Piezoelectric hydrogel composition, piezoelectric hydrogel and application of piezoelectric hydrogel

Abstract

The invention belongs to the technical field of functional materials, and particularly relates to a piezoelectric hydrogel composition, piezoelectric hydrogel and application thereof. The piezoelectric hydrogel composition provided by the invention takes the trimethylamine N-oxide (TMAO) with a zwitterionic structure as a polymeric monomer, and the TMAO has excellent antibacterial property and lubricity, also has close positive and negative charges, shows excellent hydration and antifouling ability, and is relatively low in immunogenicity. After the piezoelectric hydrogel composition provided by the invention is photo-cured, TMAO is polymerized to form PTMAO hydrogel, and the PTMAO hydrogel has a piezoelectric effect, so that rapid repair of inflammation is promoted. The PTMAO hydrogel can generate current through tooth movement and oral friction, so that wound healing is accelerated, and oral health is promoted. Through interaction of positive and negative charges and hydration, the piezoelectric hydrogel composition can form a protective layer on the surface of a tooth socket, inhibit bacterial attachment and contribute to repair of periodontitis.

Description

Technical Field

[0001] The present invention relates to the technical field of functional materials, and particularly relates to a piezoelectric hydrogel composition, a piezoelectric hydrogel and their applications. Background Art

[0002] During orthodontic treatment, patients often suffer from oral bacterial infections or minor wounds due to the friction and wear of dental braces. Traditional treatment methods usually rely on drugs and regular care, but these methods have limited effects and cannot provide antibacterial and anti-inflammatory effects in real time. In addition, the coating materials of traditional dental braces usually use non-bioactive materials or simple hydrophilic materials, and these materials have poor antibacterial properties. Summary of the Invention

[0003] In view of this, the purpose of the present invention is to provide a piezoelectric hydrogel composition, a piezoelectric hydrogel and their applications. The piezoelectric hydrogel formed by the piezoelectric hydrogel composition provided by the present invention has strong antibacterial properties.

[0004] In order to achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0005] The present invention provides a piezoelectric hydrogel composition, which includes a polymerization monomer, a crosslinking agent, a photoinitiator and water. The polymerization monomer is trimethylamine N-oxide, and the crosslinking agent is a photosensitive crosslinking agent.

[0006] Preferably, the preparation method of the trimethylamine N-oxide includes the following steps:

[0007] Dissolve diethylenetriaminepentaacetic acid in water to obtain a diethylenetriaminepentaacetic acid solution;

[0008] Add hydrogen peroxide and dimethylaminopropylacrylamide to the diethylenetriaminepentaacetic acid solution in sequence, and carry out a reaction to obtain the trimethylamine N-oxide.

[0009] Preferably, the concentration of the diethylenetriaminepentaacetic acid solution is 10 - 30 mg / mL;

[0010] The mass concentration of the hydrogen peroxide is 30 - 50%;

[0011] The molar amount of hydrogen peroxide in the hydrogen peroxide is 0.2 - 2 times the molar amount of dimethylaminopropylacrylamide;

[0012] The molar ratio of the diethylenetriaminepentaacetic acid to the dimethylaminopropylacrylamide is 1:10 - 1:30.

[0013] Preferably, adding hydrogen peroxide and dimethylaminopropyl acrylamide into the diethylenetriaminepentaacetic acid solution in sequence includes: adding hydrogen peroxide into the diethylenetriaminepentaacetic acid solution, and after adding the hydrogen peroxide, heating to the reaction temperature under the atmosphere of oxygen, and then adding the dimethylaminopropyl acrylamide; the dimethylaminopropyl acrylamide is used in the form of an aqueous solution of dimethylaminopropyl acrylamide, and the addition of the aqueous solution of dimethylaminopropyl acrylamide is completed within 30 min.

[0014] Preferably, the reaction temperature is 50-70 °C and the time is 5-12 h.

[0015] Preferably, the photosensitive crosslinking agent is an acrylamide compound, and the acrylamide compound includes one or more of N,N-methylenebisacrylamide, N,N-dimethylacrylamide, N-isopropylacrylamide, and methacrylamide.

[0016] Preferably, the photoinitiator is lithium phenyl(2,4,6-trimethylbenzoyl)phosphate or 2-hydroxy-2-methyl-1-phenylpropan-1-one.

[0017] Preferably, the molar ratio of water, polymerization monomer, crosslinking agent, and photoinitiator is 4000-5000:500-1000:5-20:1.

[0018] The present invention also provides a piezoelectric hydrogel, which is prepared by spraying and photocuring the piezoelectric hydrogel composition described in the above technical solution. The wavelength of the light source for photocuring is 245 nm-700 nm, and the power is 3 W-50 W.

[0019] The present invention also provides the application of the piezoelectric hydrogel composition described in the above technical solution or the piezoelectric hydrogel described in the above technical solution in the preparation of biomaterials.

[0020] The present invention provides a piezoelectric hydrogel composition.

[0021] In the piezoelectric hydrogel composition of the present invention, trimethylamine N-oxide (TMAO) having an amphoteric ion structure is used as a polymerization monomer. TMAO shows better effects than traditional hydrophilic materials in terms of antibacterial and lubricating properties. At the same time, TMAO has nearly equal positive and negative charges, showing excellent hydration, antifouling ability, and low immunogenicity. After the piezoelectric hydrogel composition provided by the present invention is photocured, TMAO polymerizes to form a PTMAO hydrogel. As a polymer, the change in the charge state of the PTMAO hydrogel will cause the chain structure to twist or stretch, thereby generating a piezoelectric effect, that is, the PTMAO hydrogel can generate an electric current through tooth movement and oral friction, and then accelerate wound healing, promote the rapid repair of inflammation, promote oral health, and bring a breakthrough improvement to orthodontic treatment. The interaction between positive and negative charges and the hydration effect enable the PTMAO hydrogel formed on the surface of the dental appliance by the piezoelectric hydrogel composition to exist in the form of a protective layer, thereby inhibiting the attachment of bacteria or proteins and contributing to the repair of periodontal inflammation. In addition, using trimethylamine N-oxide as a polymerization monomer, the formed piezoelectric hydrogel has good biocompatibility. Generally speaking, compared with traditional materials, the PTMAO hydrogel can not only provide lubrication, anti-protein adhesion, and anti-inflammatory effects in real time, but also has piezoelectric properties.

[0022] Furthermore, the present invention defines that the molar ratio of water, polymerization monomer, crosslinking agent, and photoinitiator in the piezoelectric hydrogel composition is 4000 - 5000:500 - 1000:5 - 20:1, making the piezoelectric hydrogel composition a sprayable material. Different from traditional coating materials that require complex processing and fixing methods, the piezoelectric hydrogel composition of the present invention can be quickly coated on the surface of dental appliances or other medical devices by spraying. After photocuring, rapid prototyping can be achieved, which not only reduces the complexity of the operation process but also ensures the uniformity and stability of the hydrogel in a short time. In addition, the sprayability of the piezoelectric hydrogel composition enables it to be applied to various surfaces, such as medical supplies, coatings, and sealants.

[0023] The present invention also provides a piezoelectric hydrogel, which is prepared by spraying and photocuring the piezoelectric hydrogel composition described in the above technical solution. The piezoelectric hydrogel of the present invention has stable performance, excellent piezoelectric properties, generates microcurrents through tooth movement and oral friction, has an anti-inflammatory effect, and promotes the healing of oral wounds. At the same time, it can automatically generate an electric current under repeated compression, effectively stimulating local cells at the wound surface and accelerating wound healing. Moreover, the piezoelectric hydrogel of the present invention has good lubricity and antibacterial properties, and can improve the lubricity and antibacterial properties of the biological interface. Description of the Drawings

[0024] Figure 1 Scanning electron microscope photograph of the piezoelectric hydrogel obtained in Example 2;

[0025] Figure 2 Storage modulus and loss modulus diagrams of the piezoelectric hydrogel obtained in Example 2;

[0026] Figure 3 Open-circuit voltage diagram of the piezoelectric hydrogel obtained in Example 2 under a pressure of 10 N;

[0027] Figure 4 Microscopic diagram (a) of the polyurethane-coated piezoelectric hydrogel obtained in Example 2, and fluorescence diagrams of anti-protein adsorption before (b) and after (c) spraying the hydrogel on the polyurethane surface. Detailed implementation manners

[0028] The present invention provides a piezoelectric hydrogel composition, comprising a polymerizable monomer, a crosslinking agent, a photoinitiator and water, wherein the polymerizable monomer is trimethylamine N-oxide, and the crosslinking agent is a photosensitive crosslinking agent.

[0029] The piezoelectric hydrogel composition provided by the present invention comprises a polymerizable monomer, and the polymerizable monomer is trimethylamine N-oxide (TMAO). In the present invention, the preparation method of the trimethylamine N-oxide preferably comprises the following steps:

[0030] Dissolve diethylenetriaminepentaacetic acid in water to obtain a diethylenetriaminepentaacetic acid solution;

[0031] Sequentially add hydrogen peroxide and dimethylaminopropylacrylamide to the diethylenetriaminepentaacetic acid solution and carry out a reaction to obtain the trimethylamine N-oxide.

[0032] In the present invention, diethylenetriaminepentaacetic acid is dissolved in water to obtain a diethylenetriaminepentaacetic acid solution. In the present invention, the water is preferably ultrapure water. In the present invention, the concentration of the diethylenetriaminepentaacetic acid solution is preferably 10 - 30 mg / mL, specifically preferably 10 mg / mL, 15 mg / mL, 20 mg / mL, 25 mg / mL or 30 mg / mL.

[0033] After obtaining the diethylenetriaminepentaacetic acid solution, the present invention sequentially adds hydrogen peroxide and dimethylaminopropylacrylamide to the diethylenetriaminepentaacetic acid solution for reaction to obtain the trimethylamine N-oxide. In the present invention, the mass concentration of the hydrogen peroxide is preferably 30-50%, specifically preferably 30%, 35%, 40%, 45% or 50%. In the present invention, the molar amount of hydrogen peroxide in the hydrogen peroxide is preferably 0.2-2 times the molar amount of dimethylaminopropylacrylamide, specifically preferably 0.2 times, 0.3 times, 0.4 times, 0.45 times, 0.5 times, 0.6 times, 0.7 times, 0.8 times, 0.9 times, 1 time, 1.1 times, 1.2 times, 1.3 times, 1.4 times, 1.5 times, 1.6 times, 1.7 times, 1.8 times, 1.9 times or 2 times. In the present invention, the molar ratio of diethylenetriaminepentaacetic acid to dimethylaminopropylacrylamide is preferably 1:10-1:30, specifically preferably 1:10, 1:15, 1:20, 1:25 or 1:30.

[0034] In the present invention, sequentially adding hydrogen peroxide and dimethylaminopropylacrylamide to the diethylenetriaminepentaacetic acid solution preferably includes: adding hydrogen peroxide to the diethylenetriaminepentaacetic acid solution, and after the addition of the hydrogen peroxide, heating to the reaction temperature in an oxygen atmosphere and adding the dimethylaminopropylacrylamide. In the present invention, the dimethylaminopropylacrylamide is preferably used in the form of an aqueous solution of dimethylaminopropylacrylamide, and the aqueous solution of dimethylaminopropylacrylamide is preferably added within 30 minutes. In the present invention, the concentration of the aqueous solution of dimethylaminopropylacrylamide is preferably 1-3 mg / mL, specifically preferably 1 mg / mL, 1.4 mg / mL, 1.5 mg / mL, 2 mg / mL, 2.5 mg / mL or 3 mg / mL.

[0035] In the present invention, the reaction temperature is preferably 50-70 °C, specifically preferably 50 °C, 55 °C, 60 °C, 65 °C or 70 °C; the time is preferably 5-12 h, specifically preferably 5 h, 6 h, 7 h, 8 h, 9 h, 10 h, 11 h or 12 h; the reaction time preferably starts to be counted after the addition of the dimethylaminopropylacrylamide is completed.

[0036] After the reaction, the present invention preferably further includes: naturally cooling the obtained reaction liquid to room temperature, and then sequentially performing extraction, washing and rotary evaporation to obtain the trimethylamine N-oxide. In the present invention, the extraction reagent is preferably dichloromethane, ethyl acetate or chloroform. In the present invention, the washing reagent is preferably an aqueous solution of sodium chloride or an aqueous solution of sodium carbonate. The present invention does not specifically limit the parameters of the rotary evaporation as long as the excess solvent can be removed.

[0037] In the present invention, trimethylamine N-oxide (TMAO) exhibits better effects than traditional hydrophilic materials in terms of antibacterial and lubricating properties; at the same time, TMAO has nearly equal positive and negative charges, showing excellent hydration, antifouling ability, and low immunogenicity.

[0038] The piezoelectric hydrogel composition provided by the present invention includes a cross-linking agent, and the cross-linking agent is a photosensitive cross-linking agent. The photosensitive cross-linking agent is preferably an acrylamide compound, and the acrylamide compound preferably includes one or more of N,N-methylenebisacrylamide, N,N-dimethylacrylamide, N-isopropylacrylamide, and methacrylamide. In the present invention, the cross-linking agent can polymerize the polymerization monomer TMAO to form a PTMAO hydrogel.

[0039] The piezoelectric hydrogel composition provided by the present invention includes a photoinitiator, and the photoinitiator is preferably lithium phenyl(2,4,6-trimethylbenzoyl)phosphate or 2-hydroxy-2-methyl-1-phenylpropan-1-one, and more preferably lithium phenyl(2,4,6-trimethylbenzoyl)phosphate.

[0040] The piezoelectric hydrogel composition provided by the present invention includes water, and the water is preferably ultrapure water.

[0041] In the present invention, the molar ratio of water, polymerization monomer, cross-linking agent, and photoinitiator in the piezoelectric hydrogel composition is preferably 4000 - 5000:500 - 1000:5 - 20:1, and specifically preferably 4900:515:9:1, 4900:691:9:1, or 4900:514:14:1.

[0042] In the present invention, the preparation method of the piezoelectric hydrogel composition preferably includes the following steps: mixing the polymerization monomer, cross-linking agent, photoinitiator, and water to obtain the piezoelectric hydrogel composition; the present invention does not make specific limitations on the mixing method, as long as the four materials can be fully mixed.

[0043] In the present invention, the piezoelectric hydrogel composition is preferably stored under light-shielded conditions.

[0044] The present invention also provides a piezoelectric hydrogel, which is prepared by spraying and photocuring the piezoelectric hydrogel composition described in the above technical solution.

[0045] The present invention does not make specific limitations on the spraying parameters, as long as the piezoelectric hydrogel composition can be sprayed out in the form of a spray.

[0046] In the present invention, the wavelength of the light-curing light source is 245 nm to 700 nm, specifically preferably 395 nm; the power is 3 W to 50 W, specifically preferably 3 W, 5 W, 10 W, 15 W, 20 W, 25 W, 30 W, 35 W, 40 W, 45 W or 50 W. In the present invention, the light-curing time is preferably 1 to 10 s, specifically preferably 1 s, 2 s, 3 s, 4 s, 5 s, 6 s, 7 s, 8 s, 9 s or 10 s

[0047] The present invention also provides an application of the piezoelectric hydrogel composition or the piezoelectric hydrogel described in the above technical solution in the preparation of biomaterials.

[0048] In the present invention, the biomaterial preferably includes a dental brace or a biosensor.

[0049] The present invention does not limit the application method, and those skilled in the art can set it according to actual needs.

[0050] The following combines examples to elaborate in detail on the piezoelectric hydrogel composition, piezoelectric hydrogel and their applications provided by the present invention, but they cannot be understood as limiting the protection scope of the present invention.

[0051] Example 1

[0052] Preparation of piezoelectric hydrogel composition:

[0053] Dissolve 0.6 g of TMAO polymerization monomer (172 g / mol, 3.5 mmol) in 0.6 g of ultrapure water. Subsequently, weigh 9.9 mg of N,N-methylenebisacrylamide and 40 μL of photoinitiator lithium phenyl(2,4,6-trimethylbenzoyl)phosphate aqueous solution (concentration 0.05 g / mL) and dissolve them in the above solution and mix evenly to obtain a piezoelectric hydrogel composition.

[0054] Load the above piezoelectric hydrogel composition into a high-pressure spray gun, adjust the pressure of the spray gun and the volume of the liquid output to form a misty state. After spraying on the surface of the polyurethane, start timing. Irradiate with an ultraviolet lamp with a power of 5 W and a wavelength of 395 nm for 5 s to form a stable piezoelectric hydrogel.

[0055] Among them, the preparation method of the TMAO polymerization monomer includes the following steps:

[0056] Dissolve diethylenetriaminepentaacetic acid in ultrapure water to obtain an aqueous solution of diethylenetriaminepentaacetic acid with a concentration of 26 mg / mL; then add hydrogen peroxide with a mass concentration of 30-50% to the aqueous solution of diethylenetriaminepentaacetic acid. After the addition of hydrogen peroxide is complete, heat the system to 60 °C in an oxygen atmosphere. Add an aqueous solution of dimethylaminopropylacrylamide with a concentration of 1.4 mg / mL to the above system within 30 min, and continue to react at 60 °C for 6 h; cool the reaction feed liquid to room temperature, extract the reaction feed liquid with dichloromethane to obtain an organic phase; wash the organic phase with an aqueous sodium chloride solution, and then remove the organic solvent by rotary evaporation to obtain the TMAO polymerization monomer; wherein, the molar amount of hydrogen peroxide in the hydrogen peroxide is 0.45 times the molar amount of dimethylaminopropylacrylamide, and the molar ratio of diethylenetriaminepentaacetic acid to dimethylaminopropylacrylamide is 1:20.

[0057] Example 2

[0058] Dissolve 0.8 g of the TMAO polymerization monomer (prepared in the same way as in Example 1) in 0.6 g of ultrapure water. Subsequently, weigh 9.9 mg of N,N'-methylenebisacrylamide and 40 μL of an aqueous solution of the photoinitiator lithium phenyl(2,4,6-trimethylbenzoyl)phosphate (concentration: 0.05 g / mL) and dissolve them in the above solution and mix evenly to obtain the piezoelectric hydrogel composition.

[0059] Load the above piezoelectric hydrogel composition into a high-pressure spray gun, adjust the pressure of the spray gun and the volume of the liquid output to form a misty shape, start timing after spraying on the polyurethane surface, and irradiate with an ultraviolet lamp with a power of 5 W and a wavelength of 395 nm for 5 s to form a stable piezoelectric hydrogel.

[0060] Example 3

[0061] Dissolve 0.6 g of the TMAO polymerization monomer (prepared in the same way as in Example 1) in 0.6 g of ultrapure water. Subsequently, weigh 15 mg of N,N'-methylenebisacrylamide and 40 μL of an aqueous solution of the photoinitiator lithium phenyl(2,4,6-trimethylbenzoyl)phosphate (concentration: 0.05 g / mL) and dissolve them in the above solution and mix evenly to obtain the piezoelectric hydrogel composition.

[0062] Load the above piezoelectric hydrogel composition into a high-pressure spray gun, adjust the pressure of the spray gun and the volume of the liquid output to form a misty shape, start timing after spraying on the polyurethane surface, and irradiate with an ultraviolet lamp with a power of 5 W and a wavelength of 395 nm for 5 s to form a stable piezoelectric hydrogel.

[0063] Performance test

[0064] (1) Scanning electron microscope analysis

[0065] The morphology of the piezoelectric hydrogel obtained in Example 2 was analyzed using a scanning electron microscope, and the results are as Figure 1 shown, Figure 1 Figure Figure 1 is a scanning electron microscope photograph of the piezoelectric hydrogel obtained in Example 2. As Figure 1 shown, many microscopic pores were formed in the hydrogel network structure.

[0066] (2) Elastic modulus

[0067] The mechanical properties of the piezoelectric hydrogel obtained in Example 2 were measured using a rheometer. The piezoelectric hydrogel obtained in Example 2 (a cylindrical specimen with a diameter of 25 mm and a height of 1 mm) was compressed at 1 mm / min, and the elastic modulus values (storage modulus and loss modulus) of the piezoelectric hydrogel were recorded. The results are as Figure 2 shown, Figure 2 Figure Figure 2 is a graph of the storage modulus and loss modulus of the piezoelectric hydrogel obtained in Example 2. It can be seen from Figure 2 Figure Figure 2 that the storage modulus of the hydrogel is 19.31 kPa and the loss modulus is 1.74 kPa, indicating excellent elastic properties.

[0068] (3) Adhesion

[0069] The piezoelectric hydrogel composition obtained in Example 2 was evenly sprayed on a polyurethane substrate, with an area of 1.5 cm in length and 1 cm in width, such that this area fully covered the piezoelectric hydrogel composition during specimen lamination. Photocuring was performed under an ultraviolet lamp with a power of 5 W and a wavelength of 395 nm for 5 s. After the piezoelectric hydrogel composition obtained in Example 2 was cured, the interfacial adhesion between the formed piezoelectric hydrogel and polyurethane was tested. The results were as follows: The piezoelectric hydrogel obtained in Example 2 had good adhesion, and the lap shear strength of the polyurethane interface was 113 MPa, and it was applicable to the adhesion of different transparent substrate materials.

[0070] (4) Testing of piezoelectric properties

[0071] To determine the piezoelectric characteristics of the piezoelectric hydrogel, the piezoelectric hydrogel obtained in Example 2 was placed between two flexible copper electrode films at both ends to form a piezoelectric generator. The piezoelectric generator was subjected to periodic compression generated by a self-controlled linear motor. Through a piezoelectric test system, the corresponding current output of the piezoelectric generator under different pressure stimuli was recorded. The results are as Figure 3 shown, Figure 3 Figure Figure 3 is a graph of the open-circuit voltage generated by the piezoelectric hydrogel obtained in Example 2 under a pressure of 10 N. It can be seen from Figure 3 Figure Figure 3 that the output open-circuit voltage is approximately 0.6 V. These results confirm that the piezoelectric hydrogel can effectively generate piezoelectric-stimulated electrical signals under various external forces and can convert mechanical energy into electrical energy under continuous pressure, with good stability.

[0072] (5) Anti-protein adsorption

[0073] The piezoelectric hydrogel composition of Example 2 was evenly sprayed on a polyurethane substrate and cured under an ultraviolet lamp with a power of 5 W and a wavelength of 395 nm for 5 s. The polyurethane coated with the piezoelectric hydrogel was immersed in a 1 mg / mL FITC-BSA solution. After adsorption at 37 °C for 2 hours, it was washed three times with PBS, and the adhesion of proteins on the hydrogel surface was observed with a fluorescence microscope. The results are as Figure 4 shown, Figure 4 Figure (a) is the microscopic image of the piezoelectric hydrogel obtained in Example 2 on the polyurethane coating, and the fluorescence images of anti-protein adsorption before (b) and after (c) spraying the hydrogel on the polyurethane surface. As Figure 4 shown, the piezoelectric hydrogel of the present invention has significantly enhanced anti-protein adhesion performance, demonstrating its potential in biomedical applications. The incorporation of the piezoelectric hydrogel can generate local electrical signals, thereby regulating and enhancing the inflammatory response of macrophages, providing a new method for controlling immune behavior in a therapeutic environment.

[0074] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A piezoelectric hydrogel composition, characterized in that: The invention comprises a polymerizable monomer, a crosslinking agent, a photoinitiator and water. The polymerizable monomer is trimethylamine N-oxide, and the crosslinking agent is a photosensitive crosslinking agent.

2. The piezoelectric hydrogel composition according to claim 1, characterized in that: The preparation method of trimethylamine N-oxide comprises the following steps: Dissolving diethylenetriaminepentaacetic acid in water to obtain a diethylenetriaminepentaacetic acid solution; Hydrogen peroxide and dimethylaminopropyl acrylamide are sequentially added to the diethylenetriaminepentaacetic acid solution to react and obtain the trimethylamine N-oxide.

3. The piezoelectric hydrogel composition according to claim 2, characterized in that: The concentration of the diethylenetriaminepentaacetic acid solution is 10-30 mg / mL; The mass concentration of the hydrogen peroxide is 30-50%; The molar amount of hydrogen peroxide in the hydrogen peroxide is 0.2 to 2 times the molar amount of the dimethylaminopropyl acrylamide; The molar ratio of the diethylenetriaminepentaacetic acid to dimethylaminopropylacrylamide is 1:10 to 1:

30.

4. The piezoelectric hydrogel composition according to claim 2, characterized in that: The method of sequentially adding hydrogen peroxide and dimethylaminopropyl acrylamide to the diethylenetriaminepentaacetic acid solution comprises: adding hydrogen peroxide to the diethylenetriaminepentaacetic acid solution, heating the solution to the reaction temperature under an oxygen atmosphere after the hydrogen peroxide is added, and adding the dimethylaminopropyl acrylamide; the dimethylaminopropyl acrylamide is used in the form of a dimethylaminopropyl acrylamide aqueous solution, and the dimethylaminopropyl acrylamide aqueous solution is added within 30 minutes.

5. The piezoelectric hydrogel composition according to claim 2 or 4, characterized in that: The reaction temperature is 50-70° C. and the reaction time is 5-12 hours.

6. The piezoelectric hydrogel composition according to claim 1, characterized in that: The photosensitive crosslinking agent is an acrylamide compound, and the acrylamide compound includes one or more of N,N-methylenebisacrylamide, N,N-dimethylacrylamide, N-isopropylacrylamide and methacrylamide.

7. The piezoelectric hydrogel composition according to claim 1, characterized in that: The photoinitiator is phenyl (2,4,6-trimethylbenzoyl) lithium phosphate or 2-hydroxy-2-methyl-1-phenyl-1-propanone.

8. The piezoelectric hydrogel composition according to claim 1, 6 or 7, characterized in that: The molar ratio of the water, the polymerizable monomer, the crosslinking agent and the photoinitiator is 4000-5000:500-1000:5-20:

1.

9. A piezoelectric hydrogel, characterized in that: The piezoelectric hydrogel composition according to any one of claims 1 to 8 is prepared by spraying and photocuring, wherein the wavelength of the light source for photocuring is 245nm to 700nm and the power is 3W to 50W.

10. Use of the piezoelectric hydrogel composition according to any one of claims 1 to 8 or the piezoelectric hydrogel according to claim 9 in preparing biomaterials.

Images