Sampling device and method for HPV (human papillomavirus) detection and screening

Abstract

The invention relates to the technical field of medical detection sampling, in particular to a sampling device and method for HPV (human papillomavirus) detection and screening. The sampling device comprises a sampling tube with an opening in the bottom, a rotating rod is rotatably mounted at the top of the sampling tube through a bearing in a penetrating manner, and a sampling brush is arranged at the top end of the rotating rod; the sampling tube is also provided with a cleaning mechanism for scraping off the exfoliated cells attached to the surface of the sampling brush; in the cleaning mechanism, a reciprocating plate drives an annular scraping plate to reciprocate up and down through a connecting rod in the up-and-down reciprocating movement process, and the annular scraping plate can scrape off the exfoliated cells adhered to the sampling brush and fall into the solution in the reciprocating movement process; therefore, cast-off cells adhered to the sampling brush can be washed into the solution as much as possible, the concentration of the solution is ensured, and the subsequent detection effect is prevented from being influenced by low concentration of the solution.

Description

Technical Field

[0001] This application relates to the technical field of medical detection sampling, and particularly relates to a sampling device and method for HPV detection and screening. Background Art

[0002] Currently, early detection and prevention of cervical cancer are the keys to ensuring women's health. Human papillomavirus (HPV) is the main pathogenic factor causing cervical cancer. Therefore, HPV detection plays an important role in the screening and prevention of cervical cancer. Currently, the conventional HPV detection methods mainly analyze cervical cells collected through biopsy or colposcopy.

[0003] For example, the patent application with the publication number CN116570322A discloses an HPV and vaginal exfoliated cell sampling device and its usage method. The device consists of a reagent kit and a sampler. The sampler includes a hollow handle, a brush head, and a push rod. The outer shell is sleeved around the brush head and the handle, and a through hole is opened at the distal end to assist the brush head to enter the vagina and collect exfoliated cells. The sampling process only requires simply inserting the outer shell of the sampler into the vagina, pulling out the outer shell to expose the brush head, rotating the brush head several times to collect the sample, and then pushing it into the reagent kit for preservation. The whole process is convenient and efficient. The working principle of this device is that the through hole design of the outer shell facilitates the brush head to enter the vagina. The connection design of the handle with the brush head and the push rod ensures the rotation and release of the brush head. The length of the push rod is greater than that of the handle, enabling the brush head to fully penetrate into the vagina and collect the sample. The brush head can preserve the HPV RNA and exfoliated cells together by contacting the collection liquid in the reagent kit for subsequent detection and analysis.

[0004] The collected exfoliated cells adhere to the brush head. At this time, it is necessary to wash the brush head with adhered exfoliated cells to obtain the solution to be detected, and then the sampling detection effect can be obtained by analyzing the solution to be detected.

[0005] However, when the prior art extracts samples from the brush head with adhered exfoliated cells, it only simply swings the brush head in the extraction liquid to wash and obtain the solution. The washing process is not thorough, resulting in the exfoliated cells on the brush head not completely falling into the solution, thereby causing a low sample content in the solution and affecting the subsequent detection accuracy. Summary of the Invention

[0006] In order to solve the above technical problems, this application provides a sampling device and method for HPV detection and screening, adopting the following technical solutions:

[0007] In a first aspect, a sampling device for HPV detection and screening includes a sampling tube with an opening at the bottom. A rotating rod is rotatably installed through the top of the sampling tube by means of a bearing. A sampling brush is provided at the top of the rotating rod. The sampling tube is also provided with a cleaning mechanism for scraping off the exfoliated cells attached to the surface of the sampling brush.

[0008] The described cleaning mechanism includes: a reciprocating plate, which is limited and slidably arranged on the inner wall of the sampling tube, and the rotating rod penetrates through the reciprocating plate.

[0009] Connecting rods, which are symmetrically arranged along the length direction of the reciprocating plate. A circular scraping plate is commonly installed at the bottom of the connecting rods, and the circular scraping plate and the rotating rod are coaxial.

[0010] Preferably, a double-thread that cooperates with the reciprocating plate is provided on the rotating rod.

[0011] Preferably, a sleeve rod that reciprocates along its length direction is limited and slidably sleeved on the bottom circumferential surface of the rotating rod, and is installed at the bottom of the sleeve rod in a detachable manner.

[0012] Preferably, a linkage ring is provided on the circumferential surface of the sleeve rod. Limiting rods are symmetrically arranged on the circumferential surface of the linkage ring along the width direction of the reciprocating plate, and the end of the limiting rod far from the linkage ring is slidably arranged on the inner wall of the sampling tube.

[0013] Preferably, an annular plate that cooperates with the linkage ring is installed on the rotating rod. A plurality of arc-shaped protrusions are evenly arranged on the top of the annular plate along its circumference. A linkage rod is provided on the linkage ring, and the end of the linkage rod far from the linkage ring cooperates with the arc-shaped protrusion.

[0014] Preferably, a stirring frame is rotatably arranged at the bottom of the circumferential surface of the sampling tube, and a plurality of stirring rods are evenly arranged at the bottom of the stirring frame along its circumference.

[0015] Preferably, the stirring rod is arranged in a bent structure with two vertical sections and one horizontal section. The vertical section of the stirring rod far from the rotating rod is installed on the stirring frame, and the vertical section of the stirring rod close to the rotating rod is close to the sampling brush.

[0016] Preferably, a plurality of gear teeth are evenly arranged on the circumferential surface of the stirring frame along its circumference. A fixed protrusion is provided on the circumferential surface of the sampling tube. A rotating shaft extending along the length direction of the sampling tube is rotatably installed through the fixed protrusion by a bearing, and a first gear meshing with the gear teeth is installed at the bottom of the circumferential surface of the rotating shaft.

[0017] Preferably, a second gear is installed at the top of the circumferential surface of the rotating shaft, and a third gear meshing with the second gear is installed at the top of the circumferential surface of the rotating rod.

[0018] In a second aspect, a sampling method for HPV detection and screening, its usage method includes the following steps: S1: Sampling treatment, using a sampling brush to dip into human exfoliated cells to obtain a sample.

[0019] S2: Installation treatment, snap the sampling brush dipped with the sample onto the bottom of the sleeve rod.

[0020] S3: Washing treatment, washing the sampling brush to obtain the solution to be detected.

[0021] S4: Absorb the solution, and then absorb the solution to be detected to prepare for subsequent detection.

[0022] In summary, the present application includes at least one of the following beneficial technical effects:

[0023] 1. During the rotation of the rotating rod designed in the present invention, the inertial force is utilized to throw the exfoliated cells adhered to the sampling brush into the solution. In the cleaning mechanism, during the reciprocating up and down movement of the reciprocating plate, the connecting rod drives the annular scraper to reciprocate up and down. During the reciprocating movement of the annular scraper, the exfoliated cells adhered to the sampling brush can be scraped off and fall into the solution, thereby ensuring that the exfoliated cells adhered to the sampling brush can be washed into the solution as much as possible, ensuring the concentration of the solution, and avoiding the influence of low solution concentration on the subsequent detection effect.

[0024] 2. When the sleeve rod designed in the present invention reciprocates along the length direction of the rotating rod, it can drive the sampling brush to vibrate reciprocally, thereby vibrating off the exfoliated cells attached to its surface during the rotation of the sampling brush, and further ensuring that the exfoliated cells adhered to the sampling brush can be washed into the solution.

[0025] 3. During the rotation of the stirring frame designed in the present invention, the stirring rod is driven to rotate synchronously. During the rotation of the stirring rod, it can stir the solution near the sampling brush to flow, thereby flushing the exfoliated cells adhered to the sampling brush and ensuring the washing effect of the sampling brush. Description of the Drawings

[0026] Figure 1 is a three-dimensional structural schematic diagram of the present invention.

[0027] Figure 2 is a three-dimensional internal structural schematic diagram of the present invention.

[0028] Figure 3 is the present invention Figure 2 partial enlarged view of part A.

[0029] Figure 4 is the present invention Figure 2 partial enlarged view of part B.

[0030] Figure 5 is a three-dimensional installation structural schematic diagram between the stirring frame, the stirring rod and the like of the present invention.

[0031] Figure 6 is the present invention Figure 5 partial enlarged view of part C.

[0032] Figure 7 is a three-dimensional installation structural schematic diagram between the rotating shaft, the second gear, the third gear and the like of the present invention.

[0033] Figure 8 This is the flow chart of the sampling method for HPV detection and screening in the present invention.

[0034] Explanation of the reference numerals: 1. Sampling tube; 11. Stirring frame; 12. Stirring rod; 13. Gear teeth; 14. Fixed protrusion; 15. Rotating shaft; 16. First gear; 17. Second gear; 18. Third gear; 2. Rotating rod; 21. Sleeve rod; 22. Linking ring; 23. Limiting rod; 24. Annular plate; 25. Arc-shaped protrusion; 26. Linking rod; 3. Sampling brush; 4. Cleaning mechanism; 41. Reciprocating plate; 42. Connecting rod. Detailed implementation manners

[0035] The following further elaborates on this application Figures 1 to 8 in conjunction with the attached drawings.

[0036] The embodiments of this application disclose a sampling device and method for HPV detection and screening. By changing the movement mode of the sampling brush and the state of the water flow, the exfoliated cells adhered to the surface of the sampling brush are thoroughly washed in different forms to ensure the concentration of the exfoliated cells in the solution.

[0037] Referring to Figure 1 and Figure 2 , a sampling device for HPV detection and screening includes a sampling tube 1 with an opening at the bottom. The top of the sampling tube 1 is rotatably installed through a bearing with a rotating rod 2. The top of the rotating rod 2 is provided with a sampling brush 3. The sampling tube 1 is also provided with a cleaning mechanism 4 for scraping the exfoliated cells attached to the surface of the sampling brush 3.

[0038] The cleaning mechanism 4 includes: a reciprocating plate 41, which is limited and slidably arranged on the inner wall of the sampling tube 1, and the rotating rod 2 passes through the reciprocating plate 41.

[0039] The rotating rod 2 is provided with a double-thread that cooperates with the reciprocating plate 41.

[0040] Connecting rods 42 are symmetrically arranged along the length direction of the reciprocating plate 41. The bottoms of the connecting rods 42 are jointly installed with an annular scraping plate 43, and the annular scraping plate 43 is coaxial with the rotating rod 2.

[0041] During the rotation of the rotating rod 2, the exfoliated cells adhered to the sampling brush 3 are thrown into the solution by inertia. In the cleaning mechanism 4, during the up-and-down reciprocating movement of the reciprocating plate 41, the annular scraping plate 43 is driven to move up and down through the connecting rods 42. During the reciprocating movement of the annular scraping plate 43, the exfoliated cells adhered to the sampling brush 3 can be scraped off and fall into the solution, thereby ensuring that the exfoliated cells adhered to the sampling brush 3 can be washed into the solution as much as possible, ensuring the concentration of the solution, and avoiding the influence of low solution concentration on the subsequent detection effect.

[0042] Reference Figure 4 A sleeve rod 21 that reciprocates along its length is provided with a limit sliding sleeve at the bottom of the circumferential surface of the rotating rod 2, and is detachably installed at the bottom of the sleeve rod 21.

[0043] A spring clip (which is a prior art and thus not shown in the figure) is provided at the bottom of the sleeve rod 21. Then, the solution for extracting exfoliated cells is filled into an existing beaker. During specific operation, the sampling brush 3 with exfoliated cells adhered after sampling is moved to the bottom of the sleeve rod 21, and the existing spring clip is used to clamp the sampling brush 3. Then, the sampling tube 1 with the sampling brush 3 installed is moved to the beaker filled with the solution, and the sampling tube 1 is fixed on the inner wall of the beaker, and the sampling brush 3 is immersed in the solution.

[0044] At this time, the rotating rod 2 is driven to rotate by an external drive motor (not shown in the figure). During the rotation of the rotating rod 2, the sampling brush 3 is driven to rotate by the sleeve rod 21. During the rotation of the sampling brush 3, the exfoliated cells adhered to the sampling brush 3 are thrown into the solution by inertia.

[0045] Meanwhile, during the rotation of the rotating rod 2, the reciprocating plate 41 is synchronously driven to reciprocate up and down along the rotating rod 2 through a bidirectional thread. During the up and down reciprocating movement of the reciprocating plate 41, the annular scraping plate 43 is driven to reciprocate up and down by the connecting rod 42. It should be noted that the inner diameter of the annular scraping plate 43 is slightly smaller than the diameter of the sampling brush 3. During the up and down reciprocating movement of the annular scraping plate 43, the inner wall thereof can scrape the exfoliated cells adhered to the surface of the sampling brush 3, and the scraped exfoliated cells fall into the solution.

[0046] Furthermore, by the cooperation of the inertia of the rotation of the sampling brush 3 and the reciprocating scraping of the annular scraping plate 43, the exfoliated cells adhered to the surface of the sampling brush 3 can be washed into the solution, ensuring the concentration of the solution and avoiding the influence of low solution concentration on the subsequent detection effect.

[0047] Reference Figure 3 And Figure 4 In order to further improve the washing effect of the exfoliated cells on the surface of the sampling brush 3, the linkage ring 22 provided by the present invention can shake off the exfoliated cells on the surface of the sampling brush 3 through the cooperation of the linkage rod 26 and the arc-shaped protrusion 25. Specifically, the circumferential surface of the sleeve rod 21 is provided with a linkage ring 22. The circumferential surface of the linkage ring 22 is symmetrically provided with limit rods 23 along the width direction of the reciprocating plate 41. One end of the limit rod 23 away from the linkage ring 22 is slidably arranged on the inner wall of the sampling tube 1.

[0048] An annular plate 24 that cooperates with the linkage ring 22 is installed on the rotating rod 2. A plurality of arc-shaped protrusions 25 are evenly arranged along the circumferential direction on the top of the annular plate 24. A linkage rod 26 is arranged on the linkage ring 22, and one end of the linkage rod 26 away from the linkage ring 22 cooperates with the arc-shaped protrusion 25.

[0049] The above-mentioned limiting rod 23 can limit the linkage ring 22 during the rotation of the rotating rod 2, ensuring that the linkage ring 22 will not rotate synchronously with the rotating rod 2 during the rotation of the rotating rod 2. During specific operation, when the rotating rod 2 rotates, it drives the annular plate 24 to rotate synchronously. During the rotation of the annular plate 24, the arc-shaped protrusion 25 rotates circumferentially synchronously. When the arc-shaped protrusion 25 contacts the linkage rod 26, the arc-shaped protrusion 25 drives the linkage ring 22 to move upward a certain distance through the linkage rod 26. At this time, during the upward movement of the linkage ring 22, the sleeve rod 21 is driven to move upward synchronously. When the linkage rod 26 moves out of the arc-shaped protrusion 25, the linkage ring 22 resets synchronously. Repeating the above actions, that is, the linkage ring 22 can drive the sampling brush 3 to vibrate up and down reciprocally through the mutual cooperation of the linkage rod 26 and the arc-shaped protrusion 25. That is, through the above steps, the exfoliated cells on the sampling brush 3 can be shaken off, further ensuring that the exfoliated cells adhered to the sampling brush 3 can be washed into the solution.

[0050] Furthermore, while the exfoliated cells adhered to the surface of the sampling brush 3 are shaken off by the inertia of the rotation of the sampling brush 3 and the reciprocating scraping of the annular scraper 43, the exfoliated cells adhered to the surface of the sampling brush 3 can also be shaken off by vibrating the sampling brush 3, more thoroughly washing the exfoliated cells adhered to the sampling brush 3 into the solution.

[0051] Refer to Figure 5 , in addition to changing the movement mode of the sampling brush 3, the exfoliated cells on the surface of the sampling brush 3 can also be further washed by changing the state of the external water flow. Specifically, a stirring frame 11 is rotatably arranged at the bottom of the circumferential surface of the sampling tube 1, and a plurality of stirring rods 12 are uniformly arranged along the circumferential direction at the bottom of the stirring frame 11.

[0052] During specific operation, during the process of washing the sampling brush 3, the stirring frame 11 is driven to rotate by an external driving force. During the rotation of the stirring frame 11, the stirring rods 12 are driven to rotate. During the rotation of the stirring rods 12, the solution can be driven to form a water flow, and then the water flow rotates to form a vortex. Thus, the vortex can wash the exfoliated cells adhered to the surface of the sampling brush 3, causing the exfoliated cells adhered to the surface of the sampling brush 3 to be subjected to an external force. Finally, the exfoliated cells adhered to the surface of the sampling brush 3 fall off from the sampling brush 3, ensuring the washing effect of the sampling brush 3.

[0053] In order to ensure that the vortex force near the sampling brush 3 is large enough, the stirring rods 12 provided in the present invention are arranged close enough to the sampling brush 3. Specifically, the stirring rods 12 are arranged in a bent structure with two vertical sections and one horizontal section. The vertical section of the stirring rod 12 far from the rotating rod 2 is installed on the stirring frame 11, and the vertical section of the stirring rod 12 close to the rotating rod 2 is close to the sampling brush 3.

[0054] During specific operation, when the stirring rod 12 rotates, the end of the stirring rod 12 away from the stirring frame 11 approaches the sampling brush 3. Therefore, during the rotation of the end of the stirring rod 12 away from the teaching edition, sufficient eddy current resistance can be given to the sampling brush 3, further ensuring that the exfoliated cells adhered to the surface of the sampling brush 3 can smoothly fall off from the sampling brush 3.

[0055] Refer to Figure 6 and Figure 7 , in order to reduce the use of external drive, the present invention provides that the rotating shaft 15 and the rotating rod 2 cooperate with each other to provide driving force for the rotation of the stirring frame 11. Specifically, a plurality of gear teeth 13 are uniformly arranged on the circumferential surface of the stirring frame 11 along its circumferential direction, and a fixed protrusion 14 is arranged on the circumferential surface of the sampling tube 1 (refer to Figure 2 ), and a rotating shaft 15 extending along the length direction of the sampling tube 1 is rotatably installed through the fixed protrusion 14 by means of a bearing, and a first gear 16 meshing with the gear teeth 13 is installed at the bottom of the circumferential surface of the rotating shaft 15.

[0056] A second gear 17 is installed at the top of the circumferential surface of the rotating shaft 15, and a third gear 18 meshing with the second gear 17 is installed at the top of the circumferential surface of the rotating rod 2.

[0057] During specific operation, during the rotation of the rotating rod 2, the rotating shaft 15 is driven to rotate through the cooperation of the third gear 18 and the second gear 17. During the rotation of the rotating shaft 15, the first gear 16 is driven to rotate. During the rotation of the first gear 16, it meshes with the gear teeth 13 to drive the stirring frame 11 to rotate. During the rotation of the stirring frame 11, it can drive the stirring rod 12 to rotate without other external driving forces, that is, only through the driving force provided by the rotation of the rotating rod 2.

[0058] The solution obtained through the above steps contains exfoliated cells, and then the solution to be detected is aspirated by an existing dropper for subsequent detection preparation.

[0059] Finally, refer to Figure 8 , the present invention also provides a sampling method for HPV detection and screening, and its usage method includes the following steps: S1: Sampling treatment, using the sampling brush 3 to dip into human exfoliated cells to obtain a sample.

[0060] S2: Installation treatment, move the sampling brush 3 with exfoliated cells adhered after sampling to the bottom of the sleeve rod 21, and use an existing spring clip to clamp the sampling brush 3. Then move the sampling tube 1 with the sampling brush 3 installed into a beaker filled with solution, and fix the sampling tube 1 on the inner wall of the beaker, and make the sampling brush 3 immersed in the solution.

[0061] S3: Washing process. During the rotation of the rotating rod 2, the sampling brush 3 is driven to rotate through the sleeve rod 21. During the rotation of the sampling brush 3, the exfoliated cells adhered to the sampling brush 3 are thrown off into the solution by inertia. In addition, during the rotation of the rotating rod 2, the reciprocating plate 41 is synchronously driven to move up and down along the rotating rod 2 through the double-thread. During the up-and-down reciprocating movement of the reciprocating plate 41, the annular scraper 43 is driven to move up and down through the connecting rod 42. During the up-and-down reciprocating movement of the annular scraper 43, the inner wall thereof can scrape off the exfoliated cells adhered to the surface of the sampling brush 3.

[0062] S4: Absorb the solution. Then, use an existing rubber dropper to absorb the solution to be detected to prepare for subsequent detection.

[0063] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention. Any reference signs in the claims should not be regarded as limiting the claims involved.

[0064] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A sampling device for HPV detection and screening, comprising a sampling tube (1) with an opening at the bottom, characterized in that: The top of the sampling tube (1) is rotatably mounted with a rotating rod (2) passing through a bearing, and a sampling brush (3) is arranged at the top of the rotating rod (2). The sampling tube (1) is also provided with a cleaning mechanism (4) for scraping off the exfoliated cells attached to the surface of the sampling brush (3), wherein: The cleaning mechanism (4) comprises: A reciprocating plate (41) is limitedly slidably arranged on the inner wall of the sampling tube (1), and the rotating rod (2) passes through the reciprocating plate (41); The connecting rod (42) is symmetrically arranged along the length direction of the reciprocating plate (41), and an annular scraper (43) is installed at the bottom of the connecting rod (42), and the annular scraper (43) is coaxial with the rotating rod (2).

2. A sampling device for HPV detection and screening according to claim 1, characterized in that: The rotating rod (2) is provided with a bidirectional thread matched with the reciprocating plate (41).

3. A sampling device for HPV detection and screening according to claim 1, characterized in that: The limiting sliding sleeve at the bottom of the circumferential surface of the rotating rod (2) is provided with a sleeve rod (21) which reciprocates along its length direction and is detachably mounted at the bottom of the sleeve rod (21).

4. A sampling device for HPV detection and screening according to claim 3, characterized in that: The sleeve rod (21) is provided with a linkage ring (22) on its circumferential surface, and a limit rod (23) is symmetrically provided on the circumferential surface of the linkage ring (22) along the width direction of the reciprocating plate (41), and one end of the limit rod (23) away from the linkage ring (22) is slidably provided on the inner wall of the sampling tube (1).

5. A sampling device for HPV detection and screening according to claim 4, characterized in that: The rotating rod (2) is provided with an annular plate (24) matched with the linkage ring (22), a plurality of arc-shaped protrusions (25) are evenly arranged on the top of the annular plate (24) along its circumference, a linkage rod (26) is arranged on the linkage ring (22), and one end of the linkage rod (26) away from the linkage ring (22) is matched with the arc-shaped protrusion (25).

6. The HPV detection and screening sampling device according to claim 1, characterized in that: A stirring frame (11) is rotatably arranged at the bottom of the circumferential surface of the sampling tube (1), and a plurality of stirring rods (12) are evenly arranged at the bottom of the stirring frame (11) along its circumference.

7. A sampling device for HPV detection and screening according to claim 6, characterized in that: The stirring rod (12) is configured as a bent structure with two vertical sections and one horizontal section. The vertical section of the stirring rod (12) away from the rotating rod (2) is installed on the stirring frame (11), and the vertical section of the stirring rod (12) close to the rotating rod (2) is close to the sampling brush (3).

8. The HPV detection and screening sampling device according to claim 1, characterized in that: The circumferential surface of the stirring frame (11) is evenly provided with a plurality of gear teeth (13) along its circumference, and the circumferential surface of the sampling tube (1) is provided with a fixing protrusion (14), and a rotating shaft (15) extending along the length direction of the sampling tube (1) is rotatably installed on the fixing protrusion (14) through a bearing, and a gear (16) meshing with the gear teeth (13) is installed at the bottom of the circumferential surface of the rotating shaft (15).

9. A sampling device for HPV detection and screening according to claim 8, characterized in that: A second gear (17) is installed at the top of the circumferential surface of the rotating shaft (15), and a third gear (18) meshing with the second gear (17) is installed at the top of the circumferential surface of the rotating rod (2).

10. A sampling method for HPV detection and screening, comprising a sampling device for HPV detection and screening according to any one of claims 1 to 9, characterized in that: The method of use includes the following steps: S1: Sampling and processing, using a sampling brush (3) to dip human exfoliated cells to obtain a sample; S2: Installation process, clamping the sampling brush (3) dipped with the sample to the bottom of the sleeve rod (21); S3: washing treatment, washing the sampling brush (3) to obtain a solution to be tested; S4: Aspirate the solution, and then aspirate the solution to be tested in preparation for subsequent testing.

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