Traditional Chinese medicine composition for treating plateau mild cold as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for treating plateau mild cold and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The invention provides a traditional Chinese medicine composition aiming at the problems that the existing western medicine for treating the plateau mild cold generally needs more than one week to relieve the symptom, the symptom progress and the disease course are difficult to effectively inhibit at the initial stage, part of patients even need 2-3 weeks to completely recover, and the production activity, travel, daily life and the like in plateau regions are seriously influenced. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of herba schizonepetae, 5 parts of radix saposhnikoviae, 5 parts of folium eriobotryae, 15 parts of rhizoma atractylodis macrocephalae, 10 parts of apricot kernels, 10 parts of radix platycodonis, 10 parts of flos magnoliae, 10 parts of radix isatidis, 15 parts of agastache rugosus, 10 parts of folium perillae, 5 parts of amomum cardamomum and 5 parts of radix astragali. The traditional Chinese medicine not only has a more remarkable curative effect and a shorter treatment cycle, but also can block the pathological process of mild cold developing from a mild symptom to a severe symptom in a plateau environment through the effects of strengthening the body resistance, eliminating pathogenic factors and regulating yin and yang, and prevent pathological changes such as internal transmission of pathogenic factors and intermingled phlegm and blood stasis.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and specifically discloses a traditional Chinese medicine composition for treating mild colds at high altitudes, a preparation method thereof, and an application thereof. Background Art

[0002] A cold, which is called "common cold" or "exogenous superficial syndrome" in traditional Chinese medicine, belongs to the syndrome of "wind pathogen attacking the superficies and the lung-defense failing to disperse". In plain areas, common colds are mostly caused by wind pathogens (wind-cold, wind-heat) attacking the lung-defense, with a relatively shallow disease location and a short course of disease, which conforms to the treatment principle of "for those on the skin, induce sweating to relieve the illness" (from "Plain Questions: Theory of Correspondence between Yin and Yang and Manifestation of Images"). Generally, it can heal itself in 5 - 7 days. However, the high-altitude environment is characterized by "high cold, low oxygen, strong wind, and heavy humidity", which is likely to lead to a special pathogenesis of "cold-dampness binding the superficies and deficiency of the lung and spleen qi". Although in the initial stage of a high-altitude cold, there are also manifestations of wind-cold attacking the superficies such as nasal congestion, clear nasal discharge, and slight aversion to wind-cold, due to "insufficient yang qi and internal accumulation of damp turbidity" at high altitudes, pathogenic factors are more likely to enter from the superficies into the interior, stagnating the spleen yang and congesting the lung qi. Therefore, the course of disease is prolonged, and complex syndromes of "wind-cold on the superficies not resolved while internal dampness has occurred" are commonly seen.

[0003] Syndrome characteristics of mild colds in the high-altitude environment: Initial stage (wind-cold-dampness superficies syndrome): Nasal congestion, sneezing, clear nasal discharge, slight aversion to wind-cold, thin white and slightly greasy tongue coating, floating and tight or string-like and tight pulse, indicating "wind-cold with dampness"; Middle stage (lung-spleen qi stagnation syndrome): Cough gradually worsens, sputum is white and sticky, accompanied by abdominal distension, poor appetite, loose stools, white greasy tongue coating, slippery and moderate pulse, reflecting "damp pathogen stagnating the spleen and the lung failing to disperse and descend"; Late stage (phlegm-dampness stagnating and transforming into heat syndrome): Sputum turns yellow and thick, dry mouth but not willing to drink, yellow greasy tongue coating, slippery and rapid pulse, indicating "dampness stagnating and transforming into heat", but the heat manifestation is not obvious, and it is still mainly characterized by damp turbidity.

[0004] Limitations of Western medicine treatment and advantages of traditional Chinese medicine: Although Western medicines (such as paracetamol, pseudoephedrine hydrochloride, and dextromethorphan hydrobromide capsules, dextromethorphan hydrobromide oral solution) can relieve symptoms, in the high-altitude environment of "insufficient vital qi and sticky damp pathogen", simple antiviral or symptomatic treatment often fails to achieve quick results. The course of disease of some patients can be prolonged for 2 - 3 weeks, and even transform into severe cases due to "lingering pathogen due to deficiency of vital qi". Summary of the Invention

[0005] In the existing technology, it is difficult to effectively prevent the progression of mild colds to severe colds in the plateau area with Western medicine treatment. Moreover, it takes at least one week for the symptoms to relieve, and it takes two to three weeks for a small number of patients to relieve the symptoms. How to effectively prevent the transformation of mild colds to severe colds in the plateau environment and accelerate the recovery speed is a key problem to be solved urgently. The present invention provides a traditional Chinese medicine composition for treating mild colds in the plateau area, its preparation method and application. Traditional Chinese medicine treatment emphasizes "treatment based on the concept of holism, treatment based on syndrome differentiation, and treatment according to the time, place and individual". In view of the characteristics of "cold-dampness mixture and simultaneous exterior and interior syndromes" of mild colds in the plateau environment, the three methods of "dispersing pathogenic cold from the exterior, strengthening the spleen and resolving dampness, and dispersing lung qi and resolving phlegm" should be used simultaneously. Only by expelling exogenous pathogenic factors and regulating internal dampness can "strengthening healthy qi and eliminating pathogenic factors, and cutting off the disease trend" be achieved, effectively shortening the course of disease and preventing the transformation from mild to severe. This idea fully embodies the essence of traditional Chinese medicine of "concept of holism" and "treatment based on syndrome differentiation", and has unique value for the prevention and treatment of mild colds in the plateau area.

[0006] The technical solution adopted by the present invention is as follows:

[0007] A traditional Chinese medicine composition for treating mild colds in the plateau area, which is composed of the following raw materials in parts by weight: 10 parts of Schizonepeta tenuifolia Briq., 5 parts of Saposhnikovia divaricata (Turcz.) Schischk., 5 parts of Eriobotrya japonica (Thunb.) Lindl., 15 parts of Atractylodes macrocephala Koidz., 10 parts of Armeniaca vulgaris Lam. var. ansu (Maxim.) Yü et Lu, 10 parts of Platycodon grandiflorus (Jacq.) A. DC., 10 parts of Magnolia liliflora Desr., 10 parts of Isatis tinctoria L., 15 parts of Pogostemon cablin (Blanco) Benth., 10 parts of Perilla frutescens (L.) Britt., 5 parts of Amomum kravanh Pierre ex Gagnep., 5 parts of Astragalus membranaceus (Fisch.) Bunge.

[0008] This compound formula follows the theory of "correspondence between man and nature", and in view of the pathogenesis characteristics of "wind-cold attacking the exterior, damp turbidity stagnating the spleen, and failure of the lung-defense qi to disperse" in the plateau area, the formula principle of "strengthening healthy qi and eliminating pathogenic factors, and treating the triple energizer simultaneously" is adopted. In the formula, Schizonepeta tenuifolia Briq. and Saposhnikovia divaricata (Turcz.) Schischk. are the monarch drugs, which are pungent-warm in nature and can relieve the exterior syndrome to open the pores; Pogostemon cablin (Blanco) Benth. and Perilla frutescens (L.) Britt. are the minister drugs, which can aromatically resolve dampness to awaken the spleen and regulate the triple energizer; Atractylodes macrocephala Koidz. and Astragalus membranaceus (Fisch.) Bunge are used as adjuvant drugs to strengthen the spleen and replenish qi to consolidate the yang qi of the defensive aspect, Armeniaca vulgaris Lam. var. ansu (Maxim.) Yü et Lu and Platycodon grandiflorus (Jacq.) A. DC. can disperse and descend lung qi to restore qi movement, Isatis tinctoria L. and Magnolia liliflora Desr. can clear heat and detoxify to benefit the nasal orifices, and Eriobotrya japonica (Thunb.) Lindl. is added to lower the adverse qi of the lung and relieve cough, and Amomum kravanh Pierre ex Gagnep. can resolve dampness and promote qi movement. All the drugs are used together to achieve the effects of dispersing wind-cold, dispersing lung qi and relieving the exterior syndrome, strengthening the spleen and resolving dampness, and clearing heat and detoxifying, which is in line with the special environment of "high altitude, cold, windy, low oxygen and heavy humidity" in the plateau area. Clinical studies have shown that this formula can not only expel the pathogenic factors of the six exogenous evils, but also regulate the qi, blood, yin and yang of the body, and has significant anti-inflammatory, antipyretic, phlegm-dissolving and cough-relieving, and immune-regulating effects. It has a definite curative effect on the lung-defense qi exterior syndrome such as aversion to cold and fever, nasal congestion and runny nose, cough and sore throat at the initial stage of exogenous diseases in the plateau environment, can effectively cut off the disease trend and prevent transmission, fully reflecting the preventive treatment of disease thought of traditional Chinese medicine of "preventing the progression of disease when it has occurred".

[0009] Each traditional Chinese medicine component and its combination have the following effects:

[0010] 1) Exterior-resolving and pathogenic factor-expelling group (for wind-cold-dampness pathogenic factors in the plateau area)

[0011] Schizonepeta tenuifolia Briq.: Pungent-warm in nature, relieving the exterior syndrome and dispersing wind pathogen → opening the pores to disperse exterior cold; inducing sweating to relieve the exterior syndrome, and dispersing stasis and stopping bleeding.

[0012] Ledebouriella seseloides: expelling wind and dampness, relieving spasm and pain → preventing wind pathogens on the plateau from invading the collaterals; expelling wind and relieving exterior syndrome, eliminating dampness and relieving pain, stopping spasm.

[0013] Perilla leaf: dispersing cold and regulating qi, regulating nutrient qi and widening the middle energizer → regulating nutrient qi and defensive qi, assisting the lung qi to disperse; dispersing cold, regulating qi and nutrient qi, promoting qi movement and widening the middle energizer, regulating the stomach and stopping vomiting.

[0014] Astragalus membranaceus: replenishing qi and consolidating the exterior, expelling pathogenic factors outward → enhancing the ability to resist exogenous pathogens on the exterior; replenishing qi and consolidating the exterior, tonifying qi and nourishing blood.

[0015] Schizonepeta tenuifolia + Ledebouriella seseloides → enhancing the power of expelling wind and cold, fitting the characteristics of preponderance of wind-cold on the plateau.

[0016] Ledebouriella seseloides + Astragalus membranaceus → "consolidating the exterior without retaining pathogenic factors, expelling pathogenic factors without damaging healthy qi", preventing repeated colds on the plateau.

[0017] 2) Lung-qi dispersing and phlegm-resolving group (for un-dispersed lung qi on the plateau)

[0018] Apricot kernel: lowering qi and relieving cough, moistening the intestines and promoting defecation → lowering the turbid qi in the lung, preventing constipation on the plateau; resolving phlegm and relieving cough, calming asthma, moistening the intestines, lowering qi and relieving obstruction.

[0019] Platycodon grandiflorum: dispersing lung qi and resolving phlegm, promoting the discharge of phlegm by relieving sore throat and discharging pus → lifting the lung qi, assisting the discharge of phlegm; dispersing lung qi, resolving phlegm, relieving sore throat, discharging pus.

[0020] Loquat leaf: clearing the lung and descending adverse qi, relieving cough and resolving phlegm → regulating the lung and stomach, preventing adverse qi and vomiting; clearing the lung and relieving cough, descending adverse qi and stopping vomiting.

[0021] Magnolia flower bud: dispersing wind-cold, dredging the nasal orifice → improving nasal congestion and runny nose on the plateau; dispersing wind-cold, dredging the nasal orifice.

[0022] Apricot kernel + Platycodon grandiflorum → one dispersing and one descending, restoring the function of lung qi dispersion and descent, fitting the pathogenesis of stagnant lung qi on the plateau.

[0023] Loquat leaf + Magnolia flower bud → both clearing the lung and relieving cough and dredging the nasal orifice, improving respiratory symptoms.

[0024] 3) Spleen-strengthening and dampness-resolving group (for dampness-turbidity obstructing the spleen on the plateau)

[0025] Atractylodes macrocephala: strengthening the spleen and replenishing qi, drying dampness and promoting diuresis → enhancing the spleen transportation function, preventing endogenous dampness-turbidity; strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating.

[0026] Agastache rugosa: aromatically resolving dampness, regulating the stomach and stopping vomiting → awakening the spleen and resolving turbidity, preventing dampness from obstructing the spleen and stomach on the plateau; dispelling summer heat and relieving exterior syndrome, resolving dampness and strengthening the spleen, regulating qi and harmonizing the stomach.

[0027] Amomum kravanh: warming the middle energizer and promoting qi movement, promoting digestion and increasing appetite → assisting digestion, preventing anorexia and abdominal distension on the plateau; resolving dampness and promoting qi movement, warming the middle energizer and stopping vomiting, promoting digestion and increasing appetite.

[0028] Isatis root: clearing heat and detoxifying, relieving sore throat → preventing sore throat caused by heat transformation of cold on the plateau; clearing heat and detoxifying, cooling blood and relieving sore throat.

[0029] Atractylodes macrocephala + Pogostemon cablin → Promote both spleen strengthening and dampness elimination, and improve the retention of damp-turbidity in the plateau region.

[0030] Amomum kravanh + Isatis tinctoria → Warm the middle-jiao and promote qi movement, and prevent depressive heat at the same time, which is in line with the characteristics of cold-heat complexity in the plateau region.

[0031] 4) Plateau-specific synergistic mechanism

[0032] Enhance the external defensive function (Saposhnikovia divaricata + Astragalus membranaceus + Schizonepeta tenuifolia) → Improve the disease resistance of the body in the plateau hypoxic environment.

[0033] Regulate the ascending and descending of lung qi (Prunus armeniaca var. ansu + Platycodon grandiflorum + Eriobotrya japonica) → Improve cough and asthma caused by the stagnation of lung qi in the plateau region.

[0034] Strengthen the spleen and resolve dampness to prevent disease progression (Atractylodes macrocephala + Pogostemon cablin + Amomum kravanh) → Block the transmission trend of damp pathogens from the exterior to the interior in the plateau region.

[0035] Preferably, the weight unit of each raw material is gram, specifically: Schizonepeta tenuifolia 10g, Saposhnikovia divaricata 5g, Eriobotrya japonica 5g, Atractylodes macrocephala 15g, Prunus armeniaca var. ansu 10g, Platycodon grandiflorum 10g, Magnolia liliflora Desr. 10g, Isatis tinctoria 10g, Pogostemon cablin 15g, Perilla frutescens 10g, Amomum kravanh 5g, Astragalus membranaceus 5g.

[0036] A preparation method of a traditional Chinese medicine composition for treating mild plateau colds, comprising the following steps:

[0037] Step 1: Prepare various raw materials according to the ratio, and ensure that the quality of the raw materials meets the standards of the Chinese Pharmacopoeia;

[0038] Step 2: Crush and mix the raw materials weighed in Step 1, and prepare them into instant granules.

[0039] The application of a traditional Chinese medicine composition in the treatment of mild plateau colds.

[0040] In summary, due to the adoption of the above technical solutions, the beneficial effects of the present invention are:

[0041] This treatment plan can not only quickly relieve exterior syndromes such as nasal congestion, runny nose, cough, and sore throat, but also significantly shorten the overall course of disease (30%-50% shorter than conventional western medicine treatment) through multi-target effects such as regulating immune function, improving microcirculation, and enhancing antioxidant capacity. Western medicine treatment methods such as paracetamol, pseudoephedrine hydrochloride, and dextromethorphan hydrobromide oral solution can relieve single symptoms such as headache, fever, and cough to a certain extent, but due to their limitation of "treating the symptoms rather than the root cause", it often takes 7-10 days or even longer to control the symptoms. Clinical data show that about 10% of patients ultimately still need to rely on infusion treatment, and the recurrence rate after cure remains high. In addition, this treatment plan can also effectively inhibit the transformation from mild to severe cases and significantly reduce the disease recurrence rate.

[0042] Colds occurring in the plateau environment have significant particularities. The pathological characteristics of its pathogenesis present a complex situation of "external cold and internal stasis, deficiency and excess intertwined". The clinical syndromes show the image of "wind-cold attacking the exterior" with a slightly red tongue and thin white and slightly greasy tongue coating at the initial stage, and then develop into the characteristics of "yin fluid deficiency and dampness stagnation" with a dry and slightly moist tongue, accompanied by typical characteristics such as a lingering course of disease, being prone to heat transformation and transmission, and a high incidence in winter and spring seasons. In view of a series of pathological changes such as "weak defense yang, deficiency of lung and spleen qi, and abnormal distribution of body fluids" caused by the harsh environment of "high cold, low oxygen, wind, dryness, and dampness stagnation" unique to the plateau area, based on the overall concept of "harmony between man and nature" and the core theory of "treatment based on syndrome differentiation" in traditional Chinese medicine, the present invention innovatively proposes a systematic treatment plan of traditional Chinese medicine composition. By deeply grasping the core pathogenesis of "retention of pathogenic factors due to deficiency of healthy qi" in plateau colds, strictly following the treatment principle of "strengthening healthy qi and dispelling pathogenic factors, taking both the root and the branch into consideration", adopting the innovative formula strategy of "simultaneously applying exterior-releasing and root-strengthening methods, and promoting dispelling pathogenic factors and strengthening healthy qi", and scientifically compatibility of multiple Chinese medicinal materials with synergistic effects, it not only pays attention to dispersing wind-cold to dispel external pathogenic factors, but also emphasizes strengthening the spleen and nourishing the lung to protect the root, while taking into account auxiliary effects such as promoting blood circulation to remove stasis and resolving phlegm and dredging collaterals.

[0043] The traditional Chinese medicine composition for treating mild plateau colds provided by the present invention is developed based on the special pathological characteristics of mild colds in the plateau environment (such as a dry but slightly moist tongue surface, indicating deficiency of true yin while there is still surface body fluid), as well as the core theories in the theoretical system of traditional Chinese medicine, such as yin-yang and five elements, zang-fu organs and meridians, qi, blood and body fluids, and etiology and pathogenesis. The climate in the plateau area is cold and dry, with insufficient yang qi and excessive yin cold. Coupled with the combination of wind, cold, and damp pathogenic factors invading the human body, it is easy to cause external pathogenic factors to bind to the exterior and the lung defense function to be disordered, thus forming the pathological characteristics of qi stagnation in the lung. The lung is the uppermost zang-organ, responsible for respiration and the function of defending the exterior. It is externally combined with the skin and hair and opens into the nose. When external pathogenic factors invade in the initial stage, the lung defense function is disordered, the exterior defense is not solid, and the opening and closing of the skin and pores are abnormal, resulting in qi stagnation in the lung and the disorder of its normal dispersing and descending functions, and then a pathological state of qi stagnation and abnormal distribution of body fluids appears. This traditional Chinese medicine composition aims at the pathological characteristics of external pathogenic factors invading in the initial stage and qi stagnation in the lung in mild plateau colds, with the treatment principles of dispersing lung qi and relieving the exterior, dispelling pathogenic factors and moistening dryness, and regulating nutrient qi and defensive qi. Following the compatibility principle of monarch, minister, assistant, and envoy, it selects drugs with the effects of dispersing pathogenic factors with pungent-cool herbs, moistening the lung and promoting the production of body fluids, and dispersing wind-cold, such as Schizonepeta tenuifolia, Saposhnikovia divaricata, Eriobotrya japonica leaves, and Armeniaca vulgaris, etc., to disperse external pathogenic factors, ventilate the lung qi, and moisten dryness and promote the production of body fluids. At the same time, the formula takes into account regulating the spleen and stomach to help the source of qi and blood production, enhance the body's disease resistance, and prevent further invasion of external pathogenic factors. Compared with western medicine, this traditional Chinese medicine composition not only has a more significant curative effect and a shorter treatment cycle, but also can effectively block the pathological process of mild plateau colds developing from mild to severe through the effects of strengthening healthy qi and dispelling pathogenic factors, and regulating yin and yang, and prevent the occurrence of pathological changes such as internal transmission of pathogenic factors and mutual binding of phlegm and stasis. In addition, this formula pays attention to overall regulation, can not only relieve symptoms, but also improve the state of deficiency of healthy qi in patients, reflecting the concepts of preventing disease in traditional Chinese medicine and treating both the symptoms and the root cause, and has important clinical significance and promotion value. Detailed implementation mode

[0044] To clearly illustrate the purpose, technical solution and advantages of the present invention, the technical solution of the present invention will be described in detail below in conjunction with specific embodiments. It should be noted that the following embodiments are only partial embodiments of the present invention, not all of them.

[0045] Example

[0046] A traditional Chinese medicine composition for treating mild colds at high altitudes is composed of the following raw materials in the following weight ratios: 10 g of Schizonepeta tenuifolia Briq., 5 g of Saposhnikovia divaricata (Turcz.) Schischk., 5 g of Eriobotrya japonica (Thunb.) Lindl., 15 g of Atractylodes macrocephala Koidz., 10 g of Armeniaca vulgaris Lam., 10 g of Platycodon grandiflorus (Jacq.) A. DC., 10 g of Magnolia liliflora Desr., 10 g of Isatis tinctoria L., 15 g of Pogostemon cablin (Blanco) Benth., 10 g of Perilla frutescens (L.) Britt., 5 g of Amomum kravanh Pierre ex Gagnep., and 5 g of Astragalus membranaceus (Fisch.) Bunge.

[0047] The total weight of the raw materials for the medicine is 110 g, and after being prepared into decoction-free granules according to the standards of the National Medical Products Administration, the weight is 33 g. Patients take 11 g three times a day.

[0048] Animal experiments

[0049] 75 8-week-old BALB / c mice (purchased from Sichuan Dashuo Company), with an average weight of (26 ± 2.3) g, were raised at a temperature of (20 ± 2) °C and a humidity of (40 ± 5)%, and the animal illuminance was 15 - 20 lx. Under the condition that the day-night light-dark alternation time is generally 12 - 14 hours during the day and 12 - 10 hours at night, they were randomly divided into a normal control treatment group, a cold model group, a complete formula group (I), a schizonepeta tenuifolia briq. deficiency group (II), a saposhnikovia divaricata (turcz.) schischk. deficiency group (III), an eriobotrya japonica (thunb.) lindl. deficiency group (IV), an atractylodes macrocephala koidz. deficiency group (V), an armeniaca vulgaris lam. deficiency group (VI), a platycodon grandiflorus (jacq.) a. dc. deficiency group (VII), a magnolia liliflora desr. deficiency group (VIII), an isatis tinctoria l. deficiency group (IX), a pogostemon cablin (blanco) benth. deficiency group (X), a perilla frutescens (l.) britt. deficiency group (XI), an amomum kravanh pierre ex gagnep. deficiency group (XII), and an astragalus membranaceus (fisch.) bunge. deficiency group (XIII), with 5 mice in each group, as shown in Table 1 specifically:

[0050] Table 1 Grouping of mouse experiments

[0051]

[0052]

[0053] Pharmacodynamic experiments were carried out on the traditional Chinese medicine compositions I to XIII prepared in Examples 1 - 13. The specific method is as follows:

[0054] Except for the normal control treatment group, the remaining groups were placed in a low-pressure and hypoxic chamber to simulate the plateau environment at an altitude of 3500 m (oxygen concentration 13.5%). The simulation conditions were a temperature of 22 ± 2 °C, a humidity of 50 ± 5%, and continuous exposure for 72 hours. After 24 hours of low-pressure exposure, the Puerto Rico / 8 virus strain at a concentration of 1 × 10^3 PFU / 20 μl was inoculated intranasally. The mice were allowed to eat and drink freely. After 4 days of continuous exposure, cold symptoms such as huddling, runny nose, aversion to cold (manifested as clustering behavior), and reduced activity appeared, successfully establishing a mouse model of mild cold in a plateau environment. The evaluation criteria for a successful model were physiological indicators: 1. Physiological indicators: blood oxygen saturation of 80 - 90%, weight loss ≤ 15%; 2. Behavioral: mild piloerection, 20 - 40% reduction in activity; 3. Pathology: mild thickening of the alveolar septum, IL-6 ≤ 200 pg / ml in BALF.

[0055] From the 5th day, the mice were transferred to a normal temperature environment for drug administration and related experimental operations; the normal control treatment group was raised under the same conditions for 7 days without any treatment. From the 5th day, the drug group was continuously administered by gavage for 3 days, and the normal control treatment group and the cold model group were given an equal volume of normal saline by gavage. During this period, the weight changes of the animals in each group were recorded. On the 8th day, blood was collected from the eyes of the mice in each group, and the organs were dissected. The surface blood of the organs was washed with 0.9% sodium chloride solution, the fascia on the surface of the organs was removed, and the moisture was blotted dry before weighing. The lung index was calculated (lung index = wet lung weight / body weight × 100%). The right lung tissue was homogenized to detect the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The anticoagulated blood samples were used for routine blood tests, including indicators such as white blood cell count and lymphocyte ratio.

[0056] Results of the pharmacodynamic study of animal experiments:

[0057] 1. Effects of changes in individual components of the traditional Chinese medicine treatment formula on the body weight of mice

[0058] The effects of changes in individual components of the traditional Chinese medicine treatment formula on body weight are shown in Table 2: Compared with the normal control treatment group, the body weight of the mice in the cold model group continued to decrease on the 5th and 8th days, and the difference was statistically significant (P < 0.05); compared with the cold model group, the body weight of the mice in the complete formula group (I) of the traditional Chinese medicine composition was close to the level of the normal control treatment group on the 8th day, and the difference was statistically significant (P < 0.05). The body weight of the mice in the schizonepeta absent group (II), ledebouriella absent group (III), and perilla leaf absent group (XI) of the traditional Chinese medicine composition continued to decrease on the 5th and 8th days, and the difference was statistically significant compared with the complete formula group (I) on the 8th day (P < 0.05). The body weight of the mice in the eriobotrya japonica absent group (IV), magnolia liliflora absent group (VIII), and isatis root absent group (IX) of the traditional Chinese medicine composition tended to be stable on the 8th day, and the difference was statistically significant compared with the complete formula group (I).

[0059] (P < 0.05). In the groups of mice lacking Atractylodes macrocephala (V), Armeniaca vulgaris (VI), Platycodon grandiflorus (VII), Pogostemon cablin (X), Amomum kravanh (XII), and Astragalus membranaceus (XIII) in the traditional Chinese medicine composition, the body weight of the mice increased on the 8th day, and there was no significant difference compared with the complete formula group (I) (P > 0.05).

[0060] Table 2. Effects of single-component changes in traditional Chinese medicine treatment formula on body weight of mice

[0061]

[0062] Note: Compared with the normal control treatment group, P < 0.05; compared with the model group, b P < 0.05; compared with the complete formula group, c P < 0.05

[0063] 2. Effects of single-component changes in traditional Chinese medicine treatment formula on lung weight and lung index of mice

[0064] The effects of single-component changes in the traditional Chinese medicine treatment formula on the lung weight and lung index of mice are shown in Table 3: Compared with the normal control treatment group, the lung weight and lung index of the mice in the cold model group increased, and the difference was statistically significant (P < 0.05); the lung weight and lung index of the mice in the complete formula group (I) of the traditional Chinese medicine composition were close to the levels of the normal control treatment group, and the difference was statistically significant compared with the model group (P < 0.05). The lung weight and lung index of the mice in the groups lacking Schizonepeta tenuifolia (II), Saposhnikovia divaricata (III), and Perilla frutescens (XI) in the traditional Chinese medicine composition increased, and the difference was statistically significant compared with the complete formula group (I) (P < 0.05). The lung weight and lung index of the mice in the groups lacking Eriobotrya japonica (IV), Magnolia liliflora (VIII), and Isatis indigotica (IX) in the traditional Chinese medicine composition tended to be stable, and the difference was statistically significant compared with the complete formula group (I) (P < 0.05). The lung weight and lung index of the mice in the groups lacking Atractylodes macrocephala (V), Armeniaca vulgaris (VI), Platycodon grandiflorus (VII), Pogostemon cablin (X), Amomum kravanh (XII), and Astragalus membranaceus (XIII) in the traditional Chinese medicine composition decreased, and there was no significant difference compared with the complete formula group

[0065] (P > 0.05).

[0066] Table 3. Effects of single-component changes in traditional Chinese medicine treatment formula on lung weight and lung index of mice

[0067] Group Lung weight (g) Lung index Normal control treatment group 0.17±0.02 0.63±0.07 Model group 0.23±0.015 1.05±0.06 Group I <![CDATA[0.15±0.008 b > <![CDATA[0.63±0.04 b > Group II <![CDATA[0.23±0.01 c > <![CDATA[1.07±0.04 c > Group III <![CDATA[0.2±0.011 c > <![CDATA[0.86±0.05 c <!-- 6 -->]]> Group IV <![CDATA[0.2±0.01 c > <![CDATA[0.84±0.04 c > Group V 0.16±0.02 0.65±0.06 Group VI 0.16±0.01 0.66±0.05 Group VII 0.16±0.02 0.66±0.05 Group VIII <![CDATA[0.18±0.01 c > <![CDATA[0.79±0.06 c > Group IX <![CDATA[0.18±0.01 c > <![CDATA[0.79±0.02 c > Group X 0.15±0.01 0.64±0.05 Group XI <![CDATA[0.23±0.001 c > <![CDATA[1.03±0.04 c > Group XII 0.15±0.013 0.64±0.05 Group XIII 0.15±0.01 0.63±0.04

[0068] Note: Compared with the normal control treatment group, P < 0.05; compared with the model group, b P < 0.05; compared with the complete formula group,c P < 0.05

[0069] 3. Effects of Single Component Change of Traditional Chinese Medicine Treatment Formula on Serum TNF-α and IL-6

[0070] The effects of single component change of traditional Chinese medicine treatment formula on serum TNF-α and IL-6 in mice are shown in Table 4: Compared with the normal control treatment group, the levels of serum TNF-α and IL-6 in the cold model group mice increased, and the difference was statistically significant (P < 0.05); Compared with the cold model group, the levels of serum TNF-α and IL-6 in the mice of the complete formula group (I) of traditional Chinese medicine composition returned to the normal control treatment group level on the 8th day, and the difference was statistically significant (P < 0.05). The levels of serum TNF-α and IL-6 in the mice of the schizonepeta absent group (II), ledebouriella absent group (III) and perilla leaf absent group (XI) of traditional Chinese medicine composition increased significantly, and the difference was statistically significant compared with the complete formula group (I) (P < 0.05). The levels of serum TNF-α and IL-6 in the eriobotrya japonica absent group (IV), magnolia liliflora absent group (VIII) and isatis root absent group (IX) of traditional Chinese medicine composition tended to be stable, and the difference was statistically significant compared with the complete formula group (I) (P < 0.05). The levels of serum TNF-α and IL-6 in the atractylodes macrocephala absent group (V), apricot kernel absent group (VI), platycodon grandiflorum absent group (VII), pogostemon cablin absent group (X), amomum kravanh absent group (XII) and astragalus membranaceus absent group (XIII) of traditional Chinese medicine composition decreased, and the difference was not statistically significant compared with the complete formula group (P > 0.05).

[0071] Table 4. Effects of Single Component Change of Traditional Chinese Medicine Treatment Formula on Serum TNF-α and IL-6

[0072] Group TNF-α (pg / mL) IL-6 (pg / mL) Normal control treatment group 10.44±0.68 15.38±0.57 Model group <![CDATA[26.08+1.07 a > <![CDATA[36.1±0.89 a > Group I <![CDATA[10.78±0.55 b > <![CDATA[15.46±0.86 b > Group II <![CDATA[25.36±1.28 c > <![CDATA[34.94±0.97 c > Group III <![CDATA[24.98±1.72 c > <![CDATA[35.18±1.32 c > Group IV <![CDATA[22.94±1.46 c > <![CDATA[32.76±2.01 c > Group V 14.1±3.33 20±4.13 Group VI 12.98±2.19 19.98±4.51 Group VII 14.62±3.59 20.06±4.07 Group VIII <![CDATA[21.4±2.94 c > <![CDATA[27.04±4.93 c > Group IX <![CDATA[23.46±1.72 c > <![CDATA[32.3±2.24 c > Group X 12.64±2.03 17.58±2.16 Group XI <![CDATA[27.78±1.11 c > <![CDATA[36.98±2.02 c > Group XII 11.98±0.84 16.7±1.54 Group XIII 11.24±0.75 17.02±1.93

[0073] Note: Compared with the normal control treatment group, a P < 0.05; Compared with the model group, b P < 0.05; Compared with the complete formula group, c P < 0.05

[0074] As can be seen from Tables 2 - 4, in the traditional Chinese medicine composition treatment formula for mild colds, each component plays a synergistic role and jointly constructs a multi-level treatment system for wind-cold colds, which is reflected in multiple aspects such as anti-inflammatory, immune regulation, and symptom relief. Among them, the components such as Schizonepeta tenuifolia, Saposhnikovia divaricata, Perilla frutescens, Eriobotrya japonica, Magnolia liliflora, and Isatis indigotica have particularly significant effects. These drugs play a core role in the formula and are key drugs for the main syndrome of wind-cold colds. Drugs such as Schizonepeta tenuifolia, Saposhnikovia divaricata, and Perilla frutescens relieve the respiratory tract inflammatory response by inhibiting the release of inflammatory factors (such as TNF-α, IL-6), thereby improving the symptoms of wind-cold colds. If these components are missing, it will not only affect the overall efficacy of the formula but also may cause significant changes in indicators such as body weight, lung weight, lung index, TNF-α, and IL-6, reflecting the imbalance of the body in inflammatory response and immune regulation (such as an increase in pro-inflammatory factor levels and a decrease in anti-inflammatory factor levels).

[0075] From the perspective of traditional Chinese medicine theory, drugs such as Schizonepeta tenuifolia, Saposhnikovia divaricata, and Perilla frutescens play a leading therapeutic role in the main syndrome of wind-cold colds and are indispensable core drugs in the formula. Schizonepeta tenuifolia is pungent and warm in nature, and belongs to the lung and liver meridians. It has the effects of expelling wind and relieving the exterior, promoting eruption and relieving itching. For the main syndrome of wind-cold attacking the exterior and disharmony of the defensive qi, it can disperse exogenous pathogenic factors, regulate the defensive qi, make the interstices smooth, and the pathogenic factors be expelled with sweating. Saposhnikovia divaricata is pungent and warm in nature, and belongs to the bladder, liver, and spleen meridians. It expels wind and relieves the exterior, dispels dampness and relieves pain, enhancing the effect of relieving the exterior. It is particularly effective in relieving wind-cold-damp arthralgia and limb pain. Perilla frutescens is pungent and warm in nature, and belongs to the lung and spleen meridians. It relieves the exterior and dispels cold, regulates qi and harmonizes the middle. It is suitable for wind-cold colds accompanied by cough and nausea. Its function of regulating qi and harmonizing the middle can also relieve qi stagnation in the spleen and stomach and regulate the qi movement in the middle jiao. Drugs such as Eriobotrya japonica, Magnolia liliflora, and Isatis indigotica play the role of assistant drugs in the formula, enhancing the effects of relieving the exterior and dispelling cold, clearing heat and detoxifying, and relieving cough and sore throat, for the concurrent syndromes of wind-cold colds accompanied by phlegm-heat and throat discomfort. Eriobotrya japonica is neutral in nature and bitter in taste, and belongs to the lung and stomach meridians. It has the effects of clearing the lung and relieving cough, harmonizing the stomach and promoting diuresis, and suppressing the adverse flow of qi and stopping vomiting. It can relieve cough and nausea caused by lung heat or stomach heat. Isatis indigotica is bitter and cold in nature, and belongs to the heart and stomach meridians. It clears heat and detoxifies, cools the blood and relieves sore throat. It is an important drug for treating sore throat and heat toxin congestion. Magnolia liliflora is pungent and warm in nature, and belongs to the lung and stomach meridians. It expels wind and cold, opens the orifices, and relieves upper respiratory tract symptoms such as nasal congestion. It is particularly effective in treating nasal sinusitis and nasal obstruction.

[0076] In addition, although components such as Atractylodes macrocephala, Armeniaca vulgaris, Pogostemon cablin, Platycodon grandiflorus, Amomum kravanh, and Astragalus membranaceus play a slightly less important role in the formula compared to the above core components, they also play an irreplaceable role. Drugs such as Atractylodes macrocephala, Amomum kravanh, and Pogostemon cablin mainly play the role of regulating the spleen and stomach, strengthening the vital qi, and relieving concurrent syndromes such as qi stagnation in the spleen and stomach and damp obstruction caused by exogenous wind-cold. Atractylodes macrocephala is sweet and warm, belonging to the spleen and stomach meridians, strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, regulating the spleen and stomach, and enhancing the body's vital qi. Amomum kravanh is pungent and warm, belonging to the spleen, stomach, and lung meridians, promoting qi circulation to eliminate dampness, warming the middle-jiao to stop vomiting, regulating the qi movement in the middle-jiao. Pogostemon cablin is pungent and warm, belonging to the spleen, stomach, and lung meridians, relieving the exterior and resolving dampness, regulating qi and harmonizing the middle-jiao, regulating the spleen and stomach, relieving the exterior and resolving dampness. Drugs such as Armeniaca vulgaris, Platycodon grandiflorus, and Astragalus membranaceus act as envoy drugs, guiding all the drugs to reach the affected site, regulating the properties of the drugs, enhancing the effects of relieving cough and asthma, and dispersing phlegm from the lung, and at the same time tonifying the vital qi. Armeniaca vulgaris is bitter and warm, belonging to the lung and large intestine meridians, descending qi to relieve cough and asthma, moistening the intestines and promoting defecation, and guiding the drug into the lung meridian. Platycodon grandiflorus is bitter, pungent, and neutral, belonging to the lung meridian, dispersing phlegm from the lung, relieving sore throat and discharging pus, guiding the drug into the lung meridian, and regulating the qi of the lung. Astragalus membranaceus is sweet and warm, belonging to the spleen and lung meridians, replenishing qi and raising yang, consolidating the exterior to stop sweating, enhancing the body's vital qi, and guiding the drug into the spleen and lung.

[0077] To sum up, through the reasonable compatibility of monarch, minister, assistant, and envoy drugs, this formula comprehensively treats the main syndrome and concurrent syndromes of wind-cold cold. The synergistic effect of each component not only dispels pathogenic factors and relieves the exterior, but also strengthens the healthy qi and consolidates the root, regulates the functions of the zang-fu organs, enabling the formula to take into account both the symptoms and root causes in the treatment of mild colds, achieving the treatment goal of dispelling pathogenic factors without harming the healthy qi and strengthening the healthy qi without leaving pathogenic factors.

[0078] Clinical trials

[0079] The traditional Chinese medicine composition described in the embodiment was used for clinical trials. The following are the processes and test result data of the clinical trials:

[0080] 1. Test subjects: A total of 200 patients were included in this test. The patients had lived in the high-altitude area (areas above 4000 meters above sea level in Litang and Batang areas of Sichuan Province) for ≥ 3 months, including 110 males and 90 females. The age range of the patients was 18 - 66 years old, and the average age was 38.74 ± 9.74 years.

[0081] 2. Inclusion criteria:

[0082] 1) Meeting the diagnostic criteria for mild cold in the "Expert Consensus on Standard Diagnosis and Treatment of Common Cold" of the Chinese Medical Doctor Association;

[0083] 2) Age ≥ 18 years old;

[0084] 3) The time from the onset of cold symptoms to seeking medical treatment ≤ 48 hours.

[0085] 3. Exclusion criteria:

[0086] 1) Having combined diseases such as pneumonia, bronchitis, otitis media, angina, viral myocarditis, acute nephritis, rheumatic arthritis, etc.;

[0087] 2) Combined hepatic and renal insufficiency;

[0088] 3) A history of clear allergy to the drug components of antiviral oral liquid;

[0089] 4) Pregnant or lactating women;

[0090] 5) Suspected severe or critical influenza patients;

[0091] 6) Spleen and stomach deficiency-cold accompanied by diarrhea;

[0092] 7) Unable to cooperate with the completion of clinical observation due to intellectual or behavioral disorders;

[0093] 8) Currently participating or having participated in other clinical studies of cold medicines within 1 month before treatment;

[0094] 9) Those who have taken other cold prevention and treatment drugs within 48 hours before enrollment;

[0095] 10) Other patients who the researcher judges as not suitable to participate in this study.

[0096] 4. Test method:

[0097] The visiting patients were randomly divided into a general experimental group, a combined treatment experimental group, and a control treatment group. There were 40 people in the general experimental group, 72 people in the combined treatment experimental group, and 88 people in the control treatment group. Among them, there were 51 males and 37 females in the control treatment group; 25 males and 15 females in the general experimental group; 41 males and 31 females in the combined treatment group. The control treatment group used western medicine alone for treatment. The western medicine treatment plan was as follows: One or more of the following drugs could be combined: Paracetamol and Chlorphenamine Maleate Capsules (Baiyunshan Tangyin Dongtai Pharmaceutical Co., Ltd., 3 times a day, 2 capsules each time); Dexamethorphan Hydrobromide Oral Solution (Lianbang Pharmaceutical Co., Ltd., 3 times a day, 10 mL each time); Compound Paracetamol and Amantadine Hydrochloride Tablets (Jilin Changbai Mountain Pharmaceutical Co., Ltd., 2 times a day, 1 tablet each time); Ibuprofen Tablets (Zhongsheng Pharmaceutical Co., Ltd., 2 tablets each time. If the pain or fever persists, the drug can be repeated once every 4 - 6 hours, and the dosage within 24 hours should not exceed 4 times). One or more of the above western medicines were selected according to the different conditions of different patients.

[0098] The general treatment group used the traditional Chinese medicine composition of Example 1 for treatment. The treatment plan was to take the traditional Chinese medicine composition of Example 1 by boiling it with boiling water in the form of free-decoction granules (Yifang Pharmaceutical Co., Ltd.), 3 times a day, 11 grams each time.

[0099] The combined treatment group used the traditional Chinese medicine composition of Example 1 combined with western medicine for treatment. The treatment plan was to take the traditional Chinese medicine composition of Example 1 by boiling it with boiling water in the form of free-decoction granules (Yifang Pharmaceutical Co., Ltd.), 3 times a day, 11 grams each time. At the same time, one or several of Paracetamol and Chlorphenamine Maleate Capsules, Dexamethorphan Hydrobromide Oral Solution, Compound Paracetamol and Amantadine Hydrochloride Tablets, and Ibuprofen Tablets were added according to the actual situation.

[0100] 5. Observation indicators:

[0101] Subjective evaluations of the efficacy of the traditional Chinese medicine composition by patients in the conventional treatment group and the combined treatment group were divided into "better", "comparable", or "worse". The time required for complete disappearance of symptoms.

[0102] 6. Efficacy evaluation criteria:

[0103] Cured: Symptoms, signs, laboratory tests, and specific indicators all returned to normal after 3 days of treatment;

[0104] Markedly effective: One item among symptoms, signs, laboratory tests, and specific indicators did not return to normal after 3 days of treatment;

[0105] Effective: Two items among symptoms, signs, laboratory tests, and specific indicators did not return to normal after 3 days of treatment;

[0106] Ineffective: No improvement or deterioration after 3 days of treatment.

[0107] Effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0108] Record adverse drug reactions, including mild dizziness, fatigue, nausea, upper abdominal discomfort, loss of appetite, vomiting, diarrhea, abdominal pain, etc.

[0109] 7. Experimental results

[0110] (1) Clinical efficacy evaluation

[0111] The results are shown in Table 5. In the conventional treatment group, 75.0% of the patients believed that the efficacy of the traditional Chinese medicine composition in treating common cold was better than that of western medicine, 20.0% of the patients thought they were comparable, and 5.0% of the patients thought the efficacy of the traditional Chinese medicine composition was worse than that of western medicine. In the combined treatment group, 88.9% of the patients believed that the efficacy of the combined treatment for common cold was better than that of western medicine, and this proportion was significantly higher than that of using the traditional Chinese medicine composition alone (P < 0.05), 4.2% of the patients thought they were comparable, and 6.9% of the patients thought the efficacy of the combined treatment was worse than that of western medicine.

[0112] Table 5. Subjective evaluations of the efficacy of traditional Chinese medicine or combined traditional Chinese and western medicine treatment in patients with mild colds

[0113]

[0114] (2) Number of days required for complete remission of cold symptoms

[0115] As shown in Table 6, the number of days for the complete disappearance of symptoms such as cough, expectoration, nasal congestion, runny nose, pharyngeal discomfort, and headache in the conventional treatment group and the combined treatment group was significantly shorter than that in the western medicine treatment group, and the difference was statistically significant (P<0.01). There was no statistically significant difference in the number of days for the complete disappearance of symptoms such as cough, expectoration, nasal congestion, runny nose, pharyngeal discomfort, and headache between the traditional Chinese medicine treatment group and the combined traditional Chinese and western medicine treatment group (P>0.05).

[0116] Table 6. Number of days for complete remission of cold symptoms after treatment with traditional Chinese medicine, western medicine, or combined traditional Chinese and western medicine

[0117]

[0118] Data are expressed as mean ± standard deviation; P 1 , conventional treatment group vs control treatment group; P 2 , combined treatment group vs control treatment group;

[0119] P 3 , combined treatment group vs conventional treatment group

[0120] 3. Comprehensive evaluation of curative effect

[0121] As shown in Table 7, on the 3rd day after the start of treatment, there were 38 effective cases, 2 markedly effective cases, and 0 cured cases in the control treatment group, and the total effective rate was 45.5% (total effective rate = (number of effective cases + number of markedly effective cases + number of cured cases) / total number of cases × 100%); there was 1 effective case, 10 markedly effective cases, and 28 cured cases in the conventional treatment group, and the total effective rate was 97.5%; there were 0 effective cases, 30 markedly effective cases, and 42 cured cases in the combined treatment group, and the total effective rate was 100%. The chi-square test was used to compare the total effective rates between groups. The total effective rates of the traditional Chinese medicine treatment group and the combined traditional Chinese and western medicine treatment group were compared with that of the western medicine treatment group respectively, and the differences were statistically significant (P<0.001):

[0122] Table 7. Comprehensive curative effects of western medicine, traditional Chinese medicine, or combined traditional Chinese and western medicine treatment

[0123]

[0124] Total effective rate: (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%. P 总有效率 : conventional treatment group or combined treatment group vs control treatment group.

[0125] 4. Adverse drug reactions

[0126] As shown in Table 8, 1 case of adverse drug reaction (diarrhea) occurred in the western medicine treatment group, and no obvious adverse drug reactions were seen in other groups.

[0127] Table 8. Adverse drug reactions

[0128]

[0129] As can be seen from Tables 5 - 8:

[0130] The traditional Chinese medicine treatment formula or the combined treatment of traditional Chinese and Western medicines has significant curative effects on mild colds in high - altitude environments and few adverse reactions. This formula contains traditional Chinese medicinal materials such as Schizonepeta tenuifolia, Saposhnikovia divaricata, Pogostemon cablin, and Prunus armeniaca var. ansu. Its formula principle is closely related to the qi, blood, body fluid, zang - fu organs, and meridians of the human body, fully reflecting the core concepts of "treatment based on syndrome differentiation" and "strengthening the healthy qi and eliminating pathogenic factors" in traditional Chinese medicine. Wind - cold cold is caused by the invasion of cold pathogens into the muscle surface, the stagnation of defensive yang, the failure of the lung qi to disperse, resulting in the stagnation of qi movement and the coagulation of body fluid, thus presenting symptoms such as aversion to cold, fever, absence of sweating, nasal congestion and runny nose, cough, etc. This is the pathological mechanism of "external pathogens invading the lung and the lung losing its dispersing and descending functions", just as stated in "Huangdi Neijing": "The lung governs the skin and hair, opens into the nose, externally combines with the Taiyang meridian. When wind - cold attacks the exterior, the lung qi fails to disperse, so the above - mentioned symptoms appear." Schizonepeta tenuifolia is warm in nature and pungent in taste, belonging to the lung and liver meridians, with the effects of expelling wind and relieving the exterior, and promoting eruption and relieving itching; Saposhnikovia divaricata is slightly warm in nature, sweet and pungent in taste, belonging to the bladder, liver, and spleen meridians, which can expel wind and relieve the exterior, dispel dampness and relieve pain, and stop convulsions. The combination of the two, with pungent - warm dispersion, expels wind and cold. Their synergistic effect can make the defensive yang stretch, the interstices of the skin become loose, and the lung qi can be smoothly dispersed, thereby enhancing the body's ability to resist external pathogens and preventing the further aggravation of cold symptoms. Huoxiang Zhengqi - type preparations are classic prescriptions in traditional Chinese medicine, with a delicate formula, containing the wisdom of "resolving the exterior and interior simultaneously". In the formula, Pogostemon cablin is pungent, warm, and aromatic, belonging to the spleen, stomach, and lung meridians, with the effects of expelling wind - cold, resolving dampness, regulating qi and harmonizing the middle - jiao, which can aromatically remove turbidity, awaken the spleen and promote appetite, and regulate the qi movement in the middle - jiao; combined with other drugs, it can relieve the exterior pathogen, resolve interior dampness, enable the spleen and stomach to rise and fall in an orderly manner, and the qi movement to be smooth. For colds with cold and dampness or gastrointestinal colds, it has significant curative effects and can quickly relieve the symptoms of patients. Prunus armeniaca var. ansu is bitter in taste, warm in nature, belonging to the lung and large intestine meridians, with the effects of lowering qi, relieving cough and asthma, and moistening the intestines and promoting defecation. Its bitter and warm properties can lower the lung qi, relieve cough and asthma, and moisten the intestines and promote defecation, enabling the qi movement of the lung and large intestine to be smooth. In clinical applications, Prunus armeniaca var. ansu is often combined according to syndromes and used for various cough and asthma diseases. It is an excellent medicine for moistening the lung, eliminating phlegm, and relieving cough. Its mechanism of action lies in lowering the lung qi with bitterness, so that the lung qi descends, the qi movement is smooth, phlegm - dampness is transformed, and thus the effect of relieving cough and asthma is achieved. Just as stated in "Compendium of Materia Medica": "Apricot kernels can disperse and descend, so they can lower qi, relieve cough and asthma."

[0131] The above embodiments are only specific implementation manners of the present application. Those skilled in the art can make appropriate modifications or improvements without departing from the concept of the technical solution of the present application, and these modifications or improvements should all fall within the protection scope of the present application.

Claims

1. A Chinese medicine composition for treating mild high altitude cold, characterized in that: It is composed of the following raw materials in parts by weight: 10 parts of Schizonepeta, 5 parts of Saposhnikovia divaricata, 5 parts of Eriobotrya japonicae, 15 parts of Atractylodes macrocephala, 10 parts of Apricot kernel, 10 parts of Platycodon grandiflorum, 10 parts of Flos Magnoliae, 10 parts of Radix Isatidis, 15 parts of Patchouli, 10 parts of Folium Perillae, 5 parts of White Cardamoms, and 5 parts of Radix Astragali.

2. The Chinese medicine composition for treating mild high altitude cold according to claim 1, characterized in that: The weight unit of each raw material is gram, specifically: 10g of Schizonepeta, 5g of Saposhnikovia, 5g of loquat leaf, 15g of Atractylodes, 10g of Apricot, 10g of Platycodon, 10g of Magnolia, 10g of Isatis root, 15g of Patchouli, 10g of Perilla leaf, 5g of White Cardamom, and 5g of Astragalus.

3. A method for preparing the Chinese medicine composition for treating mild high altitude cold according to any one of claims 1 to 2, characterized in that: The following steps are involved: Step 1: weigh the raw materials according to the weight ratio of claim 1 or 2; Step 2: Crush and mix the raw materials weighed in step 1 and prepare them into fry-free granules.

4. Use of the Chinese medicine composition according to any one of claims 1 to 2 in treating mild high altitude colds.

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