Compound functional sugar for preventing oral diseases and protecting oral health

Abstract

The invention belongs to the technical field of functional sugar compounds, and particularly relates to a compound functional sugar capable of preventing oral diseases and protecting oral health. The solid beverage is prepared from the following raw materials in percentage by mass: 55%-60% of xylitol, 30%-34% of erythritol, 4%-6% of galactomannan, 2%-4% of pleurotus eryngii polysaccharide, 1%-2% of stevioside, 0.05%-0.1% of chlorhexidine gluconate, 0.03%-0.08% of sodium fluoride and 0.01%-0.03% of natural catechin. According to the compound functional sugar product provided by the invention, the functional sugar and the oral hygiene raw materials are compounded for use, the effects are complementary and synergistic, and the best oral health effect is played, for example, xylitol and sodium fluoride have a synergistic effect, and the demineralization inhibition and remineralization promotion effects of the compound functional sugar product can be improved by adding xylitol with a certain concentration into sodium fluoride; fluorine atoms and xylitol cooperate with each other to prevent caries, so that the caries-preventing effect is better.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional sugar complexes, and particularly relates to a compound functional sugar for preventing oral diseases and protecting oral health. Background Art

[0002] With the improvement of people's health awareness, oral health has gradually become the focus of public attention. The World Health Organization's "Global Oral Health Status Report" released in 2022 pointed out that half of the approximately 3.5 billion people in the world have oral problems. According to the "2023 JD.com Oral Care Industry Trend Insights White Paper", the number of people with oral problems in China has reached 710 million, and the market size of oral care has reached 128.5 billion yuan. Oral health problems include tooth yellowing, bad breath, gum bleeding, tooth decay, dental caries, periodontitis, etc. Currently, studies believe that harmful bacteria such as Gram-negative anaerobic bacteria Porphyromonas gingivalis and Staphylococcus can cause periodontal diseases, Candida albicans can cause oral mucosal infections, Streptococcus mutans mainly causes dental caries, and sulfides cause bad breath, etc. These pathogenic bacteria work together to cause the occurrence of oral diseases, and oral diseases have directly or indirectly affected people's physical health and had a serious impact on people's quality of life.

[0003] There are relatively many products reported in current research on preventing and protecting oral health. For example, a Chinese patent for a toothpaste for preventing and treating oral mucosal diseases (CN202411001546.9) discloses a toothpaste for preventing and treating oral mucosal diseases. Its active ingredients include a wild kiwifruit juice extract obtained by mixing wild kiwifruit juice, tea extract, and fructose syrup. Using the antioxidants, vitamin C, and other bioactive ingredients it contains, it achieves the effects of anti-inflammatory and antioxidant, relieving gum swelling and pain, reducing oral inflammation, and promoting the repair and health of the oral mucosa. A Chinese patent for an ondansetron orally disintegrating film and its preparation method (CN202410756744.X) includes ondansetron, fillers, binders, talcum powder, sweeteners, and at the same time adds fluoride, calcium salts, and vitamins to the formula. It can not only provide the antiemetic effect of ondansetron but also effectively inhibit harmful bacteria in the oral cavity and reduce the risk of oral infections. A Chinese patent for an oral health probiotic effervescent tablet and its preparation process (CN202311832878.7) includes Lactobacillus salivarius SL311, Lactobacillus rhamnosus 4F225, Hovenia dulcis, white kidney bean extract, and tremella polysaccharide, which can inhibit pathogenic bacteria in the oral cavity and have an obvious improvement effect on oral ulcers. A Chinese patent for a mouthwash containing an inactivated probiotic composition for improving oral health and its preparation method (CN202311304500.X) includes an inactivated probiotic agent composed of Lactobacillus johnsonii LJ09, Lactobacillus salivarius LS97, Lactobacillus acidophilus LA85, and Lactobacillus plantarum Lp90. Creatively, the four strains are compounded, interact with each other, cooperate with each other, and synergistically enhance the effect. The prepared mouthwash has little irritation and has a good antibacterial effect. A Chinese patent for a pharmaceutical composition with antibacterial effects, its preparation method, and uses (CN202310430813.3), the pharmaceutical composition includes Scutellaria baicalensis, Ligusticum chuanxiong, Angelica sinensis, Gardenia jasminoides, Curcuma aromatica, Allium macrostemon, Bupleurum chinense, Gentiana scabra, Rehmannia glutinosa, Codonopsis pilosula, Plantago asiatica, sweet tea extract, and chlorhexidine. The traditional Chinese medicine extract can significantly improve the antibacterial activity of chlorhexidine, and can also reduce inflammation and repair. It has functions such as oral sterilization, removing oral odor, and cleaning and protecting teeth, and can effectively maintain oral health. A Chinese patent for a postbiotic composition and its application in oral health (CN202211196485.7) discloses that the postbiotic composition includes inactivated Lactobacillus crispatus, yeast β-glucan, and honeysuckle pollen, which can effectively inhibit Porphyromonas gingivalis, Treponema denticola, and Streptococcus mutans in the oral cavity and play a protective role in the oral cavity.Chinese patent: An oral cleaning solution, its preparation method and application (CN202111034757.9). The oral cleaning solution includes edible sodium chloride, plantain extract, Corydalis yanhusuo extract, honeysuckle extract, mint extract, sweetener and deionized water. Taking traditional Chinese herbs as the basis, edible sodium chloride is used for sterilization, plantain extract for hemostasis, Corydalis yanhusuo extract for pain relief, honeysuckle extract for anti - inflammation, and mint extract for deodorization. It is non - toxic and harmless, has a sweet taste, can sterilize and anti - inflame, stop bleeding and relieve pain, will not cause excessive irritation to the oral environment, has no adverse reactions, and has a positive significance for the recovery of oral health. Chinese patent: A chewing gum (CN201810492869.0), including main ingredients and auxiliary ingredients. The main ingredient is maltose, and the auxiliary ingredients are taurine, Houttuynia cordata, ginseng, VC and grape seed extract. Using 100% xylitol as the sweetener, without adding any preservatives and colorants, ensuring that the produced chewing gum is non - toxic and harmless, can care for the oral cavity, clear heat and detoxify, soothe the throat, improve immunity and boost intelligence, achieving the effect of caring for oral health. The above - mentioned oral prevention and protection products such as toothpaste, oral soluble film, effervescent tablets, mouthwash, pharmaceutical composition, post - biotic composition, oral cleaning solution, chewing gum, etc., although they can alleviate the symptoms and conditions of oral diseases to a certain extent, there are also certain limitations and side effects, such as incomplete cleaning, unstable treatment effect, limited treatment range, weak sterilization and disinfection ability, short nursing maintenance time, some have a bitter taste, are easy to stain the tooth surface, and oral bacteria develop drug resistance to traditional Chinese medicine components, etc., which restrict the application of these products.

[0004] Functional sugars are a type of carbohydrate with special physiological effects on humans, animals, and plants, mainly including three categories: functional oligosaccharides, functional dietary fibers, and functional sugar alcohols, and have characteristics such as low calories and the ability to regulate and improve the intestinal flora. Generally, functional sugars are not utilized by microorganisms in the human oral cavity, and unlike sugars, they will not be enzymatically hydrolyzed to produce acid in the oral cavity. For example, the pH value of glucose will drop to 5 after 8 hours in the oral cavity, while the pH value of functional sugar alcohols will not decrease in the oral cavity. Especially for xylitol, the pH value even slightly rises in the oral cavity. Foreign mouse experiments have shown that the caries rate of sucrose is 57%, while that of sorbitol is 18%, maltitol is 16%, and xylitol is 11%. Therefore, functional sugars are excellent raw materials for preparing oral health products. Summary of the Invention

[0005] The purpose of the present invention is to provide a compound functional sugar for preventing oral diseases and protecting oral health to solve the problems existing in the prior art.

[0006] The technical solution adopted by the present invention to solve its technical problems is:

[0007] A compound functional sugar for preventing oral diseases and protecting oral health is prepared from the following raw materials by mass percentage:

[0008] 55 - 60% xylitol, 30 - 34% erythritol, 4 - 6% galactomannan, 2 - 4% Pleurotus eryngii polysaccharide, 1 - 2% stevioside, 0.05 - 0.1% chlorhexidine gluconate, 0.03 - 0.08% sodium fluoride, 0.01 - 0.03% natural catechins.

[0009] Furthermore, the compound functional sugar is in powder or granular form.

[0010] Furthermore, the raw materials of the compound functional sugar also include auxiliary materials.

[0011] Furthermore, the auxiliary materials include but are not limited to CMC and ethanol.

[0012] Furthermore, the preparation method of the compound functional sugar is to take each raw material according to the ratio, mix and stir for 5 - 30 minutes, then weigh and package.

[0013] Furthermore, each raw material is pulverized before taking according to the ratio.

[0014] Furthermore, the preparation method of the compound functional sugar is to pulverize each raw material and then take it according to the ratio. Add xylitol, erythritol, and galactomannan as solid materials into a spray granulator. Dissolve Pleurotus eryngii polysaccharide, stevioside, chlorhexidine gluconate, sodium fluoride, and natural catechins in water, and add auxiliary materials to prepare a liquid material. Pump the liquid material into the spray granulator to spray - granulate the solid materials, and then weigh and package after granulation.

[0015] The present invention has the following beneficial effects:

[0016] 1. The compound functional sugar product provided by the present invention uses the compound of functional sugar and oral hygiene raw materials, with complementary effects and synergistic enhancement, bringing the best effect on oral health. For example, xylitol and sodium fluoride have a synergistic effect. Adding a certain concentration of xylitol to sodium fluoride can improve its effect of inhibiting demineralization and promoting remineralization. Fluorine atoms and xylitol cooperate synergistically to prevent caries, and the anti - caries effect is better.

[0017] 2. The compound functional sugar provided by the present invention is extracted from natural sources, does not contain hormones, is safe and non - toxic, and can be used by people of all ages. At the same time, it is non - irritating, has no burning and irritating sensation, has a comfortable taste, and people with diabetes, sensitive people, etc. can use it with confidence. It is a popular oral health product.

[0018] 3. The compound functional sugar provided by the present invention not only has a strong inhibitory effect on various bacteria and viruses in the human oral cavity, but also can clean the oral cavity, eliminate bad breath, effectively remove dental plaque, dental calculus, prevent caries, strengthen teeth, and has the effects of anti - inflammation, accelerating the repair of oral mucosa, treating oral ulcers, inhibiting the growth of dental plaque, and preventing and treating periodontal diseases.

[0019] 4. The compound functional sugar provided by the present invention has good permeability after entering the mouth, can directly penetrate into dental floss spaces and dental caries. While treating oral diseases, it can also remove bad breath caused by oral diseases, eating odorous foods, indigestion, etc. It is convenient to use, safe, clean and healthy.

[0020] 5. People can directly eat the compound functional sugar provided by the present invention to maintain their own oral health. Or, taking this compound functional sugar product as a raw material, it can be further prepared into oral health products such as mouthwash, toothpaste, effervescent tablets, chewing gum, etc., which is convenient for people to use. Description of the Drawings

[0021] Figure 1 It is a physical map of the microbial colony of the test sample in Example 4 of the present invention.

[0022] Figure 2 It is a physical map of the microbial colony of the control sample in Example 4 of the present invention.

[0023] Figure 3 It is a physical map of the inhibition zone of the test sample in Example 5 of the present invention.

[0024] Figure 4 It is a physical map of the inhibition zone of the control sample in Example 5 of the present invention. Detailed Embodiments

[0025] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the following further describes the present invention in detail with reference to specific embodiments and the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0026] Example 1:

[0027] A compound functional sugar for preventing oral diseases and protecting oral health is prepared from the following raw materials: 550 g of xylitol, 340 g of erythritol, 60 g of galactomannan, 40 g of Pleurotus eryngii polysaccharide, 9.1 g of stevioside, 0.5 g of chlorhexidine gluconate, 0.3 g of sodium fluoride, and 0.1 g of natural catechin.

[0028] After taking each raw material according to the ratio, mix and stir for 30 minutes, then weigh and package to obtain 1 kg of compound functional sugar.

[0029] Example 2:

[0030] This embodiment provides a compound functional sugar for preventing oral diseases and protecting oral health. Its raw material composition and preparation method are basically the same as those of Example 1. The difference is that after crushing each raw material to 100 mesh, the crushed raw materials are taken according to the ratio: 600 g of xylitol, 317.9 g of erythritol, 40 g of galactomannan, 20 g of Pleurotus eryngii polysaccharide, 20 g of stevioside, 1 g of chlorhexidine gluconate, 0.8 g of sodium fluoride, and 0.3 g of natural catechin.

[0031] After taking each raw material according to the ratio, mix and stir for 5 min, then weigh and package to obtain 1 kg of compound functional sugar.

[0032] Example 3:

[0033] A compound functional sugar for preventing oral diseases and protecting oral health, its raw material composition is basically the same as that of Example 1. The difference is that after crushing each raw material to 100 mesh, the crushed raw materials are taken according to the ratio: 59.15 kg of xylitol, 30 kg of erythritol, 5.9 kg of galactomannan, 2.9 kg of Pleurotus eryngii polysaccharide, 1.9 kg of stevioside, 0.08 kg of chlorhexidine gluconate, 0.05 kg of sodium fluoride, and 0.02 kg of natural catechin. Add xylitol, erythritol, and galactomannan as solid materials to a spray granulator. Dissolve Pleurotus eryngii polysaccharide, stevioside, chlorhexidine gluconate, sodium fluoride, and natural catechin in water, and add CMC to prepare a liquid material. Pump the liquid material into the spray granulator to spray granulate the solid material, and then weigh and package after granulation.

[0034] Example 4:

[0035] This embodiment is an antibacterial effect test of the compound functional sugar product prepared in Example 1.

[0036] Take the compound functional sugar product prepared in Example 1, add an appropriate amount of purified water to prepare a mouthwash with a dry matter concentration of 0.1%, as the test sample. Then find 20 volunteers with oral diseases as the test subjects, and use the mouthwash continuously for 6 months, 2 times a day, once in the morning and once in the evening, about 15 ml each time. The detection method is the method specified in the "National Food Safety Standard - Food Microbiology Examination - Total Colony Count Determination" (GB 4789.2 - 2016) of the People's Republic of China. Samples are taken when the volunteers do not use the mouthwash as the control sample, and samples are taken after the volunteers use the mouthwash for 6 months as the test sample.

[0037] The sampling and test method is: Use a sterile cotton swab to sample and mix the teeth, tongue, throat and other parts in the volunteers' oral cavities. At the same time, to ensure that the total number of colonies detected is clear, countable and within the standard range, the test samples are diluted 10 -1 、10 -2 、10-3 and 10 -4 Four dilutions, using plate count agar as the culture medium, were cultured at 36°C ± 1 for 48 h ± 2 h. The culture results are as Figure 1-2 shown.

[0038] From Figure 1-2 the agar plates, it can be seen that when the volunteers did not use the mouthwash, the total number of microbial colonies in their oral cavities was more than 7×10 4 colonies. After continuously using the mouthwash prepared from the raw materials of the present invention for 6 months, the total number of microbial colonies in their oral cavities decreased to 3×10 4 colonies, a decrease of 57.1% compared with before use. It has a good effect, and also shows that the compound functional sugar product of the present invention can kill the pathogenic bacteria causing oral diseases, effectively reduce oral odor, and maintain oral health.

[0039] Example 5:

[0040] This example is the bacteriostatic ring test of the compound functional sugar product prepared in Example 1.

[0041] The occurrence of oral diseases such as dental caries and ulcers is usually related to oral bacteria. For example, various bacteria such as Lactobacillus, Streptococcus mutans, and Actinomyces jointly affect the degree of tooth damage. Bacteria such as Escherichia coli and Staphylococcus aureus will also grow and reproduce in large numbers. Porphyromonas gingivalis is a pathogenic bacterium of periodontal disease, etc. Referring to the relevant methods and regulations of the bacteriostatic ring test in the "Disinfection Technical Specification" (2012 edition), a bacteriostatic ring test of Staphylococcus aureus was conducted on the volunteers in Example 4. Samples were taken when the volunteers did not use the mouthwash as the control sample, and samples were taken after the volunteers used the mouthwash for 6 months as the test sample.

[0042] The sampling and test methods were as follows: Use a sterile cotton swab to wipe and dip the oral cavity of the volunteers, and then dilute it by 10 -1 and 10 -2 and 10 -3 and 10 -4 four gradients. According to the requirements of the "Disinfection Technical Specification", use a pipette gun to transfer 1 ml and transfer it to the nutrient agar medium, and culture it in a constant temperature incubator at 37°C. The culture time should not be too long or too short. After culturing for 18 h, take it out and measure the diameter of the Staphylococcus aureus bacteriostatic ring with a vernier caliper. Take a representative Staphylococcus aureus petri dish. The results are as Figure 3-4 shown.

[0043] Through Figure 3-4From the comparison of the diameters of the inhibition zones, it can be seen that when the tested volunteers did not use the mouthwash, the diameter of the inhibition zone of Staphylococcus aureus was about 7 mm. After continuously using the mouthwash prepared from the raw materials of the present invention for 6 months, the diameter of the inhibition zone of Staphylococcus aureus decreased to about 2.5 mm. The mouthwash prepared from the raw materials of the present invention has a significant and good inhibitory effect on Staphylococcus aureus.

[0044] The working principle of the present invention is:

[0045] The single-functional sugar raw materials such as xylitol, erythritol, galactomannan, Pleurotus eryngii polysaccharide, and stevioside selected in the present invention are all used in accordance with the National Food Safety Standard - Standard for the Use of Food Additives (GB 2760-2024) and used in appropriate amounts as required by production. They are foods or food additives that can be used as sweeteners and oral health raw materials in oral health products and have a certain inhibitory effect on oral bacteria. Among them:

[0046] Xylitol is a commonly used raw material in oral health products. It has a certain antibacterial effect, can directly affect the proliferation of pathogenic bacteria, can also increase the release of oral saliva, play a flushing role on oral bacteria, reduce the residue of bacteria in the oral cavity, and at the same time can also induce subsurface remineralization of demineralized enamel by accelerating the absorption of Ca 2+ ; Erythritol is the natural functional sugar product with the smallest molecular weight, zero calories, high resistance to microorganisms, not easy to ferment, not utilized by microorganisms such as Streptococcus mutans, and has anti-caries effect; The sweetness of stevioside is 250 times that of sucrose, not absorbed by the human body, calorie-free, does not cause tooth decay, has the effect of inhibiting the growth and replication of bacteria, can reduce the incidence of cold symptoms, and can inhibit the growth of bacteria in the mouth when added to oral cleaning products; Galactomannan appears as a white powder, odorless, tasteless, acid-resistant, salt-resistant, has good thermal stability, is soluble in water, can promote the proliferation of Bifidobacterium, has antibacterial, anti-inflammatory and hypoglycemic effects, and can be used in appropriate amounts as required by production; Pleurotus eryngii polysaccharide is a polysaccharide containing a variety of active substances extracted from the edible fungus Pleurotus eryngii, and has activities such as antihypertensive, antibacterial, anti-inflammatory, antiviral, anti-diabetic, lipid-lowering, anti-tumor, immune regulation and antioxidant.

[0047] Other substances beneficial to oral hygiene and health selected in the present invention also have significant effects on preventing oral diseases and protecting oral health. Among them:

[0048] Chlorhexidine gluconate has the functions of anti-inflammatory, accelerating the repair of oral mucosa, and treating oral ulcers. It has been proven to be able to effectively inhibit the growth of dental plaque and prevent periodontal diseases; sodium fluoride can play a role in preventing dental caries and effectively prevent tooth decay. The action of sodium fluoride and tooth enamel can form fluorapatite on the surface of tooth enamel, improve the hardness and acid resistance of tooth enamel, and can reduce the formation of dental plaque and the incidence of dental caries; natural catechins are rich in vitamins, with strong bactericidal, anti-caries, and antioxidant properties. Catechins can penetrate into tooth gaps and cavities, effectively inhibit bacteria, and protect the oral cavity clean and healthy.

[0049] The above embodiments merely describe the preferred embodiments of the present invention, and do not limit the concept and scope of the present invention. Without departing from the design concept of the present invention, various modifications and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope of the present invention.

[0050] The technologies, shapes, and structures not described in detail in the present invention are all well-known technologies.

Claims

1. A composite functional sugar for preventing oral diseases and protecting oral health, characterized in that: According to the weight percentage, it is prepared from the following raw materials: 55-60% xylitol, 30-34% erythritol, 4-6% galactomannan, 2-4% Pleurotus eryngii polysaccharide, 1-2% stevioside, 0.05-0.1% chlorhexidine gluconate, 0.03-0.08% sodium fluoride, 0.01-0.03% natural catechins.

2. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 1, characterized in that: The compound functional sugar is in powder or granular form.

3. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 2, characterized in that: The raw materials of the compound functional sugar also include auxiliary materials.

4. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 3, characterized in that: The auxiliary materials include but are not limited to CMC.

5. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 2, characterized in that: The preparation method of the compound functional sugar comprises the following steps: taking the raw materials according to the proportion, mixing and stirring for 5-30 minutes, and then weighing and packaging.

6. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 5, characterized in that: The raw materials are crushed before taking them according to the proportion.

7. The composite functional sugar for preventing oral diseases and protecting oral health according to claim 3, characterized in that: The preparation method of the composite functional sugar comprises the following steps: crushing the raw materials and taking the materials according to the proportion, adding xylitol, erythritol and galactomannan as solid materials into a spray granulator, dissolving Pleurotus eryngii polysaccharide, stevioside, chlorhexidine gluconate, sodium fluoride and natural catechins in water, adding auxiliary materials to prepare liquid materials, pumping the liquid materials into the spray granulator to spray granulate the solid materials, and weighing and packaging the solid materials after granulation.

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