Collagen peptide capable of delaying senescence as well as preparation method and application of collagen peptide

Abstract

The invention provides collagen peptide capable of delaying senescence and a preparation method and application thereof, and belongs to the technical field of biological health care, in the aspect of efficacy, fish skin collagen, vitamin C and grape seed extract have a synergistic effect, the senescence delaying effect is improved, the fish skin collagen provides sufficient supplement for a human body, and the effect of delaying senescence is achieved. The vitamin C resists free radicals and promotes collagen synthesis, the grape seed extract enhances oxidation resistance, the preparation method is scientific and reasonable, easy to operate and low in cost, temperature, stirring speed and the like are controlled to ensure sufficient dissolution and reaction, the product purity and quality are improved, and the preparation method is stable, suitable for large-scale production and wide in application prospect. The composition can be used for various cosmetics and health food dosage forms, meets individual requirements, achieves the purpose of delaying senescence, and has great practical value and market prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of biological health care, and particularly relates to a collagen peptide for delaying aging, its preparation method and application. Background Art

[0002] With the improvement of people's living standards and the increasing attention to health and beauty, delaying aging has become an urgent need for many consumers. Collagen is an important component of human tissues such as skin, bones, and joints. As people age, the synthesis of human collagen gradually decreases, and the loss rate accelerates, resulting in aging phenomena such as loose skin, increased wrinkles, and joint pain. Therefore, supplementing collagen has become an effective method for delaying aging.

[0003] At present, there are a variety of collagen products on the market, but there are some deficiencies. On the one hand, the effect of pure collagen products in delaying aging is limited, and they need to cooperate with other active ingredients to better play their efficacy. On the other hand, the existing preparation methods of collagen peptides have problems such as complex processes, high costs, and unstable product quality.

[0004] To solve the above problems, the present invention provides a collagen peptide for delaying aging, its preparation method and application. The collagen peptide is composed of fish skin collagen, vitamin C, and grape seed extract. By precisely controlling parameters such as temperature and time in the preparation process, a collagen peptide with a molecular weight of 1000 - 3000 Daltons is prepared, which has good biocompatibility and absorbability and can effectively delay aging. At the same time, the preparation method of the present invention is simple, low-cost, and the product quality is stable, with broad market prospects. Summary of the Invention

[0005] The purpose of the present invention is to provide a collagen peptide for delaying aging, its preparation method and application, aiming to solve the problems in the prior art.

[0006] To achieve the above purpose, the present invention provides the following technical solutions:

[0007] A collagen peptide for delaying aging, characterized in that the collagen peptide is prepared from the following raw materials in parts by weight: 80 - 100 parts of fish skin collagen, 5 - 10 parts of vitamin C, and 3 - 8 parts of grape seed extract. Among them, the fish skin collagen is preferably from the fish skin of deep-sea fish, which is rich in collagen, has good biocompatibility and absorbability. Vitamin C, as an antioxidant, can effectively resist the damage of free radicals to the skin and enhance the synthesis of collagen. The grape seed extract is rich in antioxidant components such as proanthocyanidins, further enhancing the anti-aging effect of the product.

[0008] As a preferred embodiment of the present invention, the molecular weight of the collagen peptide is 1000 - 3000 Daltons.

[0009] As a preferred embodiment of the present invention, a method for preparing a collagen peptide for anti - aging, characterized by comprising the following steps:

[0010] Step 1: Add fish - skin collagen to an appropriate amount of distilled water, stir and dissolve it at 40 - 50 °C to obtain a collagen solution. During this process, the stirring speed should be controlled moderately to ensure that the fish - skin collagen is fully dissolved while avoiding the generation of excessive bubbles;

[0011] Step 2: Add vitamin C and grape - seed extract to the collagen solution, stir and react at 50 - 60 °C for 2 - 3 hours. To ensure the full progress of the reaction, a constant - temperature stirrer can be used for stirring to ensure that the temperature is stable within the specified range;

[0012] Step 3: Cool the reacted solution to 30 - 40 °C and add an appropriate amount of stabilizer, stir evenly. The choice of stabilizer should be based on the characteristics and requirements of the product to ensure the stability of the collagen peptide;

[0013] Step 4: Ultra - filter the solution to remove impurities and macromolecular substances to obtain a pure collagen peptide solution. During the ultra - filtration process, the pressure and flow rate should be controlled to ensure the filtration effect;

[0014] Step 5: Concentrate the collagen peptide solution to reach a certain concentration requirement. Vacuum concentration and other methods can be used to avoid affecting the activity of the collagen peptide due to excessive temperature;

[0015] Step 6: Spray - dry the concentrated solution to obtain collagen peptide powder. The parameters of spray - drying should be adjusted according to the characteristics of the product to ensure the quality and uniform particle size of the powder.

[0016] As a preferred embodiment of the present invention, in Step 2, the reaction temperature is 55 °C and the reaction time is 2.5 hours. Under these temperature and time conditions, vitamin C and grape - seed extract can react fully with collagen and play the best synergistic effect.

[0017] As a preferred embodiment of the present invention, cosmetics can include various forms such as creams, lotions, serums, masks, etc. In cosmetics, the collagen peptide can increase the elasticity and firmness of the skin, reduce the generation of wrinkles and fine lines, and make the skin smoother and more delicate. Different forms of cosmetics can adjust the addition amount and formula of the collagen peptide according to their characteristics and usage requirements to achieve the best anti - aging effect.

[0018] As a preferred embodiment of the present invention, the dosage forms of the health food may include tablets, capsules, oral liquids, etc. In the health food, collagen peptides can supplement the collagen required by the human body, promote the synthesis of collagen, increase the water content of the skin, enhance the body's immunity, so as to achieve the purpose of delaying aging. Health foods of different dosage forms can be selected according to their characteristics and the target user groups to facilitate consumers' taking and absorption.

[0019] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0020] In terms of efficacy, this collagen peptide is composed of fish skin collagen, vitamin C, and grape seed extract. The three components work synergistically to greatly enhance the anti-aging effect. The fish skin collagen is preferably selected from the fish skin of deep-sea fish, rich in collagen, with good biocompatibility and absorbability, and can provide sufficient collagen supplementation for human skin, bones and other tissues, increasing skin elasticity and firmness, reducing the generation of wrinkles and fine lines, making the skin smoother and more delicate, and at the same time nourishing joints and other parts. As a powerful antioxidant, vitamin C effectively resists the damage of free radicals to the skin, reduces the damage of oxidative stress to cells, and can enhance the synthesis of collagen, promoting the production of collagen in the human body. The grape seed extract is rich in antioxidant components such as proanthocyanidins, further enhancing the antioxidant capacity of the product, reducing cell aging, and jointly achieving the anti-aging effect from multiple angles. Secondly, it has obvious advantages in the preparation method. The preparation process from step one to step six is scientific, reasonable and easy to operate. When dissolving fish skin collagen, the temperature and stirring speed are controlled to ensure complete dissolution without generating too many bubbles, laying a good foundation for subsequent reactions. In step two, the reaction temperature and time are precisely controlled to enable vitamin C and grape seed extract to fully react with collagen, exerting the best synergistic effect. Cooling treatment and adding stabilizers ensure the stability of the collagen peptide. Ultrafiltration treatment removes impurities and macromolecular substances to obtain a pure collagen peptide solution, improving the purity and quality of the product. Methods such as vacuum concentration and spray drying are used, which not only avoid the influence of too high temperature on the activity of collagen peptide, but also ensure the quality and particle size uniformity of the powder. The overall preparation method is simple, with low cost and stable product quality, suitable for large-scale production. Finally, it has a wide range of application prospects. In the cosmetics field, it can be applied in various forms such as creams, lotions, serums, masks, etc. Different forms of cosmetics can adjust the addition amount and formula of collagen peptide according to their characteristics and usage requirements to meet the personalized needs of different consumers. In the health food field, there are various dosage forms, including tablets, capsules, oral liquids, etc., which are convenient for consumers to choose the taking method according to their own conditions, better supplement the collagen required by the human body, promote collagen synthesis, increase the skin moisture content, enhance the body immunity, and achieve the purpose of anti-aging. In summary, the anti-aging collagen peptide of the present invention, its preparation method and application have great practical value and broad market prospects. Detailed implementation manners

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0022] Example 1

[0023] The present invention provides the following technical solutions:

[0024] A collagen peptide for anti-aging, characterized in that the collagen peptide is prepared from the following raw materials in parts by weight: 80-100 parts of fish skin collagen, 5-10 parts of vitamin C, and 3-8 parts of grape seed extract. Among them, the fish skin collagen is preferably from the fish skin of deep-sea fish, which is rich in collagen, has good biocompatibility and absorbability. Vitamin C, as an antioxidant, can effectively resist the damage of free radicals to the skin and enhance the synthesis of collagen. The grape seed extract is rich in antioxidant components such as proanthocyanidins, further enhancing the anti-aging effect of the product.

[0025] In a specific embodiment of the present invention, the collagen peptide is composed of specific parts by weight of fish skin collagen, vitamin C and grape seed extract. The fish skin collagen is preferably from the fish skin of deep-sea fish. The pure deep-sea environment endows the fish skin collagen with extremely high quality. Its rich collagen content provides sufficient nutritional supplementation for human skin, bones and other tissues. Good biocompatibility and absorbability ensure that the human body can utilize it efficiently. Vitamin C, as an antioxidant, can effectively resist the damage of free radicals to the skin, reduce the damage of oxidative stress to cells, and at the same time enhance the synthesis of collagen, providing double protection for the skin. The grape seed extract is rich in antioxidant components such as proanthocyanidins, further enhancing the antioxidant capacity of the product, reducing cell aging. The three components work together synergistically to achieve the anti-aging effect from multiple angles, bringing significant skin care and health care effects to consumers.

[0026] Specifically, the molecular weight of the collagen peptide is 1000-3000 Daltons.

[0027] In this example: The collagen peptide within this molecular weight range is more easily absorbed and utilized by the human body. The smaller molecular weight enables it to penetrate the skin barrier more quickly and reach the bottom layer of the skin, providing the required collagen nutrition for skin cells. In terms of health care, it can also be better absorbed by the digestive system, playing a role in supplementing human collagen and promoting collagen synthesis. This specific molecular weight of collagen peptide can more effectively increase the elasticity and firmness of the skin, reduce the generation of wrinkles and fine lines, and make the skin smoother and more delicate. At the same time, it can also play a better nourishing role in joints and other parts, improving the flexibility and comfort of joints, providing strong guarantee for people's health and beauty.

[0028] Specifically, a preparation method of a collagen peptide for anti-aging, characterized by comprising the following steps:

[0029] Step 1: Add fish skin collagen into an appropriate amount of distilled water and stir to dissolve it at 40 - 50 °C to obtain a collagen solution. During this process, the stirring speed should be controlled moderately to ensure the full dissolution of fish skin collagen while avoiding excessive bubble generation;

[0030] Step 2: Add vitamin C and grape seed extract into the collagen solution and stir and react at 50 - 60 °C for 2 - 3 hours. To ensure the full progress of the reaction, a constant temperature stirrer can be used for stirring to ensure that the temperature is stable within the specified range;

[0031] Step 3: Cool down the reacted solution to 30 - 40 °C and add an appropriate amount of stabilizer, then stir evenly. The choice of stabilizer should be based on the characteristics and requirements of the product to ensure the stability of collagen peptides;

[0032] Step 4: Ultrafilter the solution to remove impurities and macromolecular substances to obtain a pure collagen peptide solution. During the ultrafiltration process, the pressure and flow rate should be controlled to ensure the filtration effect;

[0033] Step 5: Concentrate the collagen peptide solution to reach a certain requirement. Vacuum concentration and other methods can be used to avoid affecting the activity of collagen peptides due to excessive temperature;

[0034] Step 6: Spray - dry the concentrated solution to obtain collagen peptide powder. The parameters of spray - drying should be adjusted according to the characteristics of the product to ensure the quality and uniform particle size of the powder.

[0035] In this embodiment: In Step 1, fish skin collagen is added to an appropriate amount of distilled water, and the temperature is controlled at 40 - 50 °C and dissolved at a moderate stirring speed. This not only ensures the full dissolution of fish skin collagen but also avoids the generation of excessive bubbles, creating good conditions for subsequent reactions. The precise control of this step helps maintain the activity of collagen, enabling it to play a better role in subsequent processes. In Step 2, the reaction temperature and time are precisely controlled to allow vitamin C and grape seed extract to fully react with collagen and exert the best synergistic effect. The use of a thermostatic stirrer ensures temperature stability, guaranteeing the consistency and efficiency of the reaction. In Step 3, after cooling and adding a stabilizer, the stability of collagen peptides is effectively ensured, making them less likely to deteriorate during subsequent processing and storage, and extending the product's shelf life. In Step 4, the ultrafiltration treatment strictly controls the pressure and flow rate to remove impurities and macromolecular substances, obtaining a pure collagen peptide solution, improving the purity and quality of the product, and reducing factors that may have adverse effects on the human body. In Step 5, the vacuum concentration method is used to avoid the influence of excessive temperature on the activity of collagen peptides, while bringing the solution concentration to a certain requirement, preparing for subsequent spray drying. In Step 6, the spray drying parameters are adjusted according to the product characteristics to obtain collagen peptide powder with uniform quality and particle size, facilitating the packaging, transportation, and use of the product. The overall preparation method is scientific, reasonable, and easy to operate. It not only ensures the stable quality of the product but also reduces production costs, is suitable for large-scale production, and provides high-quality and cost-effective anti-aging products for the market.

[0036] Specifically, in Step 2, the reaction temperature is 55 °C and the reaction time is 2.5 hours. Under these temperature and time conditions, vitamin C and grape seed extract can fully react with collagen and exert the best synergistic effect.

[0037] In this embodiment: Under these temperature and time conditions, vitamin C and grape seed extract can fully react with collagen and exert the best synergistic effect. The precise control of temperature ensures that the reaction rate and degree are moderate, neither causing the destruction of active ingredients due to excessive temperature nor making the reaction incomplete due to too low temperature. The 2.5-hour reaction time guarantees sufficient time for the three components to interact with each other and form a stable complex. This optimal reaction condition maximizes the efficacy of collagen peptides, providing a strong guarantee for the anti-aging effect of the product. At the same time, this specific reaction condition also provides a clear standard for quality control during the production process, facilitating the assurance of product consistency and stability.

[0038] Specifically, cosmetics can include various forms such as creams, lotions, serums, masks, etc. In cosmetics, collagen peptides can increase the elasticity and firmness of the skin, reduce the appearance of wrinkles and fine lines, and make the skin smoother and more delicate. Different forms of cosmetics can adjust the addition amount and formula of collagen peptides according to their characteristics and usage requirements to achieve the best anti-aging effect.

[0039] In this embodiment: Collagen peptides can increase the elasticity and firmness of the skin, reduce the appearance of wrinkles and fine lines, and make the skin smoother and more delicate. Applying it to various forms of cosmetics such as creams, lotions, serums, masks, etc. can meet the personalized needs of different consumers. For creams, appropriately increasing the content of collagen peptides can enhance their moisturizing and firming effects on the skin, providing deep nourishment for dry and mature skin. Lotions can provide collagen supplementation to the skin while maintaining a light texture, making the skin more hydrated and shiny. The high-concentration collagen peptides in serums can penetrate more quickly to the bottom layer of the skin, playing a role in repair and anti-aging. As a concentrated care product, the combination of masks and collagen peptides can enable the skin to absorb more nutrients in a short time and quickly improve the skin condition. Different forms of cosmetics can adjust the addition amount and formula of collagen peptides according to their characteristics and usage requirements, providing more choices for consumers, meeting the needs of different skin types and age groups, and bringing a new experience to people's skin care.

[0040] Specifically, the dosage forms of health foods can include tablets, capsules, oral liquids, etc. In health foods, collagen peptides can supplement the collagen required by the human body, promote the synthesis of collagen, increase the water content of the skin, and enhance the body's immunity, thereby achieving the purpose of anti-aging. Different dosage forms of health foods can be selected according to their characteristics and the target population to facilitate consumers' taking and absorption.

[0041] In this embodiment: Collagen peptides can supplement the collagen required by the human body, promote the synthesis of collagen, increase the water content of the skin, and enhance the body's immunity, thereby achieving the purpose of anti-aging. Making it into various dosage forms such as tablets, capsules, oral liquids, etc. facilitates consumers to choose the taking method according to their own situation. Tablets have the advantages of being convenient to carry and accurate in dosage, and are suitable for daily taking. Capsules can protect collagen peptides from the influence of the external environment and improve their stability. Oral liquids are more easily absorbed by the human body and act quickly. Different dosage forms of health foods can meet the needs of different consumers. Whether it is busy office workers or the elderly, they can find a taking method suitable for themselves. The application of such multiple dosage forms provides consumers with a more convenient and efficient health care option, helping people better maintain a healthy state and delay the aging process.

[0042] The working principle and usage process of the present invention:

[0043] First, in the raw material selection stage, carefully select the fish skin of deep-sea fish as the source of collagen. Deep-sea fish grow in a pure marine environment, and their fish skin is rich in a large amount of high-quality collagen, with good biocompatibility and absorbability. At the same time, prepare vitamin C and grape seed extract. As a powerful antioxidant, vitamin C can effectively resist the damage of free radicals to the skin, while grape seed extract is rich in antioxidant components such as proanthocyanidins, further enhancing the antioxidant capacity of the product. Then, enter the preparation stage. Step 1, add fish skin collagen to an appropriate amount of distilled water, control the temperature at 40 - 50°C, and stir and dissolve it at a moderate stirring speed. During this process, the operator needs to closely monitor the stirring situation to ensure that the fish skin collagen is fully dissolved while avoiding the generation of excessive bubbles, laying a good foundation for the subsequent reaction. Step 2, add vitamin C and grape seed extract to the collagen solution, use a constant temperature stirrer to keep the temperature stable at 50 - 60°C, and stir and react for 2 - 3 hours to ensure that the three components fully react and play the best synergistic effect. Step 3, cool down the reacted solution to make its temperature drop to 30 - 40°C, and select a suitable stabilizer according to the product characteristics and requirements and add it to the solution, stirring evenly to ensure the stability of collagen peptides. Step 4, perform ultrafiltration treatment on the solution, strictly control the pressure and flow rate, remove impurities and macromolecular substances, and obtain a pure collagen peptide solution. Step 5, concentrate the collagen peptide solution by vacuum concentration to avoid the influence of too high temperature on the activity of collagen peptides and make its concentration reach certain requirements. Step 6, adjust the parameters of spray drying according to the product characteristics, and perform spray drying on the concentrated solution to obtain collagen peptide powder with uniform quality and particle size. Finally, in the application stage, on the one hand, in the cosmetics field, this collagen peptide can be applied in various forms such as creams, lotions, serums, masks, etc. R & D personnel adjust the addition amount and formula of collagen peptides according to the characteristics and usage requirements of different cosmetics. For example, in creams, the content of collagen peptides can be appropriately increased to enhance its moisturizing and firming effects on the skin; in masks, attention is paid to the combination of collagen peptides with other moisturizing components to enable the skin to absorb more nutrients in a short time. On the other hand, in the health food field, this collagen peptide can be made into various dosage forms such as tablets, capsules, oral liquids, etc. Consumers can choose a convenient way to take it according to their own situations to better supplement the collagen required by the human body, promote collagen synthesis, increase the skin moisture content, enhance the body's immunity, and thus achieve the purpose of delaying aging. In short, the anti-aging collagen peptide of the present invention provides consumers with an efficient and safe anti-aging solution through a scientific and reasonable operation process.

[0044] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A collagen peptide for delaying aging, characterized in that: The collagen peptide is prepared from the following raw materials in parts by weight: 80-100 parts of fish skin collagen, 5-10 parts of vitamin C, and 3-8 parts of grape seed extract. The fish skin collagen is preferably obtained from the skin of deep-sea fish, which is rich in collagen and has good biocompatibility and absorbability. Vitamin C, as an antioxidant, can effectively resist the damage of free radicals to the skin and enhance the synthesis of collagen. The grape seed extract is rich in antioxidant ingredients such as proanthocyanidins, which further enhances the anti-aging effect of the product.

2. The collagen peptide for delaying aging according to claim 1, characterized in that: The molecular weight of the collagen peptide is 1000-3000 Daltons.

3. The method for preparing the anti-aging collagen peptide according to claim 2, characterized in that: The following steps are involved: Step 1: Add fish skin collagen to an appropriate amount of distilled water, stir and dissolve at 40-50°C to obtain a collagen solution. During this process, the stirring speed must be controlled to be moderate to ensure that the fish skin collagen is fully dissolved while avoiding the generation of excessive bubbles; Step 2: Add vitamin C and grape seed extract to the collagen solution, stir and react at 50-60°C for 2-3 hours. To ensure the reaction is fully carried out, a constant temperature stirrer can be used for stirring to ensure that the temperature is stable within the specified range; Step 3: Cool the solution after the reaction to 30-40°C, add an appropriate amount of stabilizer, and stir evenly. The choice of stabilizer should be based on the characteristics and requirements of the product to ensure the stability of the collagen peptide; Step 4: Ultrafiltration is performed on the solution to remove impurities and macromolecular substances to obtain a pure collagen peptide solution. The pressure and flow rate should be controlled during the ultrafiltration process to ensure the filtration effect; Step 5: Concentrate the collagen peptide solution to a certain concentration requirement. Vacuum concentration and other methods may be used to avoid the effect of excessive temperature on the activity of the collagen peptide. Step 6: Spray dry the concentrated solution to obtain collagen peptide powder. The spray drying parameters should be adjusted according to the characteristics of the product to ensure uniform quality and particle size of the powder.

4. The method for preparing the anti-aging collagen peptide according to claim 3, characterized in that: In step 2, the reaction temperature is 55° C. and the reaction time is 2.5 hours. Under this temperature and time condition, vitamin C and grape seed extract can fully react with collagen and exert the best synergistic effect.

5. According to the application of the anti-aging collagen peptide according to claim 4, the cosmetics may include various forms such as creams, lotions, essences, masks, etc. In cosmetics, collagen peptides can increase the elasticity and firmness of the skin, reduce the formation of wrinkles and fine lines, and make the skin smoother and more delicate. Different forms of cosmetics can adjust the addition amount and formula of collagen peptides according to their characteristics and usage requirements to achieve the best anti-aging effect.

6. The use of the collagen peptide for delaying aging in health food according to claim 5, the dosage form of the health food may include tablets, capsules, oral liquids, etc. In health food, collagen peptide can supplement the collagen required by the human body, promote the synthesis of collagen, increase the moisture content of the skin, and enhance the body's immunity, thereby achieving the purpose of delaying aging. Health foods of different dosage forms can be selected according to their characteristics and user groups, so as to facilitate consumers to take and absorb.