Efficient whitening composition as well as preparation and application thereof

Abstract

The invention relates to an efficient whitening composition as well as a preparation method and application thereof. The whitening composition is prepared from dimethyl methoxy chromanol, calcium panthenyl mercaptoethylamine sulfonate and hydroxytyrosol, and specifically, the whitening composition is prepared from the following components in percentage by mass: 0.1 percent to 20 percent of dimethyl methoxy chromanol, 0.1 percent to 20 percent of calcium panthenyl mercaptoethylamine sulfonate, 0.1 percent to 10 percent of hydroxytyrosol and the balance of an oil solvent. According to the invention, several reasonably screened components which can be degraded by skin and absorbed transdermally and supply nutrition to the skin are reasonably combined, and all the components achieve a synergistic effect, so that the prepared matrix has the effect of whitening the skin. The matrix is added into cosmetic formulas such as toning lotion, emulsion and cream, and the efficacy of cosmetics can be remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and particularly relates to a highly efficient whitening composition and its preparation and application. Background Art

[0002] The color of human skin is determined by the joint participation of multiple pigments, among which the most important one is melanin. Melanin plays an important role in preventing ultraviolet radiation and protecting the deep tissues of the skin. However, too much melanin will make the skin look dark and affect beauty.

[0003] Ultraviolet rays are an important factor leading to melanin deposition and affecting skin color, and the key to melanin production is tyrosinase. Therefore, reducing the production of tyrosinase or reducing the activity of tyrosinase is an important way to achieve whitening.

[0004] The existing whitening cosmetics usually take 28 days as a whitening cycle, and it is very rare to achieve a highly efficient whitening and freckle-removing effect within 7 - 10 days. The long whitening cycle of the existing whitening cosmetics means that consumers cannot obtain a quick whitening experience in a timely manner, resulting in the products not being quickly recognized, which is not conducive to the promotion of the products. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a highly efficient whitening composition. Through the mutual cooperation and synergistic effect of multiple whitening components, it can efficiently reduce the production of melanin, brighten the skin color, reduce melanin synthesis, and has an excellent freckle-removing effect.

[0006] The technical solution adopted by the present invention is as follows:

[0007] A highly efficient whitening composition, which includes: dimethylmethoxy chromanol, calcium pantothenyl mercaptoethyl sulfonate, and hydroxytyrosol. All three components belong to chemical whitening agents. The present invention uses this combination of whitening agents to prepare various dosage forms of cosmetics. Through detection, the cosmetics containing this composition have a significant whitening and freckle-removing effect.

[0008] The highly efficient whitening composition of the present invention includes the components shown in the following table:

[0009] Composition Manufacturer Combined ratio (wt%) Dimethylmethoxy chromanol Lubrizol Advanced Materials 0.1％～20％ Calcium pantothenylcysteine sulfonate Sogo Pharmaceutical Co., Ltd. 0.1％～20％ Hydroxytyrosol Hangzhou Viprobe Biotechnology Co., Ltd. 0.1％～10％ Oil solvent The balance

[0010] Among them, the preferred ratio of dimethylmethoxy chromanol is 10 wt%, the preferred ratio of calcium pantothenyl mercaptoethyl sulfonate is 5 wt%, and the preferred ratio of hydroxytyrosol is 5 wt%.

[0011] The preparation method of the highly efficient whitening composition of the present invention includes the following steps:

[0012] It is obtained by heating and dissolving dimethylmethoxy chromanol, calcium pantothenylcysteine sulfonate, hydroxytyrosol and an oil solvent together, keeping the temperature, and then cooling down.

[0013] Preferably, the heating and dissolving temperature is 50-90 °C, the heat preservation time is 30 min, and after heat preservation, it is cooled down to normal temperature (25 °C room temperature) to obtain a homogeneous liquid.

[0014] The high-efficiency whitening composition of the present invention can be used to prepare cosmetics for whitening the skin.

[0015] The whitening cosmetics of the present invention comprise the following components in mass percentage:

[0016] Component A: glycerol 3.0-5.0%, phenoxyethanol 0.5-1%, carbomer 0.1-0.2%;

[0017] Component B: polyglyceryl-3 methylglucose distearate 1-2%, the above high-efficiency whitening composition 10-20%;

[0018] Component C: triethanolamine 0.1-0.2%;

[0019] Component D: deionized water the balance.

[0020] The preparation method of the whitening cosmetics of the present invention is as follows: After mixing Component A, Component B, and Component C, it is supplemented with deionized water to 100% to obtain.

[0021] The advantages of the present invention are reflected in:

[0022] In the present invention, several components that can supply nutrients to the skin are reasonably selected and combined rationally, and a synergistic effect is achieved among the components, so that the prepared matrix has the effect of whitening the skin. Adding the above matrix to the formula of cosmetics such as lotion and cream can significantly improve the efficacy of the cosmetics. Specific Embodiments

[0023] To enable those skilled in the art to understand the present invention more clearly and intuitively, the present invention will be further described below. The experimental methods without specific conditions in the following examples are carried out according to conventional methods and conditions, or selected according to the product specifications.

[0024] Matrix 1: Comprises the following components in mass percentage:

[0025] 10% dimethylmethoxy chromanol, 5% calcium pantothenylcysteine sulfonate, 5% hydroxytyrosol, 80% pentaerythritol tetra(ethylhexanoate) (oil solvent).

[0026] Matrix 2: Comprises the following components in mass percentage:

[0027] 10% Dimethylmethoxy Chroman-4-ol and 90% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0028] Matrix 3: Comprising the following components in mass percentage:

[0029] 5% Calcium Pantethionate Sulfonate and 95% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0030] Matrix 4: Comprising the following components in mass percentage:

[0031] 5% Hydroxytyrosol and 95% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0032] Matrix 5: Comprising the following components in mass percentage:

[0033] 10% Dimethylmethoxy Chroman-4-ol, 5% Calcium Pantethionate Sulfonate and 85% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0034] Matrix 6: Comprising the following components in mass percentage:

[0035] 10% Dimethylmethoxy Chroman-4-ol, 5% Hydroxytyrosol and 85% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0036] Matrix 7: Comprising the following components in mass percentage:

[0037] 5% Calcium Pantethionate Sulfonate, 5% Hydroxytyrosol and 90% Pentaerythrityl Tetra(ethylhexanoate) (oil solvent).

[0038] The matrix is made into a whitening cream and the whitening effect is tested.

[0039] Test method: The tester applies the whitening cream 2 times a day, and the facial ITA value is measured on day 0 and day 7 to evaluate the whitening effect of the matrix.

[0040] Test instrument: VISIA Skin Imaging System.

[0041] The ITA value is analyzed by Image-Pro Plus image analysis software.

[0042] Example 1

[0043] The whitening cream of this example comprises the following components in mass percentage:

[0044] Glycerin 4%, Phenoxyethanol 0.8%, Carbomer 0.15%, Polyglyceryl-3 Methylglucose Distearate 1.5%, Matrix 1 10%, Triethanolamine 0.15%, the balance being deionized water.

[0045] According to the dosage requirements, mix glycerin, phenoxyethanol, carbomer, polyglyceryl-3 methylglucose distearate, matrix 1, and triethanolamine, and then make up to 100% with deionized water to obtain it.

[0046] Example 2

[0047] The difference between the whitening cream of this example and that of Example 1 is that the addition amount of matrix 1 is 15%.

[0048] Example 3

[0049] The difference between the whitening cream of this example and that of Example 1 is that the addition amount of matrix 1 is 20%.

[0050] Comparative Example 1

[0051] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 2, and the addition amount remains unchanged at 20%.

[0052] Comparative Example 2

[0053] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 3, and the addition amount remains unchanged at 20%.

[0054] Comparative Example 3

[0055] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 4, and the addition amount remains unchanged at 20%.

[0056] Comparative Example 4

[0057] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 5, and the addition amount remains unchanged at 20%.

[0058] Comparative Example 5

[0059] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 6, and the addition amount remains unchanged at 20%.

[0060] Comparative Example 6

[0061] The difference between the whitening cream of this comparative example and that of Example 3 is that matrix 1 is replaced with matrix 7, and the addition amount remains unchanged at 20%.

[0062] Experimental data

[0063] Whitening test results of Example 1 (10% matrix 1)

[0064]

[0065]

[0066] Whitening test results of Example 2 (15% Matrix 1)

[0067] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 54.462 63.104 15.87％ Tester 2 54.122 62.450 15.39％ Tester 3 56.275 64.665 14.91％ Tester 4 56.085 65.326 16.48％ Tester 5 57.420 67.042 16.76％ Tester 6 56.360 65.146 15.59％ Tester 7 57.450 66.534 15.81％ Tester 8 58.120 66.804 14.94％ Tester 9 56.850 64.875 14.12％ Tester 10 56.136 65.215 16.17％ Average value 56.328 65.1161 15.60％

[0068] Whitening test results of Example 3 (20% Matrix 1)

[0069]

[0070]

[0071] Whitening test results of Comparative Example 1 (20% Matrix 2)

[0072] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 55.756 58.584 5.07％ Tester 2 54.255 57.353 5.71％ Tester 3 56.655 59.215 4.52％ Tester 4 57.025 59.860 4.97％ Tester 5 55.358 58.036 4.84％ Average value 55.810 58.610 5.02％

[0073] Whitening test results of Comparative Example 2 (20% Matrix 3)

[0074] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 57.453 59.515 3.59％ Tester 2 56.354 57.865 2.68％ Tester 3 55.785 57.114 2.38％ Tester 4 56.414 58.230 3.22％ Tester 5 55.645 56.940 2.33％ Average value 56.330 57.933 2.84％

[0075] Whitening test results of Comparative Example 3 (20% Matrix 4)

[0076]

[0077]

[0078] Whitening test results of Comparative Example 4 (20% Matrix 5)

[0079] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 58.024 61.655 6.26％ Tester 2 56.347 60.456 7.29％ Tester 3 55.475 59.652 7.53％ Tester 4 57.346 61.326 6.94％ Tester 5 58.045 61.754 6.39％ Average value 57.047 60.969 6.88％

[0080] Whitening test results of Comparative Example 5 (20% Matrix 6)

[0081] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 57.456 60.384 5.10％ Tester 2 56.955 60.636 6.46％ Tester 3 55.685 59.043 6.03％ Tester 4 56.023 59.330 5.90％ Tester 5 56.844 59.682 4.99％ Average value 56.593 59.815 5.70％

[0082] Whitening test results of Comparative Example 6 (20% Matrix 7)

[0083] D0 (ITA value) D7 (ITA value) 7-day change rate Tester 1 57.655 61.785 7.16％ Tester 2 56.440 60.665 7.49％ Tester 3 56.986 60.346 5.90％ Tester 4 57.085 60.876 6.64％ Tester 5 57.144 60.545 5.95％ Average value 57.062 60.843 6.63％

[0084] Data conclusion:

[0085] Examples 1 - 3 (with 3 whitening ingredients) can significantly improve the skin whitening effect within 7 days, and the whitening effect is more significant with the increase of the addition amount; the change rate of Comparative Examples 1 - 6 (with 1 or 2 whitening ingredients) is not significant within 7 days, and the ideal whitening effect cannot be achieved. Therefore, preparing a whitening product with a matrix containing three whitening ingredients can not only significantly increase the ITA value of facial skin, but also shorten the time for testing the whitening effect, realizing that the whitening cosmetics can complete the effect verification in 7 - 10 days. For consumers, they can obtain the whitening experience in a timely and rapid manner, and the product can be quickly recognized, thus facilitating the promotion of the product.

[0086] The above description of the embodiments is provided to enable those of ordinary skill in the art to understand and apply the present invention. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative efforts. Therefore, the present invention is not limited to the embodiments herein, and all improvements and modifications made by those skilled in the art based on the disclosure of the present invention should fall within the protection scope of the present invention.

Claims

1. A highly effective whitening composition, characterized in that: The whitening composition comprises: dimethylmethoxybenzodihydropyranol, calcium pantetheine sulfonate and hydroxytyrosol.

2. The high-efficiency whitening composition according to claim 1, characterized in that: The whitening composition comprises the following components in percentage by weight: 0.1% to 20% of dimethylmethoxychromanol, 0.1% to 20% of calcium pantetheine sulfonate, 0.1% to 10% of hydroxytyrosol, and the balance of oil solvent.

3. The high-efficiency whitening composition according to claim 1, characterized in that: The whitening composition comprises the following components in percentage by weight: 10% of dimethylmethoxychromanol, 5% of calcium pantetheine sulfonate, 5% of hydroxytyrosol, and the balance of oil solvent.

4. The high-efficiency whitening composition according to claim 2 or 3, characterized in that: The oil solvent is pentaerythritol tetra(ethylhexanoate).

5. The method for preparing the high-efficiency whitening composition according to claim 2 or 3, characterized in that: The steps include: Dimethylmethoxybenzodihydropyranol, calcium pantethine sulfonate, hydroxytyrosol and an oil solvent are heated together to dissolve, and then the temperature is reduced after the temperature is kept to obtain the product.

6. The method for preparing the high-efficiency whitening composition according to claim 5, characterized in that: The heating and dissolving temperature is 50-90°C, the insulation time is 30 minutes, and then the temperature is lowered to room temperature to obtain a uniform liquid.

7. The method for preparing the high-efficiency whitening composition according to claim 5, characterized in that: The oil solvent is pentaerythritol tetra(ethylhexanoate).

8. Use of the high-efficiency whitening composition as claimed in claim 1, 2 or 3 in the preparation of whitening skin care products.

9. A whitening skin care product, characterized in that: The invention comprises the high-efficiency whitening composition as claimed in claim 1, 2 or 3.

10. The whitening skin care product according to claim 9, characterized in that: The composition includes the following components in percentage by mass: Component A: glycerin 3.0-5.0%, phenoxyethanol 0.5-1%, carbomer 0.1-0.2%; Component B: 1-2% polyglyceryl-3 methyl glucose distearate, 10-20% high-efficiency whitening composition; Component C: triethanolamine 0.1-0.2%; Component D: balance deionized water.

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