Composition with lung moistening and cough relieving functions and preparation method thereof
By using a combination of Chinese medicinal materials such as concentrated pear juice and auxiliary materials, the composition made can effectively moisten the lungs and relieve cough, solve the problems of side effects of traditional Chinese and Western medicines and poor functional food effects, and achieve efficient and safe lung conditioning effects.
Patent Information
- Application Number
- CN202411456615.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-18
- Publication Date
- 2025-05-30
AI Technical Summary
In the prior art, Western medicine has side effects when treating respiratory symptoms caused by accumulation of cold and dampness in the lungs, and functional foods have poor conditioning effects, making it difficult to achieve ideal improvement effects.
A composition is adopted, including concentrated Chinese medicinal materials such as pear juice, lily, purpura, Luohan fruit, Polygonatum, loquat leaves, rock sugar, etc., and additives such as oligoisomaltosol, fructose, glycerin, etc., to make tablets, granules, pills or oral liquids.
This composition can effectively moisturize the lungs and relieve cough, improve palatability, and ensure food safety. By combining heat and cold and neutralizing medicinal properties, it can relieve and improve the symptoms of lung heat and cough to the greatest extent, and avoid defects and sequelae caused by drug conflicts.
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Abstract
Description
Technical Field
[0001] The present invention relates to the field of traditional Chinese medicine, and specifically relates to a composition with the function of moistening the lungs and relieving cough and its preparation method. Background Art
[0002] According to traditional Chinese medicine theory, the accumulation of cold-dampness in the lungs can induce a series of respiratory symptoms, including but not limited to cough, asthma, sore throat, increased sputum, and a feeling of foreign body in the throat. In modern life, due to irregular work and rest habits, preference for cold drinks, frequent staying up late, and lack of appropriate exercise, coupled with the climate change brought about by the change of seasons, the human body is more vulnerable to the invasion of cold-dampness. The long-term accumulation of cold-dampness may weaken the lung qi, thereby triggering the above symptoms.
[0003] Although Western medicine has the characteristic of quick effect in relieving cough, its accompanying side effects cannot be ignored. At the same time, although functional foods on the market are sold with the selling points of safety and no side effects, their conditioning effects are often unsatisfactory and it is difficult to achieve the ideal improvement effect. Summary of the Invention
[0004] The first technical object of the present invention is to solve the problems in the background art and provide a composition with the function of moistening the lungs and relieving cough.
[0005] The second technical object of the present invention is to provide a preparation method of a composition with the function of moistening the lungs and relieving cough.
[0006] The first technical object of the present invention is achieved through the following technical solutions: A composition with the function of moistening the lungs and relieving cough, comprising active ingredient main raw materials and post-treatment auxiliary materials; the main raw materials include 60-90 parts of concentrated pear juice, 3-8 parts of lily, 3-8 parts of polygonatum odoratum, 2-6 parts of momordica grosvenori, 2-6 parts of polygonatum sibiricum, 2-6 parts of eriobotrya japonica leaves, and 2-4 parts of rock sugar; the auxiliary materials include isomaltooligosaccharide, fructooligosaccharide, glycerol, inulin, pectin, xanthan gum, locust bean gum, and citric acid, and the dosage form of the traditional Chinese medicine composition is tablets, granules, pills, syrups, and oral liquids.
[0007] Preferably, the active ingredient main raw materials further include 3-8 parts of apricot kernels, 2-6 parts of sterculia lychnophora, 2-4 parts of honeysuckle, 2-4 parts of platycodon grandiflorum, 2-4 parts of chrysanthemum, 2-4 parts of tangerine peel, and 2-4 parts of Chinese dates.
[0008] Preferably, the active ingredients in the main raw materials further include 0.5-2 parts of belamcanda chinensis and scutellaria baicalensis extract, 1-3 parts of anemarrhena asphodeloides, 1-3 parts of gnaphalium affine, 0.1-1.2 parts of morinda officinalis, and 0.5-1 part of bovine lung peptide.
[0009] Preferably, the main raw materials include 80 - 90 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 5 parts of momordica grosvenori, 3 parts of polygonatum sibiricum, 7 parts of eriobotrya japonica leaf, 2 parts of rock candy, 5 parts of almond, 3 parts of sterculia lychnophora, 3 parts of honeysuckle, 5 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 0.5 - 2 parts of the extract of belamcanda chinensis and scutellaria baicalensis, 1 - 3 parts of anemarrhena asphodeloides, 1 - 3 parts of gnaphalium affine, and 0.5 - 1 part of bovine lung peptide, where the parts by mass are not calculated based on 100 parts.
[0010] Adopting the present invention, the advantage is that the concentrated pear juice accounts for the majority in the active main raw materials, carrying lily, eriobotrya japonica leaf, polygonatum odoratum, etc., and supplemented with rock candy. Whether it is made into a liquid oral liquid, syrup, or solid pill, granule, or tablet, it can improve the palatability of the medicine and maintain the function of moistening the lungs and relieving cough on the basis of improving the palatability.
[0011] Adopting the present invention, the advantage is that momordica grosvenori is also added to the main raw materials, and it is combined with almond, sterculia lychnophora, honeysuckle, platycodon grandiflorum, chrysanthemum, dried tangerine peel, Chinese date, and anemarrhena asphodeloides; momordica grosvenori is cold in nature, sweet in taste and can clear the lung and reduce phlegm; almond is slightly warm in nature and will not have too obvious an impact on the balance of yin and yang in the human body, being suitable for most people to consume; sterculia lychnophora is sweet in taste and cool in nature, entering the lung and large intestine meridians, having the effects of clearing lung heat, benefiting the throat, detoxifying, and laxative, promoting fluid production to quench thirst, and relieving sore throat and hoarseness, being used for hoarseness due to lung heat and sore throat; honeysuckle is sweet in taste and cold in nature, having the functions of clearing heat and detoxifying, and dispersing wind-heat; platycodon grandiflorum is neither hot nor cold, pungent and bitter in taste, neutral in nature, belonging to the lung meridian, having the effects of dispersing the lung qi, reducing phlegm, benefiting the throat, and expelling pus; chrysanthemum is slightly cold in nature and belongs to the traditional Chinese medicine for dispersing wind-heat, having the effects of dispersing wind-heat and clearing liver fire; dried tangerine peel is warm in nature and has high medicinal and edible values; Chinese date is sweet in taste and warm in nature, belonging to the spleen and stomach meridians, having the functions of invigorating the middle qi, nourishing blood and calming the mind, and alleviating the properties of other drugs, and containing rich nutritional components such as protein, fat, carbohydrates, organic acids, vitamin A, vitamin C, various trace elements of calcium, and amino acids; anemarrhena asphodeloides is cold in nature, bitter and sweet in taste, cold in nature, being the dried rhizome of anemarrhena asphodeloides, a plant of the genus anemarrhena in the liliaceae family, having the effects of clearing heat and purging fire, and nourishing yin and moistening dryness. It is mainly used for fever with restlessness and cough due to dryness of the lung. Combining the above traditional Chinese medicine raw materials with warm and cold properties in an appropriate proportion can fully exert the functions of clearing heat and purging fire of the above medicinal materials and achieve a better effect of moistening the lungs and relieving cough.
[0012] Adopting the present invention, the advantage lies in the Chuan Shegan Scutellaria baicalensis extract of the active ingredient, that is, the flavonoid extract extracted therefrom. Modern research shows that the main active ingredients of Scutellaria baicalensis are flavonoid components mainly including baicalin, wogonoside, baicalein, and wogonin, while the main active ingredients of Belamcanda chinensis are isoflavonoid chemical components mainly including tectoridin, iridin, tectorigenin, irigenin, and irilone. The main active ingredients of Belamcanda chinensis and Scutellaria baicalensis are both flavonoid compounds, and their main pharmacological activities are all anti-inflammatory, antibacterial, antiviral, antipyretic, analgesic, antitussive, etc. Moreover, the yield of the flavonoid extract obtained by extracting the flavonoid extract from Chuan Shegan and Scutellaria baicalensis is significantly higher than that obtained by separately extracting the same amount of Chuan Shegan or Scutellaria baicalensis; adding the Chuan Shegan Scutellaria baicalensis flavonoid extract to the raw materials can save the cost of extracting flavonoids, and the contained flavonoid extract can also enhance the effect of moistening the lungs and relieving cough.
[0013] Adopting the present invention, the advantage lies in that Gnaphalium affine has the effect of resolving phlegm and relieving cough, and can be applied to both cold cough and heat cough.
[0014] Adopting the present invention, the advantage lies in that Morinda officinalis oligosaccharide (MOO) is one of the main active ingredients of Morinda officinalis. As a naturally occurring plant oligosaccharide, MOO has various pharmaceutical applications. MOO plays a role in inhibiting and relieving lung inflammation symptoms, can reduce pathological damage and the expression of pro-inflammatory cytokines.
[0015] Adopting the present invention, the advantage lies in that through the monarch-minister combination of bovine lung peptide, Lily bulb, and Polygonatum odoratum, the effect of moistening the lungs and relieving cough of the composition is greatly improved. Bovine lung peptide contains various proteins, amino acids, and minerals, and can help improve lung function through the regulatory effect on bronchial mucosa, so as to normalize its metabolism and enhance its function. At the same time, it has a harmonizing and reducing effect on the toxicity and cold nature of the Lily bulb extract. The Polygonatum odoratum extract contains rich dietary fiber. The compatibility of the dietary fiber in the Polygonatum odoratum extract, bovine lung peptide, and Lily bulb extract not only improves the effect of moistening the lungs and relieving cough of the composition, but also reduces the toxicity and cold nature of the Lily bulb.
[0016] Adopting the present invention, the advantage lies in that through the material combination in the present invention scheme, not only can a good effect of moistening the lungs and relieving cough be achieved, but also the food safety of the composition in use is ensured.
[0017] The second technical object of the present invention is achieved through the following technical scheme: A preparation method of a composition with the function of moistening the lungs and relieving cough. The preparation process is to weigh the corresponding raw materials, decoct the raw materials, and finally perform post-treatment. The post-treatment process is to process the medicinal liquid obtained after decoction into a medicament.
[0018] Preferably, the specific process is to decoct water and the raw materials other than concentrated pear juice in a mass ratio of (1-3):1 for 2-3 times, each time for 1-3 hours, filter after each decoction, combine the filtrates and concentrate them to a relative density of 1.0-1.2 of the filtrate, and control the concentration temperature at 65-80°C.
[0019] Preferably, during the decocting process, platycodon root, polygonatum rhizome, and anemarrhena rhizome are first decocted and then added to the decocting pot to decoct together with lily, polygonatum odoratum, momordica grosvenori, eriobotrya japonica leaf, almond, sterculia lychnophora, honeysuckle flower, chrysanthemum flower, tangerine peel, Chinese date, gnaphalium affine, and rock candy in the decocting pot. Platycodon root is decocted first for 10-15 minutes, and polygonatum rhizome and anemarrhena rhizome are decocted first for 30 minutes, and the decocting temperature is 80-90°C.
[0020] Adopting the present invention, the advantage is that platycodon root, polygonatum rhizome, and anemarrhena rhizome are first decocted in a separate pot and then decocted together with other important raw materials, which can more completely stimulate the active ingredient extracts therein and bring better effects to the finally prepared composition.
[0021] Preferably, the addition method of morinda officinalis in the main raw materials is to combine the morinda officinalis oligosaccharide extracted from morinda officinalis with the paste at the end. The preparation method of the morinda officinalis oligosaccharide is as follows: (1) Put 5 parts of morinda officinalis into a round-bottom flask, then add 95 parts of 60% ethanol solution at 85°C, reflux with microwave assistance for 10 minutes, then cool the mixture to room temperature, and after high-speed centrifugation, extract the supernatant to obtain the morinda officinalis oligosaccharide extract; (2) The obtained preliminary morinda officinalis oligosaccharide extract still needs to be further purified to remove impurities. The obtained morinda officinalis extract is passed through a microporous adsorption resin to remove impurities: The extract is prepared into a sample solution with a concentration of 35-42 g / L, the resin column diameter-height ratio is 1:6, the sample volume / resin ratio is 1:25, elute with 12 BV of water, the flow rate is 2 BV / h, collect the eluate, and purify and concentrate the obtained eluate through an ultrafiltration membrane to obtain the morinda officinalis oligosaccharide extract.
[0022] Adopting the present invention, the advantage is that the extract of morinda officinalis oligosaccharide (MOO) usually contains a mixture of polysaccharides, proteins, small inorganic molecules, and other impurities, and these impurities must be removed to ensure that the quality and purity of MOO are not affected; in the present invention, after initially obtaining the morinda officinalis extract, the extract is further purified by resin, which not only has high separation efficiency but also can obtain a purer morinda officinalis extract.
[0023] Preferably, the preparation process of the Belamcanda chinensis and Scutellaria baicalensis Georgi extract is as follows: grind Belamcanda chinensis and Scutellaria baicalensis Georgi into powder, add water for decoction extraction 3 times according to the mass ratio of 15-25 to them, and decoct for 90 minutes each time; after the decocted extract is loaded onto an adsorption resin and washed with water and then with alcohol, collect the alcohol eluate. The dosage of water elution is 2 times the v / w resin amount, and the dosage of alcohol elution is 6 times the v / w resin amount; filter, concentrate the filtrate under reduced pressure to obtain an extract, and dry the extract under reduced pressure. The temperature for drying under reduced pressure is 60 °C to obtain the Belamcanda chinensis and Scutellaria baicalensis Georgi flavonoid extract.
[0024] Adopting the present invention, the advantages are as follows: when Belamcanda chinensis and Scutellaria baicalensis Georgi are combined, the yield of the obtained flavonoid extract is significantly higher than that obtained when the same amount of Belamcanda chinensis or Scutellaria baicalensis Georgi is extracted alone. When Belamcanda chinensis and Scutellaria baicalensis Georgi are combined in a ratio of 1:1, due to the solubilizing and enhancing solubility effect of Scutellaria baicalensis Georgi on Belamcanda chinensis, the transfer rates of tectoridin and baicalin in the extract are the highest, and the yield of the extract is the largest. This preparation method has strong practical application value and is easy to promote and use.
[0025] Preferably, the decoction is carried out 3 times. For the first decoction, filter after decocting for 1.5-2 hours, then add water with a weight of 1-3 times that of the raw materials to the filter residue and decoct for 1-1.5 hours for filtration, and then add water with a weight of 0.5-1 times that of the raw materials to the filter residue and decoct for 1-1.5 hours. Combine the 3 filtrates with the Belamcanda chinensis and Scutellaria baicalensis Georgi flavonoid extract to obtain a traditional Chinese medicine composition paste with the function of moistening the lungs and relieving cough.
[0026] Adopting the present invention, the advantages are as follows: through specially customized three-time decoction, and each decoction is for a specific time, and then adding water with a limited mass fraction ratio for multiple decoctions after decoction, a purer extract paste can be obtained.
[0027] Preferably, the obtained raw material extract is prepared into tablets or oral liquid preparations together with the auxiliary materials; use isomaltooligosaccharide, oligofructose, glycerol, inulin, pectin, xanthan gum, locust bean gum, and citric acid as auxiliary materials to prepare tablets, pills or oral liquid preparations.
[0028] Preferably, isomaltooligosaccharide is used to prepare the obtained raw material extract into an oral liquid preparation together with the auxiliary materials, and the mass fraction of isomaltooligosaccharide is 30-45 parts.
[0029] Adopting the present invention, the advantages are as follows: preparing the composition paste into an oral liquid preparation together with pharmaceutically acceptable auxiliary materials is the best choice based on the components in the composition; preparing it into an oral liquid preparation can not only retain the medicinal components of the composition raw materials to the greatest extent, but also bring better palatability to meet the needs of patients for the taste of drugs.
[0030] In summary, the present invention has the following beneficial effects: 1. The solution of the present invention selects concentrated pear juice, Siraitia grosvenorii, Polygonatum sibiricum, Folium Eriobotryae Japonicae, and rock sugar as the raw materials of a composition with the function of moistening the lungs and relieving cough, which can achieve excellent effects of moistening the lungs and relieving cough. Moreover, by combining Siraitia grosvenorii with almond, Sterculia lychnophora, Lonicera japonica, Platycodon grandiflorum, Chrysanthemum morifolium, Citrus reticulata Blanco, Chinese date, and Anemarrhena asphodeloides, the combination of heat and cold, the neutralization of medicinal properties, and the clearing of heat and relieving sore throat can be achieved. While maximizing the relief and improvement of lung-heat cough, it can also avoid the defects and sequelae caused by excessive cold or heat due to medicinal property conflicts; 2. The solution of the present invention also adds Belamcanda chinensis and Scutellaria baicalensis Georgi extracts to the main active ingredients, mainly for the flavonoid extracts therein. With the flavonoid extracts cooperating with other raw materials in the solution of the present invention, it has better effects of relieving cough and reducing phlegm, anti-inflammatory and analgesic. And with the preparation method in the solution, flavonoids can be extracted at a lower cost, reducing the production cost to a certain extent; 3. Adding bovine lung peptide to the raw materials, its combination with Lilium brownii var. viridulum, Polygonatum odoratum, and Siraitia grosvenorii greatly improves the efficacy of the composition in moistening the lungs and relieving cough. Bovine lung peptide contains various proteins, amino acids, and minerals, and can help improve lung function through the regulatory effect on bronchial mucosa, thereby normalizing its metabolism and enhancing its function; at the same time, it has a harmonizing and reducing effect on the toxicity and cold nature of the extract of Lilium brownii var. viridulum; the extract of Polygonatum odoratum contains rich dietary fiber. The compatibility of the dietary fiber in the extract of Polygonatum odoratum with bovine lung peptide, Lilium brownii var. viridulum, and Siraitia grosvenorii not only improves the efficacy of the composition in moistening the lungs and relieving cough, but also reduces the toxicity and cold nature of Lilium brownii var. viridulum; 4. Preferably preparing the composition described in the solution of the present invention into an oral liquid with pharmaceutically acceptable excipients is the best choice based on the components in the composition. It can not only retain the medicinal components of the composition raw materials to the greatest extent, but also bring better palatability to meet the patient's demand for the taste of the medicine; 5. A composition of the solution of the present invention not only has excellent functions of moistening the lungs and relieving cough, but also ensures the safety of medicine and food. Detailed implementation mode
[0031] The following specific examples are only explanations of the present invention, and they do not limit the present invention. Those skilled in the art can make modifications without creative contributions to the present examples according to needs after reading this specification, but as long as they are within the scope of the claims of the present invention, they are protected by the patent law.
[0032] It should be noted that the sum of the mass parts of all components in the following examples and comparative examples is not calculated based on 100 parts.
[0033] Example 1
[0034] The composition paste is made from the following raw materials in parts by weight: 65 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 3 parts of almond, 3 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 4 parts of eriobotrya japonica leaf, 3 parts of honeysuckle flower, 3 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide.
[0035] The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, weigh them according to the above parts by weight, add water with a weight twice that of the raw materials, and decoct for 3 times. Decoct for 2 hours for the first time, filter to obtain filtrate Q1, then add water with a weight equal to that of the raw materials and decoct for 1.5 hours, filter to obtain filtrate Q2, then add water with a weight 0.5 times that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q3. Combine the filtrates and conduct double-effect concentration under reduced pressure. Concentrate and filter to obtain a clear paste with a relative density of 1.16 at 70 °C.
[0036] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear paste and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70 °C.
[0037] Example 2
[0038] The composition paste is made from the following raw materials in parts by weight: 75 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 4 parts of almond, 3 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 6 parts of eriobotrya japonica leaf, 3 parts of honeysuckle flower, 4 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide.
[0039] The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, weigh them according to the above parts by weight, add water with a weight twice that of the raw materials, and decoct for 3 times. Decoct for 2 hours for the first time, filter to obtain filtrate Q1, then add water with a weight equal to that of the raw materials and decoct for 1.5 hours, filter to obtain filtrate Q2, then add water with a weight 0.5 times that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q3. Combine the filtrates and conduct double-effect concentration under reduced pressure. Concentrate and filter to obtain a clear paste with a relative density of 1.16 at 70 °C.
[0040] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear paste and boil for 1.1 hours to obtain a paste with a relative density of 1.37 at 70 °C.
[0041] Example 3
[0042] The composition paste is made from the following raw materials in parts by weight: 85 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 5 parts of almond, 5 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 7 parts of eriobotrya japonica leaf, 3 parts of honeysuckle flower, 5 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide.
[0043] The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, weigh them according to the above parts by weight, add water with a weight twice that of the raw materials, and decoct for 3 times. Decoct for 2 hours for the first time, filter to obtain filtrate Q1, then add water with a weight equal to that of the raw materials and decoct for 1.5 hours, filter to obtain filtrate Q2, then add water with a weight 0.5 times that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q3, combine the filtrates and perform double-effect decompression concentration, and concentrate and filter to obtain a clear paste with a relative density of 1.16 at 70°C.
[0044] (2) Add 85 parts of concentrated pear juice and 35 parts of isomaltooligosaccharide to the clear paste and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70°C.
[0045] Example 4
[0046] The composition paste is made from the following raw materials in parts by weight: 60 parts of concentrated pear juice, 3 parts of lily, 3 parts of polygonatum odoratum, 3 parts of almond, 2 parts of momordica grosvenori, 2 parts of sterculia lychnophora, 2 parts of polygonatum sibiricum, 2 parts of eriobotrya japonica leaf, 2 parts of honeysuckle flower, 2 parts of platycodon grandiflorum, 2 parts of chrysanthemum, 2 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide; The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, weigh them according to the above parts by weight, add water with a weight equal to that of the raw materials, and decoct for 2 times. Decoct for [missing time] hours for the first time, filter to obtain filtrate Q1, then add water with a weight equal to that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q2, combine the filtrates and perform double-effect decompression concentration, and concentrate and filter to obtain a clear paste with a relative density of 1.0 at 70°C.
[0047] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear paste and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70°C.
[0048] Example 5
[0049] The composition paste is made from the following raw materials in parts by weight: 90 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 8 parts of almond, 6 parts of momordica grosvenori, 6 parts of sterculia lychnophora, 6 parts of polygonatum sibiricum, 8 parts of eriobotrya japonica leaf, 4 parts of honeysuckle flower, 4 parts of platycodon grandiflorum, 4 parts of chrysanthemum, 4 parts of dried tangerine peel, 4 parts of Chinese date, 4 parts of rock sugar, and 35 parts of isomaltooligosaccharide; In addition to the above raw materials, it also includes 0.5 part of belamcanda chinensis and scutellaria baicalensis extract, 1 part of anemarrhena asphodeloides, 1 part of gnaphalium affine, and 0.5 part of bovine lung peptide.
[0050] The preparation process of the belamcanda chinensis and scutellaria baicalensis extract is as follows: Grind belamcanda chinensis and scutellaria baicalensis with a mass ratio of 1:1 into powder, add water for decoction extraction 3 times with a mass ratio of 15 to it, each time for 90 minutes; after the decocted extract is loaded onto an adsorption resin and washed with water and alcohol, collect the alcohol eluate, the dosage of water elution is 2 times the v / w resin amount, and the dosage of alcohol elution is 6 times the v / w resin amount; filter, and concentrate the filtrate under reduced pressure to obtain an extract, and dry the extract under reduced pressure, and the temperature of reduced pressure drying is 60 °C, then the belamcanda chinensis and scutellaria baicalensis flavonoid extract is obtained.
[0051] The preparation process of the bovine lung peptide is as follows: (1) Put 5 parts of morinda officinalis into a round-bottom flask, then add 95 parts of 60% ethanol solution at 85 °C, reflux with microwave assistance for 10 minutes, then cool the mixture to room temperature, after high-speed centrifugation, extract the supernatant, and thus obtain the morinda officinalis oligosaccharide extract; (2) The obtained preliminary morinda officinalis oligosaccharide extract still needs to be further purified to remove impurities. The obtained morinda officinalis extract is passed through a microporous adsorption resin to remove impurities: prepare the extract into a sample solution with a concentration of 35 g / L, the resin column diameter-height ratio is 1:6, the sample volume / resin ratio is 1:25, elute with 12 BV of water, the flow rate is 2 BV / h, collect the eluate, and purify and concentrate the obtained eluate through an ultrafiltration membrane, then the morinda officinalis oligosaccharide extract is obtained.
[0052] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, and weigh them according to the above parts by weight, add 3 times the weight of the raw materials of water, and decoct for 3 times. Decoct for 3 hours for the first time, filter to obtain filtrate Q1, then add 1 time the weight of the raw materials of water and decoct for 3 hours, filter to obtain filtrate Q2, then add 0.5 times the weight of the raw materials of water and decoct for 3 hours, filter to obtain filtrate Q3, combine the filtrates and perform double-effect concentration under reduced pressure, and concentrate and filter to obtain a clear paste with a relative density of 1.20 at 70 °C.
[0053] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear paste and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70 °C.
[0054] Example 6
[0055] The medicinal extract composition is made from the following raw materials by weight: 85 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 5 parts of almond, 5 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 7 parts of eriobotrya japonica leaf, 3 parts of honeysuckle flower, 5 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide; In addition to the above raw materials, it further includes 2 parts of belamcanda chinensis and scutellaria baicalensis extract, 3 parts of anemarrhena asphodeloides, 3 parts of gnaphalium affine, and 1 part of bovine lung peptide.
[0056] The preparation process of the belamcanda chinensis and scutellaria baicalensis extract is as follows: Grind belamcanda chinensis and scutellaria baicalensis with a mass ratio of 1:1 into powder, add water for decoction extraction 3 times with a mass ratio of 25 to it, each time for 90 minutes; after the decocted extract is loaded onto an adsorption resin and washed with water and then with alcohol, collect the alcohol eluate, the amount of water elution is 2 times v / w resin amount, and the amount of alcohol elution is 6 times v / w resin amount; filter, and concentrate the filtrate under reduced pressure to obtain an extract paste, and dry the extract paste under reduced pressure, and the reduced pressure drying temperature is 60°C, thus obtaining the belamcanda chinensis and scutellaria baicalensis flavonoid extract.
[0057] The preparation process of the bovine lung peptide is as follows: (1) Put 5 parts of morinda officinalis into a round-bottom flask, then add 95 parts of 60% ethanol solution at 85°C, carry out microwave-assisted reflux for 10 minutes, then cool the mixture to room temperature, after high-speed centrifugation, extract the supernatant, thus obtaining the morinda officinalis oligosaccharide extract; (2) The obtained preliminary morinda officinalis oligosaccharide extract still needs to be further purified to remove impurities. Remove impurities from the obtained morinda officinalis extract through a microporous adsorption resin: prepare the extract into a sample solution with a concentration of 42 g / L, the resin column diameter-height ratio is 1:6, the sample volume / resin ratio is 1:25, elute with 12 BV of water, the flow rate is 2 BV / h, collect the eluate, and purify and concentrate the obtained eluate through an ultrafiltration membrane, thus obtaining the morinda officinalis oligosaccharide extract.
[0058] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica leaf, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date, and weigh them according to the above weight parts, add water with a weight 2 times that of the raw materials, and carry out decoction 3 times. Decoct for 2 hours for the first time, filter to obtain filtrate Q1, then add water with a weight 1 time that of the raw materials and decoct for 1.5 hours, filter to obtain filtrate Q2, then add water with a weight 0.5 times that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q3, combine the filtrates and carry out double-effect concentration under reduced pressure, and concentrate and filter to obtain a clear paste with a relative density of 1.16 at 70°C.
[0059] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear extract and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70 °C.
[0060] Example 7
[0061] The composition paste is made from the following raw materials in parts by weight: 85 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 5 parts of almond, 5 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 7 parts of eriobotrya japonica leaf, 3 parts of honeysuckle, 5 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of Chinese date, 2 parts of rock sugar, 35 parts of isomaltooligosaccharide; In addition to the above raw materials, it also includes 1.5 parts of the extract of belamcanda chinensis and scutellaria baicalensis, 2 parts of anemarrhena asphodeloides, 2 parts of gnaphalium affine, and 0.8 part of bovine lung peptide.
[0062] The preparation process of the extract of belamcanda chinensis and scutellaria baicalensis is as follows: Grind belamcanda chinensis and scutellaria baicalensis with a mass ratio of 1:1 into powder, add water for decoction extraction 3 times with a mass ratio of 20 to it, each time for 90 min; after the decocted extract is loaded onto an adsorption resin and washed with water and then with alcohol, collect the alcohol eluate, the amount of water elution is 2 times v / w resin amount, and the amount of alcohol elution is 6 times v / w resin amount; filter, concentrate the filtrate under reduced pressure to obtain an extract, and dry the extract under reduced pressure, the temperature of reduced pressure drying is 60 °C, and the extract of flavonoids of belamcanda chinensis and scutellaria baicalensis is obtained.
[0063] The preparation process of the bovine lung peptide is as follows: (1) Put 5 parts of morinda officinalis in a round-bottom flask, then add 95 parts of 60% ethanol solution at 85 °C, reflux with microwave assistance for 10 minutes, then cool the mixture to room temperature, after high-speed centrifugation, extract the supernatant, and thus obtain the morinda officinalis oligosaccharide extract; (2) The obtained preliminary morinda officinalis oligosaccharide extract still needs to be further purified to remove impurities. Remove impurities from the obtained morinda officinalis extract through a microporous adsorption resin: Prepare the extract into a sample solution with a concentration of 40 g / L, the ratio of the diameter to the height of the resin column is 1:6, the ratio of the sample volume to the resin is 1:25, elute with 12 BV of water, the flow rate is 2 BV / h, collect the eluate, and purify and concentrate the obtained eluate through an ultrafiltration membrane to obtain the morinda officinalis oligosaccharide extract.
[0064] The preparation method of the traditional Chinese medicine composition includes the following steps: (1) Screen lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica, honeysuckle, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and jujube, weigh them according to the above weight parts, add water with a weight 2 times that of the raw materials, and decoct 3 times. Decoct for 2 hours for the first time, filter to obtain filtrate Q1, then add water with a weight 1 time that of the raw materials and decoct for 1.5 hours, filter to obtain filtrate Q2, then add water with a weight 0.5 times that of the raw materials and decoct for 1 hour, filter to obtain filtrate Q3, combine the filtrates and perform double-effect concentration under reduced pressure, and concentrate and filter to obtain a clear extract with a relative density of 1.16 at 70°C.
[0065] (2) Add concentrated pear juice and isomaltooligosaccharide to the clear extract and boil for 1.2 hours to obtain a paste with a relative density of 1.37 at 70°C.
[0066] Example 8
[0067] The composition paste is made from the following raw materials in weight parts: 85 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum odoratum, 5 parts of almond, 5 parts of momordica grosvenori, 3 parts of sterculia lychnophora, 3 parts of polygonatum sibiricum, 7 parts of eriobotrya japonica, 3 parts of honeysuckle, 5 parts of platycodon grandiflorum, 3 parts of chrysanthemum, 3 parts of dried tangerine peel, 2 parts of jujube, 2 parts of rock sugar, and 35 parts of isomaltooligosaccharide; In addition to the above raw materials, it also includes 2 parts of the extract of belamcanda chinensis and scutellaria baicalensis, 1 part of anemarrhena asphodeloides, 1.5 parts of gnaphalium affine, and 0.6 part of bovine lung peptide.
[0068] The preparation process of the extract of belamcanda chinensis and scutellaria baicalensis is as follows: The preparation process of the extract of belamcanda chinensis and scutellaria baicalensis is to grind belamcanda chinensis and scutellaria baicalensis with a mass ratio of 1:1 into powder, add water with a mass ratio of 19 to it and decoct and extract 3 times, 90 minutes each time; after the decocted extract is loaded onto an adsorption resin and washed with water and then with alcohol, collect the alcohol eluate, the dosage of water elution is 2 times v / w resin amount, and the dosage of alcohol elution is 6 times v / w resin amount; filter, concentrate the filtrate under reduced pressure to obtain an extract, and dry the extract under reduced pressure, the reduced pressure drying temperature is 60°C, and the extract of flavonoids from belamcanda chinensis and scutellaria baicalensis is obtained.
[0069] The preparation process of bovine lung peptide is as follows: (1) Put 5 parts of morinda officinalis into a round-bottom flask, then add 95 parts of 60% ethanol solution at 85°C, reflux with microwave assistance for 10 minutes, then cool the mixture to room temperature, after high-speed centrifugation, extract the supernatant, and the oligosaccharide extract of morinda officinalis is obtained; (2) The obtained preliminary oligosaccharide extract of morinda officinalis needs to be further purified to remove impurities. The obtained extract of morinda officinalis is passed through a microporous adsorption resin to remove impurities: prepare the extract into a sample solution with a concentration of 38 g / L, the diameter-height ratio of the resin column is 1:6, the sample volume / resin ratio is 1:25, elute with 12 BV of water, the flow rate is 2 BV / h, collect the eluate, and purify and concentrate the obtained eluate through an ultrafiltration membrane, and the oligosaccharide extract of morinda officinalis is obtained.
[0070] The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) Lily, polygonatum odoratum, almond, momordica grosvenori, sterculia lychnophora, polygonatum sibiricum, eriobotrya japonica, honeysuckle flower, platycodon grandiflorum, chrysanthemum, dried tangerine peel, and Chinese date are screened and weighed according to the above weight parts, and water 2 times the weight of the raw materials is added, and decocted 3 times. The first decoction is for 2 hours, and the filtrate Q1 is obtained by filtration. Then, water 1 time the weight of the raw materials is added and decocted for 1.5 hours, and the filtrate Q2 is obtained by filtration. Then, water 0.5 times the weight of the raw materials is added and decocted for 1 hour, and the filtrate Q3 is obtained by filtration. The filtrates are combined and concentrated by double-effect under reduced pressure, and the clear paste with a relative density of 1.16 at 70 °C is obtained by concentration and filtration.
[0071] (2) Concentrated pear juice and isomaltooligosaccharide are added to the clear paste and boiled for 1.2 hours to obtain a paste with a relative density of 1.37 at 70 °C.
[0072] Comparative Example 1
[0073] This comparative example is a commonly seen cough product (cough syrup, cough medicine) on the market.
[0074] In the above examples and comparative examples, 80 subjects with cough symptoms in each group who volunteered to receive conditioning were selected. The subjects were divided into 8 groups and orally administered the paste prepared in Examples 1-8 and the cough medicine or cough syrup in Comparative Example 1, 14 grams each time, 3 times a day, and could be eaten directly. After continuous consumption for 9 days, the collected feedback results of Examples 1-8 are shown in Table 1 below: Table 1 Conditioning curative effects on cough subjects (number of cases, %).
[0075]
[0076]
[0077] From the results of the collection table of the conditioning curative effects on cough subjects above, it can be concluded that compared with the comparative example, the composition paste with the function of moistening the lungs and relieving cough prepared by the scheme of the present invention has a very good effect on improving and relieving the symptoms of clearing heat and moistening the lungs and relieving cough; in addition, the paste prepared under the preparation conditions and raw material mass parts of Example 7 has the best effect, and the effective rate can reach 65% on the first day, and the effective rate on the ninth day can reach 98%, and the cure rate can reach 72%; compared with Examples 1-3, it can be seen that combining the paste with two extracts and adding anemarrhena asphodeloides and gnaphaliurn affine in the raw materials can have a better improvement effect on improving lung heat cough.
Claims
1. A composition having the function of moistening the lungs and relieving cough, characterized in that: The Chinese medicine composition comprises main raw materials of active ingredients and post-processing auxiliary materials; the main raw materials comprise 60-90 parts of concentrated pear juice, 3-8 parts of lily bulbs, 3-8 parts of polygonatum odoratum, 2-6 parts of momordica grosvenori, 2-6 parts of polygonatum sibiricum, 2-6 parts of loquat leaves and 2-4 parts of crystal sugar; the auxiliary materials comprise isomaltooligosaccharide, oligofructose, glycerin, inulin, pectin, xanthan gum, locust bean gum and citric acid; the dosage form of the Chinese medicine composition is tablets, granules, pills, syrup and oral liquid.
2. A composition having the function of moistening the lungs and relieving cough according to claim 1, characterized in that: The main raw materials of the active ingredients also include 3-8 parts of almonds, 2-6 parts of Sterculia lychnophora, 2-4 parts of honeysuckle, 2-4 parts of platycodon, 2-4 parts of chrysanthemum, 2-4 parts of tangerine peel and 2-4 parts of jujube.
3. A composition having the function of moistening the lungs and relieving cough according to claim 2, characterized in that: The active ingredients in the main raw material also include 0.5-2 parts of Sichuan Iris Root and Scutellaria baicalensis extract, 1-3 parts of Anemarrhena Rhizoma, 1-3 parts of Artemisia selengensis, 0.1-1.2 parts of Morinda officinalis and 0.5-1 parts of bovine lung peptide.
4. The composition having the function of moistening the lungs and relieving cough according to claim 1, characterized in that: The main raw materials include 80-90 parts of concentrated pear juice, 8 parts of lily, 8 parts of polygonatum, 5 parts of momordica grosvenori, 3 parts of polygonatum, 7 parts of loquat leaves, 2 parts of crystal sugar, 5 parts of almonds, 3 parts of sterculia lychnophora, 3 parts of honeysuckle, 5 parts of platycodon, 3 parts of chrysanthemum, 3 parts of tangerine peel, 2 parts of jujube, 0.5-2 parts of Sichuan belamcanda chinensis and scutellaria baicalensis extract, 1-3 parts of anemarrhena asphodeloides, 1-3 parts of artemisia selengensis and 0.5-1 parts of bovine lung peptide, and the weight parts are not calculated as 100 parts.
5. A method for preparing a composition having the function of moistening the lungs and relieving cough, characterized in that: The composition with lung moistening and cough relieving function according to any one of claims 1 to 3 is used as a raw material for preparation, and the preparation process comprises weighing the corresponding raw materials, decocting the raw materials, and finally performing post-processing, wherein the post-processing process comprises processing the decoction obtained into a medicament; The specific process is to add water and raw materials except concentrated pear juice in a mass ratio of (1-3):1 and boil them for 2-3 times, each time for 1-3 hours, and filter after each boiling, combine the filtrate and concentrate it until the relative density of the filtrate is 1.0-1.2, and the concentration temperature is controlled at 65-80°C.
6. The method for preparing a composition having the function of moistening the lungs and relieving cough according to claim 4, characterized in that: During the decoction process, Platycodon grandiflorum, Polygonatum sibiricum and Anemarrhena asphodeloides are first decocted and then put into the decoction pot and decocted together with lily, polygonatum odoratum, momordica grosvenori, loquat leaf, almond, Sterculia lychnophora, honeysuckle, chrysanthemum, tangerine peel, jujube, Gnaphalium sibiricum and crystal sugar in the decoction pot. Platycodon grandiflorum is first decocted for 10-15 minutes, Polygonatum sibiricum and Anemarrhena asphodeloides are first decocted for 30 minutes, and the decoction temperature is 80-90°C.
7. The method for preparing a composition having the function of moistening the lungs and relieving cough according to claim 4, characterized in that: The method of adding Morinda officinalis to the main raw material is to combine the Morinda officinalis extract and Morinda officinalis oligosaccharide with the paste at the end. The preparation method of the Morinda officinalis oligosaccharide is as follows: (1) 5 parts of Morinda officinalis are placed in a round-bottom flask, and then 95 parts of 60% ethanol solution are added at 85°C, and microwave-assisted reflux is performed for 10 minutes. The mixture is then cooled to room temperature, and after high-speed centrifugation, the supernatant is extracted to obtain the Morinda officinalis oligosaccharide extract; (2) The obtained preliminary Morinda officinalis oligosaccharide extract needs to be further purified to remove impurities. The obtained Morinda officinalis extract is passed through a microporous adsorption resin to remove impurities: the extract is prepared into a sample solution with a concentration of 35-42g / L, the resin column diameter-to-height ratio is 1:6, the sample volume / resin ratio is 1:25, and it is eluted with 12BV of water at a flow rate of 2BV / h. The eluate is collected, and the obtained eluate is purified and concentrated through an ultrafiltration membrane to obtain the Morinda officinalis oligosaccharide extract.
8. The method for preparing a composition having the function of moistening the lungs and relieving cough according to claim 4, characterized in that: The preparation process of the Sichuan Shegan Huangcen extract is as follows: Sichuan Shegan and Huangcen with a mass ratio of 1:1 are ground into powder, and water with a mass ratio of 15-25 is added to the powder and the powder is decocted and extracted for 3 times, each time for 90 minutes; the decocted extract is washed with water and alcohol on an adsorption resin, and the alcohol eluate is collected, wherein the amount of water elution is 2 times the v / w amount of the resin, and the amount of alcohol elution is 6 times the v / w amount of the resin; filtering, decompressing and concentrating the filtrate to obtain an extract, and decompressing and drying the extract at a decompressed drying temperature of 60°C to obtain the Sichuan Shegan Huangcen flavonoid extract.
9. The method for preparing a composition having the function of moistening the lungs and relieving cough according to claim 4, characterized in that: The decoction is performed three times, the first decoction is performed for 1.5-2 hours and filtered, then 1-3 times the weight of water of the raw material is added to the filter residue and the mixture is decocted for 1-1.5 hours and filtered, then 0.5-1 times the weight of water of the raw material is added to the filter residue and the mixture is decocted for 1-1.5 hours, and the filtrates from the three times are combined with the Chuanxionggan and Scutellaria baicalensis flavonoids extract to obtain a traditional Chinese medicine composition paste having the function of moistening the lungs and relieving cough; The obtained raw material extract and the auxiliary materials are prepared into tablets or oral liquids; and tablets, pills or oral liquids are prepared using isomaltooligosaccharide, oligofructose, glycerol, inulin, pectin, xanthan gum, locust bean gum and citric acid as auxiliary materials.
10. The method for preparing a composition having the function of moistening the lungs and relieving cough according to claim 9, characterized in that: The obtained raw material extract and auxiliary materials are prepared into oral liquid by using oligomaltose, and the mass fraction of oligomaltose is 30-45 parts.