote the new development and new application of isotope analysis.

[0003] In recent years, an automated platform based on commercial ion chromatography systems has been gradually established. Ireland et al. developed a Teflon-HPLC column chromatography system using N 2Pressure drives the eluent for elemental chemical separation and enrichment. This system is prone to bubbles in gas pressure mode, making it difficult to accurately control the flow rate and there is a risk of cross-contamination. Elemental Scientific has launched the prepFAST MC column chromatography system, which uses a syringe pump to drive the eluent to pass different sample solutions into the chromatographic column through the same flow path, with potential risks of cross-contamination and memory effect. In addition, there are scholars who use siphon effect (gravity) drive and infrared droplet counting for quantitative control of open column chromatography systems, as well as open column chromatography systems controlled by multi-channel syringe pumps and ten-way valves. Usually, due to the inconsistent leaching rate of each column in the open column chromatography system, it is possible that bubbles will be generated after the eluent in some columns flows out, leading to embolism. However, although certain research results have been achieved in automated column flow, there are still many problems, and it has not been widely used in the field of non-traditional stable isotope geochemistry.

[0004] After comprehensive analysis, in order to improve work efficiency, ensure data stability and accuracy, and reduce the workload of staff, an automated high-throughput equipment has been developed that integrates resin purification, sample loading, elution and target isotope collection in the isotope sample pretreatment process. This equipment can meet the pretreatment needs of non-traditional stable isotopes such as Li, Sr, Mg, K, Ca and other elements, further promote the development of isotope analysis, and more effectively promote scientific and technological innovation in the direction of instrument development. Summary of the invention

[0005] The main purpose of the present invention is to provide an automated system for isotope sample pretreatment, thereby overcoming the deficiencies in the prior art.

[0006] In order to achieve the above-mentioned invention object, the technical solution adopted by the present invention includes:

[0007] The embodiment of the present invention provides an isotope sample pre-treatment automation system, which includes: an eluent module, a sample liquid module, an automatic liquid adding module, a liquid transfer module, a liquid adding and transferring module and a resin column module;

[0008] The automatic liquid adding module is respectively connected with the eluent module and the liquid transfer module, the liquid adding and transferring module is in transmission cooperation with the liquid transfer module, and the liquid adding and transferring module is at least used to drive the liquid transfer module to move along a selected track in an xy plane of a three-dimensional coordinate system, and the sample liquid module and the resin column module are located on the selected track;

[0009] The eluent module is at least used to hold the eluent, the sample liquid module is at least used to hold the sample solution to be processed, the resin column module includes a resin column, and the automatic liquid adding module is at least used to extract the eluent in the eluent module and transport the extracted cleaning liquid to the pipetting module; the pipetting module is at least used to inject the eluent into the resin column, extract the sample solution in the sample liquid module, and inject the sample solution into the resin column.

[0010] In a more specific embodiment, the eluent module includes an eluent container;

[0011] The automatic liquid adding module comprises a three-way liquid switching solenoid valve, an inlet and outlet pipe joint, a syringe pump and a first motion actuator, the three-way liquid switching solenoid valve cooperates with the inlet and outlet pipe joint, the inlet and outlet pipe joint is controllably connected with the eluent container and the syringe pump via the three-way liquid switching solenoid valve, the first motion actuator is drivingly connected with the piston of the syringe pump and is used to push and pull the piston;

[0012] The liquid transfer module comprises a three-way solenoid valve for controlling liquid discharge, a washing liquid injection tube, a liquid transfer gun and a second motion actuator, wherein the three-way solenoid valve for controlling liquid discharge is connected to the washing liquid injection tube, and the three-way solenoid valve for controlling liquid discharge is also controllably connected to the inlet and outlet pipe joint via the three-way liquid switching solenoid valve, and the second motion actuator is in transmission cooperation with the liquid transfer gun and is used to drive the liquid transfer gun to rise and fall along the z-axis of the three-dimensional coordinate system, so that the liquid transfer gun extracts the sample solution in the sample liquid module, and injects the sample solution into the resin column;

[0013] Among them, by switching the three-way liquid switching solenoid valve, the eluent container, the inlet and outlet pipe joints, the three-way liquid switching solenoid valve, and the injection pump form an inlet passage for the eluent to be transported from the eluent container to the injection pump, and the injection pump, the inlet and outlet pipe joints, the three-way liquid switching solenoid valve, the liquid outlet control three-way solenoid valve, and the eluent injection tube form an outlet passage for the eluent to be injected from the injection pump into the resin column.

[0014] In a more specific embodiment, the eluent module comprises a plurality of eluent containers, and the plurality of eluent containers are respectively used to contain a plurality of different eluents;

[0015] The automatic liquid adding module comprises a plurality of inlet and outlet pipe joints and a plurality of injection pumps, each of the inlet and outlet pipe joints is respectively connected to a eluent container and a injection pump;

[0016] The liquid transfer module comprises a plurality of three-way solenoid valves for controlling liquid discharge and a plurality of eluent injection tubes, wherein the plurality of three-way solenoid valves for controlling liquid discharge are respectively connected to the plurality of eluent injection tubes;

[0017] A plurality of liquid inlet passages are formed between the automatic liquid adding module and the eluent module, and a plurality of liquid outlet passages are formed between the automatic liquid adding module and the liquid transfer module.

[0018] Furthermore, the eluent container is provided with an eluent output pipeline joint, and the eluent output pipeline joint is connected to the inlet and outlet pipeline joint via a pipeline.

[0019] Furthermore, the eluent module also includes a storage cabinet, and the eluent container is arranged in the storage cabinet.

[0020] Furthermore, the first motion actuator includes a first driving mechanism, a first screw, and an injection pump push-pull rod. The first driving mechanism is transmission-connected to the screw body of the first screw, and the injection pump push-pull rod is fixedly connected to the screw nut of the first screw and the piston of the injection pump.

[0021] Furthermore, the first driving mechanism is a rotation driving mechanism. Exemplarily, the rotation driving mechanism may be a rotation driving motor or other mechanism capable of realizing rotational motion output.

[0022] Furthermore, the automatic liquid adding module also includes a position sensor, and the position sensor is used to detect the position of the screw nut of the first screw.

[0023] Furthermore, the automatic liquid adding module also includes a first base, and the three-way liquid switching solenoid valve, the injection pump, and the first motion actuator are assembled on the first base.

[0024] Furthermore, the position sensor is mounted on the first base, and the position of the position sensor on the first base is adjustable.

[0025] Furthermore, the second motion actuator includes a second driving mechanism and a second screw rod, the second driving mechanism is transmission-connected to a screw rod body of the second screw rod, the pipette gun is fixedly connected to a screw rod nut of the second screw rod, and the screw rod body of the second screw rod extends along the z-axis.

[0026] Furthermore, the second driving mechanism is a rotation driving mechanism. Exemplarily, the rotation driving mechanism may be a rotation driving motor or other mechanism capable of realizing rotational motion output.

[0027] Furthermore, the pipette is matched with a plurality of pipette tips, and the pipette tips and the pipette can be matched detachably.

[0028] Furthermore, the pipetting module also includes a resin column liquid adding port pipeline fixing piece, and the resin column liquid adding port pipeline fixing piece is used to limit the eluent injection tube.

[0029] Furthermore, the liquid transfer module also includes a liquid level distance sensor, and the liquid level distance sensor is used to detect the liquid level height of the eluent in the resin column.

[0030] Furthermore, the liquid level distance measuring sensor includes an ultrasonic liquid level distance measuring sensor. It should be noted that the ultrasonic liquid level distance measuring sensor is commercially available, and its specific structure and model are not limited here.

[0031] Furthermore, the pipetting module also includes a second base, the liquid outlet control three-way solenoid valve, the pipetting gun, and the second motion actuator are assembled on the second base, and the pipetting gun is movably matched with the second base.

[0032] Furthermore, the resin column liquid filling port pipeline fixing piece is fixedly assembled on the second base.

[0033] Furthermore, the liquid level distance measuring sensor is fixedly mounted on the second base.

[0034] Furthermore, the sample solution module includes a sample solution container.

[0035] Furthermore, the sample liquid module includes multiple groups of sample solution containers, which are used to accommodate different sample solutions, and the sample liquid module also includes multiple groups of pipette tips, each group of pipette tips is used to cooperate with the pipette to extract sample solutions in a group of sample solution containers.

[0036] Furthermore, the sample solution module comprises a tray, and the sample solution container and the pipette tip are placed on the tray.

[0037] Furthermore, the sample solution container and the pipette tip are placed on the tray in sequence along the x-axis direction of the three-dimensional coordinate system, and the sample liquid module also includes a third motion actuator, which is in transmission cooperation with the tray and is used to drive the tray to reciprocate along the x-axis, and the motion trajectory of the pipetting module is parallel to the y-axis of the three-dimensional coordinate system.

[0038] Furthermore, the third motion actuator includes a third drive mechanism and a third screw rod, the third drive mechanism is transmission-connected to the screw rod body of the third screw rod, the tray is fixedly connected to the screw rod nut of the third screw rod, and the screw rod body of the third screw rod extends along the x-axis.

[0039] Furthermore, the liquid adding and transferring module includes a first guide rail, a guide seat and a fourth motion actuator. The guide seat is arranged on the first guide rail and cooperates with the first guide rail. The fourth motion actuator cooperates with the guide seat in transmission and is used to drive the guide seat to move on the first guide rail. The transfer module is fixedly assembled on the guide seat and moves synchronously with the guide seat.

[0040] Furthermore, the guide seat cooperates with the first guide rail by sliding or rolling.

[0041] Furthermore, the fourth motion actuator includes a fourth drive mechanism, a synchronous belt and a synchronous wheel. The synchronous wheel is assembled on the first guide rail and can rotate. The synchronous belt is in transmission cooperation with the synchronous wheel. The fourth drive mechanism is in transmission cooperation with the synchronous wheel. The guide seat is fixedly cooperated with the synchronous belt.

[0042] Furthermore, the fourth driving mechanism and the third driving mechanism are rotational driving mechanisms. Exemplarily, the rotational driving mechanisms may be rotational driving motors or other mechanisms capable of realizing rotational motion output.

[0043] Furthermore, the first guide rail extends along the y-axis of the three-dimensional coordinate system.

[0044] In a more specific embodiment, the resin column module further includes a fixing seat, and the resin column is fixed on the fixing seat.

[0045] In a more specific embodiment, the automated isotope sample preprocessing system further includes: a sample receiving module, which is disposed below the resin column module along the z-axis and is at least used to receive liquid flowing out of the resin column module.

[0046] Furthermore, the sample receiving module includes a sample receiving container.

[0047] Furthermore, the sample receiving module also includes a fifth motion execution mechanism, which is in transmission cooperation with the sample receiving container and is used to drive the sample receiving container to move along the xy plane of the three-dimensional coordinate system.

[0048] Furthermore, the sample receiving module also includes a waste liquid tray, the sample receiving container is arranged on the waste liquid tray, and the fifth motion actuator cooperates with the waste liquid tray and is used to drive the waste liquid tray to move along the x-axis of the three-dimensional coordinate system.

[0049] Furthermore, the fifth motion actuator includes a fifth driving mechanism and a fifth screw rod, the fifth driving mechanism is transmission-connected to the screw rod body of the fifth screw rod, and the waste liquid tray is fixedly connected to the screw rod nut of the fifth screw rod.

[0050] Furthermore, the sample receiving module also includes a second guide rail, the waste liquid tray is movably cooperated with the second guide rail, and can reciprocate along the second guide rail under the drive of the fifth motion actuator, and the second guide rail extends along the x-axis of the three-dimensional coordinate system.

[0051] Furthermore, the sample receiving module also includes a lifting platform, a platform lifting bracket, and a sixth motion actuator. The lifting platform is fixedly arranged on the platform lifting bracket, the fifth motion actuator and the second guide rail are arranged on the lifting platform, and the sixth motion actuator is in transmission cooperation with the platform lifting bracket and is used to drive the platform lifting bracket to extend and retract along the z-axis of the three-dimensional coordinate system, so that the fifth motion actuator, the second guide rail and the lifting platform are synchronously lifted and lowered along the z-axis.

[0052] Furthermore, the sixth motion actuator includes a sixth driving mechanism and a sixth screw rod, the sixth driving mechanism is transmission-connected to the sixth screw rod, the sixth screw rod is transmission-connected to the platform lifting bracket, and the platform lifting bracket is an X-shaped telescopic bracket.

[0053] Furthermore, the sample receiving module also includes a translation platform and a third guide rail, the translation platform is arranged on the third guide rail and movably cooperates with the third guide rail, the platform lifting bracket and the sixth motion actuator are arranged on the translation platform, the translation platform is arranged on the third guide rail, and the third guide rail extends along the x-axis of the three-dimensional coordinate system.

[0054] In a more specific embodiment, the isotope sample preprocessing automation system also includes: a control module, which is signal-connected to the automatic liquid adding module, the pipetting module, and the liquid adding and transferring module, and is at least used to adjust the working status of the automatic liquid adding module, the pipetting module, and the liquid adding and transferring module.

[0055] Furthermore, the control module is also signal-connected to the sample receiving module, and the control module is also used to adjust the working state of the sample receiving module.

[0056] Furthermore, the control module includes a control screen.

[0057] Compared with the prior art, the advantages of the present invention include:

[0058] An isotope sample pretreatment automation system provided in an embodiment of the present invention can realize the separation, purification and enrichment of target isotopes in a fully automated process, truly realizing unattended operation;

[0059] An automated isotope sample pretreatment system provided in an embodiment of the present invention can meet the needs of most common non-traditional stable isotope separation and purification (such as Li, Sr, Mg, Ca, etc.), and can process at least 20 samples at a time;

[0060] In an automated isotope sample pretreatment system provided in an embodiment of the present invention, an ultrasonic ranging sensor can accurately detect the liquid level in a resin column in real time, ensuring accurate operation of the entire process.

[0061] An isotope sample pretreatment automation system provided in an embodiment of the present invention can realize full-process automated processing. After the personnel place the sample, eluent, resin column, etc. on the machine, they select the corresponding pretreatment program to achieve separation, purification and enrichment of the isotope sample, truly realizing unmanned operation. At the same time, the system can accurately control the amount of each eluent added, monitor the liquid level in real time, and ensure the accuracy and consistency of the process. BRIEF DESCRIPTION OF THE DRAWINGS

[0062] Figure 1 It is a schematic diagram of the overall structure of an isotope sample pre-processing automation system provided in a typical implementation case of the present invention;

[0063] Figure 2 It is a structural schematic diagram of an eluent module provided in a typical implementation case of the present invention;

[0064] Figure 3 It is a structural schematic diagram of a sample liquid module provided in a typical implementation case of the present invention;

[0065] Figure 4 It is a structural schematic diagram of an automatic liquid adding module provided in a typical implementation case of the present invention;

[0066] Figure 5 It is a structural schematic diagram of a pipetting module provided in a typical implementation case of the present invention;

[0067] Figure 6 It is a structural schematic diagram of a liquid adding and transferring module provided in a typical implementation case of the present invention;

[0068] Figure 7 It is a structural schematic diagram of a resin column module provided in a typical implementation case of the present invention;

[0069] Figure 8 It is a structural schematic diagram of a sample receiving module provided in a typical implementation case of the present invention;

[0070] Fig. 9 It is a schematic diagram of the overall pipeline structure formed by the eluent module, the automatic liquid adding module, the pipetting module and the resin column module in a typical implementation case of the present invention. DETAILED DESCRIPTION

[0071] In view of the deficiencies in the prior art, the inventor of this case, after long-term research and extensive practice, was able to propose the technical solution of the present invention.

[0072] Currently known isotope sample pretreatment is to complete the overall isotope pretreatment process by manually adding sample solution and eluent. However, during the sample processing, it is necessary to add the solution of the next process in time according to the state of the solution filtered out in the resin column, and the solution filtration speed and time in different resin columns will be different. If the next process solution cannot be added in time after all the solution in the resin column is filtered out, the filler in the resin column will dry and crack, affecting the data results of the entire experimental process. It takes about 10 hours to complete the overall isotope pretreatment process by manually adding sample solution and eluent. It requires continuous participation of personnel at different stages, which is very labor-intensive. After each stage is completed, the next stage of flushing solution needs to be added manually. It is easy for personnel to miss the appropriate time for adding liquid, resulting in problems in the processing.

[0073] In view of the shortcomings and deficiencies of current manual processing, an isotope sample pretreatment automation system provided in an embodiment of the present invention introduces an ultrasonic liquid level ranging sensor. After liquid is added to the resin column once, the ultrasonic liquid level ranging sensor moves to the top of the resin column to monitor the liquid level in the resin column in real time. When the ultrasonic liquid level ranging sensor detects that the liquid level drops below the set value, the liquid adding action of the next process is triggered. The ultrasonic liquid level ranging sensor is driven to cyclically and uninterruptedly perform real-time inspection and monitoring of the liquid level status of 20 or more groups of resin columns, and timely control the status of the solution in each resin column. By introducing the ultrasonic liquid level ranging sensor, the automation and unmanned operation of the entire system can be realized, the time interval for liquid addition in each stage can be controlled, and the accuracy and consistency of the process flow can be guaranteed.

[0074] An automated isotope sample pretreatment system provided in an embodiment of the present invention uses a precision pipette and a precision syringe pump for sample loading and elution, thereby achieving accurate and efficient liquid addition. At the same time, an ultrasonic ranging sensor is used to monitor the liquid level in the resin column in real time to ensure that the entire elution process is accurate.

[0075] An isotope sample pretreatment automation system provided in an embodiment of the present invention adopts automated intelligent operation, has a visual touch screen, and has flexible and convenient process settings. It is fast, efficient, accurate and reliable, and can automatically complete tasks such as resin column cleaning, sample loading, leaching and target isotope collection. It is suitable for the separation, purification and enrichment of various non-traditional stable isotopes, and truly realizes unattended operation, thereby greatly reducing the workload of personnel and improving work efficiency, bringing a new era of intelligent analysis to the pretreatment of isotope samples.

[0076] The technical solution, its implementation process and principles, etc. will be further explained below in conjunction with the accompanying drawings and specific implementation cases. Unless otherwise specified, the drive motor, lead screw, sensor, solenoid valve, controller and control software used in the embodiments of the present invention are all known in the art and can be purchased commercially. The specific product structure and product model are not limited here.

[0077] Example 1

[0078] The invention discloses an automated isotope sample pretreatment system, which mainly uses chemical reagents of different concentrations and compositions to leach the anions and cations in the sample solution adsorbed by the resin in the resin column, thereby achieving the purpose of separation, purification and enrichment of the target isotope.

[0079] See also Figure 1 An isotope sample pretreatment automation system comprises an eluent module 1, a sample liquid module 2, an automatic liquid adding module 3, a liquid transfer module 4, a liquid adding and transferring module 5, a resin column module 6 and a sample receiving module 7. The eluent module 1, the sample liquid module 2, the automatic liquid adding module 3, the liquid transfer module 4, the liquid adding and transferring module 5, the resin column module 6 and the sample receiving module 7 are installed on an equipment rack. The automatic liquid adding module 3 is respectively connected to the eluent module 1 and the liquid transfer module 4. The liquid adding and transferring module 5 cooperates with the liquid transfer module 4 in transmission. The liquid module 1 is at least used to hold the eluent, the sample liquid module 2 is at least used to hold the sample solution to be processed, the resin column module 6 includes a resin column 6-1, the automatic liquid adding module 3 is at least used to extract the eluent in the eluent module 1 and transport the extracted cleaning liquid to the pipetting module 4; the pipetting module 4 is at least used to inject the eluent into the resin column 6-1, extract the sample solution in the sample liquid module 2 and inject the sample solution into the resin column 6-1, and the sample receiving module 7 is used to receive the liquid flowing out of the resin column module 6.

[0080] In this example, see Figure 2 The eluent module 1 includes a storage cabinet 1-1 and three eluent containers 1-2. The eluent container 1-2 is arranged in the storage cabinet 1-1. The eluent container 1-2 is provided with an eluent output pipeline connector 1-3. The eluent container 1-2 is used to hold eluent. The eluent is generally a highly corrosive chemical reagent (such as concentrated nitric acid, hydrochloric acid, etc.). The eluent container 1-2 is generally a PFA (perfluoroalkoxy vinyl ether copolymer) reagent bottle, which can withstand various highly corrosive chemical reagents. Exemplarily, the three eluent containers 1-2 contain 6 mol / L nitric acid reagent, 0.5 mol / L nitric acid reagent, and 18.2 MΩ / cm ultrapure water, respectively. Of course, the eluent can be configured or replaced according to different isotope processes.

[0081] In this example, see Figure 3The sample liquid module 2 includes a third driving mechanism 2-1, a third screw rod 2-3, a tray, a pipette tip rack 2-4, a sample solution container 2-2, and a pipette tip 4-6. The sample solution container 2-2 and the pipette tip rack 2-4 are sequentially placed on the tray along the x-axis direction of the three-dimensional coordinate system, and the pipette tip 4-6 is placed on the pipette tip rack 2-4. The third driving mechanism 2-1 is connected to the screw rod body of the third screw rod 2-3 by transmission, and the tray is fixedly connected to the screw rod nut of the third screw rod 2-3. The screw rod body of the third screw rod 2-3 extends along the x-axis. The tray can be driven by the third driving mechanism 2-1 to reciprocate along the x-axis together with the sample solution container 2-2 and the pipette tip 4-6. Specifically, the sample liquid module 2 can include twenty sample solution containers 2-2 and twenty pipette tips 4-6, and the sample solution is contained in the sample solution container 2-2. Specifically, the sample solution container 2 - 2 is generally a PFA (perfluoroalkoxy vinyl ether copolymer) reagent cup, and the third driving mechanism 2 - 1 is a rotary driving motor.

[0082] In this example, see Figure 4 and Fig. 9 The automatic liquid adding module 3 includes a first base, a three-way liquid switching solenoid valve 3-1, a first driving mechanism 3-2, a position sensor 3-3, a first screw rod 3-4, an inlet and outlet pipe joint 3-5, a syringe pump 3-6, and a syringe pump push-pull rod 3-7. The three-way liquid switching solenoid valve 3-1, the first driving mechanism 3-2, the position sensor 3-3, the first screw rod 3-4, and the syringe pump 3-6 are assembled on the first base. The three-way liquid switching solenoid valve 3-1 cooperates with the inlet and outlet pipe joint 3-5, and the inlet and outlet pipe joint 3-5 cooperates with the shower The washing liquid container 1-2 and the injection pump 3-6 are controllably connected via the three-way liquid switching solenoid valve 3-1, the first driving mechanism 3-2 is drivingly connected to the screw body of the first screw 3-4, the injection pump push-pull rod 3-7 is fixedly connected to the screw nut of the first screw 3-4 and the piston of the injection pump 3-6, the position sensor 3-3 is used to detect the position of the screw nut of the first screw 3-4, and the position of the piston can be obtained by detecting the position of the screw nut of the first screw 3-4, thereby obtaining the volume of the eluent in the injection pump 3-6. Specifically, the first driving mechanism 3-2 is a rotary drive motor. In this embodiment, the automatic liquid adding module 3 includes three injection pumps 3-6 and three groups of inlet and outlet pipe joints 3-5. The three injection pumps 3-6 are respectively connected to the three washing liquid containers 1-2 via pipelines via three groups of inlet and outlet pipe joints 3-5.

[0083] Specifically, the automatic liquid adding module 3 mainly controls the liquid adding accuracy through the transfer of the syringe pump. First, the push-pull rod of the syringe pump moves downward to absorb the eluent into the cavity of the syringe pump first, switch the solenoid valve, and the push-pull rod of the syringe pump moves upward. The eluent inside the syringe pump is injected into the liquid outlet through the solenoid valve to complete the liquid adding action. The syringe pump can realize the filling of eluent of different capacities through the moving distance of the push-pull rod of the syringe pump, and the repeated liquid adding accuracy is within ±1%.

[0084] In this example, see Figure 5 and Fig. 9 The pipetting module 4 is the core of the system, which is responsible for sample solution loading, eluent addition, and real-time monitoring of the liquid level. The pipetting module 4 includes a second base, a three-way solenoid valve 4-1 for controlling the liquid discharge, a liquid level distance sensor 4-2, a resin column liquid inlet pipe fixture 4-3, an eluent injection tube, a pipetting gun 4-5, and a second motion actuator 4-7. The three-way solenoid valve 4-1 for controlling the liquid discharge, the liquid level distance sensor 4-2, the resin column liquid inlet pipe fixture 4-3, and the second motion actuator 4-7 are assembled on the second base. The eluent injection tube is restricted by the resin column liquid inlet pipe fixture 4-3. 1 is connected to the eluent injection pipe, the liquid outlet control three-way solenoid valve 4-1 is also controllably connected to the inlet and outlet pipe joint 3-5 via the three-way liquid switching solenoid valve 3-1, the second motion actuator 4-7 is in transmission cooperation with the pipette gun 4-5, and is used to drive the pipette gun 4-5 to rise and fall along the z-axis of the three-dimensional coordinate system, so that the pipette gun 4-5 extracts the sample solution in the sample liquid module 2, and injects the sample solution into the resin column 6-1, and the liquid level distance sensor 4-2 is used to detect the liquid level height of the eluent in the resin column 6-1.

[0085] In this embodiment, the second motion actuator 4-7 includes a second drive mechanism and a second screw rod, the second drive mechanism is connected to the screw rod body of the second screw rod, the liquid transfer gun 4-5 is fixedly connected to the screw rod nut of the second screw rod, the screw rod body of the second screw rod extends along the z-axis, and the second drive mechanism is a rotary drive motor. The liquid level ranging sensor 4-2 includes an ultrasonic liquid level ranging sensor. It should be noted that the ultrasonic liquid level ranging sensor is commercially available, and its specific structure and model are not limited here. In this embodiment, the ultrasonic ranging sensor accurately detects the liquid level: the ultrasonic liquid level ranging sensor completes the cyclic detection of twenty groups of resin columns in the system through the cooperation of the ultrasonic ranging sensor and the transfer module. Before and after each liquid addition, the ultrasonic ranging sensor will measure and analyze the liquid level in the resin column. When the liquid level is lower than the set value, the liquid addition of the next process is triggered; when the liquid level is still higher than the set value, the liquid addition continues to wait. Driven by the transfer module, the ultrasonic ranging sensor will cyclically monitor the height of each liquid level, and analyze in real time whether to perform the next step to ensure the smooth progress of the pre-processing process. The liquid level detection repeatability is less than 0.5mm.

[0086] In this embodiment, the pipette 4-5 cooperates with multiple pipette tips 4-6, and the pipette tips 4-6 and the pipette 4-5 can be detachably cooperated. The pipette 4-5 is driven to rise and fall by the second motion actuator 4-7, so that the pipette 4-5 can replace the pipette tips located on the tray. It should be noted that the pipette tip is replaced every time a sample solution is taken to avoid cross contamination between different sample solutions.

[0087] Specifically, by switching the three-way liquid switching solenoid valve 3-1, the eluent container 1-2, the inlet and outlet pipe connector 3-5, the three-way liquid switching solenoid valve 3-1, and the injection pump 3-6, an inlet passage is formed for the eluent to be transported from the eluent container 1-2 to the injection pump 3-6, and the injection pump 3-6, the inlet and outlet pipe connector 3-5, the three-way liquid switching solenoid valve 3-1, the outlet control three-way solenoid valve 4-1, and the eluent injection tube form an outlet passage for the eluent to be injected from the injection pump 3-6 into the resin column 6-1. In this embodiment, the automatic liquid adding module 3 includes multiple inlet and outlet pipe joints 3-5 and multiple injection pumps 3-6, each inlet and outlet pipe joint 3-5 is respectively connected to a washing liquid container 1-2 and a injection pump 3-6, the pipetting module 4 includes multiple liquid outlet control three-way solenoid valves 4-1 and multiple washing liquid injection tubes, and the multiple liquid outlet control three-way solenoid valves 4-1 are respectively connected to the multiple washing liquid injection tubes; multiple liquid inlet passages are formed between the automatic liquid adding module 3 and the washing liquid module 1, and multiple liquid outlet passages are formed between the automatic liquid adding module 3 and the pipetting module 4.

[0088] Specifically, when extracting and injecting the eluent, first switch the three-way liquid switching solenoid valve 3-1 to the liquid inlet, rotate the first drive mechanism 3-2 to drive the screw nut to move downward and pull out the injection pump push-pull rod 3-7, and the eluent enters the injection pump 3-6 from the eluent container 1-2, and then switch the three-way liquid switching solenoid valve 3-1 to the liquid outlet, and the first drive mechanism 3-2 is reversed to drive the screw nut to push the connected injection pump push-pull rod 3-7, so that the eluent is injected into the resin column;

[0089] The eluent added by the injection pump 3-6 is connected to the liquid outlet control three-way solenoid valve 4-1 through the connecting pipeline, and the three-way solenoid valve 4-1 switches the two liquid outlets to achieve the eluent dripping to the two rows of resin columns 6-1;

[0090] After adding the eluent, the pipetting module 4 will patrol back and forth under the drive of the transfer module 5, and detect the height of the eluent level in each resin column 6-1 through the liquid level distance sensor 4-2. When loading the sample solution, the pipette gun 4-5 moves to the position of the sample liquid module 2. The pipette gun 4-5 drives the lifting and lowering drag chain 4-4 to move downward under the action of the second motion actuator 4-7 and absorbs two pipette gun tips 4-6 at the same time. Driven by the third drive mechanism 2-1, the tray is moved out, and the pipette gun 4-5 absorbs the sample solution from the sample solution container 2-2 using the pipette gun tip 4-6. The pipette gun 4-5 rises and moves to the top of the resin column 6-1 to be loaded under the action of the liquid addition and transfer module 5, and the sample solution is added to the resin column 6-1. After the liquid addition is completed, the pipette gun 4-5 moves to the position of the pipette gun tip rack 2-4 and retracts the pipette gun tip 4-6.

[0091] In this embodiment, the pipette 4-5 mainly absorbs the liquid into the pipette head by moving the internal piston upward, and the pipette 4-5 is lifted and moved to the resin column position, and then the piston moves downward to add the liquid in the pipette head to the resin column. The pipette is a customized model adapted to the system, which can absorb two solutions at the same time and add liquid to the front and rear rows of resin columns at the same time. The pipette is quantitative sampling, with a single liquid volume of 1ml and a repeatable pipetting accuracy within ±1%.

[0092] In this example, see Figure 6 The main function of the liquid adding and transferring module 5 is to drive the liquid transfer module 4 to move left and right, so as to achieve the purpose of adding sample solution, eluent, etc. to different resins. Figure 6The liquid adding and transferring module 5 includes a first guide rail, a guide seat 5-3 and a fourth motion actuator. The first guide rail extends along the y-axis of the three-dimensional coordinate system. The guide seat 5-3 is arranged on the first guide rail and cooperates with the first guide rail. The fourth motion actuator includes a fourth driving mechanism 5-1, a synchronous belt 5-2 and a synchronous wheel 5-4. The synchronous wheel 5-4 is mounted on the first guide rail and can rotate. The synchronous belt 5-2 cooperates with the synchronous wheel 5-4 in transmission. The fourth driving mechanism 5-1 cooperates with the synchronous wheel 5-4 in transmission. The guide seat 5-3 is fixedly matched with the synchronous belt 5-2. The fourth motion actuator cooperates with the guide seat 5-3 in transmission and is used to drive the guide seat 5-3 to move on the first guide rail. The liquid transfer module 4 is fixedly mounted on the guide seat 5-3 and moves synchronously with the guide seat 5-3. Specifically, the guide seat 5-3 cooperates with the first guide rail by sliding or rolling. Specifically, the fourth driving mechanism 5-1 and the third driving mechanism are rotation driving mechanisms. Exemplarily, the rotation driving mechanism can be a rotation driving motor or other mechanism that can realize rotational motion output.

[0093] In this example, see Figure 7 The resin column module 6 includes a resin column 6-1 and a fixing seat 6-2. The resin column 6-1 is fixed on the fixing seat 6-2. Resins with different functions are added into the resin 6-1, such as cationic resin AG50W-X8, AG50W-X12, special effect resin IRA 743, etc.

[0094] In this embodiment, the sample receiving module 7 is arranged below the resin column module 6 along the z-axis. The sample receiving module 7 is mainly used to classify and collect the solutions separated by the resin column at different stages. At different stages, the liquid is collected by moving the waste liquid tray back and forth.

[0095] See also Figure 8The sample receiving module includes a sample receiving container, a waste liquid tray 7-2, a fifth motion actuator, a second guide rail 7-6, a lifting platform, a platform lifting bracket 7-5, a sixth motion actuator, a translation platform and a third guide rail 7-8. The translation platform is arranged on the third guide rail 7-8 and can move along the third guide rail 7-8. The platform lifting bracket 7-5 and the sixth motion actuator are fixedly arranged on the translation platform. The lifting platform is fixedly arranged on the platform lifting bracket 7-5. The sixth motion actuator is in transmission cooperation with the platform lifting bracket 7-5 and is used to drive the platform lifting bracket 7-5 to extend and retract along the z-axis of the three-dimensional coordinate system, so that the lifting platform can be lifted and lowered along the z-axis of the three-dimensional coordinate system. The second guide rail 7-6 and the fifth motion actuator are fixedly arranged on the lifting platform. The waste liquid tray 7-2 is arranged on the second guide rail 7-6 and is movably cooperated with the second guide rail 7-6. The fifth motion actuator is in transmission cooperation with the waste liquid tray 7-2 and is used to drive the waste liquid tray 7-2 to move along the second guide rail 7-6. The sample receiving container is placed on the waste liquid tray 7-2. More specifically, the second guide rail 7-6 and the third guide rail 7-8 are both extended along the x-axis of the three-dimensional coordinate system. More specifically, the fifth motion actuator includes a fifth drive mechanism 7-1 and a fifth screw rod, the fifth drive mechanism 7-1 is transmission-connected to the screw rod body of the fifth screw rod, and the waste liquid tray 7-2 is fixedly connected to the screw rod nut of the fifth screw rod.

[0096] Further, the sample receiving module 7 also includes a second guide rail 7-6, the waste liquid tray 7-2 is movably matched with the second guide rail 7-6, and can reciprocate along the second guide rail 7-6 under the drive of the fifth motion actuator, the second guide rail 7-6 extends along the x-axis of the three-dimensional coordinate system, the sixth motion actuator includes a sixth drive mechanism and a sixth screw rod 7-7, the sixth drive mechanism is transmission-connected to the sixth screw rod 7-7, the sixth screw rod 7-7 is transmission-connected to the platform lifting bracket 7-5, and the platform lifting bracket 7-5 is an X-shaped telescopic bracket. More specifically, the sample receiving container can include a large sample receiving cup 7-3, a small sample receiving cup 7-4, etc.

[0097] In this embodiment, the isotope sample preprocessing automation system also includes a control module, which is signal-connected to the automatic liquid adding module 3, the pipetting module 4, the liquid adding and transferring module 5, and the sample receiving module 7, and is at least used to adjust the working status of the automatic liquid adding module 3, the pipetting module 4, the liquid adding and transferring module 5, and the sample receiving module 7.

[0098] It should be noted that the eluent addition method of this embodiment is to accurately control the solution by switching the valve body after the solution is extracted by the syringe pump. The eluent addition can also be achieved by changing the addition method, such as positive pressure addition, negative pressure addition, peristaltic pump addition, etc. In addition to the ultrasonic liquid level sensor used in this embodiment to monitor the liquid level of the resin column in real time, an industrial camera can also be used to detect the liquid level. The method of lateral transfer switching used in this embodiment to complete the transfer of samples and eluent can also be used in a turntable or domino type.

[0099] Example 2

[0100] The method for processing using the isotope sample pre-processing automation system in Example 1 includes the following steps:

[0101] 1) Place ion exchange resins and sieve plates inside 20 resin columns, place the resin columns into the slots of the fixing bases one by one, and place the lower ends of the resin columns into the circular fixing holes on the workbench.

[0102] 2) Place corresponding nitric acid and ultrapure water in the three eluent containers respectively, and place the sample solution container containing the target isotope sample and 20 pipette tips on the tray, and place the large PFA cup and small PFA cup on the waste liquid tray.

[0103] 3) Set the dripping time of each reagent in the controller, and switch to the liquid inlet by controlling the three-way liquid switching solenoid valve, pull out the syringe pump push-pull rod through the motor, and the 6mol / L nitric acid in the eluent container 1 enters the PFA syringe pump ①, and then switch the three-way liquid switching solenoid valve to the liquid outlet, the motor reverses, and pushes the syringe pump push-pull rod in, so that 6mol / L nitric acid is injected into the resin column to clean the resin in the column. Repeat the above process until 6mol / L nitric acid is added to all resin columns.

[0104] 4) The height of the liquid level in each resin column is detected by an ultrasonic liquid level detection sensor. Under the action of gravity, when the 6mol / L nitric acid liquid level drops to the set height, the controller controls the three-way liquid switching solenoid valve to switch to the liquid inlet, and the ultrapure water in the eluent container 2 enters the PFA injection pump ②. The three-way liquid switching solenoid valve is then switched to the liquid outlet, so that the ultrapure water is injected into the resin column to clean the resin again. The above process is repeated until ultrapure water is added to all resin columns.

[0105] 5) Under the real-time monitoring of the ultrasonic liquid level detection sensor, using the effect of gravity, when the ultrapure water level in the resin column drops to the set height, move the pipette to the sample liquid module position and lower it, while sucking up two pipette tips, move the pipette to the sample solution container to suck up two groups of sample solutions, and then rise and move to the left to just above each resin column to add the sample solution into the resin column. After the addition is completed, move the pipette to the right to the pipette tip rack position and retract the pipette tip onto the pipette tip rack.

[0106] 6) The height of the liquid level in each resin column is detected by an ultrasonic liquid level detection sensor. Under the action of gravity, when the liquid level of the sample solution in the resin column drops to the set height, the controller controls the three-way liquid switching solenoid valve to switch to the liquid inlet, and the 0.5mol / L nitric acid in the eluent container 3 enters the PFA injection pump ③, and the three-way liquid switching solenoid valve is switched to the liquid outlet, so that 0.5mol / L nitric acid is injected into the resin column to elute the target isotope Li or Sr, and the above process is repeated until 0.5mol / L nitric acid is added to all resin columns.

[0107] 7) Add appropriate amount of 6 mol / L nitric acid reagent, sample solution and 0.5 mol / L nitric acid reagent to each resin column for gravity elution, and collect the target Li or Sr isotope sample through the PFA sample cup and PFA sample cup during the corresponding elution process.

[0108] 8) After the elution is completed, take away the PFA sample cup and the PFA sample cup, then remove the resin column and store it in a large beaker filled with ultrapure water to prepare for the next elution. Each time you work, the sample cup, sample cup, and pipette tip are all newly processed.

[0109] An isotope sample pretreatment automation system provided in an embodiment of the present invention uses an ultrasonic liquid level continuous detection device to realize real-time monitoring of the liquid level in the resin column, accurately controls the liquid addition time of each process stage in the isotope sample pretreatment, and makes the entire process treatment continuous and accurate, thereby ensuring the accuracy of the treatment process experimental results, and avoiding the problem of poor control of liquid addition time and liquid addition accuracy in current manual sample processing. If the manual liquid addition is not timely, the solution in the resin column will flow out, causing the filler in the column to dry and crack, affecting the subsequent process progress and treatment effect. At the same time, an isotope sample pretreatment automation system provided in an embodiment of the present invention uses an ultrasonic liquid level continuous detection device to realize real-time monitoring of the liquid level in the resin column, which can enable the entire set of automated processing systems to realize intelligent process flow switching, and achieve the purpose of automated and unmanned operation.

[0110] An automated isotope sample pretreatment system provided in an embodiment of the present invention adds liquid through a precision injection pump and uses an ultrasonic ranging sensor to accurately and in real time detect the liquid level in the resin column, thereby realizing full-process automated operation integrating resin purification, sample loading, elution, and target isotope collection in the isotope sample pretreatment process, truly achieving unattended operation, thereby greatly reducing the workload of personnel and improving work efficiency, and bringing a new era of intelligent analysis to the pretreatment of isotope samples.

[0111] It should be understood that the above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. An automated isotope sample pretreatment system, characterized in that: include: An eluent module (1), a sample liquid module (2), an automatic liquid adding module (3), a liquid transfer module (4), a liquid adding and transferring module (5) and a resin column module (6); The automatic liquid adding module (3) is respectively connected to the eluent module (1) and the liquid transfer module (4); the liquid adding and transferring module (5) is in transmission cooperation with the liquid transfer module (4); the liquid adding and transferring module (5) is at least used to drive the liquid transfer module (4) to move along a selected track in an xy plane of a three-dimensional coordinate system; the sample liquid module (2) and the resin column module (6) are located on the selected track; The eluent module (1) is at least used for containing eluent, the sample liquid module (2) is at least used for containing sample solution to be processed, the resin column module (6) comprises a resin column (6-1), the automatic liquid adding module (3) is at least used for extracting eluent in the eluent module (1) and transferring the extracted cleaning solution to the pipetting module (4); the pipetting module (4) is at least used for injecting eluent into the resin column (6-1), extracting sample solution in the sample liquid module (2), and injecting the sample solution into the resin column (6-1).

2. The isotope sample pretreatment automation system according to claim 1, characterized in that: The eluent module (1) comprises an eluent container (1-2); The automatic liquid adding module (3) comprises a three-way liquid switching solenoid valve (3-1), an inlet and outlet pipe joint (3-5), a syringe pump (3-6) and a first motion actuator, the three-way liquid switching solenoid valve (3-1) cooperates with the inlet and outlet pipe joint (3-5), the inlet and outlet pipe joint (3-5) is controllably connected with the eluent container (1-2) and the syringe pump (3-6) via the three-way liquid switching solenoid valve (3-1), and the first motion actuator is connected to the piston of the syringe pump (3-6) in a transmission manner and is used to push and pull the piston; The liquid transfer module (4) comprises a three-way solenoid valve (4-1) for controlling liquid discharge, a washing liquid injection tube, a liquid transfer gun (4-5) and a second motion actuator (4-7). The three-way solenoid valve (4-1) for controlling liquid discharge is connected to the washing liquid injection tube. The three-way solenoid valve (4-1) for controlling liquid discharge is also controllably connected to the inlet and outlet pipe joint (3-5) via the three-way liquid switching solenoid valve (3-1). The second motion actuator (4-7) is in transmission cooperation with the liquid transfer gun (4-5) and is used to drive the liquid transfer gun (4-5) to rise and fall along the z-axis of the three-dimensional coordinate system, so that the liquid transfer gun (4-5) extracts the sample solution in the sample liquid module (2) and injects the sample solution into the resin column (6-1). Wherein, by switching the three-way liquid switching solenoid valve (3-1), the eluent container (1-2), the inlet and outlet pipe joint (3-5), the three-way liquid switching solenoid valve (3-1), and the injection pump (3-6) form an inlet passage for the eluent to be transported from the eluent container (1-2) to the injection pump (3-6), and the injection pump (3-6), the inlet and outlet pipe joint (3-5), the three-way liquid switching solenoid valve (3-1), the outlet control three-way solenoid valve (4-1), and the eluent injection tube form an outlet passage for the eluent to be injected from the injection pump (3-6) into the resin column (6-1); Preferably, the eluent module (1) comprises a plurality of eluent containers (1-2), and the plurality of eluent containers (1-2) are respectively used to contain a plurality of different eluents; The automatic liquid adding module (3) comprises a plurality of inlet and outlet pipe joints (3-5) and a plurality of injection pumps (3-6), and each of the inlet and outlet pipe joints (3-5) is respectively connected to a washing liquid container (1-2) and a injection pump (3-6); The liquid transfer module (4) comprises a plurality of three-way solenoid valves (4-1) for controlling liquid discharge and a plurality of eluent injection tubes, wherein the plurality of three-way solenoid valves (4-1) for controlling liquid discharge are respectively connected to the plurality of eluent injection tubes; A plurality of liquid inlet passages are formed between the automatic liquid adding module (3) and the eluent module (1), and a plurality of liquid outlet passages are formed between the automatic liquid adding module (3) and the liquid transfer module (4).

3. The isotope sample pre-processing automation system according to claim 2, characterized in that: The eluent container (1-2) is provided with an eluent output pipeline connector (1-3), and the eluent output pipeline connector (1-3) is connected to the inlet and outlet pipeline connector (3-5) via a pipeline; Preferably, the eluent module (1) further comprises a storage cabinet (1-1), and the eluent container (1-2) is arranged in the storage cabinet (1-1).

4. The isotope sample pre-processing automation system according to claim 2, characterized in that: The first motion actuator comprises a first driving mechanism (3-2), a first screw rod (3-4), and an injection pump push-pull rod (3-7); the first driving mechanism (3-2) is drivingly connected to the screw rod body of the first screw rod (3-4); the injection pump push-pull rod (3-7) is fixedly connected to the screw rod nut of the first screw rod (3-4) and the piston of the injection pump (3-6); Preferably, the first driving mechanism (3-2) is a rotation driving mechanism; Preferably, the automatic liquid adding module (3) further comprises a position sensor (3-3), wherein the position sensor (3-3) is used to detect the position of the screw nut of the first screw (3-4); Preferably, the automatic liquid adding module (3) further comprises a first base, and the three-way liquid switching solenoid valve (3-1), the injection pump (3-6), and the first motion actuator are assembled on the first base; Preferably, the position sensor (3-3) is mounted on the first base, and the position of the position sensor (3-3) on the first base is adjustable.

5. The isotope sample pre-processing automation system according to claim 2, characterized in that: The second motion actuator (4-7) comprises a second drive mechanism and a second screw rod, the second drive mechanism is transmission-connected to a screw rod body of the second screw rod, the liquid transfer gun (4-5) is fixedly connected to a screw rod nut of the second screw rod, and the screw rod body of the second screw rod extends along the z-axis; Preferably, the second driving mechanism is a rotary driving mechanism; Preferably, the pipette (4-5) cooperates with a plurality of pipette tips (4-6), and the pipette tips (4-6) and the pipette (4-5) can be detachably matched; Preferably, the pipetting module (4) further comprises a resin column liquid adding port pipeline fixing piece (4-3), and the resin column liquid adding port pipeline fixing piece (4-3) is used to limit the eluent injection pipe; Preferably, the liquid transfer module (4) further comprises a liquid level distance measuring sensor (4-2), and the liquid level distance measuring sensor (4-2) is used to detect the liquid level height of the eluent in the resin column (6-1); Preferably, the liquid level distance sensor (4-2) comprises an ultrasonic liquid level distance sensor; Preferably, the pipetting module (4) further comprises a second base, the liquid outlet control three-way solenoid valve (4-1), the pipetting gun (4-5), and the second motion actuator (4-7) are assembled on the second base, and the pipetting gun (4-5) is movably matched with the second base; Preferably, the resin column liquid filling port pipeline fixing member (4-3) is fixedly assembled on the second base; Preferably, the liquid level distance measuring sensor (4-2) is fixedly mounted on the second base.

6. The isotope sample pre-processing automation system according to claim 5, characterized in that: The sample solution module (2) comprises a sample solution container (2-2); Preferably, the sample solution module (2) comprises a plurality of groups of sample solution containers (2-2), the plurality of groups of sample solution containers (2-2) being used to contain different sample solutions, and the sample solution module (2) further comprises a plurality of groups of pipette tips (4-6), each group of pipette tips (4-6) being used to cooperate with the pipette (4-5) to extract the sample solution in a group of sample solution containers (2-2); Preferably, the sample solution module (2) comprises a tray, and the sample solution container (2-2) and the pipette tip (4-6) are placed on the tray; Preferably, the sample solution container (2-2) and the pipette tip (4-6) are placed on the tray in sequence along the x-axis direction of the three-dimensional coordinate system, and the sample solution module (2) further comprises a third motion actuator, the third motion actuator is in transmission cooperation with the tray and is used to drive the tray to reciprocate along the x-axis, and the motion trajectory of the pipetting module (4) is parallel to the y-axis of the three-dimensional coordinate system; Preferably, the third motion actuator comprises a third drive mechanism (2-1) and a third screw rod (2-3), the third drive mechanism (2-1) is transmission-connected to the screw rod body of the third screw rod (2-3), the tray is fixedly connected to the screw rod nut of the third screw rod (2-3), and the screw rod body of the third screw rod (2-3) extends along the x-axis.

7. The isotope sample pre-processing automation system according to claim 1, characterized in that: The liquid adding and transferring module (5) comprises a first guide rail, a guide seat (5-3) and a fourth motion actuator, wherein the guide seat (5-3) is arranged on the first guide rail and is movably matched with the first guide rail, the fourth motion actuator is transmission-matched with the guide seat (5-3) and is used to drive the guide seat (5-3) to move on the first guide rail, and the liquid transfer module (4) is fixedly mounted on the guide seat (5-3) and moves synchronously with the guide seat (5-3); Preferably, the guide seat (5-3) cooperates with the first guide rail by sliding or rolling; Preferably, the fourth motion actuator comprises a fourth drive mechanism (5-1), a synchronous belt (5-2) and a synchronous wheel (5-4), the synchronous wheel (5-4) is mounted on the first guide rail and is rotatable, the synchronous belt (5-2) is in transmission cooperation with the synchronous wheel (5-4), the fourth drive mechanism (5-1) is in transmission cooperation with the synchronous wheel (5-4), and the guide seat (5-3) is fixedly cooperated with the synchronous belt (5-2); Preferably, the fourth driving mechanism (5-1) is a rotation driving mechanism; Preferably, the first guide rail extends along the y-axis of the three-dimensional coordinate system.

8. The isotope sample pre-processing automation system according to claim 1, characterized in that: The resin column module (6) further comprises a fixing seat (6-2), and the resin column (6-1) is fixed on the fixing seat (6-2).

9. The isotope sample pre-processing automation system according to claim 1, characterized in that: Also includes: A sample receiving module (7), the sample receiving module (7) being arranged below the resin column module (6) along the z-axis and being used at least to receive liquid flowing out of the resin column module (6); Preferably, the sample receiving module (7) comprises a sample receiving container; Preferably, the sample receiving module (7) further comprises a fifth motion execution mechanism, the fifth motion execution mechanism being in transmission cooperation with the sample receiving container and being used to drive the sample receiving container to move along the xy plane of the three-dimensional coordinate system; Preferably, the sample receiving module (7) further comprises a waste liquid tray (7-2), the sample receiving container is arranged on the waste liquid tray (7-2), and the fifth motion actuator is in transmission cooperation with the waste liquid tray (7-2) and is used to drive the waste liquid tray (7-2) to move along the x-axis of the three-dimensional coordinate system; Preferably, the fifth motion actuator comprises a fifth drive mechanism (7-1) and a fifth screw rod, the fifth drive mechanism (7-1) is transmission-connected to the screw rod body of the fifth screw rod, and the waste liquid tray (7-2) is fixedly connected to the screw rod nut of the fifth screw rod; Preferably, the sample receiving module (7) further comprises a second guide rail (7-6), the waste liquid tray (7-2) is movably matched with the second guide rail (7-6), and can reciprocate along the second guide rail (7-6) under the drive of the fifth motion actuator, and the second guide rail (7-6) extends along the x-axis of the three-dimensional coordinate system; Preferably, the sample receiving module (7) further comprises a lifting platform, a platform lifting bracket (7-5), and a sixth motion actuator, the lifting platform is fixedly arranged on the platform lifting bracket (7-5), the fifth motion actuator and the second guide rail (7-6) are arranged on the lifting platform, the sixth motion actuator is in transmission cooperation with the platform lifting bracket (7-5), and is used to drive the platform lifting bracket (7-5) to extend and retract along the z-axis of the three-dimensional coordinate system, so that the fifth motion actuator, the second guide rail (7-6) and the lifting platform are synchronously lifted and lowered along the z-axis; Preferably, the sixth motion actuator comprises a sixth drive mechanism and a sixth screw rod (7-7), the sixth drive mechanism is transmission-connected to the sixth screw rod (7-7), the sixth screw rod (7-7) is transmission-connected to the platform lifting bracket (7-5), and the platform lifting bracket (7-5) is an X-shaped telescopic bracket; Preferably, the sample receiving module (7) further comprises a translation platform and a third guide rail (7-8), the translation platform and is arranged on the third guide rail (7-8) and movably cooperates with the third guide rail (7-8), the platform lifting bracket (7-5) and the sixth motion actuator are arranged on the translation platform, the translation platform is arranged on the third guide rail (7-8), and the third guide rail (7-8) extends along the x-axis of the three-dimensional coordinate system.

10. The isotope sample pre-processing automation system according to claim 9, characterized in that: Also includes: A control module, the control module being connected to the automatic liquid adding module (3), the liquid transfer module (4), and the liquid adding and transferring module (5) by signals, and being used at least to adjust the working states of the automatic liquid adding module (3), the liquid transfer module (4), and the liquid adding and transferring module (5); Preferably, the control module is also connected to the sample receiving module (7) by signal, and the control module is also used to adjust the working state of the sample receiving module (7).

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