Preparation device and use method of traditional Chinese medicine preparation nanosphere solution

Abstract

The invention provides a preparation device of a traditional Chinese medicine preparation nanosphere solution and a use method, the preparation device comprises a main shell assembly, a liquid outlet component, a turnover centrifugal assembly, a special-shaped guide surface, a centrifugal sealing assembly and an auxiliary clamping component, and a side arm can drive a centrifugal tube to rotate and adjust; the centrifugal tube is rotated to a vertical high-speed centrifugal rotation position and an inclined position communicated with the liquid outlet guide groove; when the side arm drives the centrifugal tube to rotate towards the centrifugal sealing assembly, the outer surface of the special-shaped guide surface connected to the top end of the side arm can be in sliding tangent fit with the sealing side pushing column in an elastic opening state, so that after the centrifugal tube rotates to a vertical position, the conical inserting column can be just smoothly pressed and buckled at the opening position of the top end of the centrifugal tube; the driven clamping column with outward elasticity is right opposite to a clamping hole in the lower end of the sealing side pushing column; when the centrifugal tube centrifugally rotates at a high speed, the sliding sleeve can be pushed to move to be matched with the driven clamping column, so that the outer end of the driven clamping column is clamped into the clamping hole, and the safety and the stability are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of nano-preparation devices for traditional Chinese medicine preparations, and particularly relates to a preparation device and a usage method for a nano-sphere solution of traditional Chinese medicine preparations. Background Art

[0002] The combination of nanotechnology and traditional Chinese medicine preparations is an important research direction in the modernization of traditional Chinese medicine in recent years. It can not only improve the bioavailability of poorly soluble components, enhance the drug delivery efficiency, but also achieve the sustained release of traditional Chinese medicine preparations, prolong the drug action time, and reduce the frequency of taking medicine.

[0003] In the laboratory, the preparation process of the nano-sphere solution of traditional Chinese medicine preparations is as follows: 1. Material preparation: Weigh two different specifications of PLGA and dissolve it in dichloromethane to prepare an organic phase; dissolve the traditional Chinese medicine preparation in distilled water to prepare an aqueous phase; pre-treat the dialysis bag and soak it for later use. 2. Emulsification-solvent evaporation: Add the PLGA organic phase to the aqueous phase of the traditional Chinese medicine preparation rotating at high speed to form a primary emulsion; transfer the primary emulsion to distilled water rotating at high speed and stir for 2 hours to evaporate dichloromethane to form a nano-sphere solution. 3. Purification: Dialyze the nano-sphere solution with a dialysis bag to remove free drugs or solvent residues, and store it at 4°C for later use.

[0004] Currently, in the process of preparing the nano-sphere solution, a standard centrifuge is required. While centrifuging the aqueous phase of the traditional Chinese medicine preparation with a test tube rotating at high speed, the PLGA organic phase is added to the test tube or the primary emulsion is added to the test tube containing distilled water rotating at high speed. However, the above operations have the disadvantages of cumbersome operation, low efficiency, and poor safety due to the lack of special equipment. Summary of the Invention

[0005] The purpose of the present invention is to provide a preparation device for a nano-sphere solution of traditional Chinese medicine preparations, in which the centrifuge tube can rotate to a vertical high-speed centrifugation rotation position and an inclined position communicated with the liquid outlet guide groove; and when the side arm drives the centrifuge tube to rotate towards the centrifugation sealing component, the outer surface of the special-shaped guide surface can form a sliding tangential fit with the elastically expanded sealing side push column, so that after the centrifuge tube rotates to the vertical centrifugation position, the conical insertion column can just press and buckle on the top of the centrifuge tube, and the passively clamped column elastically outward is aligned with the clamping hole at the lower end of the sealing side push column; when the centrifuge tube rotates at high speed, the sliding sleeve is synchronously pushed to move and cooperate with the passively clamped column, and the outer end of the passively clamped column is clamped into the clamping hole, which is safe and reliable. The purpose of the present invention is achieved through such a technical solution, a preparation device for a nano-sphere solution of traditional Chinese medicine preparations, including a main shell component, a liquid outlet component, a flipable centrifugation component, a special-shaped guide surface, a centrifugation sealing component, and an auxiliary clamping component; The liquid outlet component includes a side cover, the flip - type centrifugal component includes side arms, the centrifugal sealing component includes conical insertion posts, and the auxiliary clamping component includes sliding sleeves; On one side of the main body of the main housing assembly, there are two symmetrically fixed liquid outlet guide grooves that slope downward and outward. The side cover is rotatably connected to the outside of the main housing assembly, and passive convex posts are fixedly connected to both sides of the upper inner end of the side cover; The side arms are rotatably connected in pairs to the other side of the inner bottom end of the main housing assembly. The special - shaped guide surface is fixedly connected to the top of the side arms. Centrifugal tubes are rotatably arranged in pairs between the side arms. An inner connecting plate is elastically slid inwardly at the inner top end of the main housing assembly. Conical insertion posts are rotatably connected in pairs in the inner connecting plate. Sealing side - pushing posts are horizontally fixed at both outer ends of the inner connecting plate. There are card holes below the outer side of each group of sealing side - pushing posts. Conical sliding seats are fixedly arranged on the outside of the centrifugal tubes. The sliding sleeves are slidably connected to the outside of the centrifugal tubes and the outside of the conical sliding seats. Passive clamping posts are elastically slid inwardly at the upper end of the main body of each group of side arms; A liquid adding component is also installed at the top of the main body of the main housing assembly for quantitatively adding different types of solutions into the centrifugal tubes; Two liquid adding tubes are elastically slid inwardly in pairs at the top of the main body of the main housing assembly. A liquid adding inner connecting plate is fixedly connected between the outer surfaces of the lower ends of the liquid adding tubes. Liquid adding side - pushing posts are also horizontally fixedly connected to both outer ends of the liquid adding inner connecting plate.

[0006] The usage process of the technical solution of the present invention is as follows: When the side arms drive the centrifugal tubes and the special - shaped guide surfaces to rotate towards the liquid adding component, the cooperation formed by the outside of the special - shaped guide surface and the elastically downward liquid adding side - pushing posts can make the liquid adding side - pushing posts just snap into the groove in the middle of the outside of the special - shaped guide surface after the centrifugal tubes rotate to a certain inclined position. Synchronously, the bottom end of the liquid adding tube extends into the centrifugal tube, and solutions can be safely added into the centrifugal tube through the liquid adding tube; Two different centrifugal tubes are used to add PLGA solutions with different ratio specifications and a certain traditional Chinese medicine solution. After adding a certain volume of distilled water and high - speed stirring for 2 hours until the solutions are evenly dispersed and the dichloromethane is completely volatilized, two different traditional Chinese medicine preparation nanosphere solutions with a certain volume and concentration can be obtained; And during the process of the side arms rotating to the vertical state of the centrifugal tubes, it can drive the outside of the special - shaped guide surface to form a sliding tangent fit with the sealing side - pushing posts. Through the special - shaped curved surface on the outside of the special - shaped guide surface, it can push the elastically inward inner connecting plate to form a moving action, so as to drive the centrifugal tubes to rotate towards the vertical state in cooperation with the side arms. The conical insertion posts in the free - rotation state can snap into the top opening of the centrifugal tubes. At this time, the outside of the sealing side - pushing posts elastically abuts against the groove in the middle of the outside of the special - shaped guide surface, and the position of the card hole is just horizontally opposite to the passive clamping posts; Subsequently, the centrifuge tube rotates at high speed, and the centrifugal force generated will overcome the gravity of the sleeve when it reaches a certain level, pushing the sleeve to move from the large cone surface to the small cone surface along the outside of the conical slide seat, that is, when the centrifuge tube is vertical and rotates at high speed, the sleeve can move from bottom to top along the conical slide seat; Since the outer surface of the sliding sleeve is also a conical surface, when the sliding sleeve moves upward, it will drive the outer surface of the sliding sleeve to form a sliding tangent fit with the inner end spherical surface of the passive clamping column, pushing the passive clamping column elastically inward to move outward, and the passive clamping column will be inserted into the clamping hole after moving outward; so that when the centrifuge tube rotates at a high speed, the conical plug column can be stably pressed and buckled at the top opening of the centrifuge tube through the transverse plugging effect formed by the passive clamping column and the clamping hole, and a vent hole is opened in the middle of the conical plug column, which can improve the stability of the high-speed rotation of the centrifuge tube on the one hand, and can also discharge dichloromethane on the other hand; After the centrifugal tube in the vertical state is centrifuged and rotated, the sliding sleeve will move downward under the action of its own gravity and separate from the inner end spherical surface of the passive clamping column. Under the action of the passive clamping column's own elastic force, the passive clamping column will return to the inside and be disconnected from the clamping hole. The side arm drives the centrifuge tube to rotate in the direction of the liquid outlet guide groove, and the outer side of the special-shaped guide surface forms a sliding tangent fit with the outer side of the sealing side push column, pushing the tapered plug column to disengage from the top opening of the centrifuge tube until the outer side of the centrifuge tube contacts the inner groove surface of the liquid outlet guide groove. Synchronously, the side cover in a naturally elastic closed state is opened through the sliding tangent fit formed by the outer side of the special-shaped guide surface and the passive convex column, and the two different traditional Chinese medicine nanosphere solutions that have been centrifugally stirred in the centrifuge tube flow out from the liquid outlet guide groove.

[0007] Another object of the present invention is to provide a method for using a device for preparing a nanosphere solution of a traditional Chinese medicine preparation, comprising the following steps: S1. The operator controls the movement of the telescopic rod of the servo electric cylinder through the main control screen. The telescopic rod of the servo electric cylinder can drive the rotation of the side arm and the centrifuge tube through the transmission mechanism, and cooperate with the use of the special-shaped guide surface to rotate the centrifuge tube to a position connected with the bottom opening of the liquid adding tube. When the centrifuge tube rotates toward the liquid adding component, the outer surface of the special-shaped guide surface cooperates with the elastic downward liquid adding side push column. After the centrifuge tube rotates to a certain inclined position, the liquid adding side push column just elastically snaps into the groove in the middle of the outer surface of the special-shaped guide surface, and the bottom end of the liquid adding tube extends into the centrifuge tube. PLGA solutions of different ratios and specifications, a certain Chinese medicinal material solution and distilled water can be quantitatively added to the centrifuge tube through the liquid adding bucket and the liquid adding tube; S2. After the solution in the centrifuge tube is added, the operator controls the movement of the telescopic rod of the servo electric cylinder again through the main control panel, causing the side arm and the centrifuge tube to rotate and move towards the centrifugal sealing assembly until the centrifuge tube rotates to a vertical state. The outer surface of the special-shaped guide surface forms an elastic sliding connection with the liquid addition side push column, pushing the liquid addition tube out of the top opening of the centrifuge tube. The side arm drives the centrifuge tube to continue rotating towards the vertical state, which will cause the outer surface of the special-shaped guide surface to form a sliding tangential fit with the sealing side push column, pushing the inward elastic inner connecting plate to form a moving action, so as to drive the centrifuge tube to rotate towards the vertical state in cooperation with the side arm. With the use of the special-shaped guide surface, the conical insertion column in the free rotation state is inserted into the top opening of the centrifuge tube. At this time, the outer surface of the sealing side push column elastically abuts against the groove in the middle of the outer surface of the special-shaped guide surface, and the position of the card hole is horizontally aligned with the passive card column; S3. The operator controls the rotation drive mechanism connected to the centrifuge tube through the main control panel. The centrifuge tube rotates at a high speed, and the solution and distilled water in the centrifuge tube can be mixed. When the centrifugal force generated by the rotation of the centrifuge tube reaches a certain level, it will overcome the gravity of the sliding sleeve itself and push the sliding sleeve to move along the outer surface of the conical sliding seat from the large cone surface to the small cone surface. That is, when the centrifuge tube is vertical and rotating at a high speed, the sliding sleeve can move upward along the conical sliding seat. When the sliding sleeve moves upward, it will drive the outer surface of the sliding sleeve to form a sliding tangential fit with the inner end spherical surface of the passive card column, pushing the inward elastic passive card column to move outward and insert into the card hole; so that in the state where the centrifuge tube rotates at a high speed, the conical insertion column will be stably buckled at the top opening of the centrifuge tube through the transverse insertion action formed by the passive card column and the card hole. There are ventilation holes in the middle of the conical insertion column, which can discharge dichloromethane; S4. Discharge of the prepared solution. The operator controls the rotation drive mechanism connected to the centrifuge tube through the main control panel. After the centrifuge tube completes centrifugal rotation, it stops rotating. Under the action of the gravity of the sliding sleeve itself, it will drive the sliding sleeve to move downward and disengage from the inner end spherical surface of the passive card column. Under the action of the elastic force of the passive card column itself, the passive card column will return to the inner side and disengage from the card hole. The operator controls the movement of the telescopic rod of the servo electric cylinder through the main control panel, so that the servo electric cylinder drives the rotation of the side arm and the centrifuge tube through the transmission mechanism. With the use of the special-shaped guide surface, the centrifuge tube rotates towards the liquid discharge guide groove. The outer surface of the special-shaped guide surface forms a sliding tangential fit with the outer surface of the sealing side push column, pushing the conical insertion column to disengage from the top opening of the centrifuge tube. During this process, the outer surface of the special-shaped guide surface will also form a sliding tangential fit with the liquid addition side push column, and will not interfere with the rotation and movement of the centrifuge tube towards the liquid discharge guide groove. And through the sliding tangential fit formed by the outer surface of the special-shaped guide surface and the passive convex column, the side cover in the natural elastic closed state is opened until the outer surface of the centrifuge tube contacts the inner groove surface of the liquid discharge guide groove. The two different traditional Chinese medicine preparation nanosphere solutions that have been centrifugally stirred in the centrifuge tube are discharged from the liquid discharge guide groove for subsequent processes.

[0008] By adopting the above technical solutions, the present invention can achieve the following beneficial effects: (1) The purpose of setting the centrifugal tubes and the liquid outlet guide grooves in paired distribution in the present invention is to simultaneously perform high-speed centrifugal stirring operations on two groups of PLGA solutions and traditional Chinese medicine solutions with different ratio specifications. Since different ratios of PLGA will affect the degradation rate, drug release behavior, and physicochemical properties of the nanoparticles, by comparing the nanoparticle solutions prepared with two PLGA specifications, it can be evaluated which ratio is more suitable for loading traditional Chinese medicine preparations, thereby optimizing the performance of the nanocarrier; (2) The purpose of the side arm driving the centrifugal tube to rotate in the present invention is to not only form a high-speed centrifugal stirring operation in the vertical state of the centrifugal tube but also enable the centrifugal tube to rotate to a position where it contacts the inner groove surface of the liquid outlet guide groove, forming the discharge operation of the prepared traditional Chinese medicine preparation nanoparticle solution; (3) Moreover, the present invention not only has a special-shaped guide surface and a centrifugal sealing component. During the process of driving the centrifugal tube to rotate to the vertical state by the side arm, the cooperation formed by the outer surface of the special-shaped guide surface and the sealing side push column that elastically moves inward can make the conical insertion column just be able to be inserted into the top opening of the centrifugal tube after the centrifugal tube rotates to the vertical state, so that both the upper and lower ends of the centrifugal tube form a rotation reference, improving the centrifugal rotation accuracy of the centrifugal tube; it also has an auxiliary clamping component, which can make the centrifugal force generated when the centrifugal tube rotates at high speed push the sliding sleeve upward, and push the passively inward elastic clamping column into the clamping hole, improving the stability of the clamping connection between the conical insertion column and the centrifugal tube; at the same time, another purpose of sliding the sliding sleeve on the outer surface of the centrifugal tube is that the sliding sleeve can increase the counterweight, improving the running stability of the centrifugal tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art.

[0010] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the main housing assembly of the present invention; Figure 3 It is a schematic diagram of the structure of the liquid outlet component from the first perspective of the present invention; Figure 4 It is a schematic diagram of the structure of the liquid outlet component from the second perspective of the present invention; Figure 5 It is a schematic diagram of the structure of the side rotating arm part of the present invention; Figure 6 It is a schematic diagram of the structure of the flip-type centrifugal component of the present invention; Figure 7 It is a schematic diagram of the structure of the special-shaped guide surface and the side arm part of the present invention; Figure 8 Structural schematic diagram of the liquid adding component of the present invention; Figure 9 Structural schematic diagram of the centrifugal sealing component of the present invention; Figure 10 Structural schematic diagram of the connection between the card hole and the sealing side push column of the present invention; Figure 11 Structural schematic diagram of the auxiliary clamping component of the present invention; Figure 12 Structural schematic diagram of the cooperation between the sliding sleeve and the passive clamping column of the present invention; Figure 13 Structural schematic diagram of the sliding sleeve part of the present invention; Figure 14 Structural schematic diagram of the cooperation between the special-shaped guide surface and the passive convex column of the present invention; Figure 15 Structural schematic diagram of the cooperation between the special-shaped guide surface and the liquid adding side push column of the present invention; Figure 16 Structural schematic diagram of the cooperation between the special-shaped guide surface and the sealing side push column of the present invention.

[0011] Reference numerals: 1, main housing assembly; 2, liquid outlet member; 3, reversible centrifugal assembly; 4, special-shaped guide surface; 5, liquid adding member; 6, centrifugal sealing and fixing assembly; 7, auxiliary clamping member; 101, base; 102, main housing; 103, transparent cover; 104, main control screen; 201, side seat; 202, liquid outlet guide groove; 203, side cover; 204, side rotating arm; 205, side rotating hole; 206, soft sleeve; 207, inner seat; 208, side rotating shaft; 209, passive convex column; 210, elastic piece seat; 211, self-closing elastic piece; 301, vertical seat; 302, flipping rotating shaft; 303, flipping fixing frame; 304, centrifugal rotating seat; 305, centrifugal tube; 306, centrifugal shaft; 307, centrifugal gear; 308, centrifugal motor; 309, centrifugal driving gear; 310, side arm; 311, flipping pinion; 312, flipping driving shaft; 313, flipping driving large gear; 314, fixing rod; 315, electric cylinder fixing rotating seat; 316, electric cylinder moving rotating seat; 317, servo electric cylinder; 401, S-shaped guide surface; 402, concave guide surface; 501, liquid adding sliding sleeve; 502, liquid adding pipe; 503, liquid adding hopper; 504, top cover; 505, liquid adding inner connecting plate; 506, liquid adding top spring; 507, liquid adding side pushing column; 601, sliding seat; 602, sliding column; 603, outer connecting plate; 604, inner connecting plate; 605, sealing and fixing top spring; 606, passive rotating seat; 607, conical inserting column; 608, sealing and fixing pressing sleeve; 609, sealing and fixing side pushing column; 610, air release micro-hole; 701, clamping seat; 702, clamping hole; 703, conical sliding seat; 704, sliding sleeve; 705, elastic alignment sliding seat; 706, side sliding seat; 707, passive clamping column; 708, compression spring clamping sleeve; 709, compression spring; 710, push spring clamping hole; 711, pushing spring; 712, end sleeve; 713, side sliding groove; 714, middle sliding hole; 715, compression spring placing hole. Detailed implementation manners

[0012] To make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0013] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0014] As Figures 1 - 16 shown, a preparation device for a traditional Chinese medicine preparation nanosphere solution. On one side of the main body of the main housing assembly 1, there are fixedly provided paired liquid outlet guide grooves 202 that slope downward and outward. The side cover 203 is rotatably connected to the outside of the main housing assembly 1 for forming a closed protection for the liquid outlet guide grooves 202 when not in use and an opening when in use. On both sides of the inner upper end of the side cover 203, there are fixedly connected passive convex columns 209, and when there is no external force to push the side cover 203, the side cover 203 is in a natural closed state; The side arms 310 are rotatably connected in pairs to the other side of the inner bottom end of the main housing assembly 1. The special-shaped guide surface 4 is fixedly connected to the top ends of the side arms 310. Between the side arms 310, there are rotatably provided paired centrifuge tubes 305. The inner top end of the main housing assembly 1 is slidably connected with an inner connecting plate 604 that elastically moves inward. The tapered plug posts 607 are rotatably connected in pairs in the inner connecting plate 604, and the center distance of the tapered plug posts 607 is equal to the center distance of the centrifuge tubes 305. On both outer ends of the inner connecting plate 604, there are horizontally fixed sealing side push posts 609. Below the outer side of each group of sealing side push posts 609, there are card holes 702. On the outer surface of the centrifuge tube 305, there are arranged and fixedly connected tapered sliding seats 703. The sliding sleeve 704 is slidably connected to the outer surface of the centrifuge tube 305 and the outer surface of the tapered sliding seat 703. On the upper end of the main body of each group of side arms 310, there is slidably connected a passive clamping post 707 that elastically moves inward; and after the centrifuge tube 305 rotates to a certain rotational speed, the generated centrifugal force can push the sliding sleeve 704 to move along the outer surface of the tapered sliding seat 703 from the large conical surface to the small conical surface; The working principle is as follows: In two different centrifuge tubes 305, different proportion specifications of PLGA solutions and a certain traditional Chinese medicine solution are added. After adding a certain volume of distilled water and high-speed stirring for 2 hours until the solution is evenly dispersed, the dichloromethane (dichloromethane is a raw material for preparing the PLGA solution in the previous work) is completely volatilized, and two different traditional Chinese medicine preparation nanosphere solutions with a certain volume and a certain concentration can be obtained; During the working process, the set rotational speed of the centrifuge tube 305 is 1500 r / min; The purpose of setting the side arms 310 to be rotatable automatically is that the rotation of the side arms 310 can drive the centrifuge tubes 305 to form a rotational movement, so that the centrifuge tubes 305 can not only perform high-speed centrifugation work in a vertical state, but also pour the nanosphere solution after the centrifugal stirring is completed; During the process of the side arm 310 rotating to the vertical state of the centrifuge tube 305, it can drive the outer surface of the special-shaped guide surface 4 to form a sliding tangent fit with the sealing and pushing column 609. Through the special-shaped curved surface on the outer surface of the special-shaped guide surface 4, it can push the inward elastic inner connecting plate 604 to form a moving action, so that the side arm 310 drives the centrifuge tube 305 to rotate towards the vertical state. The conical insertion column 607 in the free rotation state can be inserted into the top opening of the centrifuge tube 305. At this time, the outer surface of the sealing and pushing column 609 elastically abuts against the groove in the middle of the outer surface of the special-shaped guide surface 4, and the position of the card hole 702 is just horizontally opposite to the passive card column 707; Subsequently, the centrifuge tube 305 rotates at a high speed. When the centrifugal force generated reaches a certain level, it will overcome the gravity of the sliding sleeve 704 itself and push the sliding sleeve 704 to move along the outer surface of the conical sliding seat 703 from the large conical surface to the small conical surface. That is, when the centrifuge tube 305 is vertical and rotating at a high speed, the sliding sleeve 704 can move upward along the conical sliding seat 703; Since the outer surface of the sliding sleeve 704 is also a conical surface, when the sliding sleeve 704 moves upward, it will drive the outer surface of the sliding sleeve 704 to form a sliding tangent fit with the inner spherical surface of the passive card column 707, and push the inward elastic passive card column 707 to move outward. After the passive card column 707 moves outward, it will be inserted into the card hole 702; so that when the centrifuge tube 305 rotates at a high speed, the conical insertion column 607 will be stably buckled at the top opening of the centrifuge tube 305 through the transverse plugging action formed by the passive card column 707 and the card hole 702. There are ventilation holes in the middle of the conical insertion column 607, which can improve the stability of the high-speed rotation of the centrifuge tube 305 on the one hand, and can also discharge dichloromethane on the other hand; After the centrifugal rotation of the centrifuge tube 305 in the vertical state is completed, under the action of the gravity of the sliding sleeve 704 itself, the sliding sleeve 704 will move downward and disengage from the inner spherical surface of the passive card column 707. Under the action of the elastic force of the passive card column 707 itself, the passive card column 707 will return to the inside and disengage from the card hole 702; The side arm 310 drives the centrifuge tube 305 to rotate towards the direction of the liquid outlet guide groove 202. The outer surface of the special-shaped guide surface 4 forms a sliding tangent fit with the outer surface of the sealing and pushing column 609, and pushes the conical insertion column 607 to disengage from the top opening of the centrifuge tube 305 until the outer surface of the centrifuge tube 305 contacts the inner groove surface of the liquid outlet guide groove 202. At the same time, the sliding tangent fit formed by the outer surface of the special-shaped guide surface 4 and the passive convex column 209 opens the side cover 203 in the natural elastic closed state. The two different traditional Chinese medicine preparation nanosphere solutions that have been centrifugally stirred in the centrifuge tube 305 flow out through the liquid outlet guide groove 202 and are transferred to the next process.

[0015] The specific structures of the main housing assembly 1 and the liquid outlet component 2 are as Figure 2 、 Figure 3 、 Figure 4 andFigure 5 As shown, the top end of the base 101 is fixedly connected to the bottom opening of the main housing 102. A transparent cover 103 is fixedly installed at the top end of the side of the main housing 102, which can be used to observe the working conditions inside the transparent cover 103; The main control screen 104 is installed and fixed at the lower end of the main surface of the main housing 102 and is connected to the electric control components of the device for automatic control of the device; The side seat 201 is fixed to the lower end of the outer side of the main housing 102. The inner bottom surface of the liquid outlet guide groove 202 is fixedly connected to the top end of the base 101, and the outer end extends from the main body of the main housing 102 into the side seat 201; On both upper ends of the side surfaces of the side cover 203, side rotating arms 204 are fixedly connected. Side rotating holes 205 are symmetrically opened in the main body of the side of the main housing 102. A soft sleeve 206 is fixedly connected in each group of side rotating holes 205. The main body of the side rotating arm 204 is connected to the soft sleeve 206. Inner seats 207 are fixedly connected in pairs to the side surfaces of the inner cavity of the main housing 102. A side rotating shaft 208 is horizontally fixed on the side surface where each group of side rotating arms 204 extends into the inner cavity of the main housing 102. The side rotating shafts 208 on the same side are rotatably connected to the inner seats 207; The passive convex column 209 is fixedly connected to the inner end of the side rotating arm 204; The purpose of setting the soft sleeve 206 is to form a closed effect on the side rotating holes 205 through the flexible material structure of the soft sleeve 206 itself without affecting the rotation of the side rotating arms 204; On the side surface of each group of side rotating arms 204, a spring piece card seat 210 is also fixedly connected. One end of the self-closing spring piece 211 is fixedly connected to the side surface of the inner cavity of the main housing 102, and the other end is fixedly connected to the spring piece card seat 210. The self-closing spring piece 211 can form an elastic thrust working for the side rotating arms 204 to rotate with the inner seat 207 as the reference. When there is no external force to push the side rotating arms 204, the side cover 203 is in a position where it is buckled with the side seat 201, forming a protection for the outlet end of the liquid outlet guide groove 202.

[0016] The specific structures of the flip-type centrifugal component 3 and the special-shaped guide surface 4 are as Figure 6 and Figure 7 shown. The top end of the base 101 is fixedly connected with a vertical seat 301. The top end of the vertical seat 301 is horizontally rotatably connected with a flip rotation shaft 302. The bottom end of the flip fixing frame 303 is fixedly connected to the middle part of the flip rotation shaft 302. The bottom end of the side arm 310 is fixedly connected to the outer end of the flip rotation shaft 302; At the top of the main body of the flipping fixture 303, a pair of centrifugal rotating seats 304 are fixedly installed. At the outer bottom end of each group of centrifuge tubes 305, a centrifugal shaft 306 is coaxially fixed. The centrifugal shafts 306 on the same side are rotatably connected to the centrifugal rotating seats 304. A centrifugal gear 307 is inserted and fixed at the bottom end of the centrifugal shaft 306. Inside the flipping fixture 303, a centrifugal motor 308 is fixedly installed. A centrifugal driving gear 309 is inserted and fixed in the rotating shaft of the centrifugal motor 308. The centrifugal gear 307 meshes with the centrifugal driving gear 309, which can drive the two groups of centrifuge tubes 305 to rotate synchronously at high speed; At the bottom end of each side arm 310, a flipping pinion 311 is also coaxially and fixedly connected to the flipping rotating shaft 302. On both outer sides of the vertical seat 301, flipping driving shafts 312 are horizontally and fixedly installed. In each flipping driving shaft 312, a flipping driving large gear 313 is rotatably connected. The flipping pinions 311 on the same side mesh with the flipping driving large gears 313; A fixed rod 314 is fixedly connected to the outer side of the flipping driving large gear 313. On the top end of the base 101, a pair of electric cylinder fixed rotating seats 315 are fixedly installed. At the other end of each fixed rod 314, an electric cylinder moving rotating seat 316 is horizontally and fixedly installed. The main body of the servo electric cylinder 317 is rotatably connected to the electric cylinder fixed rotating seat 315, and the telescopic rod is rotatably connected to the electric cylinder moving rotating seat 316; The purpose of using the servo electric cylinder 317 to drive the flipping fixture 303 and the side arms 310 to rotate through the cooperation transmission formed by the flipping driving large gear 313 and the flipping pinion 311 is that, by using the transmission ratio formed by the flipping driving large gear 313 and the flipping pinion 311, within a relatively small stroke range of the servo electric cylinder 317, the flipping fixture 303 and the side arms 310 can be driven to rotate within a relatively large stroke range; Moreover, the servo electric cylinder 317 is controlled by a servo driver, and the extension and retraction positions of the telescopic rod of the servo electric cylinder 317 can be accurately controlled. Therefore, through the drive of the servo electric cylinder 317, the flipping fixture 303, the side arms 310, and the centrifuge tubes 305 can rotate at high precision at any angle within the set range; The special-shaped curved surface outside the special-shaped guide surface 4 is composed of a concave guide surface 402 and S-shaped guide surfaces 401 symmetrically distributed on both sides. The S-shaped guide surfaces 401 and the concave guide surface 402 form a smooth continuous curved surface.

[0017] The specific structure of the liquid adding component 5 for quantitatively adding different types of solutions and distilled water into the centrifuge tubes 305 is as Figure 8 and Figure 15 shown. The liquid adding sliding sleeves 501 are installed and fixed in pairs on the top cavity wall of the main housing 102. In each liquid adding sliding sleeve 501, a liquid adding tube 502 is slidably inserted. A liquid adding inner connecting plate 505 is fixedly connected between the lower outer surfaces of the liquid adding tubes 502; At the top of each liquid adding pipe 502, a liquid adding hopper 503 is fixedly connected. At the opening at the top of the liquid adding hopper 503, a top cover 504 is covered and connected. The top cover 504 is detachable, which is convenient for adding solution and can also play a protective role; A liquid adding top spring 506 is sleeved and installed in each liquid adding pipe 502. One end of the liquid adding top spring 506 is clamped and fixed to the top of the liquid adding inner connecting plate 505, and the other end is clamped and fixed to the inner top surface of the main housing 102; The supporting elastic force formed by the liquid adding top spring 506 can make the component composed of the liquid adding pipe 502, the liquid adding inner connecting plate 505 and the liquid adding hopper 503 be in the lower limit position when there is no external force pushing; Both outer ends of the liquid adding inner connecting plate 505 are horizontally fixedly connected with liquid adding side push columns 507; When the side arm 310 drives the centrifuge tube 305 and the special-shaped guide surface 4 to rotate towards the liquid adding component 5, the cooperation formed by the outer surface of the special-shaped guide surface 4 and the elastically downward liquid adding side push column 507 can make the liquid adding side push column 507 just be able to snap into the groove in the middle of the outer surface of the special-shaped guide surface 4 when the centrifuge tube 305 rotates to a certain inclined position. Synchronously, the bottom end of the liquid adding pipe 502 extends into the centrifuge tube 305, and a quantitative solution can be safely added into the centrifuge tube 305 through the liquid adding hopper 503 and the liquid adding pipe 502; And when the centrifuge tube 305 needs to be cleaned, cleaning liquid is added into the centrifuge tube 305 through the liquid adding hopper 503 and the liquid adding pipe 502. With the high-speed rotation of the centrifuge tube 305 and the pouring action towards the liquid outlet guide groove 202, the cleaning of the centrifuge tube 305 after use and the discharge of the cleaning liquid can be completed.

[0018] The specific structures of the centrifugal sealing assembly 6 and the auxiliary clamping member 7 are as shown in Figure 9 、 Figure 10 、 Figure 11 、 Figure 12 、 Figure 13 and Figure 16 shown. The sliding seat 601 is installed and fixed at the top of the main body of the main housing 102. At the top of the inner connecting plate 604, sliding columns 602 are fixedly connected in pairs. The outer connecting plate 603 is fixedly connected to the top of the sliding columns 602. The sliding columns 602 are slidably connected with the sliding seat 601; A sealing top spring 605 is sleeved and installed in each sliding column 602. One end of the sealing top spring 605 is clamped and fixed to the inner connecting plate 604, and the other end is clamped and fixed to the inner top of the main housing 102. Under the action of the elastic force of the sealing top spring 605 itself, the inner connecting plate 604 can be elastically downward naturally; In the main body of the inner connecting plate 604, a pair of passive rotating seats 606 are installed and fixed. The top end of the main body of the conical insertion post 607 is rotatably connected to the passive rotating seat 606. A sealing and pressing sleeve 608 is sleeved and fixed on the outside of the main body of each group of conical insertion posts 607. An air release micropore 610 is formed through the middle of the main body of the conical insertion post 607 for discharging gas. The discharged gas can flow through the gaps between the main housing 102 and the base 101 and between the main housing 102 and the transparent cover 103 to the external laboratory environment for purification treatment; The bottom end of the conical insertion post 607 is set to a conical structure, which can facilitate the rotation of the centrifuge tube 305 driven by the side arm 310. The conical insertion post 607 is inserted into the top opening of the centrifuge tube 305, and after the side arm 310 rotates to the position where the sealing side push post 609 is in sliding tangent fit with the concave guide surface 402, the sealing and pressing sleeve 608 is pressed against the top of the centrifuge tube 305; The positions where the conical insertion post 607, the sealing and pressing sleeve 608 contact the centrifuge tube 305 are all flexible structures, which is convenient for the pressing connection with the centrifuge tube 305; The clamping seat 701 is fixedly connected to the outer end of the sealing side push post 609, and a clamping hole 702 is formed at the bottom end of the clamping seat 701; A middle sliding hole 714 is formed in the middle of the sliding sleeve 704. Side sliding grooves 713 are symmetrically formed in the main body of the sliding sleeve 704 with the middle sliding hole 714 as the center. An elastic alignment sliding seat 705 is horizontally slidably connected in each group of side sliding grooves 713. Push spring clamping holes 710 are formed on the outer side surface of the elastic alignment sliding seat 705 and the inner side surface of the side sliding groove 713. The two ends of the pushing spring 711 are respectively fixedly connected to different push spring clamping holes 710. The inner side surface of the same-side elastic alignment sliding seat 705 is slidably connected to the outer surface of the conical sliding seat 703, and the middle sliding hole 714 is slidably connected to the outer surface of the centrifuge tube 305; End sleeves 712 are fixedly connected to the upper and lower ends of the conical sliding seat 703. The end sleeves 712 are sleeved and fixed to the outer surface of the centrifuge tube 305 for safely limiting the moving position of the sliding sleeve 704; When the centrifuge tube 305 is in a stationary state, under the action of its own gravity, the sliding sleeve 704 is in a lower limit position where it does not contact the inner spherical surface of the passive clamping post 707; With the high-speed rotation of the centrifuge tube 305, the centrifugal force formed on the sliding sleeve 704 and the elastic alignment sliding seat 705 can push the sliding sleeve 704 and the elastic alignment sliding seat 705 to move along the outer conical surface of the conical sliding seat 703 from the large conical surface end to the small conical surface; And within the moving stroke range of the sliding sleeve 704 and within the elastic support range of the pushing spring 711, the inner side surface of the elastic alignment sliding seat 705 can always be in sliding contact with the outer surface of the conical sliding seat 703; Moreover, the inward support elastic force formed by the push spring 711 will not affect the sliding fit between the elastic alignment slide 705 and the conical slide 703; Each main body upper end of the group of side arms 310 is horizontally provided with a compression spring placement hole 715. The side slide 706 is fixedly installed at the outer side of the main body upper end of the side arm 310 at a position aligned with the compression spring placement hole 715. The passive clamping post 707 is slidably connected to the inner hole of the side slide 706. The aperture of the compression spring placement hole 715 is larger than the aperture of the inner hole of the side slide 706. A compression spring sleeve 708 is sleeved and fixed on the outer surface of the inner end of the passive clamping post 707. A compression spring 709 is sleeved and installed in each group of passive clamping posts 707. One end of the compression spring 709 is clamped and fixed with the compression spring sleeve 708, and the other end is clamped and fixed with the inner bottom of the compression spring placement hole 715; Under the action of the support elastic force of the compression spring 709, when there is no external force to push the passive clamping post 707, the passive clamping post 707 is in a natural elastic inward state; When the centrifuge tube 305 rotates at a high speed to form a centrifugal force on the sliding sleeve 704 and drives the sliding sleeve 704 to move upward, the outer surface of the sliding sleeve 704 forms a sliding tangent fit with the inner end spherical surface of the passive clamping post 707, so that while the centrifuge tube 305 rotates at a high speed, the outer end of the passive clamping post 707 can be inserted into the clamping hole 702 at the bottom end of the clamping seat 701.

[0019] The present invention also correspondingly provides a usage method of a preparation device for a traditional Chinese medicine preparation nanosphere solution, which is characterized by including the following steps: S1. The operator controls the movement of the telescopic rod of the servo electric cylinder 317 through the main control screen 104. The telescopic rod of the servo electric cylinder 317 can drive the rotation of the side arm 310 and the centrifuge tube 305 through a transmission mechanism. With the use of the special-shaped guide surface 4, the centrifuge tube 305 is rotated to a position where it is connected to the bottom opening of the liquid adding tube 502, and different proportion specifications of PLGA solution, a certain traditional Chinese medicine solution, and distilled water can be quantitatively added into the centrifuge tube 305 through the liquid adding hopper 503 and the liquid adding tube 502; S2. After the solution in the centrifuge tube 305 is added, the operator controls the movement of the telescopic rod of the servo electric cylinder 317 again through the main control screen 104, so that the side arm 310 and the centrifuge tube 305 rotate and move towards the centrifugal sealing component 6 until the centrifuge tube 305 rotates to a vertical state. With the use of the special-shaped guide surface 4, the conical insertion post 607 in the free rotation state is inserted into the top opening of the centrifuge tube 305, and the position of the clamping hole 702 is horizontally aligned with the passive clamping post 707; S3. The operator controls the rotation drive mechanism connected to the centrifuge tube 305 through the main control panel 104. The centrifuge tube 305 rotates at a high speed. In the state where the centrifuge tube 305 is vertical and rotating at a high speed, the sliding sleeve 704 can move upward along the conical sliding seat 703, pushing the passively engaged column 707 with elastic inward movement outward, and inserting it into the engagement hole 702. The solution and distilled water in the centrifuge tube 305 can be mixed stably and safely. The middle of the conical insertion column 607 is provided with a ventilation hole, through which dichloromethane can be discharged; S4. After the preparation is completed, for the discharge of the solution, the operator controls the rotation drive mechanism connected to the centrifuge tube 305 through the main control panel 104. After the centrifuge tube 305 stops rotating after centrifugal rotation, the passively engaged column 707 will return to the inner side and disengage from the engagement hole 702. The operator controls the movement of the telescopic rod of the servo electric cylinder 317 through the main control panel 104, so that the servo electric cylinder 317 drives the rotation of the side arm 310 and the centrifuge tube 305 through the transmission mechanism. With the use of the special-shaped guide surface 4, the centrifuge tube 305 rotates towards the liquid discharge guide groove 202. Through the sliding tangential fit formed by the outer surface of the special-shaped guide surface 4 and the passive convex column 209, the side cover 203 in the natural elastic closed state is opened until the outer surface of the centrifuge tube 305 contacts the inner groove surface of the liquid discharge guide groove 202. The two different traditional Chinese medicine preparation nanosphere solutions that have been centrifugally stirred in the centrifuge tube 305 are discharged outward through the liquid discharge guide groove 202 for subsequent processes.

[0020] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A device for preparing a nanosphere solution of a traditional Chinese medicine preparation, comprising a main shell component (1) and a liquid outlet component (2), characterized in that: It also includes a reversible centrifugal assembly (3), a special-shaped guide surface (4), a centrifugal sealing assembly (6), and an auxiliary clamping component (7); The liquid outlet component (2) comprises a side cover (203), the flippable centrifugal assembly (3) comprises a side arm (310), the centrifugal sealing assembly (6) comprises a conical plug post (607), and the auxiliary fixing component (7) comprises a sliding sleeve (704); A pair of liquid outlet guide grooves (202) are fixedly provided on one side of the main shell assembly (1); a side cover (203) is screwed to the outside of the main shell assembly (1); passive bosses (209) are fixedly provided on both sides of the inner upper end of the side cover (203); side arms (310) are screwed to the other side of the inner bottom end of the main shell assembly (1); a special-shaped guide surface (4) is fixed to the top of the side arm (310); a pair of centrifuge tubes (305) are screwed between the side arms (310); and an inner connecting plate (604) is elastically slidably provided at the inner top of the main shell assembly (1) so as to be elastically slidable inwardly. The conical plug posts (607) are screwed in pairs in the inner connecting plate (604), and the two outer ends of the inner connecting plate (604) are fixed with sealing side push posts (609). The outer lower part of each group of sealing side push posts (609) is provided with a clamping hole (702). The outer side of the centrifuge tube (305) is arranged and fixed with a conical slide seat (703). The sliding sleeve (704) is slidably connected with the outer side of the centrifuge tube (305) and the outer side of the conical slide seat (703). The upper end of the main body of each group of side arms (310) is slidably connected with a passive clamping post (707) that bounces inward.

2. The device for preparing a nanosphere solution of a traditional Chinese medicine preparation according to claim 1, characterized in that: The main housing assembly (1) comprises a base (101), a main housing (102) and a main control screen (104); the top end of the base (101) is fixedly connected to the bottom end of the main housing (102); and the main control screen (104) is mounted and fixed on the lower end of the main surface of the main housing (102).

3. The device for preparing a nanosphere solution of a traditional Chinese medicine preparation according to claim 2, characterized in that: The liquid outlet component (2) further comprises a side seat (201), an inner seat (207) and a self-closing spring sheet (211); the side seat (201) is fixed to the lower end of the outer side surface of the main shell (102); the inner end bottom surface of the liquid outlet guide groove (202) is fixedly connected to the top of the base (101); the outer end extends from the main body of the main shell (102) into the side seat (201); the upper ends of both side surfaces of the side cover (203) are fixedly connected to side rotary arms (204); the side main body of the main shell (102) is symmetrically provided with side rotary holes (205); each group of side rotary holes (205) is fixedly connected to a soft sleeve (206); the side rotary arms (204) are fixedly connected to the side cover (203); 04) is connected to the soft sleeve (206), the inner seats (207) are fixedly connected in pairs to the inner cavity side of the main shell (102), the side of each set of side rotating arms (204) is laterally fixed with a side rotating shaft (208), the side rotating shaft (208) on the same side is rotationally connected to the inner seat (207), the passive protrusion (209) is fixedly connected to the inner end of the side rotating arm (204), and the side of each set of side rotating arms (204) is also fixedly connected to a spring clip holder (210), one end of the self-closing spring clip (211) is fixedly connected to the inner cavity side of the main shell (102), and the other end is fixedly connected to the spring clip holder (210).

4. A preparation device for a nanosphere solution of a traditional Chinese medicine preparation according to claim 2 or 3, characterized in that: The flip-type centrifugal assembly (3) further comprises a flip frame (303), a centrifugal gear (307), a fixed rod (314) and a servo electric cylinder (317). The top of the base (101) is fixedly connected to a stand (301), the top of the stand (301) is rotatably connected to a flip shaft (302), the bottom end of the flip frame (303) is fixedly connected to the middle of the flip shaft (302), the bottom end of the side arm (310) is fixedly connected to the outer end of the flip shaft (302), a pair of centrifugal seats (304) are fixedly installed in the top body of the flip frame (303), a centrifugal shaft (306) is fixedly installed at the outer bottom end of each group of centrifugal tubes (305), the centrifugal shaft (306) on the same side is rotatably connected to the centrifugal seat (304), the centrifugal gear (307) is plugged and fixed to the bottom end of the centrifugal shaft (306), a centrifugal motor (308) is fixedly installed inside the flip frame (303), and the centrifugal motor (308) is fixedly installed inside the flip frame (303). A centrifugal drive gear (309) is inserted and fixed in the rotating shaft of the machine (308), the centrifugal gear (307) meshes with the centrifugal drive gear (309), the bottom end of each set of side arms (310) is also fixedly connected to a flip pinion (311), flip drive shafts (312) are fixedly installed on both outer side surfaces of the stand (301), a flip drive large gear (313) is rotatably connected in each set of flip drive shafts (312), the flip pinions (311) on the same side mesh with the flip drive large gear (313), a fixed rod (314) is fixedly connected to the outer side surface of the flip drive large gear (313), a top end of the base (101) is fixed with electric cylinder fixed rotating seats (315) in pairs, the other end of each set of fixed rods (314) is fixed with an electric cylinder movable rotating seat (316), the main body of the servo electric cylinder (317) is rotatably connected to the electric cylinder fixed rotating seat (315), and the telescopic rod is rotatably connected to the electric cylinder movable rotating seat (316).

5. A device for preparing a nanosphere solution of a traditional Chinese medicine preparation according to claim 1, 2 or 3, characterized in that: The special-shaped guide surface (4) comprises an S-shaped guide surface (401) and a concave guide surface (402). The special-shaped guide surface (4) consists of the concave guide surface (402) and the S-shaped guide surfaces (401) symmetrically distributed on both sides.

6. A device for preparing a nanosphere solution of a traditional Chinese medicine preparation according to claim 2 or 3, characterized in that: The centrifugal sealing assembly (6) further comprises a slide seat (601) and an outer connecting plate (603). The slide seat (601) is fixedly mounted on the top of the main body of the main housing (102). The top of the inner connecting plate (604) is fixedly connected to a pair of slide posts (602). The outer connecting plate (603) is fixedly connected to the top of the slide posts (602). The slide posts (602) are slidably connected to the slide seat (601). A sealing top spring (605) is sleeved and mounted in each group of slide posts (602). One end of (605) is fixed to the inner connecting plate (604), and the other end is fixed to the inner top of the main shell (102). Passive rotating seats (606) are installed and fixed in pairs in the main body of the inner connecting plate (604). The top of the main body of the conical plug column (607) is rotatably connected to the passive rotating seat (606). A sealing sleeve (608) is fixedly sleeved on the outside of the main body of each group of conical plug columns (607), and a venting microhole (610) is opened in the middle of the main body of the conical plug column (607).

7. A device for preparing a nanosphere solution of a traditional Chinese medicine preparation according to claim 1, 2 or 3, characterized in that: The auxiliary clamping member (7) further comprises a clamping seat (701), a side sliding seat (706), a push spring (711) and a side sliding groove (713); the clamping seat (701) is fixedly connected to the outer end of the sealing side push column (609); the clamping hole (702) is provided at the bottom end of the clamping seat (701); a middle sliding hole (714) is provided in the middle of the sliding sleeve (704); the side sliding grooves (713) are symmetrically provided in the main body of the sliding sleeve (704); each group of side sliding grooves (713) is laterally slidably connected with an elastic alignment sliding seat (705); the outer side surface of the elastic alignment sliding seat (705) and the inner side surface of the side sliding groove (713) are provided with push spring clamping holes (710); the two ends of the push spring (711) are respectively fixedly connected to different push spring clamping holes (710); the inner side surface of the elastic alignment sliding seat (705) on the same side is connected to the conical The outer side of the slide seat (703) is slidably connected, and the middle slide hole (714) is slidably connected to the outer side of the centrifuge tube (305). Both ends of the conical slide seat (703) are fixedly connected with end sleeves (712), and the end sleeves (712) are sleeved and fixed with the outer side of the centrifuge tube (305). The upper end of the main body of each group of side arms (310) is provided with a compression spring placement hole (715). The side slide seat (706) is fixedly installed on the outer side of the upper end of the main body of the side arm (310). The passive clamping column (707) is slidably connected to the inner hole of the side slide seat (706). The inner end outer surface of the passive clamping column (707) is sleeved and fixed with a compression spring clamping sleeve (708). A compression spring (709) is sleeved and installed in each group of passive clamping columns (707). One end of the compression spring (709) is clamped with the compression spring clamping sleeve (708), and the other end is clamped with the inner bottom of the compression spring placement hole (715).

8. The device for preparing nanosphere solution of traditional Chinese medicine preparation according to claim 4, characterized in that: A liquid adding component (5) is also installed at the top of the main shell (102). The liquid adding component (5) comprises a liquid adding sliding sleeve (501) and a liquid adding inner connecting plate (505). The liquid adding sliding sleeves (501) are installed and fixed in pairs at the top of the main shell (102). A liquid adding tube (502) is slidably inserted in each set of liquid adding sliding sleeves (501). The liquid adding inner connecting plate (505) is fixedly connected between the lower outer surfaces of the liquid adding tubes (502). A liquid adding bucket (503) is fixedly connected to the top of each set of liquid adding tubes (502). A liquid adding top spring (506) is sleeved and installed in each set of liquid adding tubes (502). One end of the liquid adding top spring (506) is fixedly secured to the top of the liquid adding inner connecting plate (505), and the other end is fixedly secured to the inner top surface of the main shell (102). Both outer ends of the liquid adding inner connecting plate (505) are also fixedly connected to liquid adding side thrust columns (507).

9. A method for using the device for preparing nanosphere solution of a traditional Chinese medicine preparation according to claim 8, characterized in that: The following steps are involved: S1. An operator controls the movement of the telescopic rod of the servo electric cylinder (317) through the main control panel (104). The telescopic rod of the servo electric cylinder (317) can drive the rotation of the side arm (310) and the centrifuge tube (305) through the transmission mechanism. The centrifuge tube (305) can be rotated to a position where it is connected to the bottom opening of the liquid adding tube (502) by using the special-shaped guide surface (4). PLGA solutions of different ratios and specifications, a certain Chinese medicinal material solution, and distilled water can be quantitatively added into the centrifuge tube (305) through the liquid adding bucket (503) and the liquid adding tube (502); S2. After the solution is added to the centrifuge tube (305), the operator controls the movement of the telescopic rod of the servo electric cylinder (317) through the main control panel (104) again, so that the side arm (310) and the centrifuge tube (305) rotate and move in the direction of the centrifuge sealing assembly (6) until the centrifuge tube (305) rotates to a vertical state. With the use of the special-shaped guide surface (4), the conical plug post (607) in a freely rotating state is inserted into the top opening of the centrifuge tube (305), and the position of the plug hole (702) is horizontally opposite to the passive plug post (707); S3. The operator controls the rotation drive mechanism connected to the centrifuge tube (305) through the main control panel (104), and the centrifuge tube (305) rotates at a high speed. When the centrifuge tube (305) is vertical and rotates at a high speed, the sliding sleeve (704) can move from bottom to top along the conical slide seat (703), pushing the elastic inward passive clamping column (707) to move outward and insert it into the clamping hole (702), so that the solution in the centrifuge tube (305) and distilled water can be mixed stably and safely. A vent hole is opened in the middle of the conical plug column (607) to discharge dichloromethane; S4. After the preparation is completed, the solution is discharged. The main control panel (104) controls the rotation drive mechanism connected to the centrifuge tube (305). After the centrifugal rotation of the centrifuge tube (305) is completed, the rotation stops. The passive clamping column (707) returns to the inner side and is disconnected from the clamping hole (702). The operator controls the movement of the telescopic rod of the servo electric cylinder (317) through the main control panel (104), so that the servo electric cylinder (317) drives the rotation of the side arm (310) and the centrifuge tube (305) through the transmission mechanism, and cooperates with the The use of the shaped guide surface (4) allows the centrifuge tube (305) to rotate in the direction of the liquid outlet guide groove (202), and the side cover (203) in a naturally elastic closed state is opened through the sliding tangential cooperation formed between the outer surface of the shaped guide surface (4) and the passive protrusion (209), until the outer surface of the centrifuge tube (305) contacts the inner groove surface of the liquid outlet guide groove (202), and the two different traditional Chinese medicine preparation nanosphere solutions that have been centrifugally stirred in the centrifuge tube (305) are discharged from the liquid outlet guide groove (202) to be used in subsequent processes.

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