Laser ablation catheter guided by optical imaging

Abstract

The invention discloses an optical imaging guided laser ablation catheter which comprises a laser ablation outer catheter, an OCT catheter, a probe connecting inner tube and a laser ablation catheter tail handle, a head end developing mark is arranged in the laser ablation outer catheter along the head of the far end, and two positioning marks are arranged on the inner side close to the head end developing mark. The head end developing mark is made of an annular developing material, the positioning mark is made of a circular-arc-shaped developing material, and the head end developing mark and the positioning mark are matched to display the head end rotation angle of the laser ablation outer catheter; the laser ablation outer catheter is also provided with a first conductive induction contact; the OCT catheter is inserted into the laser ablation outer catheter in a penetrating mode, and the OCT catheter is provided with an induction piece; and the probe connecting inner tube is provided with a second conductive induction contact. The closed-loop angle positioning imaging laser ablation catheter can tightly combine a laser ablation position and an OCT image and is used for carotid plaque ablation, so that operation wounds caused by inaccurate laser ablation positions are reduced, and the success rate is increased.

Description

Technical Field

[0001] The present invention relates to intravascular optical coherence tomography technology, and in particular to a laser ablation catheter guided by optical imaging. Background Art

[0002] Currently, intravascular optical coherence tomography, namely Optical Coherence Tomography, abbreviated as OCT, is a medical imaging technology based on an imaging catheter, which can image the surface and underlying structures of blood vessels, observe the microscopic structure of the vessel wall, and help analyze and understand the nature of plaques and the stenosis of the vessel lumen, thereby facilitating clinicians to formulate appropriate interventional treatment plans for patients. Under the guidance of OCT, a laser ablation catheter uses the heat released by the laser to selectively and precisely ablate lesions to achieve the purpose of treating stenosis.

[0003] The patent document with the application number "CN201611004118.7" discloses an intravascular optical coherence tomography - photoacoustic - ultrasonic multimodal imaging device and method. The device includes a computer, an OCT excitation and acquisition system, a photoacoustic signal excitation and acquisition system, an ultrasonic signal excitation and acquisition system, and an integrated probe. The OCT excitation and acquisition system includes: a PFGA board, a superluminescent diode, an isolator, a first fiber optic coupler, a reference arm, a linear array CCD, and a first acquisition card; the photoacoustic signal excitation and acquisition system includes: a pulsed laser, a diaphragm, a second fiber optic coupler, and a double - clad fiber, and the ultrasonic signal excitation and acquisition system includes: a pulsed ultrasonic transmitter / receiver, a signal amplifier, a signal filter, and a second acquisition card; the present invention integrates three imaging modes and their respective advantages of an OCT, photoacoustic, and ultrasonic three - modal intravascular endoscopy imaging system, and can obtain multi - parameter physiological function information and multi - scale structural information of blood vessels.

[0004] The patent document with the application number "CN202110705664.8" discloses a probe integrating optical coherence tomography and intravascular ultrasound; it includes: a catheter, an integrated probe, and a coiled tube. The proximal end of the sleeve in the integrated probe is fixedly connected to the coiled tube, and a fiber optic connector, a spacer block, and a mirror sensor integrated frame are fixedly connected in sequence from the proximal end to the distal end in the sleeve. The optical fiber enters the fiber optic connector from the proximal end of the sleeve to center the optical fiber; the end face of the optical fiber is attached and fixedly connected to the surface of the proximal end of the spacer block, the proximal end of the optical fiber is connected to the fiber optic connector in the patient interaction unit, and the ultrasonic probe installed in the mirror sensor integrated frame is connected to the ultrasonic connector in the patient interaction unit through a wire. In the present invention, the relative positions of the OCT probe and the IVUS sensor are consistent during mass production, ensuring the registration of the two images. And the problem of difficult direct matching of relative positions due to different acoustic - optical emission and collection methods is solved by a separate mirror sensor integrated frame.

[0005] The above patent document, in combination with the prior art, reveals the following defects in the existing laser ablation catheter guided by optical imaging:

[0006] 1. In the treatment of carotid artery stenosis, the OCT catheter has a long access path and needs to rely on a guide wire to reach the designated position. Subsequently, the built-in probe rotates axially to form slices of the blood vessel lumen for the purpose of assisting treatment. There are two drawbacks to this imaging method: Please refer specifically to Figure 1 , the rotation starting point of the long-path access probe is completely random, making the direction of the generated pictures uncontrollable. After the subsequent laser ablation catheter enters the access, it cannot accurately align the orientation, which may lead to the risk of incorrect laser energy emission position and blood vessel rupture.

[0007] 2. Refer specifically to Figure 2 , due to the presence of the guide wire, the imaging pictures at the lesion site are incomplete and there are guide wire shadows, which affects the comprehensive judgment of the disease. Summary of the Invention

[0008] In order to overcome the deficiencies of the prior art, the present invention provides a laser ablation catheter guided by optical imaging, which solves the problems of the laser ablation catheter guided by optical imaging.

[0009] The first aspect of the present invention lies in providing a laser ablation catheter guided by optical imaging, comprising:

[0010] A laser ablation outer catheter, along the distal head of which there is a head end imaging mark arranged inside, and two positioning marks are arranged along the inner side close to the head end imaging mark. The head end imaging mark is a circular imaging material, and the positioning mark is an arc-shaped imaging material. The head end imaging mark and the positioning mark cooperate to display the head end rotation angle of the laser ablation outer catheter; a first electrical conductivity induction contact is also arranged inside the laser ablation outer catheter;

[0011] An OCT catheter, which is inserted into the laser ablation outer catheter. The OCT catheter is provided with an induction sheet for cooperating with the electrical conductivity induction contact;

[0012] A probe connection inner tube, which is arranged inside the OCT catheter. The probe connection inner tube is provided with a second electrical conductivity induction contact for cooperating with the induction sheet to confirm the relative position of the OCT inner and outer catheters;

[0013] A laser ablation catheter tail handle, which is connected to the tail of the laser ablation outer catheter. By manipulating the laser ablation catheter tail handle, the direction of the distal optical head is controlled to achieve accurate ablation of the plaque in the blood vessel.

[0014] In the first aspect of the present invention, as a preferred embodiment, each of the positioning marks forms a sector angle along the center of the laser ablation outer catheter, and the sector angle is 45°.

[0015] In the first aspect of the present invention, as a preferred embodiment, each of the positioning marks forms a sector median line along the middle part, and the sector median lines of the two positioning marks are 90°.

[0016] In the first aspect of the present invention, as a preferred embodiment, the diameters of the laser ablation outer catheter, the OCT catheter, and the probe connection inner tube decrease in sequence.

[0017] In the first aspect of the present invention, as a preferred embodiment, the laser ablation outer catheter or the probe connection inner tube is a composite tube with an intermediate layer.

[0018] In the first aspect of the present invention, as a preferred embodiment, the intermediate layer of the composite tube is made by a braiding process.

[0019] In the first aspect of the present invention, as a preferred embodiment, the width of the head end imaging mark is smaller than the width of the positioning mark.

[0020] In the first aspect of the present invention, as a preferred embodiment, the front end of the probe connection inner tube is connected with a probe assembly.

[0021] In the first aspect of the present invention, as a preferred embodiment, the induction sheet is located between the first conductivity induction contact point and the second conductivity induction contact point.

[0022] In the first aspect of the present invention, as a preferred embodiment, both the first conductivity induction contact point and the second conductivity induction contact point are connected with a connecting piece.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] 1. A closed-loop angular positioning imaging laser ablation catheter that can closely combine the laser ablation position with the OCT image, which is used for carotid plaque ablation, thereby reducing the surgical trauma caused by inaccurate laser ablation position and ensuring the success of treatment. Adopting a multi-component angular positioning induction design, the laser ablation outer catheter, the OCT catheter, the probe connection inner tube, and the OCT optical imaging head are all equipped with angular positioning induction points, effectively reducing the angular deviation during the imaging process and improving the image accuracy and reliability.

[0025] 2. The dual-modal image fusion technology for precise plaque ablation requires the withdrawal of the OCT catheter when the ablation catheter is in operation. Therefore, the calibrated OCT image is a static image generated based on historical data, while the positioning markers are used to generate real-time dynamic DSA images. By combining the two, precise plaque ablation operations with zero deviation are achieved, ensuring the accuracy and safety of the treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Schematic diagram of problem points in the prior art;

[0027] Figure 2 Schematic diagram of problem points in another prior art;

[0028] Figure 3 Structural diagram of the present invention;

[0029] Figure 4 For Figure 3 Schematic diagram of the A-A cross-section in

[0030] Figure 5 For Figure 3 Schematic diagram of the B-B cross-section in

[0031] Figure 6 Structural diagram of the OCT catheter;

[0032] Figure 7 External shape diagram of the present invention;

[0033] Figure 8 Developing image showing the rotation angle of the head end of the laser ablation catheter;

[0034] Figure 9 Schematic diagram of signal transmission;

[0035] Figure 10 Schematic diagram of the operation of the laser ablation catheter under optical imaging guidance;

[0036] Figure 11 Schematic diagram of the connection between the laser ablation outer catheter and the probe connecting inner tube.

[0037] In the figure: 10. Laser ablation outer catheter; 101. Head end developing marker; 102. Positioning marker; 1021. Sector angle; 1022. Sector median line; 11. First conductance induction contact; 20. OCT catheter; 21. Induction sheet; 30. Probe connecting inner tube; 31. Second conductance induction contact; 40. Laser ablation catheter tail handle. DETAILED DESCRIPTION OF THE INVENTION

[0038] Next, in combination with the accompanying drawings and specific embodiments, the invention will be further described. It should be noted that, on the premise of non-conflict, any combination of the following-described embodiments or technical features can form a new embodiment. Unless otherwise specified, the materials and equipment used in this embodiment can be purchased from the market. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below by referring to the accompanying drawings are exemplary and are only used to explain the present application, and should not be construed as a limitation to the present application.

[0039] In the description of the present application, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present application. In the description of the present application, "a plurality of" means two or more, unless otherwise specifically and precisely defined.

[0040] In the description of the present application, it should be noted that unless otherwise clearly specified and defined, the terms "connected", "communicated", "connected" should be understood in a broad sense. For example, it can be a fixed connection, or can be connected through an intermediate medium, and can be the communication inside two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific situations.

[0041] The terms "first", "second", etc. in the description, claims and above-mentioned drawings of the present application are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device comprising a series of steps or units does not necessarily have to be limited to those steps or units clearly listed, but may include other steps or units not clearly listed or inherent to these processes, methods, products or devices.

[0042] Such as Figure 3-7As shown in the figure, an optical imaging-guided laser ablation catheter includes a laser ablation outer catheter 10, an OCT catheter 20, a probe connection inner tube 30, and a laser ablation catheter tail handle 40. A head end imaging mark 101 is provided along the distal head inside the laser ablation outer catheter 10, and two positioning marks 102 are provided along the inner side close to the head end imaging mark 101. The head end imaging mark 101 is a circular imaging material, and the positioning mark 102 is an arc-shaped imaging material. The head end imaging mark 101 and the positioning mark 102 cooperate to display the head end rotation angle of the laser ablation outer catheter 10. A first electrical conductivity induction contact 11 is also provided inside the laser ablation outer catheter 10. The OCT catheter 20 is inserted into the laser ablation outer catheter 10, and the OCT catheter 20 is provided with an induction sheet 21 for cooperating with the electrical conductivity induction contact. The probe connection inner tube 30 is arranged inside the OCT catheter 20, and the probe connection inner tube 30 is provided with a second electrical conductivity induction contact 31 for confirming the relative position of the OCT inner and outer catheters in cooperation with the induction sheet 21. The laser ablation catheter tail handle 40 is connected to the tail of the laser ablation outer catheter 10, and the direction of the distal optical guide head is controlled by manipulating the laser ablation catheter tail handle 40 to achieve accurate ablation of plaques in blood vessels. A closed-loop angular positioning imaging laser ablation catheter that can closely combine the laser ablation position with the OCT image is used for carotid plaque ablation, thereby reducing the surgical trauma caused by inaccurate laser ablation positions and improving the success rate.

[0043] Please refer specifically to Figure 8 , which is an imaging diagram for showing the rotation angle of the head end of the laser ablation catheter. The head end imaging mark 101 is used to prompt the real-time head end position of the catheter, and the positioning mark 102 is used to indicate the angular state of the catheter head end at this time, keeping the angular displacement of the ablation catheter unchanged under DSA. The positioning mark 102 is composed of two arc-shaped imaging materials at a 45-degree angle, with a 90-degree interval between them, located at the head end of the catheter, and is used to display the rotation angle of the head end of the laser ablation catheter.

[0044] Specifically, when the first electrical conductivity induction contact 11 provided on the laser ablation outer catheter 10 and the induction sheet 21 provided on the OCT catheter 20 rotate relative to each other to a certain angle, the first electrical conductivity induction contact 11 and the induction sheet 21 are in contact and coincide, generating an electrical signal.

[0045] Specifically, for the second electrical conductivity induction contact 31 provided on the probe connection inner tube 30 for confirming the relative position of the OCT inner and outer catheters, there is a scale alignment every time the OCT catheter rotates one circle, and the signal transmission is shown as Figure 9As shown, when neither the first conductivity induction contact 11 nor the second conductivity induction contact 31 is in contact with the induction sheet 21, both are at a high level or a low level; after the first conductivity induction contact 11 and the second conductivity induction contact 31 come into contact with the induction sheet 21, the level is reversed. After the position of the laser ablation catheter is corrected in combination with the OCT image, the direction of the distal light guide head is controlled by manipulating the handle 40 at the tail of the laser ablation catheter to achieve accurate ablation of the plaque in the blood vessel.

[0046] Specifically, Figure 10 is a schematic diagram of the operation of a laser ablation catheter under optical imaging guidance. The surgical process is as Figure 10 shown. This closed-loop angular positioning imaging laser ablation catheter can be used in conjunction with a double-balloon occlusion catheter, a blood reflux protection device. It can be inserted through the carotid artery approach. By shortening the path, the angular error of the rotation of the probe of the laser ablation catheter can be effectively reduced, and the head end of the OCT catheter can be made soft accordingly so that it can reach the corresponding position without using a guide wire, thereby eliminating the adverse factor of the guide wire shadow in the image.

[0047] Technical effects:

[0048] 1. Adopting a multi-component angular positioning induction design, the laser ablation outer catheter 10, the OCT catheter 20, the probe connecting inner tube 30, and the OCT optical imaging head are all equipped with angular positioning induction points, effectively reducing the angular deviation during the imaging process and improving the image accuracy and reliability.

[0049] 2. Adopting a dual-modal image fusion technology for accurate plaque ablation. When the ablation catheter is working, the OCT catheter needs to be withdrawn. Therefore, the calibrated OCT image is a static image generated based on historical data, while the positioning mark 102 is used to generate a DSA real-time dynamic image. By combining the two, an accurate plaque ablation operation with zero deviation is achieved, ensuring the accuracy and safety of the treatment.

[0050] In the first aspect of the present invention, as a preferred embodiment, each of the positioning marks 102 forms a sector angle 1021 along the center of the laser ablation outer catheter 10, and the sector angle 1021 is 45°.

[0051] Specifically, each of the positioning marks 102 forms a sector median line 1022 along the middle, and the sector median lines 1022 of the two positioning marks 102 are 90°, which is convenient for identification.

[0052] In the first aspect of the present invention, as a preferred embodiment, the diameters of the laser ablation outer catheter 10, the OCT catheter 20, and the probe connecting inner tube 30 decrease in sequence. Preferably, the width of the head end imaging mark 101 is smaller than the width of the positioning mark 102. Preferably, the induction sheet 21 is located between the first conductivity induction contact 11 and the second conductivity induction contact 31.

[0053] In a first aspect of the present invention, as a preferred embodiment, please refer to Figure 11 , the laser ablation outer catheter 10 or the probe connecting inner tube 30 is a composite tube with an intermediate layer.

[0054] In a first aspect of the present invention, as a preferred embodiment, the intermediate layer of the composite tube is made by a braiding process. With the intermediate layer made by the braiding process, excellent torque control can be achieved through braiding reinforcement. The size, profile, density PPI, and braiding configuration of the braiding wires can be designed to find a balance between good thrust performance and good torque control. For the optimization design of the front end of the OCT outer tube, the front end of the OCT outer catheter is subjected to softening treatment, having the characteristic of soft-hardness gradient change, enabling it to flexibly meet the requirements of short-distance vascular superselection or crossing lesions, and significantly improving the convenience and success rate of surgical operations.

[0055] In a first aspect of the present invention, as a preferred embodiment, a probe assembly is connected to the front end of the probe connecting inner tube 30. Specifically, the first conductance induction contact 11 and the second conductance induction contact 31 are both connected to a connecting member.

[0056] The above embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention fall within the scope of protection required by the present invention.

Claims

1. A laser ablation catheter guided by optical imaging, characterized in that: include: A laser ablation outer catheter, wherein a head end developing mark is arranged along the distal head of the inner side of the laser ablation outer catheter, and two positioning marks are arranged along the inner side close to the head end developing mark, the head end developing mark is a ring-shaped developing material, and the positioning mark is an arc-shaped developing material, and the head end developing mark cooperates with the positioning mark to display the head end rotation angle of the laser ablation outer catheter; a first conductivity sensing contact is also arranged in the laser ablation outer catheter; An OCT catheter, the OCT catheter is inserted into the laser ablation outer catheter, and the OCT catheter is provided with a sensing sheet for cooperating with a conductivity sensing contact; The probe is connected to the inner tube, and the probe is connected to the inner tube, which is arranged in the OCT catheter. The probe is connected to the inner tube and is provided with a second conductivity sensing contact that cooperates with the sensing sheet and is used to confirm the relative position of the inner and outer catheters of the OCT; The laser ablation catheter tail handle is connected to the tail of the laser ablation outer catheter. The direction of the distal light guide head is controlled by manipulating the laser ablation catheter tail handle to achieve accurate ablation of intravascular plaques.

2. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: Each of the positioning marks forms a fan-shaped angle along the center of the laser ablation outer catheter, and the fan-shaped angle is 45°.

3. The optical imaging-guided laser ablation catheter according to claim 2, characterized in that: Each positioning mark forms a fan-shaped center line along the middle, and the fan-shaped center lines of the two positioning marks are 90 degrees.

4. The optical imaging-guided laser ablation catheter according to claim 2, characterized in that: The diameters of the laser ablation outer catheter, the OCT catheter, and the probe connecting inner tube decrease in sequence.

5. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: The laser ablation outer catheter or the probe connection inner tube is a composite tube with an intermediate layer.

6. The optical imaging-guided laser ablation catheter according to claim 5, characterized in that: The middle layer of the composite pipe is made by a weaving process.

7. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: The width of the head end developing mark is smaller than the width of the positioning mark.

8. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: The front end of the probe connecting inner tube is connected with a probe assembly.

9. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: The sensing sheet is located between the first conductive sensing contact and the second conductive sensing contact.

10. The optical imaging-guided laser ablation catheter according to claim 1, characterized in that: The first conductivity sensing contact and the second conductivity sensing contact are both connected to a connecting piece.

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