Pharmaceutically acceptable salts of substituted tetrahydrofuran derivatives, crystalline forms thereof and uses thereof
By preparing various medicinal salts of compound 1, the problem of its unsatisfactory physicochemical properties was solved, and a more stable and effective analgesic effect was achieved, which is suitable for treating various types of pain such as chronic pain, acute pain, and inflammatory pain.
CN120040431BActive Publication Date: 2026-06-09SHANDONG SUNCADIA MEDICINE CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG SUNCADIA MEDICINE CO LTD
- Filing Date
- 2025-02-21
- Publication Date
- 2026-06-09
AI Technical Summary
Technical Problem
Existing Nav1.8 inhibitors have undesirable defects in terms of drug physicochemical and biological properties, which affects their application in clinical treatment.
Method used
Pharmaceutically usable salts of compounds of Formula 1 were developed, including hydrochloride, sulfate, phosphate, methanesulfonate, p-toluenesulfonate, maleate, fumarate and tartrate, etc., and polymorphs were prepared by different chemical ratios and solvent systems to optimize their physicochemical properties.
Benefits of technology
The stability and pharmaceutical properties of the compound were improved, making it more suitable for industrial production and biological activity. It has analgesic effects and is suitable for treating a variety of pain types.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN120040431B_ABST
Abstract
The present disclosure relates to a pharmaceutically acceptable salt of a substituted tetrahydrofuran derivative, a crystalline form thereof and uses. Specifically, the present disclosure provides a pharmaceutically acceptable salt of (2R, 3S, 4S, 5R)-3-(3, 4-difluoro-2-methoxyphenyl)-N-(2-((Z)-(N'-hydroxymethylcarbamimidoyl)pyridin-4-yl)-4, 5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide, a crystalline form thereof and a preparation method thereof, and the corresponding salt has good stability and can be better used for clinical treatment.
Need to check novelty before this filing date? Find Prior Art