Traditional Chinese medicine composition for treating severe plateau cold as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating plateau severe cold as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The invention provides a traditional Chinese medicine composition aiming at the problems that the treatment effect is poor and the treatment course is long when western medicines are used for treating the severe plateau cold, most of patients need at least one week, a few of patients need 2-3 weeks to relieve the severe plateau cold, the patients are absent for 10 days on average, and construction work, parent tourism exploration, daily life and the like in plateau areas are seriously influenced. The traditional Chinese medicine is characterized by being prepared from the following raw materials in parts by weight: 20 parts of Chinese waxgourd seeds, 10 parts of radix saposhnikoviae, 10 parts of folium eriobotryae, 10 parts of perilla leaves, 2 parts of asarum, 10 parts of almonds, 10 parts of platycodon grandiflorum, 5 parts of radix peucedani, 15 parts of agastache rugosus, 15 parts of poria cocos, 10 parts of biond magnolia flowers, 20 parts of rhizoma phragmitis, 10 parts of ligusticum wallichii and 5 parts of thunberg fritillary bulbs. The traditional Chinese medicine composition can remarkably inhibit release of inflammatory factors, relieve airway hyperreactivity, ventilate the lung, relieve exterior syndrome to dispel exogenous evil, reduce phlegm, clear damp to smooth lung qi, and accord with the pathogenic characteristics of low oxygen, high cold, windy wind and heavy dampness of plateau.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating severe colds in high altitudes, and a preparation method and application thereof. Background Art

[0002] A cold, known as "common cold" in traditional Chinese medicine, belongs to the category of exogenous superficial syndromes. Traditional medicine believes that this disease is mostly caused by exogenous pathogenic factors such as wind combined with cold, heat, and dampness invading the lung and defensive qi, resulting in disharmony between nutrient qi and defensive qi, and failure of the lung to disperse and descend. However, due to the unique geographical and climatic characteristics of high altitude areas, the pathogenesis of colds shows special changes. The high altitude environment is characterized by "high cold, low oxygen, strong wind, and heavy dampness", which is prone to form a special pathological pattern of "combined disease of wind-cold-dampness".

[0003] The syndrome characteristics of severe colds in high altitude environments: mostly present a complex syndrome of "unresolved exterior cold and interior dampness has occurred", manifested as follows: In the initial stage: wind-cold attacking the exterior, defensive yang being checked (nasal congestion with clear nasal discharge, aversion to cold and headache); In the middle stage: damp pathogen stagnating the spleen, failure of the lung to disperse and descend (cough with white phlegm, abdominal distension and loose stools); In the later stage: transformation of dampness into heat, phlegm-heat congesting the lung (yellow and sticky phlegm, dry mouth but not willing to drink). Pulse diagnosis mostly shows the signs of taut and tight or soggy and slippery, and the tongue image is mainly characterized by white greasy or yellow greasy coating, which is an obvious evidence of "internal accumulation of damp turbidity and qi stagnation". Modern research has confirmed that this pathological state is closely related to the hyperactive inflammatory response and immune function disorder under the high altitude hypoxia environment.

[0004] Limitations of Western medicine treatment and advantages of traditional Chinese medicine: Although Western medicines (such as compound codeine phosphate solution, ambroxol oral liquid) can relieve symptoms, they have obvious limitations. Clinical observations have found that the effective rate of Western medicine in treating severe colds in high altitude environments is only 60%, the average course of treatment reaches 10 days, and it is easy to relapse. The reason lies in that simple antiviral or symptomatic treatment is difficult to take into account the complex pathogenesis of high altitude colds of "simultaneous exterior and interior diseases, deficiency and excess mixed". Summary of the Invention

[0005] In view of the long treatment course and poor curative effect of Western medicine in treating severe colds in high altitude environments in the prior art, and the fact that the vast majority of patients need at least 1 week to relieve, and a few patients need 2 - 3 weeks for the symptoms to start to relieve, with the symptoms recurring repeatedly, the present invention provides a traditional Chinese medicine composition for treating severe colds in high altitudes, and a preparation method and application thereof. Since traditional Chinese medicine treatment emphasizes "overall regulation and treatment, taking into account both the symptoms and the root cause", in view of the particularity of high altitude colds, the treatment method should be "relieving exterior cold, strengthening the spleen and resolving dampness, and dispersing the lung and resolving phlegm". By regulating nutrient qi and defensive qi, smoothing qi movement, strengthening the healthy qi and eliminating pathogenic factors, it can effectively improve symptoms, shorten the course of disease, and prevent transmission. This treatment strategy fully embodies the academic thoughts of "treatment based on syndrome differentiation" and "treatment according to the three causes of disease" in traditional Chinese medicine, and has unique advantages in preventing and treating colds in high altitude areas.

[0006] The technical solution adopted by the present invention is as follows:

[0007] A traditional Chinese medicine composition for treating severe plateau cold is prepared from the following raw materials in parts by weight: 20 parts of wax gourd seeds, 10 parts of siler, 10 parts of loquat leaves, 10 parts of perilla leaves, 2 parts of asarum, 10 parts of apricot kernels, 10 parts of platycodon, 5 parts of peucedanum, 15 parts of patchouli, 15 parts of tuckahoe, 10 parts of magnolia, 20 parts of reed roots, 10 parts of ligusticum chuanxiong, and 5 parts of thunbergii bulbs.

[0008] After adopting this technical solution, this compound is based on the traditional Chinese medicine theory that "there are many wind, cold and dampness in the plateau, which can easily damage the lungs and spleen". It targets the core pathogenesis of severe colds in the plateau environment, "wind and cold bind the surface, phlegm and dampness block the lungs, and lung qi is blocked". It takes "resolving the surface and dispersing cold, promoting lung function and resolving phlegm, and strengthening spleen and removing dampness" as the main points of the prescription, and is specially designed for the special climate environment of the plateau. The formula uses Saposhnikovia divaricata, Perilla leaf, and Asarum as the main ingredients, which are pungent and warm to relieve the surface, dispel wind and dissipate cold, and open the pores to drive away the wind and cold evil in the plateau; Apricot kernel, Platycodon grandiflorum, Peucedanum chinense, and Fritillaria thunbergii are the auxiliary ingredients, which promote and descend lung qi, resolve phlegm and relieve cough, targeting the symptoms of phlegm turbidity blocking the lungs in the hypoxic environment of the plateau; Patchouli and Poria are used to strengthen the spleen and eliminate dampness, and Phragmites australis and Winter Melon Seeds are used to clear heat and penetrate dampness, so as to resolve the disadvantages of dampness and turbidity blocking the spleen in the plateau; Chuanxiong promotes blood circulation and qi circulation, Magnolia officinalis clears the orifices and benefits the nose, and Loquat leaf clears the lungs and relieves cough, which together achieves the effect of treating both the exterior and the interior and regulating the three burners. Clinical studies have shown that this prescription can significantly inhibit the release of inflammatory factors and reduce airway hyperresponsiveness. It can not only dispel external pathogens, but also resolve phlegm and dampness to promote lung qi, which is consistent with the pathogenic characteristics of plateau "low oxygen, high cold, windy, and heavy humidity". It can be used alone or in combination with Western medicine (such as amoxicillin and acetaminophen) to enhance the efficacy, shorten the course of the disease, and prevent transmission through the synergy of Chinese and Western medicine, fully reflecting the traditional Chinese medicine idea of ​​"preventing changes after the disease is cured and taking both the symptoms and the root cause into consideration".

[0009] Individual Chinese herbal medicine components or combinations of Chinese herbal medicine components have the following effects related to severe cold symptoms in plateau environments:

[0010] 1) Open and close exorcism group (for plateau wind, cold, dampness and toxins)

[0011] Fangfeng: dispel wind, relieve exterior symptoms, eliminate dampness and relieve pain → break the biting wind and cold on the plateau; dispel wind, relieve exterior symptoms, eliminate dampness and relieve pain.

[0012] Perilla leaf: dispels cold, promotes qi and blood circulation → opens the Xuanfu to expel evil; treats wind-cold, aversion to cold and fever, headache without sweating, cough and asthma.

[0013] Asarum: warms the meridians and dispels cold, opens the orifices and relieves pain → enters the Shaoyin meridian to expel deep-lying cold pathogens; relieves fever, relieves pain, and is anti-inflammatory.

[0014] Chuanxiong: goes up to the head, goes down to the sea of ​​blood → breaks up plateau blood stasis; promotes blood circulation and qi, dispels wind and relieves pain, and has antibacterial and anti-inflammatory effects.

[0015] 2) Di Tan Tong Qiao Group (for plateau phlegm congestion syndrome)

[0016] Winter melon seeds: clear the lungs and discharge pus, eliminate phlegm and dampness → relieve the thick phlegm and heat on the plateau; clear the lungs and resolve phlegm, relieve pain and discharge pus, and promote dampness.

[0017] Fritillaria thunbergii: clearing heat and dissipating binds, resolving phlegm and relieving cough → resolving the binding of phlegm-heat

[0018] Loquat Leaf: clearing the lung and descending adverse qi, regulating the stomach and resolving phlegm → descending the adverse qi of the lung and stomach; relieving cough, resolving phlegm, relieving asthma, antibacterial

[0019] Magnolia Flower Bud: aromatically unblocking orifices, dispelling wind and benefiting the nose → opening the blocked nasal orifices on the plateau; dispersing wind-cold, unblocking nasal orifices, anti-inflammatory, anti-allergic

[0020] 3) The group for dispersing and descending lung qi (reconstructing the ascending and descending of qi mechanism)

[0021] Apricot Kernel: bitterly descending lung qi, moistening the intestines and relaxing the bowels → descending the turbid qi in the lung; relieving cough and asthma by descending qi, moistening the intestines and relaxing the bowels, anti-inflammatory and analgesic

[0022] Platycodon Root: carrying herbs like a boat, dispersing the lung qi and discharging pus → lifting the clear qi in the lung; clearing the throat and relieving sore throat, resolving phlegm and relieving cough

[0023] Peucedanum Root: resolving phlegm and descending qi, dispersing wind and clearing heat → regulating the lung collaterals; descending qi and resolving phlegm, dispersing wind and clearing heat

[0024] Reed Rhizome: clearing heat and promoting fluid production, expelling pathogenic factors outward → preventing dryness transformation on the plateau; clearing heat and promoting fluid production, stopping vomiting and promoting urination

[0025] 4) The group for promoting the function of the spleen and resolving dampness (aiming at dampness obstruction on the plateau)

[0026] Agastache: awakening the spleen and resolving dampness, dispelling foulness and regulating the middle energizer → resolving the foulness on the plateau; resolving dampness, stopping vomiting, relieving summerheat

[0027] Poria: strengthening the spleen and promoting diuresis, calming the mind and tranquilizing the spirit → strengthening the dike of the middle jiao; promoting diuresis and percolating dampness, strengthening the spleen and tonifying the middle, calming the mind and tranquilizing the spirit

[0028] 5) Compatibility with special effects on the plateau

[0029] Saposhnikovia Root - Asarum - Chuanxiong Rhizome: forming a trend of "penetrating three channels simultaneously", aiming at the three pathogenic factors of "wind, cold, and stasis" on the plateau.

[0030] Winter Melon Seeds - Fritillaria thunbergii - Reed Rhizome: constructing an outlet for phlegm-dampness of "clearing - resolving - promoting diuresis", conforming to the characteristics of viscous phlegm on the plateau.

[0031] Agastache - Poria - Apricot Kernel: achieving the separate elimination of the upper, middle, and lower energizers, dealing with the diffusion of damp-turbidity on the plateau.

[0032] Preferably, it contains 20 g of winter melon seeds, 10 g of saposhnikovia root, 10 g of loquat leaf, 10 g of perilla leaf, 2 g of asarum, 10 g of apricot kernel, 10 g of platycodon root, 5 g of peucedanum root, 15 g of agastache, 15 g of poria, 10 g of magnolia flower bud, 20 g of reed rhizome, 10 g of chuanxiong rhizome, 5 g of fritillaria thunbergii.

[0033] A method for preparing a traditional Chinese medicine composition for treating severe colds on the plateau, comprising the following steps:

[0034] Step A: Prepare various raw materials according to the ratio, and ensure that the quality of the raw materials meets the standards of the Chinese Pharmacopoeia;

[0035] Step B: Prepare the prepared raw materials into decoction-free granules through processes such as extraction, concentration, drying, and granulation.

[0036] Application of a traditional Chinese medicine composition in the treatment of severe colds at high altitudes. The decoction-free granules of the traditional Chinese medicine composition can be used for the treatment of severe colds at high altitudes by oral administration.

[0037] In summary, due to the adoption of the above technical solutions, the beneficial treatment effects of the present invention are:

[0038] When treating severe colds at high altitudes, it has the advantages of more significant curative effects and shorter treatment time, and can effectively avoid the drug resistance and adverse drug reactions that may be caused by western medicines. It has a significant effect in improving the physical fitness of patients, relieving clinical symptoms and reducing the recurrence rate. Conventional anti-cold drugs such as compound codeine phosphate solution, ambroxol oral liquid, paracetamol and caffeine tablets, cefradine capsules, azithromycin dispersible tablets, montelukast sodium tablets, etc. usually take at least 1 week to relieve symptoms, and a small number of patients even need 2 - 3 weeks. About 10% of the patients need to be treated by intravenous infusion to recover, and the clinical curative effects are often not satisfactory. Different from the concept of western medicine mainly focusing on symptomatic treatment, traditional Chinese medicine always follows the principle of syndrome differentiation and treatment when treating colds in high-altitude areas. Traditional Chinese medicine treatment not only focuses on expelling external pathogens, but also emphasizes strengthening the healthy qi of the body through strengthening the healthy qi and consolidating the root, so as to enhance the body's own disease resistance and achieve the treatment effect of treating both the symptoms and the root causes. This treatment concept centered on overall regulation shows unique advantages in the treatment of colds in high-altitude areas, especially in improving the physical fitness of patients, relieving clinical symptoms and reducing the recurrence rate of diseases.

[0039] Due to the special environmental characteristics in plateau areas, such as thin air, low oxygen partial pressure, cold and changeable climate, and large temperature difference between day and night, it has a significant impact on the human body's physiological functions, leading to a decline in the body's resistance. In this environment, cold viruses are more likely to invade the human body than in plain areas, causing cold symptoms and being difficult to cure. There are significant differences between colds in plateau areas and those in plain areas, and its characteristics include a dry tongue image but slightly moist on the surface. Colds in plateau areas have a higher incidence rate in winter and spring, with relatively severe clinical symptoms. Some patients show symptoms such as high fever, coughing yellow phlegm, and running purulent nasal discharge, and the treatment is more difficult. The traditional Chinese medicine composition for treating severe colds in plateau areas provided by the present invention mainly acts on the pathogenesis characteristics of qi stagnation and closure in the lungs. The state of qi stagnation and closure in the lungs can be understood as airway obstruction and decreased lung function caused by inflammatory reactions in the respiratory mucosa, which is related to bronchospasm and the release of inflammatory factors in modern medicine. This formula targets the pathogenesis characteristics of qi stagnation and closure in the lungs, combines the core traditional Chinese medicine theories such as zang-fu organs, meridians and collaterals, qi, blood and body fluids, and etiology and pathogenesis, and takes the treatment principles of dispersing lung qi, resolving phlegm and relieving cough, expelling wind and dispelling cold, dredging collaterals and removing stasis. The compatibility of the drugs in the formula strictly follows the method of monarch, minister, assistant and envoy. By regulating yin and yang, dredging meridians and collaterals, and regulating qi and blood, the lung qi can be dispersed, phlegm turbidity can be resolved, and exogenous pathogens can be dispelled, so as to restore the normal physiological functions of the lungs. Compared with Western medicine treatment, this formula not only focuses on eliminating pathogenic factors, but also emphasizes strengthening healthy qi. Through overall regulation and treating both the symptoms and the root causes, it improves the state of deficiency of healthy qi in patients and enhances the body's disease resistance ability, fully reflecting the core concepts of "preventive treatment of disease" and "treating both the symptoms and the root causes" in traditional Chinese medicine, and having important clinical application value and promotion significance. Detailed implementation manners

[0040] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the present application will be clearly and completely described below in conjunction with the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments.

[0041] Embodiment

[0042] A traditional Chinese medicine composition for treating severe colds in a plateau environment is composed of raw medicinal materials with the following content ratios: 20 g of winter melon seeds, 10 g of ledebouriella root, 10 g of eriobotrya japonica leaves, 10 g of perilla leaves, 2 g of asarum, 10 g of apricot kernels, 10 g of platycodon grandiflorum, 5 g of peucedanum praeruptorum, 15 g of pogostemon cablin, 15 g of poria cocos, 10 g of magnolia liliflora, 20 g of phragmites communis rhizome, 10 g of ligusticum wallichii, and 5 g of fritillaria thunbergii.

[0043] The weight of the raw medicinal materials is 152 g, and after being prepared into decoction-free granules according to national standards, it is 30 g. Patients take it 3 times a day, 10 g each time.

[0044] Animal experiment

[0045] 85 8-week-old BALB / c mice (purchased from Sichuan Dashuo Company), with an average weight of (25±2) g, were raised at a temperature of (20±2)°C and a humidity of (40±5)%, and the animal illumination was 15 - 20 lx. The day-night light-dark cycle was generally 12 - 14 hours during the day and 12 - 10 hours at night. Under these conditions, they were randomly divided into a normal control treatment group, a cold model group, a complete formula group of traditional Chinese medicine composition (A), a group lacking Benincasa hispida in the traditional Chinese medicine composition (B), a group lacking Saposhnikovia divaricata in the traditional Chinese medicine composition (C), a group lacking Eriobotrya japonica in the traditional Chinese medicine composition (D), a group lacking Perilla frutescens in the traditional Chinese medicine composition (E), a group lacking Asarum sieboldii in the traditional Chinese medicine composition (F), a group lacking Prunus armeniaca in the traditional Chinese medicine composition (G), a group lacking Platycodon grandiflorum in the traditional Chinese medicine composition (H), a group lacking Peucedanum praeruptorum in the traditional Chinese medicine composition (I), a group lacking Pogostemon cablin in the traditional Chinese medicine composition (J), a group lacking Poria cocos in the traditional Chinese medicine composition (K), a group lacking Magnolia liliflora in the traditional Chinese medicine composition (L), a group lacking Phragmites australis in the traditional Chinese medicine composition (M), a group lacking Ligusticum chuanxiong in the traditional Chinese medicine composition (N), and a group lacking Fritillaria thunbergii in the traditional Chinese medicine composition (O), with 5 mice in each group.

[0046] Table 1. Grouping of mouse experiments

[0047]

[0048]

[0049] Pharmacodynamic comparative experimental studies were conducted on the traditional Chinese medicine compositions A - O prepared in the above Examples 1 - 15. The specific methods were as follows: Except for the normal control treatment group, the other groups used a low-pressure and hypoxic animal experimental chamber (set with an oxygen concentration of 10.5% and a pressure of 54 kPa) to simulate the plateau environment. The settings were: altitude of 5000 m (10.5%), temperature (20±2)°C, and humidity (40±5%) for continuous exposure for 72 hours. After 24 hours of low-pressure exposure, the Puerto Rico / 8 virus strain at 1×10^5 PFU / 20 μl (intranasal inoculation) and 0.5 μg LPS were used for co-stimulation. Cold stimulation at 4°C (2 hours per day), exercise load: forced swimming to exhaustion (once a day), nutritional intervention: protein-restricted feed (10% protein content), and the mice were allowed to freely eat and drink at other times. The model was established by continuously exposing the mice to the low-pressure and hypoxic environment for 3 days. The mice showed behavioral changes such as curling up, running nose, aversion to cold (manifested as liking to huddle together, defined as the time when the mice huddled together exceeding 10 minutes), and reduced activity, replicating a severe cold mouse model under the plateau environment. The evaluation criteria for a successful model were physiological indicators: blood oxygen saturation: <70%, weight loss: >25%; 2. Behavior: obvious curling up, reduction in activity volume >60%; 3. Pathology: extensive pulmonary edema, TNF-α ≥ 500 pg / ml in BALF, blood lactate ≥ 5 mmol / L.

[0050] From the fifth day, the mice were placed in a normal temperature environment for drug administration and subsequent operations; the normal control treatment group was raised without any treatment for 7 days. From the 5th day of model establishment, the drug group was given intragastric administration for 3 days, and the normal group and the model group were given an equal amount of normal saline by gavage. During this period, the body weights of the animals in each group were recorded. On the 8th day, blood was taken from the eyeballs of the mice in each group. After dissection, the organs were washed with 0.9% sodium chloride solution to remove the blood stains on the surface, and after removing the fascia on the surface of the organs, the water was blotted dry with absorbent paper and then weighed. The lung index was calculated (lung index (%) = wet lung weight / body weight * 100%). The levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in the right lung tissue homogenate were detected by ELISA. Blood samples were collected using EDTA anticoagulant tubes for routine blood tests (including white blood cell count, red blood cell count, platelet count, etc.).

[0051] Results of the pharmacodynamic study of animal experiments:

[0052] (1) Effects of changes in individual components of the traditional Chinese medicine treatment formula on the body weight of mice

[0053] The effects of changes in individual components of the traditional Chinese medicine treatment formula on the body weight of mice are shown in Table 2: Compared with the normal control treatment group, the body weights of the mice in the model group continued to decrease on the 5th and 8th days, and the differences were statistically significant (P < 0.05); compared with the cold model group, the difference in the body weight of the mice in the complete formula group (A) of the traditional Chinese medicine composition was statistically significant on the 8th day (P < 0.05). The body weights of the mice in the traditional Chinese medicine composition (C) without Saposhnikoviae Radix, the traditional Chinese medicine composition (D) without Eriobotryae Folium, the traditional Chinese medicine composition (E) without Perillae Folium, the traditional Chinese medicine composition (I) without Peucedani Radix, and the traditional Chinese medicine composition (O) without Fritillaria thunbergii Miq. continued to decrease, and the differences were statistically significant compared with the complete formula group (A) on the 8th day (P < 0.05). The body weights of the mice in the traditional Chinese medicine composition (B) without Benincasae Semen, the traditional Chinese medicine composition (F) without Asari Radix et Rhizoma, the traditional Chinese medicine composition (M) without Phragmitis Rhizoma, the traditional Chinese medicine composition (N) without Chuanxiong Rhizoma, the traditional Chinese medicine composition (G) without Armeniacae Semen Amarum, and the traditional Chinese medicine composition (H) without Platycodonis Radix tended to be stable on the 8th day, and the differences were statistically significant compared with the complete formula group (A) (P < 0.05). The body weights of the mice in the traditional Chinese medicine composition (J) without Pogostemonis Herba, the traditional Chinese medicine composition (K) without Poria, and the traditional Chinese medicine composition (L) without Magnoliae Flos increased on the 8th day, but the increase was smaller than that of the complete formula group (A), and the difference was not statistically significant compared with the complete formula group (A) (P > 0.05).

[0054] Table 2. Effects of changes in individual components of the traditional Chinese medicine treatment formula on the body weight of mice

[0055]

[0056] Note: Compared with the normal control treatment group, aP < 0.05; compared with the model group, b P < 0.05; compared with the complete formula group, c P < 0.05

[0057] (2) Effects of changes in individual components of the traditional Chinese medicine treatment formula on the lung weight and lung index of mice

[0058] The effects of changes in individual components of the traditional Chinese medicine treatment formula on the lung weight and lung index of mice are shown in Table 3: Compared with the normal control treatment group, the lung weight and lung index of mice in the cold model group increased, and the difference was statistically significant (P < 0.05); the lung weight and lung index of mice in the complete formula group (A) of the traditional Chinese medicine composition returned to the level of the normal control treatment group, and the difference was statistically significant compared with the model group (P < 0.05). The lung weight and lung index of mice in the traditional Chinese medicine composition (C) without Saposhnikoviae Radix, the traditional Chinese medicine composition (D) without Eriobotryae Folium, the traditional Chinese medicine composition (E) without Perillae Folium, the traditional Chinese medicine composition (I) without Peucedani Radix, and the traditional Chinese medicine composition (O) without Fritillaria thunbergii Miq. continued to increase, and the difference was statistically significant compared with the complete formula group (A) (P < 0.05). The growth of the lung weight and lung index of mice in the traditional Chinese medicine composition (B) without Benincasae Semen, the traditional Chinese medicine composition (F) without Asari Radix et Rhizoma, the traditional Chinese medicine composition (M) without Phragmitis Rhizoma, the traditional Chinese medicine composition (N) without Chuanxiong Rhizoma, the traditional Chinese medicine composition (G) without Armeniacae Semen Amarum, and the traditional Chinese medicine composition (H) without Platycodonis Radix tended to be stable, and the difference was statistically significant compared with the complete formula group (A) (P < 0.05). The lung weight and lung index of mice in the traditional Chinese medicine composition (J) without Pogostemonis Herba, the traditional Chinese medicine composition (K) without Poria, and the traditional Chinese medicine composition (L) without Magnoliae Flos decreased to some extent, but the decrease was smaller than that of the complete formula group (A), and the difference was not statistically significant compared with the complete formula group (P > 0.05).

[0059] Table 3. Effects of changes in individual components of the traditional Chinese medicine treatment formula on the lung weight and lung index of mice

[0060] Group Lung weight (g) Lung index Normal control treatment group 0.16±0.015 0.59±0.06 Cold model group <![CDATA[0.24±0.013 a > <![CDATA[1.15±0.04 a > Group A <![CDATA[0.15±0.008 b > <![CDATA[0.66±0.04 b > Group B <![CDATA[0.18±0.01 c > <![CDATA[0.84±0.05 c > Group C <![CDATA[0.24±0.01 c > <![CDATA[1.13±0.06 c > Group D <![CDATA[0.23±0.016 c > <![CDATA[1.1±0.78 c > Group E <![CDATA[0.21±0.015 c > <![CDATA[0.98±0.09 c > Group F <![CDATA[0.17±0.15 c > <![CDATA[0.82±0.07 c > Group G <![CDATA[0.18±0.016 c > <![CDATA[0.86±0.07 c > Group H <![CDATA[0.17±0.01 c > <![CDATA[0.79±0.06 c > Group I <![CDATA[0.21±0.015 c > <![CDATA[1.01±0.04 c > Group J 0.16±0.014 0.68±0.05 Group K 0.17±0.03 0.76±0.12 Group L 0.15±0.01 0.65±0.03 Group M <![CDATA[0.18±0.016 c > <![CDATA[0.87±0.07 c > Group N <![CDATA[0.19±0.013 c > <![CDATA[0.94±0.05 c > Group O <![CDATA[0.21±0.008 c > <![CDATA[1.02±0.04 c >

[0061] Note: Compared with the normal control treatment group, a P < 0.05; compared with the model group, b P < 0.05; compared with the complete formula group, c P < 0.05

[0062] (3) Effects of changes in individual components of the traditional Chinese medicine treatment formula on the levels of TNF-α and IL-6 in the serum of mice

[0063] The effects of the change of individual components of the traditional Chinese medicine treatment formula on the levels of TNF-α and IL-6 in the serum of mice are shown in Table 4: Compared with the normal control treatment group, the levels of TNF-α and IL-6 in the serum of the cold model group mice increased, and the difference was statistically significant (P < 0.05); the levels of TNF-α and IL-6 in the serum of the mice in the complete formula group (A) of the traditional Chinese medicine composition were close to those of the normal control treatment group, and the difference was statistically significant compared with the model group (P < 0.05). The levels of TNF-α and IL-6 in the serum of the mice in the traditional Chinese medicine composition (C) without Saposhnikovia divaricata, the traditional Chinese medicine composition (D) without Eriobotrya japonica, the traditional Chinese medicine composition (E) without Perilla frutescens, the traditional Chinese medicine composition (I) without Peucedanum praeruptorum, and the traditional Chinese medicine composition (O) without Fritillaria thunbergii continued to increase, and the difference was statistically significant compared with the complete formula group (A) (P < 0.05). The levels of TNF-α and IL-6 in the serum of the mice in the traditional Chinese medicine composition (B) without Benincasa hispida var. chieh-qua, the traditional Chinese medicine composition (F) without Asarum sieboldii, the traditional Chinese medicine composition (M) without Phragmites australis, the traditional Chinese medicine composition (N) without Ligusticum chuanxiong, the traditional Chinese medicine composition (G) without Armeniaca vulgaris, and the traditional Chinese medicine composition (H) without Platycodon grandiflorum tended to be stable, and the difference was statistically significant compared with the complete formula group (A) (P < 0.05). The levels of TNF-α and IL-6 in the serum of the mice in the traditional Chinese medicine composition (J) without Pogostemon cablin, the traditional Chinese medicine composition (K) without Poria cocos, and the traditional Chinese medicine composition (L) without Magnolia liliflora decreased to some extent, but the decrease range was smaller than that of the complete formula group (A), and the difference was not statistically significant compared with the complete formula group (P > 0.05).

[0064] Table 4. Effects of the change of individual components of the traditional Chinese medicine treatment formula on serum TNF-α and IL-6

[0065] Group TNF-α (pg / mL) IL-6 (pg / mL) Normal control treatment group 10.92±0.92 15.66±0.32 Model group <![CDATA[27.28+0.76 a > <![CDATA[36.64±0.45 a > Group A <![CDATA[11.28±0.28 b > <![CDATA[15.78±0.76 b > Group B <![CDATA[19.68±1.03 c > <![CDATA[25.34±0.46 c > Group C <![CDATA[24.62±1.48 c > <![CDATA[35.18±0.7 c > Group D <![CDATA[25.34±1.15 c > <![CDATA[36.56±1.14 c > Group E <![CDATA[26.5±1.55 c > <![CDATA[34.8±3.82 c > Group F <![CDATA[15.18±1.33 c > <![CDATA[20.78±3.98 c > Group G <![CDATA[16.22±1.65 c > <![CDATA[24.06±1.58 c > Group H <![CDATA[16.6±1.03 c > <![CDATA[24.04±2.62 c > Group I <![CDATA[25.86±1.77 c > <![CDATA[35.5±2.35 c > Group J 13.04±1.89 17.72±1.96 Group K 12.38±1.05 16.98±2.02 Group L 11.58±0.91 16.5±1.54 Group M <![CDATA[16.44±0.89 c > <![CDATA[25.08±2.84 c > Group N <![CDATA[15.16±1.21 c > <![CDATA[26.68±1.55 c > Group O <![CDATA[21.66±1.05 c > <![CDATA[34.34±4.57 c >

[0066] Note: Compared with the normal control treatment group, a P < 0.05; compared with the model group, b P < 0.05; compared with the complete formula group, c P < 0.05. It can be seen from Tables 1 - 4 that:

[0067] In the traditional Chinese medicine composition treatment formula for severe cold, each component plays a synergistic therapeutic role and jointly constructs a multi-level and multi-target therapeutic system. Among them, the components such as Saposhnikovia divaricata, Perilla frutescens, Peucedanum praeruptorum, Fritillaria thunbergii, and Eriobotrya japonica play particularly significant roles. They are in the core position and are the key to the treatment of severe cold. If these components are missing, it will not only affect the overall efficacy of the prescription, but may also lead to significant changes in indicators such as body weight, lung weight, lung index, TNF-α, and IL-6, reflecting the imbalance of the body in inflammatory response and immune regulation.

[0068] From the perspective of traditional Chinese medicine theory, Fangfeng (Ledebouriella seseloides) is pungent and warm in nature, and belongs to the bladder, liver, and spleen meridians. It has the effects of expelling wind and relieving exterior syndrome, and treating pain caused by dampness. It is the monarch drug for the main syndrome of exogenous wind-cold attacking the body surface and disharmony between the defensive qi and the nutritive qi. It can disperse exogenous pathogenic factors, regulate the defensive qi, make the pores unobstructed, and the pathogenic factors be resolved with sweating. Zisuye (Perilla frutescens) is pungent and warm in nature, and belongs to the lung and spleen meridians. It can relieve exterior syndrome and dispel cold, regulate qi and harmonize the middle-jiao. It is applicable to wind-cold cold, cough, vomiting, etc. Its function of regulating qi and harmonizing the middle-jiao can also relieve qi stagnation in the spleen and stomach and regulate the qi movement in the middle-jiao. Qianhu (Peucedanum praeruptorum) is pungent and cool in nature, and belongs to the lung meridian. It can clear heat and detoxify, and disperse the lung qi and resolve phlegm. As the minister drug to assist the monarch drug, it is used for the concurrent syndrome of wind-cold cold with phlegm-heat, clearing away the heat in the lung and resolving phlegm and relieving cough. Zhebeimu (Fritillaria thunbergii) is bitter and cold in nature, and belongs to the lung and heart meridians. It has the effects of clearing heat and dissipating binds, and resolving phlegm and relieving cough. It is an important minister drug for treating phlegm-heat cough, which can clear away the heat in the lung, soften hardness and dissipate binds, so that phlegm-heat can be cleared and the lung qi can descend. Pipaye (Eriobotrya japonica) is neutral in nature and bitter in taste, and belongs to the lung and stomach meridians. Its main effects are clearing the lung and relieving cough, promoting diuresis with the stomach, and suppressing the adverse rising qi and stopping vomiting. It is used to assist the monarch drug in treating symptoms such as cough due to heat in the lung, dyspnea with rapid respiration, etc. Its function of suppressing the adverse rising qi and stopping vomiting can also relieve nausea and vomiting caused by the adverse rising of lung qi and stomach qi.

[0069] In addition, although components such as Asarum sieboldii, Ligusticum chuanxiong, Poria cocos, Phragmites australis, Prunus armeniaca, Platycodon grandiflorum, Pogostemon cablin, Magnolia biondii, Benincasa hispida var. chieh-qua, etc. are slightly lower in status in the formula than the above core components, they also play an irreplaceable role. Asarum sieboldii is pungent and warm in nature, and belongs to the lung and kidney meridians. It has the effects of dispelling wind and cold, and dredging the orifices to relieve pain. It can relieve concurrent symptoms such as nasal congestion and headache, and at the same time guide the medicine upward to reach the affected area directly. Ligusticum chuanxiong is pungent and warm in nature, and belongs to the liver, gallbladder, and pericardium meridians. It promotes blood circulation and qi movement, dispels wind and relieves pain. It can relieve discomfort such as headache and chest tightness caused by qi stagnation and blood stasis, and also enhance the blood-activating and collaterals-dredging effect of the formula. Poria cocos is sweet and flat in nature, and belongs to the heart, lung, spleen, and kidney meridians. It strengthens the spleen and promotes diuresis, calms the mind and soothes the nerves. By regulating the spleen and stomach, it enhances the vital qi of the body, and is a harmonizing agent among the assistant drugs, enabling the formula to strengthen the healthy qi while dispelling pathogenic factors. Phragmites australis is sweet and cold in nature, and belongs to the lung and stomach meridians. It clears heat and promotes fluid production, eliminates vexation and stops vomiting. It can regulate the stomach qi, relieve vomiting and nausea, and at the same time clear and drain the lung heat, promote fluid production and quench thirst. Prunus armeniaca is bitter and warm in nature, and belongs to the lung and large intestine meridians. It lowers qi to relieve cough and asthma, and loosens the bowels to relieve constipation. Its effect of lowering qi and relieving cough synergizes with Fritillaria thunbergii var. chekiangensis to enhance the cough-relieving and asthma-suppressing efficacy of the formula. Platycodon grandiflorum is bitter, pungent and flat in nature, and belongs to the lung meridian. It disperses the lung qi, eliminates phlegm, and promotes the discharge of pus by relieving sore throat. It is one of the guiding drugs in the formula, capable of dispersing the lung qi, eliminating phlegm and relieving cough, and promoting the discharge of pus by relieving sore throat. Pogostemon cablin is pungent and warm in nature, and belongs to the spleen, stomach, and lung meridians. It relieves the exterior syndrome and resolves dampness, regulates qi and harmonizes the middle-jiao. It can regulate the spleen and stomach, relieve the exterior syndrome and resolve dampness, and guide the medicine into the middle-jiao, enabling the formula to take into account the spleen and stomach while treating lung diseases. Magnolia biondii is pungent and warm in nature, and belongs to the lung and stomach meridians. It dispels wind and cold, dredges the orifices, and guides the medicine to reach the head and face, relieving upper respiratory tract symptoms such as nasal congestion and headache. Benincasa hispida var. chieh-qua is cool in nature and sweet in taste, and belongs to the lung and large intestine meridians. It moistens the lung and resolves phlegm, promotes diuresis and reduces swelling. It can assist Fritillaria thunbergii var. chekiangensis in resolving phlegm and relieving cough, and at the same time promotes diuresis and reduces swelling, improving the body's water metabolism. Although these components are slightly lower in status in the formula, through functions such as regulating the spleen and stomach, enhancing the vital qi of the body, dispersing the lung qi, eliminating phlegm, promoting the discharge of pus by relieving sore throat, relieving the exterior syndrome and resolving dampness, regulating qi and harmonizing the middle-jiao, and guiding the medicine into the middle-jiao, they jointly construct a complete treatment system, enabling the formula to take into account both the symptoms and the root cause when treating severe colds, dispelling pathogenic factors without harming the healthy qi, strengthening the healthy qi without leaving pathogenic factors behind, and achieving the treatment purpose of regulating yin and yang and restoring the body balance. Therefore, the absence of these components will also have a certain impact on indicators such as body weight, lung weight, lung index, TNF-α, and IL-6, reflecting the imbalance of the body in terms of inflammatory response, immune regulation, and zang-fu organ functions.

[0070] Clinical trial

[0071] The traditional Chinese medicine composition for treating severe altitude cold described in Example 1 was used for clinical trials. The following are the process and test result data of the clinical trials:

[0072] 1. Experimental subjects:

[0073] A total of 174 patients were included in this trial. The patients had lived in the plateau area (areas above 4000 meters above sea level in Litang and Batang areas, Sichuan Province) for 3 months or more. Among them, there were 114 males and 60 females. The age range of the patients was 18 - 66 years old, and the average age was 41.53 ± 8.96 years.

[0074] 2. Inclusion criteria:

[0075] 1) Meeting the diagnostic criteria: According to the severe cold diagnostic criteria in the "Expert Consensus on the Standard Diagnosis and Treatment of Common Cold" promulgated by the Chinese Medical Doctor Association;

[0076] 2) Age ≥ 18 years old;

[0077] 3) The time from the onset of cold symptoms to seeking medical treatment ≤ 48 hours.

[0078] 3. Exclusion criteria:

[0079] 1) Complicated with pneumonia, bronchitis, otitis media, angina, viral myocarditis, acute nephritis, rheumatic arthritis, etc.;

[0080] 2) Complicated with hepatic and renal insufficiency;

[0081] 3) Having a clear history of allergy to the drug components of antiviral oral liquid;

[0082] 4) Pregnant or lactating women;

[0083] 5) Suspected severe or critical influenza patients;

[0084] 6) Diarrhea due to spleen and stomach deficiency and cold;

[0085] 7) Unable to cooperate with the completion of clinical observation due to intellectual or behavioral disorders;

[0086] 8) Currently participating or having participated in other clinical studies of cold drugs within 1 month before treatment;

[0087] 9) Taking other cold prevention and treatment drugs within 48 hours before enrollment.

[0088] 10) Other patients who are judged by the researcher as not suitable to participate in this study.

[0089] 4. Experimental methods:

[0090] The patients seeking medical treatment are randomly divided into a general treatment group, a combined treatment group, and a control treatment group. Among them, the control treatment group uses western medicine alone for treatment, the general treatment group uses traditional Chinese medicine for treatment, and the combined treatment group uses a combination of traditional Chinese and western medicine for treatment. There are 16 people in the general experimental group, 48 people in the combined treatment experimental group, and 22 people in the control treatment group. Among them, there are 14 males and 8 females in the control treatment group; 9 males and 7 females in the general experimental group; 29 males and 19 females in the combined treatment group;

[0091] The Western medicines used in the control treatment group can be: paracetamol, caffeine and chlorpheniramine maleate capsules (produced by Baiyunshan Tangyin Dongtai Pharmaceutical Co., Ltd., taken 3 times a day, 2 capsules each time), ambroxol oral liquid (produced by Yangzhou Sanyao Pharmaceutical Co., Ltd., taken 3 times a day, 10 mL each time), cefradine capsules (produced by Shandong Lukang Pharmaceutical Co., Ltd., taken 3 times a day, 2 capsules each time), azithromycin dispersible tablets (produced by Shijiazhuang Pharmaceutical Group, taken once a day, 2 tablets each time). One or more of the above Western medicines can be selected according to the different conditions of different patients.

[0092] The traditional Chinese medicine composition of the oral administration example in the general treatment group: The traditional Chinese medicine treatment formula is taken 3 times a day by brewing with boiling water, and 10 grams of traditional Chinese medicine instant granules (produced by Yifang Pharmaceutical Co., Ltd.) each time.

[0093] The combined treatment group conducts the combined treatment of the traditional Chinese medicine treatment formula + Western medicine in the example: On the basis of the traditional Chinese medicine treatment formula in the example, one or several of paracetamol, caffeine and chlorpheniramine maleate capsules, ambroxol oral liquid, cephalosporin tablets, and azithromycin dispersible tablets are added according to the actual situation (selected as needed according to the different conditions of different patients).

[0094] 5. Observation indicators:

[0095] The subjective feelings of patients on the curative effect of the traditional Chinese medicine treatment formula. Compared with the previous Western medicine treatment of severe colds on the plateau, the subjective feelings of patients on the curative effect of the traditional Chinese medicine treatment formula or the combined treatment of the traditional Chinese medicine treatment formula + Western medicine: "better", "equivalent" or "worse".

[0096] The number of days for complete symptom remission. Starting from the start of medication, the number of days required for all major symptoms (such as fever, cough, nasal congestion, etc.) to completely disappear.

[0097] 6. Efficacy evaluation:

[0098] Cured: After 3 days of treatment, symptoms, signs, laboratory tests (such as white blood cell count, C-reactive protein level, etc.) and professional specific indicators all return to normal;

[0099] Markedly effective: After 3 days of treatment, one of the above four aspects (one of symptoms, signs, laboratory tests and professional specific indicators) does not return to normal;

[0100] Effective: After 3 days of treatment, two of the above four aspects (two of symptoms, signs, laboratory tests and professional specific indicators) do not return to normal;

[0101] Ineffective: No change or deterioration after 3 days of treatment.

[0102] Effective rate: (Number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0103] Adverse drug reactions. Whether there are adverse drug reactions, such as mild dizziness, fatigue, nausea, upper abdominal discomfort, loss of appetite, vomiting, diarrhea, abdominal pain, etc.

[0104] 7. Treatment Results

[0105] (1) Subjective Evaluation

[0106] The subjective evaluations of the patients on the treatment effects are shown in Table 5. The subjective feedback of the patients on the treatment effects was collected through a questionnaire survey. The questionnaire content included aspects such as treatment effects, symptom remission time, and adverse reactions. Among the patients in the conventional treatment group, 62.5% of the patients believed that the traditional Chinese medicine treatment plan was superior to western medicine in the treatment of severe colds, 12.5% of the patients believed that the treatment effects of traditional Chinese medicine and western medicine were equivalent, and 25.0% of the patients believed that the effect of the traditional Chinese medicine treatment plan was inferior to western medicine. Among the patients in the combined treatment group, 83.4% of the patients believed that the combined treatment of traditional Chinese medicine and western medicine was superior to the use of western medicine alone in severe colds. The chi-square test was used to compare the differences between groups, and the results showed that the differences were statistically significant (P < 0.05, n = 50). 8.3% of the patients believed that the combined treatment of traditional Chinese medicine and western medicine was equivalent to the use of western medicine alone, and 8.3% of the patients believed that the effect of the combined treatment of traditional Chinese medicine and western medicine was inferior to the use of western medicine alone.

[0107] Table 5. Subjective Evaluation of the Efficacy of Traditional Chinese Medicine or the Combined Treatment of Traditional Chinese Medicine and Western Medicine in Patients with Severe Colds

[0108]

[0109] (2) Number of Days to Complete Remission after Treatment

[0110] As shown in Table 6, the remission times of symptoms such as cough, expectoration, nasal congestion, rhinorrhea, pharyngeal discomfort, headache, fatigue, etc. in the conventional treatment group and the combined treatment group were significantly shorter than those in the control treatment group, and the differences were statistically significant (P < 0.05). The remission times of expectoration and rhinorrhea symptoms in the combined treatment group were significantly shorter than those in the conventional treatment group, and the differences were statistically significant (P < 0.05). There was no statistically significant difference in the remission times of symptoms such as cough, nasal congestion, pharyngeal discomfort, headache, fatigue, etc. between the conventional treatment group and the combined treatment group (P > 0.05).

[0111] Table 6. Number of Days to Complete Remission of Cold Symptoms after Treatment with Traditional Chinese Medicine, Western Medicine, or the Combined Treatment of Traditional Chinese Medicine and Western Medicine

[0112]

[0113] Data are expressed as mean ± standard deviation; P 1 , conventional treatment group vs. control treatment group; P 2 , combined treatment group vs. control treatment group; P 3 , combined treatment group vs. conventional treatment group

[0114] (3) Comprehensive Evaluation of Efficacy

[0115] As shown in Table 7, after 3 days of treatment, in the control treatment group, 6 cases were effective, 2 cases were markedly effective, 0 cases were cured, and the total effective rate was 36.4% (total effective rate = (number of effective cases + number of markedly effective cases + number of cured cases) / total number of cases × 100%); in the general treatment group, 3 cases were effective, 10 cases were markedly effective, 2 cases were cured, and the total effective rate was 93.8%; in the combined treatment group, 4 cases were effective, 22 cases were markedly effective, 20 cases were cured, and the total effective rate was 95.8%. The total effective rates of the general treatment group and the combined treatment group were both significantly higher than that of the control treatment group, and the difference was statistically significant (P < 0.001).

[0116] Table 7. Comprehensive curative effects of western medicine, traditional Chinese medicine, or combined western and traditional Chinese medicine treatment

[0117]

[0118]

[0119] Total effective rate: (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%. P 总有效率 : general treatment group or combined treatment group vs. control

[0120] treatment group.

[0121] (4) Adverse drug reactions

[0122] As shown in Table 8, 1 case of adverse drug reaction (skin itching) occurred in the control treatment group, 1 case of adverse drug reaction (diarrhea) occurred in the combined treatment group, and no adverse drug reactions were observed in other groups.

[0123] Table 8. Adverse drug reactions

[0124]

[0125] It can be seen from Tables 5 - 8 that:

[0126] Both traditional Chinese medicine treatment prescriptions and the combined treatment of traditional Chinese and Western medicines for severe colds in high altitudes have significant curative effects and few adverse reactions. This prescription contains Chinese medicinal materials such as winter melon seeds, perilla leaves, reed rhizomes, and fritillaria thunbergii. Its mechanism of action in treating severe colds in high altitudes mainly targets the state of qi stagnation and closure in the lungs. In high altitude areas, the climate is cold, and exogenous pathogens are likely to invade the human body, leading to the insecurity of the lung defense, the failure of the lung qi to disperse, and then the syndrome of qi stagnation and closure in the lungs, manifested as symptoms such as cough, asthma, chest tightness, and excessive phlegm. According to classical Chinese medicine theory and modern pharmacological research, winter melon seeds are cold in nature and sweet in taste, and belong to the lung and large intestine meridians. They have the effects of tonifying qi and beautifying the face, eliminating phlegm and relieving vexation, moistening the lungs and relieving cough, and awakening the spleen and promoting appetite. Its efficacy has been preliminarily verified in modern medical research and is widely used in clinical practice. "Compendium of Materia Medica" records that winter melon seeds can "clear away heat and resolve phlegm, promote diuresis and relieve stranguria", and are applicable to various syndromes of phlegm-dampness obstructing the lungs and disharmony between the spleen and stomach. "Chinese Pharmacopoeia" records that perilla leaves are warm in nature and pungent in taste, and belong to the lung and spleen meridians. They can be used for wind-cold colds, cough and nausea, vomiting during pregnancy, and poisoning by fish and crabs. Perilla leaves are pungent, warm, and dispersing, with the functions of relieving exterior syndrome and dispelling cold, regulating qi and harmonizing the middle energizer. They can ventilate the lung qi, regulate the spleen and stomach, so that exogenous pathogens can be resolved and internal qi can flow smoothly. Reed rhizomes are cold in nature and sweet in taste, and belong to the lung and stomach meridians. They have the effects of clearing away heat and promoting fluid production, and relieving vexation and stopping vomiting. In severe colds in high altitude environments, they can clear away the heat in the lungs, promote fluid production and quench thirst, and relieve symptoms such as heat in the lung and stomach, vexation and thirst, and vomiting due to exogenous pathogen invasion. Fritillaria thunbergii is cold in nature and bitter in taste, and belongs to the lung and heart meridians. It has the functions of clearing away heat and dissipating nodules, and resolving phlegm and relieving cough. Its bitter and cold nature can clear away the heat in the lungs, resolve phlegm and dissipate nodules, and is applicable to symptoms such as cough, asthma, and thick yellow phlegm caused by heat-phlegm congesting the lungs. In addition, platycodon grandiflorum is neutral in nature, bitter and pungent in taste, and belongs to the lung meridian. It has the effects of promoting lung qi, resolving phlegm, and relieving sore throat and discharging pus. In the prescription, it can ventilate the lung qi, resolve phlegm and relieve cough, relieve sore throat and discharge pus, so that the lung qi can be ventilated and phlegm-dampness can be discharged, thereby relieving symptoms such as cough, asthma, and sore throat. To sum up, this prescription, through the synergistic effect of various Chinese medicinal materials, dispels pathogenic factors and strengthens the healthy qi, ventilates the lungs and relieves cough, clears away heat and resolves phlegm, and is applicable to the treatment of severe colds in high altitude environments, reflecting the treatment principles of syndrome differentiation and treatment, and treating both the symptoms and the root causes in traditional Chinese medicine.

[0127] The above-described embodiments only represent the specific implementation manners of the present application. Their descriptions are relatively specific and detailed, but they should not be construed as limiting the protection scope of the present application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the technical solution of the present application, several modifications and improvements can still be made, and these all belong to the protection scope of the present application.

Claims

1. A Chinese medicine composition for treating severe plateau cold, characterized in that: The invention is prepared from the following raw materials in parts by weight: 20 parts of wax gourd seeds, 10 parts of siler leaves, 10 parts of loquat leaves, 10 parts of perilla leaves, 2 parts of asarum, 10 parts of apricot kernels, 10 parts of platycodon grandiflorum, 5 parts of peucedanum, 15 parts of patchouli, 15 parts of tuckahoe, 10 parts of magnolia, 20 parts of reed roots, 10 parts of ligusticum chuanxiong and 5 parts of thunbergii bulbs.

2. The Chinese medicine composition for treating severe plateau cold according to claim 1, wherein the dosage of each component is: 20g of wax gourd seeds, 10g of siler, 10g of loquat leaves, 10g of perilla leaves, 2g of asarum, 10g of apricot kernel, 10g of platycodon, 5g of peucedanum, 15g of patchouli, 15g of poria, 10g of magnolia, 20g of reed root, 10g of ligusticum chuanxiong, and 5g of thunbergii bulb.

3. A method for preparing a Chinese medicine composition for treating severe high altitude cold according to any one of claims 1 to 2, comprising the following steps: Step A: preparing various raw materials according to the ratio described in any one of claims 1-2; Step B: Prepare the prepared raw materials into fry-free granules.

4. Use of the Chinese medicine composition according to any one of claims 1 to 2 in treating severe plateau colds, characterized in that: The Chinese medicine composition can be orally used to treat severe colds in plateau environments.

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