Chinese and western composite powder helpful for clearing damp and reducing fat and preparation method thereof

Abstract

According to the Chinese and western composite powder helpful for clearing damp and reducing fat and the preparation method thereof, bifidobacterium breve B-3, the white kidney bean extract and the vitamin B synergistically obstruct carbon water, EGCG and the vitamin B synergistically inhibit fat synthesis, the bifidobacterium breve B-3 decomposes fat and reduces fat accumulation, the four substances act on different targets to directly interfere metabolism, and therefore the Chinese and western composite powder helpful for clearing damp and reducing fat is obtained. According to the traditional Chinese medicine composition, the effects of reducing weight and fat can be achieved in a short time, the constitution of obese people with qi deficiency, phlegm dampness or comprehensive constitution is improved from the mechanism of tonifying qi, promoting the circulation of qi and promoting diuresis, and the problems that the metabolic function of the body is affected by dampness, energy consumption is reduced, and fat is easily accumulated are solved from the source. All the components in the Chinese and western are mutually cooperated, dampness can be effectively removed, fat and weight are reduced in a non-motion and non-energy control mode, and meanwhile the problem that people easily rebound after weight loss is solved.

Description

Technical Field

[0001] The present invention relates to the field of fat-reducing products, and particularly to a Chinese and Western compound powder helpful for dispelling dampness and reducing fat and a preparation method thereof. Background Art

[0002] According to statistics, the proportion of overweight and obese people in the world exceeds 30%, and the development speed of obesity is worrying. Especially in developed countries, the problem of weight loss has received unprecedented attention. The harms brought by obesity are far more than just the distortion of body shape. A series of health problems caused by it are seriously threatening human life and health. Medical research shows that obesity is one of the main inducements of type II diabetes, and about 90% of type II diabetes patients were overweight before getting the disease. At the same time, the risk of hypertension in obese people is 2-3 times higher than that of people with normal weight. More worryingly, obesity is closely related to various cancers, such as breast cancer, colorectal cancer, endometrial cancer, etc. The International Agency for Research on Cancer (IARC) research points out that obesity causes hundreds of thousands of new cancer cases globally every year. For this reason, obesity is recognized as one of the main killers of human health in the 21st century.

[0003] Facing such a severe obesity situation, the public's demand for weight loss and fat reduction is increasing day by day, which also promotes the emergence of numerous weight loss and fat reduction products on the market. However, most of the current weight loss and fat reduction products on the market are intervened based on the formula for prolonging satiety, adsorbing grease, and promoting gastrointestinal peristalsis. This kind of formula often has time sensitivity, that is, it can only achieve weight loss and fat reduction effects in a short time and cannot achieve long-term effectiveness. Most formulas do not have a long-term improvement effect on people with the problem of heavy dampness. These components do not first reconcile the constitution basis of spleen deficiency and dampness accumulation in the problem body and then improve obesity. As a result, even if short-term weight loss is achieved through some Western-style weight loss components, weight rebound will still occur due to the accumulation of metabolic wastes (such as phlegm dampness obstructing the interior). For example, a weight loss composition, food preparation, and application for inhibiting fat absorption disclosed in CN118452451B achieve weight loss by inhibiting fat absorption, but it has short-term time limitation and cannot fundamentally solve the obesity problem of obese people with heavy dampness. Another example is that Chinese patent application CN114424825B discloses a five-fold fat-reducing composition and its preparation method and application, which uses white kidney bean extract, double mushroom concentrated powder, medium-chain triglyceride microcapsule powder, and potato extract, and also compounded "medicinal and edible homologous" substances such as kudzu root, cassia seed, radish seed, and hawthorn, improving the fat-blocking and lipid-lowering efficacy of the composition, but it does not clarify the suitable population of constitution and does not track the long-term effect.

[0004] Of course, there are also some prescriptions for drugs for dispelling dampness and health care teas for dispelling dampness on the market. However, most of them are based on the principle of strengthening diuresis and promoting excretion, without considering supplementing qi. After long-term use of such prescriptions, it may damage qi and may aggravate the symptoms of patients with deficiency of qi or yang deficiency type obesity. For example, CN104587311B discloses a traditional Chinese medicine extract for strengthening the spleen and dispelling dampness, its preparation method, application and paste for strengthening the spleen and dispelling dampness. With Poria cocos as the monarch drug, the prescription focuses more on strengthening the spleen, promoting digestion and removing dampness, but lacks the driving force of qi movement, and the physical fitness indications are different.

[0005] In other words, there is a lack of weight loss and fat loss products on the market that can fundamentally solve the obesity problem of obese people with heavy dampness and have a long-term weight loss effect. Summary of the Invention

[0006] The purpose of the present invention is to provide a traditional Chinese and Western compound powder that helps to dispel dampness and reduce fat, and its preparation method. The western medicine components achieve fat loss in a multi-channel synergistic manner, and the traditional Chinese medicine components regulate the physique of obese people by promoting metabolism with qi supplementation. The two work together synergistically to effectively dispel dampness, reduce fat and weight loss for obese people with qi deficiency, phlegm-dampness or comprehensive physique, achieve non-exercise and non-energy control fat loss, and at the same time solve the problem of easy rebound after weight loss.

[0007] To achieve the above purpose, in the first aspect, the present technical solution provides a traditional Chinese and Western compound powder that helps to dispel dampness and reduce fat, including:

[0008] Bifidobacterium breve B-3, vitamin B, spray granule and nano-SiO 2 - magnesium stearate double-coated powder;

[0009] The spray granule is obtained from a pre-mixed powder by spraying a low oligosaccharide solution. The pre-mixed powder includes a mixed cranberry fruit powder, coix seed extract powder, Poria cocos extract powder, Astragalus membranaceus extract powder, tangerine peel extract powder, Chinese yam extract powder, Amomum villosum extract powder, white kidney bean extract and EGCG;

[0010] Nano-SiO 2 - magnesium stearate double-coated powder is a low molecular weight xylo-oligosaccharide-xylitol co-crystalline powder double-coated by nano-SiO 2 and magnesium stearate.

[0011] It should be noted that the traditional Chinese and Western compound powder provided in this solution that helps to dispel dampness and reduce fat is specifically for obese people with qi deficiency, phlegm-dampness or comprehensive physique.

[0012] For people with Qi deficiency, when the human body is in a state of Qi deficiency, the driving function of Qi decreases, and the body's metabolic rate slows down. This means that the decomposition, transportation and consumption of substances such as fat in the body are hindered, and they cannot be converted into energy and excreted from the body as efficiently as normal. Over time, fat gradually accumulates, leading to weight gain and obesity. Qi deficiency often affects the spleen and stomach, weakening the spleen and stomach's ability to transport and transform. The spleen and stomach cannot fully digest and absorb the nutrients in food, resulting in some nutrients not being effectively utilized. Instead, they stagnate in the body, forming phlegm and dampness or converting into fat and accumulating. For people with phlegm and dampness, dampness is the "root of all evil". Dampness often first traps the spleen yang, thereby affecting the spleen's transportation and transformation and the rise and fall of Qi. When the spleen fails to transport and transform, water and dampness stagnate inside, and fat and fat accumulate, it is easy to develop into obesity. In other words, phlegm and dampness in the body will not only affect water metabolism, but also block the movement of Qi. When the Qi is blocked by phlegm and dampness, Qi and blood do not flow smoothly, and the internal organs cannot get enough Qi and blood nourishment. , the function further declines, which will lead to a decrease in the body's energy consumption, a decrease in fat decomposition and metabolism, and the excess energy cannot be consumed in time, and can only be stored in the form of fat, which leads to weight gain and obesity. Therefore, for obese people with qi deficiency, phlegm-dampness or comprehensive constitution, replenishing qi to promote metabolism is the method itself, and the Chinese medicine components in the Chinese and Western composite powder provided in this scheme are based on the structure of replenishing qi-promoting qi-eliminating dampness to achieve dampness removal and qi replenishment, thereby fundamentally solving the physical problems of obese people with qi deficiency, phlegm-dampness or comprehensive constitution. However, if only Chinese medicine components are used to regulate physical constitution, there is a problem of slow effect. Therefore, the Chinese and Western composite powder provided in this scheme that helps to remove dampness and reduce fat is also compounded with Western medicine components to quickly achieve non-exercise, non-pure energy controlled fat reduction from multiple pathways.

[0013] The Chinese and Western composite powder provided in this plan helps to remove dampness and reduce fat. The Bifidobacterium breve B-3, white kidney bean extract, and vitamin B work together to block carbohydrates, EGCG and vitamin B work together to inhibit fat synthesis, Bifidobacterium breve B-3 directly breaks down fat and reduces fat accumulation, and the coix seed extract powder, Poria extract powder, Astragalus extract powder, tangerine peel extract powder, yam extract powder, and Amomum villosum extract powder work together to remove dampness.

[0014] About blocking the pathway of weight loss and fat loss by blocking carbohydrates:

[0015] As a natural amylase inhibitor, white kidney bean extract plays a core role in carbon water interception. Amylase in the human digestive system is responsible for breaking down large molecular starch into small molecular sugars for human absorption and utilization. White kidney bean extract can specifically bind to amylase and interfere with its active site, thereby preventing amylase from breaking down starch. Studies have shown that it can intercept up to 66% of carbon water absorption, reducing the total amount of carbohydrates entering the human body from the source and reducing the risk of excess carbon water being converted into fat.

[0016] As a probiotic, Bifidobacterium breve B-3 not only plays an important role in maintaining intestinal health, but also has a unique synergistic effect on the process of carbohydrate absorption blockage. It can enhance the inhibitory activity of white kidney bean extract through multiple pathways. On the one hand, the metabolites of Bifidobacterium breve B-3 in the intestine may affect the pH value, osmotic pressure, etc. of the intestinal environment. These changes in the microenvironment are conducive to the better binding of white kidney bean extract to amylase, thereby enhancing its inhibitory effect; on the other hand, Bifidobacterium breve B-3 may indirectly enhance the inhibitory effect of white kidney bean extract on amylase by regulating the function of intestinal epithelial cells and affecting the distribution and activity of amylase in the intestine.

[0017] The B vitamins are involved in human glucose metabolism, accelerating the metabolic process and reducing carbohydrate intake.

[0018] Regarding the weight loss and fat reduction pathway of inhibiting fat synthesis:

[0019] EGCG is a natural polyphenolic compound with the ability to inhibit lipase activity, thereby reducing the breakdown and absorption of fat. There is a specific interaction mode between the molecular structure of vitamin B and EGCG. Through the formation of n-n stacking and hydrogen bonds, the two can bind tightly together. This binding makes the complex formed by EGCG and lipase more stable in spatial conformation, like putting a "lock" on the complex, making it difficult to dissociate, thus enhancing the occupation and inhibitory effect of EGCG on the active site of lipase. In addition, vitamin B also strengthens the function of EGCG through the redox cycling mechanism. In cells, vitamin B can be converted into flavin adenine dinucleotide (FAD). After accepting electrons, FAD forms FADH. FADH can participate in the regeneration process of EGCG. When EGCG loses its activity due to oxidation during the process of inhibiting lipase activity, FADH can provide electrons to reduce the oxidized EGCG to an active form, enabling it to continuously play the role of inhibiting lipase. This redox cycle greatly prolongs the effective action time of EGCG in the body and further enhances its inhibitory effect on fat synthesis, that is, vitamin B enhances the efficacy of EGCG in inhibiting fat synthesis through a unique dual mechanism.

[0020] Regarding the weight loss and fat reduction pathway of reducing fat accumulation:

[0021] Bifidobacterium breve B-3 can promote β-oxidation, which is a key pathway for fat catabolism. In the liver, Bifidobacterium breve B-3 accelerates the β-oxidation process of fatty acids by regulating the activities of a series of enzymes related to β-oxidation, breaking down fats into acetyl-CoA, thereby providing energy for cells and reducing fat accumulation in the liver. At the same time, Bifidobacterium breve B-3 can also reduce visceral fat and inhibit fat accumulation in adipose tissue, and its mechanism of action is mainly achieved by regulating the metabolism and endocrine function of adipocytes.

[0022] Regarding the weight loss and fat loss pathway of removing dampness:

[0023] Traditional Chinese medicine components follow the principle of "sovereign - minister - assistant - courier". Among them, astragalus extract powder and yam extract powder are used as the "sovereign drugs". Astragalus extract powder can tonify qi and lift yang, and promote diuresis and resolve edema for the constitution of qi deficiency and fatigue and qi deficiency with edema. Yam extract powder can invigorate the spleen and stomach, promote the production of body fluid and moisten the lungs. The two work together to tonify qi and lift yang and promote the movement of water and dampness. Among them, coix seed extract powder and poria cocos extract powder are used as the "minister drugs". Coix seed extract powder can strengthen the spleen and promote diuresis and percolate dampness. Poria cocos extract powder can promote diuresis and resolve edema, strengthen the spleen and promote digestion for the constitution of edema with scanty urination, spleen deficiency with less appetite, and loose stools. Among them, amomum villosum extract powder is used as the "assistant drug" and can promote the circulation of qi and resolve dampness. Among them, tangerine peel extract powder is used as the "courier drug" and can regulate qi and strengthen the spleen, dry dampness and resolve phlegm.

[0024] In some embodiments, the mass ratio of the spraying granule and the nano-SiO 2 -magnesium stearate double-layer coated powder is (0.4 - 0.6):1.

[0025] Preferably, the mass ratio of the spraying granule and the nano-SiO 2 -magnesium stearate double-layer coated powder is 0.48:1.

[0026] More preferably, the mass ratio of the spraying granule and the nano-SiO 2 -magnesium stearate double-layer coated powder is 0.5:1.

[0027] Regarding the spraying granule:

[0028] The oligosaccharide solution is a solution obtained by dissolving oligosaccharides in purified water. In some embodiments, 20 - 30 parts of xylooligosaccharides are weighed and dissolved in 160 - 200 parts of purified water solution, and the temperature is adjusted to 38 - 42 °C to obtain the oligosaccharide solution.

[0029] Preferably, 28 parts of xylooligosaccharides are weighed and dissolved in 180 parts of purified water solution, and the temperature is adjusted to 40 °C to obtain the oligosaccharide solution.

[0030] The premixed powder includes 500 - 1000 parts by mass of cranberry fruit powder, 10 - 60 parts by mass of coix seed extract powder, 10 - 60 parts by mass of poria cocos extract powder, 0.5 - 10 parts by mass of astragalus membranaceus extract powder, 0.5 - 10 parts by mass of tangerine peel extract powder, 10 - 60 parts by mass of Chinese yam extract powder, 0.5 - 10 parts by mass of amomum villosum extract powder, 100 - 340 parts by mass of white kidney bean extract, and 10 - 40 parts by mass of EGCG.

[0031] Preferably, the premixed powder includes 611 parts by mass of cranberry fruit powder, 51 parts by mass of coix seed extract powder, 51 parts by mass of poria cocos extract powder, 5 parts by mass of astragalus membranaceus extract powder, 5 parts by mass of tangerine peel extract powder, 51 parts by mass of Chinese yam extract powder, 5 parts by mass of amomum villosum extract powder, 324 parts by mass of white kidney bean extract, and 32 parts by mass of EGCG.

[0032] In some embodiments, the premixed powder is placed in a granulating device and the oligosaccharide solution is sprayed onto the premixed powder at a certain spraying speed to obtain spray granulates; in other embodiments, the premixed powder and the oligosaccharide solution are mixed and then transported to a spray drying device to prepare spray granulates.

[0033] Regarding nano - SiO 2 - magnesium stearate double - coated powder:

[0034] The xylo - oligosaccharide - xylitol co - crystalline powder is obtained by gradient cooling and drying co - crystallization with a ratio of xylo - oligosaccharide to xylitol of 1:3. The xylo - oligosaccharide - xylitol co - crystalline powder of this solution forms a hydrophobic surface to block moisture absorption at the molecular level.

[0035] It should be noted that the xylo - oligosaccharide and xylitol of this solution form a xylo - oligosaccharide - xylitol co - crystalline powder through co - crystallization technology. During the co - crystallization process of xylo - oligosaccharide and xylitol, the short chain of xylo - oligosaccharide covers the hydroxyl group (-OH) of xylitol, reducing the surface polarity through hydrogen bond recombination. The reduction of free hydroxyl groups in the xylitol molecule and the wrapping of the short chain of xylo - oligosaccharide form a dense hydrophobic layer on the crystal surface, making it difficult for water molecules to adsorb.

[0036] In addition, the nano - SiO 2 - magnesium stearate double - coated powder includes, from the outside to the inside, a wrapping outer layer composed of magnesium stearate, a wrapping inner layer composed of nano - SiO 2 and a xylo - oligosaccharide - xylitol co - crystalline powder. In other words, the xylo - oligosaccharide - xylitol co - crystalline powder is wrapped by nano - SiO 2 for the inner layer and by magnesium stearate for the outer layer. Through nano - SiO 2-The double-layer coating of magnesium stearate achieves multi-dimensional anti-caking and significantly improves the anti-hygroscopicity ability of the powder.

[0037] Nano-SiO 2 -Magnesium stearate double-layer coated powder composed of nano-SiO 2 The inner layer of the package is filled with particle gaps by physical adsorption to form a nano-scale isolation layer to block the water molecule penetration path, while the outer layer of the package composed of magnesium stearate acts as a lubricant covering the nano-SiO 2 The outer layer of the nano-SiO 2 -Nano-SiO in double-layer coated magnesium stearate powder 2 It plays the role of physical shielding, and magnesium stearate plays the role of chemical hydrophobicity, achieving the dual protection of "hydrophobic + isolation".

[0038] In some embodiments, nano-SiO 2 -The magnesium stearate double-layer coated powder contains 20 to 40 parts by weight of nano-SiO 2 , 20 to 40 parts by weight of magnesium stearate, 1000 to 2000 parts by weight of xylitol and 300 to 1100 parts by weight of xylo-oligosaccharides, wherein the ratio of xylo-oligosaccharides to xylitol is 1:3.

[0039] Preferably, nano-SiO 2 -Magnesium stearate double-layer coated powder contains 35 parts by mass of nano-SiO 2 , 35 parts by mass of magnesium stearate, 1622 parts by mass of xylitol and 540 parts by mass of xylo-oligosaccharides.

[0040] In order to more clearly demonstrate the mass ratio of each component in the Chinese and Western composite powder that helps to remove dampness and reduce fat of this solution, the mass ratio of the components in the Chinese and Western composite powder that helps to remove dampness and reduce fat of a specific embodiment is now shown in the form of the following Table 1:

[0041] Table 1. Components by weight of Chinese and Western compound powder that helps to remove dampness and reduce fat

[0042]

[0043]

[0044] On the other hand, the present invention provides a method for preparing a Chinese and Western composite powder that helps to remove dampness and reduce fat, comprising the following steps:

[0045] S1: Preparation of spray particles:

[0046] Mix cranberry fruit powder, coix seed extract powder, poria cocos extract powder, astragalus membranaceus extract powder, citrus reticulata extract powder, Chinese yam extract powder, amomum villosum extract powder, white kidney bean extract and EGCG to obtain a premix powder;

[0047] Dissolve oligosaccharide in purified water to obtain an oligosaccharide solution;

[0048] Use the oligosaccharide solution to granulate the premix powder to obtain spray granulates;

[0049] S2: Prepare nano-SiO 2 - magnesium stearate double-coated powder:

[0050] Dissolve xylitol in an ethanol-aqueous solution, then add xylo-oligosaccharide to obtain a mixed solution, and perform gradient cooling crystallization and dry co-crystallization treatment on the mixed solution to obtain xylo-oligosaccharide-xylitol co-crystallized powder;

[0051] Place the xylo-oligosaccharide-xylitol co-crystallized powder in a fluidized bed and spray the nano-SiO 2 dispersion liquid to obtain SiO 2 coated powder, and use a magnesium stearate suspension to spray the SiO 2 coated powder and then dry to obtain nano-SiO 2 - magnesium stearate double-coated powder;

[0052] S3: Prepare a Chinese and Western compound powder:

[0053] Mix Bifidobacterium breve B-3, vitamin B, spray granulates and nano-SiO 2 - magnesium stearate double-coated powder to obtain a Chinese and Western compound powder.

[0054] In addition, when the Chinese and Western compound powder that helps to dispel dampness and reduce fat contains fruit powder for regulating taste, add coix seed extract powder, poria cocos extract powder, astragalus membranaceus extract powder, citrus reticulata extract powder, Chinese yam extract powder, amomum villosum extract powder, white kidney bean extract and EGCG to the fruit powder and mix to obtain a premix powder.

[0055] It should be noted that the proportional relationship of each component involved in the preparation method of the Chinese and Western compound powder that helps to dispel dampness and reduce fat is the same as the implementation content of the Chinese and Western compound powder that helps to dispel dampness and reduce fat introduced above, and no redundant description will be given here. The following will focus on the specific process steps.

[0056] In the step of preparing spray granulates in step S1,

[0057] Weigh xylo-oligosaccharide with purified aqueous solution, and adjust the temperature to 38-42 °C to obtain an oligosaccharide solution. Preferably, adjust the temperature to 40 °C to obtain an oligosaccharide solution.

[0058] Moreover, in this solution, an oligosaccharide solution is used as the spraying slurry to granulate the premix powder conventionally to obtain spraying granules.

[0059] In a specific embodiment, the prepared premix powder is placed in a professional granulating device and the stirring device is turned on. The premix powder is stirred at a low speed to be preliminarily mixed evenly to form a loose powder state. The prepared oligosaccharide solution is transported to the nozzle installed at the top of the granulating device through a peristaltic pump and sprayed on the premix powder in a uniform and fine mist. As the oligosaccharide solution is continuously sprayed, the premix powder gradually absorbs the water in the solution and begins to agglomerate. Under the action of the stirring paddle, these agglomerated powders keep tumbling and colliding, and further fuse into spraying granules with relatively uniform sizes.

[0060] In step S2 for preparing the nano-SiO 2 -magnesium stearate double-coated powder step:

[0061] In some embodiments, at 48 - 52 °C, xylitol is dissolved in a 70% ethanol - aqueous solution and stirred until completely dissolved. Subsequently, xylooligosaccharide is added and the temperature is maintained at 48 - 52 °C, and the stirring speed is increased to obtain a uniformly dispersed mixture.

[0062] Preferably, the temperature for preparing the mixture is always controlled at 50 °C.

[0063] In some embodiments, the gradient cooling crystallization of the mixture further includes the steps of: cooling the mixture to 30 °C at 0.5 °C / min and continuously stirring, and then cooling the mixture to 15 °C at 0.2 °C / min. When the turbidity of the mixture reaches 80 NTU, the cooling is stopped.

[0064] It should be noted that in this solution, the mixture is subjected to gradient cooling crystallization. In the first stage, the mixture is cooled to 30 °C at 0.5 °C / min and continuously stirred at a speed of 500 rpm. The purpose of this stage is to induce the formation of crystal nuclei. An appropriate cooling rate and stirring can promote the oligosaccharide and xylitol molecules in the solution to start orderly aggregation, forming a suitable number and uniformly distributed crystal nuclei. If the cooling rate is too fast, crystal nuclei may form in large quantities in a short time, resulting in too many crystal nuclei with different sizes, ultimately affecting the quality and structure of the crystals. And if the stirring speed is inappropriate, it will also cause uneven distribution of crystal nuclei, which is not conducive to the subsequent crystal growth. In the second stage, the mixture is cooled to 15 °C at 0.2 °C / min. The purpose of this stage is to promote the directional growth of crystals. In this stage, the slow cooling rate provides sufficient time for crystal growth, enabling the crystal nuclei to grow orderly according to a certain lattice structure and gradually form regular crystal shapes. If this stage is skipped or the cooling rate is unreasonable, the crystals may grow disorderly and cannot form a tight and uniform co-crystalline structure, affecting its hydrophobic performance and overall performance.

[0065] In some embodiments, the steps of gradient cooling crystallization of the mixed solution followed by drying co-crystallization include: obtaining a filter cake by vacuum filtration, washing the filter cake with low-temperature ethanol, and then drying it on a fluidized bed to obtain nano-SiO 2 -magnesium stearate double-layer coated powder.

[0066] Specifically, the vacuum pressure for vacuum filtration is -0.08 Mpa, the temperature of the low-temperature ethanol is 4°C, and the filter cake is washed 3 times with the low-temperature ethanol. The conditions for fluidized bed drying are an inlet air temperature of 40°C, a wind speed of 1.5 m / s, and a time of 2 h.

[0067] In some embodiments, nano-SiO 2 is dispersed in water to obtain a nano-SiO 2 dispersion.

[0068] Specifically, high-speed shearing and ultrasonic treatment are used to disperse nano-SiO 2 in water to obtain a nano-SiO 2 dispersion. In some embodiments, the high-speed shearing speed is 9000 - 11000 rpm for 8 - 12 min. Preferably, the high-speed shearing speed is 10000 rpm for 10 min. In some embodiments, the ultrasonic treatment power is 250 - 350 W, the frequency is 18 - 22 kHz, and the treatment time is 10 - 20 min. Preferably, the ultrasonic treatment power is 300 W, the frequency is 20 kHz, and the treatment time is 15 min.

[0069] In addition, the xylooligosaccharide-xylitol co-crystalline powder is preheated on a fluidized bed to 30 - 40°C, sprayed with the nano-SiO 2 dispersion, and then dried to obtain SiO 2 coated powder, where the drying conditions are treatment at 40°C - 45°C for 15 - 25 min.

[0070] Preferably, the xylooligosaccharide-xylitol co-crystalline powder is preheated on a fluidized bed to 35°C, sprayed with the nano-SiO 2 dispersion, and then dried at 40°C for 15 min to obtain SiO 2 coated powder.

[0071] In some embodiments, magnesium stearate is dispersed in absolute ethanol to obtain a magnesium stearate suspension, where the magnesium stearate suspension has no visible particles to the naked eye.

[0072] Specifically, magnesium stearate was dispersed in absolute ethanol by magnetic stirring to obtain a magnesium stearate suspension. In some embodiments, the speed of magnetic stirring is 400-600 rpm, and the stirring time is 25-35 min. Preferably, the speed of magnetic stirring is 500 rpm and the stirring time is 30 min.

[0073] In addition, the SiO 2 coated powder was preheated to 40-45 °C, and the magnesium stearate suspension was sprayed and then dried to obtain nano-SiO 2 -magnesium stearate double-layer coated powder, wherein the drying conditions are treatment at 45 °C to 50 °C for 15 min to 25 min.

[0074] Preferably, the SiO 2 coated powder was preheated to 40 °C, the magnesium stearate suspension was sprayed, and then dried at 45 °C for 15 min to obtain nano-SiO 2 -magnesium stearate double-layer coated powder.

[0075] Compared with the prior art, the technical solution has the following characteristics and beneficial effects:

[0076] The Chinese and Western compound powder provided by this solution, which helps to dispel dampness and reduce fat, can reconcile the constitutions of obese people with qi deficiency, phlegm-dampness or comprehensive constitutions to enhance the whole-body metabolic power. Among them, Bifidobacterium breve B-3 and white kidney bean extract synergistically block carbohydrates, EGCG and vitamin B synergistically inhibit fat synthesis, and Bifidobacterium breve B-3 decomposes fat to reduce fat accumulation. The four substances act on different targets to directly intervene in metabolism, and can achieve the effect of weight loss and fat reduction in a short period. The Chinese medicine combination starts from the mechanism of tonifying qi-promoting qi-removing dampness, improves the constitutions of obese people with qi deficiency, phlegm-dampness or comprehensive constitutions, and solves the problem that the body's metabolic function is affected by dampness from the source, resulting in reduced energy consumption and easy fat accumulation. The Chinese and Western components cooperate with each other, can effectively dispel dampness, reduce weight and fat without exercise and energy control, and at the same time solve the problem of easy rebound after weight loss.

[0077] Moreover, in the specific preparation process of the Chinese and Western compound powder provided by this solution, xylooligosaccharide and xylitol form a hydrophobic surface through gradient cooling and drying co-crystallization in a ratio of 1:3 to block moisture absorption at the molecular level, and are double-layer coated with nano-SiO 2 -magnesium stearate, with multi-dimensional anti-caking, significantly improving the moisture absorption resistance of the powder. Compared with the microencapsulation method, it directly uses the interaction between components to form a structure and reduces excipients, and due to the synergistic effect, the dosage of magnesium stearate and SiO 2 can be reduced. Description of the Drawings

[0078] Figure 1 is a specific product diagram of the Chinese and Western compound powder prepared in Example 1 of this solution, which helps to dispel dampness and reduce fat.

[0079] Figure 2 It is a comparison diagram of caking conditions when Example 1 and Comparative Examples 1 to 5 are accelerated and placed for 7 days. Detailed implementation manners

[0080] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art belong to the scope of protection of the present invention.

[0081] I. Design of examples and comparative examples:

[0082] Example 1:

[0083] S1: Prepare spray granulates:

[0084] ① Premixed powder: 611 parts of cranberry fruit powder are crushed and sieved, and 51 parts of coix seed extract powder, 51 parts of poria cocos seed extract powder, 5 parts of astragalus extract powder, 5 parts of tangerine peel extract powder, 51 parts of yam extract powder, 5 parts of amomum villosum extract powder, 324 parts of white kidney bean extract, and 32 parts of EGCG (epigallocatechin gallate) are added to obtain a premixed powder for standby;

[0085] ② Oligosaccharide solution: Weigh 28 parts of xylooligosaccharide, dissolve it in 180 parts of purified water, and adjust the temperature to 40 °C to obtain an oligosaccharide solution;

[0086] ③ Granulation: Granulate the premixed powder 1 with the oligosaccharide solution to obtain spray granulates.

[0087] S2: Prepare nano-SiO 2 - Magnesium stearate double-layer coated powder:

[0088] At 50 °C, add 1622 parts of xylitol to 1200 parts of 70% ethanol-aqueous solution and stir until completely dissolved to ensure that the xylitol is fully dissolved. Subsequently, add 540 parts of xylooligosaccharide and maintain the temperature at 50 °C, and increase the stirring speed to 500 rpm to form a uniform mixture. Cool the uniform mixture to 30 °C at a rate of 0.5 °C / min and continue to stir at 500 rpm. Then continue to cool the uniform mixture to 15 °C at a rate of 0.2 °C / min. Stop cooling when the turbidity of the solution reaches 80 NTU monitored by an online turbidimeter. Subsequently, perform vacuum filtration under a pressure of -0.08 Mpa to obtain a filter cake. Wash the filter cake 3 times with ethanol at 4 °C to remove residual moisture, and then use fluidized bed drying (inlet air temperature 40 °C, wind speed 1.5 m / s, time 2 h) to obtain a co-crystalline powder.

[0089] Add 35 parts of SiO2 Dispersed in 3500 parts of water, and the dispersion method is high-speed shearing (10,000 rpm, 10 min) and ultrasonic treatment (power 300 W, frequency 20 kHz, 15 min). Place 2162 parts of the co-crystallized powder in a fluidized bed and preheat it to 35 °C, then spray the nano-SiO 2 dispersion liquid, dry after coating (40 °C, 20 min), with a coating weight gain of 0.5%, to obtain SiO 2 coated powder.

[0090] Disperse 35 parts of magnesium stearate in 1750 parts of absolute ethanol, and use magnetic stirring (500 rpm, 30 min) until a stable suspension (no visible particles to the naked eye) is formed. Preheat the SiO 2 coated powder to 40 °C and then spray the magnesium stearate suspension, dry (45 °C, 15 min) until the coating weight gain is 0.3% to form an outer hydrophobic film, to obtain nano-SiO 2 -magnesium stearate double-layer coated powder.

[0091] S3: Prepare the traditional Chinese and Western compound powder:

[0092] Weigh 114 parts of Bifidobacterium breve B-3, 4 parts of vitamin B complex premix, spray granule and nano-SiO 2 -magnesium stearate double-layer coated powder and mix evenly to obtain the total mixture, and divide it into portions of 1.3 g / bottle.

[0093] Comparative example 1:

[0094] The main difference compared with Example 1 is that the co-crystallization and coating preparation of nano-SiO 2 -magnesium stearate double-layer coated powder were not carried out, but xylo-oligosaccharide, xylitol, silicon dioxide, and magnesium stearate were directly mixed.

[0095] Specifically, step S2 is: directly mix 1622 parts of xylitol, 540 parts of xylo-oligosaccharide, 35 parts of SiO 2 and 35 parts of magnesium stearate to obtain mixed particles; subsequently, in step S3, use the mixed particles to replace nano-SiO 2 -magnesium stearate double-layer coated powder.

[0096] Comparative example 2:

[0097] The main difference compared with Example 1 is that the double-layer coating of nano-SiO 2 and magnesium stearate was not carried out, but SiO 2 and magnesium stearate were directly mixed.

[0098] Specifically, step S2 is:

[0099] At 50 °C, 1622 parts of xylitol were added to 1200 parts of 70% ethanol-aqueous solution and stirred until completely dissolved to ensure that the xylitol was fully dissolved. Subsequently, 540 parts of xylo-oligosaccharide were added and the temperature was maintained at 50 °C, and the stirring speed was increased to 500 rpm to form a homogeneous mixture. The homogeneous mixture was cooled to 30 °C at a rate of 0.5 °C / min and continuously stirred under the stirring condition of 500 rpm. Then, it was further cooled to 15 °C at a rate of 0.2 °C / min. The cooling was stopped when the turbidity of the solution reached 80 NTU monitored by an on-line turbidimeter. Subsequently, vacuum filtration was carried out under a pressure of -0.08 Mpa to obtain a filter cake. The filter cake was washed 3 times with ethanol at 4 °C to remove residual moisture, and then fluidized bed drying was carried out (inlet air temperature 40 °C, wind speed 1.5 m / s, time 2 h) to obtain a co-crystallized powder;

[0100] The co-crystallized powder and 35 parts of SiO 2 and 35 parts of magnesium stearate were directly mixed to obtain mixed granules; subsequently, in step S3, the mixed granules were used instead of nano-SiO 2 -magnesium stearate double-coated powder.

[0101] Comparative Example 3:

[0102] The main difference compared with Example 1 was that the ratio of xylo-oligosaccharide to xylitol was 0.5:3 during the preparation of nano-SiO 2 -magnesium stearate double-coated powder, that is, 308 parts of xylo-oligosaccharide and 1854 parts of xylitol.

[0103] Comparative Example 4: The main difference compared with Example 1 was that the ratio of xylo-oligosaccharide to xylitol was 3:3 during the preparation of nano-SiO 2 -magnesium stearate double-coated powder, that is, 1081 parts of xylo-oligosaccharide and 1081 parts of xylitol.

[0104] Comparative Example 5:

[0105] The main difference compared with Example 1 was that in the first stage of gradient cooling crystallization for preparing the co-crystallized powder, the temperature was cooled to 30 °C at a rate of 1 °C / min.

[0106] Comparative Example 6:

[0107] The main difference compared with Example 1 was that no extract powder was added to the formula.

[0108] Specifically, step S1 was as follows:

[0109] ① Premixed powder: 611 parts of cranberry fruit powder was crushed and sieved, and 324 parts of white kidney bean extract and 32 parts of EGCG (epigallocatechin gallate) were added to obtain a premixed powder for standby;

[0110] ② Oligosaccharide solution: Weigh 28 parts of xylo-oligosaccharide, dissolve it in 180 parts of purified water, and adjust the temperature to 40 °C to obtain the oligosaccharide solution.

[0111] ③ Granulation: Granulate the premix powder 1 with the oligosaccharide solution to obtain spray granulated particles.

[0112] Step S2 is the same as step S3.

[0113] Comparative Example 7:

[0114] The main difference compared with Example 1 is that the formula does not add white kidney bean extract, EGCG, Bifidobacterium B-3, and B vitamins.

[0115] Specifically, step S1 is:

[0116] ① Premix powder: Grind and sieve 611 parts of cranberry fruit powder, add 51 parts of coix seed extract powder, 51 parts of poria cocos seed extract powder, 5 parts of astragalus root extract powder, 5 parts of tangerine peel extract powder, 51 parts of Chinese yam extract powder, and 5 parts of amomum fruit extract powder to obtain the premix powder for standby;

[0117] ② Oligosaccharide solution: Weigh 28 parts of xylo-oligosaccharide, dissolve it in 180 parts of purified water, and adjust the temperature to 40 °C to obtain the oligosaccharide solution.

[0118] Granulation: Granulate the premix powder 1 with the oligosaccharide solution to obtain spray granulated particles.

[0119] Step S3 is:

[0120] Weigh the spray granulated particles and the nano-SiO 2 -magnesium stearate double-coated powder and mix evenly to obtain the total mixture, and pack it in 1.3 g / bottles.

[0121] Step S2 is the same.

[0122] Comparative Example 8:

[0123] The main difference compared with Example 1 is that the formula does not add white kidney bean extract, EGCG, Bifidobacterium B-3, B vitamins, astragalus root extract powder, and amomum fruit extract powder.

[0124] Specifically, step S1 is:

[0125] ① Premix powder: Grind and sieve 611 parts of cranberry fruit powder, add 51 parts of coix seed extract powder, 51 parts of poria cocos seed extract powder, 5 parts of tangerine peel extract powder, 51 parts of Chinese yam extract powder to obtain the premix powder for standby;

[0126] ② Oligosaccharide solution: Weigh 28 parts of xylo-oligosaccharide, dissolve it in 180 parts of purified water, and adjust the temperature to 40 °C to obtain the oligosaccharide solution.

[0127] Granulation: The premixed powder 1 is granulated with an oligosaccharide solution to obtain spray granulated particles.

[0128] Step S3 is as follows:

[0129] Weigh the spray granulated particles and the nano-SiO 2 - magnesium stearate double-layer coated powder and mix evenly to obtain the total mixture, which is then sub-packed at 1.3 g / bottle.

[0130] It is the same as step S2.

[0131] II. Process step verification:

[0132] Experimental design:

[0133] Grouping: Two groups are set for each of Example 1 and Comparative Examples 1-5. One group is used to investigate the moisture absorption rate, and the other group is used to investigate the caking rate. Three parallel samples are placed in each group, and each sample is 1.3 g. Before testing, each group is placed in a thermostatic and humidistatic chamber and balanced for 24 h.

[0134] Placement conditions: Exposed to an environment of 40°C / 75% RH.

[0135] Index detection method:

[0136] Moisture absorption test: After the sample is taken out at the test time point, weigh the weight change before and after moisture absorption with an analytical balance; calculate the moisture absorption rate: Moisture absorption rate = (Wt - W0) / W0 × 100% (W0: initial weight, Wt: weight after time t). All weighing operations are carried out in a drying oven with a humidity < 30% RH.

[0137] Caking rate test: After the sample is taken out at the test time point, the sample after the accelerated test is passed through a 20-mesh sieve (aperture 850 μm), and the weight of the caked mass that does not pass through the sieve is weighed. Caking rate = Wcaking / Wtotal × 100%.

[0138] The test results of Example 1 and Comparative Examples 1-5 are shown in Table 2 below:

[0139] Table 2 Test result table of Example 1 and Comparative Examples 1-5

[0140]

[0141] Result description: Judging from the data trend of each group, the moisture absorption rate is proportional to the caking rate. Among them, Comparative Example 1, which is simply mixed without any treatment, has the most serious moisture absorption and caking. Example 1 has the best short-term and long-term moisture / caking resistance under accelerated conditions. Comparative Example 2 without double-layer coating is the second best, indicating that co-crystallization of fructooligosaccharide and xylitol can greatly improve the moisture absorption and caking phenomenon. Comparing with the results of Example 1, it shows that co-crystallization and nano-SiO 2-The double-layer coating of magnesium stearate has a synergistic effect. In the preparation of co-crystallized powder, the proportion of xylo-oligosaccharides was reduced and increased respectively in Comparative Examples 3 and 4, and the effect was significantly lower than that in Example 1 and Comparative Example 2. The reason may be that the amount of xylo-oligosaccharides is low and the short chain coverage is insufficient, resulting in a loose crystal structure; if the amount of xylo-oligosaccharides is too high, the molecules cannot be orderly embedded in the crystal lattice of xylitol, resulting in an increase in dislocation density and free xylo-oligosaccharides easily becoming new hygroscopic sites, indicating the importance of the ratio of the two. In the preparation of co-crystallized powder, the first stage of gradient cooling crystallization in Comparative Example 5 was cooled at a faster rate, and the effect was also significantly lower than that in Example 1. It may be that too fast will lead to an increase in crystal defects, indicating the importance of the gradient cooling rate.

[0142] 3. Formula Verification:

[0143] Volunteer inclusion criteria:

[0144] Age 25-50 years, BMI ≥ 24 kg / m 2 (overweight / obesity);

[0145] In line with TCM phlegm-dampness constitution: judged according to the "TCM Constitution and Classification Standards". If the conversion score of partial constitution is between 40 and 100 points, it is judged as conformity, and if the conversion score of partial constitution is between 30 and 39 points, it is judged as tendency to be.

[0146] I have not taken any diet pills or Chinese medicine for the past 3 months.

[0147] Exclusion criteria:

[0148] People with severe heart, liver and kidney diseases, pregnant women, and those who are allergic to Chinese medicine.

[0149] Experimental Design:

[0150] Grouping: Example 1 and Comparative Examples 6-8: 10 women each, once a day, 2 bottles each time, 7-9 am, pour into the mouth before meals. The placebo group took ordinary fruit powder:

[0151] All subjects maintained their original diet and exercise habits and only recorded daily diet logs (to avoid deliberate dieting to interfere with the results). The trial period was 14 weeks (taking the drug for 12 weeks and following up after stopping the drug for 2 weeks).

[0152] Monitoring indicators: body weight (kg), BMI, waist-to-hip ratio, body fat percentage, 6-minute walk test (6MWT) to record walking distance to assess physical strength improvement and physical fitness identification.

[0153] Judging criteria:

[0154] ① Significant effect: weight loss of more than 5kg, BMI decreased by 2kg / m 2 ②Effective: weight loss 3-5kg, BMI reduction 1-2kg / m2 ; ③ Ineffective: Weight loss is less than 3 kg, and BMI decreases by less than 1 kg / m 2 or less.

[0155] The test result tables of Example 1 and Comparative Examples 6 - 8 are shown in Table 3 below:

[0156] Table 3 Test Result Tables of Example 1 and Comparative Examples 6 - 8

[0157]

[0158] Judging from the test data at 12 weeks:

[0159] Fat loss and weight loss efficiency: Example 1 is the best in improving several indicators such as weight, waist - hip ratio, body fat, physical strength, and physical constitution. It proves that there is a synergistic effect among the components of the damp - eliminating and fat - reducing composition. It can be seen from Comparative Example 6 and Comparative Example 7 that the western components have better short - term effects on fat loss and weight loss than the pure Chinese - style combination. In terms of physical constitution improvement: Comparative Example 6 has no effect on physical constitution. It can be seen from Comparative Example 7 and Comparative Example 8 that the formula with the addition of the Chinese medicine components astragalus root and fructus amomi extract powder is better than the group without addition. Maybe because astragalus root supplements qi, and qi can promote the metabolism of body fluids, so it enhances the effect of supplementing qi and strengthening the spleen, thus strengthening the effect of eliminating dampness. Fructus amomi can promote qi circulation to eliminate dampness, warm the middle - jiao, and may help the spleen and stomach in transportation and transformation, reducing the generation of dampness. It can be seen from Comparative Example 7 and Comparative Example 8 that the 6MWT walking distance in Comparative Example 7 increased by 110 m while that in Comparative Example 8 decreased by 70 m. The conversion score of phlegm - damp constitution in Comparative Example 7 is significantly lower than that in Comparative Example 8, and at the same time, the conversion score of qi - deficiency constitution is reduced; after taking Comparative Example 8, although the conversion score of phlegm - damp constitution decreased, the conversion score of qi - deficiency constitution increased, and the physical constitution of the test population changed to a tendency of complex qi - deficiency and phlegm - damp constitution. Comparative Example 7 plays a role in supplementing qi during the process of eliminating dampness, while the formula of Comparative Example 8 is aimed at eliminating dampness alone, which may damage the spleen qi. Without qi - supplementing herbs, long - term use may lead to a decrease in qi - deficiency and physical strength.

[0160] Judging from the follow - up test data:

[0161] Except for Example 1 and Comparative Example 7, which simultaneously added Astragalus, Chinese yam, Poria, Coix seeds, Amomum, and dried orange peel extract powder, the weight and various indicators of other effective test groups all rebounded to varying degrees, among which the rebound of Comparative Example 6, a Western-style prescription without any Chinese medicine prescription, was the most obvious (recovered 2.5kg), significantly higher than Example 1 (recovered 0.3kg). It can be seen from Comparative Example 6 and Example 1 that the prescription has no Chinese medicine ingredients, and it is difficult to regulate the root causes of obesity (such as spleen deficiency, damp-heat constitution), "treating the symptoms but not the root cause". For example, simply relying on the inhibition of α-amylase may inhibit carbon water absorption, but if the spleen and stomach transportation function is poor, unabsorbed carbohydrates are easily fermented and gasified, which aggravates abdominal distension instead; and the prescription is often time-sensitive, and the effect decreases if it is not continued to be taken. The reason for the rebound of Comparative Example 8 may be because its prescription dehumidification does not consolidate the foundation, and simple dehumidification is difficult to cure, and qi deficiency leads to water and moisture transportation and transformation weakness, short-term drainage and weight loss but easy rebound. In summary, the synergistic clinical effect of the full formula combination is better than any incomplete combination, achieving multiple synergies of "removing dampness" and "reducing weight and fat". It has a wider adaptability and can be suitable for people with phlegm-dampness type, qi deficiency type or comprehensive constitution, and better meets the public's demand for products for removing dampness and reducing fat.

[0162] Those skilled in the art should understand that the technical features of the above embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0163] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A Chinese and Western composite powder that helps to remove dampness and reduce fat, characterized in that: include: Bifidobacterium breve B-3, vitamin B, spray particles and nano-SiO2-magnesium stearate double-layer coated powder; wherein the spray particles are obtained by spraying premixed powder with oligosaccharide solution, wherein the premixed powder includes mixed cranberry fruit powder, coix seed extract powder, tuckahoe extract powder, astragalus extract powder, tangerine peel extract powder, yam extract powder, amomum extract powder, white kidney bean extract and EGCG; The nano-SiO2-magnesium stearate double-layer coated powder is a xylooligosaccharide-xylitol co-crystallized powder double-layered by nano-SiO2 and magnesium stearate.

2. The Chinese and Western composite powder for removing dampness and reducing fat according to claim 1, characterized in that: The premixed powder includes 500-1000 parts by weight of cranberry fruit powder, 10-60 parts by weight of coix seed extract powder, 10-60 parts by weight of poria extract powder, 0.5-10 parts by weight of astragalus extract powder, 0.5-10 parts by weight of tangerine peel extract powder, 10-60 parts by weight of yam extract powder, 0.5-10 parts by weight of amomum villosum extract powder, 200-340 parts by weight of white kidney bean extract and 10-40 parts by weight of EGCG.

3. The Chinese and Western composite powder for removing dampness and reducing fat according to claim 1, characterized in that: The mass ratio of the sprayed particles and the nano-SiO2-magnesium stearate double-layer coated powder is (0.4-0.6):

1.

4. The Chinese and Western composite powder for removing dampness and reducing fat according to claim 1, characterized in that: The xylooligosaccharide-xylitol co-crystallized powder is obtained by gradient cooling and drying co-crystallization with a ratio of xylooligosaccharide to xylitol of 1:

3.

5. The Chinese and Western composite powder for removing dampness and reducing fat according to claim 1, characterized in that: The nano-SiO2-magnesium stearate double-layer coated powder comprises an outer coating layer composed of magnesium stearate, an inner coating layer composed of nano-SiO2 and xylo-oligosaccharide-xylitol co-crystallized powder.

6. The Chinese and Western composite powder for removing dampness and reducing fat according to claim 1, characterized in that: The nano-SiO2-magnesium stearate double-layer coated powder contains 20-40 parts by weight of nano-SiO2, 20-40 parts by weight of magnesium stearate, 1000-2000 parts by weight of xylitol and 300-1100 parts by weight of xylo-oligosaccharide.

7. A method for preparing a Chinese and Western composite powder that helps to remove dampness and reduce fat, characterized in that: Includes steps: S1: Preparation of spray particles: Mix cranberry fruit powder, coix seed extract powder, tuckahoe extract powder, astragalus extract powder, tangerine peel extract powder, yam extract powder, amomum villosum extract powder, white kidney bean extract and EGCG to obtain a premixed powder; dissolving oligosaccharides in purified water to obtain an oligosaccharide solution; The premixed powder is granulated with an oligosaccharide solution to obtain spray granules; S2: Preparation of nano-SiO2-magnesium stearate double-layer coated powder: Dissolving xylitol in an ethanol-water solution and then adding xylo-oligosaccharide to obtain a mixed solution, subjecting the mixed solution to gradient cooling crystallization and drying co-crystallization treatment to obtain xylo-oligosaccharide-xylitol co-crystallization powder; The xylooligosaccharide-xylitol co-crystallized powder is placed in a fluidized bed and sprayed with a nano-SiO2 dispersion to obtain a SiO2 coated powder, and the SiO2 coated powder is sprayed with a magnesium stearate suspension and then dried to obtain a nano-SiO2-magnesium stearate double-layer coated powder; S3: Preparation of Chinese and Western composite powder: The Chinese and Western composite powder is obtained by mixing Bifidobacterium breve B-3, vitamin B, spray particles and nano-SiO2-magnesium stearate double-layer coated powder.

8. The method for preparing the Chinese and Western composite powder that helps to remove dampness and reduce fat according to claim 7, characterized in that: The gradient cooling crystallization of the mixed solution further includes the steps of cooling the mixed solution to 30°C at 0.5°C / min and continuously stirring, then cooling the mixed solution to 15°C at 0.2°C / min, and stopping the cooling when the turbidity of the mixed solution reaches 80NTU.

9. The method for preparing the Chinese and Western composite powder that helps to remove dampness and reduce fat according to claim 7, characterized in that: Nano-SiO2 is dispersed in water by high-speed shearing and ultrasonic treatment to obtain nano-SiO2 dispersion, and oligoxylose-xylitol co-crystallized powder is placed on a fluidized bed and preheated to 30-40°C, sprayed with the nano-SiO2 dispersion and then dried to obtain SiO2 coated powder, wherein the drying condition is to treat at 40°C-45°C for 15-25 minutes.

10. The method for preparing the Chinese and Western composite powder that helps to remove dampness and reduce fat according to claim 7, characterized in that: Magnesium stearate is dispersed in anhydrous ethanol to obtain a magnesium stearate suspension, wherein the magnesium stearate suspension has no particles visible to the naked eye, SiO2 coated powder is preheated to 40-45°C, sprayed with the magnesium stearate suspension, and then dried to obtain nano SiO2-magnesium stearate double-layer coated powder, wherein the drying condition is to treat at 45°C-50°C for 15min-25min.

Images