Healthcare oil capable of stimulating menstrual flow and relaxing collaterals and preparation method thereof

Abstract

The invention relates to meridian-stimulating and collateral-relaxing health-care oil and a preparation method thereof, and belongs to the field of external traditional Chinese medicine essential oil preparations. The health-care oil is prepared by scientifically compounding natural plant essential oil such as ligusticum wallichii oil, bitter apricot kernel oil and semiliquidambar formosana oil with base oil such as tea seed oil and coconut oil, has the health-care effects of promoting blood circulation to remove blood stasis and relaxing tendons and dredging collaterals, and is suitable for improving sub-health symptoms such as meridian blockage, nodules and local pain. According to the invention, a specific essential oil combination (such as the synergistic interaction of ligusticum wallichii oil and wintergreen oil) is innovatively screened, and a gradient permeation formula technology is combined, so that the transdermal absorption rate of active components is increased to 32% or above. Clinical verification shows that the effective rate of relieving the shoulder and neck clogging symptom reaches 96.5%, and skin irritation is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of compound traditional Chinese medicine essential oils, and specifically relates to an external health care oil for regulating microcirculation through multiple channels and a preparation process thereof. Background Art

[0002] Existing essential oil products for dredging collaterals mostly use a single base oil for dilution, and there are problems such as poor permeability (the transdermal rate is generally <15%) and easy volatilization and inactivation of components. In traditional formulas, too high a content of camphor is likely to cause skin allergies (the allergy rate of commercially available products >18%). The present invention solves the technical difficulties through the following innovations: 1. Molecular gradient design: The base oil is compounded with medium-chain (coconut oil) and long-chain fatty acids (tea seed oil) to form a gradient penetration system; 2. Synergistic effect: Chuanxiong essential oil (containing ligustilide) and wintergreen essential oil (containing methyl salicylate) are proportioned at 5:3, and the anti-inflammatory activity is increased by 2.1 times (detected by MTT method); 3. Stability optimization: Ganoderma spore oil (containing ganoderic triterpenes) is added as a natural antioxidant, and the accelerated test shows that the component retention rate >97%. Summary of the Invention

[0003] 1. Scientific formula ratio: Blood-activating group: Chuanxiong essential oil (dilating capillaries), safflower essential oil (inhibiting platelet aggregation) Permeation-promoting group: Litsea cubeba essential oil (containing citral, enhancing the fluidity of the stratum corneum), clove essential oil (containing eugenol, opening skin channels) Balancing group: Bergamot essential oil (regulating odor), tangerine peel essential oil (reducing the irritation of camphor) 2. Innovative points of the process: Segmented extraction: Supercritical CO 2 The extraction retains thermosensitive components (such as the yield of angelica volatile oil is increased by 25%) Directional homogenization: Ultrasonic treatment makes the particle size of the essential oil ≤100 nm, and the transdermal time is shortened to 15 minutes (determined by fluorescence tracer method) Detailed Description of the Invention Embodiment

[0004] 1. Raw material ratio: Active essential oil group (35%): Chuanxiong essential oil 8%, bitter almond oil 5%, half wind lotus oil 4%, ginseng oil 3%, ganoderma spore oil 4%, litsea cubeba essential oil 6%, wintergreen essential oil 10%, camphor 1%, angelica essential oil 5%, eucalyptus essential oil 3%, clove essential oil 2%, lemongrass oil 2%, tangerine peel essential oil 3%, bergamot essential oil 2% Base oil (65%): Tea seed oil (40%), coconut oil (30%), sunflower seed oil (30%) 2. Preparation steps: (1) Essential oil extraction: Ligusticum wallichii and Angelica sinensis are extracted by supercritical CO 2 (pressure 30 MPa, temperature 50 °C, CO 2 flow rate 25 L / h), and the yields are 1.8% and 1.2% respectively; The essential oil of Ilex purpurea leaves is obtained by steam distillation (ratio of material to liquid 1:15, distillation time 4 h), and the essential oil yield is 0.7%.

[0005] (2) Compound process: Mix the base oil and heat it to 42 °C, add camphor and Ganoderma lucidum spore oil and stir until completely dissolved; Add the active essential oils in order of decreasing molecular weight, and stir for 5 minutes after adding each one; Perform ultrasonic homogenization treatment for 25 minutes, and fill and store in the dark.

[0006] V. Supplementary experimental data 1. Quality inspection Ligustilide content: GC-MS method (HP-5MS chromatographic column, programmed temperature rise 100 °C → 280 °C), requirement ≥ 1.2 mg / mL Peroxide value: detected according to GB / T 5538, ≤ 5.0 mmol / kg after 6 months of accelerated test 2. Comparison of transdermal performance (Franz diffusion cell, ex vivo human skin) Group 24h cumulative permeation amount (μg / cm²) Steady-state flow rate (μg / cm²·h) This invention 325 ± 18 13.5 ± 0.9 A certain collaterals dredging essential oil 148 ± 12 6.2 ± 0.5 3. Clinical effect (90 patients with meridian stasis, randomized double-blind trial) Index Experimental group (n = 45) Control group (n = 45) Nodule shrinkage rate 68.9% 37.8% Pain relief time 25.3 ± 6.2 min 48.7 ± 10.5 min Skin tolerance 100% 82.2%. Description of the drawings Figure 1 is a process flow chart of segmented extraction [Schematic diagram of dual-channel extraction] Left channel (supercritical CO 2 extraction): Ligusticum wallichii / Angelica sinensis raw material → extraction kettle (30 MPa, 50 °C) → separation kettle → essential oil collection tank (yield 1.8% / 1.2%) Right channel (steam distillation): Holly leaves → Distillation flask (feed liquid ratio of 1:15) → Condenser → Oil-water separator (yield 0.7%) Confluence point: Molecular sieve purification device (marked "removing macromolecular impurities").

Claims

1. A health-care oil for promoting blood circulation and relaxing collaterals, characterized in that It is composed of the following raw materials in weight percentage: Active essential oil group 25-40%, base oil 60-75%; The active essential oil group includes the following ingredients: 5-10% chuanxiong oil, 3-8% bitter almond oil, 2-6% hemlock oil, 1-5% ginseng oil, 2-5% ganoderma lucidum spore oil, 4-8% litsea cubeba oil, 5-12% wintergreen oil, 0.5-2% camphor, 3-7% angelica oil, 2-5% eucalyptus oil, 1-4% clove oil, 1-3% lemongrass oil, 2-5% tangerine peel oil, and 1-3% bergamot oil; The base oil is prepared by mixing tea seed oil, coconut oil and sunflower seed oil in a weight ratio of (3-5): (2-4): (1-2).

2. The health care oil as claimed in claim 1, characterized in that The preparation method of the active essential oil group comprises: (1) Extract rhizomes of Chuanxiong and Angelica sinensis with supercritical CO2 at a pressure of 25-35 MPa and a temperature of 45-55°C to obtain Chuanxiong oil and Angelica sinensis oil; (2) Cold-pressing essential oils from peels of tangerine peel, bergamot, and other fruit peels; (3) Extract essential oils from leaf materials such as holly and eucalyptus by steam distillation, with the condensation temperature ≤30°C.

3. The preparation method according to claim 1, characterized in that The following steps are involved: (1) Heat the base oil to 40-45°C, add camphor and Ganoderma lucidum spore oil in turn and stir to dissolve; (2) Gradient mixing of active essential oils: first add large molecular oils such as Chuanxiong oil and Angelica oil, then add small molecular oils such as wintergreen oil and clove oil, and finally add lemongrass oil and bergamot oil; (3) Homogenization: Use an ultrasonic disperser (power 300 W, frequency 28 kHz) for 20-30 minutes and let it stand for 48 hours to mature.

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