Ion cloud control method and device, medium and computer equipment

Abstract

The invention provides an ion cloud control method and device, a medium and computer equipment. The method comprises the following steps: receiving an induction electric signal generated on a first electrode; carrying out filtering processing on the induction electric signal; generating an ion cloud control signal based on the filtered induction electric signal; applying an ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole rod system or the multi-pole rod system; by adopting the method provided by the invention, the flight time of the ion cloud in the quadrupole rod can be controlled, the processed pulse signal is amplified and fed back to the control circuit of the outlet electrode of the quadrupole rod, and the signal on the second electrode is utilized to generate an electric field to influence the flight speed of ions in the quadrupole rod system. Therefore, the flight time of each ion is controlled at the same length as much as possible, the number of single particles or single cells which can be distinguished and analyzed in unit time is increased while ion movement is more accurately controlled, and the flux of single particle or single cell analysis is greatly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of particle analysis, and more specifically, to an ion cloud control method, device, medium and computer equipment. Background Art

[0002] The present invention relates to the fields of analytical chemistry, mass spectrometry and instrument control, and in particular to ion cloud dynamic control and interference suppression technology in inductively coupled plasma mass spectrometry (ICP-MS). The present invention also relates to improving the performance of ICP-MS in rapid transient signal analysis, single particle / single cell detection and combination with other separation technologies.

[0003] Inductively coupled plasma mass spectrometry (ICP-MS) is a highly sensitive elemental analysis technique, but it faces the challenges of interfering elements and matrix effects in complex samples. Methods such as collision / reaction cell technology and high-resolution mass spectrometry can partially solve the interference problem, but often at the expense of sensitivity or increased complexity. Existing technologies such as multi-collector ICP-MS (MC-ICP-MS) have made significant progress in high-precision isotope analysis, but still have limitations in processing fast transient signals. Existing technologies may be able to suppress interference from low-concentration signals through more complex structural design, electrical system design, and data processing algorithms, but they have not been able to solve the suppression of the background argon ion peak and its adduct peak inherent in ICP-MS.

[0004] In addition, with the increasing demand for combining ICP-MS with separation technologies such as chromatography and electrophoresis, especially for transient ion clusters such as single particles and single cells, the demand for fast and precise control of ion transmission has become more urgent. The existing technology cannot adjust the time length of the ion cloud, resulting in a limited number of single particles or cells that can be analyzed per unit time, which greatly reduces the analysis throughput. Summary of the invention

[0005] In view of the shortcomings of the prior art, the purpose of the present invention is to provide an ion cloud control method, device, medium and computer equipment to overcome the shortcomings of the prior art that the flight time of the ion cloud cannot be adjusted, resulting in a limited number of single particles or single cells that can be distinguished and analyzed per unit time and a reduced analysis throughput.

[0006] The above technical objectives of the present invention are achieved through the following technical solutions: an ion cloud control method, applied to a rod-type mass analyzer; the rod-type mass analyzer comprises: a quadrupole system or a multipole system, a first electrode and a second electrode; the first electrode is arranged at the input end of the quadrupole system or the multipole system; the second electrode is arranged at the output end of the quadrupole system or the multipole system;

[0007] The ion cloud control method comprises:

[0008] In response to the input of the ion cloud, receiving an induced electrical signal generated on the first electrode;

[0009] Performing filtering processing on the induced electrical signal;

[0010] Based on the filtered induced electrical signal, an ion cloud control signal is generated;

[0011] The ion cloud control signal is applied to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0012] In one embodiment, the filtering the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0013] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out a portion of the induced electrical signal with a frequency of more than 2 kHz to obtain a filtered induced electrical signal.

[0014] In one embodiment, the ion cloud control signal is specifically a square wave.

[0015] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge changes linearly.

[0016] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0017]

[0018] Among them, t 1 Indicates the starting time of the rising edge of the square wave signal; t 2 Indicates the end time of the rising edge of the square wave signal; v 2 Indicates the pulse amplitude of the basic square wave; v 1 Represents the basic exponential function pulse amplitude.

[0019] In one embodiment, the ion cloud consists of a plurality of ions;

[0020] The movement time is specifically: the movement time of each ion in the ion cloud is between 47 μs and 53 μs.

[0021] An ion cloud control device, comprising:

[0022] A receiving unit, configured to receive an induced electrical signal generated on the first electrode in response to an input of an ion cloud;

[0023] A filtering unit, used for filtering the induced electrical signal;

[0024] A generating unit, used for generating an ion cloud control signal based on the filtered induced electrical signal;

[0025] An adjustment unit is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0026] A computer-readable storage medium stores a computer program, which implements the steps of the above method when executed by a processor.

[0027] A computer device comprises a memory and a processor, wherein the memory stores a computer program, and the processor implements the steps of the above method when executing the computer program.

[0028] In summary, the present invention has the following beneficial effects: an ion cloud control method, comprising: receiving an induced electrical signal generated on the first electrode in response to an ion cloud input; filtering the induced electrical signal; generating an ion cloud control signal based on the induced electrical signal after filtering; applying the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system; using the method of the present invention, the flight time of the ion cloud in the quadrupole can be controlled, the processed pulse signal can be amplified and fed back to the control circuit of the multipole exit electrode, and the signal on the second electrode can be used to generate an electric field to affect the flight speed of ions in the quadrupole system, thereby making the flight time of each ion as controlled as possible within the same length, while more accurately controlling the movement of ions, increasing the number of single particles or single cells that can be resolved and analyzed per unit time, thereby greatly improving the throughput of single particle or single cell analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a flow chart of an ion cloud control method of the present invention;

[0030] Figure 2 is a structural diagram of an ion cloud control device in an embodiment of the present invention;

[0031] Figure 3 is an internal structure diagram of a computer device in an embodiment of the present invention;

[0032] Figure 4 A diagram showing the structure of a quadrupole system and an electrode sheet combination in an embodiment of the present invention;

[0033] Figure 5 is a schematic diagram of a voltage variation curve in an embodiment of the present invention;

[0034] In the figure, 1, receiving unit; 2, filtering unit; 3, generating unit; 4, adjusting unit; 101, ion source; 102, ion cloud; 400, quadrupole system; 401, entrance electrode; 402, quadrupole; 403, exit electrode. DETAILED DESCRIPTION

[0035] In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings. Several embodiments of the present invention are shown in the accompanying drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein.

[0036] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal connection of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. The terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features.

[0037] In the present invention, unless otherwise clearly specified and limited, the first feature being "above" or "below" the second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Moreover, the first feature being "above", "above" and "above" the second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature includes the first feature being directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature. The terms "vertical", "horizontal", "left", "right", "above", "below" and similar expressions are for illustrative purposes only, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0038] The present invention is described in detail below in conjunction with the accompanying drawings and embodiments. In order to facilitate the understanding of the embodiments, the related art is first described. The quadrupole mass spectrometer controls the movement of ions by applying an alternating electric field. Only ions that meet a specific mass-to-charge ratio (m / z) range can pass through the quadrupole to reach the detector. Ions of other masses will be deflected or lose stability and thus be excluded. This selective ion transmission mechanism can achieve higher resolution. By accurately adjusting the frequency of the alternating electric field, it is possible to ensure that ions of different mass-to-charge ratios pass through the quadrupole within a set time period. This method of controlling the ion flight time can simultaneously process multiple ion populations and ensure that each ion population passes through the detector in a different time window. In single-particle or single-cell analysis, it is usually necessary to analyze very small sample amounts, and the instantaneous signal intensity of these samples is low. Therefore, precise control of the flight time can quickly analyze these trace samples and reduce sample loss. The quadrupole can also optimize the flight time to achieve simultaneous analysis of ions of multiple masses, which greatly increases the number of ions that can be processed in a single run. High-throughput analysis requires processing a large number of samples in a short time and performing detailed analysis on each sample at the same time. By controlling the flight time of ions, the quadrupole can analyze multiple ion signals per unit time, reducing the time required for a single analysis. However, when there are a large number of ions, using only the quadrupole to control the flight time of ions cannot meet the high-throughput requirements of fast instantaneous signal analysis.

[0039] Embodiment 1

[0040] In order to solve the above problems, the present invention provides an ion cloud control method, such as Figure 1 As shown, it is applied to a rod-type mass analyzer; the rod-type mass analyzer comprises: a quadrupole system or a multipole system, a first electrode and a second electrode; the first electrode is arranged at the input end of the quadrupole system or the multipole system; the second electrode is arranged at the output end of the quadrupole system or the multipole system;

[0041] The ion cloud control method comprises:

[0042] S1, in response to the input of the ion cloud, receiving the induced electrical signal generated on the first electrode;

[0043] S2, filtering the induced electrical signal;

[0044] S3, generating an ion cloud control signal based on the filtered induced electrical signal;

[0045] S4. Applying the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0046] In practical applications, such as Figure 4 As shown, firstly, it is necessary to set a first electrode at the input end of the quadrupole system. When the ion cloud enters the quadrupole system, an induced electrical signal will be generated on the first electrode. When the number of ions passing through is large, the intensity of the induced electrical signal is large, and when the number of ions passing through is small, the intensity of the induced electrical signal is small. Therefore, by receiving the induced electrical signal generated on the first electrode, the intensity and time distribution of the ion cloud can be reflected. Due to the inherent time length of the ion cloud in ICP-MS (inductively coupled plasma mass spectrometry), the frequency of the generated pulse signal will not exceed 2kHz, so other common mode or conducted high-frequency interferences should be filtered out. Then the signal strength is enhanced by an amplifying circuit to improve the accuracy of subsequent processing. The control device generates a corresponding control signal based on signal control. First, the analog signal peak shape is identified by the signal acquisition system, and the time length information is analyzed by a fast peak search algorithm, such as a 3-point peak search algorithm. Through the information of time length, a voltage pulse peak with adjustable rise time can be preset, and finally this voltage pulse peak is applied to the second electrode. After the voltage pulse peak is applied to the electrode, the electric field generated by the second electrode can be used to control the flight speed of the ion cloud in the quadrupole system, so that the flight speed of the ion cloud can be maintained at the same time length as much as possible. By controlling the flight speed of the ion cloud, the number of ions that can be processed in a single run is increased, and the throughput of single particle or single cell analysis of the quadrupole system is improved. The method of this patent is particularly outstanding in the analysis of fast transient signals, meeting the needs of high-throughput analysis.

[0047] In one embodiment, the filtering the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0048] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out a portion of the induced electrical signal with a frequency of more than 2 kHz to obtain a filtered induced electrical signal.

[0049] In practical applications, in ICP-MS (inductively coupled plasma mass spectrometry), the sample is atomized and ionized by plasma to produce an "ion cloud" composed of ions. The process of these ions staying in the plasma and transmitting to the detector has a certain time limit, which is called the "intrinsic time length". This time length is determined by the plasma source, the sample spray process, the ionization efficiency, and the speed of the ions passing through the mass spectrometer. Due to certain delays and physical limitations in the generation and transmission of the ion cloud, the frequency of the generated signal (that is, the pulse signal of the ion) will not be too high, usually below 2kHz. This means that up to 2000 ion signal peaks can be detected per second. Although the pulse signal frequency generated by the ion cloud is low, there will be other high-frequency noise or interference signals in the ICP-MS system, including common-mode interference and conducted interference. Common-mode interference is an electrical interference, usually caused by the power supply or the external circuit of the system. The interference signal may appear synchronously in different parts of the system, affecting the entire circuit. Conducted interference is a high-frequency interference conducted through wires or circuits, usually from power supplies, motors or other electrical equipment, affecting the measurement of the instrument. The frequency of these interferences is usually much higher than 2kHz, even reaching tens of kilohertz or higher. Therefore, although the frequency of the ion cloud signal will not exceed 2kHz, high-frequency common-mode or conducted interference may still affect the measurement accuracy and needs to be filtered out.

[0050] In one embodiment, the ion cloud control signal is specifically a square wave.

[0051] In practical applications, the clear on-off state of the square wave signal can accurately control the duration of the ion cloud. In a quadrupole system, the flight time of the ion cloud can be accurately adjusted by adjusting the frequency and duty cycle of the square wave signal, so that the system can better adapt to different ion characteristics, thereby improving the accuracy and sensitivity of the analysis. The modulation capability of the square wave signal enables the system to perform dynamic voltage control, including square wave generation, modulation, and pulse width adjustment. This enhances the dynamic control capability of the system, allowing flexible adjustments under different operating conditions to meet the needs of fast transient signal analysis.

[0052] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge changes linearly.

[0053] In practical applications, the sharp rising edge of the square wave will produce strong electromagnetic interference. Changing the rising edge to a linear boost can significantly reduce electromagnetic interference, because the linear transition signal changes more smoothly and reduces the generation of high-frequency noise. The sharp transition of the square wave will cause switching noise, and the linear boost makes the switching process smoother, thereby reducing the amplitude of the noise and improving the signal quality and stability of the system. The linear rising edge can make the signal transition smoother and avoid the instability caused by sharp changes. The smooth transition helps to reduce overshoot and ringing in analog and digital circuits, and improve the reliability and consistency of the signal. The signal with a linear rising edge is more compatible with other circuits and systems, reduces the sensitivity to high-frequency interference, and improves the adaptability and stability of the system.

[0054] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0055]

[0056] Among them, t 1 Indicates the starting time of the rising edge of the square wave signal; t 2 Indicates the end time of the rising edge of the square wave signal; v 2 Indicates the pulse amplitude of the basic square wave; v 1 Represents the basic exponential function pulse amplitude.

[0057] In actual applications, particulate matter (the object to be detected) is ionized by a laser in the center of the extraction zone, and the generated positive and negative ions are then accelerated in opposite directions in the acceleration zone. Ions of different masses will be accelerated to different speeds under the action of the electric field. After the acceleration is completed, they are detected by two mass analyzers respectively. Therefore, the charge-to-mass ratio of the ions can be calculated based on the flight time of the ions. When the object to be detected is ionized into ions, an explosion often occurs, so that the positive and negative ions formed have a larger initial velocity, and the velocities of ions of the same mass are often different, thereby affecting the resolution of the online aerosol mass spectrometer. The prior Chinese patent application (application number: CN201810149729.3) proposed a method to improve the resolution of the mass spectrometer by changing the voltage parameters on the extraction electrode, such as Figure 5As shown, by changing the voltage parameter of the extraction zone from the traditional DC voltage to the pulse voltage, the influence of the initial velocity of the object to be detected on the detection accuracy can be effectively reduced. Specifically, the DC voltage on the extraction electrode is changed to a pulse voltage, and the low-level time length of the pulse voltage is the waiting time after the particle is ionized. The specific meaning of the waiting time is to wait for the kinetic energy generated by the ions after the explosion to be consumed, so that the movement of ions of various masses tends to be stable, and then the pulse voltage is adjusted to a high level, so that the ions in the extraction zone can be pulled into the acceleration zone by the electric field of the extraction zone when the motion state is close. Thereby, the time for ions of the same mass to enter the acceleration zone and reach the detector is basically the same, which effectively improves the resolution of the mass spectrometer. The application also discloses the use of the following incremental extraction electrode voltage adjustment function to calculate the target voltage value that changes continuously within the preset ion flight time range:

[0058]

[0059] Wherein, V represents the target voltage value, V 1 is the pulse amplitude of the square wave function, V 2 (t) represents the exponential function, t represents the variable of ion flight time, t 1 represents the waiting time after laser ionization, t 2 represents the exponential pulse rise time, t 3 represents the time after the pulse stabilizes, v 2 represents the pulse amplitude of the exponential function. Therefore, based on this patent, the rising edge of the square wave signal used to control the ion cloud in this application can also be adjusted based on the control signal. That is, the rising edge of the square wave signal is adjusted according to the following equation:

[0060]

[0061] Among them, t 1 Indicates the starting time of the rising edge of the square wave signal; t 2 Indicates the end time of the rising edge of the square wave signal; v 2 Indicates the pulse amplitude of the basic square wave; v 1 Represents the basic exponential function pulse amplitude.

[0062] In one embodiment, the ion cloud is composed of a plurality of ions; the movement time is specifically: the movement time of each ion in the ion cloud is between 47 μs and 53 μs.

[0063] In one embodiment, the quadrupole RF system is powered in accordance with the following equation:

[0064]

[0065] Among them, U represents the DC voltage; V represents the amplitude of the main AC voltage; ω represents the angular frequency of the main AC voltage; V aux Indicates the amplitude of the auxiliary AC voltage; ω aux is the angular frequency of the auxiliary AC voltage.

[0066] Among them, the relationship between the auxiliary angular frequency and the main angular frequency satisfies:

[0067] ω auxt =β×ω;

[0068] β is a coefficient that satisfies the following equation:

[0069]

[0070] Where a represents a stability parameter related to the DC voltage in the quadrupole system, which is used to describe the stability range of ions in the quadrupole electric field; in the stability diagram of the quadrupole mass spectrometer, parameter a determines the effect of the DC electric field on the ions. According to the quadrupole equation, parameter a is usually proportional to the DC voltage U applied to the quadrupole. Parameter q is usually a stability parameter related to the AC voltage in the quadrupole system, which is used to describe the stability range of ions in the AC electric field (RF field). Parameter q is usually related to the AC voltage V and AC frequency ω applied to the quadrupole. The value of parameter q determines the stability of ions of different masses in the electric field and their ability to pass through the quadrupole.

[0071] Embodiment 2

[0072] See also Figure 2 , an ion cloud control device, the ion cloud control device comprising:

[0073] A receiving unit 1, configured to receive an induced electrical signal generated on the first electrode in response to an input of an ion cloud;

[0074] A filter unit 2, used for filtering the induced electrical signal;

[0075] A generating unit 3, used for generating an ion cloud control signal based on the filtered induced electrical signal;

[0076] The adjustment unit 4 is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0077] For the specific definition of the ion cloud control device, please refer to the definition of the ion cloud control method above, which will not be repeated here. The various modules in the above-mentioned ion cloud control device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory in the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.

[0078] Those skilled in the art will understand that Figure 2 The structure shown in the figure is only a block diagram of a part of the structure related to the present application scheme, and does not constitute a limitation of the present application scheme. The specific ion cloud control device may include more or fewer components than those shown in the figure, or combine certain components, or have a different component arrangement.

[0079] Embodiment 3

[0080] A computer-readable storage medium stores a computer program, which, when executed by a processor, implements the ion cloud control method as described in Example 1.

[0081] Embodiment 4

[0082] In one embodiment, a computer device is provided. The computer device may be a server, and its internal structure diagram may be as follows: Figure 3 As shown. The computer device includes a processor, a memory, a network interface and a database connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. When the computer program is executed by the processor, an ion cloud control method is implemented.

[0083] Those skilled in the art will understand that Figure 3 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0084] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the following steps when executing the computer program: applied to a rod-type mass analyzer; the rod-type mass analyzer includes: a quadrupole system or a multipole system, a first electrode and a second electrode; the first electrode is arranged at the input end of the quadrupole system or the multipole system; the second electrode is arranged at the output end of the quadrupole system or the multipole system;

[0085] The ion cloud control method comprises:

[0086] In response to the input of the ion cloud, receiving an induced electrical signal generated on the first electrode;

[0087] Performing filtering processing on the induced electrical signal;

[0088] Based on the filtered induced electrical signal, an ion cloud control signal is generated;

[0089] The ion cloud control signal is applied to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

[0090] In one embodiment, the filtering the induced electrical signal specifically includes: performing low-pass filtering on the induced electrical signal.

[0091] In one embodiment, the low-pass filtering of the induced electrical signal specifically includes: filtering out a portion of the induced electrical signal with a frequency of more than 2 kHz to obtain a filtered induced electrical signal.

[0092] In one embodiment, the ion cloud control signal is specifically a square wave.

[0093] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge changes linearly.

[0094] In one embodiment, the ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation:

[0095]

[0096] Among them, t 1 Indicates the starting time of the rising edge of the square wave signal; t 2 Indicates the end time of the rising edge of the square wave signal; v 2 Indicates the pulse amplitude of the basic square wave; v 1 Represents the basic exponential function pulse amplitude.

[0097] In one embodiment, applying the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system specifically includes: the movement time of each ion in the ion cloud is between 47 μs and 53 μs.

[0098] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

[0099] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. An ion cloud control method, characterized in that: Applicable to a rod-type mass analyzer; the rod-type mass analyzer comprises: a quadrupole system or a multipole system, a first electrode and a second electrode; the first electrode is arranged at the input end of the quadrupole system or the multipole system; the second electrode is arranged at the output end of the quadrupole system or the multipole system; The ion cloud control method comprises: In response to the input of the ion cloud, receiving an induced electrical signal generated on the first electrode; Performing filtering processing on the induced electrical signal; Based on the filtered induced electrical signal, an ion cloud control signal is generated; The ion cloud control signal is applied to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

2. The ion cloud control method according to claim 1, characterized in that: The filtering process on the induced electrical signal specifically includes: performing low-pass filtering process on the induced electrical signal.

3. The ion cloud control method according to claim 2, characterized in that: The low-pass filtering of the induced electrical signal specifically includes: filtering out a portion of the induced electrical signal above 2 kHz to obtain a filtered induced electrical signal.

4. The ion cloud control method according to claim 3, characterized in that: The ion cloud control signal is specifically a square wave.

5. The ion cloud control method according to claim 3, characterized in that: The ion cloud control signal is specifically a square wave signal whose rising edge changes linearly.

6. The ion cloud control method according to claim 3, characterized in that: The ion cloud control signal is specifically a square wave signal whose rising edge satisfies the following equation: Among them, t1 represents the starting time of the rising edge of the square wave signal; t2 represents the ending time of the rising edge of the square wave signal; v2 represents the pulse amplitude of the basic square wave; v1 represents the pulse amplitude of the basic exponential function.

7. The ion cloud control method according to claim 1, characterized in that: The ion cloud is composed of a number of ions; The movement time is specifically: the movement time of each ion in the ion cloud is between 47 μs and 53 μs.

8. An ion cloud control device, characterized in that: The ion cloud control device comprises: A receiving unit, configured to receive an induced electrical signal generated on the first electrode in response to an input of an ion cloud; A filtering unit, used for filtering the induced electrical signal; A generating unit, used for generating an ion cloud control signal based on the filtered induced electrical signal; An adjustment unit is used to apply the ion cloud control signal to the second electrode to adjust the movement time of the ion cloud in the quadrupole system or the multipole system.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the ion cloud control method as described in any one of claims 1 to 7 is implemented.

10. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the ion cloud control method as described in any one of claims 1 to 7 is implemented.

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