Zebra fish radiation dose estimation method and device based on simplified anatomical model

Abstract

The invention discloses a zebra fish radiation dose estimation method and device based on a simplified anatomical model and a computer readable storage medium containing a program or instruction for executing the zebra fish radiation dose estimation method based on the simplified anatomical model. Compared with an existing design, calculation precision is improved, different from an existing spheroid model, a simplified anatomical model is adopted to distinguish different tissues and organs of the zebra fish, so that the radiation dose can be estimated more accurately, and particularly, the radiation dose is more accurate when radiation sensitive organs are processed. Compared with a complex anatomical model, the simplified anatomical model adopted by the method takes an ellipsoid as a main shape, so that the calculation process is simplified, relatively high calculation precision is ensured, and the method is suitable for practical application. The method is compatible with an existing radiation influence evaluation program, the effectiveness of the method is verified through comparison with a calculation result, and the method has a good application prospect.

Description

Technical Field

[0001] The present invention relates to the field of radiation dose measurement, and particularly to a method, device and computer-readable storage medium for estimating the radiation dose of zebrafish based on a simplified anatomical model. Background Art

[0002] With the increasing global attention to environmental protection and radiation protection, the assessment of the radiation impact on non-human species has become an important topic. The impact of radiation on organisms, especially the long-term effects of low-dose radiation, has always been one of the difficulties in the scientific research field. Organizations such as the International Atomic Energy Agency (IAEA), the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), and the International Commission on Radiological Protection (ICRP) have all carried out relevant research and proposed various radiation dose assessment methods.

[0003] In past assessment methods, the commonly used biological models represented organisms with simple geometric shapes (such as ellipsoids) and assumed uniform density, elemental composition, and radionuclide distribution within the organisms. Although this method is simple in some applications, it has significant defects, mainly reflected in the following aspects:

[0004] Lack of accuracy in the simplified model: Existing assessment methods usually regard organisms as a uniform ellipsoid model, ignoring the differences in internal tissues and organs of the organisms. This makes it impossible to accurately distinguish the radiation absorption and dose effects of different tissues and organs when estimating the radiation dose.

[0005] Deviation in radiation dose estimation: Due to the insufficient consideration of the density, elemental composition, and radionuclide distribution of different tissues and organs of the organisms, the existing calculation results may have deviations, especially the impact assessment of radiation-sensitive organs is insufficient. Such deviations may lead to underestimation or overestimation of the radiation impact, affecting the scientific decision-making of environmental protection.

[0006] Limitations of the radiation model: Existing models (such as the ERICA and RESRAD-BIOTA programs) simplify the treatment of organisms too much, ignoring the specific structures and functional characteristics of various tissues and organs within the organisms. Therefore, they cannot accurately simulate the process of radiation propagation and absorption within the organisms.

[0007] Therefore, how to establish a more accurate radiation dose estimation method, distinguish the structures and functions of different tissues and organs, and provide a model closer to the actual organism has become an urgent problem to be solved in the current technical field. Summary of the Invention

[0008] The object of the present invention is to solve the deficiencies in the prior art, and to provide a method and device for estimating the radiation dose of zebrafish based on a simplified anatomical model, as well as a computer-readable storage medium containing a program or instruction for executing the method for estimating the radiation dose of zebrafish based on the simplified anatomical model.

[0009] To solve the above technical problems, the technical method adopted by the present invention is: the present invention discloses a method for estimating the radiation dose of zebrafish based on a simplified anatomical model, including the following steps: including the following steps:

[0010] S1. Measure the shape parameters and masses of the whole zebrafish, as well as its bones, internal organs, and ovaries.

[0011] S2. Draw a sketch according to the measured parameters of the model organism zebrafish, mark the obtained geometric parameters, and approximate and simplify the shapes of the whole zebrafish, as well as its bones, internal organs, and ovaries using geometric bodies, determine the surface equations of each part and their mutual relationships, and form a simplified anatomical model.

[0012] S3. Based on the simplified anatomical model established in step S2, write the various surfaces and their mutual relationships into the input file format of Monte Carlo simulation software, run the simulation to obtain the model of the model organism zebrafish and the cross-sectional views of different sections, and form a Monte Carlo simplified anatomical model.

[0013] S4. Estimation of the zebrafish dose rate: Using the established Monte Carlo simplified anatomical model, write a source file, run the simulation to obtain the deposited energy of particles with different energies, substitute it into the dose coefficient calculation formula, and calculate the internal and external irradiation dose coefficients of the model organism zebrafish.

[0014] S5. Weight the activity concentrations of each part of the model organism zebrafish according to the mass to obtain the average activity concentration of the organism, and input this concentration and the geometric size into the ERICA program, and run to obtain the dose rate of each part of the organism.

[0015] Further, the surface equation of the whole zebrafish is:

[0016] The surface equation of the zebrafish bone is:

[0017] The surface equation of the zebrafish internal organs is:

[0018] The surface equation of the zebrafish ovary is:

[0019] Further, in step S4, the internal irradiation dose coefficient of the zebrafish is:

[0020]

[0021] The external irradiation dose coefficient of zebrafish is:

[0022] In the formula: 5.76×10-4 is the conversion coefficient from MeV / s to μJ / h; ν is the radiation type, including α, β or γ; E k is the k-th energy of the ν particle radiation type, in MeV; Y k is the yield of ν particles with energy E per decay of the radionuclide; M k is the mass of the source tissue / organ i, in kg; M i is the mass of the target tissue / organ j, in kg; M j is the mass of the external source environmental medium m, in kg; m is the mass of the external source environmental medium m, in kg;

[0023] φ v,i,j (E k ) is the energy absorption fraction of ν particles with energy E emitted per time in the source tissue / organ i and absorbed by the target tissue / organ j; k is the energy absorption fraction of ν particles with energy E emitted per time in the source tissue / organ i and absorbed by the target tissue / organ j;

[0024] φ v,m,j (E k ) is the energy absorption fraction of ν particles with energy E emitted per time in the external source environmental medium m and absorbed by the target tissue / organ j. k is the energy absorption fraction of ν particles with energy E emitted per time in the external source environmental medium m and absorbed by the target tissue / organ j.

[0025] Furthermore, in the step S4,

[0026] The internal irradiation dose rate:

[0027] The external irradiation dose rate:

[0028] The total dose rate:

[0029] In the formula: ω R,v is the radiation weighting factor. For internal irradiation, take 10 for α radiation, 3 for low-energy β radiation, and 1 for non-low-energy β and γ radiation; for external irradiation, take 1 for non-low-energy β and γ radiation, and do not consider α and low-energy β;

[0030] CR b,i is the concentration factor; C a,q is the activity concentration of the radionuclide A in the external environmental medium m, in Bq / kg or Bq / L; R is the residence factor of the organism in this environmental medium;

[0031] Among them, the bioconcentration factor of the aquatic ecosystem is: In the formula, C b,i is the fresh weight activity concentration in the organism, in Bq / kg, Ca,q is the activity concentration in water, with the unit of Bq / L.

[0032] Furthermore, the estimated result of the radiation dose rate of the model organism zebrafish is compared with the result of the international radiation impact assessment program ERICA, and it is weighted according to the activity concentration and geometric size of the organism.

[0033] Furthermore, the estimated radiation dose rate of the model organism zebrafish includes water 137 the influence of Cs concentration on the Cs concentration in zebrafish, and use a high-purity germanium γ spectrometer to measure the Cs activity concentration in water and zebrafish, and calculate the concentration factor of the model organism zebrafish. 137 Cs concentration in zebrafish, and calculate the concentration factor of the model organism zebrafish. 137 Cs activity concentration, and calculate the concentration factor of the model organism zebrafish.

[0034] Furthermore, the step S1 includes collecting samples of the model organism zebrafish, weighing it, measuring its external shape parameters, using a stereomicroscope to anatomize it according to the distinguished parts, and measuring the external shape parameters and mass of each part respectively; the parts include bones, internal organs and ovaries.

[0035] The present invention also discloses a zebrafish radiation dose estimation device based on a simplified anatomical model, including at least one processing unit for executing the zebrafish radiation dose estimation method based on the simplified anatomical model as described above, and outputting the estimated result of the radiation dose rate of the model organism zebrafish.

[0036] Furthermore, it includes:

[0037] a memory for storing programs or instructions, and the programs or instructions are used to be loaded and executed by the processor to perform steps, such as the zebrafish radiation dose estimation method based on the simplified anatomical model as described above;

[0038] an input module for receiving the anatomical parameters of the zebrafish and generating a simplified anatomical model;

[0039] a simulation module for performing Monte Carlo simulation based on the simplified anatomical model and calculating the radiation dose.

[0040] The present invention also discloses a computer-readable storage medium, on which programs or instructions are stored, and when the programs or instructions are executed by a processor, the zebrafish radiation dose estimation method based on the simplified anatomical model as described in any one of the above is implemented.

[0041] Beneficial effects:

[0042] 1. Improve the calculation accuracy: Different from the existing ellipsoid model, the present invention uses a simplified anatomical model to distinguish different tissue organs of zebrafish, so as to more accurately estimate the radiation dose, especially more accurately when dealing with radiation-sensitive organs.

[0043] 2. Simplified model construction: Compared with complex anatomical models, the simplified anatomical model adopted in the present invention has an ellipsoid as the main shape, which not only simplifies the calculation process but also ensures high calculation accuracy and is suitable for practical applications.

[0044] 3. Compatibility with the ERICA program: The method of the present invention is compatible with existing radiation impact assessment programs, and the effectiveness of the method is verified by comparing with its calculation results, having good application prospects. Description of the Drawings

[0045] Figure 1 For the water body in Embodiment 1 of the present invention 137 Cs activity and in the zebrafish body 137 Change value of Cs concentration;

[0046] Figure 2 Longitudinal sectional view of the model organism zebrafish in Embodiment 1 of the present invention;

[0047] Figure 3 Transverse sectional view of the model organism zebrafish in Embodiment 1 of the present invention;

[0048] Figure 4 Top view sectional view of the model organism zebrafish in Embodiment 1 of the present invention;

[0049] Figure 5 Comparison chart of operation results in Embodiment 1 of the present invention. Detailed Description of the Invention

[0050] The present invention will be further described in detail below in conjunction with the description of the drawings and the detailed description of the invention.

[0051] Embodiment 1: Method for estimating zebrafish radiation dose based on a simplified anatomical model

[0052] The present invention discloses a method for estimating zebrafish radiation dose based on a simplified anatomical model, a method for establishing a Monte Carlo simplified anatomical model for estimating the dose rate of the model organism zebrafish, including the following steps:

[0053] S1. Anatomical measurement and weighing of the model organism zebrafish

[0054] Collect samples of the model organism zebrafish, weigh them, and measure their external shape parameters. Use a stereomicroscope to anatomize according to the distinguished parts, and measure the external shape parameters and masses of each part respectively.

[0055] S2. Geometric description of each tissue / organ

[0056] Draw a sketch based on the measured parameters of the model organism zebrafish, mark the obtained geometric parameters in the figure. Approximate each part with geometric bodies, determine the involved surfaces of each part, give the surface equations and the mutual relationships between the surfaces.

[0057] Table 1 Geometric parameters of the simplified anatomical model of zebrafish

[0058]

[0059]

[0060] S3. Monte Carlo model establishment

[0061] According to the format of the input file in the Monte Carlo software MCNP, write the relationship between each surface and the surface composition of each part into the MCNP input file, and run to obtain the model organism zebrafish model and the sectional views of different sections as shown in Figure 2-4 Figure, including. Bone 1, viscera 2, ovary 3 and the whole zebrafish 4.

[0062] S4. Dosage rate estimation of the model organism zebrafish

[0063] Using the established Monte Carlo simplified anatomical model of the model organism zebrafish, write the source file, run to obtain the deposited energy of particles with different energies, and substitute the obtained results into the dose coefficient DCC calculation formula to calculate the internal and external irradiation dose coefficients of the model organism zebrafish. The calculation formula is as follows:

[0064] Internal irradiation dose coefficient

[0065]

[0066] External irradiation dose coefficient

[0067]

[0068] In the formula:

[0069] 5.76×10-4 —— Conversion coefficient from MeV / s to μJ / h;

[0070] ν —— Radiation type (α, β or γ);

[0071] E k —— The kth energy of the ν particle radiation type, MeV;

[0072] Y k —— The yield of ν particles with energy E per decay of the radionuclide, 1; k of ν particles, 1;

[0073] M i—— Mass of the source tissue / organ i, kg;

[0074] M j —— Mass of the target tissue / organ j, kg;

[0075] φ v,i,j (E k ) —— Energy absorption fraction of ν particles with energy E per emission in the source tissue / organ i absorbed by the target tissue / organ j; k

[0076] M m —— Mass of the external source environmental medium m, kg;

[0077] φ v,m,j (E k ) —— Energy absorption fraction of ν particles with energy E per emission in the external source environmental medium m absorbed by the target tissue / organ j. k

[0078] Adult zebrafish were reared in an aqueous solution of 137 Cs at 1000 Bq / L for 58 days. The 137 Cs activity concentrations in the water and zebrafish were measured using a high-purity germanium γ spectrometer. Among them, the 137 Cs activity concentration in zebrafish was measured by in vivo measurement method. Figure 1 is the change value of the 137 Cs activity concentration measured experimentally in the water and zebrafish. When the 137 Cs activity concentration level in zebrafish and the 137 Cs activity concentration level in water reach dynamic equilibrium simultaneously, the concentration factor of 137 Cs in zebrafish is calculated to be 5.81 ± 0.23 (Bq / kg) / (Bq / L) according to Equation 1.

[0079] The bioconcentration factor of the aquatic ecosystem is:

[0080]

[0081] where C b,i is the activity concentration of fresh weight in the organism (Bq / kg), and C a,q is the activity concentration in the water (Bq / L).

[0082] Substitute into the dose rate calculation formula to calculate the total average dose rate of the model organism zebrafish. The dose rate calculation formula is as follows:

[0083] Internal exposure dose rate:

[0084] External exposure dose rate:

[0085] Total dose rate:

[0086] Where:

[0087] ω R,v —— Radiation weighting factor. For internal exposure, for α radiation, it is 10; for low-energy β radiation, it is 3; for non-low-energy β and γ radiation, it is 1. For external exposure, for non-low-energy β and γ radiation, it is 1, and α and low-energy β are not considered;

[0088] CR b,i —— Concentration factor;

[0089] C a,q —— Activity concentration of nuclide A in external environmental medium m, Bq / kg or Bq / L;

[0090] R —— Residence factor of the organism in this environmental medium.

[0091] S5. Comparison of dose rate estimation results with ERICA

[0092] The activity concentrations of each part of the organism are weighted by mass to obtain the average activity concentration of the organism. The activity concentration and geometric size of the organism are input into the ERICA program, and the dose rates of each part of the organism are obtained by running.

[0093] The simplified anatomical model of the zebrafish, which is the model organism used in this patent, is compared with the results obtained by running the ERICA method to verify the model.

[0094] In the environmental medium where zebrafish live 137 The concentration gradient change range of Cs is 50 Bq / L to 400 Bq / L, with a gradient interval of 10 Bq / L. Calculate the internal and external exposure dose rates and total dose rate of the overall zebrafish model and the simplified anatomical model. At the same time, input the above 137 Activity concentration of Cs, relevant parameters and information of zebrafish into the ERICA (1.3) software tool. ERICA (Environmental Risk from Ionizing Contamination: Assessment and Management) is a relatively comprehensive method used to solve scientific, management and social problems related to the environmental impact of radioactive pollutants.

[0095] Reconstruct the zebrafish model in the ERICA software tool, and use the second level in the ERICA software tool to calculate the total dose rate of zebrafish exposed to 137 Cs.

[0096] As Figure 5 shown, the horizontal axis in the figure represents the activity concentration of the radioactive substance (Cs), with the unit of becquerel per liter (Bq / L), ranging from 0 to 450 Bq / L. The vertical axis represents the dose rate, with the unit of microgray per hour (μGy / h), ranging from 0 to 14 μGy / h.

[0097] Internal exposure dose rate.

[0098] External exposure dose rate.

[0099] Total dose rate.

[0100] dose rate of ERICA.

[0101] As can be seen from the figure:

[0102] As the concentration of radioactive substances increases, all dose rates show an upward trend. At low concentrations, both the internal exposure dose rate and the external exposure dose rate are relatively low, but as the concentration increases, the growth rate of the internal exposure dose rate is faster than that of the external exposure dose rate. The total dose rate is the sum of the internal exposure dose rate and the external exposure dose rate, so the growth rate of the total dose rate is between the two. The ERICA dose rate is relatively low throughout the concentration range and has a relatively slow growth rate.

[0103] In the present invention, the simplified anatomical model of zebrafish distinguishes the shapes and structures of different tissues and organs, thus achieving better accuracy in the calculation of the internal exposure dose rate. The Figure 5 results in the appendix verify this: as the concentration of radioactive substances increases, the growth rate of the internal exposure dose rate is faster than that of the external exposure dose rate, which is exactly the embodiment of the biological radiation absorption mechanism that the present invention can accurately simulate.

[0104] The growth trends of the internal exposure dose rate and the external exposure dose rate with increasing concentration are different, and the present invention estimates by distinguishing the radiation doses of different organs in zebrafish. This difference indicates that the traditional ERICA program using a uniform ellipsoid model ignores the radiation absorption effects of different tissues and organs, resulting in a conservative calculation result, while the present invention can provide a more accurate calculation result.

[0105] Appendix Figure 5 provides strong experimental data support for the present invention. By showing the change trends of the radiation dose rates of zebrafish under different concentrations of radioactive substances, Figure 5 the effectiveness and superiority of the method for estimating the radiation doses of different tissues and organs by the simplified anatomical model of the present invention are verified, especially in accurately estimating the internal exposure dose rate. In comparison with the existing ERICA program, the present invention shows more accurate dose rate calculations, with strong innovation and application prospects.

[0106] Example 2: Zebrafish Radiation Dose Estimation Device Based on Simplified Anatomical Model

[0107] This embodiment provides a zebrafish radiation dose estimation device based on a simplified anatomical model. This device can execute the radiation dose estimation method described in Embodiment 1 and specifically includes the following modules:

[0108] Processing Unit (Processor):

[0109] This processing unit is used to execute a predetermined program and implement all steps in the zebrafish radiation dose estimation method based on the simplified anatomical model, such as steps S1 to S5. The processing unit calculates based on the input data and outputs the final radiation dose estimation result.

[0110] Memory:

[0111] The memory is used to store programs or instructions. These programs or instructions are loaded and executed by the processor to implement the zebrafish radiation dose estimation method based on the simplified anatomical model as described in Embodiment 1. The memory stores the required model data, formulas, and other parameters needed for radiation dose calculation.

[0112] Input Module:

[0113] The input module is used to receive the anatomical parameters of the zebrafish and generate a simplified anatomical model. The input module supports importing the measurement data and geometric parameters (such as length, width, height, mass, etc.) of the zebrafish into the system for subsequent calculations.

[0114] Simulation Module:

[0115] The simulation module performs Monte Carlo simulations according to the simplified anatomical model, calculates the deposited energy of particles with different energies, and finally calculates the internal and external irradiation dose coefficients of the zebrafish.

[0116] Output Module:

[0117] The output module is used to display the radiation dose estimation result, display the dose rates of different tissues and organs, compare with other evaluation methods (such as the ERICA program), and provide a final radiation dose estimation report.

[0118] Through the above components, this device can completely execute the zebrafish radiation dose estimation process, from inputting anatomical data to calculating the radiation dose, and then to the final comparison and report generation.

[0119] Example 3: Computer-Readable Storage Medium

[0120] This embodiment provides a computer-readable storage medium, which contains a program or instruction for executing a zebrafish radiation dose estimation method based on a simplified anatomical model. The computer-readable storage medium may include, but is not limited to: hard disk drive (HDD), solid state drive (SSD), optical disc storage medium, and USB flash drive storage device.

[0121] When the program or instruction stored in the storage medium is executed by a processor, the following tasks will be automatically completed:

[0122] 1. Generate a simplified anatomical model according to zebrafish anatomical parameters;

[0123] 2. Based on this model, calculate the radiation dose through Monte Carlo simulation;

[0124] 3. Substitute into the dose coefficient calculation formula and output the radiation dose of the zebrafish;

[0125] 4. Compare the calculation results with the results of the ERICA program;

[0126] 5. Generate a final radiation dose estimation report.

[0127] The execution of the program or instruction on the storage medium will complete the entire radiation dose estimation process from data input to final result output, helping researchers or engineers accurately evaluate the dose of zebrafish in a specific radiation environment.

[0128] Through the specific descriptions of Example 1, Example 2, and Example 3, the application of the zebrafish radiation dose estimation method, device, and computer-readable storage medium based on the simplified anatomical model of the present invention is fully demonstrated. It can achieve a higher-precision radiation dose assessment, especially in terms of the accuracy of radiation dose estimation for different tissues and organs, and has significant advantages compared with the prior art. Through the implementation of the present invention, a more scientific radiation environment impact assessment can be carried out, which is widely applied in the fields of radiation protection, ecological environment monitoring, etc., and has broad application prospects.

[0129] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A zebrafish radiation dose estimation method based on a simplified anatomical model, characterized in that: The steps include: S1. Measure the appearance parameters and quality of zebrafish as a whole, as well as bones, internal organs and ovaries; S2. Draw a sketch based on the measured parameters of the model organism zebrafish, mark the obtained geometric parameters, and use geometric bodies to approximate and simplify the shapes of the zebrafish as a whole, as well as the bones, internal organs and ovaries, determine the surface equations of each part and their mutual relationships, and form a simplified anatomical model; S3. Based on the simplified anatomical model established in step S2, each surface and its relationship are written into the input file format of the Monte Carlo simulation software, and the simulation is run to obtain the model organism zebrafish model and cross-sectional views of different sections to form a Monte Carlo simplified anatomical model; S4. Zebrafish dose rate estimation: Using the established Monte Carlo simplified anatomical model, compile source files, run simulations to obtain the deposition energy of particles with different energies, substitute them into the dose coefficient calculation formula, and calculate the internal and external irradiation dose coefficients of the model organism zebrafish; S5. Weight the activity concentration of each part of the model organism zebrafish according to the mass to obtain the average activity concentration of the organism, and input the concentration and geometric dimensions into the ERICA program to run to obtain the dose rate of each part of the organism.

2. The zebrafish radiation dose estimation method based on a simplified anatomical model according to claim 1, characterized in that: The overall surface equation of the zebrafish is: The surface equation of the zebrafish skeleton is: The surface equation of zebrafish viscera is: The surface equation of the zebrafish ovary is:

3. The zebrafish radiation dose estimation method based on a simplified anatomical model according to claim 1, characterized in that: In step S4, the internal irradiation dose coefficient of zebrafish is: The external irradiation dose factor for zebrafish is: Where: 5.76×10-4 is the conversion factor from MeV / s to μJ / h; ν is the radiation type, including α, β or γ; E k is the kth energy of the ν particle radiation type, in MeV; Y k The energy of each decay of the radioactive nuclide is E k The yield of ν particles; M i is the mass of source tissue / organ i, in kg; M j is the mass of target tissue / organ j, in kg; M m is the mass of the external source environment medium m, in kg; φ v,i,j (E k ) is the energy per emission in source tissue / organ i, which is E k The energy absorption fraction of the ν particles absorbed by the target tissue / organ j; φ v,m,j (E k ) is the external source environment medium m, and each emission has an energy of E k The energy absorption fraction of ν particles absorbed by target tissue / organ j.

4. The zebrafish radiation dose estimation method based on a simplified anatomical model according to claim 3, characterized in that: In step S4, Internal radiation dose rate: External radiation dose rate: Total dose rate: Where: R,v is the radiation weight factor. For internal irradiation, α radiation takes 10, low-energy β radiation takes 3, and non-low-energy β and γ radiation take 1. For external irradiation, non-low-energy β and γ radiation take 1, and α and low-energy β are not considered. CR b,i is the concentration factor; C a,q is the activity concentration of the nuclide A in the external environmental medium m, in Bq / kg or Bq / L; R is the residence factor of organisms in the environmental medium; Among them, the bioconcentration factor of aquatic ecosystem is: In the formula, C b,i is the fresh weight activity concentration in the organism, unit is Bq / kg, C a,q It is the activity concentration in water, unit is Bq / L.

5. The zebrafish radiation dose estimation method based on a simplified anatomical model according to claim 3, characterized in that: The radiation dose rate estimates for the model organism zebrafish are compared with those from ERICA, an international radiation impact assessment program, and are weighted according to the activity concentration and geometric size of the organism.

6. The method for estimating zebrafish radiation dose based on a simplified anatomical model according to claim 5, characterized in that: The radiation dose rate estimation of the model organism zebrafish includes water 137 Effects of Cs concentration on zebrafish 137 The influence of Cs concentration was measured in water and zebrafish using a high purity germanium gamma spectrometer. 137 The Cs activity concentration was used to calculate the concentration factor of the model organism zebrafish.

7. The method for estimating zebrafish radiation dose based on a simplified anatomical model according to any one of claims 1 to 6, characterized in that: The step S1 includes collecting a sample of a model organism zebrafish, weighing it, measuring its appearance parameters, dissecting it according to the differentiated parts using a stereo microscope, and measuring the appearance parameters and mass of each part respectively; the parts include bones, internal organs and ovaries.

8. A zebrafish radiation dose estimation device based on a simplified anatomical model, characterized in that: The method comprises at least one processing unit, which is used to execute the zebrafish radiation dose estimation method based on the simplified anatomical model as described in any one of claims 1 to 7, and output the radiation dose rate estimation result of the model organism zebrafish.

9. The device for estimating zebrafish radiation dose based on a simplified anatomical model according to claim 8, characterized in that: include: A memory for storing a program or instruction, wherein the program or instruction is used to load and execute steps through the processor, the method for estimating zebrafish radiation dose based on a simplified anatomical model according to any one of claims 1 to 7; An input module, used for receiving anatomical parameters of zebrafish and generating a simplified anatomical model; Simulation module for performing Monte Carlo simulations based on simplified anatomical models and calculating radiation doses.

10. A computer-readable storage medium, characterized in that: The readable storage medium stores a program or instruction, and when the program or instruction is executed by the processor, the method for estimating zebrafish radiation dose based on a simplified anatomical model as described in any one of claims 1 to 7 is implemented.

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